Our Response to COVID-19 as Endocrinologists and Diabetologists.
PMID: 32232480 [PubMed - in process] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 3, 2020 Category: Endocrinology Authors: Kaiser UB, Mirmira RG, Stewart PM Tags: J Clin Endocrinol Metab Source Type: research

Does Hormone Therapy Protect the Heart? It Is a Stressful Question.
PMID: 32215563 [PubMed - in process] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 28, 2020 Category: Endocrinology Authors: Santoro N Tags: J Clin Endocrinol Metab Source Type: research

Insulin Autoimmune Syndrome: A Case of Clopidogrel-induced Autoimmune Hypoglycemia.
CONCLUSIONS: This case highlights a case of severe IAS. Given the ubiquity of clopidogrel, IAS should be remembered as a rare adverse effect. PMID: 32182368 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 18, 2020 Category: Endocrinology Authors: Calder GL, Ward GM, Sachithanandan N, MacIsaac RJ Tags: J Clin Endocrinol Metab Source Type: research

Clinical and Genetic Characterization of 153 Patients with Persistent or Transient Congenital Hyperinsulinism.
CONCLUSIONS: The genetic variants found in this nationwide CHI cohort are in agreement with previous studies, mutations in the KATP channel genes being the major causes of the disease. Pathogenic CHI-associated variants were not identified in patients who were both diazoxide responsive and able to discontinue medication within the first 4 months. Therefore, our results support the notion that genetic testing should be focused on patients with inadequate response or prolonged need for medication. PMID: 32170320 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 15, 2020 Category: Endocrinology Authors: Männistö JME, Maria M, Raivo J, Kuulasmaa T, Otonkoski T, Huopio H, Laakso M Tags: J Clin Endocrinol Metab Source Type: research

CORRIGENDUM FOR "A Case of Hashimoto's Thyroiditis with Multiple Drug Resistance and High Expression of Efflux Transporters".
CORRIGENDUM FOR "A Case of Hashimoto's Thyroiditis with Multiple Drug Resistance and High Expression of Efflux Transporters". J Clin Endocrinol Metab. 2020 Apr 01;105(4): Authors: PMID: 32170861 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 15, 2020 Category: Endocrinology Tags: J Clin Endocrinol Metab Source Type: research

CORRIGENDUM FOR "Estimated Association Between Cytokines and the Progression to Diabetes: 10-year Follow-up From a Community-Based Cohort".
CORRIGENDUM FOR "Estimated Association Between Cytokines and the Progression to Diabetes: 10-year Follow-up From a Community-Based Cohort". J Clin Endocrinol Metab. 2020 Apr 01;105(4): Authors: PMID: 32170862 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 15, 2020 Category: Endocrinology Tags: J Clin Endocrinol Metab Source Type: research

Determining the Prevalence of Primary Aldosteronism in Patients With New-Onset Type 2 Diabetes and Hypertension.
This study aimed to detect the prevalence of PA in patients with new-onset type 2 diabetes (T2D) and hypertension and to explore the association between PA and diabetes. METHODS: A total of 256 outpatients with new-onset T2D and hypertension were screened for PA. Plasma aldosterone concentration (PAC), plasma renin activity (PRA) were measured. Patients with an aldosterone renin activity ratio (ARR) ≥ 30 ng/dL/ng/mL/h and PAC ≥ 15 ng/dL underwent confirmatory captopril challenge test (CCT) for PA. The diagnostic criteria for PA were, after CCT, (1) PAC decreased
Source: The Journal of Clinical Endocrinology and Metabolism - March 14, 2020 Category: Endocrinology Authors: Hu Y, Zhang J, Liu W, Su X Tags: J Clin Endocrinol Metab Source Type: research

CORRIGENDUM FOR "Hippocampal Neurochemical Profile and Glucose Transport Kinetics in Patients With Type 1 Diabetes".
CORRIGENDUM FOR "Hippocampal Neurochemical Profile and Glucose Transport Kinetics in Patients With Type 1 Diabetes". J Clin Endocrinol Metab. 2020 Apr 01;105(4): Authors: PMID: 32154889 [PubMed - in process] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 12, 2020 Category: Endocrinology Tags: J Clin Endocrinol Metab Source Type: research

