Towards a novel small animal proton irradiation platform: the SIRMIO project.
Würl M Abstract Background: Precision small animal radiotherapy research is a young emerging field aiming to provide new experimental insights into tumor and normal tissue models in different microenvironments, to unravel complex mechanisms of radiation damage in target and non-target tissues and assess efficacy of novel therapeutic strategies. For photon therapy, modern small animal radiotherapy research platforms have been developed over the last years and are meanwhile commercially available. Conversely, for proton therapy, which holds potential for an even superior outcome than photon therapy, no commerci...
Source: Acta Oncologica - July 4, 2019 Category: Cancer & Oncology Authors: Parodi K, Assmann W, Belka C, Bortfeldt J, Clevert DA, Dedes G, Kalunga R, Kundel S, Kurichiyanil N, Lämmer P, Lascaud J, Lauber K, Lovatti G, Meyer S, Nitta M, Pinto M, Safari MJ, Schnürle K, Schreiber J, Thirolf PG, Wieser HP, Würl M Tags: Acta Oncol Source Type: research

Radiation tattoos mimicking melanoma: a clinical observation.
PMID: 31271092 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - July 4, 2019 Category: Cancer & Oncology Authors: Nazarian RS, Amin B, Papalezova K, Ohri N, McLellan BN Tags: Acta Oncol Source Type: research

Evaluation of proton and photon dose distributions recalculated on 2D and 3D Unet-generated pseudoCTs from T1-weighted MR head scans.
Conclusions: Image analysis revealed a slight advantage of 2D Unets compared to 3D Unets. Similar dose calculation performance was reached for the 2D and 3D network. PMID: 31271093 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - July 4, 2019 Category: Cancer & Oncology Authors: Neppl S, Landry G, Kurz C, Hansen DC, Hoyle B, Stöcklein S, Seidensticker M, Weller J, Belka C, Parodi K, Kamp F Tags: Acta Oncol Source Type: research

Survival after stereotactic radiotherapy in patients with early-stage non-small cell lung cancer.
Conclusions: The OS was influenced by age, but the study suggests that a cut point of 75 year is inappropriate in evaluating the effect of old age on survival. Poor PS was associated with poor OS. CCI influenced OS, but not LCSS, which was only affected by PS and tumor size. PMID: 31271094 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - July 4, 2019 Category: Cancer & Oncology Authors: Hansen O, Kristiansen C, Nielsen M, Schytte T, Starup Jeppesen S Tags: Acta Oncol Source Type: research

Intensity modulated proton therapy plan generation in under ten seconds.
Abstract Background: Treatment planning for intensity modulated proton therapy (IMPT) can be significantly improved by reducing the time for plan calculation, facilitating efficient sampling of the large solution space characteristic of IMPT treatments. Additionally, fast plan generation is a key for online adaptive treatments, where the adapted plan needs to be ideally available in a few seconds. However, plan generation is a computationally demanding task and, although dose restoration methods for adaptive therapy have been proposed, computation times remain problematic. Material and methods: IMPT plan generatio...
Source: Acta Oncologica - July 4, 2019 Category: Cancer & Oncology Authors: Matter M, Nenoff L, Meier G, Weber DC, Lomax AJ, Albertini F Tags: Acta Oncol Source Type: research

An investigative expansion of a competing risk model for first failure site in locally advanced non-small cell lung cancer.
aring;rd L Abstract Introduction: We hypothesized that gross tumor volume (GTV) of primary tumor (GTVT) and nodal volumes (GTVN) were predictors of first failure site in non-small cell lung cancer (NSCLC). We aimed at also comparing the prognostic model's complexity to its ability to generate absolute risk predictions with emphasis on variables available at the time of diagnosis. Materials and methods: Three hundred and forty-two patients treated with definitive chemoradiotherapy (CRT) for adenocarcinoma (AC) or squamous cell carcinoma (SCC) in 2009-2017 were analyzed. Clinical data, standardized uptake values on ...
Source: Acta Oncologica - July 4, 2019 Category: Cancer & Oncology Authors: Lacoppidan T, Vogelius IR, Pøhl M, Strange M, Persson GF, Nygård L Tags: Acta Oncol Source Type: research

