IL-17 Affects the Progression, Metastasis, and Recurrence of Laryngeal Cancer via the Inhibition of Apoptosis through Activation of the PI3K/AKT/FAS/FASL Pathways.
Conclusions: In summary, these findings demonstrated for the first time the role of IL-17 as a tumor promoter and a prometastatic factor in LC and indicated that IL-17 may have an oncogenic role and serve as a potential prognostic biomarker and therapeutic target in LC. PMID: 33415169 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - January 10, 2021 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Circulating Monocytic Myeloid-Derived Suppressor Cells Are Elevated and Associated with Poor Prognosis in Acute Myeloid Leukemia.
We examined the frequencies of M-MDSCs identified for CD14+HLA-DRlow/- by flow cytometry in the peripheral circulating blood of 109 newly diagnosed adult patients with AML and 30 healthy controls (HC). Then, we, respectively, validated the clinic significance of circulating M-MDSCs on the relevance of spectral features for diagnostic stratification, induction therapy response, treatment effect maintenance, and long-term survival in AML. Results: Circulating M-MDSC frequencies of AML were significantly higher than those of HC both in CD14+ monocytes (46.22% ± 2.95% vs. 1.07% ± 0.17%, p
Source: Journal of Immunology Research - January 10, 2021 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Identifying 4 Novel lncRNAs as Potential Biomarkers for Acute Rejection and Graft Loss of Renal Allograft.
This study was performed to identify novel long noncoding RNAs (lncRNAs) for diagnosing AR and predicting the risk of graft loss. The several microarray datasets with AR and nonrejection specimens of renal allograft downloaded from Gene Expression Omnibus database were analyzed to screen differentially expressed lncRNAs (DElncRNAs) and mRNAs (DEmRNAs). Univariate and multivariate Cox regression analyses were used to identify optimal prognosis-related DElncRNAs for constructing a risk score model. 39 common DElncRNAs and 185 common DEmRNAs were identified to construct a lncRNA-mRNA regulatory relationship network. DElncRNAs...
Source: Journal of Immunology Research - December 31, 2020 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Defects at the Posttranscriptional Level Account for the Low TCR ζ Chain Expression Detected in Gastric Cancer Independently of Caspase-3 Activity.
Defects at the Posttranscriptional Level Account for the Low TCRζ Chain Expression Detected in Gastric Cancer Independently of Caspase-3 Activity. J Immunol Res. 2020;2020:1039458 Authors: Aguinaga-Barrilero A, Castro-Sánchez P, Juárez I, Gutiérrez-Calvo A, Rodríguez-Pérez N, Lopez A, Gómez R, Martin-Villa JM Abstract Background: Reduced TCRζ chain surface has been reported in T cells from patients with different inflammatory conditions and cancer. However, the causes of this diminished expression in cancer remain elusive. Methods: T cell-enriched...
Source: Journal of Immunology Research - December 30, 2020 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Stay Home: Role of Physical Exercise Training in Elderly Individuals' Ability to Face the COVID-19 Infection.
Authors: Abdelbasset WK Abstract Recently, the novel coronavirus epidemic occurred in China and spread worldwide to become a global pandemic. COVID-19 is a fatal viral infection causing death, particularly in aged individuals, due to impaired immunity. To date, no intervention is available to prevent COVID-19 and its manifestations. Physical exercise training generally has health benefits, and it assists in the prevention of several chronic diseases. Therefore, this review is aimed at exploring the role of physical exercise training in the face of COVID-19 in older adults and elderly individuals. From this point of...
Source: Journal of Immunology Research - December 30, 2020 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Lycium barbarum Polysaccharides Promote Maturity of Murine Dendritic Cells through Toll-Like Receptor 4-Erk1/2-Blimp1 Signaling Pathway.
In conclusion, our results indicate that LBP can induce maturation of DCs through the TLR4-Erk1/2-Blimp1 signal pathway instead of the JNK/p38-Blimp1 pathway. Our findings may provide a novel evidence for understanding the molecular mechanisms of LBP on activating murine DCs. PMID: 33344654 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - December 23, 2020 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Deciphering Antitumor Mechanism of Pien Tze Huang in Mice of Hepatocellular Carcinoma Based on Proteomics.
