Role of the Specialized Proresolving Mediator Resolvin D1 in Systemic Lupus Erythematosus: Preliminary Results.
Authors: Navarini L, Bisogno T, Margiotta DPE, Piccoli A, Angeletti S, Laudisio A, Ciccozzi M, Afeltra A, Maccarrone M Abstract Objective: Systemic lupus erythematosus (SLE) is an autoimmune systemic disease and its pathogenesis has not yet been completely clarified. Patients with SLE show a deranged lipid metabolism, which can contribute to the immunopathogenesis of the disease and to the accelerated atherosclerosis. Resolvin D1 (RvD1), a product of the metabolism of the omega-3 polyunsaturated fatty acid docosahexaenoic acid (DHA), acts as a specialized proresolving mediator which can contribute in restoring the ...
Source: Journal of Immunology Research - November 15, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Anti-ICOSL New Antigen Receptor Domains Inhibit T Cell Proliferation and Reduce the Development of Inflammation in the Collagen-Induced Mouse Model of Rheumatoid Arthritis.
In this study, we isolated specific anti-ICOSL new antigen receptor domains from a synthetic phage display library and demonstrated their ability to block the ICOS/ICOSL interaction and inhibit T cell proliferation. Anti-mouse ICOSL domains, considered here as surrogates for the use of anti-human ICOSL domains in patient therapy, were tested for efficacy in a collagen-induced mouse model of rheumatoid arthritis where they significantly decreased the inflammation of joints and delayed and reduced overall disease progression and severity. PMID: 30417018 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - November 13, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Essential Role of Zinc and Zinc Transporters in Myeloid Cell Function and Host Defense against Infection.
Authors: Sapkota M, Knoell DL Abstract Zinc is an essential micronutrient known to play a vital role in host defense against pathogens. Diets that are deficient in zinc lead to impaired immunity and delayed recovery from and worse outcomes following infection. Sustained insufficient zinc intake leads to dysregulation of the innate immune response and increases susceptibility to infection whereas zinc supplementation in at-risk populations has been shown to restore host defense and reduce pathogen-related morbidity and mortality. Upon infection, zinc deficiency leads to increased pathology due to imbalance in key si...
Source: Journal of Immunology Research - November 13, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

The Central Role of Inflammation Associated with Checkpoint Inhibitor Treatments.
Authors: Vajaitu C, Draghici CC, Solomon I, Lisievici CV, Popa AV, Lupu M, Caruntu C, Constantin MM, Voiculescu VM Abstract An important function of the immune system is its ability to differentiate between healthy cells in the organism and "foreign" cells, allowing the latest to be attacked and the first ones to be conserved. The most important molecules in this process are considered to be checkpoint inhibitors. This review is focused on the association between cancer and inflammation, underlying the mechanisms of action of monoclonal antibodies that are targeting checkpoint inhibitors: ipilimumab again...
Source: Journal of Immunology Research - November 13, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Differential Intestinal Mucosa Transcriptomic Biomarkers for Crohn's Disease and Ulcerative Colitis.
Authors: Dobre M, Milanesi E, Mănuc TE, Arsene DE, Ţieranu CG, Maj C, Becheanu G, Mănuc M Abstract Genetic research has shaped the inflammatory bowel disease (IBD) landscape identifying nearly two hundred risk loci. Nonetheless, the identified variants rendered only a partial success in providing criteria for the differential diagnosis between ulcerative colitis (UC) and Crohn's disease (CD). Transcript levels from affected intestinal mucosa may serve as tentative biomarkers for improving classification and diagnosis of IBD. The aim of our study was to identify gene expression profiles specific for UC and CD, in...
Source: Journal of Immunology Research - November 13, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Combination Therapy with EpCAM-CAR-NK-92 Cells and Regorafenib against Human Colorectal Cancer Models.
Authors: Zhang Q, Zhang H, Ding J, Liu H, Li H, Li H, Lu M, Miao Y, Li L, Zheng J Abstract Adoptive chimeric antigen receptor-modified T or NK cells (CAR-T or CAR-NK) offer new options for cancer treatment. CAR-T therapy has achieved encouraging breakthroughs in the treatment of hematological malignancies. However, their therapeutic efficacy against solid tumors is limited. New regimens, including combinations with chemical drugs, need to be studied to enhance the therapeutic efficacy of CAR-T or NK cells for solid tumors. An epithelial cell adhesion molecule- (EpCAM-) specific second-generation CAR was constructed...
