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An Exploration of the Impact of Anticentromere Antibody on Early-Stage Embryo.
Conclusion: Mouse embryos may be a direct target for ACA in vitro prior to implantation. However, the precise mechanism needs further clarification. PMID: 29119119 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - November 10, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Computer-Aided Design of an Epitope-Based Vaccine against Epstein-Barr Virus.
Authors: Alonso-Padilla J, Lafuente EM, Reche PA Abstract Epstein-Barr virus is a very common human virus that infects 90% of human adults. EBV replicates in epithelial and B cells and causes infectious mononucleosis. EBV infection is also linked to various cancers, including Burkitt's lymphoma and nasopharyngeal carcinomas, and autoimmune diseases such as multiple sclerosis. Currently, there are no effective drugs or vaccines to treat or prevent EBV infection. Herein, we applied a computer-aided strategy to design a prophylactic epitope vaccine ensemble from experimentally defined T and B cell epitopes. Such strat...
Source: Journal of Immunology Research - November 10, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Cytokine Profile of Patients with Allergic Rhinitis Caused by Pollen, Mite, and Microbial Allergen Sensitization.
Authors: Tyurin YA, Lissovskaya SA, Fassahov RS, Mustafin IG, Shamsutdinov AF, Shilova MA, Rizvanov AA Abstract Allergic rhinitis (AR) is especially prevalent among the population of large cities. Immunologically, the airway epithelium is a region where the population of allergen-presenting cells concentrates. These cells actively express a group of receptors of the innate immune system. A specific cytokine profile is its representation. The study was aimed at evaluating the cytokine profile in patients with seasonal and perennial allergic rhinitis. The cytokine profile of nasal secretion and blood serum of 44 pati...
Source: Journal of Immunology Research - November 9, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Immunotherapy as a Promising Treatment for Prostate Cancer: A Systematic Review.
Authors: Janiczek M, Szylberg Ł, Kasperska A, Kowalewski A, Parol M, Antosik P, Radecka B, Marszałek A Abstract Prostate cancer treatment is currently based on surgical removal, radiotherapy, and hormone therapy. In recent years, another therapeutic method has emerged-immunological treatment. Immunotherapy modulates and strengthens one's immune responses against cancer. Neoplastic cells naturally escape from the control of the immune system, and the main goal of immune therapy is to bring the control back. Satisfying outcomes after treatment of advanced melanoma and lung cancer suggest a great potential of immuno...
Source: Journal of Immunology Research - November 9, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

A Novel System for the Quantification of the ADCC Activity of Therapeutic Antibodies.
Authors: Lallemand C, Liang F, Staub F, Simansour M, Vallette B, Huang L, Ferrando-Miguel R, Tovey MG Abstract Novel ADCC effector cells expressing the V-variant or F-variant of FcγRIIIa (CD16a) and firefly luciferase under the control of a chimeric promoter incorporating recognition sequences for the principal transcription factors involved in FcγRIIIa signal transduction, together with novel target cells overexpressing a constant high level of the specific antigen recognized by rituximab, trastuzumab, cetuximab, infliximab, adalimumab, or etanercept, confer improved sensitivity, specificity, and dynam...
Source: Journal of Immunology Research - November 8, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Maternal and Perinatal Outcome in Women with Systemic Lupus Erythematosus: A Retrospective Bicenter Cohort Study.
Conclusion: In this SLE population with low disease activity, pregnancy complications were present irrespective of antiphospholipid antibody status. Furthermore, there were no differences in complication rates between the first and consecutive pregnancies as seen in healthy mothers. This information is useful for patient counseling. PMID: 29094052 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - November 3, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

The Hydroalcoholic Extract Obtained from Mentha piperita L. Leaves Attenuates Oxidative Stress and Improves Survival in Lipopolysaccharide-Treated Macrophages.
Authors: Arruda MO, Mendes SJF, Teixeira SA, de Mesquita LSS, de Sousa Ribeiro MN, Galvão SSL, Muscará MN, Fernandes ES, Monteiro-Neto V Abstract Mentha piperita L. (peppermint) possesses antimicrobial properties, but little is known of its ability to modulate macrophages. Macrophages are essential in bacterial infection control due to their antimicrobial functions and ability to link the innate and adaptive immune responses. We evaluated the effects of the peppermint leaf hydroalcoholic extract (LHAE) on cultured murine peritoneal macrophages stimulated or not with lipopolysaccharide (LPS) in vitro. ...
