The impact of a breast cancer diagnosis on health-related quality of life. A prospective comparison among middle-aged to elderly women with and without breast cancer.
Conclusions Women with breast cancer reported significantly larger HQoL declines than breast cancer-free women. Breast cancer diagnosis seems to have the greatest impact on HQoL closest to diagnosis and in women with comorbidity indicating that this group should be offered timely and appropriate follow-up care to prevent HQoL declines. PMID: 26942569 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - March 4, 2016 Category: Cancer & Oncology Authors: Karlsen RV, Frederiksen K, Larsen MB, von Heymann-Horan AB, Appel CW, Christensen J, Tjønneland A, Ross L, Johansen C, Bidstrup PE Tags: Acta Oncol Source Type: research

Dosimetric advantages of proton therapy compared with photon therapy using an adaptive strategy in cervical cancer.
In this study, the potential dosimetric advantages of IGAPT compared with photon-based image-guided adaptive RT (IGART) were investigated. Material and methods For 13 cervical cancer patients, full and empty bladder planning computed tomography (CT) images and weekly CTs were acquired. Based on both primary clinical target volumes (pCTVs) [i.e. gross tumor volume (GTV), cervix, corpus-uterus and upper part of the vagina] on planning CTs, the pretreatment observed full range primary internal target volume (pITV) was interpolated to derive pITV subranges. Given corresponding ITVs (i.e. pITVs including lymph nodes), patient-s...
Source: Acta Oncologica - March 3, 2016 Category: Cancer & Oncology Authors: van de Schoot AJ, de Boer P, Crama KF, Visser J, Stalpers LJ, Rasch CR, Bel A Tags: Acta Oncol Source Type: research

Testing the methodology for dosimetry audit of heterogeneity corrections and small MLC-shaped fields: Results of IAEA multi-center studies.
DISCUSSION: Through multi-center testing, any challenges or difficulties in the proposed audit methodology were identified, and the methodology improved. Using the experience of these studies, the participants could incorporate the auditing procedures in their national programs. PMID: 26934916 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - March 3, 2016 Category: Cancer & Oncology Authors: Izewska J, Wesolowska P, Azangwe G, Followill DS, Thwaites DI, Arib M, Stefanic A, Viegas C, Suming L, Ekendahl D, Bulski W, Georg D Tags: Acta Oncol Source Type: research

Deep inspiration breath-hold volumetric modulated arc radiotherapy decreases dose to mediastinal structures in locally advanced lung cancer.
Aznar MC PMID: 26935017 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - March 3, 2016 Category: Cancer & Oncology Authors: Persson GF, Scherman Rydhög J, Josipovic M, Maraldo MV, Nygård L, Costa J, Berthelsen AK, Specht L, Aznar MC Tags: Acta Oncol Source Type: research

Risk structures for radiation-induced trismus in head and neck cancer.
a C PMID: 26935147 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - March 3, 2016 Category: Cancer & Oncology Authors: Pauli N, Olsson C, Pettersson N, Johansson M, Haugen H, Wilderäng U, Steineck G, Finizia C Tags: Acta Oncol Source Type: research

Effect of socioeconomic position on survival after childhood cancer in Denmark.
SO Abstract Background One fifth of all deaths among children in Europe are accounted for by cancer. If this is to be reduced there is a need for studies on not only biology and treatment approaches but also on how social factors influence cure rates. We investigated how various socioeconomic characteristics were associated with survival after childhood cancer. Material and methods In a nationwide cohort of 3797 children diagnosed with cancer [hematological cancer, central nervous system (CNS) tumors, non-CNS solid tumors] before age 20 between 1990 and 2009 we identified parents and siblings and obtained individ...
Source: Acta Oncologica - March 3, 2016 Category: Cancer & Oncology Authors: Simony SB, Lund LW, Erdmann F, Andersen KK, Winther JF, Schüz J, Johansen C, Schmiegelow K, Dalton SO Tags: Acta Oncol Source Type: research

Cutaneous malignant melanoma show geographic and socioeconomic disparities in stage at diagnosis and excess mortality.
Conclusion Residential region and educational level influenced CMM stage and, thereby, excess mortality. These observations suggest that geographic as well as socioeconomic data should be considered in prevention of CMM. PMID: 26935355 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - March 3, 2016 Category: Cancer & Oncology Authors: Strömberg U, Peterson S, Holmberg E, Holmén A, Persson B, Sandberg C, Nilbert M Tags: Acta Oncol Source Type: research