Source: Journal of Immunology Research - November 11, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Preclinical and Clinical Therapeutic Strategies Affecting Tumor-Associated Macrophages in Hepatocellular Carcinoma.
Authors: Degroote H, Van Dierendonck A, Geerts A, Van Vlierberghe H, Devisscher L Abstract Hepatocellular carcinoma (HCC) most often develops in patients with underlying liver disease characterized by chronic nonresolving inflammation. Tumor-associated macrophages (TAMs) are one of the most abundant immune cell populations within the tumoral microenvironment. As key actors of cancer-related inflammation, they promote tumor growth by suppression of effective anticancer immunity, stimulation of angiogenesis, and tissue remodeling. Therefore, they have become an attractive and promising target for immunotherapy. The h...
Source: Journal of Immunology Research - November 11, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

OK-432 Acts as Adjuvant to Modulate T Helper 2 Inflammatory Responses in a Murine Model of Asthma.
Authors: Wu CJ, Tseng PH, Chan CC, Quon S, Chen LC, Kuo ML Abstract Enhanced type 2 helper T (Th2) cell responses to inhaled harmless allergens are strongly associated with the development of allergic diseases. Antigen formulated with an appropriate adjuvant can elicit suitable systemic immunity to protect individuals from disease. Although much has been learned about Th1-favored immunomodulation of OK-432, a streptococcal preparation with antineoplastic activity, little is known about its adjuvant effect for allergic diseases. Herein, we demonstrate that OK-432 acts as an adjuvant to favor a systemic Th1 polarizat...
Source: Journal of Immunology Research - November 9, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Autoimmunity and Otolaryngology Diseases.
Authors: Ralli M, Di Stadio A, De Virgilio A, Croce A, de Vincentiis M PMID: 30402505 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - November 9, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

TNIP1 in Autoimmune Diseases: Regulation of Toll-like Receptor Signaling.
Authors: Shamilov R, Aneskievich BJ Abstract TNIP1 protein is increasingly being recognized as a key repressor of inflammatory signaling and a potential factor in multiple autoimmune diseases. In addition to earlier foundational reports of TNIP1 SNPs in human autoimmune diseases and TNIP1 protein-protein interaction with receptor regulating proteins, more recent studies have identified new potential interaction partners and signaling pathways likely modulated by TNIP1. Subdomains within the TNIP1 protein as well as how they interact with ubiquitin have not only been mapped but inflammatory cell- and tissue-specific...
Source: Journal of Immunology Research - November 9, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Downregulation of Interleukin- (IL-) 17 through Enhanced Indoleamine 2,3-Dioxygenase (IDO) Induction by Curcumin: A Potential Mechanism of Tolerance towards Helicobacter pylori.
Authors: Larussa T, Gervasi S, Liparoti R, Suraci E, Marasco R, Imeneo M, Luzza F Abstract The anti-inflammatory and antimicrobial properties of curcumin suggest its use as an anti-Helicobacter pylori (H. pylori) agent, but mechanisms underlying its helpful activity are still not clear. Indoleamine 2,3-dioxygenase (IDO) promotes the effector T cell apoptosis by catalyzing the rate-limiting first step in tryptophan catabolism, and its high expression in H. pylori-infected human gastric mucosa attenuates Th1 and Th17 immune response. The aim of this study was to investigate the role of curcumin in modulating the expr...
Source: Journal of Immunology Research - November 9, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Complement System as a Target for Therapies to Control Liver Regeneration/Damage in Acute Liver Failure Induced by Viral Hepatitis.
Authors: Melgaço JG, Veloso CE, Pacheco-Moreira LF, Vitral CL, Pinto MA Abstract The complement system plays an important role in innate immunity inducing liver diseases as well as signaling immune cell activation in local inflammation regulating immunomodulatory effects such as liver damage and/or liver regeneration. Our aim is to evaluate the role of complement components in acute liver failure (ALF) caused by viral hepatitis, involving virus-induced ALF in human subjects using peripheral blood, samples of liver tissues, and ex vivo assays. Our findings displayed low levels of C3a in plasma samples with hi...
