Quality of life in long-term and very long-term cancer survivors versus population controls in Germany.
The objective of our study is to: (1) compare QoL of long-term cancer survivors and population norms; and (2) assess whether any deficits in QoL of survivors observed 5-10 years past diagnosis persist beyond the 10th year past diagnosis. METHODS: In total 6952 long-term cancer survivors (5-16 years past diagnosis of breast, colorectal, or prostate cancer) from Germany recruited in the context of the population-based CAESAR + study were compared with 1878 population-based controls without a history of cancer. QoL was assessed with the EORTC QLQ-C30. Differences in QoL between survivors and controls were a...
Source: Acta Oncologica - January 5, 2017 Category: Cancer & Oncology Authors: Arndt V, Koch-Gallenkamp L, Jansen L, Bertram H, Eberle A, Holleczek B, Schmid-Höpfner S, Waldmann A, Zeissig SR, Brenner H Tags: Acta Oncol Source Type: research

Methodological, biological and clinical aspects of circulating free DNA in metastatic colorectal cancer.
CONCLUSION: This paper had gathered the most recent literature on several aspects of cfDNA in mCRC, including methodological, biological and clinical aspects, and discussed the large clinical potential in this specific setting, which needs to be validated in carefully designed prospective studies in statistically relevant cohorts. PMID: 28010185 [PubMed - in process] (Source: Acta Oncologica)
Source: Acta Oncologica - December 26, 2016 Category: Cancer & Oncology Authors: Spindler KG Tags: Acta Oncol Source Type: research

New frontiers in couple-based interventions in cancer care: refining the prescription for spousal communication.
CONCLUSION: In order push this field forward, we need to develop a more nuanced view of couples' communication that acknowledges that there are multiple ways to talk, different aspects of the cancer experience to talk about, and preexisting communication patterns and preferences for different couples that may influence the utility of talk. Interventions that replace the unilateral and generic prescription to talk openly about cancer with targeted questions that prompt reflection on couples' unique strengths, preexisting communication patterns and support resources may thus help bolster the impact of couple-based interventi...
Source: Acta Oncologica - December 12, 2016 Category: Cancer & Oncology Authors: Badr H Tags: Acta Oncol Source Type: research

Risk of second cancers in survivors of prolymphocytic leukemia: a SEER data analysis.
PMID: 27924652 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - December 7, 2016 Category: Cancer & Oncology Authors: El-Fattah MA Tags: Acta Oncol Source Type: research

Healthcare resource use, comorbidity, treatment and clinical outcomes for patients with primary intracranial tumors: a Swedish population-based register study.
CONCLUSIONS: Age, comorbidity and high-grade gliomas, but not sex, were associated with decreased survival and increased use of healthcare resources. Fewer patients than aimed for in national guidelines received care according to specified lead times. The analysis of comprehensive population-based register data can be used to improve future care processes and outcomes. PMID: 27924653 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - December 7, 2016 Category: Cancer & Oncology Authors: Bergqvist J, Iderberg H, Mesterton J, Bengtsson N, Wettermark B, Henriksson R Tags: Acta Oncol Source Type: research

Assessment of ethnic differences in sunitinib outcome between Caucasian and Asian patients with metastatic renal cell carcinoma: a meta-analysis.
CONCLUSION: Ethnic differences in adverse events of sunitinib in mRCC patients existed and dose adjustment in Asian patients may be considered. PMID: 27924664 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - December 7, 2016 Category: Cancer & Oncology Authors: Liu X, Fiocco M, Swen JJ, Guchelaar HJ Tags: Acta Oncol Source Type: research

Occupational sedentariness and breast cancer risk.
CONCLUSIONS: We found that occupational sedentariness was associated with increased breast cancer risk, especially in women younger than 55 years. This may be a modifiable risk factor by planning breaks during the working day. Whether this reduces the risk of breast cancer needs to be further studied. PMID: 27919198 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - December 6, 2016 Category: Cancer & Oncology Authors: Johnsson A, Broberg P, Johnsson A, Tornberg ÅB, Olsson H Tags: Acta Oncol Source Type: research

