Comment on "Surgical Outcomes and Comparative Analysis of Transduodenal Ampullectomy and Pancreaticoduodenectomy: A Single-Center Study"
Ann Surg Oncol. 2022 Jan 23. doi: 10.1245/s10434-022-11332-7. Online ahead of print.NO ABSTRACTPMID:35067788 | DOI:10.1245/s10434-022-11332-7 (Source: Ann Oncol)
Source: Ann Oncol - January 24, 2022 Category: Cancer & Oncology Authors: Gaohui Yue Yunqiang Cai Source Type: research

Disparities in Access to Oncologic Care in Pancreatic Cancer: A Systematic Review
CONCLUSION: Significant sociodemographic disparities in access to equitable oncologic care exist along the continuum of pancreatic cancer care. Multiple patient, provider, and systemic factors contribute to these disparities. The ongoing study of these disparities is important to elucidate processes that may be targeted to improve access to equitable oncologic care for patients with pancreatic cancer.PMID:35067789 | DOI:10.1245/s10434-021-11258-6 (Source: Ann Oncol)
Source: Ann Oncol - January 24, 2022 Category: Cancer & Oncology Authors: Annabelle L Fonseca Hamza Khan Krista R Mehari Deepa Cherla Martin J Heslin Fabian M Johnston Source Type: research

Weight Tracking as a Novel Prognostic Marker After Pancreatectomy
Ann Surg Oncol. 2022 Jan 23. doi: 10.1245/s10434-022-11325-6. Online ahead of print.ABSTRACTBACKGROUND: Objective measures of post-pancreatectomy weight change for pancreatic ductal adenocarcinoma (PDAC) have not been extensively studied for long-term outcomes. We used weight measurements in our institutional medical record to analyze trends in post-pancreatectomy weight and determine the association with disease status.METHODS: Pancreatectomies for PDAC (n = 315) and benign indications (n = 111) were identified. Preoperative baseline, minimum postoperative (Min #1), and subsequent postoperative maximum (Max) weights were ...
Source: Ann Oncol - January 24, 2022 Category: Cancer & Oncology Authors: Jonathan J Hue Lee M Ocuin Ravi K Kyasaram John Shanahan Goutham Rao Luke D Rothermel John B Ammori Jeffrey M Hardacre Jordan M Winter Sarah C Markt Source Type: research

Evaluation of Survival and Postoperative Radiation Among Patients with Advanced Medullary Thyroid Carcinoma: An Analysis of the National Cancer Database
This study compared survival between patients who had medullary thyroid cancer (MTC) treated with surgery alone and patients who underwent surgery and radiation (SRT).METHODS: Patients from the National Cancer Database (NCDB) with a diagnosis of stage 3 or 4 MTC, lymph node disease, and no distant metastases between 2008 and 2016 were studied. Kaplan-Meier analyses and log-rank statistics were used to estimate and compare overall survival between patients treated with surgery alone and those treated with SRT. Mutlivariable Cox proportional hazards models and propensity-matching were used to adjust for confounding and selec...
Source: Ann Oncol - January 24, 2022 Category: Cancer & Oncology Authors: Thomas J Ow Vikas Mehta Seokhwa Kim Mayand Vakil Patricia Friedmann Haejin In Source Type: research

The Impact of Commission on Cancer Accreditation Status, Hospital Rurality and Hospital Size on Quality Measure Performance Rates
Ann Surg Oncol. 2022 Jan 23. doi: 10.1245/s10434-021-11304-3. Online ahead of print.ABSTRACTBACKGROUND: Rural cancer patients receive lower-quality care and experience worse outcomes than urban patients. Commission on Cancer (CoC) accreditation requires hospitals to monitor performance on evidence-based quality measuresPlease confirm the list of authors is correc, but the impact of accreditation is not clear due to lack of data from non-accredited facilities and confounding between patient rurality and hospital accreditation, rurality, and size.METHODS: This retrospective, observational study assessed associations between ...
Source: Ann Oncol - January 24, 2022 Category: Cancer & Oncology Authors: Mary C Schroeder Xiang Gao Ingrid Lizarraga Amanda R Kahl Mary E Charlton Source Type: research

Initial Experience Using Magseed for Breast Lesion Localization Compared With Wire-Guided Localization: Analysis of Volume and Margin Clearance Rates
CONCLUSIONS: Magnetic seeds were successfully used for lesion localization in this cohort. Pathologic examination of specimens suggested that the surgeons were able to remove closer to optimal volumes of tissue than those using wire-guided intervention. Removal of less tissue did not result in higher rates of margin positivity or a need for re-intervention to achieve negative margin status. Magnetic seeds are a feasible and non-inferior approach that overcomes many drawbacks of other localization methods.PMID:35067793 | DOI:10.1245/s10434-022-11327-4 (Source: Ann Oncol)
Source: Ann Oncol - January 24, 2022 Category: Cancer & Oncology Authors: Roberta E Redfern Robin B Shermis Source Type: research

