Immunological Changes in Peripheral Blood of Ankylosing Spondylitis Patients during Anti-TNF- < em > α < /em > Therapy and Their Correlations with Treatment Outcomes
This study is aimed at evaluating the longitudinal changes of circulating immune cells after anti-TNF-α therapy and their associations with treatment response in AS patients. Thirty-five AS patients receiving the treatment of anti-TNF-α therapy were included into this prospective observational study. The frequencies of immune cells including Th1, Th2, Th17, regulatory T cell (Treg), T follicular helper cell (Tfh), and regulatory B cell (Breg) in the peripheral blood were measured by flow cytometry at baseline and 4 time points after therapy. The difference in the circulating immune cells between responders and ...
Source: Journal of Immunology Research - October 25, 2021 Category: Allergy & Immunology Authors: Rongjuan Chen Hongyan Qian Xiaoqing Yuan Shiju Chen Yuan Liu Bin Wang Guixiu Shi Source Type: research

Lysophosphatidylcholine Offsets the Protective Effects of Bone Marrow Mesenchymal Stem Cells on Inflammatory Response and Oxidative Stress Injury of Retinal Endothelial Cells via TLR4/NF- < em > κ < /em > B Signaling
J Immunol Res. 2021 Oct 14;2021:2389029. doi: 10.1155/2021/2389029. eCollection 2021.ABSTRACTDiabetic retinopathy (DR), as a major cause of blindness worldwide, is one common complication of diabetes mellitus. Inflammatory response and oxidative stress injury of endothelial cells play significant roles in the pathogenesis of DR. The study is aimed at investigating the effects of lysophosphatidylcholine (LPC) on the dysfunction of high glucose- (HG-) treated human retinal microvascular endothelial cells (HRMECs) after being cocultured with bone marrow mesenchymal stem cells (BMSCs) and the underlying regulatory mechanism. C...
Source: Journal of Immunology Research - October 25, 2021 Category: Allergy & Immunology Authors: Haijun Zhao Yanhui He Source Type: research

Activation of FGD5-AS1 Promotes Progression of Cervical Cancer through Regulating BST2 to Inhibit Macrophage M1 Polarization
In conclusion, FGD5-AS1 induced M2 macrophage polarization via sponging miR-129-5p and modulating BST2, thus contributing to cervical cancer development. Our findings revealed FGD5-AS1/miR-129-5p/BST2 as a new potential target for cervical cancer.PMID:34692852 | PMC:PMC8536446 | DOI:10.1155/2021/5857214 (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - October 25, 2021 Category: Allergy & Immunology Authors: Guokun Liu Xuan Du Li Xiao Qing Zeng QianLing Liu Source Type: research

Impacts of Chemokine (C-X-C Motif) Receptor 2 C1208T Polymorphism on Cancer Susceptibility
CONCLUSIONS: The CXCR2 C1208T variation was associated with elevated risk of urinary, breast, and digestive cancer. However, the C1208T polymorphism was correlated with attenuated risk of lung cancer.PMID:34692853 | PMC:PMC8531794 | DOI:10.1155/2021/8727924 (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - October 25, 2021 Category: Allergy & Immunology Authors: Jing Zhou Hao Wu Quan-Xin Su Xiao-Kai Shi Bo-Wen Tang Cui-Ping Zhao Hai Wang Xiao-Ping Chen Source Type: research

Salivary and Serum Interleukin-10, C-Reactive Protein, Mean Platelet Volume, and CRP/MPV Ratio in the Diagnosis of Late-Onset Neonatal Sepsis in Full-Term Neonates
J Immunol Res. 2021 Oct 12;2021:4884537. doi: 10.1155/2021/4884537. eCollection 2021.ABSTRACTSalivary markers could serve as potential noninvasive markers in the diagnosis of neonatal infections. We aimed to investigate the diagnostic role of salivary and serum interleukin 10 (IL-10), C-reactive protein (CRP), mean platelet volume (MPV), and CRP/MPV ratio in the diagnosis of late-onset neonatal sepsis in full-term neonates. Seventy full-term neonates were enrolled in this prospective case-control study, 35 with late-onset neonatal sepsis, and 35 controls. Salivary IL-10, serum IL-10, and CRP concentrations were measured by...
Source: Journal of Immunology Research - October 22, 2021 Category: Allergy & Immunology Authors: Ahmed Omran Hazem Sobh Mohamed Osama Abdalla Sonya El-Sharkawy Ahmed R Rezk Abdelmoneim Khashana Source Type: research

Prognostic Role of Monocytic Myeloid-Derived Suppressor Cells in Advanced Non-Small-Cell Lung Cancer: Relation to Different Hematologic Indices
J Immunol Res. 2021 Oct 11;2021:3241150. doi: 10.1155/2021/3241150. eCollection 2021.ABSTRACTMETHODS: We recruited 40 cases of advanced NSCLC, stages III and IV, aged> 18-
Source: Journal of Immunology Research - October 21, 2021 Category: Allergy & Immunology Authors: Asmaa M Zahran Helal F Hetta Zeinab Albadry M Zahran Alaa Rashad Amal Rayan Dalia O Mohamed Zeinab Ahmed Abd Elhameed Salah M Khallaf Gaber El-Saber Batiha Yasir Waheed Khalid Muhammad Hanaa Nafady-Hego Source Type: research