High frequency of osteonecrosis of the jaw among denosumab-treated prostate cancer patients.
PMID: 27921521 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - December 6, 2016 Category: Cancer & Oncology Authors: Vehmanen L, Suojanen J, Kontio R, Utriainen T, Blomqvist C Tags: Acta Oncol Source Type: research

Anti-PD1 treatment in metastatic uveal melanoma in the Netherlands.
PMID: 27911126 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - December 2, 2016 Category: Cancer & Oncology Authors: van der Kooij MK, Joosse A, Speetjens FM, Hospers GA, Bisschop C, de Groot JW, Koornstra R, Blank CU, Kapiteijn E Tags: Acta Oncol Source Type: research

S-1 in combination with docetaxel and oxaliplatin in patients with advanced gastro-esophageal adenocarcinoma: two parallel phase 1/2a studies.
CONCLUSIONS: At the RD, DOS2w and DOS3w showed an acceptable safety profile in patients with aGEA. Clinical trials ID: NCT-01928524 and EudraCT 2012-005187-10. PMID: 27911128 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - December 2, 2016 Category: Cancer & Oncology Authors: Pfeiffer P, Qvortrup C, Krogh M, Schoennemann K, Vestermark LW, Jensen HA, Bjerregaard JK Tags: Acta Oncol Source Type: research

Socioeconomic position and mortality among patients with prostate cancer: influence of mediating factors.
DISCUSSION: Our study confirmed the a priori assumption that socioeconomic position is associated with increased mortality after prostate cancer. The increased mortality could largely be explained by lifestyle and clinical parameters. PMID: 27911129 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - December 2, 2016 Category: Cancer & Oncology Authors: Larsen SB, Brasso K, Christensen J, Johansen C, Tjønneland A, Friis S, Iversen P, Dalton SO Tags: Acta Oncol Source Type: research

Volumetric response of intracranial meningioma after photon or particle irradiation.
CONCLUSION: Significant volumetric shrinkage of meningiomas could be observed independently of the applied radiation modality. Long-term follow-up is recommended to evaluate further dynamic of size reduction and its correlation with outcome data. PMID: 27911139 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - December 2, 2016 Category: Cancer & Oncology Authors: Mozes P, Dittmar JO, Habermehl D, Tonndorf-Martini E, Hideghety K, Dittmar A, Debus J, Combs SE Tags: Acta Oncol Source Type: research

What is most relevant in preoperative rectal cancer chemoradiotherapy - the chemotherapy, the radiation dose or the timing to surgery?
PMID: 27879164 [PubMed - in process] (Source: Acta Oncologica)
Source: Acta Oncologica - November 25, 2016 Category: Cancer & Oncology Authors: Glimelius B Tags: Acta Oncol Source Type: research

Chronic lymphocytic leukemia presenting with hematuria.
PMID: 27846753 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - November 16, 2016 Category: Cancer & Oncology Authors: Shah BK, Rajwani T, Jha S, Fortna RR Tags: Acta Oncol Source Type: research

Accuracy requirements and uncertainties in radiotherapy: a report of the International Atomic Energy Agency.
Abstract BACKGROUND: Radiotherapy technology continues to advance and the expectation of improved outcomes requires greater accuracy in various radiotherapy steps. Different factors affect the overall accuracy of dose delivery. Institutional comprehensive quality assurance (QA) programs should ensure that uncertainties are maintained at acceptable levels. The International Atomic Energy Agency has recently developed a report summarizing the accuracy achievable and the suggested action levels, for each step in the radiotherapy process. Overview of the report: The report seeks to promote awareness and encourage quan...
Source: Acta Oncologica - November 16, 2016 Category: Cancer & Oncology Authors: van der Merwe D, Van Dyk J, Healy B, Zubizarreta E, Izewska J, Mijnheer B, Meghzifene A Tags: Acta Oncol Source Type: research

