Choosing the right strategy based on individualized treatment effect predictions: combination versus sequential chemotherapy in patients with metastatic colorectal cancer.
CONCLUSIONS: We successfully developed individualized prediction models including prognostic characteristics derived from randomized trials to estimate treatment effects in mCRC patients. In times where the heterogeneity of CRC becomes increasingly evident, such tools are an important step towards personalized treatment. PMID: 30657353 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 18, 2019 Category: Cancer & Oncology Authors: Kwakman JJM, van Kruijsdijk RCM, Elias SG, Seymour MT, Meade AM, Visseren FLJ, Punt CJA, Koopman M Tags: Acta Oncol Source Type: research

Validation of a normal tissue complication probability model for late unfavourable aesthetic outcome after breast-conserving therapy.
Abstract PURPOSE: To validate a normal tissue complication probability (NTCP) model for late unfavourable aesthetic outcome (AO) after breast-conserving therapy. MATERIALS/METHODS: The BCCT.core software evaluated the AO using standardized photographs of patients treated at the University Hospitals Leuven between April 2015 and April 2016. Dose maps in 2 Gy equivalents were calculated assuming α/β = 3.6 Gy. The discriminating ability of the model was described by the AUC of the receiver operating characteristic curve. A 95% confidence interval (CI) of AUC was calculated ...
Source: Acta Oncologica - January 14, 2019 Category: Cancer & Oncology Authors: Kindts I, Defraene G, Petillion S, Janssen H, Van Limbergen E, Depuydt T, Weltens C Tags: Acta Oncol Source Type: research

Long-term neuropathy and quality of life in colorectal cancer patients treated with oxaliplatin containing adjuvant chemotherapy.
rlund P Abstract BACKGROUND: Oxaliplatin, combined with capecitabine (CAPOX) or infused 5-fluorouracil (FOLFOX), is standard of care in the adjuvant treatment of colorectal cancer (CRC). Prospective data on prevalence of oxaliplatin induced acute and long-term neuropathy in a real-life patient population and its effects on quality of life (QOL) and survival is limited, and scarce in CAPOX versus FOLFOX treated, especially in a subarctic climate. METHODS: One hundred forty-four adjuvant CRC patients (all 72 CAPOX cases and 72 matched FOLFOX controls) were analyzed regarding oxaliplatin induced sensory neuropat...
Source: Acta Oncologica - January 14, 2019 Category: Cancer & Oncology Authors: Soveri LM, Lamminmäki A, Hänninen UA, Karhunen M, Bono P, Osterlund P Tags: Acta Oncol Source Type: research

The prognostic role of inflammation-scores on overall survival in lung cancer patients.
CONCLUSION: In this cohort of lung cancer patients, we demonstrate that inflammation-scores are prognostic markers of inferior survival. Furthermore, we demonstrate that the optimized inflammation-scores CNG and ACBS lead to better patient-allocation independently of the clinicopathological characteristics and comorbidity. PMID: 30632850 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 11, 2019 Category: Cancer & Oncology Authors: Sandfeld-Paulsen B, Meldgaard P, Sorensen BS, Safwat A, Aggerholm-Pedersen N Tags: Acta Oncol Source Type: research

Improving dosimetric outcome for hippocampus and cochlea sparing whole brain radiotherapy using spot-scanning proton arc therapy.
Abstract This feasibility study shows that Spot-scanning Proton Arc therapy (SPArc) is able to significantly reduce the dose to the hippocampus and cochlea compared to both Volumetric Modulated Arc Photon Therapy (VMAT) and the robust optimized Intensity Modulated Proton Therapy (ro-IMPT) plans in whole brain radiotherapy. Furthermore, SPArc not only improves plan robustness but could potentially deliver a treatment as efficient as ro-IMPT when proton system's energy layer switch time is less than 1 s. PMID: 30632851 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 11, 2019 Category: Cancer & Oncology Authors: Ding X, Zhou J, Li X, Blas K, Liu G, Wang Y, Qin A, Chinnaiyan P, Yan D, Stevens C, Grills I, Kabolizadeh P Tags: Acta Oncol Source Type: research

