Ann Oncol; +31 new citations
31 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Ann Oncol These pubmed results were generated on 2020/01/16PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: Ann Oncol)
Source: Ann Oncol - January 17, 2020 Category: Cancer & Oncology Tags: Report Source Type: research

ASO Author Reflections: Increase of Circulating Tumor Cells After Open Radical Nephrectomy Compared with Other Surgical Modalities.
PMID: 31933219 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - January 13, 2020 Category: Cancer & Oncology Authors: Haga N Tags: Ann Surg Oncol Source Type: research

18FDG-PET/CT Imaging in Breast Cancer Patients with Clinical Stage IIB or Higher : Commentary on "Overuse of Preoperative Staging of Patients Undergoing Neoadjuvant Chemotherapy for Breast Cancer" by Marissa K. Srour et al.
18FDG-PET/CT Imaging in Breast Cancer Patients with Clinical Stage IIB or Higher : Commentary on "Overuse of Preoperative Staging of Patients Undergoing Neoadjuvant Chemotherapy for Breast Cancer" by Marissa K. Srour et al. Ann Surg Oncol. 2020 Jan 13;: Authors: Groheux D, Hindié E PMID: 31933220 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - January 13, 2020 Category: Cancer & Oncology Authors: Groheux D, Hindié E Tags: Ann Surg Oncol Source Type: research

Technique for Robotic Transhiatal Esophagectomy.
Abstract Minimally invasive esophagectomy is increasing performed for cancers of the esophagus and gastroesophageal junction. This video demonstrates the setup and key steps for a robotic transhiatal esophagectomy with a cervical anastomosis. PMID: 31933221 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - January 13, 2020 Category: Cancer & Oncology Authors: Peng JS, Kukar M, Hochwald SN Tags: Ann Surg Oncol Source Type: research

ASO Author Reflections: Laparoscopic Caudate Resection in Advanced Cirrhosis: Are We Transferring the Pain from the Patient to the Surgeon?
PMID: 31933222 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - January 13, 2020 Category: Cancer & Oncology Authors: Vega EA, Conrad C Tags: Ann Surg Oncol Source Type: research

Margin Positivity in Resectable Esophageal Cancer: Are there Modifiable Risk Factors?
Abstract BACKGROUND: Patients with esophageal cancer have poor overall survival, with positive resection margins worsening survival. Margin positivity rates are used as quality measures in other malignancies, but modifiable risk factors are necessary to develop actionable targets for improvement. Our objectives were to (1) evaluate trends in esophageal cancer margin positivity, and (2) identify modifiable patient/hospital factors associated with margin positivity. METHODS: Patients who underwent esophagectomy from 2004 to 2015 were identified from the National Cancer Database. Trends in margin positivity by t...
Source: Ann Oncol - January 13, 2020 Category: Cancer & Oncology Authors: Schlick CJR, Khorfan R, Odell DD, Merkow RP, Bentrem DJ Tags: Ann Surg Oncol Source Type: research

Re: Modified Gastric Cancer AJCC Staging with a Classification Based on the Ratio of Regional Lymph Node Involvement: A Population-Based Cohort Study.
PMID: 31933224 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - January 13, 2020 Category: Cancer & Oncology Authors: Ammori BJ Tags: Ann Surg Oncol Source Type: research

Ann Oncol; +26 new citations
26 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Ann Oncol These pubmed results were generated on 2020/01/11PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: Ann Oncol)
Source: Ann Oncol - January 11, 2020 Category: Cancer & Oncology Tags: Report Source Type: research

Ann Oncol; +25 new citations
25 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Ann Oncol These pubmed results were generated on 2020/01/09PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: Ann Oncol)
Source: Ann Oncol - January 10, 2020 Category: Cancer & Oncology Tags: Report Source Type: research

Ann Oncol; +19 new citations
19 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Ann Oncol These pubmed results were generated on 2020/01/08PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: Ann Oncol)
Source: Ann Oncol - January 8, 2020 Category: Cancer & Oncology Tags: Report Source Type: research