Influence of mutagenic versus non-mutagenic pre-operative chemotherapy on the immune infiltration of residual breast cancer.
Conclusions: Significant increase of StrTIL in the residual disease was observed in patients treated with the highly (platinum), moderately (cyclophosphamide) and marginally mutagenic chemotherapeutic agents (taxane, anthracycline). Increase in StrTIL in residual cancer compared to pretreatment tumor tissue is associated with improved distant metastasis-free survival in cases with HR negative breast carcinoma. PMID: 31271119 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - July 4, 2019 Category: Cancer & Oncology Authors: Tőkés AM, Rusz O, Cserni G, Tóth E, Rubovszky G, Tőkés T, Vízkeleti L, Reiniger L, Kószó R, Kahán Z, Kulka J, Donia M, Vörös A, Szallasi Z Tags: Acta Oncol Source Type: research

Factors determining the effect of prophylactic cranial irradiation (PCI) in patients with stage-III nonsmall cell lung cancer: exploratory subgroup analyses of the NVALT-11/DLCRG-02 phase-III study.
PMID: 31256737 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - July 1, 2019 Category: Cancer & Oncology Authors: Witlox WJA, Ramaekers BLT, Groen HJM, Dingemans AM, Praag J, Belderbos J, van der Noort V, van Tinteren H, Joore MA, De Ruysscher DKM Tags: Acta Oncol Source Type: research

LINAC based stereotactic radiosurgery for multiple brain metastases: guidance for clinical implementation.
Abstract Introduction: Stereotactic radiosurgery (SRS) is a promising treatment option for patients with multiple brain metastases (BM). Recent technical advances have made LINAC based SRS a patient friendly technique, allowing for accurate patient positioning and a short treatment time. Since SRS is increasingly being used for patients with multiple BM, it remains essential that SRS be performed with the highest achievable quality in order to prevent unnecessary complications such as radionecrosis. The purpose of this article is to provide guidance for high-quality LINAC based SRS for patients with BM, with a foc...
Source: Acta Oncologica - July 1, 2019 Category: Cancer & Oncology Authors: Hartgerink D, Swinnen A, Roberge D, Nichol A, Zygmanski P, Yin FF, Deblois F, Hurkmans C, Ong CL, Bruynzeel A, Aizer A, Fiveash J, Kirckpatrick J, Guckenberger M, Andratschke N, de Ruysscher D, Popple R, Zindler J Tags: Acta Oncol Source Type: research

Improving the prognosis for lung cancer patients.
PMID: 31257968 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - July 1, 2019 Category: Cancer & Oncology Authors: Clausen MM, Langer SW Tags: Acta Oncol Source Type: research

Arsenic trioxide and tetraarsenic oxide induce cytotoxicity and have a synergistic effect with cisplatin in paclitaxel-resistant ovarian cancer cells.
In this study, the cytotoxicity of arsenic compounds on ovarian cancer cell lines and the anticancer activity of the combination of arsenic compounds and cisplatin IN chemoresistant ovarian cancer cells were investigated. Methods: We investigated the cytotoxicity of As2O3 and As4O6 and their combinations with cisplatin in the paclitaxel-sensitive ovarian cancer cell lines SKOV3ip1 and HeyA8 and paclitaxel-resistant ovarian cancer cell lines SKOV3TRip2 and HeyA8-MDR. Growth and apoptosis were evaluated by MTT assay and annexin V assay using flow cytometry, respectively. For detection of apoptotic cells, immunofluorescence w...
Source: Acta Oncologica - July 1, 2019 Category: Cancer & Oncology Authors: Byun JM, Lee DS, Landen CN, Kim DH, Kim YN, Lee KB, Sung MS, Park SG, Jeong DH Tags: Acta Oncol Source Type: research

