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Proteomic Identification of Heat Shock-Induced Danger Signals in a Melanoma Cell Lysate Used in Dendritic Cell-Based Cancer Immunotherapy.
Authors: González FE, Chernobrovkin A, Pereda C, García-Salum T, Tittarelli A, López MN, Salazar-Onfray F, Zubarev RA Abstract Autologous dendritic cells (DCs) loaded with cancer cell-derived lysates have become a promising tool in cancer immunotherapy. During the last decade, we demonstrated that vaccination of advanced melanoma patients with autologous tumor antigen presenting cells (TAPCells) loaded with an allogeneic heat shock- (HS-) conditioned melanoma cell-derived lysate (called TRIMEL) is able to induce an antitumor immune response associated with a prolonged patient survival. TRIMEL p...
Source: Journal of Immunology Research - May 12, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Recent Advances in Drug-Induced Hypersensitivity Syndrome/Drug Reaction with Eosinophilia and Systemic Symptoms.
Authors: Watanabe H Abstract Drug-induced hypersensitivity syndrome (DIHS), also termed as drug reaction with eosinophilia and systemic symptoms (DRESS), is a multiorgan systemic reaction characterized by a close relationship with the reactivation of herpes virus. Published data has demonstrated that among patients with DIHS/DRESS, 75-95% have leukocytosis, 18.2-90% show atypical lymphocytes, 52-95% have eosinophilia, and 75-100% have hepatic abnormalities. Histologically, eosinophils were observed less frequently than we expected (20%). The mainstay of DIHS/DRESS treatment is a moderate dose of systemic corticoste...
Source: Journal of Immunology Research - May 12, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Adoptive Cell Therapy with Tumor-Infiltrating Lymphocytes in Advanced Melanoma Patients.
Authors: Saint-Jean M, Knol AC, Volteau C, Quéreux G, Peuvrel L, Brocard A, Pandolfino MC, Saiagh S, Nguyen JM, Bedane C, Basset-Seguin N, Khammari A, Dréno B Abstract Immunotherapy for melanoma includes adoptive cell therapy with autologous tumor-infiltrating lymphocytes (TILs). This monocenter retrospective study was undertaken to evaluate the efficacy and safety of this treatment of patients with advanced melanoma. All advanced melanoma patients treated with TILs using the same TIL expansion methodology and same treatment interleukin-2 (IL-2) regimen between 2009 and 2012 were included. After steri...
Source: Journal of Immunology Research - May 12, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Mycobacterium tuberculosis Protein Rv3841 Activates Dendritic Cells and Contributes to a T Helper 1 Immune Response.
Authors: Choi S, Choi HG, Shin KW, Back YW, Park HS, Lee JH, Kim HJ Abstract The attenuated vaccine Mycobacterium bovis BCG (Bacille Calmette Guerin) has limited protective efficacy against TB. The development of more effective TB vaccines has focused on the mycobacterial antigens that cause strong T helper 1 (Th1) responses. Mtb protein Rv3841 (bacterioferritin B; BfrB) is known to play a crucial role in the growth of Mtb. Nonetheless, it is unclear whether Rv3841 can induce protective immunity against Mtb. Here, we studied the action of Rv3841 in maturation of dendritic cells (DCs) and its engagement in the devel...
Source: Journal of Immunology Research - May 9, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Renal Evaluation in Common Variable Immunodeficiency.
Conclusion: Patients showed a trend towards an elevated prevalence of tubular dysfunction, mainly related to urinary acidification and concentration capacities. PMID: 29736405 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - May 9, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Immune Response to Rotavirus and Gluten Sensitivity.
Authors: Puccetti A, Saverino D, Opri R, Gabrielli O, Zanoni G, Pelosi A, Fiore PF, Moretta F, Lunardi C, Dolcino M Abstract Rotavirus is a double-stranded RNA virus belonging to the family of Reoviridae. The virus is transmitted by the faecal-oral route and infects intestinal cells causing gastroenteritis. Rotaviruses are the main cause of severe acute diarrhoea in children less than 5 years of age worldwide. In our previous work we have shown a link between rotavirus infection and celiac disease. Nonceliac gluten sensitivity (NCGS) is emerging as new clinical entity lacking specific diagnostic biomarkers which ha...
Source: Journal of Immunology Research - May 9, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Stimulation of Dectin-1 and Dectin-2 during Parenteral Immunization, but Not Mincle, Induces Secretory IgA in Intestinal Mucosa.