A Safe and Practical Cycle for Team-Based Development and Implementation of In-House Clinical Software
CONCLUSIONS: The principles and methodology described here can be implemented in a range of practice settings regardless of whether or not dedicated resources are available for software development. In addition to teamwork with defined roles, documentation, and use of incident learning, we strongly recommend having a written policy on the process, using phased testing, and incorporating independent oversight and approval before use for patient care. This rigorous process ensures continuous monitoring for and mitigatation of any high risk hazards.PMID:35071827 | PMC:PMC8767245 | DOI:10.1016/j.adro.2021.100768 (Source: Ann Oncol)
Source: Ann Oncol - January 24, 2022 Category: Cancer & Oncology Authors: Jean M Moran Kelly C Paradis Scott W Hadley Martha M Matuszak Charles S Mayo Katherine Woch Naheedy Xiaoping Chen Dale W Litzenberg James Irrer Maria G Ditman Pam Burger Marc L Kessler Source Type: research

ASO Visual Abstract: Iterative Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy for Recurrent Mucinous  Adenocarcinoma of the Appendix
Ann Surg Oncol. 2022 Jan 24. doi: 10.1245/s10434-021-11257-7. Online ahead of print.NO ABSTRACTPMID:35072857 | DOI:10.1245/s10434-021-11257-7 (Source: Ann Oncol)
Source: Ann Oncol - January 24, 2022 Category: Cancer & Oncology Authors: Felipe Lopez-Ramirez Vadim Gushchin Michelle Sittig Mary Caitlin King Ekaterina Baron Andrei Nikiforchin Carol Nieroda Armando Sardi Source Type: research

ASO Visual Abstract: Upstaging of Fibroepithelial Lesions-A Single-Institution Experience
Ann Surg Oncol. 2022 Jan 24. doi: 10.1245/s10434-021-11040-8. Online ahead of print.NO ABSTRACTPMID:35072858 | DOI:10.1245/s10434-021-11040-8 (Source: Ann Oncol)
Source: Ann Oncol - January 24, 2022 Category: Cancer & Oncology Authors: Srivarshini Cherukupalli Mohan Joshua Tseng Ashley Marumoto Stephanie Angarita Farnaz Dadmanesh Farin Amersi Armando Giuliano Alice Chung Source Type: research

ASO Visual Abstract: Stromal Tumor-Associated Macrophage Infiltration Predicts Poor Clinical Outcomes in Muscle-Invasive Bladder Cancer Patients
Ann Surg Oncol. 2022 Jan 24. doi: 10.1245/s10434-021-11262-w. Online ahead of print.NO ABSTRACTPMID:35072859 | DOI:10.1245/s10434-021-11262-w (Source: Ann Oncol)
Source: Ann Oncol - January 24, 2022 Category: Cancer & Oncology Authors: Shengming Jin Han Zeng Zhaopei Liu Kaifeng Jin Chunnan Liu Sen Yan Yanze Yu Runze You Hongyi Zhang Yuan Chang Le Xu Jiejie Xu Zewei Wang Yu Zhu Source Type: research

The Association of Frailty with Outcomes after Cancer Surgery: A Systematic Review and Metaanalysis
CONCLUSIONS: In adults having elective cancer surgery, frailty is strongly associated with adverse health outcomes. Preoperative frailty assessment should be considered in prognostication.PMID:35072860 | DOI:10.1245/s10434-021-11321-2 (Source: Ann Oncol)
Source: Ann Oncol - January 24, 2022 Category: Cancer & Oncology Authors: Julia F Shaw Dan Budiansky Fayza Sharif Daniel I McIsaac Source Type: research

ASO Visual Abstract: Failure to Thrive Following Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy: Causes and Consequences
Ann Surg Oncol. 2022 Jan 24. doi: 10.1245/s10434-021-11184-7. Online ahead of print.NO ABSTRACTPMID:35072861 | DOI:10.1245/s10434-021-11184-7 (Source: Ann Oncol)
Source: Ann Oncol - January 24, 2022 Category: Cancer & Oncology Authors: Caroline J Rieser Jurgis Alvikas Heather Phelos Lauren B Hall Amer H Zureikat Andrew Lee Melanie Ongchin Matthew P Holtzman James F Pingpank David L Bartlett M Haroon A Choudry Source Type: research