In this study, HCC xenograft Balb/c mice were treated with PZH; then, proteomics detection and Ingenuity Pathway Analysis (IPA) were used to analyze the differentiated phosphorylated proteins in tumor tissues. The results indicated that PZH could inhibit tumor weight by 50.76%. Eighty-four upregulated and 11 downregulated phosphorylated proteins were identified in PZH-treated mice. Twenty signaling pathways were associated with inflammation (including the IL-6 and TNFR1/2 pathways), cancer growth (including the p53 and FAK pathways), and the cell cycle (including the G2/M and G1/S checkpoint regulation pathways). Moreover,...
Source: Journal of Immunology Research - December 23, 2020 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Nuclear Alarmin Cytokines in Inflammation.
Authors: Jiang L, Shao Y, Tian Y, Ouyang C, Wang X Abstract Pathogen-associated molecular patterns (PAMPs) are some nonspecific and highly conserved molecular structures of exogenous specific microbial pathogens, whose products can be recognized by pattern recognition receptor (PRR) on innate immune cells and induce an inflammatory response. Under physiological stress, activated or damaged cells might release some endogenous proteins that can also bind to PRR and cause a harmful aseptic inflammatory response. These endogenous proteins were named damage-associated molecular patterns (DAMPs) or alarmins. Indeed, alar...
Source: Journal of Immunology Research - December 23, 2020 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Anemoside B4 Protects against Acute Lung Injury by Attenuating Inflammation through Blocking NLRP3 Inflammasome Activation and TLR4 Dimerization.
In this study, we explored the potential mechanisms and anti-inflammatory activity of B4 both in vitro and in vivo. The results indicated that B4 suppressed the expression of iNOS, COX-2, NLRP3, caspase-1, and IL-1β. The ELISA assay results showed that B4 significantly restrained the release of inflammatory cytokines like TNF-α, IL-6, and IL-1β in macrophage cells. In addition, B4 rescued mitochondrial membrane potential (MMP) loss in (lipopolysaccharide) LPS plus ATP stimulated macrophage cells. Co-IP and molecular docking results illustrated that B4 disrupted the dimerization of TLR4. For in vivo results,...
Source: Journal of Immunology Research - December 23, 2020 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Association of Neutrophil-Lymphocyte Ratio and the Presence of Neonatal Sepsis.
Authors: Li T, Dong G, Zhang M, Xu Z, Hu Y, Xie B, Wang Y, Xu B Abstract The neutrophil-lymphocyte ratio (NLR) is an emerging risk factor of sepsis that is receiving increasing attention. However, the relationship between NLR and the presence of sepsis in neonates is poorly studied. Here, we retrospectively recruited 1480 neonates and collected and analyzed relevant clinical and laboratory data. According to the International Pediatric Sepsis Consensus, 737 neonates were diagnosed with sepsis, and 555 neonates were suspected for having infection. Neonates with hyperbilirubinemia (n = 188) served as controls. Neonat...
Source: Journal of Immunology Research - December 23, 2020 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Leishmania mexicana: Novel Insights of Immune Modulation through Amastigote Exosomes.
Authors: Soto-Serna LE, Diupotex M, Zamora-Chimal J, Ruiz-Remigio A, Delgado-Domínguez J, Cervantes-Sarabia RB, Méndez-Bernal A, Escalona-Montaño AR, Aguirre-García MM, Becker I Abstract Exosomes are extracellular microvesicles of endosomal origin (multivesicular bodies, MVBs) constitutively released by eukaryotic cells by fusion of MVBs to the plasma membrane. The exosomes from Leishmania parasites contain an array of parasite molecules such as virulence factors and survival messengers, capable of modulating the host immune response and thereby favoring the infection of the host. We her...
Source: Journal of Immunology Research - December 23, 2020 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Human Bone Marrow Mesenchymal Stem/Stromal Cells Exposed to an Inflammatory Environment Increase the Expression of ICAM-1 and Release Microvesicles Enriched in This Adhesive Molecule: Analysis of the Participation of TNF- α and IFN-γ.
Human Bone Marrow Mesenchymal Stem/Stromal Cells Exposed to an Inflammatory Environment Increase the Expression of ICAM-1 and Release Microvesicles Enriched in This Adhesive Molecule: Analysis of the Participation of TNF-α and IFN-γ. J Immunol Res. 2020;2020:8839625 Authors: Montesinos JJ, López-García L, Cortés-Morales VA, Arriaga-Pizano L, Valle-Ríos R, Fajardo-Orduña GR, Castro-Manrreza ME Abstract Bone marrow mesenchymal stem/stromal cells (BM-MSCs) have immunoregulatory capacity; therefore, they have been used in different clinical protocols in which ...
