Induction Chemotherapy with FOLFIRINOX for Locally Advanced Pancreatic Cancer: A Simple Scoring System to Predict Effect and Prognosis
CONCLUSIONS: Tumor density is a novel predictive marker for the prognosis of patients with resected LAPC after FOLFIRINOX. A simple scoring model incorporating tumor density, the tumor shrinkage rate, and CA 19-9 levels identifies patients with a low score, who may be candidates for additional treatment.PMID:36153440 | DOI:10.1245/s10434-022-12569-y (Source: Ann Oncol)
Source: Ann Oncol - September 24, 2022 Category: Cancer & Oncology Authors: Masayuki Tanaka Max Heckler Andr é L Mihaljevic Shigenori Ei Ulla Klaiber Ulrike Heger Markus W B üchler Thilo Hackert Source Type: research

ASO Author Reflections: Intraoperative Anticancer Therapy for Resected Gastric Cancer
Ann Surg Oncol. 2022 Sep 24. doi: 10.1245/s10434-022-12520-1. Online ahead of print.NO ABSTRACTPMID:36153441 | DOI:10.1245/s10434-022-12520-1 (Source: Ann Oncol)
Source: Ann Oncol - September 24, 2022 Category: Cancer & Oncology Authors: Shouki Bazarbashi Source Type: research

Who Are We Missing: Does Engagement in Patient-Reported Outcome Measures for Breast Cancer Vary by Age, Race, or Disease Stage?
CONCLUSIONS: Our findings demonstrate high patient engagement using 2 different PROM following breast surgery, but suggest that PROM results may not reflect the experience of the entire breast cancer population. Care process changes based solely on PROM should consider these findings to ensure that the views of the entire spectrum of patients with breast cancer are represented.PMID:36149608 | DOI:10.1245/s10434-022-12477-1 (Source: Ann Oncol)
Source: Ann Oncol - September 23, 2022 Category: Cancer & Oncology Authors: Marissa K Srour Audree B Tadros Varadan Sevilimedu Jonas A Nelson Jennifer R Cracchiolo Taylor M McCready Nicholas Silva Tracy-Ann Moo Monica Morrow Source Type: research

Patient-Reported Outcome Measures for Patients Who Have Clinical T4 Breast Cancer Treated via Mastectomy with and Without Reconstruction
CONCLUSIONS: The patients with T4 breast cancer who elected reconstruction did not differ in patient-reported outcomes based on timing of reconstruction. In the DR cohort, SATBR significantly improved after reconstructive surgery. These data can help inform breast reconstructive decision-making for patients facing the choice among DR, IR, and NR.PMID:36149609 | DOI:10.1245/s10434-022-12560-7 (Source: Ann Oncol)
Source: Ann Oncol - September 23, 2022 Category: Cancer & Oncology Authors: Emily Palmquist Jessica Limberg Jacqueline J Chu Charlie White Raymond E Baser Varadan Sevilimedu Kate R Pawloski Paula Garcia Jonas A Nelson Tracy-Ann Moo Monica Morrow Audree B Tadros Source Type: research

Dynamic Alteration in HLA-E Expression and Soluble HLA-E via Interaction with Natural Killer Cells in Gastric Cancer
CONCLUSIONS: HLA-E expression dynamically changes on GC cells and in conditioned medium. Furthermore, soluble HLA-E can contribute to immune escape in GC cell lines, which may have significance in clinical practice. Moreover, soluble HLA-E may be a potential prognostic biomarker.PMID:36149610 | DOI:10.1245/s10434-022-12505-0 (Source: Ann Oncol)
Source: Ann Oncol - September 23, 2022 Category: Cancer & Oncology Authors: Takeshi Morinaga Masaaki Iwatsuki Kohei Yamashita Noriko Yasuda-Yoshihara Taishi Yamane Chihiro Matsumoto Kazuto Harada Kojiro Eto Junji Kurashige Takatsugu Ishimoto Yoshifumi Baba Yuji Miyamoto Naoya Yoshida Hideo Baba Source Type: research