Gastric cancer trends in Estonia 1995-2014 by age, subsite, morphology and stage.
CONCLUSIONS: In Estonia, the incidence of GC has declined and relative survival increased. However, special emphasis needs to be put on improving survival among men, elderly and in patients with metastatic disease. PMID: 30632855 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 11, 2019 Category: Cancer & Oncology Authors: Pärn ML, Innos K, Baburin A, Kiivet RA, Jaal J Tags: Acta Oncol Source Type: research

The potential diagnostic and prognostic role of extracellular vesicles in glioma: current status and future perspectives.
Abstract Lack of appropriate diagnostic/prognostic tools for glioblastoma (GB) is considered one of the major setbacks in the early diagnosis and treatment of this deadly brain tumor. The current gold standard for its diagnosis and staging still relies on invasive biopsy followed by histological examination as well as molecular profiling. Nevertheless, noninvasive approaches are being explored and one example is through the investigation of extracellular vesicles (EVs) in the biofluids of GB patients. EVs are known to carry molecular cargoes such as DNA, mRNA, miRNA, proteins and lipids in almost every type of bod...
Source: Acta Oncologica - January 11, 2019 Category: Cancer & Oncology Authors: Azam Z, Quillien V, Wang G, To ST Tags: Acta Oncol Source Type: research

Incidence of surgical interventions for metastatic bone disease in the extremities: a population-based cohort study.
ash;rk Petersen M Abstract BACKGROUND: The incidence of surgery due to metastatic bone disease in the extremities (MBDex) and postoperative survival remain uninvestigated in the population. The aim of the current study was: to identify (1) incidence, demographics and survival of a population-based cohort of patients having surgery for MBDex (2) rate of referrals and referral pattern to a musculoskeletal tumour centre (MTC). MATERIAL AND METHOD: A prospective study of a consecutive population-based cohort of patients having surgery for MBDex from 2014 to 2016. Patient demographics, indication for surgery, onco...
Source: Acta Oncologica - January 11, 2019 Category: Cancer & Oncology Authors: Skovlund Sørensen M, Hindsø K, Frederik Horstmann P, Troelsen A, Dalsgaard S, Fog T, Zimnicki T, Mørk Petersen M Tags: Acta Oncol Source Type: research

Chondrosarcoma in Norway 1990-2013; an epidemiological and prognostic observational study of a complete national cohort.
CONCLUSION: Rates of local recurrence, metastasis and disease specific survival follow clear patterns depending on subtype, location and grade allowing better tailoring of follow-up regimes. Malignancy grade 3 and the presence of a soft tissue component independently predict behavior for central CS of bone. PMID: 30632866 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 11, 2019 Category: Cancer & Oncology Authors: Thorkildsen J, Taksdal I, Bjerkehagen B, Haugland HK, Børge Johannesen T, Viset T, Norum OJ, Bruland Ø, Zaikova O Tags: Acta Oncol Source Type: research

Effect of 5-fluorouracil on cellular response to proton beam in esophageal cancer cell lines according to the position of spread-out Bragg peak.
CONCLUSIONS: Our data indicated that the degree of enhancement by 5-FU of the sensitivity of OE21 cells to 235-MeV proton beam irradiation did not differ significantly depending on the position of the cells on the SOBP. Furthermore, the degree of increase in the number of γH2AX foci at 24 h after proton beam irradiation with or without 5-FU exposure did not differ significantly according to the position on the SOBP. The effect of 5-FU in enhancing the effect of proton beam irradiation on cancer cells may be constant for all positions on the SOBP. PMID: 30632869 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 11, 2019 Category: Cancer & Oncology Authors: Hojo H, Dohmae T, Hotta K, Kageyama SI, Baba H, Kohno R, Motegi A, Tsuchihara K, Akimoto T Tags: Acta Oncol Source Type: research

Rationale for combination of radiation therapy and immune checkpoint blockers to improve cancer treatment.
h;y M Abstract Radiation therapy for cancer is considered to be immunosuppressive. However, the cellular response after radiation therapy may stimulate or suppress an immune response. The effect may vary with the tumor type and occasionally tumor regressions have been observed outside the irradiated volume, both in animal studies and in the clinic. A renewed interest in the role of immunity for the observed effect of radiation came with the current recognized role of immune checkpoint blockers (ICBs) for control of selected cancer types. We therefore here review preclinical studies and clinical reports on the inte...
Source: Acta Oncologica - January 11, 2019 Category: Cancer & Oncology Authors: Dahl O, Dale JE, Brydøy M Tags: Acta Oncol Source Type: research