Source: Journal of Immunology Research - November 9, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Acer palmatum thumb. Ethanol Extract Alleviates Interleukin-6-Induced Barrier Dysfunction and Dextran Sodium Sulfate-Induced Colitis by Improving Intestinal Barrier Function and Reducing Inflammation.
Authors: Kim KY, Oh TW, Do HJ, Yang JH, Yang IJ, Jeon YH, Go YH, Ahn SC, Ma JY, Park KI Abstract Ulcerative colitis is one inflammatory bowel disease (IBD) and is caused by diverse factors, including the extent and duration of intestinal inflammation. We investigated the effect of Acer palmatum thumb. ethanol extract (KIOM-2015E) on the expression of tight junction proteins and the levels of inflammation in the cell model induced with interleukin-6- (IL-6-) and mouse model of dextran sodium sulfate (DSS) induced with acute colitis. KIOM-2015E (100 mg/kg) was orally administered once per day to BALB/C mice wi...
Source: Journal of Immunology Research - November 9, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Immunoinformatics Approach for Epitope-Based Peptide Vaccine Design and Active Site Prediction against Polyprotein of Emerging Oropouche Virus.
In this report, we identified both T-cell and B-cell epitopes of the most antigenic OROV polyprotein with the potential to induce both humoral and cell-mediated immunity. Eighteen highly antigenic and immunogenic CD8+ T-cell epitopes were identified, including three 100% conserved epitopes (TSSWGCEEY, CSMCGLIHY, and LAIDTGCLY) as the potential vaccine candidates. The selected epitopes showed 95.77% coverage for the mixed Brazilian population. The docking simulation ensured the binding interaction with high affinity. A total of five highly conserved and nontoxic linear B-cell epitopes "NQKIDLSQL," "HPLSTSQIGD...
Source: Journal of Immunology Research - November 9, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Lipid and Bile Acid Dysmetabolism in Crohn's Disease.
Authors: Uchiyama K, Kishi H, Komatsu W, Nagao M, Ohhira S, Kobashi G Abstract Crohn's disease is one of the systemic autoimmune diseases. It commonly affects the small intestine and colon but may involve any portion of the gastrointestinal tract from the mouth to the anus. The most affected area by Crohn's disease is the distal part of the small intestine, in which the bile acid molecules are most efficiently reabsorbed. Bile acids form mixed micelles together with fatty acids, which function as a transport vehicle to deliver fatty acids to the apical membrane of enterocytes for absorption. Therefore, if the termi...
Source: Journal of Immunology Research - November 9, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Reduced Activity of HDAC3 and Increased Acetylation of Histones H3 in Peripheral Blood Mononuclear Cells of Patients with Rheumatoid Arthritis.
Authors: Li Y, Zhou M, Lv X, Song L, Zhang D, He Y, Wang M, Zhao X, Yuan X, Shi G, Wang D Abstract Aberrant histone acetylation and deacetylation are increasingly thought to play important roles in the pathogenesis of rheumatoid arthritis (RA). However, limited data from studies about the activity of histone deacetylases (HDACs) and histone acetyltransferase (HAT) in RA are controversial. Those conflicting results may be caused by sample size, medication, and age- and sex-matched controls. The aim of this study is to investigate the expression and activity of class I HDACs (1-3.8) and their effects on histone acety...
Source: Journal of Immunology Research - November 9, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

The Application of Nanoparticle-Based Drug Delivery Systems in Checkpoint Blockade Cancer Immunotherapy.
In conclusion, the combination nanoparticle with checkpoint blockade cancer immunity is a promising direction that may fulfill the requirement of cancer treatment. PMID: 30406152 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - November 9, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

On the Dual Role of Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) in Human Malignancies.