Source: Journal of Immunology Research - November 2, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Vaccinomics Approach for Designing Potential Peptide Vaccine by Targeting Shigella spp. Serine Protease Autotransporter Subfamily Protein SigA.
Authors: Oany AR, Pervin T, Mia M, Hossain M, Shahnaij M, Mahmud S, Kibria KMK Abstract Shigellosis, a bacillary dysentery, is closely associated with diarrhoea in human and causes infection of 165 million people worldwide per year. Casein-degrading serine protease autotransporter of enterobacteriaceae (SPATE) subfamily protein SigA, an outer membrane protein, exerts both cytopathic and enterotoxic effects especially cytopathic to human epithelial cell type-2 (HEp-2) and is shown to be highly immunogenic. In the present study, we have tried to impose the vaccinomics approach for designing a common peptide vaccine c...
Source: Journal of Immunology Research - October 31, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Dendritic Cells in Sepsis: Pathological Alterations and Therapeutic Implications.
Authors: Wu DD, Li T, Ji XY Abstract Sepsis is the leading cause of death for critically ill patients in recent years. Dendritic cells (DCs) are important antigen-presenting cells and play a key role in immune response by regulating the innate and adaptive immunity. The number of DCs, the differentiation of monocytes into DCs, and the levels of surface molecules associated with the function of DCs are changed in the development of sepsis. There are many mechanisms involved in the alterations of DCs during sepsis, including the induction of apoptosis, reactive oxygen species generation, activation of the Wnt signali...
Source: Journal of Immunology Research - October 29, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Enavatuzumab, a Humanized Anti-TWEAK Receptor Monoclonal Antibody, Exerts Antitumor Activity through Attracting and Activating Innate Immune Effector Cells.
Authors: Ye S, Fox MI, Belmar NA, Sho M, Chao DT, Choi D, Fang Y, Zhao V, Keller SF, Starling GC, Culp PA Abstract Enavatuzumab is a humanized IgG1 anti-TWEAK receptor monoclonal antibody that was evaluated in a phase I clinical study for the treatment of solid malignancies. The current study was to determine whether and how myeloid effector cells were involved in postulated mechanisms for its potent antitumor activity in xenograft models. The initial evidence for a role of effector cells was obtained in a subset of tumor xenograft mouse models whose response to enavatuzumab relied on the binding of Fc of the antib...
Source: Journal of Immunology Research - October 29, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Propyl Gallate Exerts an Antimigration Effect on Temozolomide-Treated Malignant Glioma Cells through Inhibition of ROS and the NF- κB Pathway.
In this study, we demonstrated that temozolomide (TMZ) and propyl gallate (PG) combination enhanced the inhibition of migration in human U87MG glioma cells. PG inhibited the TMZ-induced reactive oxygen species (ROS) generation. The mitochondrial complex III and NADPH oxidase are two critical sites that can be considered to regulate antimigration in TMZ-treated U87MG cells. PG can enhance the antimigration effect of TMZ through suppression of metalloproteinase-2 and metalloproteinase-9 activities, ROS generation, and the NF-κB pathway and possibly provide a novel prospective strategy for treating malignant glioma. ...
Source: Journal of Immunology Research - October 26, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Traditional Chinese Medicine Protects against Cytokine Production as the Potential Immunosuppressive Agents in Atherosclerosis.
Authors: Ren Y, Qiao W, Fu D, Han Z, Liu W, Ye W, Liu Z Abstract Atherosclerosis is a chronic inflammatory disease caused by dyslipidemia and mediated by both innate and adaptive immune responses. Inflammation is a critical factor at all stages of atherosclerosis progression. Proinflammatory cytokines accelerate atherosclerosis progression, while anti-inflammatory cytokines ameliorate the disease. Accordingly, strategies to inhibit immune activation and impede immune responses towards anti-inflammatory activity are an alternative therapeutic strategy to conventional chemotherapy on cardiocerebrovascular outcomes. S...