ASO Visual Abstract: Disparities in Utilization and Outcomes of Minimally Invasive Techniques for Gastric Cancer Surgery in the United States
Ann Surg Oncol. 2022 Jan 24. doi: 10.1245/s10434-021-11284-4. Online ahead of print.NO ABSTRACTPMID:35072862 | DOI:10.1245/s10434-021-11284-4 (Source: Ann Oncol)
Source: Ann Oncol - January 24, 2022 Category: Cancer & Oncology Authors: Joon Y Park Arjun Verma Zachary K Tran Michael A Mederos Peyman Benharash Mark Girgis Source Type: research

Surgery for Intraductal Papillary Mucinous Neoplasms of the Pancreas: Preoperative Factors Tipping the Scale of Decision-Making
CONCLUSIONS: In presumed IPMNs, the disease-specific risk of major morbidity and pancreatic insufficiency can be determined in the preoperative setting and used to personalize the possible surgical indication. Age and overweight status in case of PD/TP and diabetes in case of DP tip the scale toward less aggressive clinical management in the absence of features suggestive for malignancy.PMID:35072863 | DOI:10.1245/s10434-022-11326-5 (Source: Ann Oncol)
Source: Ann Oncol - January 24, 2022 Category: Cancer & Oncology Authors: Giovanni Marchegiani Stefano Crippa Giampaolo Perri Paola M V Rancoita Andrea Caravati Giulio Belfiori Tommaso Dall'Olio Francesca Aleotti Stefano Partelli Claudio Bassi Massimo Falconi Roberto Salvia Source Type: research

Kidney Preservation and Wilms Tumor Development in Children with Diffuse Hyperplastic Perilobar Nephroblastomatosis: A Report from the Children's Oncology Group Study AREN0534
CONCLUSIONS: Chemotherapy for patients with DHPLN was effective in preserving kidney function. Five-year OS is excellent, however the ideal type and duration of chemotherapy to prevent WT development remains elusive.PMID:35072864 | DOI:10.1245/s10434-021-11266-6 (Source: Ann Oncol)
Source: Ann Oncol - January 24, 2022 Category: Cancer & Oncology Authors: Peter F Ehrlich Brett Tornwall Murali M Chintagumpala Yueh-Yun Chi Fredric A Hoffer Elizabeth J Perlman John A Kalapurakal Anne Warwick Robert C Shamberger Geetika Khanna Thomas E Hamilton Kenneth W Gow Arnold C Paulino Eric J Gratias Elizabeth A Mullen J Source Type: research

ASO Author Reflections: Cisplatin- and Adrenaline-Based Intraperitoneal Chemotherapy Protocol for Ovarian Peritoneal Carcinosis: New Perspectives?
Ann Surg Oncol. 2022 Jan 24. doi: 10.1245/s10434-021-11296-0. Online ahead of print.NO ABSTRACTPMID:35072865 | DOI:10.1245/s10434-021-11296-0 (Source: Ann Oncol)
Source: Ann Oncol - January 24, 2022 Category: Cancer & Oncology Authors: Brice Paquette Source Type: research

Correction to: Effect of Preoperative Treatment on the Performance of Predictive Nomograms in Primary Retroperitoneal Sarcoma
Ann Surg Oncol. 2022 Jan 24. doi: 10.1245/s10434-022-11361-2. Online ahead of print.NO ABSTRACTPMID:35072866 | DOI:10.1245/s10434-022-11361-2 (Source: Ann Oncol)
Source: Ann Oncol - January 24, 2022 Category: Cancer & Oncology Authors: Deanna Ng David P Cyr Sally M Burtenshaw Dario Callegaro Alessandro Gronchi David Shultz Savtaj Brar Peter Chung Rebecca A Gladdy Charles Catton Carol J Swallow Source Type: research

First Extensive Analysis of < sup > 18 < /sup > F-Labeled Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography in a Large Cohort of Patients With HIV-Associated Hodgkin Lymphoma: Baseline Total Metabolic Tumor Volume Affects Prognosis
CONCLUSION: In this large series of HIV-HL patients with a homogeneous management, high TMTV on PET1 examination was associated with a poor prognosis.PMID:35073166 | DOI:10.1200/JCO.21.01228 (Source: Ann Oncol)
Source: Ann Oncol - January 24, 2022 Category: Cancer & Oncology Authors: Nicolas Louarn Lionel Galicier R émi Bertinchamp David Lussato Fran çoise Montravers Éric Oksenhendler Pascal Merlet Laurence G érard Laetitia Vercellino Source Type: research

Single cell DNA-seq depicts clonal evolution of multiple driver alterations in osimertinib resistant patients
CONCLUSIONS: Distinct molecular driver alterations at osimertinib resistance co-exist with initial EGFR mutations in single cancer cells. The clonal evolution of cancer cell populations emphasized their heterogeneity leading to osimertinib relapse. Combining two targeted treatments is effective to achieve clinical benefit.PMID:35066105 | DOI:10.1016/j.annonc.2022.01.004 (Source: Ann Oncol)
Source: Ann Oncol - January 23, 2022 Category: Cancer & Oncology Authors: J Chen F Facchinetti F Braye A A Yurchenko L Bigot S Ponce D Planchard A Gazzah S Nikolaev S Michiels D Vasseur L Lacroix L Tselikas C Nobre K A Olaussen F Andre J Y Scoazec F Barlesi J C Soria Y Loriot B Besse L Friboulet Source Type: research