Gender-specific survival after surgical resection for early stage non-small cell lung cancer.
CONCLUSION: Overall survival did not differ significantly between males and females. Adjusted for confounding factors, we found a significantly increased mortality risk in elder patients compared to their younger counterparts. However, five-year overall survival of more than 50% for older patients with NSCLC should encourage surgical treatment also in elderly lung cancer patients. PMID: 27846762 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - November 16, 2016 Category: Cancer & Oncology Authors: Bugge A, Kongerud J, Brunborg C, Solberg S, Lund MB Tags: Acta Oncol Source Type: research

Outcomes after primary or adjuvant radiotherapy for salivary gland carcinoma.
CONCLUSION: Combined surgery and RT improves local control, local-regional control, and cause-specific survival compared with primary RT for salivary tumors. PMID: 27846763 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - November 16, 2016 Category: Cancer & Oncology Authors: Holtzman A, Morris CG, Amdur RJ, Dziegielewski PT, Boyce B, Mendenhall WM Tags: Acta Oncol Source Type: research

Impact of age, intrinsic subtype and local treatment on long-term local-regional recurrence and breast cancer mortality among low-risk breast cancer patients.
CONCLUSION: Among low-risk patients, 96% of the tumors were Luminal and the distribution of intrinsic subtypes between younger (≤45 years) and older (>45 years) patients was similar. The observed higher frequency of LRR among younger low-risk BCT patients was not associated intrinsic subtype. The 20-year breast cancer mortality was non-significant for LumA tumors among the older patients, whereas among the younger patients, LumA tumors had a comparable mortality with LumB, but lower than for Lum-HER2 + tumors. PMID: 27846764 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - November 16, 2016 Category: Cancer & Oncology Authors: Laurberg T, Alsner J, Tramm T, Jensen V, Lyngholm CD, Christiansen PM, Overgaard J Tags: Acta Oncol Source Type: research

Supraclavicular node disease is not an independent prognostic factor for survival of esophageal cancer patients treated with definitive chemoradiation.
CONCLUSION: In esophageal cancer treated with dCRT, the number of affected lymph nodes is an important independent prognostic factor, whereas involvement of a SCN is not. Supraclavicular lymph nodes should be considered as regional lymph nodes and treated with curative intent if the total number of involved lymph nodes is limited. PMID: 27842455 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - November 15, 2016 Category: Cancer & Oncology Authors: Jeene PM, Versteijne E, van Berge Henegouwen MI, Bergmann JJ, Geijsen ED, van Laarhoven HW, Hulshof MC Tags: Acta Oncol Source Type: research

Pazopanib in advanced vascular sarcomas: an EORTC Soft Tissue and Bone Sarcoma Group (STBSG) retrospective analysis.
CONCLUSION: The activity of pazopanib in AS is comparable to its reported activity in other STS subtypes. In this study, the activity of pazopanib was similar in cutaneous/non-cutaneous and in radiation/non-radiation-associated AS. In addition, pazopanib showed promising activity in HE and IS, worthy of further evaluation. PMID: 27838944 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - November 14, 2016 Category: Cancer & Oncology Authors: Kollár A, Jones RL, Stacchiotti S, Gelderblom H, Guida M, Grignani G, Steeghs N, Safwat A, Katz D, Duffaud F, Sleijfer S, van der Graaf WT, Touati N, Litière S, Marreaud S, Gronchi A, Kasper B Tags: Acta Oncol Source Type: research

Recall radiation myelitis after stereotactic radiation and dabrafenib in metastatic melanoma.
PMID: 27830981 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - November 10, 2016 Category: Cancer & Oncology Authors: Ejlsmark MW, Kristiansen C, Eriksen JG, Hansen O, Bastholt L Tags: Acta Oncol Source Type: research

