Male coping through a long-term cancer trajectory. Secondary outcomes from a RTC examining the effect of a multidisciplinary rehabilitation program (RePCa) among radiated men with prostate cancer.
CONCLUSION: Multidisciplinary rehabilitation in irradiated prostate cancer patients retained the adjustment style Fighting Spirit stable after six months of radiotherapy, and in the long term reduced Cognitive Avoidance. Thus, the rehabilitation program supported the patient's active coping style and played down the passive coping style. PMID: 28093012 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 17, 2017 Category: Cancer & Oncology Authors: Dieperink KB, Johansen C, Hansen S, Wagner L, K Andersen K, Minet LR, Hansen O Tags: Acta Oncol Source Type: research

Sustained employability and health-related quality of life in cancer survivors up to four years after diagnosis.
CONCLUSION: Cancer survivors 'continuously working' function better and have a better health and QoL than those who are not able to work. However, in occupationally active cancer survivors, one should monitor those with low self-perceived work ability, because they have an increased risk to discontinue their work. PMID: 28093023 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 17, 2017 Category: Cancer & Oncology Authors: Duijts SF, Kieffer JM, van Muijen P, van der Beek AJ Tags: Acta Oncol Source Type: research

Fear of cancer recurrence and unmet needs among breast cancer survivors in the first five years. A cross-sectional study.
CONCLUSIONS: Breast cancer survivors experience substantial unmet needs years after end of treatment, particularly among younger women and women having clinical FCR. Furthermore, FCR is frequent among women, particularly when closer in time to primary surgery. PMID: 28093034 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 17, 2017 Category: Cancer & Oncology Authors: Ellegaard MB, Grau C, Zachariae R, Bonde Jensen A Tags: Acta Oncol Source Type: research

Prolonged job strain and subsequent risk of cancer in women - a longitudinal study, based on the Danish Nurse Cohort.
CONCLUSION: We found no evidence of an increased risk of any cancer among women with prolonged job strain. Since a large proportion of cancer patients perceive psychological stress as a possible cause of their cancer disease, it is of importance to communicate these findings to the public. PMID: 28093051 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 17, 2017 Category: Cancer & Oncology Authors: Vesterlund GK, Høeg BL, Johansen C, Heitmann BL, E Bidstrup P Tags: Acta Oncol Source Type: research

Recruiting newly referred lung cancer patients to a patient navigator intervention (PACO): lessons learnt from a pilot study.
CONCLUSIONS: The pilot study met a number of internal and external obstacles to patients' recruitment. The study provides insight into the barriers to recruitment of socially disadvantaged cancer patients to clinical trials and will inform future trial designs. PMID: 28094601 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 17, 2017 Category: Cancer & Oncology Authors: Kjær TK, Mellemgaard A, Stensøe Oksen M, Andreassen Rix B, Karlsen R, Johansen C, Dalton SO Tags: Acta Oncol Source Type: research

Clinical and psychological moderators of the effect of mindfulness-based cognitive therapy on persistent pain in women treated for primary breast cancer - explorative analyses from a randomized controlled trial.
CONCLUSION: Attachment avoidance, and potentially radiotherapy, may be clinically relevant factors for identifying the patients who may benefit most from MBCT as a pain intervention. Due to the exploratory nature of the analyses, the results should be considered preliminary. PMID: 28094662 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 17, 2017 Category: Cancer & Oncology Authors: Johannsen M, O'Toole MS, O'Connor M, Jensen AB, Zachariae R Tags: Acta Oncol Source Type: research

Feasibility and acceptability of active book clubs in cancer survivors - an explorative investigation.
CONCLUSION: The 'Active Book Club' represents a novel psychosocial intervention potentially supporting physical activity adoption and mental health in cancer survivors. However, several issues related to feasibility and acceptability including choice of literature genre, format and supervision of book club meetings need to be considered before larger scale clinical trials are initiated. PMID: 28094664 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 17, 2017 Category: Cancer & Oncology Authors: Hammer NM, Egestad LK, Nielsen SG, Bjerre E, Johansen C, Egerod I, Pinto B, Midtgaard J Tags: Acta Oncol Source Type: research

