Lymph Node-Targeting Nanovaccine through Antigen-CpG Self-Assembly Potentiates Cytotoxic T Cell Activation.
Authors: Xi X, Zhang L, Lu G, Gao X, Wei W, Ma G Abstract Therapeutic vaccines that arouse the cytotoxic T cell immune response to reject infected cells have been investigated extensively for treating disease. Due to the large amounts of resident antigen-presenting cells (APCs) and T cells in lymph nodes, great efforts have been made to explore the strategy of targeting lymph nodes directly with nanovaccines to activate T cells. However, these nanovaccines still have several problems, such as a low loading efficiency and compromised activity of antigens and adjuvants derived from traditional complicated preparation...
Source: Journal of Immunology Research - July 20, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Immunotherapy with Native Molecule rather than Hypoallergenic Variant of Pru p 3, the Major Peach Allergen, Shows Beneficial Effects in Mice.
Conclusion: Hypoallergenic folding variant of Pru p 3 is not likely an efficacious therapeutic component in SCIT of peach allergy. The lower efficacy of R/A Pru p 3 might be attributed to poor antigenicity and/or weak stability due to its unfolded conformation. PMID: 30009186 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - July 18, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Immune Responses to RNA Viruses.
Authors: Said EA, Diaz-Griffero F, Bonte D, Lamarre D, Al-Jabri AA PMID: 30009187 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - July 18, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Immunotherapy and Vaccine Development.
Authors: Leung C, Münz C, Riemer A PMID: 30009188 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - July 18, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Medical Plants and Immunological Regulation.
Authors: Xiao C, Guan Q, Tan Y, Hou L, Xie W PMID: 30009189 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - July 18, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

The Imbalance of FOXP3/GATA3 in Regulatory T Cells from the Peripheral Blood of Asthmatic Patients.
Conclusion: Treg cells decreased in asthmatic patients, with an impaired immunosupression function and a Th2-like phenotype, which may be due to overexpression of GATA3 and FOXP3, regulated by USP21 and PIM2, respectively. PMID: 30013989 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - July 18, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Poly-L-Arginine Induces Apoptosis of NCI-H292 Cells via ERK1/2 Signaling Pathway.
Conclusions. PLA can induce the apoptosis in NCI-H292 cells, and this process at least involved the ERK1/2 and mitochondrial pathway. The results could have some indications in revealing the apoptotic damage of the airway epithelial cells. Besides, inhibition of cationic protein-induced apoptotic death in airway epithelial cells could be considered as a potential target of anti-injury or antiremodeling in asthmatics. PMID: 30013990 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - July 18, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Immunological Mechanisms in Allergic Diseases and Allergen Tolerance: The Role of Treg Cells.
Authors: Calzada D, Baos S, Cremades-Jimeno L, Cárdaba B Abstract The immune system regulates itself to establish an appropriate immune response to potentially harmful pathogens while tolerating harmless environmental antigens and self-antigens. A central role in this balance is played by regulatory T cells (Tregs) through various ways of actions. By means of molecule secretion and cell-cell contact mechanisms, Tregs may have the capacity to modulate effector T cells and suppress the action of proinflammatory cytokines across a broad range of cell types. As a result, abnormal regulatory T cell function has b...
Source: Journal of Immunology Research - July 18, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

STAT5 and TET2 Cooperate to Regulate FOXP3-TSDR Demethylation in CD4+ T Cells of Patients with Colorectal Cancer.
In conclusion, we have demonstrated that excessive amounts of STAT5 may bind more TET2 to the FOXP3-TSDR and upregulate FOXP3 expression via DNA demethylation. Our study improved the mechanism of FOXP3-TSDR hypomethylation in tumor-infiltrating CD4+ T cells of CRC patients. PMID: 30013992 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - July 18, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