The relative biological effectiveness of carbon ion irradiations of the rat spinal cord increases linearly with LET up to 99  keV/μm.
The relative biological effectiveness of carbon ion irradiations of the rat spinal cord increases linearly with LET up to 99 keV/μm. Acta Oncol. 2016 Nov 9;:1-4 Authors: Saager M, Glowa C, Peschke P, Brons S, Grün R, Scholz M, Huber PE, Debus J, Karger CP PMID: 27827542 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - November 9, 2016 Category: Cancer & Oncology Authors: Saager M, Glowa C, Peschke P, Brons S, Grün R, Scholz M, Huber PE, Debus J, Karger CP Tags: Acta Oncol Source Type: research

Abscopal effect of radiotherapy in a patient with metastatic diffuse-type giant cell tumor.
PMID: 27820978 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - November 8, 2016 Category: Cancer & Oncology Authors: Desar IM, Braam PM, Kaal SE, Gerritsen WR, Oyen WJ, van der Graaf WT Tags: Acta Oncol Source Type: research

Multimodal therapy is feasible in elderly anal cancer patients.
CONCLUSION: Patients older than 80 years develop anal cancer, but more often marginal tumors. Even in the oldest age group half of the patients can tolerate standard treatment by a combination of radiation and chemotherapy, and obtain a relative survival of 50% after five years. Fragile patients not considered candidates for chemoradiation may be offered radiation or resection to control local disease. PMID: 27808666 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - November 3, 2016 Category: Cancer & Oncology Authors: Dale JE, Sebjørnsen S, Leh S, Rösler C, Aaserud S, Møller B, Fluge Ø, Erichsen C, Nadipour S, Kørner H, Pfeffer F, Dahl O Tags: Acta Oncol Source Type: research

Trends in incidence and survival of cutaneous malignant melanoma in Estonia: a population-based study.
CONCLUSIONS: The proportion of stage I and T1 cases is lower in Estonia compared with the Scandinavian data and is likely a major contributor to the persisting overall survival deficit in Estonia. The apparent deficit in stage II survival also warrants further investigation. A public health program is necessary in Estonia to raise awareness of CM and to significantly increase early stage diagnosis. PMID: 27796149 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - October 31, 2016 Category: Cancer & Oncology Authors: Padrik P, Valter A, Valter E, Baburin A, Innos K Tags: Acta Oncol Source Type: research

Chemotherapy and intensity-modulated radiation therapy for locally advanced pancreatic cancer achieves a high rate of R0 resection.
CONCLUSION: IMRT is safe in patients with LAPC. Patients with non-progressive LAPC after ICT and who received IMRT had high rates of local control and prolonged survival. PMID: 27796165 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - October 31, 2016 Category: Cancer & Oncology Authors: Huguet F, Hajj C, Winston CB, Shi W, Zhang Z, Wu AJ, O'Reilly EM, Reidy DL, Allen P, Goodman KA Tags: Acta Oncol Source Type: research

Core needle biopsies for the diagnosis of diffuse large B-cell lymphoma - a great concern for research.
RM PMID: 27796168 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - October 31, 2016 Category: Cancer & Oncology Authors: Abdulla M, Laszlo S, Triumf J, Hedström G, Berglund M, Enblad G, Amini RM Tags: Acta Oncol Source Type: research

Hepatitis B reactivation during everolimus treatment.
PMID: 27771976 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - October 24, 2016 Category: Cancer & Oncology Authors: Mir O, Toulmonde M, Coriat R, Ropert S, Loulergue P Tags: Acta Oncol Source Type: research

Histological grade provides significant prognostic information in addition to breast cancer subtypes defined according to St Gallen 2013.
CONCLUSIONS: Patients with ER-positive/HER2-negative/G1 breast cancer have a good prognosis, similar to that of 'Luminal A-like', while those with ER-positive/HER2-negative/G3 breast cancer have a worse prognosis, similar to that of 'Luminal B-like', when assessed independently of PgR and Ki-67. Therapy decisions based on Ki-67 and PgR might thus be restricted to the subgroup G2. PMID: 27762648 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - October 20, 2016 Category: Cancer & Oncology Authors: Ehinger A, Malmström P, Bendahl PO, Elston CW, Falck AK, Forsare C, Grabau D, Rydén L, Stål O, Fernö M, South and South-East Swedish Breast Cancer Groups Tags: Acta Oncol Source Type: research

