The Question of HIV Vaccine: Why Is a Solution Not Yet Available?
J Immunol Res. 2024 Apr 8;2024:2147912. doi: 10.1155/2024/2147912. eCollection 2024.ABSTRACTEver since its discovery, human immunodeficiency virus type 1 (HIV-1) infection has remained a significant public health concern. The number of HIV-1 seropositive individuals currently stands at 40.1 million, yet definitive treatment for the virus is still unavailable on the market. Vaccination has proven to be a potent tool in combating infectious diseases, as evidenced by its success against other pathogens. However, despite ongoing efforts and research, the unique viral characteristics have prevented the development of an effecti...
Source: Journal of Immunology Research - April 17, 2024 Category: Allergy & Immunology Authors: Martina Libera Valeria Caputo Giulia Laterza Louiza Moudoud Alessio Soggiu Luigi Bonizzi Roberta A Diotti Source Type: research
Dendritic Cell-Based Immunotherapy: The Importance of Dendritic Cell Migration
J Immunol Res. 2024 Apr 8;2024:7827246. doi: 10.1155/2024/7827246. eCollection 2024.ABSTRACTDendritic cells (DCs) are specialized antigen-presenting cells that are crucial for maintaining self-tolerance, initiating immune responses against pathogens, and patrolling body compartments. Despite promising aspects, DC-based immunotherapy faces challenges that include limited availability, immune escape in tumors, immunosuppression in the tumor microenvironment, and the need for effective combination therapies. A further limitation in DC-based immunotherapy is the low population of migratory DC (around 5%-10%) that migrate to ly...
Source: Journal of Immunology Research - April 17, 2024 Category: Allergy & Immunology Authors: Min-Seon Song Ji-Hee Nam Kyung-Eun Noh Dae-Seog Lim Source Type: research
Circulating Immune Landscape Profiling in Psoriasis Vulgaris and Psoriatic Arthritis by Mass Cytometry
CONCLUSION: In the circulation of PsA patients, the TN and CD4+ TCM are characterized with more abundant CD28 and CD127, which effectively distinguished PsA from PsV. This may indicate that individuals undergoing PsV could be stratified at high risk of developing PsA based on the circulating levels of CD28 and CD127 on specific cell subsets.PMID:38590608 | PMC:PMC11001477 | DOI:10.1155/2024/9927964 (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - April 9, 2024 Category: Allergy & Immunology Authors: Xudong Sang Tian Gan Gai Ge Dan Li Youming Mei Chun Pan Siyu Long Bibo Xie Xiaobing Yu Zhiming Chen Hongsheng Wang Source Type: research
Identification of Specific Cell Surface Markers on Immune Cells of Squirrel Monkeys ( < em > Saimiri sciureus < /em > )
J Immunol Res. 2024 Mar 25;2024:8215195. doi: 10.1155/2024/8215195. eCollection 2024.ABSTRACTNonhuman primates are an important experimental model for the development of targeted biological therapeutics because of their immunological closeness to humans. However, there are very few antibody reagents relevant for delineating the different immune cell subsets based on nonhuman primate antigens directly or with cross-reactivity to those in humans. Here, we report specific expression of HLA-DR, PD-1, and CD123 on different circulating immune cell subsets in the peripheral blood that included T cells (CD3+), T cells subsets (CD...
Source: Journal of Immunology Research - April 3, 2024 Category: Allergy & Immunology Authors: Bharti P Nehete Ashley DeLise Pramod N Nehete Source Type: research
SerpinB3/B4 Abates Epithelial Cell-Derived CXCL8/IL-8 Expression in Chronic Rhinosinusitis with Nasal Polyps
CONCLUSION: SerpinB3/B4 expression is upregulated in nasal mucosa of CRSwNP patients. SerpinB3/B4 may play an anti-inflammatory role in CRSwNP by inhibiting the expression of epithelial cell-derived CXCL8/IL-8.PMID:38550710 | PMC:PMC10978078 | DOI:10.1155/2024/8553447 (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - March 29, 2024 Category: Allergy & Immunology Authors: Xiangting Bu Ming Wang Jing Yuan Jing Song Ge Luan Jiaqi Yu Yang Wang Ying Li Chengshuo Wang Luo Zhang Source Type: research