Advances in Pathogenesis of Sj ögren's Syndrome
J Immunol Res. 2021 Oct 7;2021:5928232. doi: 10.1155/2021/5928232. eCollection 2021.ABSTRACTSjögren's syndrome (SS) is a chronic autoimmune disease of unknown etiology that mainly involves exocrine glands. Patients present with dry mouth and eyes, fever, arthralgia, and other systemic symptoms. In severe cases, the quality of life of patients is affected. At present, there is no cure for SS, and the treatment options are extremely limited. In recent years, studies of patients and animal models have identified abnormalities of immune cell function and cytokines to be involved in SS. A systematic review of the literatur...
Source: Journal of Immunology Research - October 18, 2021 Category: Allergy & Immunology Authors: Yao Tian Hongyi Yang Na Liu Yan Li Jie Chen Source Type: research

< em > Mycoplasma pneumoniae < /em > Seroprevalence and Total IgE Levels in Patients with Juvenile Idiopathic Arthritis
CONCLUSIONS: M. pneumoniae infection should be actively sought in children developing immune-mediated diseases, including patients affected with JIA and, especially, in oligopolyarticular forms. There is some evidence that total serum IgE levels may tend to be increased in patients with oligopolyarticular JIA subtype and especially in those resulting as M. pneumoniae seropositive. However, further and focused research is needed to confirm these preliminary results and to clarify the relation between M. pneumoniae infection, atopic status, and immune-mediated arthritis.PMID:34660816 | PMC:PMC8514930 | DOI:10.1155/2021/65965...
Source: Journal of Immunology Research - October 18, 2021 Category: Allergy & Immunology Authors: Dimitri Poddighe Diyora Abdukhakimova Kuanysh Dossybayeva Zaure Mukusheva Maykesh Assylbekova Marzhan Rakhimzhanova Aigul Ibrayeva Gaukhar Mukash Yernas Tuleutayev Source Type: research

Advances in Pathogenesis of Sj ögren's Syndrome
J Immunol Res. 2021 Oct 7;2021:5928232. doi: 10.1155/2021/5928232. eCollection 2021.ABSTRACTSjögren's syndrome (SS) is a chronic autoimmune disease of unknown etiology that mainly involves exocrine glands. Patients present with dry mouth and eyes, fever, arthralgia, and other systemic symptoms. In severe cases, the quality of life of patients is affected. At present, there is no cure for SS, and the treatment options are extremely limited. In recent years, studies of patients and animal models have identified abnormalities of immune cell function and cytokines to be involved in SS. A systematic review of the literatur...
Source: Journal of Immunology Research - October 18, 2021 Category: Allergy & Immunology Authors: Yao Tian Hongyi Yang Na Liu Yan Li Jie Chen Source Type: research

< em > Mycoplasma pneumoniae < /em > Seroprevalence and Total IgE Levels in Patients with Juvenile Idiopathic Arthritis
CONCLUSIONS: M. pneumoniae infection should be actively sought in children developing immune-mediated diseases, including patients affected with JIA and, especially, in oligopolyarticular forms. There is some evidence that total serum IgE levels may tend to be increased in patients with oligopolyarticular JIA subtype and especially in those resulting as M. pneumoniae seropositive. However, further and focused research is needed to confirm these preliminary results and to clarify the relation between M. pneumoniae infection, atopic status, and immune-mediated arthritis.PMID:34660816 | PMC:PMC8514930 | DOI:10.1155/2021/65965...
Source: Journal of Immunology Research - October 18, 2021 Category: Allergy & Immunology Authors: Dimitri Poddighe Diyora Abdukhakimova Kuanysh Dossybayeva Zaure Mukusheva Maykesh Assylbekova Marzhan Rakhimzhanova Aigul Ibrayeva Gaukhar Mukash Yernas Tuleutayev Source Type: research

Advances in Pathogenesis of Sj ögren's Syndrome
J Immunol Res. 2021 Oct 7;2021:5928232. doi: 10.1155/2021/5928232. eCollection 2021.ABSTRACTSjögren's syndrome (SS) is a chronic autoimmune disease of unknown etiology that mainly involves exocrine glands. Patients present with dry mouth and eyes, fever, arthralgia, and other systemic symptoms. In severe cases, the quality of life of patients is affected. At present, there is no cure for SS, and the treatment options are extremely limited. In recent years, studies of patients and animal models have identified abnormalities of immune cell function and cytokines to be involved in SS. A systematic review of the literatur...
Source: Journal of Immunology Research - October 18, 2021 Category: Allergy & Immunology Authors: Yao Tian Hongyi Yang Na Liu Yan Li Jie Chen Source Type: research