Effect of increasing radiation dose on pathologic complete response in rectal cancer patients treated with neoadjuvant chemoradiation therapy.
CONCLUSION: Our study suggests that increasing dose significantly improved pCR rates and downstaging in rectal cancer patients treated with neoadjuvant CRT followed by surgery. PMID: 27762654 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - October 20, 2016 Category: Cancer & Oncology Authors: Hall MD, Schultheiss TE, Smith DD, Fakih MG, Wong JY, Chen YJ Tags: Acta Oncol Source Type: research

Proportion and characteristics of men with unknown risk category in the National Prostate Cancer Register of Sweden.
CONCLUSION: Men with unknown risk category were rare in NPCR but distinctly different from other men in NPCR in many aspects including higher comorbidity and lower Pca mortality. PMID: 27749139 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - October 17, 2016 Category: Cancer & Oncology Authors: Tomic K, Westerberg M, Robinson D, Garmo H, Stattin P Tags: Acta Oncol Source Type: research

Lymphovascular and perineural invasion in stage II rectal cancer: a report from the Swedish colorectal cancer registry.
Abstract BACKGROUND: Adjuvant chemotherapy for stage II and III rectal cancer patients is a matter of discussion. The aim of the present study was to evaluate the prognostic value of lymphovascular (LVI) and perineural (PNI) invasion in stage II rectal cancer on a national level. MATERIALS AND METHODS: Clinico-pathological factors associated with disease-free survival (DFS) and time to recurrence in stage II rectal cancer patients were analyzed from patient data registered in the Swedish Colorectal Cancer Registry between 2006 and 2012. RESULTS: Of 2649 patients with TNM stage II disease, 1395 (53%) rece...
Source: Acta Oncologica - October 12, 2016 Category: Cancer & Oncology Authors: Nikberg M, Chabok A, Letocha H, Kindler C, Glimelius B, Smedh K Tags: Acta Oncol Source Type: research

Clinical evaluation of QUANTEC guidelines to predict the risk of cardiac mortality in breast cancer patients.
, Gagliardi G PMID: 27732122 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - October 12, 2016 Category: Cancer & Oncology Authors: Moiseenko V, Einck J, Murphy J, Ödén J, Bjöhle J, Uzan J, Gagliardi G Tags: Acta Oncol Source Type: research

Optimal gross tumor volume definition in lung-sparing intensity modulated radiotherapy for pleural mesothelioma: an in silico study.
CONCLUSION: As MRI identified additional pleural disease sites in the majority of patients, it may play a role in optimal target volume definition. PMID: 27732127 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - October 12, 2016 Category: Cancer & Oncology Authors: Botticella A, Defraene G, Nackaerts K, Deroose CM, Coolen J, Nafteux P, Peeters S, Ricardi U, De Ruysscher D Tags: Acta Oncol Source Type: research

Teenage colorectal polyposis and cancer may be caused by constitutional mismatch repair deficiency (CMMRD).
PMID: 27723366 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - October 10, 2016 Category: Cancer & Oncology Authors: Soplepmann J, Laidre P Tags: Acta Oncol Source Type: research

Physical performance measures for predicting outcome in cancer patients: a systematic review.
CONCLUSION: PPTs appear to show a significant correlation with survival and these tests could be used as a prognostic tool, particular for older adult patients. A less explicit correlation for treatment-related complications and functional decline was also found. To optimize decision making, future research should focus on developing and validating individualized treatment algorithms that incorporate PPTs in addition to cancer- and treatment-related variables. PMID: 27718777 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - October 8, 2016 Category: Cancer & Oncology Authors: Verweij NM, Schiphorst AH, Pronk A, van den Bos F, Hamaker ME Tags: Acta Oncol Source Type: research