Source: Journal of Immunology Research - December 20, 2020 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Increased Circulating Th1 and Tfh1 Cell Numbers Are Associated with Disease Activity in Glucocorticoid-Treated Patients with IgG4-Related Disease.
Conclusion: Increased circulating Th1 and Tfh1 subsets are related to elevated serum IgG4 levels in active IgG4-RD patients during glucocorticoid treatment, which may play an important role in the course of IgG4-RD disease, and could be potential biomarkers for monitoring disease activity of IgG4-RD. PMID: 33313326 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - December 15, 2020 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Increased Frequencies of Switched Memory B Cells and Plasmablasts in Peripheral Blood from Patients with ANCA-Associated Vasculitis.
Authors: Elmér E, Smargianaki S, Pettersson Å, Skattum L, Ohlsson S, Hellmark T, Johansson ÅCM Abstract B cells are thought to play a central role in the pathogenesis of antineutrophil cytoplasmic antibody- (ANCA-) associated vasculitis (AAV). ANCAs have been proposed to cause vasculitis by activating primed neutrophils to damage small blood vessels. We studied a cohort of AAV patients of which a majority were in remission and diagnosed with granulomatosis with polyangiitis (GPA). Using flow cytometry, the frequencies of CD19+ B cells and subsets in peripheral blood from 106 patients with AAV and...
Source: Journal of Immunology Research - December 15, 2020 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

M2 Macrophages Mediate the Resistance of Gastric Adenocarcinoma Cells to 5-Fluorouracil through the Expression of Integrin β3, Focal Adhesion Kinase, and Cofilin.
In this study, we investigated the role of alternatively activated macrophages in the resistance of AGS gastric cancer cells to fluorouracil. THP-1 cells were polarized using recombinant human IL-4, then were cocultured with AGS cells treated with fluorouracil. Cell viability, Western blot, immunofluorescence, and cell invasion were performed for this investigation. Our results demonstrated that polarized macrophages initiated the survival of treated AGS cells and induced the resistance in AGS by upregulating the expression of integrin β3, focal adhesion protein (FAK), and cofilin proteins. These results reveal that i...
Source: Journal of Immunology Research - December 13, 2020 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Predictors of Poor Outcome of Anti-MDA5-Associated Rapidly Progressive Interstitial Lung Disease in a Chinese Cohort with Dermatomyositis.
Authors: Li Y, Li Y, Wu J, Miao M, Gao X, Cai W, Shao M, Zhang X, Xu Y, Cong L, He J, Sun X Abstract Objective: Antimelanoma differentiation-associated protein 5 (anti-MDA5) autoantibody has been reported in dermatomyositis (DM) to be associated with rapidly progressive interstitial lung disease (RP-ILD). Our study is aimed at determining the clinical characteristics and prognostic factors underpinning anti-MDA5-associated RP-ILD. Methods: Patients with anti-MDA5-associated DM (aMDA5-DM) were identified at the Peking University People's Hospital. The presence of anti-MDA5 antibody was determined by immunoblotti...
Source: Journal of Immunology Research - December 13, 2020 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Clinical Features and Risk Factors of Active Tuberculosis in Patients with Beh çet's Disease.
Clinical Features and Risk Factors of Active Tuberculosis in Patients with Behçet's Disease. J Immunol Res. 2020;2020:2528676 Authors: Liu Y, Zhang L, Zhou Z, Sun L, Zhou B, Liu X, Zheng W Abstract To investigate the clinical features and potential risk factors of active tuberculosis (ATB) in Behçet's disease (BD), we conducted a case-control study on hospitalized BD patients in our institute from 2010 to 2019. BD patients with ATB were enrolled as the case group. The control group was selected by random number sampling from the remaining BD patients, including those with latent tuberculo...
Source: Journal of Immunology Research - December 13, 2020 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Methylprednisolone Pulse Therapy or Additional IVIG for Patients with IVIG-Resistant Kawasaki Disease.
Authors: Wang Z, Chen F, Wang Y, Li W, Xie X, Liu P, Zhang X, Zhang L, Huang P Abstract There have been no robust data from clinical trials to guide the clinician in the choice of therapeutic agents for the child with intravenous immunoglobulin (IVIG) resistance. The treatment regimen for IVIG-resistant patients varies between institutions, and the best option has not yet been established. Therefore, in this trial, a total of 955 patients with Kawasaki disease (KD) were selected and were initially treated with IVIG (2 g/kg), of whom 80 (8.38%) assessed as IVIG resistant were randomly divided into two groups:...