FDG-PET reproducibility in tumor-bearing mice: comparing a traditional SUV approach with a tumor-to-brain tissue ratio approach.
CONCLUSIONS: Multimodality scanners allow tissue delineation and normalization of tumor FDG uptake relative to reference tissues. Normalization to brain, but not liver or kidney, improved scan reproducibility considerably and was superior to traditional SUV quantification in i.v. tracer-injected animals. Day-to-day variability in SUV's was lower in i.p. than in i.v. injected animals, and i.p. injections may therefore be a valuable alternative in prolonged rodent studies, where repeated vein injections are undesirable. PMID: 28094665 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 17, 2017 Category: Cancer & Oncology Authors: Busk M, Munk OL, Jakobsen S, Frøkiær J, Overgaard J, Horsman MR Tags: Acta Oncol Source Type: research

The impact of cancer survivorship care plans on patient and health care provider outcomes: a current perspective.
CONCLUSION: Currently, there is not enough evidence to warrant large-scale implementation of SCPs, or to abandon SCPs altogether. Emphasis on the SCP process and survivor engagement, supporting self-management may be an important way forward in SCP delivery. Whether this is beneficial and cost-effective on the long term and among different groups of cancer survivors needs further investigation. PMID: 28084140 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 13, 2017 Category: Cancer & Oncology Authors: van de Poll-Franse LV, Nicolaije KA, Ezendam NP Tags: Acta Oncol Source Type: research

Progressive strength training to prevent LYmphoedema in the first year after breast CAncer - the LYCA feasibility study.
CONCLUSION: Recruitment, testing, and exercise in LYCA was safe and feasible. At the 50-week follow-up, there was one case of lymphoedema. The LYCA program will be further tested in a full-scale RCT. PMID: 28084150 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 13, 2017 Category: Cancer & Oncology Authors: Ammitzbøll G, Lanng C, Kroman N, Zerahn B, Hyldegaard O, Kaae Andersen K, Johansen C, Dalton SO Tags: Acta Oncol Source Type: research

Radiotherapy-induced vaginal fibrosis in cervical cancer survivors.
k K Abstract BACKGROUND: Cervical cancer survivors treated with radiotherapy report vaginal inelasticity and decreased lubrication that may affect their sexual health, but it is unknown which normal tissue reactions mediate these symptoms. The aim of this study was to investigate the morphology of the connective tissue of the vaginal wall in cervical cancer survivors treated with radiotherapy. MATERIAL AND METHODS: We recruited 34 cervical cancer survivors treated with radiotherapy and 37 age-matched controls. Via clinical examination the degree of vaginal atrophy and pelvic fibrosis were estimated. We collec...
Source: Acta Oncologica - January 13, 2017 Category: Cancer & Oncology Authors: Hofsjö A, Bohm-Starke N, Blomgren B, Jahren H, Steineck G, Bergmark K Tags: Acta Oncol Source Type: research

Visual outcome, endocrine function and tumor control after fractionated stereotactic radiation therapy of craniopharyngiomas in adults: findings in a prospective cohort.
CONCLUSIONS: FSRT was relatively safe in this prospective cohort of craniopharyngiomas, with only one case of radiation-induced optic neuropathy and no case of new endocrinopathy. Tumor control rate was acceptable. PMID: 28084862 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 13, 2017 Category: Cancer & Oncology Authors: Astradsson A, Munck Af Rosenschöld P, Feldt-Rasmussen U, Poulsgaard L, Wiencke AK, Ohlhues L, Engelholm SA, Broholm H, Hansen Møller E, Klose M, Roed H, Juhler M Tags: Acta Oncol Source Type: research