Heterozygous Mutation (Q459R) in the Calcium-Sensing Receptor Gene Causes Familial Hypocalciuric Hypercalcemia 1 (FHH1).
CONCLUSION: A loss-of-function Q459R mutation in CASR in a family caused FHH1 characterized by elevated ionized calcium and PTH and low calcium excretion. The marked presence of CaSR at the membrane and inhibition of IP1 signaling in vitro suggest that calcimimetics may be functional in patients with this mutation, which seems to be a mild loss-of-function mutation associated with autosomal dominant transmission of FHH1. PMID: 32160303 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 12, 2020 Category: Endocrinology Authors: Boisen IM, Mos I, Lerche-Black EM, Juul A, Bräuner-Osborne H, Blomberg Jensen M Tags: J Clin Endocrinol Metab Source Type: research

Association of Polymorphisms in the Kisspeptin/GPR54 Pathway Genes With Risk of Early Puberty in Chinese Girls.
Abstract CONTEXT AND OBJECTIVE: This case control study was designed to investigate the association between mutation of 10 single nucleotide polymorphism (SNP) loci (rs1132506, rs5780218, rs192636495, rs4889, rs184749, rs12985070, rs708910, rs932491, rs8074995, and rs2306877) in all 5 genes (KISS1, GPR54, PLCB1, PRKCA, and ITPR1) in the kisspeptin/GPR54 pathway and the risk of early puberty in Chinese Han girls. DESIGN AND PARTICIPANTS: A total of 314 pairs of early puberty girls on their first visit to hospital and age-matched controls (± 3 months) were recruited. The genotypes of each SNP were determ...
Source: The Journal of Clinical Endocrinology and Metabolism - March 12, 2020 Category: Endocrinology Authors: Li D, Wu Y, Cheng J, Liu L, Li X, Chen D, Huang S, Wen Y, Ke Y, Yao Y, Su Z, Zhou L Tags: J Clin Endocrinol Metab Source Type: research

Fractures, Bone Mineral Density, and Final Height in Craniopharyngioma Patients with a Follow-up of 16 Years.
CONCLUSIONS: Men with craniopharyngioma are at higher risk than women for fractures. In patients with craniopharyngioma, a very low BMD (T-score ≤-2.5 or Z-score ≤-2.0) seems not to be a good predictor for fracture risk. PMID: 32145029 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 8, 2020 Category: Endocrinology Authors: van Santen SS, Olsson DS, van den Heuvel-Eibrink MM, Wijnen M, Hammarstrand C, Janssen JAMJL, Johansson G, van der Lely AJ, Neggers SJCMM Tags: J Clin Endocrinol Metab Source Type: research

Glycemic measures and development and resolution of nonalcoholic fatty liver disease in nondiabetic individuals.
CONCLUSIONS: Increased glycemic levels within the nondiabetic range, as well as progression from NGR to T2D or prediabetes, were adversely associated with development and improvement of NAFLD. PMID: 32144419 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 7, 2020 Category: Endocrinology Authors: Wang B, Li M, Zhao Z, Wang S, Lu J, Chen Y, Xu M, Wang W, Ning G, Bi Y, Wang T, Xu Y Tags: J Clin Endocrinol Metab Source Type: research

Gender differences in the response to short-term cold exposure in young adults.
Abstract CONTEXT: Cold exposure (CE) has been shown to enhance energy expenditure by activating brown adipose tissue thermogenesis and metabolism in humans. However, it remains to be elucidated if there are gender-specific differences in cold-induced thermogenesis and metabolism. OBJECTIVE: To study the impact of mild CE on resting energy expenditure (REE) and metabolism in males compared to females. SETTING: A cross-sectional study. PARTICIPANTS: 117 healthy young Caucasians participated in this study (58 males). Mean age was 25.1 ± 3.6 years and mean BMI 22.3 ± 1.7 kg/m...
Source: The Journal of Clinical Endocrinology and Metabolism - March 7, 2020 Category: Endocrinology Authors: Mengel LA, Seidl H, Brandl B, Skurk T, Holzapfel C, Stecher L, Claussnitzer M, Hauner H Tags: J Clin Endocrinol Metab Source Type: research