Pure Laparoscopic Right Upper Transversal Hepatectomy
CONCLUSIONS: Laparoscopic RUTH is technically feasible and safe in selected patients with IRHV and CVs.PMID:35066717 | DOI:10.1245/s10434-022-11331-8 (Source: Ann Oncol)
Source: Ann Oncol - January 23, 2022 Category: Cancer & Oncology Authors: Fei Liu YongGang Wei Bo Li Source Type: research

ASO Author Reflections: Minimally Invasive Secondary Cytoreductive Surgery for Ovarian Cancer Lymph Node Recurrence: Shaping Treatment with All Arrows in our Quiver
Ann Surg Oncol. 2022 Jan 22. doi: 10.1245/s10434-022-11329-2. Online ahead of print.NO ABSTRACTPMID:35066718 | DOI:10.1245/s10434-022-11329-2 (Source: Ann Oncol)
Source: Ann Oncol - January 23, 2022 Category: Cancer & Oncology Authors: Matteo Loverro Raffaella Ergasti Carmine Conte Vitalba Gallitelli Dania Nachira Giulia Scaglione Anna Fagotti Giovanni Scambia Valerio Gallotta Source Type: research

ASO Author Reflections: Actual Sarcopenia in Esophageal Cancer Patients
Ann Surg Oncol. 2022 Jan 22. doi: 10.1245/s10434-022-11339-0. Online ahead of print.NO ABSTRACTPMID:35066719 | DOI:10.1245/s10434-022-11339-0 (Source: Ann Oncol)
Source: Ann Oncol - January 23, 2022 Category: Cancer & Oncology Authors: Akihiro Watanabe Taro Oshikiri Source Type: research

Mastectomy or Margin Re-excision? A Nomogram for Close/Positive Margins After Lumpectomy for DCIS
CONCLUSION: Using clinical and pathologic variables from initial diagnosis and surgery for DCIS, this nomogram predicts persistent positive margins with margin re-excision, and may be a valuable tool in surgical decision-making.PMID:35066720 | DOI:10.1245/s10434-021-11293-3 (Source: Ann Oncol)
Source: Ann Oncol - January 23, 2022 Category: Cancer & Oncology Authors: Catarina Martins Maia Cleo Siderides Shabnam Jaffer Christina Weltz Sarah Cate Soojin Ahn Susan Boolbol Meng Ru Erin Moshier Elisa Port Hank Schmidt Source Type: research

Recurrence and Survival Rates for 1400 Early Breast Tumors Treated with Intraoperative Radiation Therapy (IORT)
CONCLUSIONS: The local, regional, and distant recurrence rates observed were comparable to those reported in the literature for IORT but higher than those reported for standard forms of WBRT, hypofractionated treatment, or APBI. IORT benefits include convenience, decreased exposure to medical environments, and low complication rates.PMID:35066721 | DOI:10.1245/s10434-021-11295-1 (Source: Ann Oncol)
Source: Ann Oncol - January 23, 2022 Category: Cancer & Oncology Authors: Melvin J Silverstein Melinda S Epstein Peter Chen Kevin Lin Sadia Khan Lincoln Snyder Colleen Coleman Lisa Guerra Farideh Dehkordi-Vakil Brian Kim Source Type: research

ASO Author Reflection: Delayed Gastric Emptying as a Sentinel Event of Severe Complications in Retroperitoneal Sarcoma Surgery
Ann Surg Oncol. 2022 Jan 22. doi: 10.1245/s10434-021-11320-3. Online ahead of print.NO ABSTRACTPMID:35066722 | DOI:10.1245/s10434-021-11320-3 (Source: Ann Oncol)
Source: Ann Oncol - January 23, 2022 Category: Cancer & Oncology Authors: Marco Baia Sandro Pasquali Marco Fiore Source Type: research

Correction to: Impact of Bile Duct Tumor Thrombus on the Long-Term Surgical Outcomes of Hepatocellular Carcinoma Patients: A Propensity Score Matching Analysis
Ann Surg Oncol. 2022 Jan 22. doi: 10.1245/s10434-022-11335-4. Online ahead of print.NO ABSTRACTPMID:35066723 | DOI:10.1245/s10434-022-11335-4 (Source: Ann Oncol)
Source: Ann Oncol - January 23, 2022 Category: Cancer & Oncology Authors: Jun-Yi Wu Ju-Xian Sun Jia-Yi Wu Xiao-Xiao Huang Yan-Nan Bai Yong-Gang Wei Zhi-Bo Zhang Jian-Yin Zhou Shu-Qun Cheng Mao-Lin Yan Source Type: research