Source: Journal of Immunology Research - October 20, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Intestinal Dysbiosis and Rheumatoid Arthritis: A Link between Gut Microbiota and the Pathogenesis of Rheumatoid Arthritis.
Authors: Horta-Baas G, Romero-Figueroa MDS, Montiel-Jarquín AJ, Pizano-Zárate ML, García-Mena J, Ramírez-Durán N Abstract Characterization and understanding of gut microbiota has recently increased representing a wide research field, especially in autoimmune diseases. Gut microbiota is the major source of microbes which might exert beneficial as well as pathogenic effects on human health. Intestinal microbiome's role as mediator of inflammation has only recently emerged. Microbiota has been observed to differ in subjects with early rheumatoid arthritis compared to controls, and th...
Source: Journal of Immunology Research - September 29, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Chinese Herbal Formula, Modified Danggui Buxue Tang, Attenuates Apoptosis of Hematopoietic Stem Cells in Immune-Mediated Aplastic Anemia Mouse Model.
In conclusion, DGBX can relieve the immune-mediated destruction of HSCs, repair hematopoietic failure, and recover the hematopoietic function of HSCs in hematogenesis. Therefore, DGBX can be used in traditional medicine against AA as a complementary and alternative immunosuppressive therapeutic formula. PMID: 28951880 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - September 29, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

In Vitro Immunomodulatory Activity of a Transition-State Analog Inhibitor of Human Purine Nucleoside Phosphorylase in Cutaneous Leishmaniasis.
Authors: Carvalho NB, de Oliveira Prates FV, da Silva RC, Dourado MEF, Amorim CF, Machado PRL, Pacheco FG, Corte TWF, Machado P, Santos DS, de Carvalho EM Abstract Cutaneous leishmaniasis (CL) is the most common clinical form of American tegumentary leishmaniasis caused by Leishmania (Viannia) braziliensis. CL is associated with a strong Th1 immune response. This exacerbated inflammatory response is correlated with severity of disease and delays the healing time of the ulcer. The fourth-generation immucillin derivative (DI4G), a potent inhibitor of purine nucleoside phosphorylase, has been proposed as a promising a...
Source: Journal of Immunology Research - September 22, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

The Humoral Theory of Transplantation.
Authors: Ravindranath MH, Cai J, Ferrone S, Claas FHJ, Selvan SR PMID: 28929124 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - September 22, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

The Differential Contribution of the Innate Immune System to a Good Pathological Response in the Breast and Axillary Lymph Nodes Induced by Neoadjuvant Chemotherapy in Women with Large and Locally Advanced Breast Cancers.
Authors: Kaewkangsadan V, Verma C, Eremin JM, Cowley G, Ilyas M, Satthaporn S, Eremin O Abstract The tumour microenvironment consists of malignant cells, stroma, and immune cells. The role of adaptive immunity in inducing a pathological complete response (pCR) in breast cancer with neoadjuvant chemotherapy (NAC) is well studied. The contribution of innate immunity, however, is poorly documented. Breast tumours and axillary lymph nodes (ALNs) from 33 women with large and locally advanced breast cancers (LLABCs) undergoing NAC were immunohistochemically assessed for tumour-infiltrating macrophages (TIMs: M1 and M2), ...
Source: Journal of Immunology Research - September 17, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Efficacy of Tumor-Infiltrating Lymphocytes Combined with IFN- α in Chinese Resected Stage III Malignant Melanoma.
CONCLUSION: Patients who undergo surgical excision of stage III MM appear to enjoy prolonged DFS and OS when treated with TIL + IFN-α compared to IFN-α alone. PMID: 28913367 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - September 17, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Erratum to "Low Baseline Interleukin-17A Levels Are Associated with Better Treatment Response at 12 Weeks to Tocilizumab Therapy in Rheumatoid Arthritis Patients".