Disparities in Care Access to Liver-Directed Therapy Among Medicare Beneficiaries with Colorectal Cancer Liver Metastasis
CONCLUSIONS: Despite the well-accepted role of LDT for CRCLM, only a small proportion of Medicare beneficiaries with CRCLM receive LDT. Increasing access to specialized centers with expertise in LDT, particularly for Black patients, female patients, and those with higher levels of social vulnerability or long travel distances, may improve outcomes for patients with CRCLM.PMID:36149611 | DOI:10.1245/s10434-022-12513-0 (Source: Ann Oncol)
Source: Ann Oncol - September 23, 2022 Category: Cancer & Oncology Authors: Christopher T Aquina Zachary J Brown Joal D Beane Aslam Ejaz Jordan M Cloyd Allan Tsung Mohamed O Adam Timothy M Pawlik Alex C Kim Source Type: research

ASO Visual Abstract: Very Early Recurrence After Curative-Intent Surgery for Gastric Adenocarcinoma
Ann Surg Oncol. 2022 Sep 23. doi: 10.1245/s10434-022-12576-z. Online ahead of print.NO ABSTRACTPMID:36151428 | DOI:10.1245/s10434-022-12576-z (Source: Ann Oncol)
Source: Ann Oncol - September 23, 2022 Category: Cancer & Oncology Authors: Gaya Spolverato Giulia Capelli Valentina Mari Giulia Lorenzoni Dario Gregori George Poultsides Ryan C Fields Sharon M Weber Konstantinos Votanopoulos Clifford S Cho Jin He Shishir K Maithel Salvatore Pucciarelli Timothy M Pawlik Source Type: research

Hyperthermic Intrathoracic Chemotherapy (HITHOC) for Pleural Disseminated Thymoma: A Systematic Literature Review
CONCLUSION: Combining cytoreductive surgery and HITHOC is feasible and safe for TPD. The strong heterogeneity in the literature impedes proper outcome analysis. More research is needed to better understand the additional benefit of HITHOC in the TPD setting.PMID:36151429 | DOI:10.1245/s10434-022-12461-9 (Source: Ann Oncol)
Source: Ann Oncol - September 23, 2022 Category: Cancer & Oncology Authors: Tom Vandaele Jan Van Slambrouck Viktor Proesmans Paul Clement Maarten Lambrecht Philippe Nafteux Dirk Van Raemdonck Laurens J Ceulemans Source Type: research

A Practical Risk Classification of Early Recurrence in Hepatocellular Carcinoma Patients with Microvascular invasion after Hepatectomy: A Decision Tree Analysis
CONCLUSIONS: The 3 stratification classifications enabled satisfactory risk evaluation of early recurrence in HCC patients with MVI after hepatectomy.PMID:36151430 | DOI:10.1245/s10434-022-12598-7 (Source: Ann Oncol)
Source: Ann Oncol - September 23, 2022 Category: Cancer & Oncology Authors: Long-Hai Feng Yu-Yao Zhu Jia-Min Zhou Miao Wang Lei Wang Wei-Qi Xu Ti Zhang An-Rong Mao Wen-Ming Cong Hui Dong Lu Wang Source Type: research

Who Are We Missing: Does Engagement in Patient-Reported Outcome Measures for Breast Cancer Vary by Age, Race, or Disease Stage?
CONCLUSIONS: Our findings demonstrate high patient engagement using 2 different PROM following breast surgery, but suggest that PROM results may not reflect the experience of the entire breast cancer population. Care process changes based solely on PROM should consider these findings to ensure that the views of the entire spectrum of patients with breast cancer are represented.PMID:36149608 | DOI:10.1245/s10434-022-12477-1 (Source: Ann Oncol)
Source: Ann Oncol - September 23, 2022 Category: Cancer & Oncology Authors: Marissa K Srour Audree B Tadros Varadan Sevilimedu Jonas A Nelson Jennifer R Cracchiolo Taylor M McCready Nicholas Silva Tracy-Ann Moo Monica Morrow Source Type: research