Fear of cancer recurrence in prostate cancer survivors.
Conclusions Results illustrate that FCR is a significant problem in PCa survivors. Younger men and those treated with adjuvant radiotherapy are especially at risk. Those with high FCR experience worse QOL and higher symptom burden. Health care providers should pay specific attention to this problem and provide appropriate psychosocial care when needed. PMID: 26935517 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - March 3, 2016 Category: Cancer & Oncology Authors: van de Wal M, van Oort I, Schouten J, Thewes B, Gielissen M, Prins J Tags: Acta Oncol Source Type: research

Any progress in pancreatic cancer?
PMID: 26883020 [PubMed - in process] (Source: Acta Oncologica)
Source: Acta Oncologica - February 19, 2016 Category: Cancer & Oncology Authors: Glimelius B Tags: Acta Oncol Source Type: research

Outcomes of Bleomycin-based electrochemotherapy in patients with repeated loco-regional recurrences of vulvar cancer.
Conclusions Objective responses (ORs) with local control of the tumor were obtained in 80%. After a mean follow-up of 12 (3-22) months six patients (60%) were alive. The favorable outcome of this study, indicates that ECT is a reliable treatment option that may improve their functioning, thus enhancing the care provided in the palliative setting. PMID: 26882959 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - February 17, 2016 Category: Cancer & Oncology Authors: Pellegrino A, Damiani GR, Mangioni C, Strippoli D, Loverro G, Cappello A, Turoli Scd D, Corso S, Tartagni M, Pezzotta MG Tags: Acta Oncol Source Type: research

Awareness of cancer symptoms and anticipated patient interval for healthcare seeking. A comparative study of Denmark and Sweden.
Conclusion Somewhat paradoxically, the highest awareness of symptoms of cancer and the shortest anticipated patient intervals were found in Denmark, where cancer survival is lower than in Sweden. Thus, it appears that these differences in symptom awareness and anticipated patient interval do not help explain the cancer survival disparity between Denmark and Sweden. PMID: 26882008 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - February 16, 2016 Category: Cancer & Oncology Authors: Hvidberg L, Lagerlund M, Pedersen AF, Hajdarevic S, Tishelman C, Vedsted P Tags: Acta Oncol Source Type: research

Prostate cancer patients' quality of life assessments across the primary treatment trajectory: 'True' change or response shift?
Conclusion Our results suggest that changes observed in some subscales of the EORTC QLQ-C30 should not be taken at face value as they may be affected by patients' changed measurement standards. PMID: 26882096 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - February 16, 2016 Category: Cancer & Oncology Authors: Gerlich C, Schuler M, Jelitte M, Neuderth S, Flentje M, Graefen M, Krüger A, Mehnert A, Faller H Tags: Acta Oncol Source Type: research

Longitudinal biobanks-based study on the joint effects of infections, nutrition and hormones on risk of prostate cancer.
Conclusion A large follow-up study combining data from several previously investigated exposures to investigate joint effects found no evidence that exposure to two risk factors would increase the risk of prostate cancer from that expected on basis of exposure to one risk factor. If anything, the results were consistent with antagonistic interactions. PMID: 26878091 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - February 15, 2016 Category: Cancer & Oncology Authors: Lumme S, Tenkanen L, Langseth H, Gislefoss R, Hakama M, Stattin P, Hallmans G, Adlercreutz H, Saikku P, Stenman UH, Tuohimaa P, Luostarinen T, Dillner J Tags: Acta Oncol Source Type: research

Survival improvements associated with access to biological agents: Results from the South Australian (SA) metastatic colorectal cancer (mCRC) registry.
Abstract Background Randomized controlled trials evaluating biological therapy have shown improvements in survival from metastatic colorectal cancer (mCRC). Subjects in the trials represent a selected proportion of mCRC patients. We have the potential to assess the impact of biological therapy on mCRC outcomes, particularly the effect of bevacizumab, from a population-based clinical registry by comparing two time cohorts with differences in therapy accessibility. Material and methods A retrospective cohort study was performed by analyzing the South Australian (SA) mCRC registry data based on diagnosis in two time ...
Source: Acta Oncologica - February 15, 2016 Category: Cancer & Oncology Authors: Tomita Y, Karapetis CS, Ullah S, Townsend AR, Roder D, Beeke C, Roy AC, Padbury R, Price TJ Tags: Acta Oncol Source Type: research

