Reduction of elective lymph node volume in radiotherapy of early anal squamous cell cancer: a comparative study between two Swedish university hospitals
This study included consecutive patients with early ASCC (T1-2N0M0) treated between 2010 and 2017 at both sites (SU n = 70; UU n = 46). Data were retrieved from medical records and RT charts.RESULTS: At SU, the external iliac and presacral LN stations were included in elective LN irradiation in 96.8% (n = 60) and 95.2% (n = 59) patients compared to 2.4% (n = 1) and 29.3% (n = 12) at UU. The mean elective LN volume was 2,313 cc (interquartile range [IQR] 1,951-2,627) in the SU cohort compared to 1,317 cc (IQR 1,192-1,528) in the UU cohort, p < 0.0001. No case of regional LN recurrence was seen in either cohort. Disease s...
Source: Acta Oncologica - April 8, 2024 Category: Cancer & Oncology Authors: Sofia Heyman Mats Perman Calin Radu Source Type: research
Hormone receptor mRNA and protein levels as predictors of premenopausal tamoxifen benefit
Acta Oncol. 2024 Apr 8;63:125-136. doi: 10.2340/1651-226X.2024.19655.ABSTRACTBACKGROUND AND PURPOSE: Tamoxifen remains an important adjuvant treatment in premenopausal patients with hormone receptor-positive breast cancer. Thus, determination of hormone receptors is important. Here, we compare cytosol-based methods, immunohistochemistry (IHC), and gene expression (GEX) analysis for determining hormone receptor status in premenopausal breast cancer patients from a randomised tamoxifen trial, to evaluate their performance in identifying patients that benefit from tamoxifen.PATIENTS AND METHODS: Premenopausal patients (n=564)...
Source: Acta Oncologica - April 8, 2024 Category: Cancer & Oncology Authors: Terese Engstr öm Maria Ekholm M årten Fernö Christine Lundgren Bo Nordenskj öld Olle St ål P är-Ola Bendahl Julia Tutzauer Lisa Ryd én Source Type: research
Incidence of vestibular schwannoma in Finland, 1990-2017
CONCLUSION: In contrast to the increasing incidence reported in some studies, we found a decreasing trend in VS incidence for both sexes in Finland.PMID:38578202 | DOI:10.2340/1651-226X.2024.20352 (Source: Acta Oncologica)
Source: Acta Oncologica - April 5, 2024 Category: Cancer & Oncology Authors: Aino Iivanainen Jani Raitanen Anssi Auvinen Source Type: research
CD3+ and CD8+ T cell-based immune cell score as a prognostic factor in clear-cell renal cell carcinoma
This study aims to assess the prognostic role of immune cell score in ccRCC.MATERIAL AND METHODS: All patients with ccRCC undergoing surgery between 2007 and 2020 in Central Finland Central Hospital were retrospectively identified. CD3+ and CD8+ cell densities were calculated from tissue samples to determine the immune cell score using Immunoscore® principles. Receiver-operating characteristic analysis, Kaplan-Meier survival curve, and Cox regression were used to evaluate the association between immune cell score and survival.RESULTS: A total of 203 patients (mean age 66.5 years) were identified. The median follow-up time...
Source: Acta Oncologica - April 5, 2024 Category: Cancer & Oncology Authors: Jonne Åkerla Olli Helminen Juha P V äyrynen Anne Parkkinen Hilma J ärvenpää Jan B öhm Maarit Ahtiainen Heikki Seikkula Source Type: research
Incidence of vestibular schwannoma in Finland, 1990-2017
CONCLUSION: In contrast to the increasing incidence reported in some studies, we found a decreasing trend in VS incidence for both sexes in Finland.PMID:38578202 | DOI:10.2340/1651-226X.2024.20352 (Source: Acta Oncologica)
Source: Acta Oncologica - April 5, 2024 Category: Cancer & Oncology Authors: Aino Iivanainen Jani Raitanen Anssi Auvinen Source Type: research
CD3+ and CD8+ T cell-based immune cell score as a prognostic factor in clear-cell renal cell carcinoma
This study aims to assess the prognostic role of immune cell score in ccRCC.MATERIAL AND METHODS: All patients with ccRCC undergoing surgery between 2007 and 2020 in Central Finland Central Hospital were retrospectively identified. CD3+ and CD8+ cell densities were calculated from tissue samples to determine the immune cell score using Immunoscore® principles. Receiver-operating characteristic analysis, Kaplan-Meier survival curve, and Cox regression were used to evaluate the association between immune cell score and survival.RESULTS: A total of 203 patients (mean age 66.5 years) were identified. The median follow-up time...