Erratum to "Low Baseline Interleukin-17A Levels Are Associated with Better Treatment Response at 12 Weeks to Tocilizumab Therapy in Rheumatoid Arthritis Patients". J Immunol Res. 2017;2017:7869412 Authors: Lee SJ, Park W, Park SH, Shim SC, Baek HJ, Yoo DH, Kim HA, Lee SK, Lee YJ, Park YE, Cha HS, Park JK, Lee EY, Lee EB, Song YW Abstract [This corrects the article DOI: 10.1155/2015/487230.]. PMID: 28913368 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - September 17, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

SIAE Rare Variants in Juvenile Idiopathic Arthritis and Primary Antibody Deficiencies.
Authors: Sevdali E, Tsitsami E, Tsinti M, Farmaki E, Papadopoulou-Alataki E, Germenis AE, Speletas M Abstract Sialic acid acetylesterase (SIAE) deficiency was suggested to lower the levels of ligands for sialic acid-binding immunoglobulin-like receptors, decreasing the threshold for B-cell activation. In humans, studies of rare heterozygous loss-of-function mutations in SIAE gene in common autoimmune diseases, including juvenile idiopathic arthritis (JIA), yielded inconsistent results. Considering the distinct pathogenesis of the two main subtypes of JIA, autoinflammatory systemic (sJIA) and autoimmune oligo/polyar...
Source: Journal of Immunology Research - September 14, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Natural Modulators of Endosomal Toll-Like Receptor-Mediated Psoriatic Skin Inflammation.
Authors: Lai CY, Su YW, Lin KI, Hsu LC, Chuang TH Abstract Psoriasis is a chronic inflammatory autoimmune disease that can be initiated by excessive activation of endosomal toll-like receptors (TLRs), particularly TLR7, TLR8, and TLR9. Therefore, inhibitors of endosomal TLR activation are being investigated for their ability to treat this disease. The currently approved biological drugs adalimumab, etanercept, infliximab, ustekinumab, ixekizumab, and secukizumab are antibodies against effector cytokines that participate in the initiation and development of psoriasis. Several immune modulatory oligonucleotides and s...
Source: Journal of Immunology Research - September 13, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Cereblon: A Protein Crucial to the Multiple Functions of Immunomodulatory Drugs as well as Cell Metabolism and Disease Generation.
Authors: Shi Q, Chen L Abstract It is well known that cereblon is a key protein in autosomal recessive nonsyndromic mental retardation. Studies have reported that it has an intermediary role in helping immunomodulatory drugs perform their immunomodulatory and tumoricidal effects. In addition, cereblon also regulates the expression, assembly, and activities of other special proteins related to cell proliferation and metabolism, resulting in the occurrence and development of metabolic diseases. This review details the multiple functions of cereblon and the underlying mechanisms. We also put forward some unsolved prob...
Source: Journal of Immunology Research - September 13, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Intracellular pH Regulates TRAIL-Induced Apoptosis and Necroptosis in Endothelial Cells.
Authors: Zhang ZX, Gan I, Pavlosky A, Huang X, Fuhrmann B, Jevnikar AM Abstract During ischemia or inflammation of organs, intracellular pH can decrease if acid production exceeds buffering capacity. Thus, the microenvironment can expose parenchymal cells to a reduced extracellular pH which can alter pH-dependent intracellular functions. We have previously shown that while silencing caspase-8 in an in vivo ischemia reperfusion injury (IRI) model results in improved organ function and survival, removal of caspase-8 function in a donor organ can paradoxically result in enhanced receptor-interacting protein kinase 1/3...
Source: Journal of Immunology Research - September 10, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Beneficial Effects of Prebiotic Saccharomyces cerevisiae Mannan on Allergic Asthma Mouse Models.
Authors: Lew DB, Michael CF, Overbeck T, Robinson WS, Rohman EL, Lehman JM, Patel JK, Eiseman B, LeMessurier KS, Samarasinghe AE, Gaber MW Abstract One of the unmet needs for asthma management is a new therapeutic agent with both anti-inflammatory and anti-smooth muscle (ASM) remodeling effects. The mannose receptor (MR) family plays an important role in allergen uptake and processing of major allergens Der p 1 and Fel d 1. We have previously reported that ASM cells express a mannose receptor (ASM-MR) and that mannan derived from Saccharomyces cerevisiae (SC-MN) inhibits mannosyl-rich lysosomal hydrolase-induced bo...