Source: Journal of Immunology Research - December 13, 2020 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Potential Therapeutic Role of Purinergic Receptors in Cardiovascular Disease Mediated by SARS-CoV-2.
Authors: Dos Anjos F, Simões JLB, Assmann CE, Carvalho FB, Bagatini MD Abstract Novel coronavirus disease 2019 (COVID-19) causes pulmonary and cardiovascular disorders and has become a worldwide emergency. Myocardial injury can be caused by direct or indirect damage, particularly mediated by a cytokine storm, a disordered immune response that can cause myocarditis, abnormal coagulation, arrhythmia, acute coronary syndrome, and myocardial infarction. The present review focuses on the mechanisms of this viral infection, cardiac biomarkers, consequences, and the possible therapeutic role of purinergic and adeno...
Source: Journal of Immunology Research - December 13, 2020 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Effect of Subantimicrobial Dose Doxycycline Treatment on Gingival Crevicular Fluid Levels of MMP-9 and MMP-13 in Periodontitis Stage 2, Grade B in Subjects with Type 2 Diabetes Mellitus.
Authors: Attia MS, Alblowi JA Abstract The aim of this study was to investigate the effect of using subantimicrobial dose doxycycline as an adjunct in periodontitis stage 2, grade B in subjects with type 2 diabetes mellitus. A total of thirty patients were divided into the following two groups with reference to periodontitis, type 2 diabetes mellitus, and administration of the doxycycline drug: Group I: patients with periodontitis stage 2, grade B and type 2 diabetes mellitus who received SRP only. Group II: patients with periodontitis stage 2, grade B and type 2 diabetes mellitus who received SRP and doxycycline 2...
Source: Journal of Immunology Research - December 11, 2020 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

The Function of T Follicular Helper Cells in the Autoimmune Liver Diseases.
Authors: Li L, Xu P, Zhou Q, Xu J Abstract T follicular helper (TFH) cells are recognized as a subtype of T cells that are involved in the germinal center formation and B cell development. When dysregulated, TFH cells may represent an important mechanism that contributes to a heightened humoral response and autoantibody production in autoimmune liver diseases (AILDs). TFH cells participate in the immune response associated with AILDs by expressing surface receptors such as programmed cell death protein-1, C-X-C motif chemokine receptor 5, and inducible T cell costimulators, as well as cytokines such as interleukin-...
Source: Journal of Immunology Research - December 11, 2020 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Th1/Th2 Cells and Associated Cytokines in Acute Hepatitis E and Related Acute Liver Failure.
Authors: Wu J, Guo Y, Lu X, Huang F, Lv F, Wei D, Shang A, Yang J, Pan Q, Jiang B, Yu J, Cao H, Li L Abstract Background and Aims: The involvement of cellular immunity in the development of hepatitis E virus (HEV) infection is rare. We aimed to study the roles of viral load and Th cell responses in acute hepatitis E (AHE) and HEV-related acute liver failure (HEV-ALF). Methods: We evaluated viral load and Th1/Th2 cytokine levels in 34 patients with HEV infection, including 17 each with AHE or HEV-ALF. Seventeen healthy controls (HCs) were also included who were negative for anti-HEV IgM and IgG. Results: The...
Source: Journal of Immunology Research - December 11, 2020 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Effect of SIS3 on Extracellular Matrix Remodeling and Repair in a Lipopolysaccharide-Induced ARDS Rat Model.
In this study, a rat model was established to mimic ARDS via intratracheal instillation of lipopolysaccharide (LPS). A selective inhibitor of Smad3 (SIS3) was intraperitoneally injected into the disease model, while phosphate-buffered saline (PBS) was used in the control group. Animal tissues were then evaluated using histological analysis, immunohistochemistry, RT-qPCR, ELISA, and western blotting. LPS was found to stimulate the expression of RAGE, TGF-β1, MMP2, and MMP9 in the rat model. Moreover, treatment with SIS3 was observed to reverse the expression of these molecules. In addition, pretreatment with SIS3 was s...
Source: Journal of Immunology Research - December 11, 2020 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Activating the Antitumor Immune Response in Non-Hodgkin Lymphoma Using Immune Checkpoint Inhibitors.