Ann Oncol; +22 new citations
22 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Ann Oncol These pubmed results were generated on 2020/01/05PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: Ann Oncol)
Source: Ann Oncol - January 5, 2020 Category: Cancer & Oncology Tags: Report Source Type: research

Stereotactic Ablative Radiotherapy for the Management of Spinal Metastases: A Review.
Conclusions and Relevance: These findings suggest that spinal SABR may be an effective treatment option for well-selected patients with spinal metastases, achieving high rates of local tumor control with moderate rates of adverse effects. Optimal management should include review by a multidisciplinary care team. PMID: 31895403 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - January 2, 2020 Category: Cancer & Oncology Authors: Glicksman RM, Tjong MC, Neves-Junior WFP, Spratt DE, Chua KLM, Mansouri A, Chua MLK, Berlin A, Winter JD, Dahele M, Slotman BJ, Bilsky M, Shultz DB, Maldaun M, Szerlip N, Lo SS, Yamada Y, Vera-Badillo FE, Marta GN, Moraes FY Tags: JAMA Oncol Source Type: research

Reply to K.P. Weinfurt et al.
PMID: 31895615 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - January 2, 2020 Category: Cancer & Oncology Authors: Agochukwu NQ, Wittmann D, Boileau NR, Dunn RL, Montie J, Kim T, Miller DC, Peabody J, Carlozzi NE Tags: J Clin Oncol Source Type: research

Ann Oncol; +17 new citations
17 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Ann Oncol These pubmed results were generated on 2020/01/01PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: Ann Oncol)
Source: Ann Oncol - January 1, 2020 Category: Cancer & Oncology Tags: Report Source Type: research

What Has Been Will Be Again-Challenges in Post-Residency Radiation Oncology Employment.
PMID: 31836081 [PubMed - in process] (Source: Ann Oncol)
Source: Ann Oncol - December 16, 2019 Category: Cancer & Oncology Authors: McClelland S, Jagsi R Tags: Int J Radiat Oncol Biol Phys Source Type: research

Trends in the Number of Lymph Nodes Evaluated Among Patients with Pancreatic Neuroendocrine Tumors in the United States: A Multi-Institutional and National Database Analysis.
The objective of the current study was to investigate trends in the number of lymph nodes (LN) evaluated for pNET treatment at a nationwide level. METHODS: Patients undergoing surgery for pNET between 2000 and 2016 were identified in the U.S. Neuroendocrine Tumor Study Group (US-NETSG) database as well as the Surveillance, Epidemiology, and End Results (SEER) database. The number of LNs examined was evaluated over time. RESULTS: The median number of evaluated LNs increased roughly fourfold over the study period (US-NETSG, 2000: 3 LNs vs. 2016: 13 LNs; SEER, 2000: 3 LNs vs. 2016: 11 LNs, both p 
Source: Ann Oncol - December 14, 2019 Category: Cancer & Oncology Authors: Sahara K, Tsilimigras DI, Mehta R, Moro A, Paredes AZ, Lopez-Aguiar AG, Rocha F, Kanji Z, Weber S, Fisher A, Fields R, Krasnick BA, Idrees K, Smith PM, Poultsides GA, Makris E, Cho C, Beems M, Dillhoff M, Maithel SK, Endo I, Pawlik TM Tags: Ann Surg Oncol Source Type: research

Two-Stage Cytoreductive Surgery and Intraperitoneal Chemotherapy for Diffuse Malignant Peritoneal Mesothelioma: Predictors of Overall Survival in an Intention-to-Treat Series.
Abstract PURPOSE: Cytoreductive surgery with intraoperative hyperthermic intraperitoneal chemotherapy is standard of care for diffuse malignant peritoneal mesothelioma (DMPM), but there is variability among institutions in the administration of adjuvant chemotherapy. Characterization of the largest series of DMPM patients treated at a single institution and identification of the demographic, disease, and treatment factors associated with overall survival were sought. PATIENTS AND METHODS: All DMPM patients who underwent initial cytoreductive surgery with the intention to undergo intraperitoneal chemotherapy a...
Source: Ann Oncol - December 12, 2019 Category: Cancer & Oncology Authors: Leinwand JC, Taub RN, Chabot JA, Kluger MD Tags: Ann Surg Oncol Source Type: research