Towards FLASH proton therapy: the impact of treatment planning and machine characteristics on achievable dose rates.
Conclusion: FLASH dose rates were not achieved for conventional planning and clinical spot-scanning machines. As such, increased spot-wise beam intensities, spot-reduced planning, hypofractionation and arc-shoot-through plans were required to achieve FLASH compatible dose rates. PMID: 31241377 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - June 26, 2019 Category: Cancer & Oncology Authors: van de Water S, Safai S, Schippers JM, Weber DC, Lomax AJ Tags: Acta Oncol Source Type: research

Relationship between patient and physician-rated xerostomia and dose distribution to the oral cavity and salivary glands for head and neck cancer patients after radiotherapy.
Conclusion: Patients tended to report higher scores of xerostomia than the physician. PCA indicated a complex relation between doses to the OAR and xerostomia scores, showing e.g., that reducing doses in one organ was on the expense of increased dose to another organ. PMID: 31241381 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - June 26, 2019 Category: Cancer & Oncology Authors: Kaae JK, Johnsen L, Hansen CR, Kristensen MH, Brink C, Eriksen JG Tags: Acta Oncol Source Type: research

A theoretical investigation of adequate range uncertainty margins in proton treatment planning to preserve tumor control probability.
Conclusion: The details of the underlying cancer cell distribution characteristics do impact the adequate dose arrangements, and for opposing beams a non-conventional dose distribution shape is often advantageous. PMID: 31241385 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - June 26, 2019 Category: Cancer & Oncology Authors: Taasti VT, Jeong J, Jackson A, Deasy JO Tags: Acta Oncol Source Type: research

First clinical experiences with a high field 1.5 T MR linac.
Conclusion: MRL treatments, including daily MRIs, plan adaptation, and accurate dose delivery, are possible within a clinically acceptable timeframe and well tolerated by the patients. PMID: 31241387 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - June 26, 2019 Category: Cancer & Oncology Authors: Bertelsen AS, Schytte T, Møller PK, Mahmood F, Riis HL, Gottlieb KL, Agergaard SN, Dysager L, Hansen O, Gornitzka J, Veldhuizen E, ODwyer DB, Christiansen RL, Nielsen M, Jensen HR, Brink C, Bernchou U Tags: Acta Oncol Source Type: research

Assessing the size of large colorectal polyps.
PMID: 31241388 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - June 26, 2019 Category: Cancer & Oncology Authors: Rubio CA Tags: Acta Oncol Source Type: research

Bringing Europe together in building clinical evidence for proton therapy - the EPTN-ESTRO-EORTC endeavor.
PMID: 31241391 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - June 26, 2019 Category: Cancer & Oncology Authors: Weber DC, Grau C, Lim PS, Georg D, Lievens Y Tags: Acta Oncol Source Type: research

Cancer patients' interest in participating in cancer rehabilitation.
Conclusions: The interest of cancer rehabilitation of all approached patients in this study were 21%. Most interested were women, young patients, university educated and those who received their diagnosis ≥12 months earlier. About 30% of the participating cancer patients reported an interest of information and supportive groups, physical training and support from a hospital social worker. Patients with low level of education reported a low interest in CR. There are limitations in rehabilitation accessibility and that might affect a person's motivation to participate in this study. PMID: 31241428 [PubMed - as suppli...
Source: Acta Oncologica - June 26, 2019 Category: Cancer & Oncology Authors: Ohlsson-Nevo E, Alkebro I, Ahlgren J Tags: Acta Oncol Source Type: research

