Radiation Fractionation Schedules Published During the COVID-19 Pandemic: A Systematic Review of the Quality of Evidence and Recommendations for Future Development.
tes C Abstract PURPOSE: Numerous publications during the COVID-19 pandemic recommended the use of hypofractionated radiation therapy. This project assessed aggregate changes in the quality of the evidence supporting these schedules to establish a comprehensive evidence base for future reference and highlight aspects for future study. METHODS AND MATERIALS: Based on a systematic review of published recommendations related to dose fractionation during the COVID-19 pandemic, 20 expert panelists assigned to 14 disease groups named and graded the highest quality of evidence schedule(s) used routinely for each cond...
Source: Ann Oncol - September 22, 2020 Category: Cancer & Oncology Authors: Thomson DJ, Yom SS, Saeed H, El Naqa I, Ballas L, Bentzen SM, Chao ST, Choudhury A, Coles CE, Dover L, Guadagnolo BA, Guckenberger M, Hoskin P, Jabbour SK, Katz MS, Mukherjee S, Rembielak A, Sebag-Montefiore D, Sher DJ, Terezakis SA, Thomas TV, Vogel J, E Tags: Int J Radiat Oncol Biol Phys Source Type: research

Cancer Treatment Decision-Making During the COVID-19 Pandemic: Data Over Opinion.
PMID: 32890502 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - September 7, 2020 Category: Cancer & Oncology Authors: Spratt DE Tags: Int J Radiat Oncol Biol Phys Source Type: research

ASO Author Reflections: It is Time to Prioritize Exercise in Pancreatic Cancer Survivorship.
PMID: 32886285 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - September 4, 2020 Category: Cancer & Oncology Authors: Parker NH, Katz MHG Tags: Ann Surg Oncol Source Type: research

The Landmark Series: Mastectomy Trials (Skin-Sparing and Nipple-Sparing and Reconstruction Landmark Trials).
Abstract Despite advances in medical therapy, the foundation of breast cancer treatment is surgery. The landscape of operative intervention for breast cancer has shifted toward less invasive techniques, resulting in improved cosmesis and lower morbidity while maintaining oncologic integrity. In this article, we review the body of literature contributing to landmark advances in mastectomy for the treatment of breast cancer. PMID: 32886286 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - September 4, 2020 Category: Cancer & Oncology Authors: Elmore LC, Dietz JR, Myckatyn TM, Margenthaler JA Tags: Ann Surg Oncol Source Type: research

ASO Author Reflections: Immediate Lymphatic Reconstruction: A Proactive Approach to Breast Cancer-Related Lymphedema.
PMID: 32886287 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - September 4, 2020 Category: Cancer & Oncology Authors: Cook JA, Hassanein AH Tags: Ann Surg Oncol Source Type: research

Factors Influencing Exercise Following Pancreatic Tumor Resection.
In this study, we quantified exercise among survivors following pancreatic tumor resection and characterized concordance with established guidelines. METHODS: We quantified exercise frequency, duration, and intensity among survivors who underwent pancreatectomy for adenocarcinoma or a neuroendocrine tumor at our center from 2000 to 2017 and compared them with American College of Sports Medicine Guidelines for Cancer Survivors. Additional surveys measured motivation to exercise, barrier self-efficacy, quality of life, and fatigue. Multivariable models were constructed to evaluate associations between clinicodemogr...
Source: Ann Oncol - September 4, 2020 Category: Cancer & Oncology Authors: Parker NH, Basen-Engquist K, Rubin ML, Li Y, Prakash L, Ngo-Huang A, Gorzelitz J, Ikoma N, Lee JE, Katz MHG Tags: Ann Surg Oncol Source Type: research

