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HLA Association with Drug-Induced Adverse Reactions.
Authors: Fan WL, Shiao MS, Hui RC, Su SC, Wang CW, Chang YC, Chung WH Abstract Adverse drug reactions (ADRs) remain a common and major problem in healthcare. Severe cutaneous adverse drug reactions (SCARs), such as Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) with mortality rate ranges from 10% to more than 30%, can be life threatening. A number of recent studies demonstrated that ADRs possess strong genetic predisposition. ADRs induced by several drugs have been shown to have significant associations with specific alleles of human leukocyte antigen (HLA) genes. For example, hypersensitivity to a...
Source: Journal of Immunology Research - January 17, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Immune-Stimulatory and Therapeutic Activity of Tinospora cordifolia: Double-Edged Sword against Salmonellosis.
Authors: Alsuhaibani S, Khan MA Abstract The present study was aimed at determining the activity of aqueous and methanolic extracts of Tinospora cordifolia (AETC and METC) against Salmonella typhimurium. In vitro anti-Salmonella activity of T. cordifolia was determined through the broth dilution and agar well diffusion assays. The immune-stimulating potential of AETC or METC was determined by measuring the cytokine levels in the culture supernatants of treated murine J774 macrophages. Antibacterial activity of AETC or METC was determined by treating S. typhimurium-infected macrophages and BALB/C mice. The toxicity ...
Source: Journal of Immunology Research - January 12, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Activation of Peptidylarginine Deiminase in the Salivary Glands of Balb/c Mice Drives the Citrullination of Ro and La Ribonucleoproteins.
Authors: Rodríguez-Rodríguez M, Herrera-Esparza R, Bollain Y Goytia JJ, Pérez-Pérez ME, Pacheco-Tovar D, Murillo-Vázquez J, Pacheco-Tovar G, Avalos-Díaz E Abstract The goal of the present study was to determine whether peptidylarginine deiminase PAD2 and PAD4 enzymes are present in Balb/c mouse salivary glands and whether they are able to citrullinate Ro and La ribonucleoproteins. Salivary glands from Balb/c mice were cultured in DMEM and supplemented with one of the following stimulants: ATP, LPS, TNF, IFNγ, or IL-6. A control group without stimulant was also evaluat...
Source: Journal of Immunology Research - January 12, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Inflammatory Cytokine Pattern Is Sex-Dependent in Mouse Cutaneous Melanoma Experimental Model.
We present the evaluation of inflammatory cytokines in mouse cutaneous melanoma experimental model, as markers of disease evolution. Moreover, to test our experimental model, we have used low doses of dacarbazine (DTIC). C57 BL/6J mouse of both sexes were subjected to experimental cutaneous melanoma and treated with low doses of DTIC. Clinical parameters and serum cytokines were followed during tumor evolution and during DTIC therapy. Cytokine/chemokine pattern was assessed using xMAP technology and the following molecules were quantified: interleukins (IL)-1-beta, IL-6, IL-10, IL-12 (p70), interferon (IFN)-gamma, granuloc...
Source: Journal of Immunology Research - January 12, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Genetic Factors of Autoimmune Diseases 2017.
Authors: Ceccarelli F, Agmon-Levin N, Perricone C PMID: 29270439 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - December 23, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Stabilized β-Catenin Ameliorates ALPS-Like Symptoms of B6/lpr Mice.
Stabilized β-Catenin Ameliorates ALPS-Like Symptoms of B6/lpr Mice. J Immunol Res. 2017;2017:3469108 Authors: Xu X, Huang J, Zhao M, Chen H, Mo J, Zhou X, Su Q, Yu B, Huang Z Abstract Autoimmune lymphoproliferative syndrome (ALPS) is an incurable disease mainly caused by the defect of Fas-mediated apoptosis and characterized by nonmalignant autoimmune lymphoproliferation. Stabilized β-catenin could not only potentiate Fas-mediated T cell apoptosis via upregulating the expression of Fas on activated T cells, but also potentiate T cell apoptosis via intrinsic apoptotic pathway. In the present s...
Source: Journal of Immunology Research - December 20, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Are the Therapeutic Effects of Huangqi (Astragalus membranaceus) on Diabetic Nephropathy Correlated with Its Regulation of Macrophage iNOS Activity?