Is There a Relationship Between TILs and Regression in Melanoma?
This report describes a large multicenter study assessing the association between TILs and regression.METHODS: The Sentinel Lymph Node Working Group database was queried from 1993 to 2018 for cases with TILs and regression data. Clinicopathologic factors were correlated with regression and TIL status, sentinel lymph node (SLN) status, and overall survival (OS).RESULTS: The study enrolled 2450 patients. In 1811 cases, TILs (73.9%) were present, with regression present in 328 of these 1811 (18.1%) cases and in 49 (7.7%) of 639 cases without TILs. The presence of TILs was significantly associated with regression (p
Source: Ann Oncol - January 22, 2022 Category: Cancer & Oncology Authors: Steven Morrison Gang Han Faith Elenwa John T Vetto Graham Fowler Stanley P Leong Mohammed Kashani-Sabet Barbara Pockaj Heidi E Kosiorek Jonathan S Zager Jane L Messina Nicola Mozzillo Schlomo Schneebaum Dale Han Sentinel Lymph Node Working Group Source Type: research

ASO Visual Abstract: Patterns of Occult Metastasis to Level Va and Vb in Clinically Lateral Node-Positive Papillary Thyroid Carcinoma
Ann Surg Oncol. 2022 Jan 21. doi: 10.1245/s10434-021-11181-w. Online ahead of print.NO ABSTRACTPMID:35064333 | DOI:10.1245/s10434-021-11181-w (Source: Ann Oncol)
Source: Ann Oncol - January 22, 2022 Category: Cancer & Oncology Authors: Kunho Song YanLi Jin Mingyu Kim Seongjun Moon Da Beom Heo Ho-Ryun Won Jae Won Chang Bon Seok Koo Source Type: research

Testicular seminoma and non-seminoma: ESMO-EURACAN Clinical Practice Guideline for diagnosis, treatment and follow-up
Ann Oncol. 2022 Jan 17:S0923-7534(22)00007-2. doi: 10.1016/j.annonc.2022.01.002. Online ahead of print.NO ABSTRACTPMID:35065204 | DOI:10.1016/j.annonc.2022.01.002 (Source: Ann Oncol)
Source: Ann Oncol - January 22, 2022 Category: Cancer & Oncology Authors: J Oldenburg D M Berney C Bokemeyer M A Climent G Daugaard J A Gietema U De Giorgi H S Haugnes R A Huddart R Le ão A Sohaib S Gillessen T Powles ESMO Guidelines Committee EURACAN Source Type: research

Is There a Relationship Between TILs and Regression in Melanoma?
This report describes a large multicenter study assessing the association between TILs and regression.METHODS: The Sentinel Lymph Node Working Group database was queried from 1993 to 2018 for cases with TILs and regression data. Clinicopathologic factors were correlated with regression and TIL status, sentinel lymph node (SLN) status, and overall survival (OS).RESULTS: The study enrolled 2450 patients. In 1811 cases, TILs (73.9%) were present, with regression present in 328 of these 1811 (18.1%) cases and in 49 (7.7%) of 639 cases without TILs. The presence of TILs was significantly associated with regression (p
Source: Ann Oncol - January 22, 2022 Category: Cancer & Oncology Authors: Steven Morrison Gang Han Faith Elenwa John T Vetto Graham Fowler Stanley P Leong Mohammed Kashani-Sabet Barbara Pockaj Heidi E Kosiorek Jonathan S Zager Jane L Messina Nicola Mozzillo Schlomo Schneebaum Dale Han Sentinel Lymph Node Working Group Source Type: research

ASO Visual Abstract: Patterns of Occult Metastasis to Level Va and Vb in Clinically Lateral Node-Positive Papillary Thyroid Carcinoma
Ann Surg Oncol. 2022 Jan 21. doi: 10.1245/s10434-021-11181-w. Online ahead of print.NO ABSTRACTPMID:35064333 | DOI:10.1245/s10434-021-11181-w (Source: Ann Oncol)
Source: Ann Oncol - January 22, 2022 Category: Cancer & Oncology Authors: Kunho Song YanLi Jin Mingyu Kim Seongjun Moon Da Beom Heo Ho-Ryun Won Jae Won Chang Bon Seok Koo Source Type: research