Source: Journal of Immunology Research - August 25, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

The Microbiome in Connective Tissue Diseases and Vasculitides: An Updated Narrative Review.
CONCLUSIONS: Numerous studies suggest that alterations in human microbiota may be involved in the pathogenesis of inflammatory arthritides as a result of the aberrant activation of the innate and adaptive immune responses. Only a few studies have explored the involvement of dysbiosis in other CTDs or vasculitides, and further research is needed. PMID: 28835902 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - August 25, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Safety of Human Papillomavirus 9-Valent Vaccine: A Meta-Analysis of Randomized Trials.
Authors: Costa APF, Cobucci RNO, da Silva JM, da Costa Lima PH, Giraldo PC, Gonçalves AK Abstract Vaccination against human papillomavirus (HPV) has been progressively implemented in most developed countries for approximately 10 years. In order to increase the protection of the vaccines, a 9-valent vaccine (HPV9) was developed, which provides protection against nine types of the virus. Studies evaluating its safety are rare. Thus, we performed a meta-analysis of three clinical trials assessing adverse effects on women randomly vaccinated with HPV9 or tetravalent vaccine (HPV4), with the objective of analyzin...
Source: Journal of Immunology Research - August 18, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Saliva-Derived Host Defense Peptides Histatin1 and LL-37 Increase Secretion of Antimicrobial Skin and Oral Mucosa Chemokine CCL20 in an IL-1 α-Independent Manner.
In this study, we investigated the effect of two salivary HDPs, LL-37 and Hst1, on the inflammatory and antimicrobial response by skin and oral mucosa (gingiva) keratinocytes and fibroblasts. The potent antimicrobial chemokine CCL20 was investigated and compared with chemokines CCL2, CXCL1, CXCL8, and CCL27 and proinflammatory cytokines IL-1α and IL-6. Keratinocyte-fibroblast cocultures showed a synergistic increase in CCL20 secretion upon Hst1 and LL-37 exposure compared to monocultures. These cocultures also showed increased IL-6, CXCL1, CXCL8, and CCL2 secretion, which was IL-1α dependent. Secretion of the a...
Source: Journal of Immunology Research - August 18, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Low Dose of Lipopolysaccharide Pretreatment Preventing Subsequent Endotoxin-Induced Uveitis Is Associated with PI3K/AKT Pathway.
CONCLUSIONS: LPS pretreatment can ameliorate endotoxin-induced uveitis in rats. This protection of endotoxin tolerance against EIU is associated with PI3K/AKT pathway by reducing level of TNF-α in the aqueous humor. PMID: 28804726 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - August 15, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Synergistic Antitumour Properties of viscumTT in Alveolar Rhabdomyosarcoma.
Authors: Stammer RM, Kleinsimon S, Rolff J, Jäger S, Eggert A, Seifert G, Delebinski CI Abstract Aqueous mistletoe extracts from the European mistletoe (Viscum album) contain mainly mistletoe lectins and viscotoxins as cytotoxic compounds. Lipophilic triterpene acids, which do not occur in conventional mistletoe preparations, were solubilised with β-cyclodextrins. The combination of an aqueous extract (viscum) and a triterpene-containing extract (TT) recreated a whole mistletoe extract (viscumTT). These extracts were tested on rhabdomyosarcoma in vitro, ex vivo, and in vivo with regard to anticancer effec...
Source: Journal of Immunology Research - August 11, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Characterization of Interleukin-15-Transpresenting Dendritic Cells for Clinical Use.
In this study, we demonstrate that upon electroporation with both IL-15 and IL-15Rα-encoding messenger RNA, mature DC become highly positive for surface IL-15, without influencing the expression of prototypic mature DC markers and with preservation of their cytokine-producing capacity and their migratory profile. Functionally, we show that IL-15-transpresenting DC are equal if not better inducers of T-cell proliferation and are superior in tumor antigen-specific T-cell activation compared with DC without IL-15 conditioning. In view of the clinical use of DC vaccines, we evidence with a time- and cost-effective manner...