Authors: Joshi M, Ansell SM Abstract Non-Hodgkin lymphomas comprise a heterogenous group of disorders which differ in biology. Although response rates are high in some groups, relapsed disease can be difficult to treat, and newer approaches are needed for this patient population. It is increasingly apparent that the immune system plays a significant role in the propagation and survival of malignant cells. Immune checkpoint blocking agents augment cytotoxic activity of the adaptive and innate immune systems and enhance tumor cell killing. Anti-PD-1 and anti-CTLA-4 antibodies have been tested as both single agents an...
Source: Journal of Immunology Research - December 11, 2020 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Cells of the Innate and Adaptive Immune Systems in Kaposi's Sarcoma.
Authors: Ngalamika O, Munsaka S Abstract Kaposi's sarcoma (KS) is an angioproliferative malignancy whose associated etiologic agent is the Kaposi's sarcoma-associated herpesvirus (KSHV). KS is the most prevalent malignancy among HIV-infected individuals globally and is considered an AIDS-defining malignancy. The different forms of KS including HIV-associated KS, iatrogenic (immunosuppression-related) KS, and classical KS in elderly males suggest that immune cell dysregulation is among the key components in promoting KS development in KSHV-infected individuals. It is therefore expected that different cell types of t...
Source: Journal of Immunology Research - December 11, 2020 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Genes Induced by Panax Notoginseng in a Rodent Model of Ischemia-Reperfusion Injury.
In this study, middle cerebral artery occlusion (MCAO) was induced in rats with thrombi generated by thread and subsequently treated with PN. After that, staining with 2,3,5-triphenyltetrazolium chloride was employed to evaluate the infarcted area, and electron microscopy was used to assess ultrastructural changes of the neurovascular unit. RNA-Seq was performed to determine the differential expressed genes (DEGs) which were then verified by qPCR. In total, 817 DEGs were identified to be related to the therapeutic effect of PN on stroke recovery. Further analysis by Gene Oncology analysis and Kyoto Encyclopedia of Genes an...
Source: Journal of Immunology Research - December 11, 2020 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Cancer Vaccines: Toward the Next Breakthrough in Cancer Immunotherapy.
Authors: Igarashi Y, Sasada T Abstract Until now, three types of well-recognized cancer treatments have been developed, i.e., surgery, chemotherapy, and radiotherapy; these either remove or directly attack the cancer cells. These treatments can cure cancer at earlier stages but are frequently ineffective for treating cancer in the advanced or recurrent stages. Basic and clinical research on the tumor microenvironment, which consists of cancerous, stromal, and immune cells, demonstrates the critical role of antitumor immunity in cancer development and progression. Cancer immunotherapies have been proposed as the fou...
Source: Journal of Immunology Research - December 8, 2020 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Intranigral Administration of β-Sitosterol-β-D-Glucoside Elicits Neurotoxic A1 Astrocyte Reactivity and Chronic Neuroinflammation in the Rat Substantia Nigra.
Intranigral Administration of β-Sitosterol-β-D-Glucoside Elicits Neurotoxic A1 Astrocyte Reactivity and Chronic Neuroinflammation in the Rat Substantia Nigra. J Immunol Res. 2020;2020:5907591 Authors: Luna-Herrera C, Martínez-Dávila IA, Soto-Rojas LO, Flores-Martinez YM, Fernandez-Parrilla MA, Ayala-Davila J, León-Chavez BA, Soto-Rodriguez G, Blanco-Alvarez VM, Lopez-Salas FE, Gutierrez-Castillo ME, Gatica-Garcia B, Padilla-Viveros A, Bañuelos C, Reyes-Corona D, Espadas-Alvarez AJ, Garcés-Ramírez L, Hidalgo-Alegria O, De La Cruz-López F, Martinez-Fong ...
Source: Journal of Immunology Research - December 8, 2020 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Major Histocompatibility Complex Genes as Therapeutic Opportunity for Immune Cold Molecular Cancer Subtypes.
Authors: Karpiński P, Łaczmański Ł, Sąsiadek MM Abstract Current immunotherapies are effective only in a subset of patients, likely due to several factors including defects in tumor cell antigen presentation, decreased response to immune effectors, and molecular heterogeneity of cancers. Recent molecular classifications enable the categorization of many tumor types. However, deregulation of major histocompatibility complex (MHC) gene expression is poorly characterized in the context of molecular cancer subtypes. To suppress the confounding effect of immune infiltrates on expression patterns of immunoregulators...
Source: Journal of Immunology Research - December 8, 2020 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

The SIRT3 and SIRT6 Promote Prostate Cancer Progression by Inhibiting Necroptosis-Mediated Innate Immune Response.