Where the Other Half Dies: Analysis of Mortalities Occurring More Than 30 Days After Complex Cancer Surgery.
Abstract BACKGROUND: Nearly half of operative mortalities occur outside the traditionally studied 30-day period after surgery. To identify additional opportunities to improve surgical safety, the circumstances of deaths occurring 31-90 days after complex cancer surgery are analyzed. PATIENTS AND METHODS: Patients aged ≥ 65 years who died within 90 days of complex cancer surgery for nonmetastatic cancer were analyzed in the Surveillance, Epidemiology, and End Results (SEER)-Medicare and the Connecticut Tumor Registry (CTR) databases. RESULTS: Of the 36,114 patients undergoi...
Source: Ann Oncol - September 3, 2020 Category: Cancer & Oncology Authors: Resio BJ, Gonsalves L, Canavan M, Mueller L, Phillips C, Sathe T, Swett K, Boffa DJ Tags: Ann Surg Oncol Source Type: research

Distribution of Lymph Node Metastasis in Esophageal Squamous Cell Carcinoma After Trimodal Therapy.
CONCLUSIONS: About 50% of patients who were clinically diagnosed with LN metastasis before treatment were downstaged by NCRT, and their prognoses were relatively good. However, LN metastases were extensive at the cervical, mediastinal, and abdominal areas, even within the radiation field. Thus, systematic and adequate lymphadenectomy is required for ESCC treated by NCRT. PMID: 32885399 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - September 3, 2020 Category: Cancer & Oncology Authors: Hamai Y, Emi M, Ibuki Y, Kurokawa T, Yoshikawa T, Ohsawa M, Hirohata R, Murakami Y, Nishibuchi I, Imano N, Nagata Y, Okada M Tags: Ann Surg Oncol Source Type: research

ASO Author Reflections: Validated Prediction Model of Early Recurrence after Resection for Gallbladder Cancer: Identifying a Subset of Patients Who May be Better Served with Neoadjuvant Therapy.
PMID: 32880034 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - September 2, 2020 Category: Cancer & Oncology Authors: Sahara K, Tsilimigras DI, Pawlik TM Tags: Ann Surg Oncol Source Type: research

The Negative Impact of Preoperative Chemotherapy on Survival After Esophagectomy for Vulnerable Elderly Patients with Esophageal Cancer.
This study retrospectively reviewed the data for 42 patients ages 75-80 years with cStage 2 or 3 esophageal cancer who underwent esophagectomy between October 2002 and February 2019. The patients who received preoperative chemotherapy were compared with those who did not. The study also examined short- and long-term outcomes and the impact of preoperative chemotherapy on overall survival (OS) stratified by performance status (PS). RESULTS: Of the 42 patients, 18 underwent esophagectomy without preoperative chemotherapy and 24 underwent esophagectomy after preoperative chemotherapy. A significantly greater proport...
Source: Ann Oncol - September 2, 2020 Category: Cancer & Oncology Authors: Booka E, Haneda R, Ishii K, Tsushima T, Yasui H, Tsubosa Y Tags: Ann Surg Oncol Source Type: research

Association of CEP72 rs924607 TT Genotype with Vincristine-induced Peripheral Neuropathy Measured by Motor Nerve Conduction Studies.
Abstract Vincristine is at the core of many treatment protocols for childhood malignancies. The major dose-limiting side effect is vincristine-induced peripheral neuropathy (VIPN) which may cause morbidity and disrupt curative treatment. Several studies have tried to identify pharmacogenetic biomarkers for susceptibility to vincristine-induced toxicity (Egbelakin A et al., Pediatr Blood Cancer 2011; 56: 361-367. Aplenc R et al., Br J Haematol 2003; 122: 240-244. Diouf B et al., JAMA 2015; 313: 815-823. Zgheib NK et al., Pharmacogenet Genomics, 2018; 28: 189-195. Gutierrez-Camino A et al., Pharmacogenet Genomics 20...
Source: Ann Oncol - September 2, 2020 Category: Cancer & Oncology Authors: Kavčič M, Zečkanović A, Jazbec J, Debeljak M Tags: Klin Padiatr Source Type: research