Authors: Dzharullaeva AS, Tukhvatulin AI, Erokhova AS, Bandelyuk AS, Polyakov NB, Solovyev AI, Nikitenko NA, Shcheblyakov DV, Naroditsky BS, Logunov DY, Gintsburg AL Abstract Induction of a robust and long-lived mucosal immune response during vaccination is critical to achieve protection against numerous pathogens. However, traditional injected vaccines are generally poor inducers of mucosal immunity. One of the effective strategies to improve vaccine efficacy is incorporation of adjuvant molecules that enhance and polarize adaptive immune reactions. Effects of Syk-coupled lectin receptor agonists as adjuvants to i...
Source: Journal of Immunology Research - May 8, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

The Glucagon-Like Peptide-1 Receptor Agonist Exendin-4 Inhibits Lipopolysaccharide-Induced Osteoclast Formation and Bone Resorption via Inhibition of TNF- α Expression in Macrophages.
In this study, we investigated the effect of exendin-4, a widely used GLP-1 receptor agonist, in LPS-induced osteoclast formation and bone resorption. LPS with or without exendin-4 was administered on mouse calvariae by daily subcutaneous injection. The number of osteoclasts, the ratio of bone resorption pits, and the level of C-terminal cross-linked telopeptide of type I collagen (CTX) were significantly lower in LPS- and exendin-4-coadministered mice than in mice administered with LPS alone. RANKL and TNF-α mRNA expression levels were lower in the exendin-4- and LPS-coadministered group than in the LPS-administered...
Source: Journal of Immunology Research - May 8, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Hepatitis C Infection and Periodontal Disease: Is there a Common Immunological Link?
Authors: Gheorghe DN, Foia L, Toma V, Surdu A, Herascu E, Popescu DM, Surlin P, Vere CC, Rogoveanu I Abstract Hepatitis C virus (HCV) infections could have an important impact on the oral health status of patients, favoring conditions such as periodontal disease and oral cancer. The review of the existing scientific literature written in English was performed, searching for oral and periodontal manifestations of HCV infection and its impact on the oral fluids. HCV infection can determine direct extrahepatic manifestations at the oral and periodontal level including oral lichen planus, Sjögren-like sialadenitis...
Source: Journal of Immunology Research - May 8, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Immunotherapies: Exploiting the Immune System for Cancer Treatment.
Authors: Koury J, Lucero M, Cato C, Chang L, Geiger J, Henry D, Hernandez J, Hung F, Kaur P, Teskey G, Tran A Abstract Cancer is a condition that has plagued humanity for thousands of years, with the first depictions dating back to ancient Egyptian times. However, not until recent decades have biological therapeutics been developed and refined enough to safely and effectively combat cancer. Three unique immunotherapies have gained traction in recent decades: adoptive T cell transfer, checkpoint inhibitors, and bivalent antibodies. Each has led to clinically approved therapies, as well as to therapies in preclinical...
Source: Journal of Immunology Research - May 8, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Development of Safe and Non-Self-Immunogenic Mucosal Adjuvant by Recombinant Fusion of Cholera Toxin A1 Subunit with Protein Transduction Domain.
Authors: Shim BS, Cheon IS, Lee E, Park SM, Choi Y, Jung DI, Yang E, Choi JA, Chun JY, Kim JO, Yun CH, Czerkinsky C, Song MK Abstract Potential use of cholera toxin (CT) as a mucosal vaccine adjuvant has been documented in a variety of animal models. However, native CT is highly toxic to be used as a mucosal adjuvant in humans. Here, we demonstrate a new approach to generate a mucosal adjuvant by replacing the B subunit of CT with HIV-1 Tat protein transduction domain (PTD), which efficiently delivers fusion proteins into the cell cytoplasm by unspecific binding to cell surface. We compared the adjuvanticity and to...
Source: Journal of Immunology Research - May 2, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Natural Killer Cells from Malignant Pleural Effusion Are Endowed with a Decidual-Like Proangiogenic Polarization.
Authors: Bosi A, Zanellato S, Bassani B, Albini A, Musco A, Cattoni M, Desio M, Nardecchia E, D'Urso DG, Imperatori A, Dominioni L, Noonan DM, Mortara L, Bruno A Abstract Natural killer (NK) cells are crucial in tumor recognition and eradication, but their activity is impaired in cancer patients, becoming poorly cytotoxic. A particular type of NK cells, from the decidua, has low cytotoxicity and shows proangiogenic functions. We investigated whether NK cells from peripheral blood (PB) and pleural effusions of patients develop decidual-like NK phenotype and whether exposure to IL-2 can restore their killing ability ...