Population-based experience on primary central nervous system lymphoma 2000-2012: the incidence is increasing.
CONCLUSION: In this population-based study we could confirm the previously described increased incidence of PCNSL. The prognosis remains poor despite the inclusion of treatment with rituximab during the study period. A high proportion of the patients had a history of an autoimmune or inflammatory disease not previously described but there was no increase during the study period. PMID: 28084866 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 13, 2017 Category: Cancer & Oncology Authors: Enblad G, Martinsson G, Baecklund E, Hesselager G, Sundström C, Amini RM, Hagberg H Tags: Acta Oncol Source Type: research

Patient-reported outcomes in cancer survivorship.
We describe additional PRO instruments that assess unmet needs, interpersonal relationship issues, and psychosocial and financial problems. Published studies using these instruments have identified issues commonly faced by cancer survivors worldwide. Discussion and summary: While PROs are increasingly used in research, further efforts are needed to integrate PRO assessment into routine clinical care, so that timely and accurate assessments can translate into better management of issues - ultimately improving the lives of cancer survivors. PMID: 28084867 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 13, 2017 Category: Cancer & Oncology Authors: Gordon BE, Chen RC Tags: Acta Oncol Source Type: research

Self-reported physical activity behavior of breast cancer survivors during and after adjuvant therapy: 12 months follow-up of two randomized exercise intervention trials.
CONCLUSION: The exercise intervention effectively countervailed the decrease in physical activity during cancer therapy and boosted strength exercise in the months following the intervention, but in the longer term many survivors were insufficiently active. Breast cancer survivors may need continued motivation and practical support tailored to their individual characteristics and physical activity history to incorporate exercise in everyday routine in the long term. PMID: 28084890 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 13, 2017 Category: Cancer & Oncology Authors: Schmidt ME, Wiskemann J, Ulrich CM, Schneeweiss A, Steindorf K Tags: Acta Oncol Source Type: research

Sick leave among parents of children with cancer - a national cohort study.
CONCLUSIONS: Findings confirm that mothers and fathers of children diagnosed with cancer are at higher risk of sickness absence from work, with particularly pronounced risk among bereaved parents. Acquisition of further knowledge is warranted regarding possibilities and constraints of parents trying to combine their work life with caring for both their child and themselves. PMID: 28084892 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 13, 2017 Category: Cancer & Oncology Authors: Hjelmstedt S, Lindahl Norberg A, Montgomery S, Hed Myrberg I, Hovén E Tags: Acta Oncol Source Type: research

Unilateral breast reconstruction after mastectomy - patient satisfaction, aesthetic outcome and quality of life.
Abstract BACKGROUND: An increasing number of women undergo a breast reconstruction (BR) after treatment for breast cancer. The aim of the present study was to evaluate patient-reported esthetic satisfaction, quality of life (QoL), and the association between these, following different types of BR. MATERIALS AND METHODS: All women who underwent unilateral BR in Central Denmark Region between January 2005 and July 2011 were included. Participants were sent a questionnaire package, which included the Body Image Scale, The Beck Depression Inventory, the Impact of Event Scale, and a study-specific patient-reported...
Source: Acta Oncologica - January 13, 2017 Category: Cancer & Oncology Authors: Juhl AA, Christensen S, Zachariae R, Damsgaard TE Tags: Acta Oncol Source Type: research

Factors associated with reduced functional outcome and quality of life in patients having limb-sparing surgery for soft tissue sarcomas - a national multicenter study of 128 patients.
Abstract BACKGROUND: Limb-sparing surgery for sarcomas has become possible in most cases. However, the impact of the procedure on the functional outcome has only been investigated in a few studies. The aim of this study has been to identify tumor- and patient-related factors associated with reduced functional outcome and quality of life after limb-sparing surgery in soft tissue sarcoma patients. MATERIAL AND METHODS: In total, 128 patients (mean age = 58, female/male = 54/74) who were treated with limb-sparing surgery without bone resection for soft tissue sarcomas in Denmark durin...
Source: Acta Oncologica - January 12, 2017 Category: Cancer & Oncology Authors: Saebye C, Fugloe HM, Nymark T, Safwat A, Petersen MM, Baad-Hansen T, Krarup-Hansen A, Keller J Tags: Acta Oncol Source Type: research