Budget Impact Analysis of Preoperative Radioactive Seed Localization.
CONCLUSIONS: Our budget impact analysis shows that RSL using preloaded radioactive seeds was more expensive than WGL when considering per-lesion localization costs and specific costs related to radiation safety. Manually loading radioactive seed could be a cost-saving alternative to purchasing preloaded seeds. Our breakdown of costs can provide a framework for other centres to determine which localization method best suit their departments. PMID: 32875462 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - September 1, 2020 Category: Cancer & Oncology Authors: Law W, Look Hong N, Ravi A, Day L, Somani Y, Wright FC, Nofech-Mozes S, Tran WT, Curpen B Tags: Ann Surg Oncol Source Type: research

Compliance with Specific Recommendations and Tasks Reduces Nipple Necrosis Rates in Prepectoral Implant-Based Reconstruction After Nipple-Sparing Mastectomy.
PMID: 32875463 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - September 1, 2020 Category: Cancer & Oncology Authors: Franceschini G, Masetti R Tags: Ann Surg Oncol Source Type: research

Taiwan Society of Colon and Rectal Surgeons (TSCRS) Consensus for Cytoreduction Selection in Metastatic Colorectal Cancer.
CONCLUSIONS: mCRC patients undergoing R0 resection have the greatest survival advantage following surgery. Our role as a multidisciplinary team (MDT) should be to treat potentially resectable mCRC patients as rapidly and safely as possible, and achieve R0 resection as far as possible and for as long as possible (continuum of care). This TSCRS consensus statement aims to help build clinical capacity within the MDTs, while making better use of existing healthcare resources. PMID: 32875464 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - September 1, 2020 Category: Cancer & Oncology Authors: Lin CC, Chen TH, Wu YC, Fang CY, Wang JY, Chen CP, Huang KW, Jiang JK Tags: Ann Surg Oncol Source Type: research

Development of a Classification Tree to Predict Implant-Based Reconstruction Failure with or without Postmastectomy Radiation Therapy for Breast Cancer.
Abstract PURPOSE: The aim of this study was to determine the complications, incidence, and predictors of implant-based reconstruction failure (RF) among patients treated with mastectomy for breast cancer. METHODS: We retrospectively reviewed 108 patients who underwent mastectomy, tissue expander, and implant-based breast reconstruction with or without radiation therapy (RT) at our institution (2000-2014). Descriptive statistics determined complication incidences, with major complications defined as any complications requiring surgical intervention or inpatient management. Chi square and Fisher's exact tests d...
Source: Ann Oncol - September 1, 2020 Category: Cancer & Oncology Authors: Chen JJ, von Eyben R, Gutkin PM, Hawley E, Dirbas FM, Lee GK, Horst KC Tags: Ann Surg Oncol Source Type: research

ASO Author Reflections: Sequential Decision Tree Analysis Reveals Pivotal Branch Points in Predicting Implant-Based Reconstruction Failure Outcomes.
PMID: 32875466 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - September 1, 2020 Category: Cancer & Oncology Authors: Chen JJ, Horst KC Tags: Ann Surg Oncol Source Type: research

Peritoneal Lavage Tumor DNA as a Novel Biomarker for Predicting Peritoneal Recurrence in Pancreatic Ductal Adenocarcinoma.
CONCLUSIONS: As a promising biomarker, ptDNA may predict poor prognosis and peritoneal recurrence in PDAC, resolving the controversy surrounding CY. PMID: 32875467 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - September 1, 2020 Category: Cancer & Oncology Authors: Suenaga M, Fujii T, Yamada S, Hayashi M, Shinjo K, Takami H, Niwa Y, Sonohara F, Shimizu D, Kanda M, Kobayashi D, Tanaka C, Nakayama G, Koike M, Fujiwara M, Kondo Y, Kodera Y Tags: Ann Surg Oncol Source Type: research

Longitudinal study of cognitive function in glioma patients treated with modern radiotherapy techniques and standard chemotherapy.
Conclusion: The present study suggests that the currently used arc-based radiotherapy and chemotherapy might affect cognitive function less negatively than previously described during treatment and in the first year after treatment in malignant glioma patients. In general, a high cognitive test score at baseline was associated with longer time to progression and with longer survival. PMID: 32847475 [PubMed - in process] (Source: Ann Oncol)
Source: Ann Oncol - August 29, 2020 Category: Cancer & Oncology Authors: Rydelius A, Lätt J, Kinhult S, Engelholm S, Van Westen D, Pihlsgård M, Bengzon J, Sundgren PC, Lilja Å Tags: Acta Oncol Source Type: research