Perioperative Detection of Circulating Tumor Cells in Radical or Partial Nephrectomy for Renal Cell Carcinoma.
In this study CTCs were measured by the FISHMAN-R system, and CTCs drawn from a peripheral artery were collected just before and immediately after surgery. The number of pre- and postoperative CTCs and the perioperative changes in CTCs were measured for each surgical method. RESULTS: Six patients were excluded from the current analyses. Preoperative CTCs did not differ significantly by surgical approach (laparoscopic RN: 3.4 ± 4.2; laparoscopic PN: 3.4 ± 4.1; open RN: 7.7 ± 6.8; open PN: 6.0 ± 7.6; P = 0.19). Open RN resu...
Source: Ann Oncol - December 12, 2019 Category: Cancer & Oncology Authors: Haga N, Onagi A, Koguchi T, Hoshi S, Ogawa S, Akaihata H, Hata J, Hiraki H, Honda R, Tanji R, Matsuoka K, Kataoka M, Sato Y, Ishibashi K, Kojima Y Tags: Ann Surg Oncol Source Type: research

ASO Author Reflections: Depth of Invasion in Oral Cavity Squamous Cell Carcinoma-Past, Present, and Future.
PMID: 31832915 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - December 12, 2019 Category: Cancer & Oncology Authors: Liao CT, Yen TC Tags: Ann Surg Oncol Source Type: research

Esophagectomy for Esophageal Cancer in a Patient with Left Pulmonary Artery Sling.
CONCLUSIONS: The presence of LPAS in esophageal cancer surgery makes it difficult to dissect the left RLN nodes. We could safely perform curative esophagectomy for an ESCC patient with LPAS using the cervicothoracoscopic approach. PMID: 31832916 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - December 12, 2019 Category: Cancer & Oncology Authors: Takahashi K, Okamura A, Amada E, Otake R, Kozuki R, Toihata T, Imamura Y, Watanabe M Tags: Ann Surg Oncol Source Type: research

ASO Author Reflections: Trends in the Number of Lymph Nodes Evaluated Following Resection of Pancreatic Neuroendocrine Tumors-An Increasing Adoption of the AJCC Guidelines?
PMID: 31832917 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - December 12, 2019 Category: Cancer & Oncology Authors: Sahara K, Tsilimigras DI, Pawlik TM Tags: Ann Surg Oncol Source Type: research

ASO Author Reflections: How Should a Surgeon Care and Manage Cancer Metastasis?
PMID: 31832918 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - December 12, 2019 Category: Cancer & Oncology Authors: Zhang X, Li TS Tags: Ann Surg Oncol Source Type: research

ASO Author Reflections: Registry-Based Analysis of Radiation-Associated Angiosarcoma of the Breast Provides Unbiased Insights into this Disease.
PMID: 31832919 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - December 12, 2019 Category: Cancer & Oncology Authors: Salminen SH, Blomqvist CP Tags: Ann Surg Oncol Source Type: research

Cytomegalovirus viremia and resistance patterns in immunocompromised children: An 11-year experience.
Abstract We noted a recent increase in number of immunocompromised children with CMV viremia at our institution. The purpose of this study was to determine the frequency of CMV viremia in this population and evaluate factors associated with drug-resistant mutations. A retrospective review of immunocompromised hosts, 0-21 years of age, who had CMV viremia during 2007-2017. CMV viremia was detected using PCR assays. Genetic mutation assays were performed using PCR sequencing of the phosophotransferase UL 97 gene and the polymerase UL54 gene of CMV using Quest Diagnostics (San Juan Capistrano, CA, USA) or ARUP...
Source: Ann Oncol - December 12, 2019 Category: Cancer & Oncology Authors: Kim E, Asmar BI, Thomas R, Abdel-Haq N Tags: Pediatr Hematol Oncol Source Type: research