Testicular seminoma and non-seminoma: ESMO-EURACAN Clinical Practice Guideline for diagnosis, treatment and follow-up
Ann Oncol. 2022 Jan 17:S0923-7534(22)00007-2. doi: 10.1016/j.annonc.2022.01.002. Online ahead of print.NO ABSTRACTPMID:35065204 | DOI:10.1016/j.annonc.2022.01.002 (Source: Ann Oncol)
Source: Ann Oncol - January 22, 2022 Category: Cancer & Oncology Authors: J Oldenburg D M Berney C Bokemeyer M A Climent G Daugaard J A Gietema U De Giorgi H S Haugnes R A Huddart R Le ão A Sohaib S Gillessen T Powles ESMO Guidelines Committee EURACAN Source Type: research

Investigation of sex and gender differences in oncology gains momentum: ESMO announces the launch of a Gender Medicine Task  Force
Ann Oncol. 2021 Dec 22:S0923-7534(21)04826-2. doi: 10.1016/j.annonc.2021.11.011. Online ahead of print.NO ABSTRACTPMID:35058112 | DOI:10.1016/j.annonc.2021.11.011 (Source: Ann Oncol)
Source: Ann Oncol - January 21, 2022 Category: Cancer & Oncology Authors: B C Özdemir S Oertelt-Prigione A A Adjei S Borchmann J B Haanen A Letsch O Mir A Quaas R H A Verhoeven A D Wagner Source Type: research

Proximity of immune and tumor cells underlies response to BRAF/MEK-targeted therapies in metastatic melanoma patients
NPJ Precis Oncol. 2022 Jan 20;6(1):6. doi: 10.1038/s41698-021-00249-1.ABSTRACTAcquired resistance to BRAF/MEK-targeted therapy occurs in the majority of melanoma patients that harbor BRAF mutated tumors, leading to relapse or progression and the underlying mechanism is unclear in many cases. Using multiplex immunohistochemistry and spatial imaging analysis of paired tumor sections obtained from 11 melanoma patients prior to BRAF/MEK-targeted therapy and when the disease progressed on therapy, we observed a significant increase of tumor cellularity in the progressed tumors and the close association of SOX10+ melanoma cells ...
Source: Ann Oncol - January 21, 2022 Category: Cancer & Oncology Authors: Chi Yan Sheau-Chiann Chen Gregory D Ayers Caroline A Nebhan Joseph T Roland Vivian L Weiss Douglas B Johnson Ann Richmond Source Type: research

Standardized Procedure of Transperineal Minimally Invasive Abdominoperineal Resection for Low Rectal Cancer
Ann Surg Oncol. 2022 Jan 21. doi: 10.1245/s10434-021-11214-4. Online ahead of print.ABSTRACTAlthough transperineal minimally invasive abdominoperineal resection (tp-APR) based on the concept of transanal total mesorectal excision has recently been used for rectal cancer, the operative procedure has not been standardized to date due to its technical difficulty. The tp-APR procedure used by the authors for a male patient with low rectal cancer is presented in this video.PMID:35059883 | DOI:10.1245/s10434-021-11214-4 (Source: Ann Oncol)
Source: Ann Oncol - January 21, 2022 Category: Cancer & Oncology Authors: Takeru Matsuda Ryuichiro Sawada Hiroshi Hasegawa Kimihiro Yamashita Masako Utsumi Hitoshi Harada Naoki Urakawa Hironobu Goto Shingo Kanaji Taro Oshikiri Yoshihiro Kakeji Source Type: research

ASO Author Reflections: Is There a Relationship Between TIL and Regression in Melanoma?
Ann Surg Oncol. 2022 Jan 21. doi: 10.1245/s10434-021-11264-8. Online ahead of print.NO ABSTRACTPMID:35059884 | DOI:10.1245/s10434-021-11264-8 (Source: Ann Oncol)
Source: Ann Oncol - January 21, 2022 Category: Cancer & Oncology Authors: Steven Morrison Jonathan S Zager John Vetto Source Type: research

ASO Visual Abstract: Perineural Invasion is a Powerful Prognostic Factor for Upper Tract Urothelial Carcinoma After Radical Nephroureterectomy
Ann Surg Oncol. 2022 Jan 20. doi: 10.1245/s10434-021-11310-5. Online ahead of print.NO ABSTRACTPMID:35059885 | DOI:10.1245/s10434-021-11310-5 (Source: Ann Oncol)
Source: Ann Oncol - January 21, 2022 Category: Cancer & Oncology Authors: Te-Wei Lin Hsiang-Ying Lee Sheau-Fang Yang Ching-Chia Li Hung-Lung Ke Wei-Ming Li Chia-Yang Li Hung-Pin Tu Wen-Jeng Wu Hsin-Chih Yeh Source Type: research