A population-based study on incidence rates, Lauren distribution, stage distribution, treatment, and long-term outcomes for gastric adenocarcinoma in Central Norway 2001-2011.
ønbech JE Abstract BACKGROUND: Population-based studies for gastric adenocarcinoma are scarce, particularly studies conducted within a defined geographical area with publicly available censuses that allow incidence rates to be calculated. MATERIAL AND METHODS: Population-based study in Central Norway from 2001 to 2011, covering a population of 636 000-680 000, respectively. Patients were identified through the Cancer Registry of Norway and the Norwegian Patient Register, and were characterized by data from individual electronic patient records. Outcomes were compared across the early and the late half ...
Source: Acta Oncologica - October 6, 2016 Category: Cancer & Oncology Authors: Bringeland EA, Wasmuth HH, Mjønes P, Myklebust TÅ, Grønbech JE Tags: Acta Oncol Source Type: research

Electrochemotherapy of mucosal head and neck tumors: a systematic review.
CONCLUSION: Few studies concerning electrochemotherapy on mucosal head and neck tumors are available and they are not easily comparable. Overall response to treatment is good; nonetheless, further systematic studies are warranted. PMID: 27705053 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - October 5, 2016 Category: Cancer & Oncology Authors: Plaschke CC, Gothelf A, Gehl J, Wessel I Tags: Acta Oncol Source Type: research

Predictors for trismus in patients receiving radiotherapy.
CONCLUSION: Incidence of trismus is 3.6 per 10 person years at risk. Tumor localization and overall treatment time of radiotherapy are predictors for developing trismus the first six months after radiotherapy. Maximal mouth opening is a significant predictor for developing trismus at all time points. Regular measurements of maximal mouth opening are needed to predict trismus. PMID: 27627138 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - September 14, 2016 Category: Cancer & Oncology Authors: van der Geer SJ, Kamstra JI, Roodenburg JL, van Leeuwen M, Reintsema H, Langendijk JA, Dijkstra PU Tags: Acta Oncol Source Type: research

Acetyl-L-carnitine undervalued in the treatment of chemotherapy-induced peripheral neuropathy?
PMID: 27606940 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - September 8, 2016 Category: Cancer & Oncology Authors: van Dam DG, Beijers AJ, Vreugdenhil G Tags: Acta Oncol Source Type: research

Validated guidelines for tumor delineation on magnetic resonance imaging for laryngeal and hypopharyngeal cancer.
CONCLUSIONS: In clinical radiotherapy practice, the delineated GTV on MRI is twice as large as the tumor volume. Validated delineation guidelines lead to a significant decrease in the overestimation of the tumor volume. PMID: 27607138 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - September 8, 2016 Category: Cancer & Oncology Authors: Jager EA, Ligtenberg H, Caldas-Magalhaes J, Schakel T, Philippens ME, Pameijer FA, Kasperts N, Willems SM, Terhaard CH, Raaijmakers CP Tags: Acta Oncol Source Type: research

What do stakeholders need to implement shared decision making in routine cancer care? A qualitative needs assessment.
CONCLUSION: Study results show that stakeholders voiced a diversity of needs to foster implementation of SDM in routine cancer care, of which some can be directly addressed by intervention strategies. Present results can be used to develop an implementation program to foster SDM in routine cancer care. PMID: 27607314 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - September 8, 2016 Category: Cancer & Oncology Authors: Müller E, Hahlweg P, Scholl I Tags: Acta Oncol Source Type: research

Dose-volume analysis of radiation-induced trismus in head and neck cancer patients.
CONCLUSION: Mean radiation dose to the ipsilateral masseter muscle is an important risk factor for trismus development. Dose reduction to this structure during radiotherapy should have a potential to diminish the prevalence of trismus in this patient group. PMID: 27595312 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - September 5, 2016 Category: Cancer & Oncology Authors: Gebre-Medhin M, Haghanegi M, Robért L, Kjellén E, Nilsson P Tags: Acta Oncol Source Type: research