Diagnostic spectrum and time intervals in Sweden's first diagnostic center for patients with nonspecific symptoms of cancer.
CONCLUSIONS: We demonstrated that the DC concept is feasible with a diagnosis reached in 86.2% of the patients in addition to favorable diagnostic time intervals at the DC and a high degree of patient satisfaction. PMID: 30632871 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 11, 2019 Category: Cancer & Oncology Authors: Stenman E, Palmér K, Rydén S, Sävblom C, Svensson I, Rose C, Ji J, Nilbert M, Sundquist J Tags: Acta Oncol Source Type: research

Magnetic resonance imaging (MRI) compared with computed tomography (CT) for interobserver agreement of gross tumor volume delineation in pancreatic cancer: a multi-institutional contouring study on behalf of the AIRO group for gastrointestinal cancers.
entini V, Morganti AG, Genovesi D Abstract BACKGROUND: Due to the high soft tissue resolution, magnetic resonance imaging (MRI) could improve the accuracy of pancreatic tumor delineation in radiation treatment planning. A multi-institutional study was proposed to evaluate the impact of MRI on inter-observer agreement in gross tumor volume (GTV) and duodenum delineation for pancreatic cancer compared with computer tomography (CT). MATERIAL AND METHODS: Two clinical cases of borderline resectable (Case 1) and unresectable (Case 2) pancreatic cancer were selected. In two sequential steps, diagnostic contrast-enh...
Source: Acta Oncologica - January 11, 2019 Category: Cancer & Oncology Authors: Caravatta L, Cellini F, Simoni N, Rosa C, Niespolo RM, Lupattelli M, Picardi V, Macchia G, Sainato A, Mantello G, Dionisi F, Rosetto ME, Fusco V, Navarria F, De Paoli A, Guido A, Vecchi C, Basilico R, Cianci R, Delli Pizzi A, Di Nicola M, Mattiucci GC, Va Tags: Acta Oncol Source Type: research

Pattern of endocrine treatment for epithelial ovarian cancer in the Southeast medical region of Sweden: a population-based study.
st E Abstract AIM OF THE STUDY: Endocrine treatment (ET) is an alternative as salvage therapy in epithelial ovarian cancer (EOC) but the usage in routine care is unknown. We evaluated the treatment patterns and outcome of patients receiving ET for EOC in the Southeast medical region in Sweden. METHOD: Patients were identified through the population-based Southeast Quality Registry for gynaecological cancer. Inclusion criteria were: age ≥18 years, histologically verified EOC diagnosed 2000-2013, ET for ≥4 weeks. Coverage compared with the Swedish National Cancer Registry was 100%. Data extracted from med...
Source: Acta Oncologica - January 11, 2019 Category: Cancer & Oncology Authors: Bagge E, Beiron U, Malander S, Rosenberg P, Åvall-Lundqvist E Tags: Acta Oncol Source Type: research

Supportive care needs and quality of life in patients with breast and gynecological cancer attending inpatient rehabilitation. A prospective study.
CONCLUSIONS: This is the first study to show that meeting breast and gynecological cancer patients' supportive care needs during inpatient rehabilitation resulted in improved QoL. Given the considerable proportions of patients still reporting unmet needs at the end of their stay, stronger and continuing efforts seem warranted to meet these needs and thus further increase QoL. PMID: 30632891 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 11, 2019 Category: Cancer & Oncology Authors: Faller H, Hass HG, Engehausen D, Reuss-Borst M, Wöckel A Tags: Acta Oncol Source Type: research

Cancer patients hospitalised in the last week of life risk insufficient care quality - a population-based study from the Swedish Register of Palliative Care.
CONCLUSIONS: Dying in hospital was associated with inferior end-of-life care quality among cancer patients in Sweden. PMID: 30633611 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 11, 2019 Category: Cancer & Oncology Authors: Elmstedt S, Mogensen H, Hallmans DE, Tavelin B, Lundström S, Lindskog M Tags: Acta Oncol Source Type: research

Neutrophil lymphocyte ratio is significantly associated with complete response to chemoradiation in locally advanced cervical cancer.
PMID: 30633614 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 11, 2019 Category: Cancer & Oncology Authors: Gangopadhyay A Tags: Acta Oncol Source Type: research