Gemcitabine-Based Neoadjuvant Treatment in Borderline Resectable Pancreatic Ductal Adenocarcinoma: A Meta-Analysis of Individual Patient Data.
Abstract Background: Non-randomized studies have investigated multi-agent gemcitabine-based neo-adjuvant therapies (GEM-NAT) in borderline resectable pancreatic ductal adenocarcinoma (BR-PDAC). Treatment sequencing and specific elements of neoadjuvant treatment are still under investigation. The present meta-analysis aims to assess the effectiveness of GEM-NAT on overall survival (OS) in BR-PDAC. Patients and Methods: A meta-analysis of individual participant data (IPD) on GEM-NAT for BR-PDAC were performed. The primary outcome was OS after treatment with GEM-based chemotherapy. In the Individual Patient Data anal...
Source: Ann Oncol - August 29, 2020 Category: Cancer & Oncology Authors: Giovinazzo F, Soggiu F, Jang JY, Versteijne E, van Tienhoven G, van Eijck CH, Han Y, Choi SH, Kang CM, Zalupski M, Ahmad H, Yentz S, Helton S, Rose JB, Takishita C, Nagakawa Y, Abu Hilal M Tags: Front Oncol Source Type: research

Tailoring Intensity of Active Surveillance for Low-Risk Prostate Cancer Based on Individualized Prediction of Risk Stability.
Abstract Importance: Active surveillance is increasingly recognized as the preferred standard of care for men with low-risk prostate cancer. However, active surveillance requires repeated assessments, including prostate-specific antigen tests and biopsies that may increase anxiety, risk of complications, and cost. Objective: To identify and validate clinical parameters that can identify men who can safely defer follow-up prostate cancer assessments. Design, Setting, and Participants: The Canary Prostate Active Surveillance Study (PASS) is a multicenter, prospective active surveillance cohort study initia...
Source: Ann Oncol - August 27, 2020 Category: Cancer & Oncology Authors: Cooperberg MR, Zheng Y, Faino AV, Newcomb LF, Zhu K, Cowan JE, Brooks JD, Dash A, Gleave ME, Martin F, Morgan TM, Nelson PS, Thompson IM, Wagner AA, Carroll PR, Lin DW Tags: JAMA Oncol Source Type: research

Ann Oncol; +20 new citations
20 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Ann Oncol These pubmed results were generated on 2020/08/26PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: Ann Oncol)
Source: Ann Oncol - August 26, 2020 Category: Cancer & Oncology Tags: Report Source Type: research

Ann Oncol; +23 new citations
23 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Ann Oncol These pubmed results were generated on 2020/08/20PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: Ann Oncol)
Source: Ann Oncol - August 20, 2020 Category: Cancer & Oncology Tags: Report Source Type: research

Ann Oncol; +16 new citations
16 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Ann Oncol These pubmed results were generated on 2020/08/19PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: Ann Oncol)
Source: Ann Oncol - August 19, 2020 Category: Cancer & Oncology Tags: Report Source Type: research

Vesicovaginal Fistula Repair by Modified Martius Flap: A Step-by-Step Surgical Technique Video.
CONCLUSIONS: Martius flap is a repair technique used for complex fistula in the perineal region. It is a simple, safe, and reproducible procedure with good long-term functional and esthetic results. PMID: 32797377 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - August 14, 2020 Category: Cancer & Oncology Authors: Marina T, Lago V, Padilla P, Matute L, Domingo S Tags: Ann Surg Oncol Source Type: research

ASO Author Reflections: Nodal Downstaging and Conversion to Breast-Conserving Surgery Following Neoadjuvant Endocrine Therapy.
PMID: 32797378 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - August 14, 2020 Category: Cancer & Oncology Authors: Montagna G, Morrow M, Pilewskie M Tags: Ann Surg Oncol Source Type: research