Source: Journal of Immunology Research - May 2, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Remaining Physiological Barriers in Porcine Kidney Xenotransplantation: Potential Pathways behind Proteinuria as well as Factors Related to Growth Discrepancies following Pig-to-Kidney Xenotransplantation.
Authors: Shah JA, Lanaspa MA, Tanabe T, Watanabe H, Johnson RJ, Yamada K Abstract Considerable shortages in the supply of available organs continue to plague the field of solid organ transplantation. Despite changes in allocation, as well as the utilization of extended criteria and living donors, the number of patients waiting for organs continues to grow at an alarming pace. Xenotransplantation, cross-species solid organ transplantation, offers one potential solution to this dilemma. Previous extensive research dedicated to this field has allowed for resolution of xenograft failure due to acute rejection, leaving ...
Source: Journal of Immunology Research - April 26, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Kidney Transplantation: The Challenge of Human Leukocyte Antigen and Its Therapeutic Strategies.
Authors: Alelign T, Ahmed MM, Bobosha K, Tadesse Y, Howe R, Petros B Abstract Kidney transplantation remains the treatment of choice for end-stage renal failure. When the immune system of the recipient recognizes the transplanted kidney as a foreign object, graft rejection occurs. As part of the host immune defense mechanism, human leukocyte antigen (HLA) is a major challenge for graft rejection in transplantation therapy. The impact of HLA mismatches between the donor and the potential recipient prolongs the time for renal transplantation therapy, tethered to dialysis, latter reduces graft survival, and increases ...
Source: Journal of Immunology Research - April 26, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

The Role of Flavonoids in Inhibiting Th17 Responses in Inflammatory Arthritis.
Authors: Kelepouri D, Mavropoulos A, Bogdanos DP, Sakkas LI Abstract Flavonoids have been considered powerful anti-inflammatory agents, and their exact immunomodulatory action as therapeutic agents in autoimmune diseases has started to emerge. Their role in the manipulation of immunoregulation is less understood. Several studies attempted to investigate the role of various flavonoids mainly in experimental models of autoimmune diseases, especially in the context of their potential effect on the increase of regulatory T cells (Tregs) and their ability to stimulate an overexpression of anti-inflammatory cytokines, in...
Source: Journal of Immunology Research - April 26, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Microorganisms in the Treatment of Cancer: Advantages and Limitations.
Authors: Łukasiewicz K, Fol M Abstract Cancer remains one of the major challenges of the 21st century. The increasing numbers of cases are not accompanied by adequate progress in therapy. The standard methods of treatment often do not lead to the expected effects. Therefore, it is extremely important to find new, more effective treatments. One of the most promising research directions is immunotherapy, including the use of specific types of microorganisms. This type of treatment is expected to stimulate the immune system for the selective elimination of cancer cells. The research results seem to be promising and s...
Source: Journal of Immunology Research - April 25, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Therapeutic Potential of Pien Tze Huang on Experimental Autoimmune Encephalomyelitis Rat.
This study investigated the possible therapeutic effects of PZH on experimental autoimmune encephalomyelitis (EAE) rats, a classic animal model of MS. Male Lewis rats were immunized with myelin basic protein (MBP) peptide to establish an EAE model and then treated with three doses of PZH. Clinical symptoms, organ coefficient, histopathological features, levels of proinflammatory cytokines, and chemokines as well as MBP and Olig2 were analyzed. The results indicated that PZH ameliorated the clinical severity of EAE rats. It also remarkably reduced inflammatory cell infiltration in the CNS of EAE rats. Furthermore, the level...
Source: Journal of Immunology Research - April 25, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

An Increased Frequency in HLA Class I Alleles and Haplotypes Suggests Genetic Susceptibility to Influenza A (H1N1) 2009 Pandemic: A Case-Control Study.
Authors: Falfán-Valencia R, Narayanankutty A, Reséndiz-Hernández JM, Pérez-Rubio G, Ramírez-Venegas A, Nava-Quiroz KJ, Bautista-Félix NE, Vargas-Alarcón G, Castillejos-López MDJ, Hernández A Abstract Background: The influenza A H1N1/09 pandemic infected a small number of exposed individuals, which suggests the involvement of genetic factors. There are scarce data available on classical HLA class I association with the influenza A H1N1/09 pandemic. Methods: We analyzed the frequency of classical HLA class I alleles and haplotypes in A H1N1/09 influen...