Neoadjuvant stereotactic body radiation therapy for nonmetastatic pancreatic adenocarcinoma.
Abstract Background: Neoadjuvant therapy is a strategy for resectable and borderline resectable pancreatic cancer, but a consensus approach regarding optimal management is undetermined. Neoadjuvant options include chemotherapy with/without radiotherapy. Stereotactic body radiation therapy (SBRT) is a novel radiation technique that may provide benefit over conventionally fractionated radiation therapy (CFRT) in the neoadjuvant setting. The purpose of the present study is to determine neoadjuvant treatment with SBRT to other neoadjuvant treatment options for patients with resectable pancreatic cancer. Material and m...
Source: Acta Oncologica - June 25, 2019 Category: Cancer & Oncology Authors: Jiang W, Haque W, Verma V, Butler EB, Teh BS Tags: Acta Oncol Source Type: research

Five-year oncological outcomes after selective neoadjuvant radiotherapy for resectable rectal cancer.
Conclusions: Patients selected for SCRT had a lower rate of local recurrence than patients selected for surgery alone, but were more likely to develop distant metastasis. There was no difference in overall survival. With low local recurrence rates, distant metastasis is the predominant risk for patients with resectable rectal cancer. PMID: 31237192 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - June 25, 2019 Category: Cancer & Oncology Authors: Banwell VC, Phillips HA, Duff MJ, Speake D, McLean C, Williams LJ, He Y, Paterson HM Tags: Acta Oncol Source Type: research

Pre-operative plasma cell-free circulating tumor DNA and serum protein tumor markers as predictors of lung adenocarcinoma recurrence.
H, Planck M Abstract Background: Lung cancer patients have a risk of recurrence even after curatively intended surgery. Cell-free circulating tumor DNA (ctDNA) and circulating tumor marker measurements are easily accessible through peripheral blood and could potentially identify patients with worse prognosis. The aim of this study was to examine ctDNA in pre-operative plasma and the role of tumor markers in pre-operative serum for their predictive potential on risk of tumor recurrence. Methods: Mutation analysis by 26-gene targeted sequencing was performed on 157 lung adenocarcinomas (ACs) from patients surgically...
Source: Acta Oncologica - June 24, 2019 Category: Cancer & Oncology Authors: Isaksson S, George AM, Jönsson M, Cirenajwis H, Jönsson P, Bendahl PO, Brunnström H, Staaf J, Saal LH, Planck M Tags: Acta Oncol Source Type: research

Outside the box of immunotherapy - new hope for patients with advanced urothelial cancer.
e;n A PMID: 31232133 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - June 24, 2019 Category: Cancer & Oncology Authors: Ullén A Tags: Acta Oncol Source Type: research

Adjuvant radiotherapy-induced cardiac changes among patients with early breast cancer: a three-year follow-up study.
In this study, we evaluate the evolution of cardiac changes during a three-year follow-up after adjuvant breast radiotherapy (RT). Methods: Sixty patients with left-sided and 20 patients with right-sided early stage breast cancer without chemotherapy were included in this prospective study. Echocardiography and cardiac biomarkers were evaluated before, immediately after and 3 years after RT. Radiation doses to cardiac structures were calculated. Results: In echocardiography, left ventricle (LV) systolic measurements had impaired at 3 years compared to baseline: the mean global longitudinal strain (GLS) worsened from -18&th...
Source: Acta Oncologica - June 20, 2019 Category: Cancer & Oncology Authors: Skyttä T, Tuohinen S, Luukkaala T, Virtanen V, Raatikainen P, Kellokumpu-Lehtinen PL Tags: Acta Oncol Source Type: research

Quality assessment criteria: psychometric properties of measurement tools for cancer related fatigue.
Conclusion: Further psychometric testing is required for other scales. Developing a universally-defined tool kit for the assessment of cancer-related fatigue may help clarify the concept of fatigue and promote a systematic approach to fatigue measurement. PMID: 31204538 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - June 17, 2019 Category: Cancer & Oncology Authors: Al Maqbali M, Hughes C, Gracey J, Rankin J, Dunwoody L, Hacker E Tags: Acta Oncol Source Type: research

