Have the recent advancements in cancer therapy and survival benefitted patients of all age groups across the Nordic countries? NORDCAN survival analyses 2002-2021
Acta Oncol. 2024 Apr 10;63:179-191. doi: 10.2340/1651-226X.2024.35094.ABSTRACTBACKGROUND: Since the early 2000s, overall and site-specific cancer survival have improved substantially in the Nordic countries. We evaluated whether the improvements have been similar across countries, major cancer types, and age groups.MATERIAL AND METHODS: Using population-based data from the five Nordic cancer registries recorded in the NORDCAN database, we included a cohort of 1,525,854 men and 1,378,470 women diagnosed with cancer (except non-melanoma skin cancer) during 2002-2021, and followed for death until 2021. We estimated 5-year rel...
Source: Acta Oncologica - April 10, 2024 Category: Cancer & Oncology Authors: Anna L V Johansson Simon M K ønig Siri Lar ønningen Gerda Engholm Niels Kroman Karri Sepp ä Nea Malila Bjarni Á Steig Eva Maria Gudmundsd óttir El ínborg J Ólafsdóttir Frida E Lundberg Therese M-L Andersson Paul C Lambert Mats Lambe David Petterss Source Type: research
Reducing renal function assessment prior to platinum-based chemotherapy: a real-world evaluation
Acta Oncol. 2024 Apr 10;63:169-174. doi: 10.2340/1651-226X.2024.23960.ABSTRACTBACKGROUND: Platinum-based chemotherapy, a widely used backbone of systemic cytotoxic anticancer treatment, is associated with nephrotoxicity. Currently, renal function is generally assessed prior to each administration of cisplatin or carboplatin, but there is no guideline regarding the frequency of renal function determination.OBJECTIVE: The primary objective was to determine the median time to a clinically relevant dosage adjustment (>10%) due to change in renal function in patients treated with cisplatin and carboplatin. Secondly, variable...
Source: Acta Oncologica - April 10, 2024 Category: Cancer & Oncology Authors: Suzanne Van der Gaag Mariette Labots Eleonora L Swart Mirjam Crul Source Type: research
Is the risk of ischemic heart disease in women after radiotherapy for breast cancer nowadays still (linearly) associated with the mean heart dose?
Acta Oncol. 2024 Apr 10;63:175-178. doi: 10.2340/1651-226X.2024.34751.NO ABSTRACTPMID:38597665 | DOI:10.2340/1651-226X.2024.34751 (Source: Acta Oncologica)
Source: Acta Oncologica - April 10, 2024 Category: Cancer & Oncology Authors: Henk Struikmans Anna Petoukhova Joop H M Schreur Mirjam E Mast Philip M Poortmans Source Type: research
Have the recent advancements in cancer therapy and survival benefitted patients of all age groups across the Nordic countries? NORDCAN survival analyses 2002-2021
Acta Oncol. 2024 Apr 10;63:179-191. doi: 10.2340/1651-226X.2024.35094.ABSTRACTBACKGROUND: Since the early 2000s, overall and site-specific cancer survival have improved substantially in the Nordic countries. We evaluated whether the improvements have been similar across countries, major cancer types, and age groups.MATERIAL AND METHODS: Using population-based data from the five Nordic cancer registries recorded in the NORDCAN database, we included a cohort of 1,525,854 men and 1,378,470 women diagnosed with cancer (except non-melanoma skin cancer) during 2002-2021, and followed for death until 2021. We estimated 5-year rel...
Source: Acta Oncologica - April 10, 2024 Category: Cancer & Oncology Authors: Anna L V Johansson Simon M K ønig Siri Lar ønningen Gerda Engholm Niels Kroman Karri Sepp ä Nea Malila Bjarni Á Steig Eva Maria Gudmundsd óttir El ínborg J Ólafsdóttir Frida E Lundberg Therese M-L Andersson Paul C Lambert Mats Lambe David Petterss Source Type: research
Cardiovascular events among patients with prostate cancer treated with abiraterone and enzalutamide
This study provides real-world evidence of the cardiovascular risk of AA and ENZ that may not appear in clinical trial settings. Adjusting for age, baseline comorbidities, and SES, the likelihood of a cardiovascular event did not differ between treatment groups.PMID:38591349 | DOI:10.2340/1651-226X.2024.20337 (Source: Acta Oncologica)
Source: Acta Oncologica - April 9, 2024 Category: Cancer & Oncology Authors: Onur Baser Gabriela Samayoa Archana Dwivedi Sara AlSaleh Burhan Cigdem Erdi Kizilkaya Source Type: research
Area-based disparities in non-small-cell lung cancer survival
This study aimed at investigating the influence of residential area on NSCLC survival.METHODS: This population-based study utilized hospital records to identify NSCLC patients who underwent their initial treatment at Vaasa Central Hospital between January 1, 2016, and December 31, 2020. Patients were categorized based on their postal codes into urban areas (≤50 km from the hospital) and rural areas (>50 km from the hospital). Survival rates between these two groups were compared using Cox regression analysis.RESULTS: A total of 321 patients were included in the study. Patients residing in rural areas (n = 104) exhibit...