Bone mineral density is close to normal for age in long-term lymphoma survivors treated with high-dose therapy with autologous stem cell transplantation.
CONCLUSION: BMD was close to normal for age in this population of long-term lymphoma survivors treated with HDT-ASCT. PMID: 28077016 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 12, 2017 Category: Cancer & Oncology Authors: Seland M, Smeland KB, Bjøro T, Falk RS, Fosså SD, Gjesdal CG, Godang K, Holte H, Svartberg J, Syversen U, Bollerslev J, Kiserud CE Tags: Acta Oncol Source Type: research

Adolescent and young adult (AYA) lymphoma survivors report lower health-related quality of life compared to a normative population: results from the PROFILES registry.
This study was part of a longitudinal, population-based survey among lymphoma survivors diagnosed between 1999 and 2012. The AYA survivor sample (18-39 years at time diagnosis) was compared to a sex- and age-matched normative population on HRQoL (EORTC-QLQ-C30) and psychological distress (HADS). Multiple linear regression analyses were conducted to determine factors associated with HRQoL among survivors. RESULTS: One hundred and ninety-eight AYA lymphoma survivors (58%) responded to the study invitation. Compared to an age- and sex-matched normative population (N = 380), significantly and clinically rele...
Source: Acta Oncologica - January 12, 2017 Category: Cancer & Oncology Authors: Husson O, Prins JB, Kaal SE, Oerlemans S, Stevens WB, Zebrack B, van der Graaf WT, van de Poll-Franse LV Tags: Acta Oncol Source Type: research

Patient factors and quality of life outcomes differ among four subgroups of oncology patients based on symptom occurrence.
CONCLUSION: Distinct subgroups of oncology patients can be identified based on symptom occurrence rates. Patient characteristics that are associated with these subgroups can be used to identify patients who are at greater risk for multiple co-occurring symptoms and diminished QoL, so that these patients can be offered appropriate symptom management interventions. PMID: 28077018 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 12, 2017 Category: Cancer & Oncology Authors: Astrup GL, Hofsø K, Bjordal K, Guren MG, Vistad I, Cooper B, Miaskowski C, Rustøen T Tags: Acta Oncol Source Type: research

Patient empowerment: a systematic review of questionnaires measuring empowerment in cancer patients.
CONCLUSION: Our study provides an overview of the available questionnaires, which can be used by researchers and practitioners who wish to measure the concept of empowerment among cancer patients. Very few questionnaires were explicitly developed to explore empowerment, and the review brings to light a significant lack of questionnaires that measure patient empowerment comprehensively. PMID: 28077053 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 12, 2017 Category: Cancer & Oncology Authors: Eskildsen NB, Joergensen CR, Thomsen TG, Ross L, Dietz SM, Groenvold M, Johnsen AT Tags: Acta Oncol Source Type: research

Association between late effects assessed by physicians and quality of life reported by head-and-neck cancer survivors.
CONCLUSION: Physician-assessed moderate to severe hoarseness and mild, moderate, or severe dysphagia are associated with clinically relevant decreases in patient-reported quality of life and functioning. Fibrosis and xerostomia of any severity were not associated with changes in any scale of functioning in this study population. PMID: 28079429 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 12, 2017 Category: Cancer & Oncology Authors: Daugaard R, Kjaer T, Johansen C, Christiansen J, Andersen E, Nielsen AL, Dalton SO Tags: Acta Oncol Source Type: research

Multimodal prehabilitation improves functional capacity before and after colorectal surgery for cancer: a five-year research experience.
Abstract BACKGROUND: Multimodal prehabilitation is a preoperative conditioning intervention in form of exercise, nutritional assessment, whey protein supplementation, and anxiety-coping technique. Despite recent evidence suggesting that prehabilitation could improve functional capacity in patients undergoing colorectal surgery for cancer, all studies were characterized by a relatively small sample size. The aim of this study was to confirm what was previously found in three small population trials. MATERIAL AND METHODS: Data of 185 participants enrolled in a pilot single group study and two randomized control...
Source: Acta Oncologica - January 12, 2017 Category: Cancer & Oncology Authors: Minnella EM, Bousquet-Dion G, Awasthi R, Scheede-Bergdahl C, Carli F Tags: Acta Oncol Source Type: research