Treatment of the SPECC lesion.
Abstract The treatment of the Significant Polyp and Early Colorectal Cancer lesion has evolved from strategies formally based around didactic pathological diagnoses ('cancer or no cancer?') and the limited availability of certain techniques ('what can we do?') into a more advanced situation of understanding diagnostic uncertainty ('the what if scenario'), factoring patient preference & approach to risk and the availability of a wide range of techniques in both the rectum and the colon. It is now the former rather than the latter which are driving decision making and treatment strategies ('what should we do'). ...
Source: Acta Oncologica - January 11, 2019 Category: Cancer & Oncology Authors: Borley NR Tags: Acta Oncol Source Type: research

Association between oropharyngeal cancers with known HPV and p16 status and cervical intraepithelial neoplasia: a Danish population-based study.
CONCLUSION: HPV status in oropharyngeal tumors was not correlated with a history of ≥ IIC in cervical examinations. The effect on cervical dysplasia may be masked by a higher incidence of smoking among the OPSCC HPV-negative group. PMID: 30626248 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 9, 2019 Category: Cancer & Oncology Authors: Christensen JT, Grønhøj C, Zamani M, Brask J, Kjær EKR, Lajer H, von Buchwald C Tags: Acta Oncol Source Type: research

Whole-liver radiotherapy for diffuse liver metastases improves liver enzymes and related factors.
PMID: 30616443 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 7, 2019 Category: Cancer & Oncology Authors: Ito K, Osawa Y, Shimizuguchi T, Ogawa H, Nihei K, Karasawa K Tags: Acta Oncol Source Type: research

The efficacy of platinum-based chemotherapy for immune checkpoint inhibitor-resistant advanced melanoma.
PMID: 30614355 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 7, 2019 Category: Cancer & Oncology Authors: Maeda T, Yoshino K, Nagai K, Oaku S, Kato M, Hiura A, Hata H Tags: Acta Oncol Source Type: research

The role of biomarkers in endometrial cancer and hyperplasia: a literature review.
CONCLUSION: There is currently no routinely used biomarker in endometrial cancer for diagnostic or prognostic purposes. Given the establishment of new genomic classifications of endometrial cancers, the use of biomarkers to drive therapeutic approaches will be the cornerstone for individualised cancer care in the coming decades. PMID: 30614360 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 7, 2019 Category: Cancer & Oncology Authors: Hutt S, Tailor A, Ellis P, Michael A, Butler-Manuel S, Chatterjee J Tags: Acta Oncol Source Type: research

Evaluation of tumor-infiltrating lymphocytes and association with prognosis in BRCA-mutated breast cancer.
lm AV Abstract BACKGROUND: Patients with a BRCA1 or BRCA2 mutation (BRCA-mutated breast cancer) are frequently diagnosed with low differentiated and highly proliferating breast cancer characterized by high amounts of tumor-infiltrating lymphocytes (Tils). Stromal Tils (sTils) are highly prognostic in sporadic triple-negative and HER2 positive breast cancer however, their prognostic importance in BRCA-mutated breast cancers is unknown. MATERIAL AND METHODS: Formalin-fixed paraffin-embedded primary tumor tissue from 411 patients with a germline BRCA1 or BRCA2 mutation and diagnosed with early breast cancer was ...
Source: Acta Oncologica - January 7, 2019 Category: Cancer & Oncology Authors: Sønderstrup IMH, Jensen MB, Ejlertsen B, Eriksen JO, Gerdes AM, Kruse TA, Larsen MJ, Thomassen M, Laenkholm AV Tags: Acta Oncol Source Type: research

'Why us?' Causal attributions of childhood cancer survivors, survivors' parents and community comparisons - a mixed methods analysis.
CONCLUSION: Causal attributions differed between survivors/survivors' parents and community participants. Most of the parents and survivors seem to understand that there is nothing they have done to cause the cancer. Understanding survivors' and survivors' parents' causal attributions may be crucial to address misconceptions, offer access to services and to adapt current and future health behaviors. PMID: 30614350 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 6, 2019 Category: Cancer & Oncology Authors: Vetsch J, Wakefield CE, Doolan EL, Signorelli C, McGill BM, Moore L, Techakesari P, Pieters R, Patenaude AF, McCarthy M, Cohn RJ, ANZCHOG Survivorship Study Group Tags: Acta Oncol Source Type: research