CD4+CD25highCD127low/-FoxP3+ Regulatory T Cell Subpopulations in the Bone Marrow and Peripheral Blood of Children with ALL: Brief Report.
Authors: Niedźwiecki M, Budziło O, Zieliński M, Adamkiewicz-Drożyńska E, Maciejka-Kembłowska L, Szczepański T, Trzonkowski P Abstract CD4+CD25highCD127low/-FoxP3+ regulatory T cells (Tregs) are currently under extensive investigation in childhood acute lymphoblastic leukemia (ALL) and in other human cancers. Usually, Treg cells maintain the immune cell homeostasis. This small subset of T cells has been, in fact, considered to be involved in the pathogenesis of autoimmune diseases and progression of acute and chronic leukemias. However, whether Treg dysregulation in CLL and ALL plays a key role or it rather r...
Source: Journal of Immunology Research - July 15, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Lower FOXP3 mRNA Expression in First-Trimester Decidual Tissue from Uncomplicated Term Pregnancies with a Male Fetus.
Authors: Kieffer TEC, Laskewitz A, Faas MM, Scherjon SA, Erwich JJHM, Gordijn SJ, Prins JR Abstract Pregnancies with a male fetus are associated with higher risks of pregnancy complications through maladaptation of the maternal immune system. The pathophysiology of this phenomenon is unknown. A possible pathway could be a fetal sex-dependent maternal immune response, since males have a Y chromosome encoding specific allogenic proteins, possibly contributing to a different response and higher complication risks. To analyze whether fetal sex affects mRNA expression of maternal immune genes in early pregnancy, real-ti...
Source: Journal of Immunology Research - July 15, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

PD-L1 Expression and CD8+ T Cell Infiltration Predict a Favorable Prognosis in Advanced Gastric Cancer.
Authors: Wang Y, Zhu C, Song W, Li J, Zhao G, Cao H Abstract Advanced gastric cancer (AGC) has high morbidity and mortality in East Asia, and it is urgent to explore new treatments to improve patient prognosis. Programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1) inhibitors have exhibited remarkable activity in clinical trials and were approved by the FDA for clinical therapy in several types of tumors. Here, we evaluated PD-L1 expression and T cell infiltration in AGC. Positive tumor PD-L1 expression was detected in 171 AGCs (33.60%) out of 509 AGCs. PD-L1 expression was positively correlated with CD8+ T ce...
Source: Journal of Immunology Research - July 15, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Hei-Gu-Teng Zhuifenghuoluo Granule Modulates IL-12 Signal Pathway to Inhibit the Inflammatory Response in Rheumatoid Arthritis.
This study aimed at exploring the mechanism of HGT on RA using the bioinformatics analysis with in vivo and in vitro experiment validation. The potential action mechanism was first investigated by bioinformatics analysis via Ingenuity Pathway Analysis (IPA) software. After that, we use experimental validation such as collagen-induced arthritis (CIA) mice model in vivo and U937 cell model in vitro. The bioinformatics results suggested that HGT may have anti-inflammatory characteristic on RA and IL-12 signaling pathway could be the potential key trigger. In vivo experiments demonstrated that HGT ameliorated the symptoms in C...
Source: Journal of Immunology Research - July 15, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

The Regulation of Inflammation by Innate and Adaptive Lymphocytes.
Authors: Cronkite DA, Strutt TM Abstract Inflammation plays an essential role in the control of pathogens and in shaping the ensuing adaptive immune responses. Traditionally, innate immunity has been described as a rapid response triggered through generic and nonspecific means that by definition lacks the ability to remember. Recently, it has become clear that some innate immune cells are epigenetically reprogrammed or "imprinted" by past experiences. These "trained" innate immune cells display altered inflammatory responses upon subsequent pathogen encounter. Remembrance of past pathogen encoun...
Source: Journal of Immunology Research - July 12, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Asymptomatic HIV People Present Different Profiles of sCD14, sRAGE, DNA Damage, and Vitamins, according to the Use of cART and CD4+ T Cell Restoration.
Authors: Tasca KI, Correa CR, Caleffi JT, Mendes MB, Gatto M, Manfio VM, de Camargo CC, Tavares FC, Biasin M, de Souza LDR Abstract We aimed to analyze markers of immune activation, inflammation, and oxidative stress in 92 asymptomatic HIV-infected patients according to the adequate (AR,>500 cells/mm3) or inadequate (IR,  nAR > LTNP > tAR > tIR. Higher levels of 8-isoprostane were observed in nIR. LTNP presented a higher retinol dosage than tAR and less genotoxic damage induced by oxidative stress than the other groups. We suggest that the therapy, despit...
Source: Journal of Immunology Research - July 12, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Adverse Immunologically Mediated Oral Mucosal Reactions to Systemic Medication: Lichenoid Tissue Reaction/Interface Dermatitis-Stomatitis, Autoimmune Vesiculobullous Disease, and IgE-Dependent and Immune Complex Reactions.
Authors: Khammissa RAG, Chandran R, Masilana A, Lemmer J, Feller L Abstract Drug-induced hypersensitivity immune reactions are exaggerated immunoinflammatory responses to allergenic components of the medications that occur in genetically susceptible subjects. The type of hypersensitivity immune response generated, whether antibody mediated or T cell mediated, or an immune complex reaction is determined by multiple factors, including the molecular characteristics of the allergen, the route of administration of the medication, the manner of presentation of the allergen by antigen-presenting cells to naïve T cell...
Source: Journal of Immunology Research - July 11, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