Source: Journal of Immunology Research - April 25, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Parenterally Administered Norovirus GII.4 Virus-Like Particle Vaccine Formulated with Aluminum Hydroxide or Monophosphoryl Lipid A Adjuvants Induces Systemic but Not Mucosal Immune Responses in Mice.
Authors: Heinimäki S, Malm M, Vesikari T, Blazevic V Abstract Norovirus (NoV) is a main cause of acute gastroenteritis across all ages worldwide. NoV vaccine candidates currently in clinical trials are based on noninfectious highly immunogenic virus-like particles (VLPs) delivered intramuscularly (IM). Since NoV is an enteric pathogen, it is likely that mucosal immunity has a significant role in protection from infection in the intestine. Due to the fact that IM delivery of NoV VLPs does not generate mucosal immunity, we investigated whether NoV genotype GII.4 VLPs coadministered with aluminum hydroxide (Al(OH...
Source: Journal of Immunology Research - April 25, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Hepatitis B Vaccination Induced TNF- α- and IL-2-Producing T Cell Responses in HIV- Healthy Individuals Higher than in HIV+ Individuals Who Received the Same Vaccination Regimen.
Hepatitis B Vaccination Induced TNF-α- and IL-2-Producing T Cell Responses in HIV- Healthy Individuals Higher than in HIV+ Individuals Who Received the Same Vaccination Regimen. J Immunol Res. 2018;2018:8350862 Authors: Chawansuntati K, Chaiklang K, Chaiwarith R, Praparattanapan J, Supparatpinyo K, Wipasa J Abstract We investigated cytokine production and expression of degranulation marker CD107a after different strategies of hepatitis B virus (HBV) vaccination in human immunodeficiency virus-infected individuals, which were three doses of 20 μg (standard dose group), four doses of 20&t...
Source: Journal of Immunology Research - April 25, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Prevention and Treatment of Osteoporosis Using Chinese Medicinal Plants: Special Emphasis on Mechanisms of Immune Modulation.
Authors: Zhao H, Zhao N, Zheng P, Xu X, Liu M, Luo D, Xu H, Ju D Abstract Numerous studies have examined the pathogenesis of osteoporosis. The causes of osteoporosis include endocrine factors, nutritional status, genetic factors, physical factors, and immune factors. Recent osteoimmunology studies demonstrated that the immune system and immune factors play important regulatory roles in the occurrence of osteoporosis, and people should pay more attention to the relationship between immunity and osteoporosis. Immune and bone cells are located in the bone marrow and share numerous regulatory molecules, signaling molec...
Source: Journal of Immunology Research - April 22, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Punica granatum L. Leaf Extract Attenuates Lung Inflammation in Mice with Acute Lung Injury.
Authors: Pinheiro AJMCR, Gonçalves JS, Dourado ÁWA, de Sousa EM, Brito NM, Silva LK, Batista MCA, de Sá JC, Monteiro CRAV, Fernandes ES, Monteiro-Neto V, Campbell LA, Zago PMW, Lima-Neto LG Abstract The hydroalcoholic extract of Punica granatum (pomegranate) leaves was previously demonstrated to be anti-inflammatory in a rat model of lipopolysaccharide- (LPS-) induced acute peritonitis. Here, we investigated the anti-inflammatory effects of the ethyl acetate fraction obtained from the pomegranate leaf hydroalcoholic extract (EAFPg) on the LPS-induced acute lung injury (ALI) mouse model. Male Sw...
Source: Journal of Immunology Research - April 22, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

FGFRL1 Promotes Ovarian Cancer Progression by Crosstalk with Hedgehog Signaling.
Authors: Tai H, Wu Z, Sun S, Zhang Z, Xu C Abstract Fibroblast growth factor receptor-like-1 (FGFRL1) has been identified as the fifth fibroblast growth factor receptor. So far, little is known about its biological functions, particularly in cancer development. Here, for the first time, we demonstrated the roles of FGFRL1 in ovarian carcinoma (OC). An array and existing databases were used to investigate the expression profile of FGFRL1 and the relationship between FGFRL1 expression and clinicopathological parameters. FGFRL1 was significantly upregulated in OC patients, and high FGFRL1 expression was correlated wit...
Source: Journal of Immunology Research - April 22, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Response to: Comment on "New Alternatives for Autoimmune Disease Treatments: Physicochemical and Clinical Comparability of Biosimilar Etanercept".