Lung Cancer Surveillance After Definitive Curative-Intent Therapy: ASCO Guideline.
Abstract PURPOSE: To provide evidence-based recommendations to practicing clinicians on radiographic imaging and biomarker surveillance strategies after definitive curative-intent therapy in patients with stage I-III non-small-cell lung cancer (NSCLC) and SCLC. METHODS: ASCO convened an Expert Panel of medical oncology, thoracic surgery, radiation oncology, pulmonary, radiology, primary care, and advocacy experts to conduct a literature search, which included systematic reviews, meta-analyses, randomized controlled trials, and prospective and retrospective comparative observational studies published from 2000...
Source: Ann Oncol - December 12, 2019 Category: Cancer & Oncology Authors: Schneider BJ, Ismaila N, Aerts J, Chiles C, Daly ME, Detterbeck FC, Hearn JWD, Katz SI, Leighl NB, Levy B, Meyers B, Murgu S, Nekhlyudov L, Santos ES, Singh N, Tashbar J, Yankelevitz D, Altorki N Tags: J Clin Oncol Source Type: research

Molecular Biomarkers in Localized Prostate Cancer: ASCO Guideline.
Abstract PURPOSE: This guideline provides recommendations for available tissue-based prostate cancer biomarkers geared toward patient selection for active surveillance, identification of clinically significant disease, choice of postprostatectomy adjuvant versus salvage radiotherapy, and to address emerging questions such as the relative value of tissue biomarkers compared with magnetic resonance imaging. METHODS: An ASCO multidisciplinary Expert Panel, with representatives from the European Association of Urology, American Urological Association, and the College of American Pathologists, conducted a systemat...
Source: Ann Oncol - December 12, 2019 Category: Cancer & Oncology Authors: Eggener SE, Rumble RB, Armstrong AJ, Morgan TM, Crispino T, Cornford P, van der Kwast T, Grignon DJ, Rai AJ, Agarwal N, Klein EA, Den RB, Beltran H Tags: J Clin Oncol Source Type: research

Is There a Role for Surgery in Treating Localized Esophageal Neuroendocrine Tumor?
PMID: 31828688 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - December 11, 2019 Category: Cancer & Oncology Authors: Deng HY Tags: Ann Surg Oncol Source Type: research

Reply to the Editor: "Is There a Role of Surgery in Treating Localized Esophageal Neuroendocrine Tumor?"
Reply to the Editor: "Is There a Role of Surgery in Treating Localized Esophageal Neuroendocrine Tumor?" Ann Surg Oncol. 2019 Dec 11;: Authors: Erdem S, Warschkow R, Worni M PMID: 31828689 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - December 11, 2019 Category: Cancer & Oncology Authors: Erdem S, Warschkow R, Worni M Tags: Ann Surg Oncol Source Type: research

The Suggestion of Revised Criteria for Endoscopic Resection of Differentiated-Type Submucosal Gastric Cancer.
In this study, we develop the revised criteria for ER of submucosal gastric cancer with the aim of minimizing LNM. METHODS: We analyzed the clinicopathological data of 2461 patients diagnosed with differentiated, submucosal gastric cancer who underwent surgery at three tertiary hospitals between March 2001 and December 2012, and re-analyzed the pathological slides of all patients. The depth of submucosal invasion was measured histopathologically in two different ways (the classic and alternative methods) to obtain accurate data. RESULTS: Of the enrolled subjects, 306 (17.0%) had LNM. The width of submucosal invas...
Source: Ann Oncol - December 11, 2019 Category: Cancer & Oncology Authors: Ma DW, Lee SJ, Kook MC, Park DY, Ahn S, Ryu KW, Choi IJ, Noh SH, Kim H, Lee YC, Kim JH Tags: Ann Surg Oncol Source Type: research