Authors: Fu W, Li H, Fu H, Zhao S, Shi W, Sun M, Li Y Abstract The sirtuins (SIRTs), including seven family members, belong to class III histone deacetylase (HDAC) enzymes, which have been intensively investigated in cancers. Although the function of SIRTs in the cancer immunology is explored, SIRT-specific mechanisms regulating necroptosis-related innate immune response are not clear. In our present study, we found that both the mRNA and protein expression levels of SIRT3 and SIRT6 are significantly increased in the PCa tissues (HR, CI P = 3.30E - 03; HR, CI P = 2.35E - 08; and HR, CI P = 9.20E - 08) and were asso...
Source: Journal of Immunology Research - December 8, 2020 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

FOXP3 in Melanoma with Regression: Between Tumoral Expression and Regulatory T Cell Upregulation.
We present a retrospective cohort study including 52 cases of melanoma with regression. There were evaluated correlations of the most important prognostic factors (Breslow depth and mitotic index) with FOXP3 expression in tumor cells and with the presence of regulatory T cells and dendritic cells in the tumoral stroma. FOXP3 expression in tumor cells seems an independent factor of poor prognosis in melanoma, while regression areas are characterized by a high number of dendritic cells and a low number of regulatory T cells. FOXP3 is probably a useful therapeutical target in melanoma, since inhibition of FOXP3-positive tumor...
Source: Journal of Immunology Research - December 5, 2020 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Corrigendum to "Comparative Analysis of the Occurrence and Role of CX3CL1 (Fractalkine) and Its Receptor CX3CR1 in Hemophilic Arthropathy and Osteoarthritis".
Corrigendum to "Comparative Analysis of the Occurrence and Role of CX3CL1 (Fractalkine) and Its Receptor CX3CR1 in Hemophilic Arthropathy and Osteoarthritis". J Immunol Res. 2020;2020:7179283 Authors: Wojdasiewicz P, Poniatowski ŁA, Kotela A, Skoda M, Pyzlak M, Stangret A, Kotela I, Szukiewicz D Abstract [This corrects the article DOI: 10.1155/2020/2932696.]. PMID: 33274241 [PubMed] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - December 5, 2020 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Immunomodulatory Activity of the Marine Sponge, Haliclona (Soestella) sp. (Haplosclerida: Chalinidae), from Sri Lanka in Wistar Albino Rats: Immunosuppression and Th1-Skewed Cytokine Response.
Authors: Gunathilake V, Bertolino M, Bavestrello G, Udagama P Abstract Natural secondary metabolites of sponges of the genus Haliclona are associated with an array of biological activity with therapeutic usage. We investigated the immunopharmacological properties of a presumably novel marine sponge species from Sri Lanka, Haliclona (Soestella) sp. Sponge material was collected from southern Sri Lanka by scuba diving. Sponge identification was based on spicule and skeleton morphology using light microscopy. Selected in vivo and ex vivo tests investigated nonfunctional and functional immunomodulatory activity of the ...
Source: Journal of Immunology Research - December 5, 2020 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

The Role of Yersinia enterocolitica O:3 Lipopolysaccharide in Collagen-Induced Arthritis.
Authors: Kasperkiewicz K, Świerzko AS, Przybyła M, Szemraj J, Barski J, Skurnik M, Kałużyński A, Cedzyński M Abstract Yersinia enterocolitica O:3 is mentioned among the most common arthritogenic pathogens. Bacterial components (including lipopolysaccharide (LPS)) may persist in the joint after eradication of infection. Having an adjuvant activity, LPS may enhance production of anticollagen antibodies, involved in the pathogenesis of rheumatoid arthritis. Furthermore, its ability to activate complement contributes to the inflammation. The aim of this work was to investigate whether Yersinia LPS (coinjected wit...
Source: Journal of Immunology Research - December 5, 2020 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Persistent Activation of Innate Immunity in Patients with Primary Antibody Deficiencies.
In this study, we investigated by flow cytometry in different conditions (resting state, and after isolation and incubation, with and without stimuli) the expression pattern of several markers on PMN and monocytes, indicative of their maturation, capacity for chemotaxis, adhesion, opsonization, migration, and phagocytosis in 25 PAD patients, 12 healthy blood donors, and 4 septic patients. In this context, we also analyzed patients before and after the initiation of replacement treatment, as well as an untreated patient in different clinical conditions. Interestingly, we observed that PAD patients exhibit a chronic activati...