Response to: Comment on "New Alternatives for Autoimmune Disease Treatments: Physicochemical and Clinical Comparability of Biosimilar Etanercept". J Immunol Res. 2018;2018:6156024 Authors: Miranda-Hernández MP, López-Morales CA, Perdomo-Abúndez FC, Salazar-Flores RD, Ramírez-Ibanez ND, Pérez NO, Molina-Pérez A, Revilla-Beltri J, Medina-Rivero E, Flores-Ortiz LF PMID: 29676408 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - April 22, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Management of Patients with Graves' Disease and Orbital Involvement: Role of Spectral Domain Optical Coherence Tomography.
Authors: Bruscolini A, La Cava M, Gharbiya M, Sacchetti M, Restivo L, Nardella C, Marenco M, Lambiase A Abstract Purpose: To investigate the role of choroidal thickness evaluation with spectral domain optical coherence tomography (SDOCT) and enhanced depth imaging (EDI) technique in the management of patients with Graves' disease and orbitopathy (GO). Methods: Thirty-six eyes of 18 patients with GO and 36 eyes of 18 age-matched control subjects were included in this retrospective observational study. All the subjects underwent a complete ophthalmological evaluation, including clinical activity score (CAS) and e...
Source: Journal of Immunology Research - April 21, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Dysregulated Functions of Lung Macrophage Populations in COPD.
Authors: Kapellos TS, Bassler K, Aschenbrenner AC, Fujii W, Schultze JL Abstract Chronic obstructive pulmonary disease (COPD) is a diverse respiratory disease characterised by bronchiolitis, small airway obstruction, and emphysema. Innate immune cells play a pivotal role in the disease's progression, and in particular, lung macrophages exploit their prevalence and strategic localisation to orchestrate immune responses. To date, alveolar and interstitial resident macrophages as well as blood monocytes have been described in the lungs of patients with COPD contributing to disease pathology by changes in their functio...
Source: Journal of Immunology Research - April 21, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Methotrexate Combined with 4-Hydroperoxycyclophosphamide Downregulates Multidrug-Resistance P-Glycoprotein Expression Induced by Methotrexate in Rheumatoid Arthritis Fibroblast-Like Synoviocytes via the JAK2/STAT3 Pathway.
Conclusions: The increased anti-P-gp effect of MTX + 4-HC versus MTX alone in RA-FLSs was mediated via inhibition of the JAK2/STAT3 pathway and may have helped reverse MDR in refractory RA patients with high-P-gp levels. PMID: 29670920 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - April 21, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Roles of Macrophage Subtypes in Bowel Anastomotic Healing and Anastomotic Leakage.
Authors: Shi J, Wu Z, Li Z, Ji J Abstract Macrophages play an important role in host defense, in addition to the powerful ability to phagocytose pathogens or foreign matters. They fulfill a variety of roles in immune regulation, wound healing, and tissue homeostasis preservation. Macrophages are characterized by high heterogeneity, which can polarize into at least two major extremes, M1-type macrophages (classical activation) which are normally derived from monocytes and M2-type macrophages (alternative activation) which are mostly those tissue-resident macrophages. Based on the wound healing process in skin, the p...
Source: Journal of Immunology Research - April 21, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Clinicopathological Features and Increased Expression of Toll-Like Receptor 4 of Gastric Cardia Cancer in a High-Risk Chinese Population.
Authors: Chen G, Xu M, Chen J, Hong L, Lin W, Zhao S, Zhang G, Dan G, Liu S Abstract The incidence of gastric cardia cancer (GCC) is high in China. However, the clinicopathological characteristics and the carcinogenesis of GCC are unclear. Toll-like receptor 4 (TLR4) is an important innate immunity receptor and has a role in non-GCC (NGCC). We compared the clinicopathological characteristics of GCC patients from a high-risk area in China to esophageal cancer (EC) patients. Immunohistochemistry for TLR4 was performed in 201 histological samples of normal gastric cardia mucosa (n = 11), gastric cardia inflammation (n...
Source: Journal of Immunology Research - April 21, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Cathelicidin LL-37 Affects Surface and Intracellular Toll-Like Receptor Expression in Tissue Mast Cells.
We examined the impact of human cathelicidin LL-37 on tissue mast cell TLR expression and distribution. Depending on context, we show that LL-37 stimulation resulted in minor to major effects on TLR2, TLR3, TLR4, TLR5, TLR7, and TLR9 expression. Confocal microscopy analysis showed that, upon stimulation, TLRs may translocate from the cell interior to the surface and conversely. FPR2 and EGFR inhibitors reduced the increase in expression of selected receptors. We also established that LL-37 acts as a powerful inducer of CCL3 and ROS generation. These results showed that in response to LL-37, mast cells enhance the capabilit...
