Relationships between dose to the gastro-intestinal tract and patient-reported symptom domains after radiotherapy for localized prostate cancer.
CONCLUSION: We have demonstrated that Defecation urgency, Fecal leakage, Mucous, and Pain following primary EBRT for localized prostate cancer primarily are predicted by intermediate rectal doses, low AS doses, high AS doses, or a combination of low AS and intermediate rectal doses, respectively. This suggests that there is a domain-specific dose-response for the GI tract. To reduce risk of GI morbidity, dose distributions of both the AS region and the rectum should, therefore, be considered when prescribing prostate cancer RT. PMID: 26340136 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - September 4, 2015 Category: Cancer & Oncology Authors: Thor M, Olsson CE, Oh JH, Petersen SE, Alsadius D, Bentzen L, Pettersson N, Muren LP, Waldenström AC, Høyer M, Steineck G, Deasy JO Tags: Acta Oncol Source Type: research

NTCP reduction for advanced head and neck cancer patients using proton therapy for complete or sequential boost treatment versus photon therapy.
CONCLUSIONS: The use of IMPT generally reduces the expected toxicity risk while maintaining good tumor coverage in the examined HNSCC patients. A mixed modality treatment using IMPT solely for a sequential boost reduces the risk by 10% only in rare cases. In contrast, pure IMPT treatment may be reasonable for about half of the examined patient cohort considering the toxicities xerostomia and dysphagia, if a feasible strategy for patient anatomy changes is implemented. PMID: 26340301 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - September 4, 2015 Category: Cancer & Oncology Authors: Jakobi A, Stützer K, Bandurska-Luque A, Löck S, Haase R, Wack LJ, Mönnich D, Thorwarth D, Perez D, Lühr A, Zips D, Krause M, Baumann M, Perrin R, Richter C Tags: Acta Oncol Source Type: research

Targeting tumour hypoxia to improve outcome of stereotactic radiotherapy.
In this study we investigated the role of hypoxia in a stereotactic radiation schedule by using a variety of hypoxic modifiers in a preclinical tumour model. MATERIAL AND METHODS: C3H mammary carcinomas were irradiated with 3 × 15 Gy during a one-week period, followed three days later by a clamped top-up dose to produce a dose response curve; the endpoint was tumour control. The hypoxic modifiers were nimorazole (200 mg/kg), nicotinamide (120 mg/kg) and carbogen (95% O2 + 5% CO2) breathing, OXi4503 (10 mg/kg), and hyperthermia (41.5°C; 1 h). RESULTS: The radiation dose controlling 50% of clamped tumours...
Source: Acta Oncologica - September 2, 2015 Category: Cancer & Oncology Authors: Wittenborn TR, Horsman MR Tags: Acta Oncol Source Type: research

Imaging in particle therapy: State of the art and future perspective.
PMID: 26329760 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - September 2, 2015 Category: Cancer & Oncology Authors: Seco J, Spadea MF Tags: Acta Oncol Source Type: research

Intra-fractional bladder motion and margins in adaptive radiotherapy for urinary bladder cancer.
CONCLUSION: In this phase II ART trial, 5 mm isotropic margin for intra-fractional motion was sufficient even though considerable intra-fractional motion was observed. In online re-optimised ART, population-based margin can be applied although patient-specific margins are preferable. PMID: 26313410 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - August 27, 2015 Category: Cancer & Oncology Authors: Grønborg C, Vestergaard A, Høyer M, Söhn M, Pedersen EM, Petersen JB, Agerbæk M, Muren LP Tags: Acta Oncol Source Type: research

EGFR mutation testing of lung cancer patients - Experiences from Vestfold Hospital Trust.
DISCUSSION: Especially for patients with advanced stages of NSCLC, EGFR mutation status is necessary for treatment stratification. Our results show that the guidelines were followed increasingly over time for patients diagnosed with NSCLC at the Vestfold Hospital Trust. The establishment of interdisciplinary meetings has improved the diagnostic routines. PMID: 26313507 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - August 27, 2015 Category: Cancer & Oncology Authors: Berg J, Fjellbirkeland L, Suhrke P, Jebsen P, Lund-Iversen M, Kleinberg L, Helgeland L, Brustugun OT, Helland Å Tags: Acta Oncol Source Type: research