ASO Visual Abstract: Oncological Surgery during the COVID-19 pandemic-Effectiveness of Preoperative Screening and Factors Associated with Postoperative SARS-CoV-2 Infection
Ann Surg Oncol. 2022 Jan 20. doi: 10.1245/s10434-021-11242-0. Online ahead of print.NO ABSTRACTPMID:35059886 | DOI:10.1245/s10434-021-11242-0 (Source: Ann Oncol)
Source: Ann Oncol - January 21, 2022 Category: Cancer & Oncology Authors: Andr é Lopes Caroline B P Pastore Paula Deckers Izabela K M W Halla Ana Luiza Rezende Dias Marcos Vinicius Maia da Mata Adriana do Nascimento Martins Micaela Mazutti Viu Rossana Veronica Mendoza Lopez Alayne Domingues Yamada Source Type: research

Incorporation of novel therapies for the management of sickle cell disease: A pharmacist's perspective
J Oncol Pharm Pract. 2022 Jan 21:10781552211072468. doi: 10.1177/10781552211072468. Online ahead of print.ABSTRACTPatients with sickle cell disease (SCD) experience significant disease-related morbidity including multiorgan damage, chronic anemia, and debilitating pain crises. While hydroxyurea has been the primary disease modifying modality in SCD, novel therapies with unique mechanism of action have recently been approved. This review article examines the evidence surrounding the available SCD therapies to guide pharmacists on potential treatment selection and management strategies for patients with SCD. A systematic sea...
Source: Ann Oncol - January 21, 2022 Category: Cancer & Oncology Authors: Jacqueline C Dela-Pena Madeleine A King Julia Brown Victoria R Nachar Source Type: research

Adjuvant Nivolumab or Ipilimumab + Nivolumab for Melanoma Determined by Pathological Response to a Single Dose of Neoadjuvant Nivolumab
Ann Surg Oncol. 2022 Jan 21. doi: 10.1245/s10434-021-11199-0. Online ahead of print.NO ABSTRACTPMID:35061122 | DOI:10.1245/s10434-021-11199-0 (Source: Ann Oncol)
Source: Ann Oncol - January 21, 2022 Category: Cancer & Oncology Authors: Tahsin M Khan Martha E Teke Giorgos C Karakousis John T Miura Robert M Brody Jonathan M Hernandez Tara C Mitchell Source Type: research

ASO Visual Abstract: Impact of the COVID-19 Pandemic on Breast Cancer Stage at Diagnosis, Presentation, and Patient Management
Ann Surg Oncol. 2022 Jan 21. doi: 10.1245/s10434-021-11178-5. Online ahead of print.NO ABSTRACTPMID:35061123 | DOI:10.1245/s10434-021-11178-5 (Source: Ann Oncol)
Source: Ann Oncol - January 21, 2022 Category: Cancer & Oncology Authors: Jennifer E Tonneson Tanya L Hoskin Courtney N Day Diane M Durgan Christina A Dilaveri Judy C Boughey Source Type: research

ASO Author Reflections: The Management of Appendiceal Primary Peritoneal Surface Malignancies
Ann Surg Oncol. 2022 Jan 21. doi: 10.1245/s10434-021-11200-w. Online ahead of print.NO ABSTRACTPMID:35061124 | DOI:10.1245/s10434-021-11200-w (Source: Ann Oncol)
Source: Ann Oncol - January 21, 2022 Category: Cancer & Oncology Authors: Ashley Russo Alexandra Gangi Source Type: research

Management of the Top 10 Most Common Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy
JCO Oncol Pract. 2022 Jan 21:OP2100776. doi: 10.1200/OP.21.00776. Online ahead of print.NO ABSTRACTPMID:35061502 | DOI:10.1200/OP.21.00776 (Source: Ann Oncol)
Source: Ann Oncol - January 21, 2022 Category: Cancer & Oncology Authors: Bryan J Schneider Christina Lacchetti Kathryn Bollin Source Type: research

Development and Validation of a Predictive Model of Severe Fatigue After Breast Cancer Diagnosis: Toward a Personalized Framework in Survivorship Care
CONCLUSION: We propose a predictive model to assess fatigue among breast cancer survivors, within a personalized survivorship care framework. This may help clinicians to provide early management interventions or to correct modifiable risk factors and offer more tailored monitoring and education to patients at risk of severe post-treatment fatigue.PMID:35061509 | DOI:10.1200/JCO.21.01252 (Source: Ann Oncol)
Source: Ann Oncol - January 21, 2022 Category: Cancer & Oncology Authors: Antonio Di Meglio Julie Havas Davide Soldato Daniele Presti Elise Martin Barbara Pistilli Gwenn Menvielle Agnes Dumas Cecile Charles Sibille Everhard Anne-Laure Martin Charles Coutant Carole Tarpin Laurence Vanlemmens Christelle Levy Olivier Rigal Suzette Source Type: research