Ann Oncol; +86 new citations
86 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Ann Oncol These pubmed results were generated on 2020/08/13PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: Ann Oncol)
Source: Ann Oncol - August 13, 2020 Category: Cancer & Oncology Tags: Report Source Type: research

Ann Oncol; +22 new citations
22 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Ann Oncol These pubmed results were generated on 2020/08/05PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: Ann Oncol)
Source: Ann Oncol - August 5, 2020 Category: Cancer & Oncology Tags: Report Source Type: research

Ann Oncol; +19 new citations
19 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Ann Oncol These pubmed results were generated on 2020/08/03PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: Ann Oncol)
Source: Ann Oncol - August 3, 2020 Category: Cancer & Oncology Tags: Report Source Type: research

Ann Oncol; +22 new citations
22 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Ann Oncol These pubmed results were generated on 2020/08/02PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: Ann Oncol)
Source: Ann Oncol - August 2, 2020 Category: Cancer & Oncology Tags: Report Source Type: research

Ann Oncol; +27 new citations
27 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Ann Oncol These pubmed results were generated on 2020/07/30PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: Ann Oncol)
Source: Ann Oncol - July 30, 2020 Category: Cancer & Oncology Tags: Report Source Type: research

Ann Oncol; +45 new citations
45 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Ann Oncol These pubmed results were generated on 2020/07/28PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: Ann Oncol)
Source: Ann Oncol - July 29, 2020 Category: Cancer & Oncology Tags: Report Source Type: research

Ann Oncol; +25 new citations
25 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Ann Oncol These pubmed results were generated on 2020/07/24PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: Ann Oncol)
Source: Ann Oncol - July 24, 2020 Category: Cancer & Oncology Tags: Report Source Type: research

A Potential Indication for Adjuvant Therapy in Node-Negative Esophageal Squamous Cell Carcinoma.
PMID: 32691336 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - July 20, 2020 Category: Cancer & Oncology Authors: Popoff AM Tags: Ann Surg Oncol Source Type: research

Management of Appendiceal Neuroendocrine Tumors: Metastatic Potential of Small Tumors.
Abstract BACKGROUND: Appendiceal neuroendocrine tumors (ANETs) are rare neoplasms usually discovered incidentally during appendectomy. ANETs 
Source: Ann Oncol - July 20, 2020 Category: Cancer & Oncology Authors: Landry JP, Voros BA, Ramirez RA, Boudreaux JP, Woltering EA, Thiagarajan R Tags: Ann Surg Oncol Source Type: research

Relationship between Cancer Diagnosis and Complications Following Pancreatoduodenectomy for Duodenal Adenoma.
We examined factors associated with final malignant pathology and evaluated the postoperative course of patients with DA versus pancreatic ductal adenocarcinoma (PDAC). METHODS: We retrospectively analyzed patients with DA who underwent PD from 2008 to 2018 and assessed the accuracy rate of preoperative biopsy and factors associated with final malignant pathology. Complications for DA patients were compared with those of matched PDAC patients. RESULTS: Forty-five consecutive patients who underwent PD for DA were identified, and the preoperative biopsy false negative rate was 29. Factors associated with final mali...
Source: Ann Oncol - July 20, 2020 Category: Cancer & Oncology Authors: Eng NL, Mustin DE, Lovasik BP, Turgeon MK, Gamboa AC, Shah MM, Cardona K, Sarmiento JM, Russell MC, Maithel SK, Switchenko JM, Kooby DA Tags: Ann Surg Oncol Source Type: research

ASO Author Reflections: Conversion During Attempted Minimally Invasive Adrenalectomy for Adrenocortical Carcinoma: A Cautionary Tale.
PMID: 32691339 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - July 20, 2020 Category: Cancer & Oncology Authors: DeLozier OM, Dickson PV Tags: Ann Surg Oncol Source Type: research