Authors: Calinescu A, Turcu G, Nedelcu RI, Brinzea A, Hodorogea A, Antohe M, Diaconu C, Bleotu C, Pirici D, Jilaveanu LB, Ion DA, Badarau IA Abstract Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is a glycoprotein belonging to the carcinoembryonic antigen (CEA) family that is expressed on a wide variety of cells and holds a complex role in inflammation through its alternate splicing and generation of various isoforms, mediating intricate mechanisms of modulation and dysregulation. Initially regarded as a tumor suppressor as its expression shows considerable downregulation within the epithelia ...
Source: Journal of Immunology Research - November 9, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Function, Structure, and Transport Aspects of ZIP and ZnT Zinc Transporters in Immune Cells.
Authors: Bin BH, Seo J, Kim ST Abstract Zinc is an important trace metal in immune systems, and zinc transporters are involved in many immune responses. Recent advances have revealed the structural and biochemical bases for zinc transport across the cell membrane, with clinical implications for the regulation of zinc homeostasis in immune cells like dendritic cells, T cells, B cells, and mast cells. In this review, we discuss the function, structure, and transport aspects of two major mammalian zinc transporter types, importers and exporters. First, Zrt-/Irt-like proteins (ZIPs) mediate the zinc influx from the ext...
Source: Journal of Immunology Research - October 30, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Sevoflurane Inhibits the Th2 Response and NLRP3 Expression in Murine Allergic Airway Inflammation.
Conclusion: Taken together, our data showed that sevoflurane ameliorated allergic airway inflammation by inhibiting Th2 responses and NLRP3 expression. The NLRP3 independent of inflammasomes participated in the pathogenesis of allergic asthma in this model. PMID: 30363922 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - October 27, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Activation of PAR4 Upregulates p16 through Inhibition of DNMT1 and HDAC2 Expression via MAPK Signals in Esophageal Squamous Cell Carcinoma Cells.
In this study, we explored the relationship between PAR4 activation and the expression of p16, and elucidated the underlying mechanisms in PAR4 inducing the tumor suppressor role in ESCC. ESCC cell lines (EC109 and TE-1) were treated with PAR4-activating peptide (PAR4-AP). Immunohistochemistry for DNA methyltransferase 1 (DNMT1) and histone deacetylase 2 (HDAC2) was performed in 26 cases of ESCC tissues. We found that DNMT1 and HDAC2 immunoreactivities in ESCC were significantly higher than those in adjacent noncancerous tissues. PAR4 activation could suppress DNMT1 and HDAC2, as well as increase p16 expressions, whereas s...
Source: Journal of Immunology Research - October 27, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Murine DX5+NKT Cells Display Their Cytotoxic and Proapoptotic Potentials against Colitis-Inducing CD4+CD62Lhigh T Cells through Fas Ligand.
Conclusion: Collectively, these data confirmed that DX5+NKT cells inhibit proliferation of colitis-inducing CD4+CD62Lhigh cells by induction of apoptosis. Furthermore, DX5+NKT cells likely mediate their cytotoxic and proapoptotic potentials via FasL, confirming recent reports about iNKT cells. Further studies will be necessary to evaluate the therapeutical potential of these immunoregulatory cells in patients with colitis. PMID: 30364054 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - October 27, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Potential Antinociceptive Effects of Chinese Propolis and Identification on Its Active Compounds.
Authors: Sun L, Liao L, Wang B Abstract Propolis is an important bee product which has been applied to the treatment of several diseases. The aim of this study was to understand the material basis of Chinese propolis on pain relief; different Chinese propolis fractions (40W, 40E, 70E, and 95E raw propolis extracted followed by 40%, 70%, or 95% ethanol) were prepared, and their antinociceptive effects were evaluated. By analyzing using UPLC-Q-TOF-MS, we showed that 40W was rich in phenolic acids, like caffeic acid, while 40E, 70E, and 95E have relatively high levels in flavonoids, like galangin, pinocembrin, and chr...
Source: Journal of Immunology Research - October 26, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Update on Vertigo in Autoimmune Disorders, from Diagnosis to Treatment.