< em > Mycoplasma pneumoniae < /em > Seroprevalence and Total IgE Levels in Patients with Juvenile Idiopathic Arthritis
CONCLUSIONS: M. pneumoniae infection should be actively sought in children developing immune-mediated diseases, including patients affected with JIA and, especially, in oligopolyarticular forms. There is some evidence that total serum IgE levels may tend to be increased in patients with oligopolyarticular JIA subtype and especially in those resulting as M. pneumoniae seropositive. However, further and focused research is needed to confirm these preliminary results and to clarify the relation between M. pneumoniae infection, atopic status, and immune-mediated arthritis.PMID:34660816 | PMC:PMC8514930 | DOI:10.1155/2021/65965...
Source: Journal of Immunology Research - October 18, 2021 Category: Allergy & Immunology Authors: Dimitri Poddighe Diyora Abdukhakimova Kuanysh Dossybayeva Zaure Mukusheva Maykesh Assylbekova Marzhan Rakhimzhanova Aigul Ibrayeva Gaukhar Mukash Yernas Tuleutayev Source Type: research

Nicotine Exacerbates TAAD Formation Induced by Smooth Muscle-Specific Deletion of the TGF- < em > β < /em > Receptor 2
In conclusion, modeling nicotine exacerbation of TAAD formation requires optimization of chemical form, route of delivery, and dosage of the drug as well as the pathologic complexity of TAADs. Under the optimized conditions of the present study, chronic inflammation and adventitial mal-remodeling serve as critical pathways through which NFB exacerbates TAAD formation.PMID:34646889 | PMC:PMC8505064 | DOI:10.1155/2021/6880036 (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - October 14, 2021 Category: Allergy & Immunology Authors: Changzoon Chun Xiaoyan Qi Fen Wang Kyle B Madrid Lennon A Saldarriaga Max R Fisch Mark L Brantly Gilbert R Upchurch Zhihua Jiang Source Type: research

Elevated Natural Killer Cell-Mediated Cytotoxicity Is Associated with Cavity Formation in Pulmonary Tuberculosis Patients
J Immunol Res. 2021 Oct 4;2021:7925903. doi: 10.1155/2021/7925903. eCollection 2021.ABSTRACTCavitation is a major pathological feature of pulmonary tuberculosis (TB). The study is aimed at investigating the mechanism of natural killer (NK) cells participating the cavity formation during Mycobacterium tuberculosis (MTB) infection. Human peripheral blood samples were donated by pulmonary TB patients with cavity or not. Real-time quantitative PCR and enzyme-linked immunosorbent assay were performed to analyze the expression of cytokines secreted by NK cells. And the cytotoxicity of NK cells was compared between two groups. Ou...
Source: Journal of Immunology Research - October 14, 2021 Category: Allergy & Immunology Authors: Shanshan Li Dongpo Wang Panjian Wei Rongmei Liu Jidong Guo Bin Yang Hongtao Zhang Jie Lu Mengqiu Gao Yu Pang Source Type: research

Nicotine Exacerbates TAAD Formation Induced by Smooth Muscle-Specific Deletion of the TGF- < em > β < /em > Receptor 2
In conclusion, modeling nicotine exacerbation of TAAD formation requires optimization of chemical form, route of delivery, and dosage of the drug as well as the pathologic complexity of TAADs. Under the optimized conditions of the present study, chronic inflammation and adventitial mal-remodeling serve as critical pathways through which NFB exacerbates TAAD formation.PMID:34646889 | PMC:PMC8505064 | DOI:10.1155/2021/6880036 (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - October 14, 2021 Category: Allergy & Immunology Authors: Changzoon Chun Xiaoyan Qi Fen Wang Kyle B Madrid Lennon A Saldarriaga Max R Fisch Mark L Brantly Gilbert R Upchurch Zhihua Jiang Source Type: research

Elevated Natural Killer Cell-Mediated Cytotoxicity Is Associated with Cavity Formation in Pulmonary Tuberculosis Patients
J Immunol Res. 2021 Oct 4;2021:7925903. doi: 10.1155/2021/7925903. eCollection 2021.ABSTRACTCavitation is a major pathological feature of pulmonary tuberculosis (TB). The study is aimed at investigating the mechanism of natural killer (NK) cells participating the cavity formation during Mycobacterium tuberculosis (MTB) infection. Human peripheral blood samples were donated by pulmonary TB patients with cavity or not. Real-time quantitative PCR and enzyme-linked immunosorbent assay were performed to analyze the expression of cytokines secreted by NK cells. And the cytotoxicity of NK cells was compared between two groups. Ou...
Source: Journal of Immunology Research - October 14, 2021 Category: Allergy & Immunology Authors: Shanshan Li Dongpo Wang Panjian Wei Rongmei Liu Jidong Guo Bin Yang Hongtao Zhang Jie Lu Mengqiu Gao Yu Pang Source Type: research

Nicotine Exacerbates TAAD Formation Induced by Smooth Muscle-Specific Deletion of the TGF- < em > β < /em > Receptor 2
In conclusion, modeling nicotine exacerbation of TAAD formation requires optimization of chemical form, route of delivery, and dosage of the drug as well as the pathologic complexity of TAADs. Under the optimized conditions of the present study, chronic inflammation and adventitial mal-remodeling serve as critical pathways through which NFB exacerbates TAAD formation.PMID:34646889 | PMC:PMC8505064 | DOI:10.1155/2021/6880036 (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - October 14, 2021 Category: Allergy & Immunology Authors: Changzoon Chun Xiaoyan Qi Fen Wang Kyle B Madrid Lennon A Saldarriaga Max R Fisch Mark L Brantly Gilbert R Upchurch Zhihua Jiang Source Type: research