Deformable image registration for radiation therapy: principle, methods, applications and evaluation.
Conclusions: DIR is increasingly important in RT applications, from planning to toxicity prediction. DIR is routinely used to reduce the workload of contour propagation. However, its use for complex dosimetric applications must be carefully evaluated by combining quantitative and qualitative analyses. PMID: 31155990 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - June 3, 2019 Category: Cancer & Oncology Authors: Rigaud B, Simon A, Castelli J, Lafond C, Acosta O, Haigron P, Cazoulat G, de Crevoisier R Tags: Acta Oncol Source Type: research

Clinical results of proton therapy reirradiation for recurrent nasopharyngeal carcinoma.
Conclusions: Our initial results with the use of modern PT for reirradiation of recurrent NPC patients are encouraging. Favorable LC and OS rates were obtained at the cost of acceptable severe late toxicity. PMID: 31155998 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - June 3, 2019 Category: Cancer & Oncology Authors: Dionisi F, Croci S, Giacomelli I, Cianchetti M, Caldara A, Bertolin M, Vanoni V, Pertile R, Widesott L, Farace P, Schwarz M, Amichetti M Tags: Acta Oncol Source Type: research

Real-world data on PD-1 inhibitor therapy in metastatic melanoma.
Conclusions: The efficacy and safety of PD1 inhibitors in routine clinical practice appear comparable to that described in clinical trials. PMID: 31151362 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - May 31, 2019 Category: Cancer & Oncology Authors: Arheden A, Skalenius J, Bjursten S, Stierner U, Ny L, Levin M, Jespersen H Tags: Acta Oncol Source Type: research

Quantitative analysis of 18-FDG-PET/MRI to assess pathological complete response following neoadjuvant radiochemotherapy in locally advanced rectal cancer. A prospective preliminary study.
z Dueñas V PMID: 31144557 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - May 30, 2019 Category: Cancer & Oncology Authors: Ferri V, Vicente Lopez E, Quijano Collazo Y, Caruso R, Duran Gimenez Rico H, Ielpo B, Diaz Reques E, Fabra Cabrera I, Malavè Cardozo L, Isernia R, Pinna E, Plaza Hernandezv C, Garcerant M, Garcia Cañamaques L, Perez Dueñas V Tags: Acta Oncol Source Type: research

Trends in incidence, treatment and survival of borderline ovarian tumors in the Netherlands: a nationwide analysis.
Conclusions: The incidence of BOTs increased over time from 1993 until 2010 but declined since 2011. This decline may be partly due to changes in the classification of gynecological tumors, as serous BOTs are now more often diagnosed as low grade serous ovarian cancers. Survival is high and has improved since 1993. The risk of a subsequent invasive ovarian carcinoma seems low. PMID: 31135241 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - May 28, 2019 Category: Cancer & Oncology Authors: Schuurman MS, Timmermans M, van Gorp T, de Vijver KKV, Kruitwagen RFPM, Lemmens VEPP, van der Aa MA Tags: Acta Oncol Source Type: research

Autoimmune disease in patients with diffuse large B-cell lymphoma: occurrence and impact on outcome.
Conclusion: There is a high prevalence of AID among patients with DLBCL. AIDs categorized as primarily B-cell mediated (in this study mainly RA, systemic lupus erythematosus and Sjögren's syndrome) may be associated with inferior OS. AID patients may be more prone to neutropenic fever compared to patients without concomitant AID. PMID: 31131659 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - May 25, 2019 Category: Cancer & Oncology Authors: Mörth C, Valachis A, Abu Sabaa A, Marshall K, Hedström G, Flogegård M, Baecklund E, Enblad G Tags: Acta Oncol Source Type: research