B Cell Activating Factor, Renal Allograft Antibody-Mediated Rejection, and Long-Term Outcome.
Authors: Xu H, He X, Xu R Abstract Antibody-mediated rejection (ABMR) of renal allograft lacks typical phenotypes and clinical manifestations, always resulting in delayed diagnosis and treatment. It has been considered to be an elemental factor influencing the improvement of the long-term outcome of renal allograft. The B cell activating factor (BAFF) signal plays a fundamental function in the process of antibody-mediated immune response. Data from recipients and the nonhuman primate ABMR model suggest that the BAFF signal participates in the ABMR of renal allograft, while there are objections. The challenges in th...
Source: Journal of Immunology Research - July 8, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Autoimmune Diseases and Their Manifestations on Oral Cavity: Diagnosis and Clinical Management.
Authors: Saccucci M, Di Carlo G, Bossù M, Giovarruscio F, Salucci A, Polimeni A Abstract Oral signs are frequently the first manifestation of autoimmune diseases. For this reason, dentists play an important role in the detection of emerging autoimmune pathologies. Indeed, an early diagnosis can play a decisive role in improving the quality of treatment strategies as well as quality of life. This can be obtained thanks to specific knowledge of oral manifestations of autoimmune diseases. This review is aimed at describing oral presentations, diagnosis, and treatment strategies for systemic lupus erythematosus,...
Source: Journal of Immunology Research - July 8, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

TRIF Regulates BIC/miR-155 via the ERK Signaling Pathway to Control the ox-LDL-Induced Macrophage Inflammatory Response.
Authors: Wu Y, Ye J, Guo R, Liang X, Yang L Abstract Toll/IL-1R-domain-containing adaptor-inducing IFN-β (TRIF) is an important adaptor for TLR3- and TLR4-mediated inflammatory signaling pathways. Recent studies have shown that TRIF plays a key role in vessel inflammation and atherosclerosis; however, the precise mechanisms are unclear. We investigated the mechanisms of the TRIF-regulated inflammatory response in RAW264.7 macrophages under oxidized low-density lipoprotein (ox-LDL) stimulation. Our data show that ox-LDL induces TRIF, miR-155, and BIC expression, activates the ERK1/2 and SOCS1-STAT3-NF-κB ...
Source: Journal of Immunology Research - July 8, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

LCK as a Potential Therapeutic Target for Acute Rejection after Kidney Transplantation: A Bioinformatics Clue.
Conclusion: LCK, via acting on T-cell receptor, might be a potential therapeutic target for AR after kidney transplantation. PMID: 29977931 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - July 8, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