Identifying breast cancer susceptibility genes - a review of the genetic background in familial breast cancer.
Abstract INTRODUCTION: Heritage is the most important risk factor for breast cancer. About 15-20% of breast cancer is familial, referring to affected women who have one or more first- or second-degree relatives with the disease. The heritable component in these families is substantial, especially in families with aggregation of breast cancer with low age at onset. Identifying breast cancer susceptibility genes: Since the discovery of the highly penetrant autosomal dominant susceptibility genes BRCA1 and BRCA2 in the 1990s, several more breast cancer genes that confer a moderate to high risk of breast cancer have b...
Source: Acta Oncologica - January 3, 2019 Category: Cancer & Oncology Authors: Wendt C, Margolin S Tags: Acta Oncol Source Type: research

Hyperthyroidism as a late effect in childhood cancer survivors - an Adult Life after Childhood Cancer in Scandinavia (ALiCCS) study.
CONCLUSION: Childhood cancer survivors are at an increased risk of hyperthyroidism, potentially resulting in non-endocrine morbidity. PMID: 30585514 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - December 26, 2018 Category: Cancer & Oncology Authors: Clausen CT, Hasle H, Holmqvist AS, Madanat-Harjuoja L, Tryggvadottir L, Wesenberg F, Bautz A, Winther JF, Licht SF Tags: Acta Oncol Source Type: research

Anti-m üllerian hormone compared with other ovarian markers after childhood cancer treatment.
Anti-müllerian hormone compared with other ovarian markers after childhood cancer treatment. Acta Oncol. 2018 Dec 18;:1-7 Authors: Nyström A, Mörse H, Nordlöf H, Wiebe K, Artman M, Øra I, Giwercman A, Henic E, Elfving M Abstract BACKGROUND: Gonadal dysfunction is one of the major late complications after cancer diagnosis and treatment. The best markers of ovarian reserve in clinical practice are antral follicle count (AFC) and ovarian volume. We aimed to study the prevalence of premature ovarian insufficiency (POI) and evaluate anti-Müllerian hormone (AMH) and other ser...
Source: Acta Oncologica - December 18, 2018 Category: Cancer & Oncology Authors: Nyström A, Mörse H, Nordlöf H, Wiebe K, Artman M, Øra I, Giwercman A, Henic E, Elfving M Tags: Acta Oncol Source Type: research

Potential benefit of MRI-guided IMRT for flank irradiation in pediatric patients with Wilms' tumor.
Abstract PURPOSE/OBJECTIVE: Flank irradiation for Wilms' tumor (WT) is currently performed at our institute using a cone-beam computed tomography-guided volumetric modulated arc (VMATCBCT) workflow. By adding real-time magnetic resonance imaging (MRI) guidance to the treatment, safety margins could be reduced. The study purpose was to quantify the potential reduction of the planning target volume (PTV) margin and its dosimetric impact when using an MRI-guided intensity modulated radiation therapy (IMRTMRI) workflow compared to the VMATCBCT workflow. MATERIAL/METHODS: 4D-CT, MRI and CBCT scans acquired during ...
Source: Acta Oncologica - December 7, 2018 Category: Cancer & Oncology Authors: Guerreiro F, Seravalli E, Janssens GO, van den Heuvel-Eibrink MM, Lagendijk JJW, Raaymakers BW Tags: Acta Oncol Source Type: research

Patient-reported complications related to colonoscopy: a prospective feasibility study of an email-based survey.
CONCLUSIONS: This study shows that email-based questionnaires give a high response rate independent of age or gender, but that the response rate declines with time after colonoscopy. Minor adverse events are underestimated, and colonoscopy could lead to sick leave in a minor subgroup of patients. PMID: 30523730 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - December 7, 2018 Category: Cancer & Oncology Authors: Steffenssen MW, Al-Najami I, Zimmermann-Nielsen E, Baatrup G Tags: Acta Oncol Source Type: research

Increased serological, cancer-associated protein biomarker levels at diagnosis of large bowel adenoma: Risk of subsequent primary malignancy?
CONCLUSION: Elevated blood-based, cancer-associated protein biomarker levels in subjects diagnosed with adenomas at large bowel endoscopy identifies subjects at increased risk of being diagnosed with subsequent primary malignancy. PMID: 30523734 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - December 7, 2018 Category: Cancer & Oncology Authors: Piper TB, Jørgensen LN, Olsen J, Nielsen KT, Davis G, Johansen JS, Jarle Christensen I, Nielsen HJ Tags: Acta Oncol Source Type: research