Inherited missense mutation occurred Arginine76 of SRY gene not account for familial 46, XY sex reversal.
CONCLUSION:: In contrast to sporadic cases, inherited single nucleotide variations (SNVs) of SRY are not the main cause of the severe phenotype of 46,XY sex reversal, and the enhancers of SOX9 should be investigated carefully in such patients. PMID: 32140723 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 6, 2020 Category: Endocrinology Authors: Wang N, Zhu W, Han B, Wang H, Zhu H, Chen Y, Chen Y, Liu J, Liu Y, Zhao S, Song H, Qiao J Tags: J Clin Endocrinol Metab Source Type: research

Inflammation triggered by saturated fat ingestion is linked to insulin resistance and hyperandrogenism in PCOS.
CONCLUSION: In PCOS, increases in NFκB activation and circulating CRP and decreases in IκBα protein following saturated fat ingestion are independent of obesity. Circulating MNC and excess adipose tissue are separate and distinct contributors to inflammation in this disorder. PMID: 32140727 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 6, 2020 Category: Endocrinology Authors: González F, Considine RV, Abdelhadi OA, Acton AJ Tags: J Clin Endocrinol Metab Source Type: research

References for ultrasound staging of breast maturation, Tanner breast staging, pubic hair and menarche in Norwegian girls.
CONCLUSION: Thelarche occurred at a slightly younger age when assessed with ultrasound compared to clinical Tanner staging, although the two methods had a very good agreement when determining pubertal breast maturation. A significant decrease of 2.8 months in age at menarche was observed during the past decade in Norwegian girls. PMID: 32140730 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 6, 2020 Category: Endocrinology Authors: Bruserud IS, Roelants M, Oehme NHB, Madsen A, Eide GE, Bjerknes R, Rosendahl K, Juliusson PB Tags: J Clin Endocrinol Metab Source Type: research

Relationship of anabolic hormones with motor unit characteristics in quadriceps muscle in healthy and frail ageing men.
CONCLUSION: Our data highlight the associations between androgen levels and the electrophysiological characteristics of older men, particularly in the frail. Clinical trials involving administration of androgens will help to elucidate the potential benefits of intervention on neuromuscular function and/or frailty status. PMID: 32133493 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 5, 2020 Category: Endocrinology Authors: Swiecicka A, Piasecki M, Stashuk D, Jones D, Wu F, McPhee J, Rutter MK Tags: J Clin Endocrinol Metab Source Type: research

Accuracy of laboratory tests for the diagnosis of Cushing's syndrome.
CONCLUSIONS: All of the included diagnostic tests for CS are highly sensitive and specific. It appears that the DST is the most sensitive while the UFC is less sensitive. The specificity of all first-line tests appears comparable. PMID: 32133504 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 5, 2020 Category: Endocrinology Authors: Galm BP, Qiao N, Klibanski A, Biller BMK, Tritos NA Tags: J Clin Endocrinol Metab Source Type: research

Serum Angiopoietin-like Protein 6, Risk of Type 2 Diabetes, and Response to Hyperglycemia: A Prospective Cohort Study.
Abstract CONTEXT: Angiopoietin-like protein 6 (ANGPTL6) is a hepatokine that improves insulin sensitivity in animals. However, serum ANGPTL6 concentration was found to be higher in human subjects with diabetes or metabolic syndrome in cross-sectional studies, implying that ANGPTL6 may be induced to counteract hyperglycemia. OBJECTIVE: We investigated whether serum ANGPTL6 could predict incident diabetes and explored whether glucose or insulin could regulate ANGPTL6 expression and secretion. DESIGN: This cohort study included adults without diabetes at baseline, who were followed-up every two years for in...
Source: The Journal of Clinical Endocrinology and Metabolism - March 3, 2020 Category: Endocrinology Authors: Fan KC, Wu HT, Wei JN, Chuang LM, Hsu CY, Yen IW, Lin CH, Lin MS, Shih SR, Wang SH, Chang TJ, Li HY Tags: J Clin Endocrinol Metab Source Type: research