Elevated Natural Killer Cell-Mediated Cytotoxicity Is Associated with Cavity Formation in Pulmonary Tuberculosis Patients
J Immunol Res. 2021 Oct 4;2021:7925903. doi: 10.1155/2021/7925903. eCollection 2021.ABSTRACTCavitation is a major pathological feature of pulmonary tuberculosis (TB). The study is aimed at investigating the mechanism of natural killer (NK) cells participating the cavity formation during Mycobacterium tuberculosis (MTB) infection. Human peripheral blood samples were donated by pulmonary TB patients with cavity or not. Real-time quantitative PCR and enzyme-linked immunosorbent assay were performed to analyze the expression of cytokines secreted by NK cells. And the cytotoxicity of NK cells was compared between two groups. Ou...
Source: Journal of Immunology Research - October 14, 2021 Category: Allergy & Immunology Authors: Shanshan Li Dongpo Wang Panjian Wei Rongmei Liu Jidong Guo Bin Yang Hongtao Zhang Jie Lu Mengqiu Gao Yu Pang Source Type: research

Corneal Allografts: Factors for and against Acceptance
J Immunol Res. 2021 Oct 3;2021:5372090. doi: 10.1155/2021/5372090. eCollection 2021.ABSTRACTCornea is one of the most commonly transplanted tissues worldwide. However, it is usually omitted in the field of transplantology. Transplantation of the cornea is performed to treat many ocular diseases. It restores eyesight significantly improving the quality of life. Advancements in banking of explanted corneas and progressive surgical techniques increased availability and outcomes of transplantation. Despite the vast growth in the field of transplantation laboratory testing, standards for corneal transplantation still do not inc...
Source: Journal of Immunology Research - October 13, 2021 Category: Allergy & Immunology Authors: Justyna Sakowska Paulina Glasner Maciej Zieli ński Piotr Trzonkowski Leopold Glasner Source Type: research

Increased Circulating CD4 < sup > + < /sup > CXCR5 < sup > + < /sup > Cells and IgG4 Levels in Patients with Myelodysplastic Syndrome with Autoimmune Diseases
CONCLUSION: CD4+CXCR5+ cells and IgG4 levels increased in patients with MDS and AI.PMID:34631897 | PMC:PMC8497158 | DOI:10.1155/2021/4302515 (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - October 11, 2021 Category: Allergy & Immunology Authors: Na Xiao Xin He Haiyue Niu Hong Yu Ningbo Cui Hongzhao Li Li Yan Zonghong Shao Limin Xing Huaquan Wang Source Type: research

circCOL1A1 Promotes the Progression of Gastric Cancer Cells through Sponging miR-145 to Enhance RABL3 Expression
J Immunol Res. 2021 Sep 29;2021:6724854. doi: 10.1155/2021/6724854. eCollection 2021.ABSTRACTCircular RNA has been reported to be a new noncoding RNA which plays important roles in tumor progression. One of the most common functions of circular RNA is to regulate microRNA expression by acting as a microRNA sponge. However, the circular RNA expression profile and function remain mostly unclear in gastric cancer. In the study, we explored the expression and function of circCOL1A1 (hsa_circ_0044556) in gastric cancer. We performed RT-PCR with divergent primers, mRNA stability assay, and RNase R digestion assay to characterize...
Source: Journal of Immunology Research - October 11, 2021 Category: Allergy & Immunology Authors: Yue Ma Yanyi Ren Huitao Wen Chengcheng Cui Source Type: research

HIV-Related Immune Activation and Inflammation: Current Understanding and Strategies
J Immunol Res. 2021 Sep 29;2021:7316456. doi: 10.1155/2021/7316456. eCollection 2021.ABSTRACTAlthough antiretroviral therapy effectively controls human immunodeficiency virus (HIV) replication, a residual chronic immune activation/inflammation persists throughout the disease. This aberrant immune activation and inflammation are considered an accelerator of non-AIDS-related events and one of the driving forces of CD4+ T cell depletion. Unfortunately, HIV-associated immune activation is driven by various factors, while the mechanism of excessive inflammation has not been formally clarified. To date, several clinical interven...
Source: Journal of Immunology Research - October 11, 2021 Category: Allergy & Immunology Authors: Tingxia Lv Wei Cao Taisheng Li Source Type: research