ASO Author Reflections: Individualized Mediastinal Lymph Node Dissection for Lung Cancer: Do Not Neglect Station 3A Lymph Node.
PMID: 32691340 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - July 20, 2020 Category: Cancer & Oncology Authors: Liu C, Wei S, Liu L Tags: Ann Surg Oncol Source Type: research

ASO Author Reflections: Percutaneous Hepatic Perfusion with Melphalan in Patients with Unresectable Hepatic Metastases from Ocular Melanoma.
PMID: 32683632 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - July 18, 2020 Category: Cancer & Oncology Authors: Meijer TS, Burgmans MC Tags: Ann Surg Oncol Source Type: research

Baseline Screening MRI Uptake and Findings in Women with ≥ 20% Lifetime Risk of Breast Cancer.
CONCLUSIONS: In the setting of an HRBC, 70% of women with a ≥ 20% lifetime risk of breast cancer pursued screening MRI when recommended. On baseline screen, the rate of MRI-detected breast cancer was low (1%); however, malignancies were mammographically occult and identified at an early stage. Despite a low cancer rate, nearly one in four women required additional diagnostic investigation. Prescreening counselling should include a discussion of this possibility, and longer-term follow-up of screening MRI is needed in this high-risk population. PMID: 32683633 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - July 18, 2020 Category: Cancer & Oncology Authors: Laws A, Mulvey TM, Jalbert N, Dalton S, Kantor O, Harris KA, Krag KJ, Walsh EP, Coopey SB Tags: Ann Surg Oncol Source Type: research

ASO Author Reflections: Centralization of High-Risk Cancer Surgery and Implications for Vulnerable Communities.
PMID: 32683634 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - July 18, 2020 Category: Cancer & Oncology Authors: Diaz A, Pawlik TM Tags: Ann Surg Oncol Source Type: research

Association of RAS Mutation Location and Oncologic Outcomes After Resection of Colorectal Liver Metastases.
Abstract BACKGROUND: RAS mutations are prognostic for patients with metastatic colorectal cancer (mCRC). We investigated clinical, pathologic, and survival differences based on RAS exon for patients with colorectal liver metastases (CRLM). METHODS: This retrospective, single-center study included patients with R0/R1 resection of CRLM from 1992 to 2016. Patients with unresected extrahepatic disease or liver-first resection were excluded. Overall survival (OS) and recurrence-free survival were assessed and stratified by mutation status and location. Fisher's exact test, Wilcoxon rank-sum test, and log-rank test...
Source: Ann Oncol - July 18, 2020 Category: Cancer & Oncology Authors: Saadat LV, Boerner T, Goldman DA, Gonen M, Frankel TL, Vakiani E, Kingham TP, Jarnagin WR, Wei AC, Soares KC, Solit DB, D'Angelica MI Tags: Ann Surg Oncol Source Type: research

CDK12-Mutated Prostate Cancer: Clinical Outcomes With Standard Therapies and Immune Checkpoint Blockade.
CONCLUSION: CDK12 mutations define an aggressive prostate cancer subgroup, with a high rate of metastases and short overall survival. CPI may be effective in a minority of these patients, and exploratory analysis supports using anti-programmed cell death protein 1 drugs early. Prospective studies testing CPI in this subset of patients with prostate cancer are warranted. PMID: 32671317 [PubMed] (Source: Ann Oncol)
Source: Ann Oncol - July 17, 2020 Category: Cancer & Oncology Authors: Schweizer MT, Ha G, Gulati R, Brown LC, McKay RR, Dorff T, Hoge ACH, Reichel J, Vats P, Kilari D, Patel V, Oh WK, Chinnaiyan A, Pritchard CC, Armstrong AJ, Montgomery RB, Alva A Tags: JCO Precis Oncol Source Type: research

Ann Oncol; +16 new citations
16 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Ann Oncol These pubmed results were generated on 2020/07/16PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: Ann Oncol)
Source: Ann Oncol - July 16, 2020 Category: Cancer & Oncology Tags: Report Source Type: research