Source: Journal of Immunology Research - April 21, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Mast Cell, the Neglected Member of the Tumor Microenvironment: Role in Breast Cancer.
Authors: Aponte-López A, Fuentes-Pananá EM, Cortes-Muñoz D, Muñoz-Cruz S Abstract Mast cells are unique tissue-resident immune cells that secrete a diverse array of biologically active compounds that can stimulate, modulate, or suppress the immune response. Although mounting evidence supports that mast cells are consistently infiltrating tumors, their role as either a driving or an opposite force for cancer progression is still controversial. Particularly, in breast cancer, their function is still under discussion. While some studies have shown a protective role, recent evidence indicate...
Source: Journal of Immunology Research - April 16, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

STAT1, IGF1, RAC1, and MDM2 Are Associated with Recurrence of Giant Cell Tumor of Bone.
Authors: Chen S, Du Z, Wu B, Shen H, Liu C, Qiu X, Zhang Y, Xu L, Li E, Zhong Z Abstract Background: In our previous study, mouse double minute 2 homolog (MDM2), insulin-like growth factor 1 (IGF1), signal transducer and activator of transcription 1 (STAT1), and Rac family small GTPase 1 (RAC1) were correlated with the recurrence of giant cell tumor of bone (GCT). The aim of this study is to use a large cohort study to confirm the involvement of these four genes in GCT recurrence. Methods: The expression of these four genes was detected and compared between GCT patients with or without recurrence. The correlati...
Source: Journal of Immunology Research - April 16, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Comment on "New Alternatives for Autoimmune Disease Treatments: Physicochemical and Clinical Comparability of Biosimilar Etanercept".
Comment on "New Alternatives for Autoimmune Disease Treatments: Physicochemical and Clinical Comparability of Biosimilar Etanercept". J Immunol Res. 2018;2018:5047067 Authors: Hassett B, Vicik S, Fitzpatrick B PMID: 29651442 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - April 16, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Immature Dendritic Cell Therapy Confers Durable Immune Modulation in an Antigen-Dependent and Antigen-Independent Manner in Nonobese Diabetic Mice.
Authors: Lo J, Xia CQ, Peng R, Clare-Salzler MJ Abstract Dendritic cell (DC) immunotherapy has been effective for prevention of type 1 diabetes (T1D) in NOD mice but fails to protect if initiated after active autoimmunity. As autoreactivity expands inter- and intramolecularly during disease progression, we investigated whether DCs unpulsed or pulsed with β cell antigenic dominant determinants (DD), subdominant determinants (SD), and ignored determinants (ID) could prevent T1D in mice with advanced insulitis. We found that diabetes was significantly delayed by DC therapy. Of interest, DCs pulsed with SD or ID a...
Source: Journal of Immunology Research - April 16, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

An Updated Review of the Molecular Mechanisms in Drug Hypersensitivity.
Authors: Chen CB, Abe R, Pan RY, Wang CW, Hung SI, Tsai YG, Chung WH Abstract Drug hypersensitivity may manifest ranging from milder skin reactions (e.g., maculopapular exanthema and urticaria) to severe systemic reactions, such as anaphylaxis, drug reactions with eosinophilia and systemic symptoms (DRESS)/drug-induced hypersensitivity syndrome (DIHS), or Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN). Current pharmacogenomic studies have made important strides in the prevention of some drug hypersensitivity through the identification of relevant genetic variants, particularly for genes encoding dr...
Source: Journal of Immunology Research - April 16, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Regulation of Immune Cell Functions by Metabolic Reprogramming.
Authors: Kim J Abstract Recent findings show that the metabolic status of immune cells can determine immune responses. Metabolic reprogramming between aerobic glycolysis and oxidative phosphorylation, previously speculated as exclusively observable in cancer cells, exists in various types of immune and stromal cells in many different pathological conditions other than cancer. The microenvironments of cancer, obese adipose, and wound-repairing tissues share common features of inflammatory reactions. In addition, the metabolic changes in macrophages and T cells are now regarded as crucial for the functional plasticit...
Source: Journal of Immunology Research - April 16, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Autoimmunity in Reproductive Health and Pregnancy.
Authors: Tabarkiewicz J, Selvan SR, Cools N PMID: 29651446 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - April 16, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Impaired Gal-9 Dysregulates the PBMC-Induced Th1/Th2 Imbalance in Abortion-Prone Matings.