Detection of recurrence in early stage endometrial cancer - the role of symptoms and routine follow-up.
Abstract BACKGROUND: Considerable controversy remains as to the optimal organization of endometrial cancer follow-up. AIM: To evaluate the relationship between the way recurrence was detected and survival after treatment for endometrial cancer. Further, to identify characteristics associated with a pre-scheduled examination in women with symptomatic recurrence. MATERIAL AND METHODS: All women with early stage endometrial cancer during 2005-2009 were included in a population-based historical cohort derived from the Danish Gynecological Cancer Database. Women diagnosed with recurrence within three years af...
Source: Acta Oncologica - January 12, 2017 Category: Cancer & Oncology Authors: Jeppesen MM, Mogensen O, Hansen DG, Iachina M, Korsholm M, Jensen PT Tags: Acta Oncol Source Type: research

FAMily-Oriented Support (FAMOS): development and feasibility of a psychosocial intervention for families of childhood cancer survivors.
CONCLUSION: The results indicate that the FAMOS intervention is feasible in terms of recruitment, retention, and acceptability. The effects of the intervention on post-traumatic stress, depression, anxiety, family functioning, and quality of life will be reported after the nationwide RCT has been completed. PMID: 28080169 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 12, 2017 Category: Cancer & Oncology Authors: Salem H, Johansen C, Schmiegelow K, Winther JF, Wehner PS, Hasle H, Rosthøj S, Kazak AE, E Bidstrup P Tags: Acta Oncol Source Type: research

Combination of adalimumab with lower dose of methylprednisolone in Erdheim-Chester disease with systemic involvement.
PMID: 28080175 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 12, 2017 Category: Cancer & Oncology Authors: Jia X, Ning X, Bai Q, Leng N, Wang S, Wang X, Yang S Tags: Acta Oncol Source Type: research

Long-term effects on the incidence of second primary cancers in a randomized trial of two and five years of adjuvant tamoxifen.
CONCLUSION: Further studies of the effects of tamoxifen on the risk of different histological types of lung cancer are needed. PMID: 28080180 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 12, 2017 Category: Cancer & Oncology Authors: Rosell J, Nordenskjöld B, Bengtsson NO, Fornander T, Hatschek T, Lindman H, Malmström PO, Wallgren A, Stål O, Carstensen J Tags: Acta Oncol Source Type: research

Conceptualizing patient empowerment in cancer follow-up by combining theory and qualitative data.
CONCLUSION: We conceptualized PE based on Zimmerman's theory and empirical data to contextualize the concept in cancer follow-up. When developing a patient reported outcome measure measuring PE for this group of patients, one needs to be attentive to differences in wishes regarding mastery. PMID: 28080181 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 12, 2017 Category: Cancer & Oncology Authors: Johnsen AT, Eskildsen NB, Thomsen TG, Grønvold M, Ross L, Jørgensen CR Tags: Acta Oncol Source Type: research

Satisfaction with sex life in sexually active heterosexual couples dealing with breast cancer: a nationwide longitudinal study.
CONCLUSION: Satisfaction with sex life in sexually active couples dealing with BC needs to be seen as a couple issue. Health professionals should take the partner into account when addressing sexuality issues. Couples' functioning and relationship-related factors may be promising targets for couple interventions. PMID: 28080186 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 12, 2017 Category: Cancer & Oncology Authors: Rottmann N, Gilså Hansen D, dePont Christensen R, Hagedoorn M, Frisch M, Nicolaisen A, Kroman N, Flyger H, Johansen C Tags: Acta Oncol Source Type: research