MicroRNA in Sj ögren's Syndrome: Their Potential Roles in Pathogenesis and Diagnosis.
MicroRNA in Sjögren's Syndrome: Their Potential Roles in Pathogenesis and Diagnosis. J Immunol Res. 2018;2018:7510174 Authors: Reale M, D'Angelo C, Costantini E, Laus M, Moretti A, Croce A Abstract Sjögren's syndrome (SS) or sicca syndrome was described by Swedish ophthalmologist Sjögren in the year 1933 for the first time. The etiology of the SS is multifunctional and includes a combination of genetic predisposition and environmental as well as epigenetic factors. It is an autoimmune disease characterized by features of systemic autoimmunity, dysfunction, and inflammation in the exocrin...
Source: Journal of Immunology Research - July 8, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Expression of G αq Is Decreased in Lymphocytes from Primary Sjögren's Syndrome Patients and Related to Increased IL-17A Expression.
This study explored the role of Gαq in pSS. Gαq mRNA levels in peripheral blood mononuclear cells (PBMCs) from 39 patients and 26 healthy controls (HCs) were investigated using real-time PCR. IL-17A serum concentrations in 22 pSS patients and 23 HCs were tested by ELISA, and the clinical significance of Gαq was analyzed. The association of Gαq with interleukin-17A (IL-17A) expression was also analyzed in patients with pSS. We showed that Gαq expression in PBMCs from patients with pSS was significantly lower than that in PBMCs from HCs. Gαq expression level was closely associated with pSS...
Source: Journal of Immunology Research - July 8, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Microbiota Composition and the Integration of Exogenous and Endogenous Signals in Reactive Nasal Inflammation.
Authors: Salzano FA, Marino L, Salzano G, Botta RM, Cascone G, D'Agostino Fiorenza U, Selleri C, Casolaro V Abstract The prevalence of reactive nasal inflammatory conditions, for example, allergic rhinitis and chronic rhinosinusitis, is steadily increasing in parallel with significant environmental changes worldwide. Allergens and as yet undefined environmental agents may trigger these conditions via the involvement of host intrinsic factors, including the innate and adaptive immune system, the nasal epithelium, and the nasal nervous system. The critical role of the nasal microbiota in coordinating these components...
Source: Journal of Immunology Research - July 5, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Modulation of Inflammatory Reactions by Low-Dose Ionizing Radiation: Cytokine Release of Murine Endothelial Cells Is Dependent on Culture Conditions.
Conclusions: The study shows that LD-RT, also using very low radiation doses, has a clear immunomodulatory effect on EC as major participants and regulators of inflammation. PMID: 29967799 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - July 5, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Polysaccharides from Chinese Herbal Lycium barbarum Induced Systemic and Local Immune Responses in H22 Tumor-Bearing Mice.
Authors: Deng X, Luo S, Luo X, Hu M, Ma F, Wang Y, Lai X, Zhou L Abstract Lycium barbarum polysaccharide (LBP) is isolated from the fruit of Chinese herbal Lycium barbarum. Previous studies had demonstrated that LBP could inhibit tumor growth and enhance the immunity in mice. However, the effect of LBP on systemic and local immune responses in vivo, especially on phenotypic and functional changes of T cells, is still largely unknown. In the present study, we investigated the effects of LBP on systemic and local T cell-dependent antitumor immune responses in H22 tumor-bearing mice. The results showed that LBP could ...
Source: Journal of Immunology Research - July 5, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Modulation of Immune-Inflammatory Responses in Abdominal Aortic Aneurysm: Emerging Molecular Targets.
Authors: Li H, Bai S, Ao Q, Wang X, Tian X, Li X, Tong H, Hou W, Fan J Abstract Abdominal aortic aneurysm (AAA), a deadly vascular disease in human, is a chronic degenerative process of the abdominal aorta. In this process, inflammatory responses and immune system work efficiently by inflammatory cell attraction, proinflammatory factor secretion and subsequently MMP upregulation. Previous studies have demonstrated various inflammatory cell types in AAA of human and animals. The majority of cells, such as macrophages, CD4+ T cells, and B cells, play an important role in the diseased aortic wall through phenotypic mo...
Source: Journal of Immunology Research - July 5, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Macrophage Functions and Regulation: Roles in Diseases and Implications in Therapeutics.
Authors: Hu K, Jin Y, Chroneos Z, Han X, Liu H, Lin L PMID: 29967802 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - July 5, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Crotoxin Isolated from Crotalus durissus terrificus Venom Modulates the Functional Activity of Dendritic Cells via Formyl Peptide Receptors.
Authors: Freitas AP, Favoretto BC, Clissa PB, Sampaio SC, Faquim-Mauro EL Abstract The Crotalus durissus terrificus rattlesnake venom, its main toxin, crotoxin (CTX), and its crotapotin (CA) and phospholipase A2 (CB) subunits modulate the immune system. Formyl peptide receptors (FPRs) and lipoxin A4 (LXA4) are involved in CTX's effect on macrophages and neutrophils. Dendritic cells (DCs) are plasticity cells involved in the induction of adaptive immunity and tolerance maintenance. Therefore, we evaluated the effect of CTX, CA or CB on the maturation of DCs derived from murine bone marrow (BM). According to data, CT...
Source: Journal of Immunology Research - July 5, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