Clinical outcome in patients treated with simultaneous integrated boost - intensity modulated radiation therapy (SIB-IMRT) with and without concurrent chemotherapy for squamous cell carcinoma of the anal canal.
Conclusions SIB-IMRT ± concurrent chemotherapy for anal cancer was effective with acceptable toxicity. PMID: 26878244 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - February 15, 2016 Category: Cancer & Oncology Authors: Tomasoa NB, Meulendijks D, Nijkamp J, Cats A, Dewit L Tags: Acta Oncol Source Type: research

An analysis of planned versus delivered airway doses during stereotactic lung radiotherapy for central tumors.
n S PMID: 26878324 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - February 15, 2016 Category: Cancer & Oncology Authors: Dahele M, van Sörnsen de Koste JR, Verbakel WF, Slotman BJ, Senan S Tags: Acta Oncol Source Type: research

Time trends in axilla management among early breast cancer patients: Persisting major variation in clinical practice across European centers.
Conclusion This study demonstrates persisting differences in important aspects of axillary management throughout the recent decade. The results highlight the need for international comparative patterns of care studies in oncology, which may help to identify areas where further studies and consensus building may be necessary. PMID: 26878397 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - February 15, 2016 Category: Cancer & Oncology Authors: Gondos A, Jansen L, Heil J, Schneeweiss A, Voogd AC, Frisell J, Fredriksson I, Johansson U, Tvedskov TF, Jensen MB, Balslev E, Hartmann-Johnsen OJ, Sant M, Baili P, Agresti R, van de Velde T, Broeks A, Nogaret JM, Bourgeois P, Moreau M, Mátrai Z, Sávolt Tags: Acta Oncol Source Type: research

Exercise intervention for the treatment of trismus in head and neck cancer - a prospective two-year follow-up study.
Conclusion A positive persistent effect of exercise intervention for trismus in HNC patients was found with regard to MIO, trismus-related symptoms and HRQL. Exercise intervention is important in long-term treatment of radiation-induced trismus in HNC patients. The trismus-specific questionnaire, GTQ, is a valuable tool for observing and evaluating trismus over time. PMID: 26878553 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - February 15, 2016 Category: Cancer & Oncology Authors: Pauli N, Svensson U, Karlsson T, Finizia C Tags: Acta Oncol Source Type: research

Metabolic liver function after stereotactic body radiation therapy for hepatocellular carcinoma.
Conclusion Despite the fact that patients received high radiation dose to the liver, there was only moderate morbidity related to the treatment. The s-albumin decreases over three months after SBRT reflecting minor to moderate hepatic toxicity. S-albumin should be observed in the follow-up of HCC patients treated with SBRT. PMID: 26878669 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - February 15, 2016 Category: Cancer & Oncology Authors: Dreher C, Høyer KI, Fode MM, Habermehl D, Combs SE, Høyer M Tags: Acta Oncol Source Type: research

HER3 expression is correlated to distally located and low-grade colon cancer.
, Edler D Abstract Background HER3 is a member of the human epidermal growth factor receptor complex (EGFR, HER2, HER3 and HER4). It has been investigated as a prognostic biomarker in colorectal cancer but is sparingly studied in colon cancer. HER3 can affect cellular proliferation, differentiation and migration in oncogenesis through ligand binding and activation of intracellular signal pathways. Recently, we found that expression of cell surface HER3 can be detected at a high extent in primary colorectal tumors, lymph node and liver metastases and that it correlated with poor prognosis. This large, explorative, ...
Source: Acta Oncologica - February 10, 2016 Category: Cancer & Oncology Authors: Lédel F, Stenstedt K, Hallström M, Ragnhammar P, Edler D Tags: Acta Oncol Source Type: research

Improved survival of colorectal cancer in Denmark during 2001-2012 - the efforts of several national initiatives.
Conclusion The Danish efforts to improve outcome of cancer have succeeded with improved outcomes in patients with colorectal cancer. PMID: 26859340 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - February 9, 2016 Category: Cancer & Oncology Authors: Iversen LH, Green A, Ingeholm P, Østerlind K, Gögenur I Tags: Acta Oncol Source Type: research