Source: Journal of Immunology Research - August 10, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Mahuang Fuzi Xixin Decoction Attenuates Th1 and Th2 Responses in the Treatment of Ovalbumin-Induced Allergic Inflammation in a Rat Model of Allergic Rhinitis.
This study investigated the effect and possible therapeutic mechanisms of MFXD in the treatment of AR. A Wistar rat model of ovalbumin- (OVA-) induced AR was established and then treated with three doses of MFXD; AR symptoms, serum total immunoglobulin E, histamine, histopathological features, and release and expression of factors related to type 1 helper T (Th1) and type 2 helper T (Th2) responses were analyzed. Our study demonstrated that MFXD has a good therapeutic effect on OVA-induced allergic inflammation in an AR rat model as manifested in reduced frequencies of sneezing and nasal scratching and in reduced serum lev...
Source: Journal of Immunology Research - August 10, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Immunomodulatory Effects of Taiwanese Neolitsea Species on Th1 and Th2 Functionality.
This study aimed to evaluate the immunomodulatory properties of ten Taiwanese Neolitsea plants on T helper (Th) cell functionality, especially Th1 and Th2. Most of the 29 crude extracts of Neolitsea were not toxic to splenocytes, except N. buisanensis roots. N. aciculata and N. villosa leaf extracts possessed differential immunomodulatory effects on Th1/Th2 balance. N. aciculata var. variabillima and N. hiiranensis leaf extracts attenuated both Th1 and Th2 cytokines while N. konishii dramatically suppressed IFN-γ production. As N. aciculata var. variabillima and N. konishii leaf extracts significantly attenuated Th1 ...
Source: Journal of Immunology Research - August 8, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Hypoxic Modulation of HLA-G Expression through the Metabolic Sensor HIF-1 in Human Cancer Cells.
Authors: Garziera M, Scarabel L, Toffoli G Abstract The human leukocyte antigen-G (HLA-G) is considered an immune checkpoint molecule involved in tumor immune evasion. Hypoxia and the metabolic sensor hypoxia-inducible factor 1 (HIF-1) are hallmarks of metastasization, angiogenesis, and intense tumor metabolic activity. The purpose of this review was to examine original in vitro studies carried out in human cancer cell lines, which reported data about HLA-G expression and HIF-1 mediated-HLA-G expression in response to hypoxia. The impact of HLA-G genomic variability on the hypoxia responsive elements (HREs) specifi...
Source: Journal of Immunology Research - August 8, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Airway Epithelial Repair by a Prebiotic Mannan Derived from Saccharomyces cerevisiae.
Authors: Michael CF, Waters CM, LeMessurier KS, Samarasinghe AE, Song CY, Malik KU, Lew DB Abstract In asthmatic airways, repeated epithelial damage and repair occur. No current therapy directly targets this process. We aimed to determine the effects of mannan derived from S. cerevisiae (SC-MN) on airway epithelial wound repair, in vitro. The presence of functional mannose receptors in bronchial epithelial cells was shown by endocytosis of colloidal gold-Man BSA via clathrin-coated pits in 16HBE cells. In primary normal human bronchial epithelial cells (NHBEC), SC-MN significantly facilitated wound closure. Treatme...
Source: Journal of Immunology Research - August 5, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

New Insights for Immune-Based Diagnosis and Therapy for Infectious Diseases.
Authors: Sautto GA, Diotti RA, Wisskirchen K, Kahle KM PMID: 28758132 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - August 3, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Probiotic Lactobacillus Strains Stimulate the Inflammatory Response and Activate Human Macrophages.
In this study, we analyzed the mechanism by which four different strains of probiotics affected innate immunity, such as regulation of ROS, cytokines, phagocytosis, bactericidal activity, signaling by NF-κB pp65, and TLR2 activation. The production of ROS was dependent on the concentration and species of Lactobacillus. The results obtained from the tested strains (Lactobacillus rhamnosus GG, L. rhamnosus KLSD, L. helveticus IMAU70129, and L. casei IMAU60214) showed that strains induced early proinflammatory cytokines such as IL-8,TNF-α, IL-12p70, and IL-6. However, IL-1β expression was induced only by L. h...