Conclusions: Huangqi can regulate iNOS activity of macrophages in different states in vitro. These biphasic or antagonistic effects may explain why Huangqi can be used to treat different stages of DN. PMID: 29250558 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - December 20, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Beta-Defensin-2 and Beta-Defensin-3 Reduce Intestinal Damage Caused by Salmonella typhimurium Modulating the Expression of Cytokines and Enhancing the Probiotic Activity of Enterococcus faecium.
Authors: Fusco A, Savio V, Cammarota M, Alfano A, Schiraldi C, Donnarumma G Abstract The intestinal microbiota is a major factor in human health and disease. This microbial community includes autochthonous (permanent inhabitants) and allochthonous (transient inhabitants) microorganisms that contribute to maintaining the integrity of the intestinal wall, modulating responses to pathogenic noxae and representing a key factor in the maturation of the immune system. If this healthy microbiota is disrupted by antibiotics, chemotherapy, or a change in diet, intestinal colonization by pathogenic bacteria or viruses may oc...
Source: Journal of Immunology Research - December 20, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Pulmonary Susceptibility of Neonates to Respiratory Syncytial Virus Infection: A Problem of Innate Immunity?
Authors: Drajac C, Laubreton D, Riffault S, Descamps D Abstract Human respiratory syncytial virus (RSV) is a common and highly contagious viral agent responsible for acute lower respiratory infection in infants. This pathology characterized by mucus hypersecretion and a disturbed T cell immune response is one of the major causes of infant hospitalization for severe bronchiolitis. Although different risk factors are associated with acute RSV bronchiolitis, the immunological factors contributing to the susceptibility of RSV infection in infants are not clearly elucidated. Epidemiological studies have established that...
Source: Journal of Immunology Research - December 20, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

TNF Tolerance in Monocytes and Macrophages: Characteristics and Molecular Mechanisms.
Authors: Huber R, Bikker R, Welz B, Christmann M, Brand K Abstract Tumor necrosis factor (TNF) tolerance in monocytes and macrophages means that preexposure to TNF reduces the sensitivity in these cells to a subsequent restimulation with this cytokine. Differential effects arise following preincubation with both low and high doses of TNF resulting in absolute as well as induction tolerance affecting specific immunologically relevant gene sets. In this review article, we summarize the relevance of TNF tolerance in vivo and the molecular mechanisms underlying these forms of tolerance including the role of transcripti...
Source: Journal of Immunology Research - December 20, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Porcine to Human Heart Transplantation: Is Clinical Application Now Appropriate?
Authors: McGregor CGA, Byrne GW Abstract Cardiac xenotransplantation (CXTx) is a promising solution to the chronic shortage of donor hearts. Recent advancements in immune suppression have greatly improved the survival of heterotopic CXTx, now extended beyond 2 years, and life-supporting kidney XTx. Advances in donor genetic modification (B4GALNT2 and CMAH mutations) with proven Gal-deficient donors expressing human complement regulatory protein(s) have also accelerated, reducing donor pig organ antigenicity. These advances can now be combined and tested in life-supporting orthotopic preclinical studies in nonhuman ...
Source: Journal of Immunology Research - December 16, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Neutrophils: Their Role in Innate and Adaptive Immunity 2017.
Authors: Rosales C, Lowell CA, Schnoor M, Uribe-Querol E PMID: 29238732 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - December 16, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Local and Systemic CD4+ T Cell Exhaustion Reverses with Clinical Resolution of Pulmonary Sarcoidosis.
Authors: Hawkins C, Shaginurova G, Shelton DA, Herazo-Maya JD, Oswald-Richter KA, Rotsinger JE, Young A, Celada LJ, Kaminski N, Sevin C, Drake WP Abstract Investigation of the Th1 immune response in sarcoidosis CD4+ T cells has revealed reduced proliferative capacity and cytokine expression upon TCR stimulation. In other disease models, such cellular dysfunction has been associated with a step-wise, progressive loss of T cell function that results from chronic antigenic stimulation. T cell exhaustion is defined by decreased cytokine production upon TCR activation, decreased proliferation, increased expression of in...