Source: Acta Oncologica - April 9, 2024 Category: Cancer & Oncology Authors: Nelly-Maria Paakkola Antti Jekunen Eero Sihvo Mikael Johansson Heidi Anders én Source Type: research
Excess weight, weight gain, and prostate cancer risk and prognosis: the PROCA-life study
Acta Oncol. 2024 Apr 9;63:154-163. doi: 10.2340/1651-226X.2024.32953.ABSTRACTBACKGROUND: Studies of excess weight and weight changes throughout adult life for prostate cancer (PCa) risk and prognosis have shown inconsistent results.METHODS: In a population-based cohort, the Prostate Cancer Study throughout life (PROCA-life), 16,960 healthy men from the prospective cohort Tromsø Study (1994-2016) were included. Body mass index (BMI) and weight were measured at all four attendings, and weight change was calculated as the difference between the first and last of either Tromsø4, Tromsø5 or Tromsø6. Overall, 904 men develop...
Source: Acta Oncologica - April 9, 2024 Category: Cancer & Oncology Authors: Martin St øyten Tore Knutsen Einar Stikbakke Ingvild Agledahl Tom Wilsgaard Anne Elise Eggen Elin Richardsen Edward Giovannucci Inger Thune Hege S Haugnes Source Type: research
Impact of the COVID-19 pandemic on lymphoma incidence and short-term survival - a Swedish Lymphoma Register Study
Acta Oncol. 2024 Apr 9;63:164-168. doi: 10.2340/1651-226X.2024.35238.ABSTRACTBACKGROUND & PURPOSE: The COVID-19 pandemic posed a large challenge for healthcare systems across the world. Comprehensive data on the impact of the COVID-19 pandemic on incidence and mortality in lymphoma are lacking.PATIENTS/METHODS: Using data from the Swedish lymphoma register, we compare incidence and 1-year survival of lymphoma patients in Sweden before (2017-2019) and during the pandemic (2020 and 2021).RESULTS: Fewer patients were diagnosed with lymphomas during March-June 2020, but the annual incidence rates for 2020 and 2021 were similar...
Source: Acta Oncologica - April 9, 2024 Category: Cancer & Oncology Authors: Sara Ekberg Daniel Molin Simon Pahnke Fanny Bergstr öm Elsa Br ånvall Karin E Smedby Tove W ästerlid Source Type: research
Cardiovascular events among patients with prostate cancer treated with abiraterone and enzalutamide
This study provides real-world evidence of the cardiovascular risk of AA and ENZ that may not appear in clinical trial settings. Adjusting for age, baseline comorbidities, and SES, the likelihood of a cardiovascular event did not differ between treatment groups.PMID:38591349 | DOI:10.2340/1651-226X.2024.20337 (Source: Acta Oncologica)
Source: Acta Oncologica - April 9, 2024 Category: Cancer & Oncology Authors: Onur Baser Gabriela Samayoa Archana Dwivedi Sara AlSaleh Burhan Cigdem Erdi Kizilkaya Source Type: research
Area-based disparities in non-small-cell lung cancer survival
This study aimed at investigating the influence of residential area on NSCLC survival.METHODS: This population-based study utilized hospital records to identify NSCLC patients who underwent their initial treatment at Vaasa Central Hospital between January 1, 2016, and December 31, 2020. Patients were categorized based on their postal codes into urban areas (≤50 km from the hospital) and rural areas (>50 km from the hospital). Survival rates between these two groups were compared using Cox regression analysis.RESULTS: A total of 321 patients were included in the study. Patients residing in rural areas (n = 104) exhibit...