Hormonal profiles of menstrual bleeding patterns during the luteal-follicular transition.
CONCLUSIONS: Self-reported bleeding patterns may provide insight into luteal phase Pd3G levels. First bleed appears to be the best choice for defining the end of the luteal phase and achieving hormonal consistency across transitions. PMID: 32115635 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 2, 2020 Category: Endocrinology Authors: Jacobson MH, Howards PP, Kesner JS, Meadows JW, Dominguez CE, Spencer JB, Darrow LA, Terrell ML, Marcus M Tags: J Clin Endocrinol Metab Source Type: research

Differential frequency of CYP2R1 variants across populations reveals pathway selection for vitamin D homeostasis.
CONCLUSIONS: CYP2R1 polymorphisms have important effects on vitamin D homeostasis, and the geographic variability of CYP2R1 alleles represents an adaptation to differential exposures to UVB irradiation from sunlight. PMID: 32115644 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 2, 2020 Category: Endocrinology Authors: Casella A, Long C, Zhou J, Lai M, O'Lear L, Caplan I, Levine MA, Roizen JD Tags: J Clin Endocrinol Metab Source Type: research

Recharacterizing The Metabolic State of Energy Balance in Thrifty and Spendthrift Phenotypes.
Abstract PURPOSE: The human thrifty phenotype hypothesis presupposes that lower 24-hour energy expenditure (24EE) during famine preserves body mass and promotes survival. The prevailing view defines thrifty individuals as having a lower 24EE during fasting. However, it is also plausible that the greater decline in 24EE during fasting in thrifty individuals is due to higher 24EE during energy balance conditions (ENBAL). Herein, we provide evidence that this is indeed the case. METHODS: In 108 healthy subjects, 24EE was measured in a whole-room indirect calorimeter both during ENBAL and 24h fasting conditions. ...
Source: The Journal of Clinical Endocrinology and Metabolism - March 2, 2020 Category: Endocrinology Authors: Hollstein T, Basolo A, Ando T, Votruba SB, Walter M, Krakoff J, Piaggi P Tags: J Clin Endocrinol Metab Source Type: research

Resting energy expenditure in obese women with primary hypothyroidism and appropriate levothyroxine replacement therapy.
CONCLUSIONS: This study demonstrated that obese hypothyroid women in LT4 therapy with normal serum TSH level compared to euthyroid controls, are characterized by reduced REE, in line with the hypothesis that standard LT4 replacement therapy may not fully correct metabolic alterations related to hypothyroidism. We are not able to exclude that this feature may be influenced by the modulation of insulin sensitivity at the liver site, induced by LT4 oral administration. PMID: 32119074 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 2, 2020 Category: Endocrinology Authors: Muraca E, Ciardullo S, Oltolini A, Zerbini F, Bianconi E, Perra S, Villa M, Cannistraci R, Castoldi G, Pizzi P, Manzoni G, Lattuada G, Perseghin G Tags: J Clin Endocrinol Metab Source Type: research

Interleukin-6 (IL-6) activates the NOTCH1 signaling pathway through E-proteins in endometriotic lesions.
CONCLUSIONS: IL-6 induced NOTCH1 expression is mediated by E-proteins in the ectopic GE cells, which may promote endometriotic lesion development. PMID: 32119078 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 2, 2020 Category: Endocrinology Authors: Song Y, Su RW, Joshi NR, Kim TH, Lessey BA, Jeong JW, Fazleabas AT Tags: J Clin Endocrinol Metab Source Type: research

Serum Androgens are Independent Predictors of Insulin Clearance But Not of Insulin Secretion in Women With Pcos.
CONCLUSIONS: In women with PCOS metabolic clearance of insulin is reduced, contributing to generating hyperinsulinemia. Serum androgens are independent predictors of this phenomenon. PMID: 32119099 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 2, 2020 Category: Endocrinology Authors: Tosi F, Dal Molin F, Zamboni F, Saggiorato E, Salvagno GL, Fiers T, Kaufman JM, Bonora E, Moghetti P Tags: J Clin Endocrinol Metab Source Type: research