Source: Journal of Immunology Research - December 15, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

MicroRNAs Regulate Thymic Epithelium in Age-Related Thymic Involution via Down- or Upregulation of Transcription Factors.
Authors: Xu M, Zhang X, Hong R, Su DM, Wang L Abstract Age-related thymic involution is primarily induced by defects in nonhematopoietic thymic epithelial cells (TECs). It is characterized by dysfunction of multiple transcription factors (TFs), such as p63 and FoxN1, and also involves other TEC-associated regulators, such as Aire. These TFs and regulators are controlled by complicated regulatory networks, in which microRNAs (miRNAs) act as a key player. miRNAs can either directly target the 3'-UTRs (untranslated regions) of the TFs to suppress TF expression or target TF inhibitors to reduce or increase TF inhibitor...
Source: Journal of Immunology Research - December 13, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Fas-Related Apoptosis of Peritoneal Fluid Macrophages in Endometriosis Patients: Understanding the Disease.
Authors: Gogacz M, Gałczyński K, Wojtaś M, Winkler I, Adamiak A, Romanek-Piva K, Rechberger T, Kotarski J Abstract Recent studies of the peritoneal cavity environment in endometriosis demonstrate quantitative and qualitative changes in the cells responsible for cell-mediated immunity. Such changes may have led to disturbances in the surveillance, recognition, and destruction of misplaced endometrial cells and might have, in fact, brought about the disease. The aim of the study was to assess CD95 (Fas) expression on (activated) peritoneal fluid (PF) macrophages, as well as to ascertain soluble Fas (sFas) concentr...
Source: Journal of Immunology Research - December 13, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Corrigendum to "The Controversial C5a Receptor C5aR2: Its Role in Health and Disease".
Corrigendum to "The Controversial C5a Receptor C5aR2: Its Role in Health and Disease". J Immunol Res. 2017;2017:6073961 Authors: Zhang T, Garstka MA, Li K Abstract [This corrects the article DOI: 10.1155/2017/8193932.]. PMID: 29226158 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - December 13, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Immunohistopathological Findings of Severe Cutaneous Adverse Drug Reactions.
Authors: Orime M Abstract Diagnosis of severe cutaneous adverse drug reactions should involve immunohistopathological examination, which gives insight into the pathomechanisms of these disorders. The characteristic histological findings of erythema multiforme (EM), Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) provide conclusive evidence demonstrating that SJS/TEN can be distinguished from EM. Established SJS/TEN shows full-thickness, extensive keratinocyte necrosis that develops into subepidermal bullae. Drug-induced hypersensitivity syndrome (DIHS) and exanthema in drug reaction with eosino...
Source: Journal of Immunology Research - December 13, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Immune Dysfunction in HIV: A Possible Role for Pro- and Anti-Inflammatory Cytokines in HIV Staging.
Authors: Akase IE, Musa BOP, Obiako RO, Ahmad Elfulatiy A, Mohammed AA Abstract HIV infection is a chronic infection that almost inevitably progresses to AIDS. The infection is characterized by the deterioration in the immune function leading to opportunistic infections and malignancies. Additionally, there is an associated immune dysfunction characterized by a persistent inflammatory state and unhealthy elaboration of both pro- and anti-inflammatory cytokines. The CD4+ T cell count has been used as a surrogate for the level of immune dysfunction that exists in patients with HIV infection. Eighty-eight (88) patient...
Source: Journal of Immunology Research - December 13, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Comparison of Myeloid Cells in Circulation and in the Tumor Microenvironment of Patients with Colorectal and Breast Cancers.
In this report, we compared levels of myeloid cells between these two common cancers and have added data from more cancer patients. We also investigated associations between clinical stage/histological grade of tumors and levels of myeloid cells in cancer patients. We found that although granulocytic myeloid cells were expanded in the TME of both PBC and CRC patients, the levels of these cells were significantly higher in the TME of CRC patients. Moreover, our results indicate that increased levels of circulating granulocytic myeloid cells are associated with poorly differentiated tumors in CRC patients. Taken together, th...
Source: Journal of Immunology Research - December 13, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Neuroprotective Potential of Gentongping in Rat Model of Cervical Spondylotic Radiculopathy Targeting PPAR- γ Pathway.