In conclusion, our results suggest that the Gal-9 signal is important for the regulation of PBMC function toward a Th2 bias at the maternal-fetal interface, which is beneficial for the maintenance of a normal pregnancy. PMID: 29651447 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - April 16, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

The Epidemiology of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in China.
In conclusion, carbamazepine and allopurinol were the leading causative drugs for SJS/TEN in China. Combination of IVIG and steroids is a common treatment for TEN, but its efficacy in improving mortality needs further investigation. PMID: 29607330 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - April 4, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Receptors That Inhibit Macrophage Activation: Mechanisms and Signals of Regulation and Tolerance.
Authors: Ocaña-Guzman R, Vázquez-Bolaños L, Sada-Ovalle I Abstract A variety of receptors perform the function of attenuating or inhibiting activation of cells in which they are expressed. Examples of these kinds of receptors include TIM-3 and PD-1, among others that have been widely studied in cells of lymphoid origin and, though to a lesser degree, in other cell lines. Today, several studies describe the function of these molecules as part of the diverse mechanisms of immune tolerance that exist in the immune system. This review analyzes the function of some of these proteins in monocytes and...
Source: Journal of Immunology Research - April 4, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Beneficial Effects of Human Mesenchymal Stromal Cells on Porcine Hepatocyte Viability and Albumin Secretion.
Authors: Montanari E, Pimenta J, Szabó L, Noverraz F, Passemard S, Meier RPH, Meyer J, Sidibe J, Thomas A, Schuurman HJ, Gerber-Lemaire S, Gonelle-Gispert C, Buhler LH Abstract Porcine hepatocytes transplanted during acute liver failure might support metabolic functions until the diseased liver recovers its function. Here, we isolated high numbers of viable pig hepatocytes and evaluated hepatocyte functionality after encapsulation. We further investigated whether coculture and coencapsulation of hepatocytes with human multipotent mesenchymal stromal cells (MSC) are beneficial on hepatocyte function. Livers f...
Source: Journal of Immunology Research - March 27, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

How Hippo Signaling Pathway Modulates Cardiovascular Development and Diseases.
Authors: Zhou W, Zhao M Abstract Cardiovascular disease remains the leading cause of death around the globe. Cardiac deterioration is associated with irreversible cardiomyocyte loss. Understanding how the cardiovascular system develops and the pathological processes of cardiac disease will contribute to finding novel and preventive therapeutic methods. The canonical Hippo tumor suppressor pathway in mammalian cells is primarily composed of the MST1/2-SAV1-LATS1/2-MOB1-YAP/TAZ cascade. Continuing research on this pathway has identified other factors like RASSF1A, Nf2, MAP4Ks, and NDR1/2, further enriching our knowle...
Source: Journal of Immunology Research - March 27, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Leaf-Encapsulated Vaccines: Agroinfiltration and Transient Expression of the Antigen Staphylococcal Endotoxin B in Radish Leaves.
Authors: Liu PF, Wang Y, Ulrich RG, Simmons CW, VanderGheynst JS, Gallo RL, Huang CM Abstract Transgene introgression is a major concern associated with transgenic plant-based vaccines. Agroinfiltration can be used to selectively transform nonreproductive organs and avoid introgression. Here, we introduce a new vaccine modality in which Staphylococcal enterotoxin B (SEB) genes are agroinfiltrated into radishes (Raphanw sativus L.), resulting in transient expression and accumulation of SEB in planta. This approach can simultaneously express multiple antigens in a single leaf. Furthermore, the potential of high-throu...
Source: Journal of Immunology Research - March 27, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

The Influence of Genetic Variations in the CD86 Gene on the Outcome after Allogeneic Hematopoietic Stem Cell Transplantation.
Authors: Karabon L, Markiewicz M, Chrobot K, Dzierzak-Mietla M, Pawlak-Adamska E, Partyka A, Koclega A, Kyrcz-Krzemien S, Frydecka I Abstract CD86 molecule is the ligand for both costimulatory (CD28) and coinhibitory (CTLA-4) molecules, and it regulates immune response after allogeneic hematopoietic stem cell transplantation (alloHSCT). Therefore, we postulate that CD86 gene variations might influence the outcome after alloHSCT. Altogether, 295 adult patients (pts) undergoing related (105 pts) and unrelated (190 pts) donor-matched HSCT were genotyped for the following CD86 gene polymorphisms: rs1129055, rs9831894, ...
Source: Journal of Immunology Research - March 27, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Anticancer Drugs Induced Severe Adverse Cutaneous Drug Reactions: An Updated Review on the Risks Associated with Anticancer Targeted Therapy or Immunotherapies.