Intensified Neoadjuvant Chemoradiotherapy for Patients with Potentially Resectable Esophageal Cancer: A Retrospective Cohort Study.
CONCLUSIONS: Intensification of neoadjuvant chemoradiotherapy for patients with potentially resectable esophageal cancer is well tolerated, yielding high pathological complete response rates, but adverse events occurred frequently, and survival compared with conventional neoadjuvant chemoradiotherapy seems similar. Therefore, intensification of neoadjuvant chemoradiotherapy should not be routinely used. PMID: 31828691 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - December 11, 2019 Category: Cancer & Oncology Authors: Boers J, Joldersma A, van Dalsen AD, Wiegman EM, Schenk BE, de Graaf JC, Pierik EGJM, Timmer PR, de Groot JWB Tags: Ann Surg Oncol Source Type: research

Differences in Metastatic Pattern in Patients Presenting With or Without Obstructing Colorectal Cancer: A Retrospective Observational Study of 2595 Patients.
Abstract BACKGROUND: Little is known about metastatic patterns in patients with obstructing colorectal cancer (CRC). OBJECTIVE: The aim of this study was to determine if metastatic patterns in patients with CRC differ between patients with or without obstruction. METHODS: This single-center, observational, retrospective cohort study includes patients who underwent surgery for CRC between 2004 and 2015 in our hospital. Patients were divided into two groups-patients with or without obstructing CRC. All anatomic sites of distant metastases were reported. Differences in synchronous and metachronous metastase...
Source: Ann Oncol - December 10, 2019 Category: Cancer & Oncology Authors: Boeding JRE, Ramphal W, Crolla RMPH, Gobardhan PD, Schreinemakers JMJ Tags: Ann Surg Oncol Source Type: research

ASO Author Reflections: Systemic Immune-Inflammation Index (SII) as a Biomarker of Response to Neoadjuvant Therapy in Patients with Pancreatic Adenocarcinoma.
PMID: 31823171 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - December 10, 2019 Category: Cancer & Oncology Authors: Murthy P, Boone BA Tags: Ann Surg Oncol Source Type: research

Trends in Renal Tumor Surgery in the United States and Germany Between 2006 and 2014: Organ Preservation Rate Is Improving.
This study compared the implementation of NSS in the United States and Germany. METHODS: Data were derived from the National Inpatient Sample and from the Nationwide German Hospital Billing Database. All cases of NSS and radical nephrectomy from 2006 to 2014 were analyzed. To assess tumor stage distribution, data from the Surveillance, Epidemiology, and End Results database (United States) and from German cancer registries were used. RESULTS: The study identified 74,663 cases in the United States and 130,051 cases in Germany. The proportion of NSS for T1 tumors increased from 30.6 to 57% in the United States comp...
Source: Ann Oncol - December 10, 2019 Category: Cancer & Oncology Authors: Flegar L, Groeben C, Koch R, Baunacke M, Borkowetz A, Kraywinkel K, Thomas C, Huber J Tags: Ann Surg Oncol Source Type: research

Increase in Utilization of Nipple-Sparing Mastectomy for Breast Cancer: Indications, Complications, and Oncologic Outcomes.
In this study, we examine the indications, complications, and long-term outcomes of therapeutic NSM. METHODS: From 2003 to 2016, women undergoing NSM for invasive cancer or ductal carcinoma in situ (DCIS) were identified from a prospectively maintained database. Patient and disease characteristics were compared by procedure year, while complications were compared by procedure year using generalized mixed-effects models accounting for a random surgeon effect. Overall survival and time to recurrence were examined. RESULTS: Of the 467 therapeutic NSMs, 337 (72%) were invasive cancer, 126 (27%) were DCIS, and 4 (1%) ...
Source: Ann Oncol - December 10, 2019 Category: Cancer & Oncology Authors: Valero MG, Muhsen S, Moo TA, Zabor EC, Stempel M, Pusic A, Gemignani ML, Morrow M, Sacchini VS Tags: Ann Surg Oncol Source Type: research