Source: Journal of Immunology Research - December 5, 2020 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Systemic Inflammation Response Index Predicts Survival Outcomes in Glioblastoma Multiforme Patients Treated with Standard Stupp Protocol.
Authors: Topkan E, Kucuk A, Ozdemir Y, Mertsoylu H, Besen AA, Sezen D, Bolukbasi Y, Pehlivan B, Selek U Abstract Objectives: We endeavored to retrospectively assess the prognostic merit of pretreatment systemic immune response index (SIRI) in glioblastoma multiforme (GBM) patients who underwent postoperative partial brain radiotherapy (RT) and concurrent plus adjuvant temozolomide (TMZ), namely, the Stupp protocol. Methods: The records of 181 newly diagnosed GBM patients who received the postoperative Stupp protocol were retrospectively analyzed. The SIRI value for each eligible patient was calculated by utiliz...
Source: Journal of Immunology Research - December 5, 2020 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Multiepitope Subunit Vaccine Design against COVID-19 Based on the Spike Protein of SARS-CoV-2: An In Silico Analysis.
In conclusion, our data supports the proposition that a multiepitope vaccine will provide protective immunity against COVID-19. However, further in vivo and in vitro experiments are needed to validate the immunogenicity and safety of the candidate vaccine. PMID: 33274246 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - December 5, 2020 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

SCUBE3 Is Likely a Susceptibility Gene for Systemic Lupus Erythematosus for Chinese Populations.
Conclusions: Our research revealed that variants in SCUBE3, which encode SCUBE3 as a TGF-β signaling activator, can be considered as a new genetic susceptibility factor for systemic lupus erythematosus. And the reduced mRNA expression of SCUBE3 was first reported in patients with SLE. PMID: 33274247 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - December 5, 2020 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Anti-Tyro3 IgG Associates with Disease Activity and Reduces Efferocytosis of Macrophages in New-Onset Systemic Lupus Erythematosus.
Authors: Zhou Z, Xu A, Teng J, Wang F, Tan Y, Liu H, Cheng X, Su Y, Shi H, Hu Q, Chi H, Li J, Hou J, Sun Y, Yang C, Ye J Abstract Background: Systemic lupus erythematosus (SLE) is a disease characterized by the production of a large number of autoantibodies. Defected phagocytosis of macrophage plays an important role in innate immunity in the pathogenesis of SLE. Tyro3 is a receptor responsible for the recognition of apoptotic cells during efferocytosis by macrophages. To investigate the role of Tyro3 receptor in macrophages' efferocytosis of apoptotic cells in SLE, we aimed to reveal the clinical relevance and imp...
Source: Journal of Immunology Research - November 24, 2020 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Some Common SNPs of the T-Cell Homeostasis-Related Genes Are Associated with Multiple Sclerosis, but Not with the Clinical Manifestations of the Disease, in the Polish Population.
Conclusion: Our results highlight the protective role of some of the T-cell homeostasis-related genetic variants in MS development, but not in its clinical manifestation. PMID: 33224992 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - November 24, 2020 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

After Treatment Decrease of Bone Marrow Tregs and Outcome in Younger Patients with Newly Diagnosed Acute Myeloid Leukemia.
Authors: Delia M, Carluccio P, Mestice A, Frappampina R, Albano F, Specchia G, Musto P Abstract An emerging body of evidence demonstrates that defects in antileukemic effector cells in patients with acute myeloid leukemia (AML) can contribute to the development and/or persistence of the disease. In particular, immune suppressive regulatory T cells (Tregs) may contribute to this defective antileukemic immune response, being recruited by bone marrow leukemic cells to evade immune surveillance. We evaluated Tregs (CD4+/CD45RA-/CD25high/CD127low), performing multiparametric flow cytometry on freshly collected bone marr...
Source: Journal of Immunology Research - November 21, 2020 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Design of Epitope-Based Peptide Vaccine against Pseudomonas aeruginosa Fructose Bisphosphate Aldolase Protein Using Immunoinformatics.
This study predicts an effective epitope-based vaccine against fructose bisphosphate aldolase (FBA) of Pseudomonas aeruginosa using immunoinformatics tools. The protein sequences were obtained from NCBI, and prediction tests were undertaken to analyze possible epitopes for B and T cells. Three B cell epitopes passed the antigenicity, accessibility, and hydrophilicity tests. Six MHC I epitopes were found to be promising, while four MHC II epitopes were found promising from the result set. Nineteen epitopes were shared between MHC I and II results. For the population coverage, the epitopes covered 95.62% worldwide excluding ...