A Multiagent Alphavirus DNA Vaccine Delivered by Intramuscular Electroporation Elicits Robust and Durable Virus-Specific Immune Responses in Mice and Rabbits and Completely Protects Mice against Lethal Venezuelan, Western, and Eastern Equine Encephalitis Virus Aerosol Challenges.
Authors: Dupuy LC, Richards MJ, Livingston BD, Hannaman D, Schmaljohn CS Abstract There remains a need for vaccines that can safely and effectively protect against the biological threat agents Venezuelan (VEEV), western (WEEV), and eastern (EEEV) equine encephalitis virus. Previously, we demonstrated that a VEEV DNA vaccine that was optimized for increased antigen expression and delivered by intramuscular (IM) electroporation (EP) elicited robust and durable virus-specific antibody responses in multiple animal species and provided complete protection against VEEV aerosol challenge in mice and nonhuman primates. Her...
Source: Journal of Immunology Research - July 5, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Sample Aging Profoundly Reduces Monocyte Responses in Human Whole Blood Cultures.
Authors: Grievink HW, Moerland M Abstract Human whole blood cultures are widely used for the investigation of physiological pathways and drug effects in vitro. Detailed information on the effect of "sample aging" (the time span between blood collection and experimental start) on the experimental outcome is not readily available in the public domain. We studied the effect of sample aging on the ability of immune cells to respond to cell-specific immune triggers (LPS, PMA/ionomycin, and SEB). Sample aging at room temperature profoundly inhibited the LPS-induced monocytic cytokine release in minimally dilute...
Source: Journal of Immunology Research - July 5, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Risk of Immune-Related Pancreatitis in Patients with Solid Tumors Treated with Immune Checkpoint Inhibitors: Systematic Assessment with Meta-Analysis.
Authors: Su Q, Zhang XC, Zhang CG, Hou YL, Yao YX, Cao BW Abstract We performed a systematic review and meta-analysis to determine the risk of immune-related pancreatitis associated with the treatment by immune checkpoint inhibitors (ICIs) for solid tumors. Eligible studies were selected from multiple databases including phase II/III randomized controlled trials (RCTs) with ICIs in solid tumor patients. The data were analyzed with Stata version 12.0 software. After excluding ineligible studies, a total of 15 clinical trials were considered eligible for the meta-analysis, which included 9099 patients. Compared with ...
Source: Journal of Immunology Research - July 5, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Liver HLA-E Expression Is Associated with Severity of Liver Disease in Chronic Hepatitis C.
This study aimed to evaluate the expression of HLA-E in the liver and its association with the severity of liver disease in HCV patients. We performed a retrospective analysis of liver biopsies from 125 HCV patients and from 20 control subjects without liver disease. Liver biopsies were reviewed and classified according to severity of fibrosis and inflammatory activity. The pathologist assessed the magnitude of HLA-E expression in a semiquantitative way, attributing scores from 0 to 3. Immunohistochemistry showed positive for HLA-E in hepatocyte and Kupffer cells. The rate of HLA-E positivity in hepatocytes and Kupffer cel...
Source: Journal of Immunology Research - June 30, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Integrin α9 Suppresses Hepatocellular Carcinoma Metastasis by Rho GTPase Signaling.
Integrin α9 Suppresses Hepatocellular Carcinoma Metastasis by Rho GTPase Signaling. J Immunol Res. 2018;2018:4602570 Authors: Zhang YL, Xing X, Cai LB, Zhu L, Yang XM, Wang YH, Yang Q, Nie HZ, Zhang ZG, Li J, Zhang XL Abstract Integrin subunit alpha 9 (ITGA9) mediates cell-cell and cell-matrix adhesion, cell migration, and invasion through binding different kinds of extracellular matrix (ECM) components. However, its potential role and underlying molecular mechanisms remain unclear in hepatocellular carcinoma (HCC). Here, we found that ITGA9 expression was obviously decreased in patients with HCC...
Source: Journal of Immunology Research - June 30, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