Opioid Use after Breast-Conserving Surgery: Prospective Evaluation of Risk Factors for High Opioid Use.
CONCLUSIONS: Smoking, preoperative opioid use, bilateral oncoplastic surgery, ALND, use of surgical drains, high reported postoperative pain score, and receiving a higher OME discharge prescription are associated with higher postoperative opioid use. Given the wide variability of analgesic needs, these criteria should be used to guide the appropriate tailoring of opioid prescriptions. PMID: 31820211 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - December 9, 2019 Category: Cancer & Oncology Authors: Park KU, Kyrish K, Yi M, Bedrosian I, Caudle AS, Kuerer HM, Hunt KK, Miggins MV, DeSnyder SM Tags: Ann Surg Oncol Source Type: research

Microscopic Extracapsular Extension in Sentinel Lymph Nodes Does Not Mandate Axillary Dissection in Z0011-Eligible Patients.
CONCLUSIONS: In Z0011-eligible patients, nodal recurrence rates in patients with mECE are low after treatment with SLN biopsy alone, even in the absence of routine nodal radiation. The presence of mECE should not be considered a routine indication for ALND. PMID: 31820212 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - December 9, 2019 Category: Cancer & Oncology Authors: Barrio AV, Downs-Canner S, Edelweiss M, Van Zee KJ, Cody HS, Gemignani ML, Pilewskie ML, Plitas G, El-Tamer M, Kirstein L, Capko D, Patil S, Morrow M Tags: Ann Surg Oncol Source Type: research

Neoadjuvant Chemoradiotherapy with Cisplatin Plus Fluorouracil for Borderline Resectable Esophageal Squamous Cell Carcinoma.
This study evaluated the efficacy of neoadjuvant chemoradiotherapy (NACRT) with cisplatin plus fluorouracil (CF) and irradiation (40 Gy) for these patients. METHODS: The study cohort included 50 patients with BR-ESCC who received NACRT as the initial treatment and were allocated to one of two groups: patients who achieved curative resection (R0 group) or those who did not (Non-R0 group). The overall survival (OS), relapse-free survival (RFS), and pre-therapeutic predictive factors for Non-R0 were evaluated. RESULTS: Among the 50 patients, 22 (44%) achieved curative resection clinically. The median OS was sig...
Source: Ann Oncol - December 9, 2019 Category: Cancer & Oncology Authors: Suzuki T, Okamura A, Watanabe M, Mine S, Imamura Y, Asari T, Osumi H, Nakayama I, Ichimura T, Ogura M, Ooki A, Takahari D, Yamaguchi K, Chin K Tags: Ann Surg Oncol Source Type: research

An evaluation of the construction of the device along with the software for digital archiving, sending the data, and supporting the diagnosis of cervical cancer.
Abstract Cervical cancer is still an important cause of mortality among women in a number of countries. There are effective methods of prevention and early diagnosis, but they require well-trained medical professionals including cytologists. Within this project, we built a prototype of a new device together with implemented software using U-NET and CNN architectures of neural networks (ANN), to convert the currently used optical microscopes into fully independent scanning and evaluating systems for cytological samples. To evaluate the specificity and sensitivity of the system, 2058 (2000 normal and 58 abnormal sam...
Source: Ann Oncol - December 6, 2019 Category: Cancer & Oncology Authors: Lasyk Ł, Barbasz J, Żuk P, Prusaczyk A, Włodarczyk T, Prokurat E, Olszewski W, Bidziński M, Baszuk P, Gronwald J Tags: Contemp Oncol (Pozn) Source Type: research