Neuroprotective Potential of Gentongping in Rat Model of Cervical Spondylotic Radiculopathy Targeting PPAR-γ Pathway. J Immunol Res. 2017;2017:9152960 Authors: Sun W, Zheng K, Liu B, Fan D, Luo H, Qu X, Li L, He X, Yi J, Lu C Abstract Cervical spondylotic radiculopathy (CSR) is the most general form of spinal degenerative disease and is characterized by pain and numbness of the neck and arm. Gentongping (GTP) granule, as a classical Chinese patent medicine, has been widely used in curing CSR, whereas the underlying mechanism remains unclear. Therefore, the aim of this study is to explore the phar...
Source: Journal of Immunology Research - December 13, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Protective Effects of Moringa oleifera on HBV Genotypes C and H Transiently Transfected Huh7 Cells.
In this study, the effect of M. oleifera was evaluated in Huh7 cells expressing either HBV genotypes C or H for the antiviral, antifibrotic, anti-inflammatory, and antioxidative responses. Huh7 cells were treated with an aqueous extract of M. oleifera (leaves) at doses of 0, 30, 45, or 60 μg/mL. The replicative virus and TGF-β1, CTGF, CAT, IFN-β1, and pgRNA expressions were measured by real time. HBsAg and IL-6 titers were determined by ELISA. CTGF, TGF-β1, IFN-β1, and pgRNA expressions decreased with M. oleifera treatment irrespective of the HBV genotype. HBsAg secretion in the supernatant of transf...
Source: Journal of Immunology Research - December 9, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Administration of Rhodiola kirilowii Extracts during Mouse Pregnancy and Lactation Stimulates Innate but Not Adaptive Immunity of the Offspring.
In conclusion, the long-term supplementation of mouse mothers during pregnancy and lactation with RKW or RKW-A extracts affects the immune system of their progeny. These results should be taken into consideration before administration of Rhodiola kirilowii to pregnant and lactating women. PMID: 29214185 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - December 9, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Immunization with Bivalent Flagellin Protects Mice against Fatal Pseudomonas aeruginosa Pneumonia.
In conclusion, bivalent flagellin vaccine can confer protection against different strains of P. aeruginosa in an acute pneumonia mouse model by eliciting effective cellular and humoral immune responses, including increased IL-17 production and improved opsonophagocytic killing. PMID: 29201922 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - December 6, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Regulation of Leukocyte Recruitment to the Spleen and Peritoneal Cavity during Pristane-Induced Inflammation.
Authors: Li Y, Wu J, Xu L, Wu Q, Wan Z, Li L, Yu H, Li X, Li K, Zhang Q, Hou Z, Sun X, Chen H Abstract Chronic inflammation is associated with an increased number of leukocytes in the spleen, which are then redirected to the site of inflammation. However, it remains unknown how leukocyte recruitment is regulated. Herein, chronic inflammation was induced by intraperitoneal injection of pristane into mice. Leukocytes in the spleen or in the peritoneal cavity were quantified by flow cytometry. We found that the loss of IL-6 decreased macrophage recruitment to the spleen and the peritoneal cavity during pristane-induce...
Source: Journal of Immunology Research - December 6, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Targeting of Immune Cells by Dual TLR2/7 Ligands Suppresses Features of Allergic Th2 Immune Responses in Mice.
Conclusions: Based on beneficial immune-modulating properties, CL413 and CL531 may have utility as potential adjuvants for allergy treatment. PMID: 29204451 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - December 6, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Endothelial STAT3 Modulates Protective Mechanisms in a Mouse Ischemia-Reperfusion Model of Acute Kidney Injury.
Authors: Dube S, Matam T, Yen J, Mang HE, Dagher PC, Hato T, Sutton TA Abstract STAT3 is a transcriptional regulator that plays an important role in coordinating inflammation and immunity. In addition, there is a growing appreciation of the role STAT3 signaling plays in response to organ injury following diverse insults. Acute kidney injury (AKI) from ischemia-reperfusion injury is a common clinical entity with devastating consequences, and the recognition that endothelial alterations contribute to kidney dysfunction in this setting is of growing interest. Consequently, we used a mouse with a genetic deletion of St...