Early life risk factors for testicular cancer: a case-cohort study based on the Copenhagen School Health Records Register.
CONCLUSION: This study confirmed the robustness of the association between cryptorchidism and testicular cancer even after adjustment for birth weight and birth order. Furthermore, the study showed an inverse association between birth weight and testicular cancer. PMID: 28080187 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 12, 2017 Category: Cancer & Oncology Authors: Piltoft JS, Larsen SB, Dalton SO, Johansen C, Baker JL, Cederkvist L, Andersen I Tags: Acta Oncol Source Type: research

The ADAPP trial: a two-year longitudinal multidisciplinary intervention study for prostate cancer frail patients on androgen deprivation associated to curative radiotherapy.
CONCLUSION: The expected side effects of AD and RT were not observed in frail PC patients who followed this multidisciplinary care program. PMID: 28075176 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 11, 2017 Category: Cancer & Oncology Authors: Mareschal J, Weber K, Rigoli P, Biason E, Frambati L, Gotteland C, Zilli T, Pichard C, Miralbell R Tags: Acta Oncol Source Type: research

Accelerated or conventional whole brain irradiation of malignant melanoma.
PMID: 28075181 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 11, 2017 Category: Cancer & Oncology Authors: Hultborn R, Sand J, Kinhult S, Lundgren L, Stierner U, Turesson I, Albertsson P Tags: Acta Oncol Source Type: research

Systematic evaluation of lung tumor motion using four-dimensional computed tomography.
CONCLUSION: Lung tumor movements were generally larger in the IS direction and the motion amplitude in this direction increased for tumors located in the middle and lower parts of the lungs. Motions in LR or AP showed no such relation. Tumor size was not found to have any correlation with the motion amplitude in any direction. The motion pattern of a lung tumor in any direction is best described with a squared sinusoidal function independently of the tumor size or tumor location. PMID: 28075183 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 11, 2017 Category: Cancer & Oncology Authors: Sarudis S, Karlsson Hauer A, Nyman J, Bäck A Tags: Acta Oncol Source Type: research

Validation of an established prognostic score after re-irradiation of recurrent glioma.
Abstract BACKGROUND: Re-irradiation (Re-RT) is offered widely in clinical routine, and has been established as a key element in the treatment of recurrent gliomas. At our center, generally re-resection is performed widely by an experienced neurosurgical team. Thus, Re-RT mostly offered to patients with macroscopic residuals or irresectable lesions, is applied later compared to other centers. Therefore, we sought to validate the Combs Prognostic Score developed in 2012 using our independent patient cohort. PATIENTS AND METHODS: We included 199 patients treated from 2002 until April 2016 for recurrent glioma at...
Source: Acta Oncologica - January 11, 2017 Category: Cancer & Oncology Authors: Kessel KA, Hesse J, Straube C, Zimmer C, Schmidt-Graf F, Schlegel J, Meyer B, Combs SE Tags: Acta Oncol Source Type: research

Hydrogel rectum-prostate spacers mitigate the uncertainties in proton relative biological effectiveness associated with anterior-oblique beams.
CONCLUSION: Typically, rectal spacers enabled the generation of anterior beam proton plans that appeared robust to modeled variation in RBE. However, further analysis of day-to-day robustness would be required prior to a clinical implementation of AO proton beams. Such beams offer almost complete femoral head sparing, but their broader value relative to IMRT and SB protons remains unclear. PMID: 28075206 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 11, 2017 Category: Cancer & Oncology Authors: Underwood TS, Voog JC, Moteabbed M, Tang S, Soffen E, Cahlon O, Lu HM, Zietman AL, Efstathiou JA, Paganetti H Tags: Acta Oncol Source Type: research