Source: Journal of Immunology Research - August 3, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Polymorphism rs2073618 of the TNFRSF11B (OPG) Gene and Bone Mineral Density in Mexican Women with Rheumatoid Arthritis.
Authors: Nava-Valdivia CA, Saldaña-Cruz AM, Corona-Sanchez EG, Murillo-Vazquez JD, Moran-Moguel MC, Salazar-Paramo M, Perez-Guerrero EE, Vazquez-Villegas ML, Bonilla-Lara D, Rocha-Muñoz AD, Martín-Marquez BT, Sandoval-Garcia F, Martínez-García EA, Fajardo-Robledo NS, Ponce-Guarneros JM, Ramirez-Villafaña M, Alcaraz-Lopez MF, Gonzalez-Lopez L, Gamez-Nava JI Abstract Osteoporosis (OP) is highly prevalent in rheumatoid arthritis (RA) and is influenced by genetic factors. Single-nucleotide polymorphism (SNP) rs2073618 in the TNFRSF11B osteoprotegerin (OPG) gene has been related...
Source: Journal of Immunology Research - August 3, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Effect of Chitosan and Liposome Nanoparticles as Adjuvant Codelivery on the Immunoglobulin G Subclass Distribution in a Mouse Model.
CONCLUSIONS: The chitosan and liposome nanoparticles as adjuvant codelivery were successfully synthesized. These nanoparticles have different shapes in particle formation, liposome nanoparticle with their unilamellar shape and chitosan nanoparticles in large shape due to the aggregation of small-size particles. Codelivery of chitosan nanoparticles has more effect on the IgG subclass antibody production than that of liposome nanoparticles in a mouse model. PMID: 28758135 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - August 3, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Therapeutic Effects of Methanol Extract from Euphorbia kansui Radix on Imiquimod-Induced Psoriasis.
In conclusion, EKC ameliorated the symptoms of psoriasis through inhibition of Th17 differentiation and activation of dendritic cells. These effects are expected to be beneficial in the treatment and prevention of psoriasis. PMID: 28761880 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - August 3, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Corrigendum to "Are the Two Human Papillomavirus Vaccines Really Similar? A Systematic Review of Available Evidence: Efficacy of the Two Vaccines against HPV".
Corrigendum to "Are the Two Human Papillomavirus Vaccines Really Similar? A Systematic Review of Available Evidence: Efficacy of the Two Vaccines against HPV". J Immunol Res. 2017;2017:4583487 Authors: Di Mario S, Basevi V, Lopalco PL, Balduzzi S, D'Amico R, Magrini N Abstract [This corrects the article DOI: 10.1155/2015/435141.]. PMID: 28744473 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - July 28, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Role of Interferons in the Development of Diagnostics, Vaccines, and Therapy for Tuberculosis.
Authors: Chin KL, Anis FZ, Sarmiento ME, Norazmi MN, Acosta A Abstract Tuberculosis (TB) is an airborne infection caused by Mycobacterium tuberculosis (Mtb). About one-third of the world's population is latently infected with TB and 5-15% of them will develop active TB in their lifetime. It is estimated that each case of active TB may cause 10-20 new infections. Host immune response to Mtb is influenced by interferon- (IFN-) signaling pathways, particularly by type I and type II interferons (IFNs). The latter that consists of IFN-γ has been associated with the promotion of Th1 immune response which is associa...
Source: Journal of Immunology Research - July 19, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Adoptive Cell Therapy of Induced Regulatory T Cells Expanded by Tolerogenic Dendritic Cells on Murine Autoimmune Arthritis.
CONCLUSION: This study highlights the potential therapeutic utility of iTregmtDC in autoimmune arthritis and should facilitate the future design of iTreg immunotherapeutic strategies. PMID: 28702462 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - July 15, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Ethyl Caffeate Ameliorates Collagen-Induced Arthritis by Suppressing Th1 Immune Response.
Conclusion. Our results indicated that ECF exerted antiarthritic potential in collagen-induced arthritis by suppressing Th1 immune response and interferon-γ-related signaling. PMID: 28706956 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - July 15, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

The Controversial C5a Receptor C5aR2: Its Role in Health and Disease.