Prognostic factors for the feasibility of chemotherapy and the Geriatric Prognostic Index (GPI) as risk profile for mortality before chemotherapy in the elderly.
Abstract BACKGROUND: Comprehensive geriatric assessment (CGA) is a multidimensional method to detect frailty in elderly patients. Time saving could be accomplished by identifying those individual items that classify elderly cancer patients at risk for feasibility of chemotherapy and for mortality. MATERIAL AND METHODS: Patients older than 70 years of age were assessed before the first chemotherapy administration. GA consisted of the Mini Nutritional Assessment (MNA), Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE), Groningen Frailty Indicator (GFI) and Mini Mental State Examination (MMSE)...
Source: Acta Oncologica - August 25, 2015 Category: Cancer & Oncology Authors: Aaldriks AA, Maartense E, Nortier HJ, van der Geest LG, le Cessie S, Tanis BC, Portielje JE, Ypma P, Giltay EJ Tags: Acta Oncol Source Type: research

Relative biological effectiveness of carbon ions for tumor control, acute skin damage and late radiation-induced fibrosis in a mouse model.
CONCLUSION: The observed RBE values were very similar for tumor response, acute skin damage and late RIF when irradiated with large doses of high- linear energy transfer (LET) carbon ions. This study adds information to the variation in biological effectiveness in different tumor and normal tissue models. PMID: 26271798 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - August 14, 2015 Category: Cancer & Oncology Authors: Sørensen BS, Horsman MR, Alsner J, Overgaard J, Durante M, Scholz M, Friedrich T, Bassler N Tags: Acta Oncol Source Type: research

Impact of radiation dose and standardized uptake value of (18)FDG PET on nodal control in locally advanced cervical cancer.
JC Abstract BACKGROUND: Despite local control now exceeding 90% with image-guided adaptive brachytherapy (IGABT), regional and distant metastases continue to curb survival in locally advanced cervical cancer. As regional lymph nodes often represent first site of metastatic spread, improved nodal control could improve survival. The aim of this study was to examine optimal volume and dose of external beam radiotherapy (EBRT) to maximize regional control including dose contribution from IGABT. MATERIAL AND METHODS: In total 139 patients from the EMBRACE study were analyzed. Individual nodal dose was determined ...
Source: Acta Oncologica - August 14, 2015 Category: Cancer & Oncology Authors: Ramlov A, Kroon PS, Jürgenliemk-Schulz IM, De Leeuw AA, Gormsen LC, Fokdal LU, Tanderup K, Lindegaard JC Tags: Acta Oncol Source Type: research

Prognostic factors for the feasibility of chemotherapy and the Geriatric Prognostic Index (GPI) as risk profile for mortality before chemotherapy in the elderly.
Abstract BACKGROUND: Comprehensive geriatric assessment (CGA) is a multidimensional method to detect frailty in elderly patients. Time saving could be accomplished by identifying those individual items that classify elderly cancer patients at risk for feasibility of chemotherapy and for mortality. MATERIAL AND METHODS: Patients older than 70 years of age were assessed before the first chemotherapy administration. GA consisted of the Mini Nutritional Assessment (MNA), Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE), Groningen Frailty Indicator (GFI) and Mini Mental State Examination (MMSE)...
Source: Acta Oncologica - August 14, 2015 Category: Cancer & Oncology Authors: Aaldriks AA, Maartense E, Nortier HJ, van der Geest LG, le Cessie S, Tanis BC, Portielje JE, Ypma P, Giltay EJ Tags: Acta Oncol Source Type: research

External validation of a prognostic CT-based radiomic signature in oropharyngeal squamous cell carcinoma.
Abstract Oropharyngeal squamous cell carcinoma (OPSCC) is one of the fastest growing disease sites of head and neck cancers. A recently described radiomic signature, based exclusively on pre-treatment computed tomography (CT) imaging of the primary tumor volume, was found to be prognostic in independent cohorts of lung and head and neck cancer patients treated in the Netherlands. Here, we further validate this signature in a large and independent North American cohort of OPSCC patients, also considering CT artifacts. METHODS: A total of 542 OPSCC patients were included for which we determined the prognostic i...
Source: Acta Oncologica - August 12, 2015 Category: Cancer & Oncology Authors: Leijenaar RT, Carvalho S, Hoebers FJ, Aerts HJ, van Elmpt WJ, Huang SH, Chan B, Waldron JN, O'sullivan B, Lambin P Tags: Acta Oncol Source Type: research