Perceived needs for different components in a rehabilitation program among cancer survivors with chronic fatigue compared to survivors without chronic fatigue.
Thorsen L Abstract BACKGROUND: Knowledge about the user' needs is important to develop targeted rehabilitation for cancer patients with chronic fatigue (CF). The aims of the study were to examine prevalence of CF in cancer survivors attending an one-week inpatient educational program (IEP) and to identify characteristics of those with CF. Further to examine the perceived needs for different components in a rehabilitation program, need of complex rehabilitation (at least two components) and aspects of health-related quality of life (HRQoL) among survivors with CF versus those without CF. MATERIAL AND METHODS:...
Source: Acta Oncologica - January 11, 2017 Category: Cancer & Oncology Authors: Gjerset GM, Loge JH, Kiserud CE, Fosså SD, Gudbergsson SB, Oldervoll LM, Wisløff T, Thorsen L Tags: Acta Oncol Source Type: research

Knowledge-based planning for stereotactic radiotherapy of peripheral early-stage lung cancer.
PMID: 28067088 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 9, 2017 Category: Cancer & Oncology Authors: Delaney AR, Dahele M, Tol JP, Slotman BJ, Verbakel WF Tags: Acta Oncol Source Type: research

Corrigendum.
Authors: PMID: 28067091 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 9, 2017 Category: Cancer & Oncology Tags: Acta Oncol Source Type: research

Promoting a culture of prehabilitation for the surgical cancer patient.
CONCLUSION: Preliminary findings indicate that a group of interventions such as exercise, nutrition and anxiety reduction in the preoperative period can complement the enhanced recovery program and facilitate the return to baseline activities of daily living. It is not clear at this stage whether the preoperative increase in functional capacity mitigates the burden of postoperative morbidities and subsequent cancer therapies. Therefore, more research is warranted. PMID: 28067101 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 9, 2017 Category: Cancer & Oncology Authors: Carli F, Gillis C, Scheede-Bergdahl C Tags: Acta Oncol Source Type: research

Preoperative modifiable risk factors in colorectal surgery: an observational cohort study identifying the possible value of prehabilitation.
Abstract BACKGROUND: Colorectal cancer (CRC) is the second most prevalent type of cancer in the world. Surgery is the most common therapeutic intervention, and associated with 20-40% reduction in physiological and functional capacity. Postoperative complications occur in up to 50% of patients resulting in higher mortality rates and greater hospital costs. The number and severity of complications is closely related to patients' preoperative performance status. The aim of this study was to identify the most important preoperative modifiable risk factors that could be part of a multimodal prehabilitation program. ...
Source: Acta Oncologica - January 9, 2017 Category: Cancer & Oncology Authors: van Rooijen S, Carli F, Dalton SO, Johansen C, Dieleman J, Roumen R, Slooter G Tags: Acta Oncol Source Type: research

Prognostic impact of pretreatment neutrophil-to-lymphocyte ratio in castration-resistant prostate cancer patients treated with first-line docetaxel.
CONCLUSION: In this retrospective series, metastatic CRPC patients who started first-line docetaxel with a low pretreatment NLR had a significantly better survival. In addition to known prognostic factors, NLR can be useful to improve prognostic evaluation of patients in this setting. PMID: 28068151 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 9, 2017 Category: Cancer & Oncology Authors: Buttigliero C, Pisano C, Tucci M, Vignani F, Bertaglia V, Iaconis D, Guglielmini P, Numico G, Scagliotti GV, Di Maio M Tags: Acta Oncol Source Type: research

The cost of survival: an exploration of colorectal cancer survivors' experiences of pain.
DISCUSSION: Pain was experienced by almost two fifths of CRC survivors up to five years after treatment and was associated with poorer SRH and QoL. In light of these findings, healthcare professionals must endeavor to manage cancer survivors' needs in a manner which is cognizant of the burden of pain and in the context of other symptoms and morbidities experienced by long-term cancer survivors. PMID: 28068155 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 9, 2017 Category: Cancer & Oncology Authors: Drury A, Payne S, Brady AM Tags: Acta Oncol Source Type: research