Increased Circulating CD4 < sup > + < /sup > CXCR5 < sup > + < /sup > Cells and IgG4 Levels in Patients with Myelodysplastic Syndrome with Autoimmune Diseases
CONCLUSION: CD4+CXCR5+ cells and IgG4 levels increased in patients with MDS and AI.PMID:34631897 | PMC:PMC8497158 | DOI:10.1155/2021/4302515 (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - October 11, 2021 Category: Allergy & Immunology Authors: Na Xiao Xin He Haiyue Niu Hong Yu Ningbo Cui Hongzhao Li Li Yan Zonghong Shao Limin Xing Huaquan Wang Source Type: research

circCOL1A1 Promotes the Progression of Gastric Cancer Cells through Sponging miR-145 to Enhance RABL3 Expression
J Immunol Res. 2021 Sep 29;2021:6724854. doi: 10.1155/2021/6724854. eCollection 2021.ABSTRACTCircular RNA has been reported to be a new noncoding RNA which plays important roles in tumor progression. One of the most common functions of circular RNA is to regulate microRNA expression by acting as a microRNA sponge. However, the circular RNA expression profile and function remain mostly unclear in gastric cancer. In the study, we explored the expression and function of circCOL1A1 (hsa_circ_0044556) in gastric cancer. We performed RT-PCR with divergent primers, mRNA stability assay, and RNase R digestion assay to characterize...
Source: Journal of Immunology Research - October 11, 2021 Category: Allergy & Immunology Authors: Yue Ma Yanyi Ren Huitao Wen Chengcheng Cui Source Type: research

HIV-Related Immune Activation and Inflammation: Current Understanding and Strategies
J Immunol Res. 2021 Sep 29;2021:7316456. doi: 10.1155/2021/7316456. eCollection 2021.ABSTRACTAlthough antiretroviral therapy effectively controls human immunodeficiency virus (HIV) replication, a residual chronic immune activation/inflammation persists throughout the disease. This aberrant immune activation and inflammation are considered an accelerator of non-AIDS-related events and one of the driving forces of CD4+ T cell depletion. Unfortunately, HIV-associated immune activation is driven by various factors, while the mechanism of excessive inflammation has not been formally clarified. To date, several clinical interven...
Source: Journal of Immunology Research - October 11, 2021 Category: Allergy & Immunology Authors: Tingxia Lv Wei Cao Taisheng Li Source Type: research

Increased Circulating CD4 < sup > + < /sup > CXCR5 < sup > + < /sup > Cells and IgG4 Levels in Patients with Myelodysplastic Syndrome with Autoimmune Diseases
CONCLUSION: CD4+CXCR5+ cells and IgG4 levels increased in patients with MDS and AI.PMID:34631897 | PMC:PMC8497158 | DOI:10.1155/2021/4302515 (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - October 11, 2021 Category: Allergy & Immunology Authors: Na Xiao Xin He Haiyue Niu Hong Yu Ningbo Cui Hongzhao Li Li Yan Zonghong Shao Limin Xing Huaquan Wang Source Type: research

circCOL1A1 Promotes the Progression of Gastric Cancer Cells through Sponging miR-145 to Enhance RABL3 Expression
J Immunol Res. 2021 Sep 29;2021:6724854. doi: 10.1155/2021/6724854. eCollection 2021.ABSTRACTCircular RNA has been reported to be a new noncoding RNA which plays important roles in tumor progression. One of the most common functions of circular RNA is to regulate microRNA expression by acting as a microRNA sponge. However, the circular RNA expression profile and function remain mostly unclear in gastric cancer. In the study, we explored the expression and function of circCOL1A1 (hsa_circ_0044556) in gastric cancer. We performed RT-PCR with divergent primers, mRNA stability assay, and RNase R digestion assay to characterize...
Source: Journal of Immunology Research - October 11, 2021 Category: Allergy & Immunology Authors: Yue Ma Yanyi Ren Huitao Wen Chengcheng Cui Source Type: research

HIV-Related Immune Activation and Inflammation: Current Understanding and Strategies
J Immunol Res. 2021 Sep 29;2021:7316456. doi: 10.1155/2021/7316456. eCollection 2021.ABSTRACTAlthough antiretroviral therapy effectively controls human immunodeficiency virus (HIV) replication, a residual chronic immune activation/inflammation persists throughout the disease. This aberrant immune activation and inflammation are considered an accelerator of non-AIDS-related events and one of the driving forces of CD4+ T cell depletion. Unfortunately, HIV-associated immune activation is driven by various factors, while the mechanism of excessive inflammation has not been formally clarified. To date, several clinical interven...
Source: Journal of Immunology Research - October 11, 2021 Category: Allergy & Immunology Authors: Tingxia Lv Wei Cao Taisheng Li Source Type: research

The Immunomodulation Potential of Exosomes in Tumor Microenvironment
J Immunol Res. 2021 Sep 27;2021:3710372. doi: 10.1155/2021/3710372. eCollection 2021.ABSTRACTExosomes are lipid bilayer particles that originated from almost all types of cells and play an important role in intercellular communication. Tumor-derived exosomes contain large amounts of noncoding RNA, DNA, and proteins, which can be transferred into recipient cells as functional components in exosomes. These exosomal functional constituents depend on the originating cells, and it has been proved that types and numbers of exosomal components differ in cancer patients and healthy individuals. This review summarizes the role of t...
Source: Journal of Immunology Research - October 7, 2021 Category: Allergy & Immunology Authors: Meng Wang Bo Zhang Source Type: research