Breast cancer survival trends in different stages and age groups - a population-based study 1989-2013.
CONCLUSIONS: During the period 1989-2013 the relative risk of 5-year mortality decreased with 49%. Improvements were seen in all age groups but were unevenly distributed between stages and age groups pointing to the need for further improvements for younger and elderly patients. PMID: 30513223 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - December 4, 2018 Category: Cancer & Oncology Authors: Nordenskjöld AE, Fohlin H, Arnesson LG, Einbeigi Z, Holmberg E, Albertsson P, Karlsson P Tags: Acta Oncol Source Type: research

Sparing the surgical area with stereotactic body radiotherapy for combined treatment of spinal metastases: a treatment planning study.
Abstract INTRODUCTION: Decreasing the radiation dose in the surgical area is important to lower the risk of wound complications when surgery and radiotherapy are combined for the treatment of spinal metastases. The purpose of this study was to compare the radiation dose in the surgical area for spinal metastases between single fraction external beam radiotherapy (EBRT), single fraction stereotactic body radiotherapy (SBRT) and single fraction SBRT with active sparing (SBRT-AS) of the posterior surgical area. METHODS: Radiotherapy treatment plans for EBRT, SBRT and SBRT-AS of the posterior surgical area were c...
Source: Acta Oncologica - December 4, 2018 Category: Cancer & Oncology Authors: Versteeg AL, Hes J, van der Velden JM, Eppinga W, Kasperts N, Verkooijen HM, van Vulpen M, Oner FC, Seravalli E, Verlaan JJ Tags: Acta Oncol Source Type: research

Forty-five years in oncology, 25 years with Acta Oncologica.
PMID: 30489167 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - November 29, 2018 Category: Cancer & Oncology Authors: Glimelius B Tags: Acta Oncol Source Type: research

Prediction of ultrasound guided fine needle aspiration cytology results by FDG PET-CT for lymph node metastases in head and neck squamous cell carcinoma patients.
The objective of this study is to identify maximum standardized uptake (SUVmax) and short axis diameter cutoff values of lymph nodes at which FDG PET-CT can reliably predict USgFNAC results. METHODS: One hundred and seventeen patients with HNSCC were retrospectively analyzed. Patients were included when FDG PET-CT and USgFNAC were available. SUVmax measurements were performed and compared to the USgFNAC results. RESULTS: Using USgFNAC as a reference standard, the area under the curve of the receiver operating curve was 0.91. At an SUVmax cutoff value of 4.9, the accuracy of FDG PET-CT was the highest (85%). Lymph...
Source: Acta Oncologica - November 29, 2018 Category: Cancer & Oncology Authors: Peltenburg B, de Keizer B, Dankbaar JW, de Boer M, Willems SM, Philippens MEP, Terhaard CHJ, de Bree R Tags: Acta Oncol Source Type: research

Intensity-modulated proton therapy decreases dose to organs at risk in low-grade glioma patients: results of a multicentric in silico ROCOCO trial.
roost EGC Abstract BACKGROUND AND PURPOSE: Patients with low-grade glioma (LGG) have a prolonged survival expectancy due to better discriminative tumor classification and multimodal treatment. Consequently, long-term treatment toxicity gains importance. Contemporary radiotherapy techniques such as intensity-modulated radiotherapy (IMRT), volumetric modulated arc therapy (VMAT), tomotherapy (TOMO) and intensity-modulated proton therapy (IMPT) enable high-dose irradiation of the target but they differ regarding delivered dose to organs at risk (OARs). The aim of this comparative in silico study was to determine thes...
Source: Acta Oncologica - November 26, 2018 Category: Cancer & Oncology Authors: Eekers DBP, Roelofs E, Cubillos-Mesías M, Niël C, Smeenk RJ, Hoeben A, Minken AWH, Granzier M, Janssens GO, Kaanders JHAM, Lambin P, Troost EGC Tags: Acta Oncol Source Type: research