Source: Journal of Immunology Research - November 29, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

CD80 Expressed by CD8+ T Cells Contributes to PD-L1-Induced Apoptosis of Activated CD8+ T Cells.
Authors: Rollins MR, Gibbons Johnson RM Abstract Tumor cells are capable of limiting antitumor CD8+ T cell responses through their cell surface expression of PD-L1. In addition to PD-1 expressed by CD8+ T cells, PD-L1 also binds to CD80 expressed by CD8+ T cells. The influence of the PD-L1/CD80 interaction on CD8+ T cell function has not been fully characterized, so we sought to investigate the impact of the PD-L1/CD80 interaction on PD-L1-induced apoptosis of activated CD8+ T cells. We found that CD8+ T cells that lacked CD80 expression got activated to the same extent as wild-type CD8+ T cells, but when cultured ...
Source: Journal of Immunology Research - November 29, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Toll-Like Receptor Ligand-Induced Liver Injury in D-Galactosamine-Sensitized Mice: Differences between TLR7/8 and TLR9 Ligands, Cytokine Patterns, and Cross-Tolerance Induction by TLR2 Ligand Pretreatment.
Authors: Seki R Abstract Administration of Toll-like receptor ligands (TLRLs) is known to cause liver injury in D-galN-sensitized mice. In the present study, we aimed to complement preceding reports on the TLRL/D-galN system by analyzing comparisons among TLRLs, mouse strain dependence, effects on serum levels of cytokines, and effects of sequential administrations of different TLRLs. In a preliminary set of analyses, we first confirmed that liver failure can be induced by diverse TLRLs, including LTA and R848 in combination with D-galN. Analysis using TLR4-deficient mice excluded potential confounding effects of e...
Source: Journal of Immunology Research - November 29, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Protective Effects of Ophiocordyceps lanpingensis on Glycerol-Induced Acute Renal Failure in Mice.
Conclusion: OL could ameliorate renal dysfunction in glycerol-induced ARF in mice by inhibiting oxidative stress and enhancing immune response. PMID: 29159186 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - November 23, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

The Role of Costimulation Blockade in Solid Organ and Islet Xenotransplantation.
Authors: Samy KP, Butler JR, Li P, Cooper DKC, Ekser B Abstract Pig-to-human xenotransplantation offers a potential bridge to the growing disparity between patients with end-stage organ failure and graft availability. Early studies attempting to overcome cross-species barriers demonstrated robust humoral immune responses to discordant xenoantigens. Recent advances have led to highly efficient and targeted genomic editing, drastically altering the playing field towards rapid production of less immunogenic porcine tissues and even the discussion of human xenotransplantation trials. However, as these humoral immune ba...
Source: Journal of Immunology Research - November 23, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

The Application of Dextran Sedimentation as an Initial Step in Neutrophil Purification Promotes Their Stimulation, due to the Presence of Monocytes.
Authors: Quach A, Ferrante A Abstract The purification of human neutrophils for in vitro studies is challenging as they are easily activated through ex vivo manipulations. The technique of erythrocyte sedimentation combined with density gradient centrifugation remains widely practiced and was the subject of this study. Since in the sedimentation step the leukocytes are incubated with dextran, we have raised the likelihood that cellular activation would occur with mediator release leading to neutrophil activation. By comparing the activity of neutrophils purified from whole blood by the classical 2-step method of de...
Source: Journal of Immunology Research - November 23, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

New Insights into the Mechanisms of Chinese Herbal Products on Diabetes: A Focus on the "Bacteria-Mucosal Immunity-Inflammation-Diabetes" Axis.
New Insights into the Mechanisms of Chinese Herbal Products on Diabetes: A Focus on the "Bacteria-Mucosal Immunity-Inflammation-Diabetes" Axis. J Immunol Res. 2017;2017:1813086 Authors: Gao Z, Li Q, Wu X, Zhao X, Zhao L, Tong X Abstract Diabetes, especially type 2, has been rapidly increasing all over the world. Although many drugs have been developed and used to treat diabetes, side effects and long-term efficacy are of great challenge. Therefore, natural health product and dietary supplements have been of increasing interest alternatively. In this regard, Chinese herbs and herbal products h...