Development and validation of a prognostic model for recurrent glioblastoma patients treated with bevacizumab and irinotecan.
Abstract Background Predictive markers and prognostic models are required in order to individualize treatment of recurrent glioblastoma (GBM) patients. Here, we sought to identify clinical factors able to predict response and survival in recurrent GBM patients treated with bevacizumab (BEV) and irinotecan. Material and methods A total of 219 recurrent GBM patients treated with BEV plus irinotecan according to a previously published treatment protocol were included in the initial population. Prognostic models were generated by means of multivariate logistic and Cox regression analysis. Results In multivariate analy...
Source: Acta Oncologica - February 1, 2016 Category: Cancer & Oncology Authors: Urup T, Dahlrot RH, Grunnet K, Christensen IJ, Michaelsen SR, Toft A, Larsen VA, Broholm H, Kosteljanetz M, Hansen S, Poulsen HS, Lassen U Tags: Acta Oncol Source Type: research

Malignancies in transplanted patients: Multidisciplinary evaluation and switch to mTOR inhibitors after kidney transplantation - experiences from a prospective, clinical, observational study.
Conclusion In two thirds of the patients the immunosuppressive treatment could be changed to an mTOR inhibitor with anti-tumor effects in transplanted patients with post-transplant malignancies. The use of regional tumor registers considerably improved the identification of patients with post-transplant malignancies indicating that post-transplant malignancies might be timely underreported in transplant registers. PMID: 26824275 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 29, 2016 Category: Cancer & Oncology Authors: Hellström VC, Enström Y, von Zur-Mühlen B, Hagberg H, Laurell A, Nyberg F, Bäckman L, Opelz G, Döhler B, Holmberg L, Tufveson G, Enblad G, Lorant T Tags: Acta Oncol Source Type: research

Assessment of rehabilitation needs in colorectal cancer treatment: Results from a mixed audit and qualitative study in Denmark.
Conclusion Consensus must be reached on how to ensure more systematic, comprehensive assessments of rehabilitation needs throughout clinical cancer care. Fast-track surgery ensures systematic documentation of physical needs, but the lack of inclusion of data collected by the DT in oncological departments questions the efficacy of assessment tools and points to a need for distinguishing between surgical and oncological settings in national rehabilitation policies. PMID: 26808254 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 25, 2016 Category: Cancer & Oncology Authors: Wiedenbein L, Kristiansen M, Adamsen L, Hjort D, Hendriksen C Tags: Acta Oncol Source Type: research

Consequences of a false-positive mammography result: drug consumption before and after screening.
Conclusion(s) Drugs used to mitigate mood disorders were used more frequently by women with false-positive than by women with normal mammograms already before the screening event, while the changes from before to after screening were similar for both groups. The results point to the importance of control for potential selection in studies of screening effects. PMID: 26799406 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 22, 2016 Category: Cancer & Oncology Authors: von Euler-Chelpin M, Bæksted C, Vejborg I, Lynge E Tags: Acta Oncol Source Type: research

Impact of hydrogel spacer injections on interfraction prostate motion during prostate cancer radiotherapy.
Conclusions HS implantation does not significantly influence the interfraction prostate motion in patients treated with RT for prostate cancer. The major expected benefit of HS is a reduction of the high-dose levels to the rectal wall without influence in prostate immobilization. PMID: 26796870 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 21, 2016 Category: Cancer & Oncology Authors: Picardi C, Rouzaud M, Kountouri M, Lestrade L, Vallée JP, Caparrotti F, Dubouloz A, Miralbell R, Zilli T Tags: Acta Oncol Source Type: research

Improvements in breast cancer survival between 1995 and 2012 in Denmark: The importance of earlier diagnosis and adjuvant treatment.
Conclusion The impact of screening was by nature of limited magnitude. The modified treatment strategies implemented by the use of nationwide guidelines seemed to have a major impact on the substantial survival improvements. PMID: 26797010 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 21, 2016 Category: Cancer & Oncology Authors: Jensen MB, Ejlertsen B, Mouridsen HT, Christiansen P, Danish Breast Cancer Cooperative Group Tags: Acta Oncol Source Type: research

Trends in breast cancer in the elderly in Denmark, 1980-2012.
Conclusion Poorer survival of Danish breast cancer patients over the age of 70 years is likely to be due to inferior treatment and non-adherence to treatment guidelines. There is a need for clinical trials focusing on patients over the age of 70 years. PMID: 26781003 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 19, 2016 Category: Cancer & Oncology Authors: Jensen JD, Cold S, Nielsen MH, Jylling AM, Søe KL, Larsen LB, Ewertz M, Academy of Geriatric Cancer Research (AgeCare) Tags: Acta Oncol Source Type: research