Authors: Zhang T, Garstka MA, Li K Abstract After the discovery of the C5a receptor C5aR1, C5aR2 is the second receptor found to bind C5a and its des-arginine form. As a heptahelical G protein-coupled receptor but devoid of the intracellular Gα signal, C5aR2 is special and confusing. Ramifications and controversies about C5aR2 are under debate since its identification, from putative ligands and cellular localization to intracellular signals and pathological roles in inflammation and immunity. The ruleless and even conflicting pro- or anti-inflammatory role of C5aR2 in animal models of diverse diseases makes o...
Source: Journal of Immunology Research - July 15, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Immunomodulating and Revascularizing Activity of Kalanchoe pinnata Synergize with Fungicide Activity of Biogenic Peptide Cecropin P1.
Authors: Zakharchenko NS, Belous AS, Biryukova YK, Medvedeva OA, Belyakova AV, Masgutova GA, Trubnikova EV, Buryanov YI, Lebedeva AA Abstract Previously transgenic Kalanchoe pinnata plants producing an antimicrobial peptide cecropin P1 (CecP1) have been reported. Now we report biological testing K. pinnata extracts containing CecP1 as a candidate drug for treatment of wounds infected with Candida albicans. The drug constitutes the whole juice from K. pinnata leaves (not ethanol extract) sterilized with nanofiltration. A microbicide activity of CecP1 against an animal fungal pathogen in vivo was demonstrated for the...
Source: Journal of Immunology Research - July 12, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Mechanisms of Extracellular Immunomodulation Mediated by Infectious Agents.
Authors: Viejo-Borbolla A, Schildberg FA, Burgert HG PMID: 28685152 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - July 9, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Innate Immune Response in Kidney Ischemia/Reperfusion Injury: Potential Target for Therapy.
Authors: Kezić A, Stajic N, Thaiss F Abstract Acute kidney injury caused by ischemia and subsequent reperfusion is associated with a high rate of mortality and morbidity. Ischemia/reperfusion injury in kidney transplantation causes delayed graft function and is associated with more frequent episodes of acute rejection and progression to chronic allograft nephropathy. Alloantigen-independent inflammation is an important process, participating in pathogenesis of injurious response, caused by ischemia and reperfusion. This innate immune response is characterized by the activity of classical cells belonging to the imm...
Source: Journal of Immunology Research - July 6, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Clinical Relevance of HLA Antibodies in Kidney Transplantation: Recent Data from the Heidelberg Transplant Center and the Collaborative Transplant Study.
Authors: Süsal C, Fichtner A, Tönshoff B, Mehrabi A, Zeier M, Morath C Abstract Herein, we summarize our recent findings from the international Collaborative Transplant Study (CTS) and Heidelberg Transplant Center regarding the role of HLA antibodies in kidney transplantation and their application into the clinical routine. Based on the antibody findings from the CTS serum study, an algorithm was developed in 2006 for the transplantation of high-risk sensitized patients at the Heidelberg Transplant Center which includes seven different pre- and posttransplant measures. Using this algorithm, the number of ...
Source: Journal of Immunology Research - July 1, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Chitinase-3-Like Protein 1 (YKL-40) Reflects the Severity of Symptoms in Atopic Dermatitis.
This study has shown that YKL-40 serum level is increased in patients with atopic dermatitis and reflects the severity of symptoms. PMID: 28660216 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - July 1, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Validation of a Novel Immunoline Assay for Patient Stratification according to Virulence of the Infecting Helicobacter pylori Strain and Eradication Status.
Authors: Formichella L, Romberg L, Meyer H, Bolz C, Vieth M, Geppert M, Göttner G, Nölting C, Schepp W, Schneider A, Ulm K, Wolf P, Holster IL, Kuipers EJ, Birkner B, Soutschek E, Gerhard M Abstract Helicobacter pylori infection shows a worldwide prevalence of around 50%. However, only a minority of infected individuals develop clinical symptoms or diseases. The presence of H. pylori virulence factors, such as CagA and VacA, has been associated with disease development, but assessment of virulence factor presence requires gastric biopsies. Here, we evaluate the H. pylori recomLine test for risk stratifica...
Source: Journal of Immunology Research - June 25, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research