Source: Journal of Immunology Research - November 23, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Decitabine-Induced Changes in Human Myelodysplastic Syndrome Cell Line SKM-1 Are Mediated by FOXO3A Activation.
Authors: Zeng W, Dai H, Yan M, Cai X, Luo H, Ke M, Liu Z Abstract The epigenetic silencing of tumor suppressor genes in myelodysplastic syndromes (MDS) can potentially confer a growth advantage to individual cellular clones. Currently, the recommended treatment for patients with high-risk MDS is the methylation agent decitabine (DAC), a drug that can induce the reexpression of silenced tumor suppressor genes. We investigated the effects of DAC treatment on the myeloid MDS cell line SKM-1 and investigated the role of FOXO3A, a potentially tumor-suppressive transcription factor, by silencing its expression prior to D...
Source: Journal of Immunology Research - November 12, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

An Exploration of the Impact of Anticentromere Antibody on Early-Stage Embryo.
Conclusion: Mouse embryos may be a direct target for ACA in vitro prior to implantation. However, the precise mechanism needs further clarification. PMID: 29119119 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - November 10, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Computer-Aided Design of an Epitope-Based Vaccine against Epstein-Barr Virus.
Authors: Alonso-Padilla J, Lafuente EM, Reche PA Abstract Epstein-Barr virus is a very common human virus that infects 90% of human adults. EBV replicates in epithelial and B cells and causes infectious mononucleosis. EBV infection is also linked to various cancers, including Burkitt's lymphoma and nasopharyngeal carcinomas, and autoimmune diseases such as multiple sclerosis. Currently, there are no effective drugs or vaccines to treat or prevent EBV infection. Herein, we applied a computer-aided strategy to design a prophylactic epitope vaccine ensemble from experimentally defined T and B cell epitopes. Such strat...
Source: Journal of Immunology Research - November 10, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Cytokine Profile of Patients with Allergic Rhinitis Caused by Pollen, Mite, and Microbial Allergen Sensitization.
Authors: Tyurin YA, Lissovskaya SA, Fassahov RS, Mustafin IG, Shamsutdinov AF, Shilova MA, Rizvanov AA Abstract Allergic rhinitis (AR) is especially prevalent among the population of large cities. Immunologically, the airway epithelium is a region where the population of allergen-presenting cells concentrates. These cells actively express a group of receptors of the innate immune system. A specific cytokine profile is its representation. The study was aimed at evaluating the cytokine profile in patients with seasonal and perennial allergic rhinitis. The cytokine profile of nasal secretion and blood serum of 44 pati...
Source: Journal of Immunology Research - November 9, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Immunotherapy as a Promising Treatment for Prostate Cancer: A Systematic Review.
Authors: Janiczek M, Szylberg Ł, Kasperska A, Kowalewski A, Parol M, Antosik P, Radecka B, Marszałek A Abstract Prostate cancer treatment is currently based on surgical removal, radiotherapy, and hormone therapy. In recent years, another therapeutic method has emerged-immunological treatment. Immunotherapy modulates and strengthens one's immune responses against cancer. Neoplastic cells naturally escape from the control of the immune system, and the main goal of immune therapy is to bring the control back. Satisfying outcomes after treatment of advanced melanoma and lung cancer suggest a great potential of immuno...
Source: Journal of Immunology Research - November 9, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

A Novel System for the Quantification of the ADCC Activity of Therapeutic Antibodies.
Authors: Lallemand C, Liang F, Staub F, Simansour M, Vallette B, Huang L, Ferrando-Miguel R, Tovey MG Abstract Novel ADCC effector cells expressing the V-variant or F-variant of FcγRIIIa (CD16a) and firefly luciferase under the control of a chimeric promoter incorporating recognition sequences for the principal transcription factors involved in FcγRIIIa signal transduction, together with novel target cells overexpressing a constant high level of the specific antigen recognized by rituximab, trastuzumab, cetuximab, infliximab, adalimumab, or etanercept, confer improved sensitivity, specificity, and dynam...
Source: Journal of Immunology Research - November 8, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Maternal and Perinatal Outcome in Women with Systemic Lupus Erythematosus: A Retrospective Bicenter Cohort Study.