Source: Acta Oncologica - April 5, 2024 Category: Cancer & Oncology Authors: Jonne Åkerla Olli Helminen Juha P V äyrynen Anne Parkkinen Hilma J ärvenpää Jan B öhm Maarit Ahtiainen Heikki Seikkula Source Type: research
Incidence of vestibular schwannoma in Finland, 1990-2017
CONCLUSION: In contrast to the increasing incidence reported in some studies, we found a decreasing trend in VS incidence for both sexes in Finland.PMID:38578202 | DOI:10.2340/1651-226X.2024.20352 (Source: Acta Oncologica)
Source: Acta Oncologica - April 5, 2024 Category: Cancer & Oncology Authors: Aino Iivanainen Jani Raitanen Anssi Auvinen Source Type: research
CD3+ and CD8+ T cell-based immune cell score as a prognostic factor in clear-cell renal cell carcinoma
This study aims to assess the prognostic role of immune cell score in ccRCC.MATERIAL AND METHODS: All patients with ccRCC undergoing surgery between 2007 and 2020 in Central Finland Central Hospital were retrospectively identified. CD3+ and CD8+ cell densities were calculated from tissue samples to determine the immune cell score using Immunoscore® principles. Receiver-operating characteristic analysis, Kaplan-Meier survival curve, and Cox regression were used to evaluate the association between immune cell score and survival.RESULTS: A total of 203 patients (mean age 66.5 years) were identified. The median follow-up time...
Source: Acta Oncologica - April 5, 2024 Category: Cancer & Oncology Authors: Jonne Åkerla Olli Helminen Juha P V äyrynen Anne Parkkinen Hilma J ärvenpää Jan B öhm Maarit Ahtiainen Heikki Seikkula Source Type: research
Time trends in the use of curative treatment in men 70 years and older with nonmetastatic prostate cancer
Acta Oncol. 2024 Mar 20;63:95-104. doi: 10.2340/1651-226X.2024.26189.ABSTRACTBACKGROUND: Undertreatment of otherwise healthy men in their seventies with prostate cancer has been reported previously.MATERIAL AND METHODS: Using information in a Swedish prostate cancer research database, patterns of management and cancer-specific mortality were compared across age groups in over 70,000 men diagnosed with intermediate- or high-risk nonmetastatic prostate cancer between 2008 and 2020. Crude probabilities of death were estimated non-parametrically. Staging procedures, primary treatment, and cancer death were compared using regre...
Source: Acta Oncologica - March 20, 2024 Category: Cancer & Oncology Authors: Frida Lundberg David Robinson Ola Bratt Giuseppe Fallara Mats Lambe Anna L V Johansson Source Type: research
Time trends in the use of curative treatment in men 70 years and older with nonmetastatic prostate cancer
Acta Oncol. 2024 Mar 20;63:95-104. doi: 10.2340/1651-226X.2024.26189.ABSTRACTBACKGROUND: Undertreatment of otherwise healthy men in their seventies with prostate cancer has been reported previously.MATERIAL AND METHODS: Using information in a Swedish prostate cancer research database, patterns of management and cancer-specific mortality were compared across age groups in over 70,000 men diagnosed with intermediate- or high-risk nonmetastatic prostate cancer between 2008 and 2020. Crude probabilities of death were estimated non-parametrically. Staging procedures, primary treatment, and cancer death were compared using regre...
Source: Acta Oncologica - March 20, 2024 Category: Cancer & Oncology Authors: Frida Lundberg David Robinson Ola Bratt Giuseppe Fallara Mats Lambe Anna L V Johansson Source Type: research
Time trends in the use of curative treatment in men 70 years and older with nonmetastatic prostate cancer
Acta Oncol. 2024 Mar 20;63:95-104. doi: 10.2340/1651-226X.2024.26189.ABSTRACTBACKGROUND: Undertreatment of otherwise healthy men in their seventies with prostate cancer has been reported previously.MATERIAL AND METHODS: Using information in a Swedish prostate cancer research database, patterns of management and cancer-specific mortality were compared across age groups in over 70,000 men diagnosed with intermediate- or high-risk nonmetastatic prostate cancer between 2008 and 2020. Crude probabilities of death were estimated non-parametrically. Staging procedures, primary treatment, and cancer death were compared using regre...