Evaluation of the Swedish Colorectal Cancer Registry: an overview of completeness, timeliness, comparability and validity.
CONCLUSION: The SCRCR can be considered a reliable registry useful for quality assurance and research. Standardization and improvements in journal documentation are needed to improve future evaluation of the source documents. PMID: 30477372 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - November 26, 2018 Category: Cancer & Oncology Authors: Moberger P, Sköldberg F, Birgisson H Tags: Acta Oncol Source Type: research

Complete polypectomy and early detection and management of residual disease to reduce the risk of interval colorectal cancers.
This article reviews current adenoma detection methods in use and the management of residual disease. PMID: 30457019 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - November 20, 2018 Category: Cancer & Oncology Authors: O'Morain N, McNamara D Tags: Acta Oncol Source Type: research

Multi-drug resistance protein 2 (MRP2) expression, adjuvant tamoxifen therapy, and risk of breast cancer recurrence: a Danish population-based nested case-control study.
CONCLUSIONS: MRP2 expression is neither a predictive marker of tamoxifen effectiveness nor a prognostic marker in breast cancer. PMID: 30458661 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - November 20, 2018 Category: Cancer & Oncology Authors: Hjorth CF, Nielsen AS, Sørensen HT, Lash TL, Damkier P, Hamilton-Dutoit S, Cronin-Fenton D Tags: Acta Oncol Source Type: research

Prediction of early mortality following stereotactic body radiotherapy for peripheral early-stage lung cancer.
Abstract BACKGROUND/PURPOSE: To investigate prognostic factors for death within 6 months of stereotactic body radiotherapy (SBRT) for patients with peripheral early-stage non-small cell lung cancer (NSCLC). MATERIALS AND METHODS: This analysis included 586 NSCLC patients with peripheral tumors treated with SBRT. Potential patient and tumor prognostic factors, including the Charlson Comorbidity Index (CCI) and Cumulative Illness Rating Scale (CIRS), were analyzed by logistic regression analysis for association with early mortality (death
Source: Acta Oncologica - November 19, 2018 Category: Cancer & Oncology Authors: Baker S, Sharma A, Peric R, Heemsbergen WD, Jan Nuyttens J Tags: Acta Oncol Source Type: research

The UK significant polyp and early colorectal cancer (SPECC) program.
PMID: 30451572 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - November 19, 2018 Category: Cancer & Oncology Authors: Moran BJ Tags: Acta Oncol Source Type: research

MRI-based tumor inter-fraction motion statistics for rectal cancer boost radiotherapy.
CONCLUSION: GTV inter-fraction motion, on a week-to-week and day-to-day timescale, can be accounted for using motion statistics presented in this study. PMID: 30444161 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - November 16, 2018 Category: Cancer & Oncology Authors: Kleijnen JJE, van Asselen B, Van den Begin R, Intven M, Burbach JPM, Reerink O, Philippens MEP, de Ridder M, Lagendijk JJW, Raaymakers BW Tags: Acta Oncol Source Type: research

Positive sentinel node in luminal A-like breast cancer patients - implications for adjuvant chemotherapy?
CONCLUSIONS: One sixth of patients with SN positive luminal A-like tumors risk undertreatment. The SN ratio may aid in identifying many of these patients. PMID: 30407093 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - November 8, 2018 Category: Cancer & Oncology Authors: Stenmark Tullberg A, Lundstedt D, Olofsson Bagge R, Karlsson P Tags: Acta Oncol Source Type: research

Advanced adenomas and early colorectal cancers - SATC center (SATCC). A Danish initiative for the standardization and improvement of treatment of early, significant colorectal neoplasms.
PMID: 30398078 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - November 6, 2018 Category: Cancer & Oncology Authors: Baatrup G, Buch N Tags: Acta Oncol Source Type: research

Comparison of the automatic segmentation of multiple organs at risk in CT images of lung cancer between deep convolutional neural network-based and atlas-based techniques.
In this study, a deep convolutional neural network (CNN)-based automatic segmentation technique was applied to multiple organs at risk (OARs) depicted in computed tomography (CT) images of lung cancer patients, and the results were compared with those generated through atlas-based automatic segmentation. MATERIALS AND METHODS: An encoder-decoder U-Net neural network was produced. The trained deep CNN performed the automatic segmentation of CT images for 36 cases of lung cancer. The Dice similarity coefficient (DSC), the mean surface distance (MSD) and the 95% Hausdorff distance (95% HD) were calculated, with manual se...
Source: Acta Oncologica - November 6, 2018 Category: Cancer & Oncology Authors: Zhu J, Zhang J, Qiu B, Liu Y, Liu X, Chen L Tags: Acta Oncol Source Type: research