Inhaled [D-Ala < sup > 2 < /sup > ]-Dynorphin 1-6 Prevents Hyperacetylation and Release of High Mobility Group Box 1 in a Mouse Model of Acute Lung Injury
In this study, we demonstrate that inhaled [D-Ala2]-dynorphin 1-6 (leytragin), a peptide agonist of δ-opioid receptors, significantly inhibits HMGB1 secretion in mice with lipopolysaccharide- (LPS-) induced acute lung injury. The mechanism of action involves preventing HMGB1's hyperacetylation at critical lysine residues within nuclear localization sites, as well as promoting the expression of sirtuin 1 (SIRT1), an enzyme known to deacetylate HMGB1. Leytragin's effects are mediated by opioid receptors, since naloxone, an antagonist of opioid receptors, abrogates the leytragin effect on SIRT1 expression. Overall, our ...
Source: Journal of Immunology Research - October 7, 2021 Category: Allergy & Immunology Authors: Vladislav N Karkischenko Veronika I Skvortsova Melik T Gasanov Yuriy V Fokin Maxim S Nesterov Nataliya V Petrova Oxana V Alimkina Igor A Pomytkin Source Type: research

Integrated Bioinformatics and Experimental Approaches Identified the Role of NPPA in the Proliferation and the Malignant Behavior of Breast Cancer
In this study, we aimed to demonstrate the value of extracellular matrix- (ECM-) related genes in breast cancer patients. The overall expression of ECM is assessed with a novel SC3 clustering method, and patients were divided into two clusters with diverse recurrence rate. We established the Cox regression model in breast cancer patients and identified NPPA as an independent prognostic marker. The NPPA expression is downregulated in breast cancer patients, independent of the ER status, PR status, stemness score, and immune infiltrating condition. And we observed the enhanced proliferation, migration, and invasion potential...
Source: Journal of Immunology Research - October 7, 2021 Category: Allergy & Immunology Authors: Aijun Sun Xiaonan Sheng Jinhai Tang Zhenfeng Yu Jian Zhang Source Type: research

The Immunomodulation Potential of Exosomes in Tumor Microenvironment
J Immunol Res. 2021 Sep 27;2021:3710372. doi: 10.1155/2021/3710372. eCollection 2021.ABSTRACTExosomes are lipid bilayer particles that originated from almost all types of cells and play an important role in intercellular communication. Tumor-derived exosomes contain large amounts of noncoding RNA, DNA, and proteins, which can be transferred into recipient cells as functional components in exosomes. These exosomal functional constituents depend on the originating cells, and it has been proved that types and numbers of exosomal components differ in cancer patients and healthy individuals. This review summarizes the role of t...
Source: Journal of Immunology Research - October 7, 2021 Category: Allergy & Immunology Authors: Meng Wang Bo Zhang Source Type: research

Inhaled [D-Ala < sup > 2 < /sup > ]-Dynorphin 1-6 Prevents Hyperacetylation and Release of High Mobility Group Box 1 in a Mouse Model of Acute Lung Injury
In this study, we demonstrate that inhaled [D-Ala2]-dynorphin 1-6 (leytragin), a peptide agonist of δ-opioid receptors, significantly inhibits HMGB1 secretion in mice with lipopolysaccharide- (LPS-) induced acute lung injury. The mechanism of action involves preventing HMGB1's hyperacetylation at critical lysine residues within nuclear localization sites, as well as promoting the expression of sirtuin 1 (SIRT1), an enzyme known to deacetylate HMGB1. Leytragin's effects are mediated by opioid receptors, since naloxone, an antagonist of opioid receptors, abrogates the leytragin effect on SIRT1 expression. Overall, our ...
Source: Journal of Immunology Research - October 7, 2021 Category: Allergy & Immunology Authors: Vladislav N Karkischenko Veronika I Skvortsova Melik T Gasanov Yuriy V Fokin Maxim S Nesterov Nataliya V Petrova Oxana V Alimkina Igor A Pomytkin Source Type: research

Integrated Bioinformatics and Experimental Approaches Identified the Role of NPPA in the Proliferation and the Malignant Behavior of Breast Cancer
In this study, we aimed to demonstrate the value of extracellular matrix- (ECM-) related genes in breast cancer patients. The overall expression of ECM is assessed with a novel SC3 clustering method, and patients were divided into two clusters with diverse recurrence rate. We established the Cox regression model in breast cancer patients and identified NPPA as an independent prognostic marker. The NPPA expression is downregulated in breast cancer patients, independent of the ER status, PR status, stemness score, and immune infiltrating condition. And we observed the enhanced proliferation, migration, and invasion potential...
Source: Journal of Immunology Research - October 7, 2021 Category: Allergy & Immunology Authors: Aijun Sun Xiaonan Sheng Jinhai Tang Zhenfeng Yu Jian Zhang Source Type: research