Maternal Glucocorticoid Metabolism Across Pregnancy: A Potential Mechanism Underlying Fetal Glucocorticoid Exposure.
Abstract CONTEXT: Across pregnancy, maternal serum cortisol levels increase up to 3-fold. It is not known whether maternal peripheral cortisol metabolism and clearance change across pregnancy or influence fetal cortisol exposure and development. OBJECTIVES: The primary study objective was to compare maternal urinary glucocorticoid metabolites, as markers of cortisol metabolism and clearance, between the second and third trimester of pregnancy. Secondary objectives were to test associations of total maternal urinary glucocorticoid excretion, with maternal serum cortisol levels and offspring birth weight z scor...
Source: The Journal of Clinical Endocrinology and Metabolism - March 1, 2020 Category: Endocrinology Authors: Stoye DQ, Andrew R, Grobman WA, Adam EK, Wadhwa PD, Buss C, Entringer S, Miller GE, Boardman JP, Seckl JR, Keenan-Devlin LS, Borders AEB, Reynolds RM Tags: J Clin Endocrinol Metab Source Type: research

Mapping the Steroid Response to Major Trauma From Injury to Recovery: A Prospective Cohort Study.
Abstract CONTEXT: Survival rates after severe injury are improving, but complication rates and outcomes are variable. OBJECTIVE: This cohort study addressed the lack of longitudinal data on the steroid response to major trauma and during recovery. DESIGN: We undertook a prospective, observational cohort study from time of injury to 6 months postinjury at a major UK trauma centre and a military rehabilitation unit, studying patients within 24 hours of major trauma (estimated New Injury Severity Score (NISS)> 15). MAIN OUTCOME MEASURES: We measured adrenal and gonadal steroids in serum and 24-hour ...
Source: The Journal of Clinical Endocrinology and Metabolism - February 27, 2020 Category: Endocrinology Authors: Foster MA, Taylor AE, Hill NE, Bentley C, Bishop J, Gilligan LC, Shaheen F, Bion JF, Fallowfield JL, Woods DR, Bancos I, Midwinter MM, Lord JM, Arlt W Tags: J Clin Endocrinol Metab Source Type: research

Clinical and Molecular Analysis in 2 Families With Novel Compound Heterozygous SBP2 (SECISBP2) Mutations.
CONCLUSIONS: We report 2 additional families with mutations in the SBP2 gene, a rare inherited condition manifesting global selenoprotein deficiencies. Report of additional families with SBP2 deficiency and their evaluation over time is needed to determine the full spectrum of clinical manifestations in SBP2 deficiency and increase our understanding of the role played by SBP2 and selenoproteins in health and disease. PMID: 32084277 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - February 23, 2020 Category: Endocrinology Authors: Fu J, Korwutthikulrangsri M, Gönç EN, Sillers L, Liao XH, Alikaşifoğlu A, Kandemir N, Menucci MB, Burman KD, Weiss RE, Dumitrescu AM Tags: J Clin Endocrinol Metab Source Type: research

Twice as High Diet-Induced Thermogenesis After Breakfast vs Dinner On High-Calorie as Well as Low-Calorie Meals.
Abstract BACKGROUND: The question of whether there is daytime time variation in diet-induced thermogenesis (DIT) has not been clearly answered. Moreover, it is unclear whether a potential diurnal variation in DIT is preserved during hypocaloric nutrition. OBJECTIVE: We hypothesized that DIT varies depending on the time of day and explored whether this physiological regulation is preserved after low-calorie compared with high-calorie intake. DESIGN: Under blinded conditions, 16 normal-weight men twice underwent a 3-day in-laboratory, randomized, crossover study. Volunteers consumed a predetermined low-cal...
Source: The Journal of Clinical Endocrinology and Metabolism - February 21, 2020 Category: Endocrinology Authors: Richter J, Herzog N, Janka S, Baumann T, Kistenmacher A, Oltmanns KM Tags: J Clin Endocrinol Metab Source Type: research