Positron Emission Tomography-Directed Therapy for Patients With Limited-Stage Diffuse Large B-Cell Lymphoma: Results of Intergroup National Clinical Trials Network Study S1001.
Abstract PURPOSE: Diffuse large B-cell lymphoma (DLBCL) presents as a limited-stage disease in 25% to 30% of patients, with better overall survival (OS) than that for advanced-stage disease but with continuous relapse regardless of treatment approach. The preferred treatment is abbreviated rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) and radiation therapy. On the basis of promising results of positron emission tomography (PET)-directed treatment approaches, we designed a National Clinical Trials Network (NCTN) study to improve outcomes and decrease toxicity. METHODS: Patients with nonbulky (
Source: Ann Oncol - July 13, 2020 Category: Cancer & Oncology Authors: Persky DO, Li H, Stephens DM, Park SI, Bartlett NL, Swinnen LJ, Barr PM, Winegarden JD, Constine LS, Fitzgerald TJ, Leonard JP, Kahl BS, LeBlanc ML, Song JY, Fisher RI, Rimsza LM, Smith SM, Miller TP, Friedberg JW Tags: J Clin Oncol Source Type: research

It Is Time to Rethink Biomarkers for Surveillance of Small Bowel Neuroendocrine Tumors.
This study sought to determine the performance of chromogranin A (CgA), pancreastatin (PST), neurokinin A (NKA), and serotonin (5HT) during follow-up assessment of resected SBNETs. METHODS: An institutional database identified patients undergoing surgery for SBNETs. Tumor biomarker levels were assessed as categorical (normal vs elevated) and continuous variables for association with progression-free survival (PFS) and overall survival (OS) via the Kaplan-Meier method with Cox multivariable models adjusted for confounders. Sensitivity, specificity, and predictive values...
Source: Ann Oncol - July 11, 2020 Category: Cancer & Oncology Authors: Tran CG, Sherman SK, Scott AT, Ear PH, Chandrasekharan C, Bellizzi AM, Dillon JS, O'Dorisio TM, Howe JR Tags: Ann Surg Oncol Source Type: research

Implications of Conversion during Attempted Minimally Invasive Adrenalectomy for Adrenocortical Carcinoma.
CONCLUSIONS: ACC is a rare tumor for which adequate oncologic resection is the only chance for cure. Given the relatively high rate of conversion and its associated inferior survival, open resection should be considered standard of care for known or suspected ACC. PMID: 32656720 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - July 11, 2020 Category: Cancer & Oncology Authors: Delozier OM, Stiles ZE, Deschner BW, Drake JA, Deneve JL, Glazer ES, Tsao MW, Yakoub D, Dickson PV Tags: Ann Surg Oncol Source Type: research

Robotic Gastrectomy for Gastric Adenocarcinoma in the USA: Insights and Oncologic Outcomes in 220 Patients.
CONCLUSIONS: These findings support the safety and oncologic feasibility of robotic gastrectomy for selected patients with gastric cancer. Proficiency can be achieved by 20 cases and mastery by 60-80 cases. Ideal candidates for this approach are patients with few comorbidities, BMI 
Source: Ann Oncol - July 11, 2020 Category: Cancer & Oncology Authors: Strong VE, Russo AE, Nakauchi M, Schattner M, Selby LV, Herrera G, Tang L, Gonen M Tags: Ann Surg Oncol Source Type: research

ASO Author Reflections: Laparoscopic Pancreatic Head Preserving Total Duodenectomy-You Can Eat Your Cake and Have it Too.
PMID: 32651699 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - July 11, 2020 Category: Cancer & Oncology Authors: Vega EA, Asbun HJ, Conrad C Tags: Ann Surg Oncol Source Type: research

Ann Oncol; +30 new citations
30 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Ann Oncol These pubmed results were generated on 2020/07/10PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: Ann Oncol)
Source: Ann Oncol - July 10, 2020 Category: Cancer & Oncology Tags: Report Source Type: research

Ann Oncol; +20 new citations
20 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Ann Oncol These pubmed results were generated on 2020/07/07PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: Ann Oncol)
Source: Ann Oncol - July 7, 2020 Category: Cancer & Oncology Tags: Report Source Type: research