Authors: Girasoli L, Cazzador D, Padoan R, Nardello E, Felicetti M, Zanoletti E, Schiavon F, Bovo R Abstract The prevalence of autoimmune diseases has been increasing over the last 20 years. The clinical presentation of this large and heterogeneous group of disorders depends on whether the involvement is organ-specific or non-organ-specific. Dizziness, vertigo, and disequilibrium are common symptoms reported by patients with vestibulocochlear involvement. The association of vertigo and autoimmune diseases has been largely documented, suggesting that autoimmune disorders could be overrepresented in patients with ver...
Source: Journal of Immunology Research - October 26, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Combined Treatment with Zinc Aspartate and Intravenous Immunoglobulins (IVIGs) Ameliorates Experimental Autoimmune Encephalomyelitis (EAE).
Authors: Straubel D, Thielitz A, Reinhold A, Grüngreiff K, Reinhold D Abstract Intravenous immunoglobulins (IVIGs) are widely used in replacement therapy of primary and secondary immunodeficiency disorders and in approved autoimmune indications. In addition, IVIG application is used off-label for treatment of other autoimmune diseases, e.g., multiple sclerosis (MS), an inflammatory autoimmune disorder with a clear T cell-mediated immune pathogenesis. The trace element zinc is shown to play a regulatory role in the maintenance of immune functions. Changes of zinc homeostasis affect both the innate and the adapt...
Source: Journal of Immunology Research - October 26, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

The Fate of Allogeneic Pancreatic Islets following Intraportal Transplantation: Challenges and Solutions.
Authors: Li X, Meng Q, Zhang L Abstract Pancreatic islet transplantation as a therapeutic option for type 1 diabetes mellitus is gaining widespread attention because this approach can restore physiological insulin secretion, minimize the risk of hypoglycemic unawareness, and reduce the risk of death due to severe hypoglycemia. However, there are many obstacles contributing to the early mass loss of the islets and progressive islet loss in the late stages of clinical islet transplantation, including hypoxia injury, instant blood-mediated inflammatory reactions, inflammatory cytokines, immune rejection, metabolic exh...
Source: Journal of Immunology Research - October 23, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Differentiation and Function of T Cell Subsets in Infectious Diseases.
Authors: Liang Y, Chen X, Chen J, Liu F PMID: 30345317 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - October 23, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Biological Properties and the Role of IL-25 in Disease Pathogenesis.
Authors: Liu Y, Shao Z, Shangguan G, Bie Q, Zhang B Abstract The interleukin- (IL-) 17 superfamily, a T cell-derived cytokine, consists of 6 ligands (IL-17A-IL-17F) and 5 receptors (IL-17RA-IL-17RE). IL-17A, a prototype member of this family, is involved in the pathogenesis of allergies, autoimmune diseases, allograft transplantations, and malignancies. By contrast, IL-17B is reported to be closely related to certain diseases, particularly tumors such as breast cancer, gastric cancer, and pancreatic cancer. Recently, the biological function of IL-17E (also called IL-25) in disease, particularly airway diseases, has...
Source: Journal of Immunology Research - October 23, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Silicone-Induced Granuloma of Breast Implant Capsule (SIGBIC): Histopathology and Radiological Correlation.
The objective of this review is to correlate radiological findings of silicone-induced granuloma of breast implant capsule (SIGBIC) from breast MRI (BMRI) scans and complementary findings of ultrasound (US) and positron emission tomography (PET) scan, and its histology originated from surgical breast implant capsulectomy. To make this correlation possible, we divided SIGBIC into three radiological findings: (1) intracapsular SIGBIC, (2) SIGBIC with extracapsular extension, and (3) mixed SIGBIC associated with seroma. Our experience demonstrates histological-radiological correlation in SIGBIC diagnosis. Knowledge of these f...
Source: Journal of Immunology Research - October 19, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Beneficial Effects of Poplar Buds on Hyperglycemia, Dyslipidemia, Oxidative Stress, and Inflammation in Streptozotocin-Induced Type-2 Diabetes.
Authors: Peng S, Wei P, Lu Q, Liu R, Ding Y, Zhang J Abstract The effects of propolis on blood glucose regulation and the alleviation of various complications caused by diabetes have been widely studied. The main source of propolis in the northern temperate zone is poplar buds. However, there is limited research on the antidiabetic activity of poplar buds. In order to evaluate the effect of poplar buds on type-2 diabetes, crude extract and 50% fraction of poplar buds were used to feed streptozotocin-induced type-2 diabetic mice. The results showed that 50% fraction could increase insulin sensitivity and reduce insu...