Glucose-6-phosphate dehydrogenase deficiency reduces susceptibility to cancer of endodermal origin.
CONCLUSIONS: Our results suggest a reduced susceptibility to develop cancers, mostly of endodermal origin (stomach, colon and liver), but not of ectodermal/mesodermal origin, in carriers of G6PD deficiency. The effects of G6PD deficiency on carcinogenesis need further studies to better understand how cancer cells originating from different germ layers use pentose phosphate pathway to proliferate. PMID: 31109224 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - May 21, 2019 Category: Cancer & Oncology Authors: Pes GM, Errigo A, Soro S, Longo NP, Dore MP Tags: Acta Oncol Source Type: research

Data and basic statistics for surveillance of sociodemographic inequalities in early detection of cancer.
i J PMID: 31106629 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - May 20, 2019 Category: Cancer & Oncology Authors: Strömberg U, Claeson M, Paoli J Tags: Acta Oncol Source Type: research

NordScreen - an interactive tool for presenting cervical cancer screening indicators in the Nordic countries.
CONCLUSIONS: NordScreen is a pilot model for comparable, reliable and accessible cross-country comparisons of cancer screening. Comparability between countries is enhanced by a uniform data structure and standardized calculations. The comparison of coverage rates to national figures shows that the methods used nationally and in the NordScreen project produce similar results. PMID: 31106635 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - May 20, 2019 Category: Cancer & Oncology Authors: Partanen VM, Anttila A, Heinävaara S, Pankakoski M, Sarkeala T, Bzhalava Z, Elfström KM, Tropé A, Skare GB, Thorsteinsdottir S, Ágústsson ÁI, Veerus P, Koreinik L, Dillner J, Lönnberg S Tags: Acta Oncol Source Type: research

Survival after local excision for rectal cancer: a population-based overview of clinical practice and outcome.
PMID: 31106636 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - May 20, 2019 Category: Cancer & Oncology Authors: Verseveld M, de Wilt JHW, Elferink MAG, de Graaf EJR, Verhoef C, Pouwels S, Doornebosch PG Tags: Acta Oncol Source Type: research

Chronic obstructive pulmonary disease and comorbidities' influence on mortality in non-small cell lung cancer patients.
CONCLUSION: Our findings do not suggest that COPD nor other common comorbidities are significantly associated with higher mortality in NSCLC patients. PMID: 31092081 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - May 15, 2019 Category: Cancer & Oncology Authors: Media AS, Persson M, Tajhizi N, Weinreich UM Tags: Acta Oncol Source Type: research

Efficacy and safety of immune checkpoint inhibitors in a Danish real life non-small cell lung cancer population: a retrospective cohort study.
, Schytte T Abstract BACKGROUND: To investigate effect and toxicity of immune checkpoint inhibition (ICI) in a Danish real-life non-small cell lung cancer (NSCLC) population. By including patients underrepresented in clinical trials, such as those with brain metastasis (BM), higher age, more comorbidity and poorer performance status (ECOG), comparison of unselected patients to clinical trial populations is possible. MATERIAL AND METHODS: Real life data were gathered from 118 consecutive NSCLC patients with incurable NSCLC treated with ICI at the Department of Oncology at the University Hospital of Odense, Den...
Source: Acta Oncologica - May 12, 2019 Category: Cancer & Oncology Authors: Bjørnhart B, Hansen KH, Jørgensen TL, Herrstedt J, Schytte T Tags: Acta Oncol Source Type: research

Publishing your trial protocols with Acta Oncologica; your contribution to scientific transparency.
PMID: 31079524 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - May 11, 2019 Category: Cancer & Oncology Authors: Nilbert M, Overgaard J Tags: Acta Oncol Source Type: research

Chemoradiation phase II trials: re-exploring a world of missed opportunities.
CONCLUSIONS: cCRT phase II trials featured severe limitations, with outdated radiation techniques, insufficient reporting of crucial data and a small number of included patients. This certainly limited the impact of conclusions and hindered the development of successful phase III trials. PMID: 31074314 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - May 10, 2019 Category: Cancer & Oncology Authors: Trone JC, Langrand-Escure J, Ollier E, Jmour O, Ben Mrad M, Nevesny S, Lei Q, Benna M, Yazid D, Guy JB, Vallard A, Magné N Tags: Acta Oncol Source Type: research