Conclusion: In this SLE population with low disease activity, pregnancy complications were present irrespective of antiphospholipid antibody status. Furthermore, there were no differences in complication rates between the first and consecutive pregnancies as seen in healthy mothers. This information is useful for patient counseling. PMID: 29094052 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - November 3, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

The Hydroalcoholic Extract Obtained from Mentha piperita L. Leaves Attenuates Oxidative Stress and Improves Survival in Lipopolysaccharide-Treated Macrophages.
Authors: Arruda MO, Mendes SJF, Teixeira SA, de Mesquita LSS, de Sousa Ribeiro MN, Galvão SSL, Muscará MN, Fernandes ES, Monteiro-Neto V Abstract Mentha piperita L. (peppermint) possesses antimicrobial properties, but little is known of its ability to modulate macrophages. Macrophages are essential in bacterial infection control due to their antimicrobial functions and ability to link the innate and adaptive immune responses. We evaluated the effects of the peppermint leaf hydroalcoholic extract (LHAE) on cultured murine peritoneal macrophages stimulated or not with lipopolysaccharide (LPS) in vitro. ...
Source: Journal of Immunology Research - November 2, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Vaccinomics Approach for Designing Potential Peptide Vaccine by Targeting Shigella spp. Serine Protease Autotransporter Subfamily Protein SigA.
Authors: Oany AR, Pervin T, Mia M, Hossain M, Shahnaij M, Mahmud S, Kibria KMK Abstract Shigellosis, a bacillary dysentery, is closely associated with diarrhoea in human and causes infection of 165 million people worldwide per year. Casein-degrading serine protease autotransporter of enterobacteriaceae (SPATE) subfamily protein SigA, an outer membrane protein, exerts both cytopathic and enterotoxic effects especially cytopathic to human epithelial cell type-2 (HEp-2) and is shown to be highly immunogenic. In the present study, we have tried to impose the vaccinomics approach for designing a common peptide vaccine c...
Source: Journal of Immunology Research - October 31, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Dendritic Cells in Sepsis: Pathological Alterations and Therapeutic Implications.
Authors: Wu DD, Li T, Ji XY Abstract Sepsis is the leading cause of death for critically ill patients in recent years. Dendritic cells (DCs) are important antigen-presenting cells and play a key role in immune response by regulating the innate and adaptive immunity. The number of DCs, the differentiation of monocytes into DCs, and the levels of surface molecules associated with the function of DCs are changed in the development of sepsis. There are many mechanisms involved in the alterations of DCs during sepsis, including the induction of apoptosis, reactive oxygen species generation, activation of the Wnt signali...
Source: Journal of Immunology Research - October 29, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Enavatuzumab, a Humanized Anti-TWEAK Receptor Monoclonal Antibody, Exerts Antitumor Activity through Attracting and Activating Innate Immune Effector Cells.
Authors: Ye S, Fox MI, Belmar NA, Sho M, Chao DT, Choi D, Fang Y, Zhao V, Keller SF, Starling GC, Culp PA Abstract Enavatuzumab is a humanized IgG1 anti-TWEAK receptor monoclonal antibody that was evaluated in a phase I clinical study for the treatment of solid malignancies. The current study was to determine whether and how myeloid effector cells were involved in postulated mechanisms for its potent antitumor activity in xenograft models. The initial evidence for a role of effector cells was obtained in a subset of tumor xenograft mouse models whose response to enavatuzumab relied on the binding of Fc of the antib...
Source: Journal of Immunology Research - October 29, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Propyl Gallate Exerts an Antimigration Effect on Temozolomide-Treated Malignant Glioma Cells through Inhibition of ROS and the NF- κB Pathway.
In this study, we demonstrated that temozolomide (TMZ) and propyl gallate (PG) combination enhanced the inhibition of migration in human U87MG glioma cells. PG inhibited the TMZ-induced reactive oxygen species (ROS) generation. The mitochondrial complex III and NADPH oxidase are two critical sites that can be considered to regulate antimigration in TMZ-treated U87MG cells. PG can enhance the antimigration effect of TMZ through suppression of metalloproteinase-2 and metalloproteinase-9 activities, ROS generation, and the NF-κB pathway and possibly provide a novel prospective strategy for treating malignant glioma. ...