Source: Journal of Immunology Research - November 21, 2020 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Prevotella Induces the Production of Th17 Cells in the Colon of Mice.
In conclusion, our data suggest that Prevotella induces the production of Th17 cells in the colon of mice, thus highlighting the potential role of Prevotella in training the intestinal immune system. PMID: 33204736 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - November 21, 2020 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Elevated IL-12, TNF- α, and TNF-α/IL-10 Ratios in Stored Plasmodium falciparum-Infected Whole Blood: Implications for Safe Haemotransfusion.
In conclusion, banking of P. falciparum-infected donor whole blood may lead to infusion of large quantities of inflammatory cytokines with potential adverse immunological response in recipients. PMID: 33195706 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - November 18, 2020 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Genetic Mutations of Tim-3 Ligand and Exhausted Tim-3+ CD8+ T Cells and Survival in Diffuse Large B Cell Lymphoma.
Authors: Zhang T, Ren T, Song Z, Zhao J, Jiao L, Zhang Z, He J, Liu X, Qiu L, Li L, Zhou S, Meng B, Zhai Q, Ren X, Qian Z, Wang X, Zhang H Abstract Tim-3 is a promising target for antitumor immunotherapy. A number of clinical trials are evaluating the efficacy of anti-Tim-3 therapies as a single agent or combinations in solid tumors and haematologic malignancies. However, there remains a considerable lack of data on Tim-3 signalling, especially the genetic characteristics and immune microenvironment, in diffuse large B cell lymphoma (DLBCL). Herein, we identified three genetic mutations in galectin-9, a major ligan...
Source: Journal of Immunology Research - November 14, 2020 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Tissue-Resident Type 2 Innate Lymphoid Cells Arrest Alveolarization in Bronchopulmonary Dysplasia.
This study identified a major destructive role of the ILC2s in BPD that could be attenuated as a therapeutic strategy. PMID: 33178840 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - November 14, 2020 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Current Clinical Applications and Future Perspectives of Immune Checkpoint Inhibitors in Non-Hodgkin Lymphoma.
Authors: Apostolidis J, Sayyed A, Darweesh M, Kaloyannidis P, Al Hashmi H Abstract Cancer cells escape immune recognition by exploiting the programmed cell-death protein 1 (PD-1)/programmed cell-death 1 ligand 1 (PD-L1) immune checkpoint axis. Immune checkpoint inhibitors that target PD-1/PD-L1 unleash the properties of effector T cells that are licensed to kill cancer cells. Immune checkpoint blockade has dramatically changed the treatment landscape of many cancers. Following the cancer paradigm, preliminary results of clinical trials in lymphoma have demonstrated that immune checkpoint inhibitors induce remarkabl...
Source: Journal of Immunology Research - November 14, 2020 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Corrigendum to "Advances in Immunology of Neglected Tropical Diseases: New Control Tools and Prospects for Disease Elimination".
Corrigendum to "Advances in Immunology of Neglected Tropical Diseases: New Control Tools and Prospects for Disease Elimination". J Immunol Res. 2020;2020:1948240 Authors: Figueiredo BC, Pinheiro CS, Marinho FV, Guerrero NA Abstract [This corrects the article DOI: 10.1155/2020/9361518.]. PMID: 33163538 [PubMed] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - November 11, 2020 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Innate Immune Effectors Play Essential Roles in Acute Respiratory Infection Caused by Klebsiella pneumoniae.
Authors: Liu D, Chen Z, Yuan Y, Jing H, Zou J, Zhang X, Zeng X, Zhang W, Zou Q, Zhang J Abstract Innate immune effectors constitute the first line of host defense against pathogens. However, the roles of these effectors are not clearly defined during Klebsiella pneumoniae (K. pneumoniae) respiratory infection. In the current study, we established an acute pneumonia model of K. pneumoniae respiratory infection in mice and confirmed that the injury was most severe 48 h post infection. Flow cytometric assay demonstrated that alveolar macrophages were the predominant cells in BALF before infection, and neutrophi...
Source: Journal of Immunology Research - November 11, 2020 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Association of NCF2, NCF4, and CYBA Gene Polymorphisms with Rheumatoid Arthritis in a Chinese Population.
Conclusions: In summary, NCF4 rs4821544 and rs729749 polymorphisms might contribute to RA susceptibility, while NCF2 and CYBA gene polymorphisms were not associated with RA susceptibility. PMID: 33145364 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - November 5, 2020 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research