Source: Journal of Immunology Research - October 16, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Cancer Immunotherapy: Priming the Host Immune Response with Live Attenuated Salmonella enterica.
Authors: Hernández-Luna MA, Luria-Pérez R Abstract In recent years, cancer immunotherapy has undergone great advances because of our understanding of the immune response and the mechanisms through which tumor cells evade it. A century after the first immunotherapy attempt based on bacterial products described by William Coley, the use of live attenuated bacterial vectors has become a promising alternative in the fight against cancer. This review describes the role of live attenuated Salmonella enterica as an oncolytic and immunotherapeutic agent, due to its high affinity for tumor tissue and its abili...
Source: Journal of Immunology Research - October 13, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Carbamazepine-Mediated Adverse Drug Reactions: CBZ-10,11-epoxide but Not Carbamazepine Induces the Alteration of Peptides Presented by HLA-B ∗15:02.
Carbamazepine-Mediated Adverse Drug Reactions: CBZ-10,11-epoxide but Not Carbamazepine Induces the Alteration of Peptides Presented by HLA-B∗15:02. J Immunol Res. 2018;2018:5086503 Authors: Simper GS, Hò GT, Celik AA, Huyton T, Kuhn J, Kunze-Schumacher H, Blasczyk R, Bade-Döding C Abstract Among patients treated with the anticonvulsive and psychotropic drug carbamazepine (CBZ), approximately 10% develop severe and life-threatening adverse drug reactions. These immunological conditions are resolved upon withdrawal of the medicament, suggesting that the drug does not manifest in the bo...
Source: Journal of Immunology Research - October 13, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Viral and Nonviral Engineering of Natural Killer Cells as Emerging Adoptive Cancer Immunotherapies.
Authors: Matosevic S Abstract Natural killer (NK) cells are powerful immune effectors whose antitumor activity is regulated through a sophisticated network of activating and inhibitory receptors. As effectors of cancer immunotherapy, NK cells are attractive as they do not attack healthy self-tissues nor do they induce T cell-driven inflammatory cytokine storm, enabling their use as allogeneic adoptive cellular therapies. Clinical responses to adoptive NK-based immunotherapy have been thwarted, however, by the profound immunosuppression induced by the tumor microenvironment, particularly severe in the context of sol...
Source: Journal of Immunology Research - October 13, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Evaluation of Soluble CD48 Levels in Patients with Allergic and Nonallergic Asthma in Relation to Markers of Type 2 and Non-Type 2 Immunity: An Observational Study.
Authors: Breuer O, Gangwar RS, Seaf M, Barhoum A, Kerem E, Levi-Schaffer F Abstract CD48 is a costimulatory receptor associated with human asthma. We aimed to assess the significance of the soluble form of CD48 (sCD48) in allergic and nonallergic asthma. Volunteer patients completed an asthma and allergy questionnaire, spirometry, methacholine challenge test, a common allergen skin prick test, and a complete blood count. sCD48, IgE, IL5, IL17A, IL33, and IFNγ were quantitated in serum by ELISA. Asthma was defined as positive methacholine challenge test or a 15% increase in FEV1 post bronchodilator in symptoma...
Source: Journal of Immunology Research - October 13, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Inflammatory-Driven Angiogenesis in Bone Augmentation with Bovine Hydroxyapatite, B-Tricalcium Phosphate, and Bioglasses: A Comparative Study.
Conclusion: We can conclude that bone substitutes as bovine bone and beta-tricalcium phosphate have significant increased angiogenesis (and subsequent improved osteogenesis) compared to the bioactive glass. In our study, significant angiogenesis is linked with a greater tissue formation, indicating that in bone engineering with the allografts we used, inflammation has more benefic effects, the catabolic action being exceeded by the tissue formation. PMID: 30298138 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - October 10, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Inflammation-Related Mechanisms in Chronic Kidney Disease Prediction, Progression, and Outcome.