Validation of a gene expression profile predictive of the risk of radiation-induced fibrosis in women treated with breast conserving therapy.
PMID: 26268305 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - August 12, 2015 Category: Cancer & Oncology Authors: Lyngholm CD, Overgaard J, Christiansen PM, Alsner J Tags: Acta Oncol Source Type: research

Immunohistochemical biomarkers and FDG uptake on PET/CT in head and neck squamous cell carcinoma.
Abstract BACKGROUND: There is an exciting complementarity between the spatial resolution provided by molecular imaging of a single, often unspecific, biomarker on one hand and the more detailed biological profile achievable from a diagnostic biopsy using a panel of immunohistochemical (IHC) markers on the other. A number of previous studies have shown a relationship between glucose transport protein expression and 18F-Fludeoxyglucose (FDG) PET uptake. Here, FDG uptake is analyzed in relation to expression of a selected panel of IHC cancer biomarkers in head and neck squamous cell carcinomas (HNSCC). MATERIAL ...
Source: Acta Oncologica - August 9, 2015 Category: Cancer & Oncology Authors: Rasmussen GB, Vogelius IR, Rasmussen JH, Schumaker L, Ioffe O, Cullen K, Fischer BM, Therkildsen MH, Specht L, Bentzen SM Tags: Acta Oncol Source Type: research

Development of a disease-specific health-related quality of life (HRQoL) questionnaire intended to be used in conjunction with the general European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire (QLQ) in renal cell carcinoma patients.
CONCLUSIONS: The suggested disease-specific EORTC-QLQ-style RCC10 version adds important information about the HRQoL of RCC patients, providing additional apparent value to the general questionnaire and personality variables, as well as being psychometrically satisfactory. The questionnaire has a potential as a "stand alone" HRQoL questionnaire among RCC patients. PMID: 26251300 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - August 7, 2015 Category: Cancer & Oncology Authors: Beisland E, Aarstad HJ, Aarstad AK, Bakke A, Bostad L, Beisland C Tags: Acta Oncol Source Type: research

Performance evaluation of head and neck contour adaptation with cone beam CT using two commercial software systems.
PMID: 26252347 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - August 7, 2015 Category: Cancer & Oncology Authors: Bendall LS, Najim M, Stensmyr R, Flower E, Yau S, Thwaites DI, Sykes JR Tags: Acta Oncol Source Type: research

Intra-fractional bladder motion and margins in adaptive radiotherapy for urinary bladder cancer.
CONCLUSION: In this phase II ART trial, 5 mm isotropic margin for intra-fractional motion was sufficient even though considerable intra-fractional motion was observed. In online re-optimised ART, population-based margin can be applied although patient-specific margins are preferable. PMID: 26252348 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - August 7, 2015 Category: Cancer & Oncology Authors: Grønborg C, Vestergaard A, Høyer M, Söhn M, Pedersen EM, Petersen JB, Agerbæk M, Muren LP Tags: Acta Oncol Source Type: research

Development of a method for functional aspect identification in parotid using dynamic contrast-enhanced magnetic resonance imaging and concurrent stimulation.
PMID: 26252349 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - August 7, 2015 Category: Cancer & Oncology Authors: Clark HD, Moiseenko VV, Rackley TP, Thomas SD, Wu JS, Reinsberg SA Tags: Acta Oncol Source Type: research

EGFR imaging in human head and neck cancer xenografts.
Abstract Molecular imaging of specific biomarkers can have prognostic, predictive or monitoring value in head and neck squamous cell carcinoma (HNSCC). The epidermal growth factor receptor (EGFR) is involved in various radiation resistance mechanisms as it steers the pathways related to DNA damage repair, proliferation, hypoxia and apoptosis. Radiolabeled labeled F(ab')2 fragments of the EGFR antibody cetuximab can be applied for non-invasive imaging of this receptor. Preclinical studies have shown that radioresistant tumors had a higher tracer uptake after irradiation, probably due to upregulation of membranous E...
Source: Acta Oncologica - August 6, 2015 Category: Cancer & Oncology Authors: van Dijk LK, Boerman OC, Kaanders JH, Bussink J Tags: Acta Oncol Source Type: research