Authors: Ng CY, Chen CB, Wu MY, Wu J, Yang CH, Hui RC, Chang YC, Lu CW Abstract Cutaneous adverse drug reactions are commonly seen in patients with anticancer drug treatment. Anticancer drugs, including chemotherapy, target therapy, and recent immunotherapy causing skin reactions ranging from mild skin rash to life-threatening severe cutaneous adverse reactions (SCARs), such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrosis (TEN) with increase morbidity and mortality while they are receiving cancer treatments, have been proposed to be a result of direct skin toxicity or drug hypersensitivity reactions ...
Source: Journal of Immunology Research - March 27, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Aspergillus fumigatus Infection-Induced Neutrophil Recruitment and Location in the Conducting Airway of Immunocompetent, Neutropenic, and Immunosuppressed Mice.
Authors: Shevchenko MA, Bogorodskiy AO, Troyanova NI, Servuli EA, Bolkhovitina EL, Büldt G, Fahlke C, Gordeliy VI, Gensch T, Borshchevskiy VI, Sapozhnikov AM Abstract Susceptibility to fungal infection is commonly associated with impaired neutrophil responses. To study the mechanisms underlying this association, we investigated neutrophil recruitment to the conducting airway wall after Aspergillus fumigatus conidium inhalation in mouse models of drug-induced immunosuppression and antibody-mediated neutrophil depletion (neutropenia) by performing three-dimensional confocal laser-scanning microscopy of whole-mou...
Source: Journal of Immunology Research - March 27, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Frequency of Interferon-Resistance Conferring Substitutions in Amino Acid Positions 70 and 91 of Core Protein of the Russian HCV 1b Isolates Analyzed in the T-Cell Epitopic Context.
Authors: Kichatova VS, Kyuregyan KK, Soboleva NV, Karlsen AA, Isaeva OV, Isaguliants MG, Mikhailov MI Abstract Amino acid substitutions R70Q/H and L91M in HCV subtype 1b core protein can affect the response to interferon and are associated with the development of hepatocellular carcinoma. We found that the rate of R70Q/H in HCV 1b from Russia was 31.2%, similar to that in HCV strains from Asia (34.0%), higher than that in the European (18.0%, p = 0.0010), but lower than that in the US HCV 1b strains (62.8%, p
Source: Journal of Immunology Research - March 27, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Hsa_circ_0001859 Regulates ATF2 Expression by Functioning as an MiR-204/211 Sponge in Human Rheumatoid Arthritis.
Discussion: These findings indicate that hsa_circ_0001859 participates deeply in the process of chronic inflammatory disease in synovial tissue. PMID: 29577053 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - March 27, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Association between HLA-B Alleles and Carbamazepine-Induced Maculopapular Exanthema and Severe Cutaneous Reactions in Thai Patients.
Authors: Sukasem C, Chaichan C, Nakkrut T, Satapornpong P, Jaruthamsophon K, Jantararoungtong T, Koomdee N, Sririttha S, Medhasi S, Oo-Puthinan S, Rerkpattanapipat T, Klaewsongkram J, Rerknimitr P, Tuchinda P, Chularojanamontri L, Tovanabutra N, Puangpetch A, Aekplakorn W Abstract The HLA-B∗15:02 allele has been reported to have a strong association with carbamazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) in Thai patients. The HLA-B alleles associated with carbamazepine-induced maculopapular exanthema (MPE) and the drug reaction with eosinophilia and systemic symptoms (DRESS) ...
Source: Journal of Immunology Research - March 19, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Matrine Ameliorates Colorectal Cancer in Rats via Inhibition of HMGB1 Signaling and Downregulation of IL-6, TNF- α, and HMGB1.
Matrine Ameliorates Colorectal Cancer in Rats via Inhibition of HMGB1 Signaling and Downregulation of IL-6, TNF-α, and HMGB1. J Immunol Res. 2018;2018:5408324 Authors: Fan H, Jiang C, Zhong B, Sheng J, Chen T, Chen Q, Li J, Zhao H Abstract Matrine may be protective against colorectal cancer (CRC), but how it may work is unclear. Thus, we explored the underlying mechanisms of matrine in CRC. Matrine-related proteins and CRC-related genes and therapeutic targets of matrine in CRC were predicted using a network pharmacology approach. Five targets, including interleukin 6 (IL-6), the 26S proteasome, ...
Source: Journal of Immunology Research - March 19, 2018 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research