Investigation of sex and gender differences in oncology gains momentum: ESMO announces the launch of a Gender Medicine Task  Force
Ann Oncol. 2021 Dec 22:S0923-7534(21)04826-2. doi: 10.1016/j.annonc.2021.11.011. Online ahead of print.NO ABSTRACTPMID:35058112 | DOI:10.1016/j.annonc.2021.11.011 (Source: Ann Oncol)
Source: Ann Oncol - January 21, 2022 Category: Cancer & Oncology Authors: B C Özdemir S Oertelt-Prigione A A Adjei S Borchmann J B Haanen A Letsch O Mir A Quaas R H A Verhoeven A D Wagner Source Type: research

Proximity of immune and tumor cells underlies response to BRAF/MEK-targeted therapies in metastatic melanoma patients
NPJ Precis Oncol. 2022 Jan 20;6(1):6. doi: 10.1038/s41698-021-00249-1.ABSTRACTAcquired resistance to BRAF/MEK-targeted therapy occurs in the majority of melanoma patients that harbor BRAF mutated tumors, leading to relapse or progression and the underlying mechanism is unclear in many cases. Using multiplex immunohistochemistry and spatial imaging analysis of paired tumor sections obtained from 11 melanoma patients prior to BRAF/MEK-targeted therapy and when the disease progressed on therapy, we observed a significant increase of tumor cellularity in the progressed tumors and the close association of SOX10+ melanoma cells ...
Source: Ann Oncol - January 21, 2022 Category: Cancer & Oncology Authors: Chi Yan Sheau-Chiann Chen Gregory D Ayers Caroline A Nebhan Joseph T Roland Vivian L Weiss Douglas B Johnson Ann Richmond Source Type: research

Standardized Procedure of Transperineal Minimally Invasive Abdominoperineal Resection for Low Rectal Cancer
Ann Surg Oncol. 2022 Jan 21. doi: 10.1245/s10434-021-11214-4. Online ahead of print.ABSTRACTAlthough transperineal minimally invasive abdominoperineal resection (tp-APR) based on the concept of transanal total mesorectal excision has recently been used for rectal cancer, the operative procedure has not been standardized to date due to its technical difficulty. The tp-APR procedure used by the authors for a male patient with low rectal cancer is presented in this video.PMID:35059883 | DOI:10.1245/s10434-021-11214-4 (Source: Ann Oncol)
Source: Ann Oncol - January 21, 2022 Category: Cancer & Oncology Authors: Takeru Matsuda Ryuichiro Sawada Hiroshi Hasegawa Kimihiro Yamashita Masako Utsumi Hitoshi Harada Naoki Urakawa Hironobu Goto Shingo Kanaji Taro Oshikiri Yoshihiro Kakeji Source Type: research

ASO Author Reflections: Is There a Relationship Between TIL and Regression in Melanoma?
Ann Surg Oncol. 2022 Jan 21. doi: 10.1245/s10434-021-11264-8. Online ahead of print.NO ABSTRACTPMID:35059884 | DOI:10.1245/s10434-021-11264-8 (Source: Ann Oncol)
Source: Ann Oncol - January 21, 2022 Category: Cancer & Oncology Authors: Steven Morrison Jonathan S Zager John Vetto Source Type: research

ASO Visual Abstract: Perineural Invasion is a Powerful Prognostic Factor for Upper Tract Urothelial Carcinoma After Radical Nephroureterectomy
Ann Surg Oncol. 2022 Jan 20. doi: 10.1245/s10434-021-11310-5. Online ahead of print.NO ABSTRACTPMID:35059885 | DOI:10.1245/s10434-021-11310-5 (Source: Ann Oncol)
Source: Ann Oncol - January 21, 2022 Category: Cancer & Oncology Authors: Te-Wei Lin Hsiang-Ying Lee Sheau-Fang Yang Ching-Chia Li Hung-Lung Ke Wei-Ming Li Chia-Yang Li Hung-Pin Tu Wen-Jeng Wu Hsin-Chih Yeh Source Type: research

ASO Visual Abstract: Oncological Surgery during the COVID-19 pandemic-Effectiveness of Preoperative Screening and Factors Associated with Postoperative SARS-CoV-2 Infection
Ann Surg Oncol. 2022 Jan 20. doi: 10.1245/s10434-021-11242-0. Online ahead of print.NO ABSTRACTPMID:35059886 | DOI:10.1245/s10434-021-11242-0 (Source: Ann Oncol)
Source: Ann Oncol - January 21, 2022 Category: Cancer & Oncology Authors: Andr é Lopes Caroline B P Pastore Paula Deckers Izabela K M W Halla Ana Luiza Rezende Dias Marcos Vinicius Maia da Mata Adriana do Nascimento Martins Micaela Mazutti Viu Rossana Veronica Mendoza Lopez Alayne Domingues Yamada Source Type: research