Follow-up after rectal cancer: developing and testing a novel patient-led follow-up program. Study protocol.
Discussion and perspectives: The results of the FURCA study will strengthen the evidence base for RC follow-up, and qualify the ongoing transformation in cancer follow-up programs. PMID: 28068158 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 9, 2017 Category: Cancer & Oncology Authors: Hovdenak Jakobsen I, Juul T, Bernstein I, Christensen P, Jensen FS, Johansen C, Lindhardt Larsen S, Laurberg S, Madsen MR, Thorlacius-Ussing O, Vind Thaysen H Tags: Acta Oncol Source Type: research

Quality of life in long-term and very long-term cancer survivors versus population controls in Germany.
The objective of our study is to: (1) compare QoL of long-term cancer survivors and population norms; and (2) assess whether any deficits in QoL of survivors observed 5-10 years past diagnosis persist beyond the 10th year past diagnosis. METHODS: In total 6952 long-term cancer survivors (5-16 years past diagnosis of breast, colorectal, or prostate cancer) from Germany recruited in the context of the population-based CAESAR + study were compared with 1878 population-based controls without a history of cancer. QoL was assessed with the EORTC QLQ-C30. Differences in QoL between survivors and controls were a...
Source: Acta Oncologica - January 5, 2017 Category: Cancer & Oncology Authors: Arndt V, Koch-Gallenkamp L, Jansen L, Bertram H, Eberle A, Holleczek B, Schmid-Höpfner S, Waldmann A, Zeissig SR, Brenner H Tags: Acta Oncol Source Type: research

Methodological, biological and clinical aspects of circulating free DNA in metastatic colorectal cancer.
CONCLUSION: This paper had gathered the most recent literature on several aspects of cfDNA in mCRC, including methodological, biological and clinical aspects, and discussed the large clinical potential in this specific setting, which needs to be validated in carefully designed prospective studies in statistically relevant cohorts. PMID: 28010185 [PubMed - in process] (Source: Acta Oncologica)
Source: Acta Oncologica - December 26, 2016 Category: Cancer & Oncology Authors: Spindler KG Tags: Acta Oncol Source Type: research

New frontiers in couple-based interventions in cancer care: refining the prescription for spousal communication.
CONCLUSION: In order push this field forward, we need to develop a more nuanced view of couples' communication that acknowledges that there are multiple ways to talk, different aspects of the cancer experience to talk about, and preexisting communication patterns and preferences for different couples that may influence the utility of talk. Interventions that replace the unilateral and generic prescription to talk openly about cancer with targeted questions that prompt reflection on couples' unique strengths, preexisting communication patterns and support resources may thus help bolster the impact of couple-based interventi...
Source: Acta Oncologica - December 12, 2016 Category: Cancer & Oncology Authors: Badr H Tags: Acta Oncol Source Type: research

Risk of second cancers in survivors of prolymphocytic leukemia: a SEER data analysis.
PMID: 27924652 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - December 7, 2016 Category: Cancer & Oncology Authors: El-Fattah MA Tags: Acta Oncol Source Type: research

Healthcare resource use, comorbidity, treatment and clinical outcomes for patients with primary intracranial tumors: a Swedish population-based register study.
CONCLUSIONS: Age, comorbidity and high-grade gliomas, but not sex, were associated with decreased survival and increased use of healthcare resources. Fewer patients than aimed for in national guidelines received care according to specified lead times. The analysis of comprehensive population-based register data can be used to improve future care processes and outcomes. PMID: 27924653 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - December 7, 2016 Category: Cancer & Oncology Authors: Bergqvist J, Iderberg H, Mesterton J, Bengtsson N, Wettermark B, Henriksson R Tags: Acta Oncol Source Type: research

Assessment of ethnic differences in sunitinib outcome between Caucasian and Asian patients with metastatic renal cell carcinoma: a meta-analysis.
CONCLUSION: Ethnic differences in adverse events of sunitinib in mRCC patients existed and dose adjustment in Asian patients may be considered. PMID: 27924664 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - December 7, 2016 Category: Cancer & Oncology Authors: Liu X, Fiocco M, Swen JJ, Guchelaar HJ Tags: Acta Oncol Source Type: research