External validation of a normal tissue complication probability (NTCP) model for radiation-induced hypothyroidism in an independent cohort.
CONCLUSION: Dmean and Vthyroid were significant predictors of RIHT in both cohorts. The original NTCP model demonstrated external validity owing to high Pearson's correlation coefficients between estimated and observed incidence rates of RIHT in the original as well as in the validation cohort. This model may facilitate clinically relevant estimations of RIHT after RT to the neck. PMID: 26248025 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - August 6, 2015 Category: Cancer & Oncology Authors: Rønjom MF, Brink C, Bentzen SM, Hegedüs L, Overgaard J, Petersen JB, Primdahl H, Johansen J Tags: Acta Oncol Source Type: research

Levonorgestrel-releasing intrauterine system and the risk of breast cancer: A nationwide cohort study.
CONCLUSIONS: The results imply that intrauterine administration of levonorgestrel is not only related to an excess risk of lobular breast cancer but also, in contrary to previous assumptions, to an excess risk of ductal breast cancer. PMID: 26243443 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - August 4, 2015 Category: Cancer & Oncology Authors: Soini T, Hurskainen R, Grénman S, Mäenpää J, Paavonen J, Joensuu H, Pukkala E Tags: Acta Oncol Source Type: research

The effect of region of interest strategies on apparent diffusion coefficient assessment in patients treated with palliative radiation therapy to brain metastases.
CONCLUSION: The ROI strategies have an effect on the relative ADC change, which may be important for the assessment of individual patient's response to RT and the interpretation of the current literature. PMID: 26236963 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - August 3, 2015 Category: Cancer & Oncology Authors: Mahmood F, Johannesen HH, Geertsen P, Opheim GF, Hansen RH Tags: Acta Oncol Source Type: research

Deciding about (neo-)adjuvant rectal and breast cancer treatment: Missed opportunities for shared decision making.
CONCLUSION: This study suggests that oncologists rarely express that a treatment decision needs to be made in consultations concerning preference-sensitive treatment decisions. Therefore, patients might not realize that foregoing (neo-)adjuvant treatment is a viable choice. Oncologists miss a crucial opportunity to facilitate SDM. PMID: 26237738 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - August 3, 2015 Category: Cancer & Oncology Authors: Kunneman M, Engelhardt EG, Ten Hove FL, Marijnen CA, Portielje JE, Smets EM, de Haes HJ, Stiggelbout AM, Pieterse AH Tags: Acta Oncol Source Type: research

Risk of radiation-induced secondary rectal and bladder cancer following radiotherapy of prostate cancer.
CONCLUSIONS: The SC risk estimations for the bladder and rectum revealed no clear relative relationship between the contemporary techniques and CRT, with divergent results depending on choice of model. However, the SC risks for these organs when using IMPT were lower or comparable to VMAT. SC risks could be assessed when considering referral of prostate cancer patients to proton therapy, taking also general patient characteristics, such as age, into account. PMID: 26230629 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - July 31, 2015 Category: Cancer & Oncology Authors: Stokkevåg CH, Engeseth GM, Hysing LB, Ytre-Hauge KS, Ekanger C, Muren LP Tags: Acta Oncol Source Type: research

Diagnosis and treatment of bronchopulmonary neuroendocrine tumours: State of the art.
Ladekarl M Abstract Bronchopulmonary neuroendocrine tumours (BP-NET) are a heterogeneous population of neoplasms with different pathology, clinical behaviour and prognosis compared to the more common lung cancers. The management of BP-NET patients is largely based on studies with a low level of evidence and extrapolation of data obtained from more common types of neuroendocrine tumours. This review reflects our view of the current state of the art of diagnosis and treatment of patients with BP-NET. PMID: 26223571 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - July 30, 2015 Category: Cancer & Oncology Authors: Tabaksblat EM, Langer SW, Knigge U, Grønbæk H, Mortensen J, Petersen RH, Federspiel BH, Ladekarl M Tags: Acta Oncol Source Type: research