Trends in tumors in the central nervous system in elderly in Denmark, 2008-2012.
Conclusion This study suggests that the current treatment strategies in general may have improved survival in patients with CNS tumors, but in order to improve survival further in the increasing group of elderly patients more knowledge about treatment of these patients is needed. PMID: 26781160 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 19, 2016 Category: Cancer & Oncology Authors: Dahlrot RH, Poulsen FR, Nguyen NN, Kristensen BW, Hansen S, Holm NV, Academy of Geriatric Cancer Research (AgeCare) Tags: Acta Oncol Source Type: research

Trends in cancer in the elderly population in Denmark, 1980-2012.
Conclusion An increase in elderly cancer patients is expected over the coming 20 years due to an increasing elderly population. Healthcare providers need to focus on developing specific strategies for treatment of elderly cancer patients in the future. PMID: 26781233 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 19, 2016 Category: Cancer & Oncology Authors: Ewertz M, Christensen K, Engholm G, Kejs AM, Lund L, Matzen LE, Pfeiffer P, Storm HH, Herrstedt J, Academy of Geriatric Cancer Research (AgeCare) Tags: Acta Oncol Source Type: research

Trends in prostate cancer in elderly in Denmark, 1980-2012.
Abstract Backgound The purpose of the study is to elucidate the epidemiology of elderly patients with prostate cancer in Denmark and identify the differences between younger (
Source: Acta Oncologica - January 19, 2016 Category: Cancer & Oncology Authors: Poulsen MH, Dysager L, Gerke O, Lund L, Academy of Geriatric Cancer Research (AgeCare) Tags: Acta Oncol Source Type: research

Trends in hematological cancer in the elderly in Denmark, 1980-2012.
Conclusion Improvements in diagnostics and treatment have led to increased survival and therefore prevalence of elderly patients with NHL, MM, CLL and AML during the past decades. PMID: 26783877 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 19, 2016 Category: Cancer & Oncology Authors: Ocias LF, Larsen TS, Vestergaard H, Friis LS, Abildgaard N, Frederiksen H, Academy of Geriatric Cancer Research (AgeCare) Tags: Acta Oncol Source Type: research

Trends in gynecologic cancer among elderly women in Denmark, 1980-2012.
Conclusion In gynecologic cancer both mortality rates and survival are age-dependent with a significantly shorter survival in the group of elderly. PMID: 26784001 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 19, 2016 Category: Cancer & Oncology Authors: Ør Knudsen A, Schledermann D, Nyvang GB, Mogensen O, Herrstedt J, Academy of Geriatric Cancer Research (AgeCare) Tags: Acta Oncol Source Type: research

Trends in kidney cancer among the elderly in Denmark, 1980-2012.
Conclusion A challenge in managing kidney cancer in the elderly is to establish interdisciplinary collaborations between different specialties, such as surgeons, clinical oncologists, and geriatricians to be able to deliver the best possible care in the future. PMID: 26784139 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 19, 2016 Category: Cancer & Oncology Authors: Azawi NH, Joergensen SM, Jensen NV, Clark PE, Lund L, Academy of Geriatric Cancer Research (AgeCare) Tags: Acta Oncol Source Type: research

Trends in cancer of the urinary bladder and urinary tract in elderly in Denmark, 2008-2012.
Conclusion More prospective data are needed, preferably as randomized clinical trials, for determining the influence of age on the decisions of the surgical approach as well as chemo/radiotherapy for the elderly patients with urothelial cancers compared to younger patients. PMID: 26784363 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 19, 2016 Category: Cancer & Oncology Authors: Jensen TK, Jensen NV, Jørgensen SM, Clark P, Lund L, Academy of Geriatric Cancer Research (AgeCare) Tags: Acta Oncol Source Type: research

Trends in melanoma in the elderly in Denmark, 1980-2012.
Conclusion The incidence rates for all age groups are rising. The increase was mainly caused by a rising incidence among the elderly. Mortality among Danish patients with melanoma is increasing and especially the mortality in the elderly. This important knowledge must be kept in mind when future treatment strategies are planned. PMID: 26785326 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 19, 2016 Category: Cancer & Oncology Authors: Hoejberg L, Gad D, Gyldenkerne N, Bastholt L, Academy of Geriatric Cancer Research (AgeCare) Tags: Acta Oncol Source Type: research