The Immunomodulation Potential of Exosomes in Tumor Microenvironment
J Immunol Res. 2021 Sep 27;2021:3710372. doi: 10.1155/2021/3710372. eCollection 2021.ABSTRACTExosomes are lipid bilayer particles that originated from almost all types of cells and play an important role in intercellular communication. Tumor-derived exosomes contain large amounts of noncoding RNA, DNA, and proteins, which can be transferred into recipient cells as functional components in exosomes. These exosomal functional constituents depend on the originating cells, and it has been proved that types and numbers of exosomal components differ in cancer patients and healthy individuals. This review summarizes the role of t...
Source: Journal of Immunology Research - October 7, 2021 Category: Allergy & Immunology Authors: Meng Wang Bo Zhang Source Type: research

Inhaled [D-Ala < sup > 2 < /sup > ]-Dynorphin 1-6 Prevents Hyperacetylation and Release of High Mobility Group Box 1 in a Mouse Model of Acute Lung Injury
In this study, we demonstrate that inhaled [D-Ala2]-dynorphin 1-6 (leytragin), a peptide agonist of δ-opioid receptors, significantly inhibits HMGB1 secretion in mice with lipopolysaccharide- (LPS-) induced acute lung injury. The mechanism of action involves preventing HMGB1's hyperacetylation at critical lysine residues within nuclear localization sites, as well as promoting the expression of sirtuin 1 (SIRT1), an enzyme known to deacetylate HMGB1. Leytragin's effects are mediated by opioid receptors, since naloxone, an antagonist of opioid receptors, abrogates the leytragin effect on SIRT1 expression. Overall, our ...
Source: Journal of Immunology Research - October 7, 2021 Category: Allergy & Immunology Authors: Vladislav N Karkischenko Veronika I Skvortsova Melik T Gasanov Yuriy V Fokin Maxim S Nesterov Nataliya V Petrova Oxana V Alimkina Igor A Pomytkin Source Type: research

Integrated Bioinformatics and Experimental Approaches Identified the Role of NPPA in the Proliferation and the Malignant Behavior of Breast Cancer
In this study, we aimed to demonstrate the value of extracellular matrix- (ECM-) related genes in breast cancer patients. The overall expression of ECM is assessed with a novel SC3 clustering method, and patients were divided into two clusters with diverse recurrence rate. We established the Cox regression model in breast cancer patients and identified NPPA as an independent prognostic marker. The NPPA expression is downregulated in breast cancer patients, independent of the ER status, PR status, stemness score, and immune infiltrating condition. And we observed the enhanced proliferation, migration, and invasion potential...
Source: Journal of Immunology Research - October 7, 2021 Category: Allergy & Immunology Authors: Aijun Sun Xiaonan Sheng Jinhai Tang Zhenfeng Yu Jian Zhang Source Type: research

Stress Induces Release of Extracellular Vesicles by < em > Trypanosoma cruzi < /em > Trypomastigotes
In conclusion, our results suggest a budding mechanism of release, dependent on the membrane structure and parasite integrity. Stress conditions did not affect functional properties of EVs during interaction with host cells. EV release variations under stress conditions may be a physiological response against environmental changes.PMID:34604391 | PMC:PMC8486533 | DOI:10.1155/2021/2939693 (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - October 4, 2021 Category: Allergy & Immunology Authors: Camilla Ioshida Vasconcelos A Cronemberger-Andrade Normanda Souza-Melo Juliana Terzi Maricato Patr ícia Xander Wagner Luiz Batista Rodrigo Pedro Soares Sergio Schenkman Ana Claudia Torrecilhas Source Type: research

SLC2A5 Correlated with Immune Infiltration: A Candidate Diagnostic and Prognostic Biomarker for Lung Adenocarcinoma
This study is aimed at elucidating the function of SLC2A5 in the prognosis and pathogenesis of LUAD by analyzing public databases. The differential expression of SLC2A5 in various tissues from Oncomine, GEPIA, and other databases was obtained, and SLC2A5 expression at the protein level in normal and tumor tissues was detected with the use of the HPA database. Then, we used the UALCAN database to analyze the expression of SLC2A5 in different clinical feature subgroups. Notably, in both PrognoScan and Kaplan-Meier plotter databases, we found a certain association between SLC2A5 and poor OS outcomes in LUAD patients. Studies ...
Source: Journal of Immunology Research - October 4, 2021 Category: Allergy & Immunology Authors: Lianxiang Luo Jiating Su Yushi Zheng Fangfang Huang Riming Huang Hui Luo Source Type: research

Stress Induces Release of Extracellular Vesicles by < em > Trypanosoma cruzi < /em > Trypomastigotes
In conclusion, our results suggest a budding mechanism of release, dependent on the membrane structure and parasite integrity. Stress conditions did not affect functional properties of EVs during interaction with host cells. EV release variations under stress conditions may be a physiological response against environmental changes.PMID:34604391 | PMC:PMC8486533 | DOI:10.1155/2021/2939693 (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - October 4, 2021 Category: Allergy & Immunology Authors: Camilla Ioshida Vasconcelos A Cronemberger-Andrade Normanda Souza-Melo Juliana Terzi Maricato Patr ícia Xander Wagner Luiz Batista Rodrigo Pedro Soares Sergio Schenkman Ana Claudia Torrecilhas Source Type: research