Predictive Values of MRI and PET Derived Quantitative Parameters for Patterns of Failure in Both p16+ and p16- High Risk Head and Neck Cancer.
Abstract Purpose: FDG-PET adds to clinical factors, such tumor stage and p16 status, in predicting local (LF), regional (RF), and distant failure (DF) in poor prognosis locally advanced head and neck cancer (HNC) treated with chemoradiation. We hypothesized that MRI-based quantitative imaging (QI) metrics could add to clinical predictors of treatment failure more significantly than FDG-PET metrics. Materials and methods: Fifty four patients with poor prognosis HNCs who were enrolled in an IRB approved prospective adaptive chemoradiotherapy trial were analyzed. MRI-derived gross tumor volume (GTV), blood volume (BV...
Source: Ann Oncol - December 6, 2019 Category: Cancer & Oncology Authors: Cao Y, Aryal M, Li P, Lee C, Schipper M, Hawkins PG, Chapman C, Owen D, Dragovic AF, Swiecicki P, Casper K, Worden F, Lawrence TS, Eisbruch A, Mierzwa M Tags: Front Oncol Source Type: research

Neoadjuvant Therapy is Associated with Improved Survival in Borderline-Resectable Pancreatic Cancer.
Abstract BACKGROUND: Neoadjuvant therapy has shown value in various cancer types. The role of neoadjuvant therapy in pancreatic ductal adenocarcinoma (PDAC), however, remains unknown. The aim of the present work is to evaluate the effect of neoadjuvant therapy on the survival of patients with borderline-resectable PDAC. PATIENTS AND METHODS: Between 2004 and 2015, 7730 patients with resectable PDAC and 1980 patients with borderline-resectable PDAC were identified from the National Cancer Database (NCDB). Survival was compared between resectable and borderline-resectable patients. Survival and pathologic chara...
Source: Ann Oncol - December 4, 2019 Category: Cancer & Oncology Authors: Chawla A, Molina G, Pak LM, Rosenthal M, Mancias JD, Clancy TE, Wolpin BM, Wang J Tags: Ann Surg Oncol Source Type: research

Technique for Robotic Ivor Lewis Esophagectomy with 6-cm Linear Stapled Side-to-Side Anastomosis.
PMID: 31802298 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - December 4, 2019 Category: Cancer & Oncology Authors: Peng JS, Nurkin SJ, Hochwald SN, Kukar M Tags: Ann Surg Oncol Source Type: research

The 'TRIANGLE Operation' by Laparoscopy: Radical Pancreaticoduodenectomy with Major Vascular Resection for Borderline Resectable Pancreatic Head Cancer.
CONCLUSION: The 'triangle operation' for borderline resectable pancreatic head cancer can be achieved safely by laparoscopy in carefully selected patients.1-11 Proven experience in both open and laparoscopic pancreatic surgery is mandatory. PMID: 31802299 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - December 4, 2019 Category: Cancer & Oncology Authors: Rosso E, Zimmitti G, Iannelli A, Garatti M Tags: Ann Surg Oncol Source Type: research

ASO Author Reflections: What Is the Best Treatment for Gastric Cancer with Positive Peritoneal Lavage Cytology or Localized Peritoneum Metastasis?
PMID: 31802300 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - December 4, 2019 Category: Cancer & Oncology Authors: Yamaguchi T, Takashima A, Boku N Tags: Ann Surg Oncol Source Type: research

A comparison of clinical staging using the Lugano versus Ann Arbor classifications in Japanese patients with Hodgkin lymphoma.
CONCLUSION: Our data revealed a high concordance rate between the Lugano and Ann Arbor staging system in Japanese patients with HL. Because of its low diagnostic value, routine bone marrow examination might be unnecessary for staging when FDG-PET/CT is used as a substitute. PMID: 31802636 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - December 4, 2019 Category: Cancer & Oncology Authors: Makita S, Maruyama D, Maeshima AM, Taniguchi H, Yuda S, Toyoda K, Yamauchi N, Fukuhara S, Munakata W, Kobayashi Y, Kurihara H, Izutsu K, Tobinai K Tags: Asia Pac J Clin Oncol Source Type: research