Changes in the radiological depth correlate with dosimetric deterioration in particle therapy for stage I NSCLC patients under high frequency jet ventilation.
CONCLUSION: Software tools for fast online analysis of WEPL changes might help supporting clinical decision making of image guidance. Raster scan and treatment planning settings can help to compensate for anatomical deviations. PMID: 26228661 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - July 30, 2015 Category: Cancer & Oncology Authors: Santiago A, Fritz P, Mühlnickel W, Engenhart-Cabillic R, Wittig A Tags: Acta Oncol Source Type: research

Dosimetric evaluation of anatomical changes during treatment to identify criteria for adaptive radiotherapy in oesophageal cancer patients.
CONCLUSION: Target coverage throughout the course of chemoRT treatment is compromised in some patients due to interfractional anatomical changes. Dose to the heart may increase as well. PMID: 26223492 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - July 29, 2015 Category: Cancer & Oncology Authors: Nyeng TB, Nordsmark M, Hoffmann L Tags: Acta Oncol Source Type: research

Volumetric and dosimetric changes to salivary glands during radiotherapy for head and neck cancer.
PMID: 26219957 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - July 29, 2015 Category: Cancer & Oncology Authors: Najim M, Perera L, Bendall L, Sykes JR, Gebski V, Cross S, Veness M Tags: Acta Oncol Source Type: research

Weekly kilovoltage cone-beam computed tomography for detection of dose discrepancies during (chemo)radiotherapy for head and neck cancer.
CONCLUSION: Weekly dose calculations do not seem to improve dose delivery for patients with tumors of the oral cavity, oropharynx, larynx and hypopharynx. In patients with nasopharyngeal carcinoma, however, mid-treatment imaging may facilitate DGRT. PMID: 26219958 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - July 29, 2015 Category: Cancer & Oncology Authors: Hermans BC, Persoon LC, Podesta M, Hoebers FJ, Verhaegen F, Troost EG Tags: Acta Oncol Source Type: research

A simulation study on proton computed tomography (CT) stopping power accuracy using dual energy CT scans as benchmark.
CONCLUSION: Better stopping power estimates could significantly reduce the range errors in proton therapy, but requires a large improvement in current methods which may be achievable with proton CT. PMID: 26219959 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - July 29, 2015 Category: Cancer & Oncology Authors: Hansen DC, Seco J, Sørensen TS, Petersen JB, Wildberger JE, Verhaegen F, Landry G Tags: Acta Oncol Source Type: research

Diffusion-weighted magnetic resonance imaging during radiotherapy of locally advanced cervical cancer - treatment response assessment using different segmentation methods.
This study evaluates: 1) different segmentation methods; and 2) how they affect assessment of tumor ADC value during RT. MATERIAL AND METHODS: Eleven patients with locally advanced cervical cancer underwent MRI three times during their RT: prior to start of RT (PRERT), two weeks into external beam RT (WK2RT) and one week prior to brachytherapy (PREBT). Volumes on DW-MRI were segmented using three semi-automatic segmentation methods: "cluster analysis", "relative signal intensity (SD4)" and "region growing". Segmented volumes were compared to the gross tumor volume (GTV) identified on T2-w...
Source: Acta Oncologica - July 28, 2015 Category: Cancer & Oncology Authors: Haack S, Tanderup K, Kallehauge JF, Mohamed SM, Lindegaard JC, Pedersen EM, Jespersen SN Tags: Acta Oncol Source Type: research

Incidence of cancer among grand multiparous women in Finland with special focus on non-gynaecological cancers: A population-based cohort study.
CONCLUSION: The study demonstrated that grand multiparous women have a similar overall risk of non-gynaecological cancers as other women, despite significant differences in some specific forms of cancer. PMID: 26217985 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - July 28, 2015 Category: Cancer & Oncology Authors: Högnäs E, Kauppila A, Hinkula M, Tapanainen JS, Pukkala E Tags: Acta Oncol Source Type: research