Analysis of relation between hypoxia PET imaging and tissue-based biomarkers during head and neck radiochemotherapy.
CONCLUSION: Expression of Ku80, CAIX and CD44 as assessed by immunohistochemistry of tumor biopsies were not correlated to one another or the biological imaging data. However, there was a significant influence of CAIX on overall survival and between CD44 and HPV. PMID: 27593107 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - September 3, 2016 Category: Cancer & Oncology Authors: Bittner MI, Wiedenmann N, Bucher S, Hentschel M, Mix M, Rücker G, Weber WA, Meyer PT, Werner M, Grosu AL, Kayser G Tags: Acta Oncol Source Type: research

Proposal for magnetic resonance imaging-guided salvage radiotherapy for prostate cancer.
Abstract BACKGROUND: A subset of patients experience a biochemical recurrence following radical prostatectomy. Radiotherapy can salvage those patients, provided that all disease is encompassed within the target volume. We hypothesized that this can be achieved more adequately with magnetic resonance imaging (MRI)-guided treatment planning. MATERIAL AND METHODS: From January 2009 to April 2014, 183 patients were referred to our department for salvage radiotherapy (SRT). According to protocol, patients received a planning computed tomography (CT) as well as an MRI in treatment position. All MRI scans were retro...
Source: Acta Oncologica - September 1, 2016 Category: Cancer & Oncology Authors: Dirix P, van Walle L, Deckers F, Van Mieghem F, Buelens G, Meijnders P, Huget P, Van Laere S Tags: Acta Oncol Source Type: research

Radiation-induced morbidity evaluated by high-frequency ultrasound.
PMID: 27581725 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - September 1, 2016 Category: Cancer & Oncology Authors: Schack LH, Alsner J, Overgaard J, Andreassen CN, Offersen BV Tags: Acta Oncol Source Type: research

Nomogram for predicting recurrence in stage II colorectal cancer.
CONCLUSIONS: Our nomogram can be a useful tool for accurate prediction of recurrence in stage II colorectal cancer. PMID: 27581839 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - September 1, 2016 Category: Cancer & Oncology Authors: Hoshino N, Hasegawa S, Hida K, Kawada K, Ganeko R, Sugihara K, Sakai Y Tags: Acta Oncol Source Type: research

Lovastatin may reduce the risk of erectile dysfunction following radiation therapy for prostate cancer.
PMID: 27582017 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - September 1, 2016 Category: Cancer & Oncology Authors: Anscher MS, Chang MG, Moghanaki D, Rosu M, Mikkelsen RB, Holdford D, Skinner V, Grob BM, Sanyal A, Wang A, Mukhopadhyay ND Tags: Acta Oncol Source Type: research

Considerable pancreatic tumor motion during breath-holding.
CONCLUSION: We observed substantial pancreatic tumor motion during BH as well as considerable position variation between consecutive BHs on a single day. We recommend further quantifying these uncertainties before introducing breath-hold during radiation treatment of pancreatic cancer patients. Also, the diaphragm cannot be used as a surrogate for pancreatic tumor motion. PMID: 27583771 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - September 1, 2016 Category: Cancer & Oncology Authors: Lens E, van der Horst A, Versteijne E, Bel A, van Tienhoven G Tags: Acta Oncol Source Type: research

Age-related systemic treatment and survival of patients with metachronous metastases from colorectal cancer.
Abstract BACKGROUND: Although the spectrum of systemic treatment for metastatic colorectal cancer (mCRC) has widened, there is a paucity of evidence for the feasibility and optimal use of these systemic agents in elderly patients. The present study provides real world data on the age-related systemic treatment and survival of CRC patients with non-resectable metachronous metastases. METHODS: All consecutive patients with non-resectable metastases from primary resected CRC were extracted from the Eindhoven area of the Netherlands Cancer Registry (NCR). Patients receiving palliative systemic therapy were enroll...
Source: Acta Oncologica - September 1, 2016 Category: Cancer & Oncology Authors: Razenberg LG, Creemers GJ, Beerepoot LV, Vos AH, van de Wouw AJ, Maas HA, Lemmens VE Tags: Acta Oncol Source Type: research