Source: Acta Oncologica - April 9, 2024 Category: Cancer & Oncology Authors: Nelly-Maria Paakkola Antti Jekunen Eero Sihvo Mikael Johansson Heidi Anders én Source Type: research
Excess weight, weight gain, and prostate cancer risk and prognosis: the PROCA-life study
Acta Oncol. 2024 Apr 9;63:154-163. doi: 10.2340/1651-226X.2024.32953.ABSTRACTBACKGROUND: Studies of excess weight and weight changes throughout adult life for prostate cancer (PCa) risk and prognosis have shown inconsistent results.METHODS: In a population-based cohort, the Prostate Cancer Study throughout life (PROCA-life), 16,960 healthy men from the prospective cohort Tromsø Study (1994-2016) were included. Body mass index (BMI) and weight were measured at all four attendings, and weight change was calculated as the difference between the first and last of either Tromsø4, Tromsø5 or Tromsø6. Overall, 904 men develop...
Source: Acta Oncologica - April 9, 2024 Category: Cancer & Oncology Authors: Martin St øyten Tore Knutsen Einar Stikbakke Ingvild Agledahl Tom Wilsgaard Anne Elise Eggen Elin Richardsen Edward Giovannucci Inger Thune Hege S Haugnes Source Type: research
Impact of the COVID-19 pandemic on lymphoma incidence and short-term survival - a Swedish Lymphoma Register Study
Acta Oncol. 2024 Apr 9;63:164-168. doi: 10.2340/1651-226X.2024.35238.ABSTRACTBACKGROUND & PURPOSE: The COVID-19 pandemic posed a large challenge for healthcare systems across the world. Comprehensive data on the impact of the COVID-19 pandemic on incidence and mortality in lymphoma are lacking.PATIENTS/METHODS: Using data from the Swedish lymphoma register, we compare incidence and 1-year survival of lymphoma patients in Sweden before (2017-2019) and during the pandemic (2020 and 2021).RESULTS: Fewer patients were diagnosed with lymphomas during March-June 2020, but the annual incidence rates for 2020 and 2021 were similar...
Source: Acta Oncologica - April 9, 2024 Category: Cancer & Oncology Authors: Sara Ekberg Daniel Molin Simon Pahnke Fanny Bergstr öm Elsa Br ånvall Karin E Smedby Tove W ästerlid Source Type: research
Reduction of elective lymph node volume in radiotherapy of early anal squamous cell cancer: a comparative study between two Swedish university hospitals
This study included consecutive patients with early ASCC (T1-2N0M0) treated between 2010 and 2017 at both sites (SU n = 70; UU n = 46). Data were retrieved from medical records and RT charts.RESULTS: At SU, the external iliac and presacral LN stations were included in elective LN irradiation in 96.8% (n = 60) and 95.2% (n = 59) patients compared to 2.4% (n = 1) and 29.3% (n = 12) at UU. The mean elective LN volume was 2,313 cc (interquartile range [IQR] 1,951-2,627) in the SU cohort compared to 1,317 cc (IQR 1,192-1,528) in the UU cohort, p < 0.0001. No case of regional LN recurrence was seen in either cohort. Disease s...
Source: Acta Oncologica - April 8, 2024 Category: Cancer & Oncology Authors: Sofia Heyman Mats Perman Calin Radu Source Type: research
Hormone receptor mRNA and protein levels as predictors of premenopausal tamoxifen benefit
Acta Oncol. 2024 Apr 8;63:125-136. doi: 10.2340/1651-226X.2024.19655.ABSTRACTBACKGROUND AND PURPOSE: Tamoxifen remains an important adjuvant treatment in premenopausal patients with hormone receptor-positive breast cancer. Thus, determination of hormone receptors is important. Here, we compare cytosol-based methods, immunohistochemistry (IHC), and gene expression (GEX) analysis for determining hormone receptor status in premenopausal breast cancer patients from a randomised tamoxifen trial, to evaluate their performance in identifying patients that benefit from tamoxifen.PATIENTS AND METHODS: Premenopausal patients (n=564)...
Source: Acta Oncologica - April 8, 2024 Category: Cancer & Oncology Authors: Terese Engstr öm Maria Ekholm M årten Fernö Christine Lundgren Bo Nordenskj öld Olle St ål P är-Ola Bendahl Julia Tutzauer Lisa Ryd én Source Type: research
Incidence of vestibular schwannoma in Finland, 1990-2017
CONCLUSION: In contrast to the increasing incidence reported in some studies, we found a decreasing trend in VS incidence for both sexes in Finland.PMID:38578202 | DOI:10.2340/1651-226X.2024.20352 (Source: Acta Oncologica)
Source: Acta Oncologica - April 5, 2024 Category: Cancer & Oncology Authors: Aino Iivanainen Jani Raitanen Anssi Auvinen Source Type: research