NMO-IgG and AQP4 Peptide Can Induce Aggravation of EAMG and Immune-Mediated Muscle Weakness.
Authors: Mizrachi T, Brill L, Rabie M, Nevo Y, Fellig Y, Zur M, Karussis D, Abramsky O, Brenner T, Vaknin-Dembinsky A Abstract Neuromyelitis optica (NMO) and myasthenia gravis (MG) are autoimmune diseases mediated by autoantibodies against either aquaporin 4 (AQP4) or acetylcholine receptor (AChR), respectively. Recently, we and others have reported an increased prevalence of NMO in patients with MG. To verify whether coexisting autoimmune disease may exacerbate experimental autoimmune MG, we tested whether active immunization with AQP4 peptides or passive transfer of NMO-Ig can affect the severity of EAMG. Injecti...
Source: Journal of Immunology Research - June 30, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Immune Privilege and Eye-Derived T-Regulatory Cells.
Authors: Keino H, Horie S, Sugita S Abstract Certain cellular components of the eye, such as neural retina, are unable to regenerate and replicate after destructive inflammation. Ocular immune privilege provides the eye with immune protection against intraocular inflammation in order to minimize the risk to vision integrity. The eye and immune system use strategies to maintain the ocular immune privilege by regulating the innate and adaptive immune response, which includes immunological ignorance, peripheral tolerance to eye-derived antigens, and intraocular immunosuppressive microenvironment. In this review, we su...
Source: Journal of Immunology Research - June 12, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Suppression of Th17 Cell Response in the Alleviation of Dextran Sulfate Sodium-Induced Colitis by Ganoderma lucidum Polysaccharides.
Conclusions: GLP prevented inflammation, maintained intestinal homeostasis, and regulated the intestinal immunological barrier functions in mice with DSS-induced colitis. PMID: 29888292 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - June 12, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Toll-Like Receptors and RIG-I-Like Receptors Play Important Roles in Resisting Flavivirus.
Authors: Guo HY, Zhang XC, Jia RY Abstract Flaviviridae family is a class of single-stranded RNA virus, which is fatal to human and animals and mainly prevalent in subtropic and tropic countries. Even though people and animals are barraged with flavivirus infection every year, we have not invented either vaccines or antiviral for most flavivirus infections yet. Innate immunity is the first line of defense in resisting pathogen invasion, serving an important role in a resisting virus. Toll-like receptors (TLRs) and retinoic acid-inducible gene I- (RIG-I-) like receptors (RLRs) are crucial pattern recognition recepto...
Source: Journal of Immunology Research - June 12, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Meta-Analysis of the Changes of Peripheral Blood T Cell Subsets in Patients with Brucellosis.
Authors: Zheng R, Xie S, Niyazi S, Lu X, Sun L, Zhou Y, Zhang Y, Wang K Abstract Brucellosis is one of the most prevalent zoonotic diseases in the world, but its pathogenesis is not very clear. At present, it is thought that it may be related to the immunity of T cells. The conclusions of related studies are inconsistent, and its clinical significance is not explicit. We searched published articles in electronic databases up to December 2017 identified as relating to the clinical features of human brucellosis in China. Only eight studies had sufficient quality for data extraction. Meta-analysis showed a significant...
Source: Journal of Immunology Research - June 12, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Inhibition of IL-17 and IL-23 in Human Keratinocytes by the A3 Adenosine Receptor Agonist Piclidenoson.
In this study, we aimed to explore A3AR expression levels in psoriasis patients and its role in mediating the anti-inflammatory effect of piclidenoson in human keratinocyte cells. A3AR expression levels were evaluated in skin tissue and PBMCs derived from psoriasis patients and healthy subjects. Proliferation assay and the expression of signaling proteins were used to evaluate piclidenoson effect on human keratinocytes (HaCat). High A3AR expression levels were found in a skin biopsy and in PBMCs from psoriasis patients in comparison to healthy subjects. Piclidenoson inhibited the proliferation of HaCat cells through deregu...
Source: Journal of Immunology Research - June 5, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