GIP and GLP-1 Receptor Antagonism During a Meal in Healthy Individuals.
CONCLUSIONS: Endogenous GIP and GLP-1 lower postprandial plasma glucose excursions and stimulate insulin secretion but only endogenous GIP affects gallbladder motility. The two incretin hormones potentiate each other's effects in the control of postprandial glycemia in healthy men. PMID: 32077470 [PubMed - in process] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - February 21, 2020 Category: Endocrinology Authors: Gasbjerg LS, Helsted MM, Hartmann B, Sparre-Ulrich AH, Veedfald S, Stensen S, Lanng AR, Bergmann NC, Christensen MB, Vilsbøll T, Holst JJ, Rosenkilde MM, Knop FK Tags: J Clin Endocrinol Metab Source Type: research

Pharmacological Management of Osteoporosis in Postmenopausal Women: An Endocrine Society Guideline Update.
CONCLUSIONS: We reviewed findings from the meta-analysis and primary clinical trials assessing the efficacy of romosozumab, a monoclonal antibody targeting sclerostin, for the prevention of fractures and concluded that this agent can be considered a treatment option for postmenopausal women at very high risk for osteoporotic fracture. The romosozumab label has a boxed warning, recommending careful consideration by the treating clinician as to cardiovascular risk profile in the individual woman who might receive this agent, since clinical trial data from an active comparator study show an imbalance in serious cardiovascular...
Source: The Journal of Clinical Endocrinology and Metabolism - February 20, 2020 Category: Endocrinology Authors: Shoback D, Rosen CJ, Black DM, Cheung AM, Murad MH, Eastell R Tags: J Clin Endocrinol Metab Source Type: research

Letter to the Editor: "Cardiovascular Effects of Pioglitazone or Sulfonylureas According to Pretreatment Risk: Moving Toward Personalized Care".
Letter to the Editor: "Cardiovascular Effects of Pioglitazone or Sulfonylureas According to Pretreatment Risk: Moving Toward Personalized Care". J Clin Endocrinol Metab. 2020 Mar 01;105(3): Authors: de Carvalho LSF, Coelho OR, Sposito AC PMID: 32036386 [PubMed - in process] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - February 10, 2020 Category: Endocrinology Authors: de Carvalho LSF, Coelho OR, Sposito AC Tags: J Clin Endocrinol Metab Source Type: research

Response to Letter to the Editor: "Cardiovascular Effects of Pioglitazone or Sulfonylureas According to Pretreatment Risk: Moving Toward Personalized Care".
Response to Letter to the Editor: "Cardiovascular Effects of Pioglitazone or Sulfonylureas According to Pretreatment Risk: Moving Toward Personalized Care". J Clin Endocrinol Metab. 2020 Mar 01;105(3): Authors: Vaccaro O, Nicolucci A, Lucisano G, Masulli M, Riccardi G PMID: 32036387 [PubMed - in process] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - February 10, 2020 Category: Endocrinology Authors: Vaccaro O, Nicolucci A, Lucisano G, Masulli M, Riccardi G Tags: J Clin Endocrinol Metab Source Type: research

Insight into the Ontogeny of GnRH Neurons from Patients Born Without a Nose.
CONCLUSIONS: Patients with arhinia teach us that the GnRH neuron, a key gatekeeper of the reproductive axis, is associated with, but may not depend on, olfactory structures for normal migration and function, and more broadly, illustrate the power of extreme human phenotypes in answering fundamental questions about human embryology. PMID: 32034419 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - February 8, 2020 Category: Endocrinology Authors: Delaney A, Volochayev R, Meader B, Lee J, Almpani K, Noukelak GY, Henkind J, Chalmers L, Law JR, Williamson KA, Jacobsen CM, Buitrago TP, Perez O, Cho CH, Kaindl A, Rauch A, Steindl K, Garcia JE, Russell BE, Prasad R, Mondal UK, Reigstad HM, Clements S, K Tags: J Clin Endocrinol Metab Source Type: research

Rate and Extent of Recovery from Reproductive and Cardiac Dysfunction Due to Androgen Abuse in Men.
CONCLUSION: Suppressed testicular and cardiac function due to androgen abuse is effectively fully reversible (apart from testis volume and serum SHBG) with recovery taking between 6 to 18 months after ceasing androgen intake with possible cumulative effects on spermatogenesis. Suppressed serum AMH, LH and FSH represent convenient, useful and underutilized markers of recovery from androgen abuse. PMID: 32030409 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - February 7, 2020 Category: Endocrinology Authors: Shankara-Narayana N, Yu C, Savkovic S, Desai R, Fennell C, Turner L, Jayadev V, Conway AJ, Kockx M, Ridley L, Kritharides L, Handelsman DJ Tags: J Clin Endocrinol Metab Source Type: research