Source: Acta Oncologica - March 20, 2024 Category: Cancer & Oncology Authors: Frida Lundberg David Robinson Ola Bratt Giuseppe Fallara Mats Lambe Anna L V Johansson Source Type: research
Time trends in the use of curative treatment in men 70 years and older with nonmetastatic prostate cancer
Acta Oncol. 2024 Mar 20;63:95-104. doi: 10.2340/1651-226X.2024.26189.ABSTRACTBACKGROUND: Undertreatment of otherwise healthy men in their seventies with prostate cancer has been reported previously.MATERIAL AND METHODS: Using information in a Swedish prostate cancer research database, patterns of management and cancer-specific mortality were compared across age groups in over 70,000 men diagnosed with intermediate- or high-risk nonmetastatic prostate cancer between 2008 and 2020. Crude probabilities of death were estimated non-parametrically. Staging procedures, primary treatment, and cancer death were compared using regre...
Source: Acta Oncologica - March 20, 2024 Category: Cancer & Oncology Authors: Frida Lundberg David Robinson Ola Bratt Giuseppe Fallara Mats Lambe Anna L V Johansson Source Type: research
Time trends in the use of curative treatment in men 70 years and older with nonmetastatic prostate cancer
Acta Oncol. 2024 Mar 20;63:95-104. doi: 10.2340/1651-226X.2024.26189.ABSTRACTBACKGROUND: Undertreatment of otherwise healthy men in their seventies with prostate cancer has been reported previously.MATERIAL AND METHODS: Using information in a Swedish prostate cancer research database, patterns of management and cancer-specific mortality were compared across age groups in over 70,000 men diagnosed with intermediate- or high-risk nonmetastatic prostate cancer between 2008 and 2020. Crude probabilities of death were estimated non-parametrically. Staging procedures, primary treatment, and cancer death were compared using regre...
Source: Acta Oncologica - March 20, 2024 Category: Cancer & Oncology Authors: Frida Lundberg David Robinson Ola Bratt Giuseppe Fallara Mats Lambe Anna L V Johansson Source Type: research
Time trends in the use of curative treatment in men 70 years and older with nonmetastatic prostate cancer
Acta Oncol. 2024 Mar 20;63:95-104. doi: 10.2340/1651-226X.2024.26189.ABSTRACTBACKGROUND: Undertreatment of otherwise healthy men in their seventies with prostate cancer has been reported previously.MATERIAL AND METHODS: Using information in a Swedish prostate cancer research database, patterns of management and cancer-specific mortality were compared across age groups in over 70,000 men diagnosed with intermediate- or high-risk nonmetastatic prostate cancer between 2008 and 2020. Crude probabilities of death were estimated non-parametrically. Staging procedures, primary treatment, and cancer death were compared using regre...
Source: Acta Oncologica - March 20, 2024 Category: Cancer & Oncology Authors: Frida Lundberg David Robinson Ola Bratt Giuseppe Fallara Mats Lambe Anna L V Johansson Source Type: research
Time trends in the use of curative treatment in men 70 years and older with nonmetastatic prostate cancer
Acta Oncol. 2024 Mar 20;63:95-104. doi: 10.2340/1651-226X.2024.26189.ABSTRACTBACKGROUND: Undertreatment of otherwise healthy men in their seventies with prostate cancer has been reported previously.MATERIAL AND METHODS: Using information in a Swedish prostate cancer research database, patterns of management and cancer-specific mortality were compared across age groups in over 70,000 men diagnosed with intermediate- or high-risk nonmetastatic prostate cancer between 2008 and 2020. Crude probabilities of death were estimated non-parametrically. Staging procedures, primary treatment, and cancer death were compared using regre...
Source: Acta Oncologica - March 20, 2024 Category: Cancer & Oncology Authors: Frida Lundberg David Robinson Ola Bratt Giuseppe Fallara Mats Lambe Anna L V Johansson Source Type: research