Source: Journal of Immunology Research - October 26, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Traditional Chinese Medicine Protects against Cytokine Production as the Potential Immunosuppressive Agents in Atherosclerosis.
Authors: Ren Y, Qiao W, Fu D, Han Z, Liu W, Ye W, Liu Z Abstract Atherosclerosis is a chronic inflammatory disease caused by dyslipidemia and mediated by both innate and adaptive immune responses. Inflammation is a critical factor at all stages of atherosclerosis progression. Proinflammatory cytokines accelerate atherosclerosis progression, while anti-inflammatory cytokines ameliorate the disease. Accordingly, strategies to inhibit immune activation and impede immune responses towards anti-inflammatory activity are an alternative therapeutic strategy to conventional chemotherapy on cardiocerebrovascular outcomes. S...
Source: Journal of Immunology Research - October 20, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Intestinal Dysbiosis and Rheumatoid Arthritis: A Link between Gut Microbiota and the Pathogenesis of Rheumatoid Arthritis.
Authors: Horta-Baas G, Romero-Figueroa MDS, Montiel-Jarquín AJ, Pizano-Zárate ML, García-Mena J, Ramírez-Durán N Abstract Characterization and understanding of gut microbiota has recently increased representing a wide research field, especially in autoimmune diseases. Gut microbiota is the major source of microbes which might exert beneficial as well as pathogenic effects on human health. Intestinal microbiome's role as mediator of inflammation has only recently emerged. Microbiota has been observed to differ in subjects with early rheumatoid arthritis compared to controls, and th...
Source: Journal of Immunology Research - September 29, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Chinese Herbal Formula, Modified Danggui Buxue Tang, Attenuates Apoptosis of Hematopoietic Stem Cells in Immune-Mediated Aplastic Anemia Mouse Model.
In conclusion, DGBX can relieve the immune-mediated destruction of HSCs, repair hematopoietic failure, and recover the hematopoietic function of HSCs in hematogenesis. Therefore, DGBX can be used in traditional medicine against AA as a complementary and alternative immunosuppressive therapeutic formula. PMID: 28951880 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - September 29, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

In Vitro Immunomodulatory Activity of a Transition-State Analog Inhibitor of Human Purine Nucleoside Phosphorylase in Cutaneous Leishmaniasis.
Authors: Carvalho NB, de Oliveira Prates FV, da Silva RC, Dourado MEF, Amorim CF, Machado PRL, Pacheco FG, Corte TWF, Machado P, Santos DS, de Carvalho EM Abstract Cutaneous leishmaniasis (CL) is the most common clinical form of American tegumentary leishmaniasis caused by Leishmania (Viannia) braziliensis. CL is associated with a strong Th1 immune response. This exacerbated inflammatory response is correlated with severity of disease and delays the healing time of the ulcer. The fourth-generation immucillin derivative (DI4G), a potent inhibitor of purine nucleoside phosphorylase, has been proposed as a promising a...
Source: Journal of Immunology Research - September 22, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

The Humoral Theory of Transplantation.
Authors: Ravindranath MH, Cai J, Ferrone S, Claas FHJ, Selvan SR PMID: 28929124 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - September 22, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

The Differential Contribution of the Innate Immune System to a Good Pathological Response in the Breast and Axillary Lymph Nodes Induced by Neoadjuvant Chemotherapy in Women with Large and Locally Advanced Breast Cancers.
Authors: Kaewkangsadan V, Verma C, Eremin JM, Cowley G, Ilyas M, Satthaporn S, Eremin O Abstract The tumour microenvironment consists of malignant cells, stroma, and immune cells. The role of adaptive immunity in inducing a pathological complete response (pCR) in breast cancer with neoadjuvant chemotherapy (NAC) is well studied. The contribution of innate immunity, however, is poorly documented. Breast tumours and axillary lymph nodes (ALNs) from 33 women with large and locally advanced breast cancers (LLABCs) undergoing NAC were immunohistochemically assessed for tumour-infiltrating macrophages (TIMs: M1 and M2), ...
Source: Journal of Immunology Research - September 17, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research