ASO Author Reflections: Future Prospects of Neoadjuvant Chemotherapy for Gastric Cancer.
PMID: 31797227 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - December 3, 2019 Category: Cancer & Oncology Authors: Kano M, Matsubara H Tags: Ann Surg Oncol Source Type: research

CMS Hospital Compare System of Star Ratings and Surgical Outcomes Among Patients Undergoing Surgery for Cancer: Do the Ratings Matter?
CONCLUSION: The risk of FTR, 90-day mortality, and increased hospital expenditure were all higher at a 1-star hospital. Further research is needed to investigate barriers to care at 5-star-rated hospitals and to target specific interventions to improve outcomes at 1-star hospitals. PMID: 31792714 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - December 2, 2019 Category: Cancer & Oncology Authors: Mehta R, Paredes AZ, Tsilimigras DI, Farooq A, Sahara K, Merath K, Hyer JM, White S, Ejaz A, Tsung A, Dillhoff M, Cloyd JM, Pawlik TM Tags: Ann Surg Oncol Source Type: research

Prognostic Value of the Systemic Immune-Inflammation Index (SII) After Neoadjuvant Therapy for Patients with Resected Pancreatic Cancer.
CONCLUSION: Post-treatment SII may be a useful prognostic marker in PDAC patients receiving NAT. PMID: 31792715 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - December 2, 2019 Category: Cancer & Oncology Authors: Murthy P, Zenati MS, Al Abbas AI, Rieser CJ, Bahary N, Lotze MT, Zeh HJ, Zureikat AH, Boone BA Tags: Ann Surg Oncol Source Type: research

L1CAM Predicts Adverse Outcomes in Patients with Endometrial Cancer Undergoing Full Lymphadenectomy and Adjuvant Chemotherapy.
Abstract BACKGROUND: L1 cell adhesion molecule (L1CAM) has been established as an important predictor of poor survival of early-stage endometrial cancer patients. We investigated whether L1CAM remains a significant predictor of poor survival of patients with advanced-stage endometrial cancer undergoing extensive surgical staging and adjuvant chemotherapy. METHODS: We prepared tissue microarray (TMA) from surgical tissue specimens of 161 endometrial cancer patients who underwent full lymphadenectomy combined with adjuvant chemotherapy for patients at risk for recurrence, and evaluated expression of L1CAM using...
Source: Ann Oncol - December 2, 2019 Category: Cancer & Oncology Authors: Asano H, Hatanaka KC, Matsuoka R, Dong P, Mitamura T, Konno Y, Kato T, Kobayashi N, Ihira K, Nozaki A, Oku A, Matsuno Y, Hatanaka Y, Watari H Tags: Ann Surg Oncol Source Type: research

The Impact of Primary Tumor Location in Synchronous Metastatic Colorectal Cancer: Differences in Metastatic Sites and Survival.
Abstract PURPOSE: We explored differences in survival between primary tumor locations, hereby focusing on the role of metastatic sites in synchronous metastatic colorectal cancer (mCRC). METHODS: Data for patients diagnosed with synchronous mCRC between 1989 and 2014 were retrieved from the Netherlands Cancer registry. Relative survival and relative excess risks (RER) were analyzed by primary tumor location (right colon (RCC), left colon (LCC), and rectum). Metastatic sites were reported per primary tumor location. Survival was analyzed for metastatic sites combined and for single metastatic sites. RESUL...
Source: Ann Oncol - December 2, 2019 Category: Cancer & Oncology Authors: Brouwer NPM, van der Kruijssen DEW, Hugen N, de Hingh IHJT, Nagtegaal ID, Verhoeven RHA, Koopman M, de Wilt JHW Tags: Ann Surg Oncol Source Type: research

Assessment of unintended volume loss of six closed system transfer devices.
PMID: 31775580 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - November 27, 2019 Category: Cancer & Oncology Authors: Kulju S, McIntosh BA, Fuller HJ, Arnold T, Gunnar W Tags: J Oncol Pharm Pract Source Type: research