Radiation-induced brachial plexus toxicity after SBRT of apically located lung lesions.
CONCLUSION: SBRT of apically located lung lesions may cause severe neurological symptoms; for a three-fraction treatment, we suggest that the maximum dose to the plexus should be kept ≤30 Gy (130 Gy BED3). PMID: 31066326 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - May 8, 2019 Category: Cancer & Oncology Authors: Lindberg K, Grozman V, Lindberg S, Onjukka E, Lax I, Lewensohn R, Wersäll P Tags: Acta Oncol Source Type: research

Role of interim and end of treatment positron emission tomography for response assessment and prediction of relapse in posttransplant lymphoproliferative disorder.
CONCLUSIONS: Negative interim and/or negative end of treatment PET identify PTLD patients with low risk of disease recurrence. PMID: 31035840 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - April 29, 2019 Category: Cancer & Oncology Authors: Van Keerberghen CA, Goffin K, Vergote V, Tousseyn T, Verhoef G, Laenen A, Vandenberghe P, Dierickx D, Gheysens O Tags: Acta Oncol Source Type: research

European cancer rehabilitation and survivorship, 2018: one of a kind.
PMID: 31035842 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - April 29, 2019 Category: Cancer & Oncology Authors: Dalton SO, Johansen C Tags: Acta Oncol Source Type: research

Impact of choice of feeding tubes on long-term swallow function following chemoradiotherapy for oropharyngeal carcinoma.
This study evaluates patient-reported swallow function following chemoradiotherapy for oropharyngeal carcinoma in relation to the use of a prophylactic gastrostomy or nasogastric (NG) tube as required. MATERIAL AND METHODS: The MD Anderson Dysphagia Inventory (MDADI) was posted to 204 disease-free patients at least 2 years following chemoradiotherapy for oropharyngeal carcinoma between 2010 and 2014. RESULTS: Overall, 181/204 (89%) patients returned questionnaire at a median of 34 months post-treatment. 97/181 (54%) and 84/181 (46%) were managed with an approach of a prophylactic gastrostomy or NG tube as require...
Source: Acta Oncologica - April 29, 2019 Category: Cancer & Oncology Authors: Prestwich RJD, Murray LJ, Williams GF, Tease E, Taylor L, George C, Cardale K, Dyker KE, Murray P, Sen M, Ramasamy S Tags: Acta Oncol Source Type: research

First-time prescription of enzalutamide in a patient treated with fluindione and digoxin: serial drug interactions.
PMID: 31032691 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - April 27, 2019 Category: Cancer & Oncology Authors: Strobbe G, Pannier D, Villain A, Feutry F, Marliot G Tags: Acta Oncol Source Type: research

TOXview: a novel graphical presentation of cancer treatment toxicity profiles.
CONCLUSION: TOXview provides a new graphical presentation and overview of chemotherapy toxicities. TOXviews can be used to educate physicians about the incidences of AEs of systemic therapy and improve informed decision-making. PMID: 31017020 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - April 24, 2019 Category: Cancer & Oncology Authors: Ngai LL, Ter Veer E, van den Boorn HG, van Herk EH, van Kleef JJ, van Oijen MGH, van Laarhoven HWM Tags: Acta Oncol Source Type: research

Comparison of 3D conformal radiation therapy and intensity-modulated radiation therapy in patients with endometrial cancer: efficacy, safety and prognostic analysis.
CONCLUSIONS: IMRT seems to be a safe technique for the treatment of endometrial cancer with a trend towards decreased acute GI toxicities. Results of the phase 3 RTOG 1203 trial are needed to confirm these results. PMID: 31017032 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - April 24, 2019 Category: Cancer & Oncology Authors: Ta MH, Schernberg A, Giraud P, Monnier L, Darai É, Bendifallah S, Schlienger M, Touboul E, Orthuon A, Challand T, Huguet F, Rivin Del Campo E Tags: Acta Oncol Source Type: research