Optimal fractionation in radiotherapy for non-small cell lung cancer - a modelling approach.
CONCLUSIONS: For well oxygenated tumours, heterogeneous fractionation schedules could increase local control rates substantially compared to CFRT. For hypoxic tumours, SBRT-like hypofractionated schedules might be optimal despite the increased risk of intra-fraction repair due to a synergistic effect with inter-fraction reoxygenation. PMID: 26217986 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - July 28, 2015 Category: Cancer & Oncology Authors: Lindblom E, Dasu A, Toma-Dasu I Tags: Acta Oncol Source Type: research

Variability of dynamic 18F-FDG-PET data in breast cancer xenografts.
CONCLUSIONS: SUVmean and SUVmedian show less variability than SUVmax. The pharmacokinetic tumour metrics again display much greater variability than the SUV-based metrics. However, it is generally not known which of these metrics that best represents cancer aggressiveness and their use may still depend on the research questions addressed. PMID: 26217987 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - July 28, 2015 Category: Cancer & Oncology Authors: Pitman KE, Rusten E, Kristian A, Malinen E Tags: Acta Oncol Source Type: research

Cardiac monitoring during adjuvant trastuzumab therapy: Guideline adherence in clinical practice.
Abstract BACKGROUND: Cardiotoxicity is an important adverse effect of adjuvant breast cancer treatment with trastuzumab and three monthly left ventricular ejection fraction (LVEF) monitoring is considered mandatory. The purpose of this study was to gain insight into LVEF monitoring during adjuvant trastuzumab treatment in clinical practice. MATERIAL AND METHODS: In a multicenter retrospective study encompassing 328 patients, of which 171 patients were actually treated with trastuzumab, we analyzed the frequency and mode of LVEF monitoring and compared it with LVEF monitoring guidelines. RESULTS: The resu...
Source: Acta Oncologica - July 28, 2015 Category: Cancer & Oncology Authors: Visser A, van de Ven EM, Ruczynski LI, Blaisse RJ, van Halteren HK, Aben K, van Laarhoven HW Tags: Acta Oncol Source Type: research

The need for radiotherapy in Europe in 2020: Not only data but also a cancer plan.
DISCUSSION: It is argued that these should be considered the optimal proportions of cancer patients, but a more realistic policy target could be set at 80% or higher of the optimal proportion. This realistic target also takes into account the inherent uncertainties in the assessment of evidence, and other factors that influence clinical decision-making in cases of multi-morbidity or patient preferences. Other factors are associated with problems that should be dealt with in the framework of a cancer plan, such as accessibility, preference bias in physician evaluation of the indication or shortage of resources, and the impa...
Source: Acta Oncologica - July 27, 2015 Category: Cancer & Oncology Authors: Borras JM, Lievens Y, Grau C Tags: Acta Oncol Source Type: research

Dose painting by numbers in a standard treatment planning system using inverted dose prescription maps.
Malinen E Abstract BACKGROUND: Dose painting by numbers (DPBN) is a method to deliver an inhomogeneous tumor dose voxel-by-voxel with a prescription based on biological medical images. However, planning of DPBN is not supported by commercial treatment planning systems (TPS) today. Here, a straightforward method for DPBN with a standard TPS is presented. MATERIAL AND METHODS: DPBN tumor dose prescription maps were generated from (18)F-FDG-PET images applying a linear relationship between image voxel value and dose. An inverted DPBN prescription map was created and imported into a standard TPS where it was def...
Source: Acta Oncologica - July 27, 2015 Category: Cancer & Oncology Authors: Arnesen MR, Knudtsen IS, Rekstad BL, Eilertsen K, Dale E, Bruheim K, Helland Å, Løndalen AM, Hellebust TP, Malinen E Tags: Acta Oncol Source Type: research

A learning programme qualifying radiation therapists to manage daily online adaptive radiotherapy.
rau C PMID: 26213312 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - July 27, 2015 Category: Cancer & Oncology Authors: Boejen A, Vestergaard A, Hoffmann L, Ellegaard MB, Rasmussen AM, Møller D, Muren LP, Grau C Tags: Acta Oncol Source Type: research

Imaging of tumour hypoxia and metabolism in patients with head and neck squamous cell carcinoma.
We report the mean± standard deviation. RESULTS: PET/CT scans including 20 GTVprim and 12 GTVlnwere analysed. There was a significant correlation between several [(18)F]FDG and [(18)F]HX4 parameters, the most pronounced being the correlation between [(18)F]FDG HV and [(18)F]HX4 HV (R = 0.93, p
Source: Acta Oncologica - July 27, 2015 Category: Cancer & Oncology Authors: Zegers CM, van Elmpt W, Hoebers FJ, Troost EG, Öllers MC, Mottaghy FM, Lambin P Tags: Acta Oncol Source Type: research