Do we make progress in elderly patients with metastatic colorectal cancer?
PMID: 30384805 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - November 1, 2018 Category: Cancer & Oncology Authors: Glimelius B, Pfeiffer P Tags: Acta Oncol Source Type: research

The impact of training and professional collaboration on the interobserver variation of lung cancer delineations: a multi-institutional study.
Abstract BACKGROUND: To assess the impact of training and interprofessional collaboration on the interobserver variation in the delineation of the lung gross tumor volume (GTVp) and lymph node (GTVln). MATERIAL AND METHODS: Eight target volume delineations courses were organized between 2008 and 2013. Specialists and trainees in radiation oncology were asked to delineate the GTVp and GTVln on four representative CT images of a patient diagnosed with lung cancer individually prior each course (baseline), together as group (interprofessional collaboration) and post-training. The mean delineated volume and local...
Source: Acta Oncologica - October 30, 2018 Category: Cancer & Oncology Authors: Mercieca S, Belderbos JSA, van Baardwijk A, Delorme S, van Herk M Tags: Acta Oncol Source Type: research

Anti-androgen monotherapy versus gonadotropin-releasing hormone agonists in men with advanced, non-metastatic prostate cancer: a register-based, observational study.
CONCLUSION: Our results indicate that the use of AA as primary hormonal therapy in men with high-risk non-metastatic PCa does not increase PCa-specific mortality compared to GnRH. Using AA instead of GnRH agonists may result in shorter time on/exposure to GnRH-treatment, which may reduce the risk of adverse events associated with this treatment. PMID: 30375907 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - October 30, 2018 Category: Cancer & Oncology Authors: Thomsen FB, Bosco C, Garmo H, Adolfsson J, Hammar N, Stattin P, Van Hemelrijck M Tags: Acta Oncol Source Type: research

Treatment of advanced HR+/HER2- breast cancer with new targeted agents in combination with endocrine therapy: a review of efficacy and tolerability based on available randomized trials on everolimus, ribociclib, palbociclib and abemaciclib.
DISCUSSION: The new targeted agents are all associated with an improvement of the PFS with an acceptable tolerability, and they should be offered to women with advanced HR+/HER2- breast cancer both as first-line therapy as well as among patients previously treated in metastatic regimens. However, further data regarding the impact on overall survival are required to evaluate the full benefit for patients. Price and differences in AEs could become substantial arguments for the choice of therapy for the individual patient. PMID: 30375908 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - October 30, 2018 Category: Cancer & Oncology Authors: Bøttcher TM, Cold S, Jensen AB Tags: Acta Oncol Source Type: research

Malignant pleural mesothelioma in Finland: regional and gender variation.
CONCLUSIONS: MPM is a disease with a poor prognosis, although chemotherapy appears to improve survival time. Significant gender and regional variation exists among patients, with notable differences in diagnostic and treatment practices. Long-term outcomes with pemetrexed remain indeterminate. IMPACT: Emphasize centralized consult services for the diagnosis, treatment and support that patients receive for MPM, facilitating equal outcomes and compensation. PMID: 30375909 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - October 30, 2018 Category: Cancer & Oncology Authors: Laaksonen S, Ilonen I, Kuosma E, Sutinen E, Wolff H, Vehmas T, Husgafvel-Pursiainen K, Salo JA, Koli K, Räsänen J, Myllärniemi M Tags: Acta Oncol Source Type: research

Age-dependent differences in first-line chemotherapy in patients with metastatic colorectal cancer: the DISCO study.
CONCLUSIONS: In the DISCO study, older patients with mCRC received less aggressive first-line chemotherapy. Yet, they experienced more toxicity. Younger and older patients had similar CRC mortality. Shorter PFS and higher CRC mortality were observed in patients with poor PS. PMID: 30375911 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - October 30, 2018 Category: Cancer & Oncology Authors: Lund CM, Vistisen KK, Dehlendorff C, Rønholt F, Johansen JS, Nielsen DL Tags: Acta Oncol Source Type: research