How to Distinguish Patients with pSS among Individuals with Dryness without Invasive Diagnostic Studies.
In conclusion, invasive methods are pivotal in pSS diagnosis in this salivary gland biopsy. Chronic fatigue syndrome is more common in pSS patients and can be subjective distinguishing factor in the group of people with dryness. PMID: 29854827 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - June 4, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Acute Neuroinflammatory Response in the Substantia Nigra Pars Compacta of Rats after a Local Injection of Lipopolysaccharide.
Authors: Flores-Martinez YM, Fernandez-Parrilla MA, Ayala-Davila J, Reyes-Corona D, Blanco-Alvarez VM, Soto-Rojas LO, Luna-Herrera C, Gonzalez-Barrios JA, Leon-Chavez BA, Gutierrez-Castillo ME, Martínez-Dávila IA, Martinez-Fong D Abstract Models of Parkinson's disease with neurotoxins have shown that microglial activation does not evoke a typical inflammatory response in the substantia nigra, questioning whether neuroinflammation leads to neurodegeneration. To address this issue, the archetypal inflammatory stimulus, lipopolysaccharide (LPS), was injected into the rat substantia nigra. LPS induced fev...
Source: Journal of Immunology Research - June 4, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

MicroRNA Expression Profiling in Beh çet's Disease.
Conclusions: The combined analysis of deregulated miRNAs and BD transcriptome sheds light on some epigenetic aspects of BD identifying specific miRNAs, which may represent promising candidates as biomarkers and/or for the design of novel therapeutic strategies in BD. PMID: 29854829 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - June 4, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Deoxycholic Acid-Mediated Sphingosine-1-Phosphate Receptor 2 Signaling Exacerbates DSS-Induced Colitis through Promoting Cathepsin B Release.
In this study, we found that DCA could dose dependently upregulate S1PR2 expression. Meanwhile, DCA-induced NLRP3 inflammasome activation is at least partially achieved through stimulating extracellular regulated protein kinases (ERK) signaling pathway downstream of S1PR2 followed by promoting of lysosomal cathepsin B release. DCA enema significantly aggravated DSS-induced colitis in mice and S1PR2 inhibitor as well as inflammasome inhibition by cathepsin B antagonist substantially reducing the mature IL-1β production and alleviated colonic inflammation superimposed by DCA. Therefore, our findings suggest that S1PR2/E...
Source: Journal of Immunology Research - June 4, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