Tumor necrosis correlates with PD-L1 and PD-1 expression in lung adenocarcinoma.
CONCLUSION: Here we first demonstrate that the presence of necrosis correlates with higher PD-L1 expression of TC and PD-1 expression of IC in LADC. Further studies are required to determine the predictive value of this observation in LADC patients receiving immunotherapy. PMID: 31002007 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - April 19, 2019 Category: Cancer & Oncology Authors: Reiniger L, Téglási V, Pipek O, Rojkó L, Glasz T, Vágvölgyi A, Kovalszky I, Gyulai M, Lohinai Z, Rásó E, Tímár J, Döme B, Szállási Z, Moldvay J Tags: Acta Oncol Source Type: research

A systematic review of observational studies of trifluridine/tipiracil (TAS-102) for metastatic colorectal cancer.
CONCLUSION: This systematic review and a meta-analysis indicates that in real life settings, the survival benefit of FTD/TPI monotherapy in patients with therapy refractory mCRC reflects the outcomes in RECOURSE but is inferior to outcomes in the two Asian efficacy trials. What is already known TAS 102 (Lonsurf) is an oral fixed dose combination of trifluridine (FTD) and tipiracil (TPI) indicated as salvage-line treatment in patients with therapy refractory metastatic colorectal cancer (mCRC). A Japanese phase II trial and two phase III trials, RECOURSE and TERRA, demonstrated that FTD/TPI prolonged overall survival. What ...
Source: Acta Oncologica - April 19, 2019 Category: Cancer & Oncology Authors: Andersen SE, Andersen IB, Jensen BV, Pfeiffer P, Ota T, Larsen JS Tags: Acta Oncol Source Type: research

Increasing use of immunotherapy and prolonged survival among younger patients with primary CNS lymphoma: a population-based study.
CONCLUSION: In conclusion, we show that the use of poly-chemotherapy and immunotherapy has disseminated to community practice to a fair extent and survival has increased over time at least in younger patients. Annually increasing conditional survival rates provide clinicians with an adequate and encouraging prognostic measure. PMID: 30994047 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - April 17, 2019 Category: Cancer & Oncology Authors: Neuhauser M, Roetzer T, Oberndorfer S, Kitzwoegerer M, Payer F, Unterluggauer JJ, Haybaeck J, Stockhammer G, Iglseder S, Moser P, Thomé C, Stultschnig M, Wuertz F, Brandner-Kokalj T, Weis S, Bandke D, Pichler J, Hutterer M, Krenosz KJ, Boehm A, Mayrbaeur Tags: Acta Oncol Source Type: research

Automatic stratification of prostate tumour aggressiveness using multiparametric MRI: a horizontal comparison of texture features.
CONCLUSIONS: Incorporating T2w TFs significantly improved model performance for classifying prostate tumour aggressiveness. This result, however, requires further validation in a larger patient cohort. PMID: 30994052 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - April 17, 2019 Category: Cancer & Oncology Authors: Sun Y, Reynolds HM, Wraith D, Williams S, Finnegan ME, Mitchell C, Murphy D, Haworth A Tags: Acta Oncol Source Type: research

Incidence trends of adult malignant brain tumors in Finland, 1990-2016.
CONCLUSIONS: No increasing incidence trend was observed for malignant gliomas overall. An increasing incidence trend of malignant gliomas was found in the oldest age group during 1990-2006. PMID: 30985227 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - April 15, 2019 Category: Cancer & Oncology Authors: Natukka T, Raitanen J, Haapasalo H, Auvinen A Tags: Acta Oncol Source Type: research