SLC2A5 Correlated with Immune Infiltration: A Candidate Diagnostic and Prognostic Biomarker for Lung Adenocarcinoma
This study is aimed at elucidating the function of SLC2A5 in the prognosis and pathogenesis of LUAD by analyzing public databases. The differential expression of SLC2A5 in various tissues from Oncomine, GEPIA, and other databases was obtained, and SLC2A5 expression at the protein level in normal and tumor tissues was detected with the use of the HPA database. Then, we used the UALCAN database to analyze the expression of SLC2A5 in different clinical feature subgroups. Notably, in both PrognoScan and Kaplan-Meier plotter databases, we found a certain association between SLC2A5 and poor OS outcomes in LUAD patients. Studies ...
Source: Journal of Immunology Research - October 4, 2021 Category: Allergy & Immunology Authors: Lianxiang Luo Jiating Su Yushi Zheng Fangfang Huang Riming Huang Hui Luo Source Type: research

Stress Induces Release of Extracellular Vesicles by < em > Trypanosoma cruzi < /em > Trypomastigotes
In conclusion, our results suggest a budding mechanism of release, dependent on the membrane structure and parasite integrity. Stress conditions did not affect functional properties of EVs during interaction with host cells. EV release variations under stress conditions may be a physiological response against environmental changes.PMID:34604391 | PMC:PMC8486533 | DOI:10.1155/2021/2939693 (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - October 4, 2021 Category: Allergy & Immunology Authors: Camilla Ioshida Vasconcelos A Cronemberger-Andrade Normanda Souza-Melo Juliana Terzi Maricato Patr ícia Xander Wagner Luiz Batista Rodrigo Pedro Soares Sergio Schenkman Ana Claudia Torrecilhas Source Type: research

SLC2A5 Correlated with Immune Infiltration: A Candidate Diagnostic and Prognostic Biomarker for Lung Adenocarcinoma
This study is aimed at elucidating the function of SLC2A5 in the prognosis and pathogenesis of LUAD by analyzing public databases. The differential expression of SLC2A5 in various tissues from Oncomine, GEPIA, and other databases was obtained, and SLC2A5 expression at the protein level in normal and tumor tissues was detected with the use of the HPA database. Then, we used the UALCAN database to analyze the expression of SLC2A5 in different clinical feature subgroups. Notably, in both PrognoScan and Kaplan-Meier plotter databases, we found a certain association between SLC2A5 and poor OS outcomes in LUAD patients. Studies ...
Source: Journal of Immunology Research - October 4, 2021 Category: Allergy & Immunology Authors: Lianxiang Luo Jiating Su Yushi Zheng Fangfang Huang Riming Huang Hui Luo Source Type: research

Remote Inflammatory Preconditioning Alleviates Lipopolysaccharide-Induced Acute Lung Injury via Inhibition of Intrinsic Apoptosis in Rats
CONCLUSION: RInPC could inhibit inflammation and attenuate oxidative stress, thereby reducing intrinsic apoptosis and providing lung protection in the LPS-induced ALI in rats.PMID:34595242 | PMC:PMC8478588 | DOI:10.1155/2021/1125199 (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - October 1, 2021 Category: Allergy & Immunology Authors: Yong Liu Jiahang Xu Liang Zhao Jing Cheng Baojun Chen Source Type: research

Interleukin-6 versus Common Inflammatory Biomarkers for Diagnosing Fracture-Related Infection: Utility and Potential Influencing Factors
This study is aimed at investigating the utility and potential influencing factors of IL-6 and the common biomarkers for diagnosing FRI. Preoperative serological levels of IL-6 and the three biomarkers were compared between 407 FRI patients and 195 fracture-healed (FH) patients. Diagnostic efficiency of the indicators was evaluated using the areas under the receiver operating characteristic (ROC) curves, and their potential influencing factors were also analyzed. Outcomes showed that the median levels of all of the four biomarkers were significantly higher among the FRI patients than those among the FH patients (P
Source: Journal of Immunology Research - October 1, 2021 Category: Allergy & Immunology Authors: Xing-Qi Zhao Hao-Yang Wan Han-Jun Qin Nan Jiang Bin Yu Source Type: research

The Role of Inflammasome Activation in Early HIV Infection
J Immunol Res. 2021 Sep 20;2021:1487287. doi: 10.1155/2021/1487287. eCollection 2021.ABSTRACTThe inflammasome pathway is an important arm of the innate immune system that provides antiviral immunity against many viruses. The main pathways involved in virus infections include the NLRP3, IFI16, and AIM2 pathways. However, a succinct understanding of its role in HIV is not yet well elucidated. In this review, we showed that NLRP3 inflammasome activation plays a vital role in inhibiting HIV entry into target cells via the purinergic pathway; IFI16 detects intracellular HIV ssDNA, triggers interferon I and III production, and i...
Source: Journal of Immunology Research - October 1, 2021 Category: Allergy & Immunology Authors: Cyril Jabea Ekabe Njinju Asaba Clinton Jules Kehbila Ngangom Chouamo Franck Source Type: research