Coverage and accuracy of myeloproliferative and myelodysplastic neoplasms in the Finnish Cancer Registry.
Conclusions More than half of the patients found in the HILMO were entirely missing from the FCR. However, some of the diagnoses in HILMO may be preliminary and this represents the maximal number of missing cases. Cancer registers benefit from supplementary data sources, such as hospital discharges, to increase coverage and accuracy of register data on haematological malignancies. PMID: 26767306 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 15, 2016 Category: Cancer & Oncology Authors: Leinonen MK, Rantanen M, Pitkäniemi J, Malila N Tags: Acta Oncol Source Type: research

Trends in cancer of the liver, gall bladder, bile duct, and pancreas in elderly in Denmark, 1980-2012.
Conclusion As the number of persons aged 80 years or more will increase dramatically in the following years, and our results show a gap in relative survival, it is important to continue to study this population in order to improve management and outcome. PMID: 26767397 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 15, 2016 Category: Cancer & Oncology Authors: Bjerregaard JK, Mortensen MB, Pfeiffer P, Academy of Geriatric Cancer Research (AgeCare) Tags: Acta Oncol Source Type: research

Trends in lung cancer in elderly in Denmark, 1980-2012.
Conclusion The incidence of lung cancer is closely linked to the pattern of tobacco smoking with the differences between gender and age groups reflecting smoking behavior in birth cohorts. Elderly patients with lung cancer are a heterogeneous group in whom treatment should be offered according to comorbidity and a geriatric assessment. PMID: 26769559 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 15, 2016 Category: Cancer & Oncology Authors: Kristiansen C, Schytte T, Hansen KH, Holtved E, Hansen O, Academy of Geriatric Cancer Research (AgeCare) Tags: Acta Oncol Source Type: research

Trends in upper gastro-intestinal cancer among the elderly in Denmark, 1980-2012.
Conclusion There is a need for clinical trials focusing on patients over the age of 70 years with co-existing comorbidity. PMID: 26765771 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 14, 2016 Category: Cancer & Oncology Authors: Schønnemann KR, Mortensen MB, Krogh M, Holtved E, Andersen MM, Pfeiffer P, Academy of Geriatric Cancer Research (AgeCare) Tags: Acta Oncol Source Type: research

Trends in colorectal cancer in the elderly in Denmark, 1980-2012.
Conclusion The incidence of CRC is increasing, especially in older citizens, and mortality increases with older age. There is limited knowledge on how to optimize treatment in older CRC patients and future focus must be how to select and tailor the treatment for older CRC patients. PMID: 26765865 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 14, 2016 Category: Cancer & Oncology Authors: Brændegaard Winther S, Baatrup G, Pfeiffer P, Qvortrup C, Academy of Geriatric Cancer Research (AgeCare) Tags: Acta Oncol Source Type: research

Trends in cancer of the head and neck in the elderly in Denmark, 1980-2012.
Conclusion HNSCC is a rare disease in patients above 70 years accounting for only 17% of all HNSCC patients. Incidence rates increased over time, but age-specific survival rates improved, especially in younger patients. Failure rates to comply with radiation treatment, however, were low in both young and elderly patients. PMID: 26760291 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 13, 2016 Category: Cancer & Oncology Authors: Johansen J, Grau Eriksen J, Academy of Geriatric Cancer Research (AgeCare) Tags: Acta Oncol Source Type: research

Tuberculosis reactivation in a patient receiving anti-programmed death-1 (PD-1) inhibitor for relapsed Hodgkin's lymphoma.
PMID: 26754959 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 12, 2016 Category: Cancer & Oncology Authors: Lee JJ, Chan A, Tang T Tags: Acta Oncol Source Type: research

The effect of training during treatment with chemotherapy on muscle strength and endurance capacity: A systematic review.
Conclusions This review indicates that training during chemotherapy may help in preventing the decrease in muscle strength and endurance capacity. It is important to know which training intensity and duration is the most effective in training cancer patients, to provide a training program suitable for every cancer patient. Training should be based on good research and should be implemented into international guidelines and daily practice. More research is needed. PMID: 26755191 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 12, 2016 Category: Cancer & Oncology Authors: Van Moll CC, Schep G, Vreugdenhil A, Savelberg HH, Husson O Tags: Acta Oncol Source Type: research