Authors: Mihai S, Codrici E, Popescu ID, Enciu AM, Albulescu L, Necula LG, Mambet C, Anton G, Tanase C Abstract Persistent, low-grade inflammation is now considered a hallmark feature of chronic kidney disease (CKD), being involved in the development of all-cause mortality of these patients. Although substantial improvements have been made in clinical care, CKD remains a major public health burden, affecting 10-15% of the population, and its prevalence is constantly growing. Due to its insidious nature, CKD is rarely diagnosed in early stages, and once developed, its progression is unfortunately irreversible. There...
Source: Journal of Immunology Research - October 3, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Differences of Clonogenic Mesenchymal Stem Cells on Immunomodulation of Lymphocyte Subsets.
Authors: Martínez-Peinado P, Pascual-García S, Roche E, Sempere-Ortells JM Abstract Mesenchymal stem cells (MSC) are a widely used population in cell therapy for their ability to differentiate into distinct tissues and more lately, for their immunomodulatory properties. However, the use of heterogeneous populations could be responsible for the nondesired outcomes reflected in the literature. Here, we analyse the different capacities of five one-cell-derived MSC clones to exert their immunomodulation ex vivo. We assessed proliferation assays in cocultures of MSC clones and purified cluster of different...
Source: Journal of Immunology Research - October 3, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

OSU-T315 as an Interesting Lead Molecule for Novel B Cell-Specific Therapeutics.
In conclusion, OSU-T315 displays potency as B cell modulator, probably through a mechanism of action independent of ILK, and might serve as lead drug molecule for the development of novel B cell-selective drugs. PMID: 30276218 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - October 3, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Serum and Ectopic Endometrium from Women with Endometriosis Modulate Macrophage M1/M2 Polarization via the Smad2/Smad3 Pathway.
Conclusion: This study provides detailed evidence supporting alterations in M1 to M2 macrophage polarization that may contribute to the initiation as well as progression of endometriosis. PMID: 30276219 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - October 3, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Natural Killer Cells in Liver Disease and Hepatocellular Carcinoma and the NK Cell-Based Immunotherapy.
Authors: Liu P, Chen L, Zhang H Abstract Nature killer (NK) cells play a critical role in host innate and adaptive immune defense against viral infections and tumors. NK cells are enriched in liver hematopoietic cells with unique NK repertories and functions to safeguard liver cells against hepatitis virus infection or malignancy transformation. However, accumulating evidences were found that the NK cells were modulated by liver diseases and liver cancers including hepatocellular carcinoma (HCC) and showed impaired functions failing to activate the elimination of the viral-infected cells or tumor cells and were fur...
Source: Journal of Immunology Research - September 27, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Fetal and Maternal Outcomes of Planned Pregnancy in Patients with Systemic Lupus Erythematosus: A Retrospective Multicenter Study.
Conclusion: Planned pregnancy improved fetal and maternal outcomes, presenting as a lower rate of fetal loss, more favorable outcomes for preterm infants, and less severe disease flares during pregnancy. PMID: 30255104 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - September 27, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

The Role of Autoimmune Regulator (AIRE) in Peripheral Tolerance.
Authors: Zhao B, Chang L, Fu H, Sun G, Yang W Abstract Autoimmune regulator (AIRE), whose gene mutation is considered to be a causative factor of autoimmune polyglandular syndrome type 1 (APS1), is an important transcriptional regulator. Studies on the role of AIRE in the central immune system have demonstrated that AIRE can eliminate autoreactive T cells by regulating the expression of a series of tissue specific antigens promiscuously in medullary thymic epithelial cells (mTECs) and induce regulatory T cell (Treg) production to maintain central immune tolerance. However, the related research of AIRE in peripheral...
Source: Journal of Immunology Research - September 27, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Altered NKp30, NKp46, NKG2D, and DNAM-1 Expression on Circulating NK Cells Is Associated with Tumor Progression in Human Gastric Cancer.
Authors: Han B, Mao FY, Zhao YL, Lv YP, Teng YS, Duan M, Chen W, Cheng P, Wang TT, Liang ZY, Zhang JY, Liu YG, Guo G, Zou QM, Zhuang Y, Peng LS Abstract Natural killer (NK) cell activity is influenced by a complex integration of signaling pathways activated downstream of both activating and inhibitory surface receptors. The tumor microenvironment can suppress NK cell activity, and there is a great clinical interest in understanding whether modulating tumor-mediated NK cell suppression and/or boosting preexisting NK cell numbers in cancer patients is therapeutically viable. To this light, we characterized the surfac...