Patient-Reported Outcome Measures for Patients Who Have Clinical T4 Breast Cancer Treated via Mastectomy with and Without Reconstruction
CONCLUSIONS: The patients with T4 breast cancer who elected reconstruction did not differ in patient-reported outcomes based on timing of reconstruction. In the DR cohort, SATBR significantly improved after reconstructive surgery. These data can help inform breast reconstructive decision-making for patients facing the choice among DR, IR, and NR.PMID:36149609 | DOI:10.1245/s10434-022-12560-7 (Source: Ann Oncol)
Source: Ann Oncol - September 23, 2022 Category: Cancer & Oncology Authors: Emily Palmquist Jessica Limberg Jacqueline J Chu Charlie White Raymond E Baser Varadan Sevilimedu Kate R Pawloski Paula Garcia Jonas A Nelson Tracy-Ann Moo Monica Morrow Audree B Tadros Source Type: research

Dynamic Alteration in HLA-E Expression and Soluble HLA-E via Interaction with Natural Killer Cells in Gastric Cancer
CONCLUSIONS: HLA-E expression dynamically changes on GC cells and in conditioned medium. Furthermore, soluble HLA-E can contribute to immune escape in GC cell lines, which may have significance in clinical practice. Moreover, soluble HLA-E may be a potential prognostic biomarker.PMID:36149610 | DOI:10.1245/s10434-022-12505-0 (Source: Ann Oncol)
Source: Ann Oncol - September 23, 2022 Category: Cancer & Oncology Authors: Takeshi Morinaga Masaaki Iwatsuki Kohei Yamashita Noriko Yasuda-Yoshihara Taishi Yamane Chihiro Matsumoto Kazuto Harada Kojiro Eto Junji Kurashige Takatsugu Ishimoto Yoshifumi Baba Yuji Miyamoto Naoya Yoshida Hideo Baba Source Type: research

Disparities in Care Access to Liver-Directed Therapy Among Medicare Beneficiaries with Colorectal Cancer Liver Metastasis
CONCLUSIONS: Despite the well-accepted role of LDT for CRCLM, only a small proportion of Medicare beneficiaries with CRCLM receive LDT. Increasing access to specialized centers with expertise in LDT, particularly for Black patients, female patients, and those with higher levels of social vulnerability or long travel distances, may improve outcomes for patients with CRCLM.PMID:36149611 | DOI:10.1245/s10434-022-12513-0 (Source: Ann Oncol)
Source: Ann Oncol - September 23, 2022 Category: Cancer & Oncology Authors: Christopher T Aquina Zachary J Brown Joal D Beane Aslam Ejaz Jordan M Cloyd Allan Tsung Mohamed O Adam Timothy M Pawlik Alex C Kim Source Type: research

ASO Visual Abstract: Very Early Recurrence After Curative-Intent Surgery for Gastric Adenocarcinoma
Ann Surg Oncol. 2022 Sep 23. doi: 10.1245/s10434-022-12576-z. Online ahead of print.NO ABSTRACTPMID:36151428 | DOI:10.1245/s10434-022-12576-z (Source: Ann Oncol)
Source: Ann Oncol - September 23, 2022 Category: Cancer & Oncology Authors: Gaya Spolverato Giulia Capelli Valentina Mari Giulia Lorenzoni Dario Gregori George Poultsides Ryan C Fields Sharon M Weber Konstantinos Votanopoulos Clifford S Cho Jin He Shishir K Maithel Salvatore Pucciarelli Timothy M Pawlik Source Type: research

Hyperthermic Intrathoracic Chemotherapy (HITHOC) for Pleural Disseminated Thymoma: A Systematic Literature Review
CONCLUSION: Combining cytoreductive surgery and HITHOC is feasible and safe for TPD. The strong heterogeneity in the literature impedes proper outcome analysis. More research is needed to better understand the additional benefit of HITHOC in the TPD setting.PMID:36151429 | DOI:10.1245/s10434-022-12461-9 (Source: Ann Oncol)
Source: Ann Oncol - September 23, 2022 Category: Cancer & Oncology Authors: Tom Vandaele Jan Van Slambrouck Viktor Proesmans Paul Clement Maarten Lambrecht Philippe Nafteux Dirk Van Raemdonck Laurens J Ceulemans Source Type: research