Serum HER2 as an adjunct to assess HER2 status for advanced gastric cancer: A prospective multicenter trial (SHERLOCK).
CONCLUSIONS: Serum HER2 levels correlated with tissue HER2 status in gastric cancer. Although the low sensitivity is a drawback, serum HER2 might be a useful adjunct tool to detect tissue HER2 false-negative gastric cancer. PMID: 26757197 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 12, 2016 Category: Cancer & Oncology Authors: Saito M, Yamashita K, Arimura Y, Kaneto H, Okuda H, Nojima M, Hagiwara T, Suzuki K, Adachi T, Goto A, Nakachi K, Yawata A, Yoshimoto M, Tanuma T, Adachi Y, Yamaoka S, Mizukoshi T, Kawayama M, Hamamoto Y, Shinomura Y Tags: Acta Oncol Source Type: research

Can particle beam therapy be improved using helium ions? - a planning study focusing on pediatric patients.
Conclusion Treatment plan quality improved with (4)He compared to proton plans, but advantages in OAR sparing were depending on indication and tumor geometries. These first results of scanned (4)He therapy motivate comprehensive research on (4)He, including acquisition of experimental data to improve modeling of (4)He. PMID: 26750803 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - January 11, 2016 Category: Cancer & Oncology Authors: Knäusl B, Fuchs H, Dieckmann K, Georg D Tags: Acta Oncol Source Type: research

Recent developments in brain tumor predisposing syndromes.
Abstract The etiologies of brain tumors are in the most cases unknown, but improvements in genetics and DNA screening have helped to identify a wide range of brain tumor predisposition disorders. In this review we are discussing some of the most common predisposition disorders, namely: neurofibromatosis type 1 and 2, schwannomatosis, rhabdoid tumor predisposition disorder, nevoid basal cell carcinoma syndrome (Gorlin), tuberous sclerosis complex, von Hippel-Lindau, Li-Fraumeni and Turcot syndromes. Recent findings from the GLIOGENE collaboration and the newly identified glioma causing gene POT1, will also be discu...
Source: Acta Oncologica - December 3, 2015 Category: Cancer & Oncology Authors: Johansson G, Andersson U, Melin B Tags: Acta Oncol Source Type: research

Dose-surface analysis for prediction of severe acute radio-induced skin toxicity in breast cancer patients.
Abstract BACKGROUND: Severe acute radiation-induced skin toxicity (RIST) after breast irradiation is a side effect impacting the quality of life in breast cancer (BC) patients. The aim of the present study was to develop normal tissue complication probability (NTCP) models of severe acute RIST in BC patients. PATIENTS AND METHODS: We evaluated 140 consecutive BC patients undergoing conventional three-dimensional conformal radiotherapy (3D-CRT) after breast conserving surgery in a prospective study assessing acute RIST. The acute RIST was classified according to the RTOG scoring system. Dose-surface histograms...
Source: Acta Oncologica - December 1, 2015 Category: Cancer & Oncology Authors: Pastore F, Conson M, D'Avino V, Palma G, Liuzzi R, Solla R, Farella A, Salvatore M, Cella L, Pacelli R Tags: Acta Oncol Source Type: research

Prognostic value of hypoxia-regulated gene expression in loco-regional gastroesophageal cancer.
PMID: 26623712 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - December 1, 2015 Category: Cancer & Oncology Authors: Winther M, Alsner J, Tramm T, Holtved E, Baeksgaard L, Nordsmark M Tags: Acta Oncol Source Type: research

Yttrium-90 radioembolization for the treatment of chemorefractory colorectal liver metastases: Technical results, clinical outcome and factors potentially influencing survival.
CONCLUSION: (90)Y microsphere radioembolization for chemorefractory colorectal liver metastases has an acceptable safety profile with a 50% estimated survival after 8.0 months. Pretreatment high bilirubin, alkaline phosphatase and tumor volume levels were associated with early death. PMID: 26625262 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - December 1, 2015 Category: Cancer & Oncology Authors: Maleux G, Deroose C, Laenen A, Verslype C, Heye S, Haustermans K, De Hertogh G, Sagaert X, Topal B, Aerts R, Prenen H, Vanbeckevoort D, Vandecaveye V, Van Cutsem E Tags: Acta Oncol Source Type: research