Source: Journal of Immunology Research - September 27, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

The Proportion of Regulatory T Cells in Patients with Systemic Lupus Erythematosus: A Meta-Analysis.
Authors: Zhang SX, Ma XW, Li YF, Lai NL, Huang ZH, Fan K, Wang CH, Li XF Abstract Background: Accumulating evidence indicates that a deficiency in or dysfunction of regulatory T cells (Tregs) is involved in the pathogenesis of systemic lupus erythematosus (SLE). As different markers have been used to identify Tregs, recent studies on the proportions of Tregs in SLE patients have generated controversial results. To clarify the status of Tregs in such patients, we determined the proportions of Tregs present during development of the disease, with special consideration of controversial cellular markers. Methods: W...
Source: Journal of Immunology Research - September 27, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Immune and Inflammatory-Mediated Disorders: From Bench to Bedside.
Authors: Reale M, Conti L, Velluto D PMID: 30255108 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - September 27, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Sex Differences in Correlation with Gene Expression Levels between Ifi200 Family Genes and Four Sets of Immune Disease-Relevant Genes.
Conclusions: Different genes in the Ifi200 family play different roles in sex difference among dissimilar pathways of these four gene groups. PMID: 30246031 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - September 26, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Two-Parametric Immunological Score Development for Assessing Renal Involvement and Disease Activity in Systemic Lupus Erythematosus.
Conclusions: Anti-dsDNA and anti-C1q antibodies are useful tools to identify disease activity and/or renal involvement in SLE patients. In addition, the combination of those antibodies in a two-parametric score might improve the clinical utility of those markers. PMID: 30246032 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - September 26, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Caveolin-1-Knockout Mouse as a Model of Inflammatory Diseases.
Authors: Codrici E, Albulescu L, Popescu ID, Mihai S, Enciu AM, Albulescu R, Tanase C, Hinescu ME Abstract Caveolin-1 (CAV1) is the scaffold protein of caveolae, which are minute invaginations of the cell membrane that are involved in endocytosis, cell signaling, and endothelial-mediated inflammation. CAV1 has also been reported to have a dual role as either a tumor suppressor or tumor promoter, depending on the type of cancer. Inflammation is an important player in tumor progression, but the role of caveolin-1 in generating an inflammatory milieu remains poorly characterized. We used a caveolin-1-knockout (CAV1-/-...
Source: Journal of Immunology Research - September 26, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Luteolin Induces Apoptosis and Autophagy in Mouse Macrophage ANA-1 Cells via the Bcl-2 Pathway.
In this study, mouse macrophage ANA-1 cells were incubated with different concentrations of luteolin. The viability of the cells was determined by an MTT assay, apoptosis was determined by flow cytometric analysis, the level of cell autophagy was observed by confocal microscopy, and the expression levels of apoptotic or autophagic and antiapoptotic or antiautophagic proteins were detected by Western blot analysis. The results showed that luteolin decreased the viability of ANA-1 cells and induced apoptosis and autophagy. Luteolin induced apoptosis accompanied by downregulation of the expression of Bcl-2 and upregulation of...
Source: Journal of Immunology Research - September 26, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Immunomodulatory Effects of 17 β-Estradiol on Epithelial Cells during Bacterial Infections.
Immunomodulatory Effects of 17β-Estradiol on Epithelial Cells during Bacterial Infections. J Immunol Res. 2018;2018:6098961 Authors: Medina-Estrada I, Alva-Murillo N, López-Meza JE, Ochoa-Zarzosa A Abstract The innate immune system can function under hormonal control. 17β-Estradiol (E2) is an important sexual hormone for the reproductive cycle of mammals, and it has immunomodulatory effects on epithelial cells, which are the first line of defense against incoming bacteria. E2 regulates various pathophysiological processes, including the response to infection in epithelial cells, and it...
Source: Journal of Immunology Research - September 26, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research