Impact of early disease progression and surgical complications on adjuvant chemotherapy completion rates and survival in patients undergoing the surgery first approach for resectable pancreatic ductal adenocarcinoma - A population-based cohort study.
ug IP Abstract BACKGROUND: Multimodality treatment (MMT) improves survival for patients with pancreatic ductal adenocarcinoma (PDAC). The surgery-first (SF) strategy is the most universally accepted approach. MATERIAL AND METHODS: Population-based retrospective cohort study of all cases of resectable PDAC from 2006 to 2012. Patients were planned for adjuvant chemotherapy (AC) with the Nordic 5-fluorouracil/leucovorin regimen. Reasons for and rates of failure to complete AC, postoperative major complications (PMC), and overall survival (OS) were analysed. RESULTS: Of 203 patients, 85 (41.9%) completed AC,...
Source: Acta Oncologica - July 25, 2015 Category: Cancer & Oncology Authors: Labori KJ, Katz MH, Tzeng CW, Bjørnbeth BA, Cvancarova M, Edwin B, Kure EH, Eide TJ, Dueland S, Buanes T, Gladhaug IP Tags: Acta Oncol Source Type: research

Clinical outcome of image-guided adaptive radiotherapy in the treatment of lung cancer patients.
CONCLUSION: In the first small cohort of patients investigated, implementation of soft-tissue tumour match and adaptive strategies for locally advanced lung cancer patients increased the loco-regional control rate without increasing treatment-related toxicity. PMID: 26206515 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - July 24, 2015 Category: Cancer & Oncology Authors: Tvilum M, Khalil AA, Møller DS, Hoffmann L, Knap MM Tags: Acta Oncol Source Type: research

Quality assurance of radiation therapy for head and neck cancer patients treated in DAHANCA 10 randomized trial.
rau C PMID: 26206516 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - July 24, 2015 Category: Cancer & Oncology Authors: Hansen CR, Johansen J, Kristensen CA, Smulders B, Andersen LJ, Samsøe E, Andersen E, Petersen JB, Overgaard J, Grau C Tags: Acta Oncol Source Type: research

Comparison of onboard low-field magnetic resonance imaging versus onboard computed tomography for anatomy visualization in radiotherapy.
CONCLUSION: Low-field MR provides better anatomic visualization of many radiotherapy targets and most OARs as compared to OB-CT. Further studies with OB-MRI should be pursued. PMID: 26206517 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - July 24, 2015 Category: Cancer & Oncology Authors: Noel CE, Parikh PJ, Spencer CR, Green OL, Hu Y, Mutic S, Olsen JR Tags: Acta Oncol Source Type: research

Adaptation requirements due to anatomical changes in free-breathing and deep-inspiration breath-hold for standard and dose-escalated radiotherapy of lung cancer patients.
CONCLUSION: Phantom simulations provided potential adaptation action levels for PE and TS. For the more complex patient geometry, individual assessment of the dosimetric impact is recommended for both ST and DE plans in DIBH as well as in FB. However, DIBH was found to be superior over FB for DE plans, regarding robustness of GTV-T to TS. PMID: 26206518 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - July 24, 2015 Category: Cancer & Oncology Authors: Sibolt P, Ottosson W, Sjöström D, Larsen C, Behrens CF Tags: Acta Oncol Source Type: research

Evaluation of factors associated with loco-regional failure and survival in limited disease small cell lung cancer patients treated with chemoradiotherapy.
CONCLUSION: N3-stage was an independent prognostic factor for LRF. Receiving a pretreatment PET scan and receiving PCI were prognostic factors for improved OS. Reduction in LRF may be achieved with dose-escalation in patients with N3-stage. This can be evaluated in prospective dose-escalation trials. PMID: 26203924 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - July 23, 2015 Category: Cancer & Oncology Authors: Winther-Larsen A, Hoffmann L, Moeller DS, Khalil AA, Knap MM Tags: Acta Oncol Source Type: research