The Role of Monocyte/Macrophage and CXCR3 in Differentiation between Recurrent Hepatitis C and Acute Cellular Rejection Postliver Transplantation.
Authors: Gomaa AI, Ehsan NA, Elrefaei AA, Sultan MM, Elsabaawy MM Abstract Objective: Liver transplantation (LT) is the recommended treatment for patients with advanced liver disease and cirrhosis in all guidelines, mostly as a complication of HCV. The distinction between reinfection of the graft with HCV and acute cellular rejection (ACR) is essential because they are managed differently. Hepatic macrophages, which can either arise from circulating blood-derived monocytes (BDM) or from resident tissue Kupffer cells, are central in the pathogenesis of chronic liver injury. The aim of this work was to evaluate wheth...
Source: Journal of Immunology Research - June 4, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Viral Modulation of TLRs and Cytokines and the Related Immunotherapies for HPV-Associated Cancers.
Authors: Barros MR, de Oliveira THA, de Melo CML, Venuti A, de Freitas AC Abstract The modulation of the host innate immune system is a well-established carcinogenesis feature of several tumors, including human papillomavirus- (HPV-) related cancers. This virus is able to interrupt the initial events of the immune response, including the expression of Toll-like receptors (TLRs), cytokines, and inflammation. Both TLRs and cytokines play a central role in HPV recognition, cell maturation and differentiation as well as immune signalling. Therefore, the imbalance of this sensitive control of the immune response is a ke...
Source: Journal of Immunology Research - June 4, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Downregulation of iNOS, IL-1 β, and P2X7 Expression in Mast Cells via Activation of PAR4 Contributes to the Inhibition of Visceral Hyperalgesia in Rats.
Downregulation of iNOS, IL-1β, and P2X7 Expression in Mast Cells via Activation of PAR4 Contributes to the Inhibition of Visceral Hyperalgesia in Rats. J Immunol Res. 2018;2018:3256908 Authors: Hao Y, Niu H, An S, Wang M, Wang Z Abstract Protease-activated receptor 4 (PAR4) is implicated in the inhibition of visceral hyperalgesia. In the present study, the effects of PAR4 activation on visceral hypersensitivity and expression of inflammatory mediators, including interleukin-1β (IL-1β), P2RX7 purinergic receptor (P2X7), inducible nitric oxide synthase (iNOS), and tryptase, in mast cells (...
Source: Journal of Immunology Research - June 4, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Immune Response and Partial Protection against Heterologous Foot-and-Mouth Disease Virus Induced by Dendrimer Peptides in Cattle.
Authors: Soria I, Quattrocchi V, Langellotti C, Pérez-Filgueira M, Pega J, Gnazzo V, Romera S, Schammas J, Bucafusco D, Di Giacomo S, de la Torre BG, Andreu D, Sobrino F, Blanco E, Zamorano P Abstract Synthetic peptides mimicking protective B- and T-cell epitopes are good candidates for safer, more effective FMD vaccines. Nevertheless, previous studies of immunization with linear peptides showed that they failed to induce solid protection in cattle. Dendrimeric peptides displaying two or four copies of a peptide corresponding to the B-cell epitope VP1 [136-154] of type O FMDV (O/UKG/11/2001) linked through t...
Source: Journal of Immunology Research - June 4, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

March1 E3 Ubiquitin Ligase Modulates Features of Allergic Asthma in an Ovalbumin-Induced Mouse Model of Lung Inflammation.
Authors: Kishta OA, Sabourin A, Simon L, McGovern T, Raymond M, Galbas T, Majdoubi A, Ishido S, Martin JG, Thibodeau J Abstract Membrane-associated RING-CH-1 (March1) is a member of the March family of E3 ubiquitin ligases. March1 downregulates cell surface expression of MHC II and CD86 by targeting them to lysosomal degradation. Given the key roles of MHC class II and CD86 in T cell activation and to get further insights into the development of allergic inflammation, we asked whether March1 deficiency exacerbates or attenuates features of allergic asthma in mice. Herein, we used an acute model of allergy to compar...
Source: Journal of Immunology Research - June 4, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

The Involvement of MicroRNAs in Modulation of Innate and Adaptive Immunity in Systemic Lupus Erythematosus and Lupus Nephritis.
Authors: Honarpisheh M, Köhler P, von Rauchhaupt E, Lech M Abstract Noncoding RNAs (ncRNAs), including microRNAs (miRNAs), represent a family of RNA molecules that do not translate into protein. Nevertheless, they have the ability to regulate gene expression and play an essential role in immune cell differentiation and function. MicroRNAs were found to be differentially expressed in various tissues, and changes in their expression have been associated with several pathological processes. Yet, their roles in systemic lupus erythematosus (SLE) and lupus nephritis (LN) remain to be elucidated. Both SLE and LN are...
Source: Journal of Immunology Research - June 4, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Prevention of Cyclophosphamide-Induced Immunosuppression in Mice with the Antimicrobial Peptide Sublancin.
Authors: Wang S, Huang S, Ye Q, Zeng X, Yu H, Qi D, Qiao S Abstract Sublancin is a glycosylated antimicrobial peptide produced by Bacillus subtilis 168 with combined antibacterial and immunomodulatory activities. The purpose of this study was to evaluate the protective effects of sublancin on immunosuppression in cyclophosphamide-treated mice. In normal mice, the phagocytic activity of mouse peritoneal macrophages was significantly enhanced by oral administration of sublancin (1.0 mg/kg body weight) to BALB/c mice for 7 days (P
Source: Journal of Immunology Research - June 4, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research