Early volume variation of positive lymph nodes assessed by in-room MVCT images predicts risk of loco-regional relapses in head and neck cancer patients treated with IMRT.
CONCLUSION: A limited shrinkage of PNs during treatment is associated with poorer outcome in terms of T/N relapses. The early variation of PNs observed on in-room images may provide useful information about the individual response with potential application in guiding an early adaptation of the treatment. PMID: 26203925 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - July 23, 2015 Category: Cancer & Oncology Authors: Belli ML, Fiorino C, Zerbetto F, Raso R, Broggi S, Chiara A, Cattaneo GM, Di Muzio N, Dell'oca I, Calandrino R Tags: Acta Oncol Source Type: research

Early changes in perfusion of glioblastoma during radio- and chemotherapy evaluated by T1-dynamic contrast enhanced magnetic resonance imaging.
The objective of this study was to measure changes in the vascular physiology of tumor using T1-dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) in patients with glioblastoma during early stages of radio- and chemotherapy (Tx) and explore possible correlations with treatment outcomes. MATERIAL AND METHODS: An exploratory prospective study was planned. Patients underwent DCE-MRI at baseline, after approximately one and six weeks of Tx and three and six months post-Tx. DCE-MRI at three Tesla generated maps of blood flow (BF), blood volume (BV), permeability (Ki) and volume of distribution (Vd) using a comb...
Source: Acta Oncologica - July 23, 2015 Category: Cancer & Oncology Authors: Møller S, Lundemann M, Law I, Poulsen HS, Larsson HB, Engelholm SA Tags: Acta Oncol Source Type: research

Prostate displacement during transabdominal ultrasound image-guided radiotherapy assessed by real-time four-dimensional transperineal monitoring.
CONCLUSION: The novel 4D TPUS system was capable of tracking and recording the prostate positional displacements. The study demonstrated that the prostate induced displacements due to applied TAUS IGRT are small, and in most cases clinically irrelevant to prostate radiotherapy. PMID: 26203927 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - July 23, 2015 Category: Cancer & Oncology Authors: Baker M, Behrens CF Tags: Acta Oncol Source Type: research

Comparison of [18F]-FMISO, [18F]-FAZA and [18F]-HX4 for PET imaging of hypoxia - a simulation study.
CONCLUSIONS: In line with recent experimental and clinical data, the results suggest that HX4 is a promising new tracer that provides high image contrast four hours p.i., though inter-patient variance can be very high. Nevertheless, the widely used tracer FMISO provides a robust and reproducible signal four hours p.i., but with a lower contrast. The simulations revealed tracer clearance to be the key factor in determining image contrast. PMID: 26203928 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - July 23, 2015 Category: Cancer & Oncology Authors: Wack LJ, Mönnich D, van Elmpt W, Zegers CM, Troost EG, Zips D, Thorwarth D Tags: Acta Oncol Source Type: research

Toward a more patient-specific model of post-radiotherapy saliva secretion for head and neck cancer patients.
CONCLUSIONS: The salivary flow model was validated for 64 patients. The results imply, that one explanation for the discrepancies between the predicted and the measured salivary flow rate values and the common variations found in ΔrEF for the parotid glands may be differences in patients' individual response to radiation. However, quantitative extraction of individual radiosensitivity would require further studies in order to take it into account in predictive models. PMID: 26203929 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - July 23, 2015 Category: Cancer & Oncology Authors: Tuomikoski L, Kapanen M, Collan J, Keyriläinen J, Saarilahti K, Loimu V, Seppälä T, Tenhunen M Tags: Acta Oncol Source Type: research

Loss of lung function after chemo-radiotherapy for NSCLC measured by perfusion SPECT/CT: Correlation with radiation dose and clinical morbidity.
CONCLUSION: Perfusion lung function changes in a dose-dependent manner after RT. The severity of radiation-induced lung symptoms is significantly correlated with SPECT perfusion changes. Perfusion reduction early after RT is associated with a high risk of later development of symptomatic RP. PMID: 26203930 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - July 23, 2015 Category: Cancer & Oncology Authors: Farr KP, Møller DS, Khalil AA, Kramer S, Morsing A, Grau C Tags: Acta Oncol Source Type: research