Distribution of body hair in young Australian women and associations with serum androgen concentrations.
Abstract CONTEXT: An important element of the diagnosis of polycystic ovary syndrome is hyperandrogenism. OBJECTIVE: To determine the distribution of modified Ferriman-Gallwey (mF-G) scores, as a measure of facial and body hair growth, and associations between the mF-G scores and serum androgen concentrations, including 11-oxygenated androgens. DESIGN: Cross-sectional study of non-health-care-seeking women, aged 18-39 years, recruited from the eastern states of Australia between November 2016 and July 2017. PARTICIPANTS AND MEASUREMENTS: Participants provided an mF-G self-assessment that corresponde...
Source: The Journal of Clinical Endocrinology and Metabolism - February 6, 2020 Category: Endocrinology Authors: Skiba MA, Bell RJ, Islam RM, Karim N, Davis SR Tags: J Clin Endocrinol Metab Source Type: research

Once-weekly somapacitan is effective and well tolerated in adults with GH deficiency: a randomized phase 3 trial.
CONCLUSIONS: In AGHD patients somapacitan administered once-weekly demonstrated superiority over placebo, and overall treatment effects and safety of somapacitan were in accordance with known effects and safety of GH replacement for up to 86 weeks of treatment. Somapacitan may provide an effective alternative to daily GH in AGHD. PMID: 32022863 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - February 5, 2020 Category: Endocrinology Authors: Johannsson G, Gordon MB, Rasmussen MH, Holme Håkonsson I, Karges W, Sværke C, Tahara S, Takano K, Biller BMK Tags: J Clin Endocrinol Metab Source Type: research

Mapping the Associations of the Plasma Lipidome with Insulin Resistance and Response to an Oral Glucose Tolerance Test.
CONCLUSIONS: The plasma lipidome and changes in lipid levels during an OGTT were associated with indices of insulin resistance. These findings underlie the involvement of molecular lipid species in the pathogenesis of insulin resistance and possibly crosstalk between insulin resistance and sex-specific regulation of lipid metabolism. PMID: 32016362 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - February 4, 2020 Category: Endocrinology Authors: Beyene HB, Hamley S, Giles C, Huynh K, Smith A, Cinel M, Mellet NA, Morales-Scholz MG, Kloosterman D, Howlett KF, Kowalski GM, Shaw CS, Magliano DJ, Bruce CR, Meikle PJ Tags: J Clin Endocrinol Metab Source Type: research

Serum Anti-M üllerian Hormone In The Prediction Of Response To hCG Stimulation In Children With DSD.
Serum Anti-Müllerian Hormone In The Prediction Of Response To hCG Stimulation In Children With DSD. J Clin Endocrinol Metab. 2020 Feb 04;: Authors: Lucas-Herald AK, Kyriakou A, Alimussina M, Guaragna-Filho G, Diver LA, McGowan R, Smith K, McNeilly JD, Ahmed SF Abstract INTRODUCTION: The relationship between serum anti-Müllerian hormone (AMH) and the testosterone response to hCG stimulation test is unclear. METHODS: Children who had hCG stimulation tests in one tertiary centre between 2001-2018 were included (n,138). Serum testosterone (T) was measured before (D1) and after 3 d...
Source: The Journal of Clinical Endocrinology and Metabolism - February 4, 2020 Category: Endocrinology Authors: Lucas-Herald AK, Kyriakou A, Alimussina M, Guaragna-Filho G, Diver LA, McGowan R, Smith K, McNeilly JD, Ahmed SF Tags: J Clin Endocrinol Metab Source Type: research

Ten years of very infrequent zoledronate therapy in older women: an open-label extension of a randomized trial.
CONCLUSIONS: These results suggest that zoledronate 5mg administered at a 5.5-year interval prevents bone loss over almost 11 years. Clinical trials to investigate whether very infrequent treatment with zoledronate reduces fracture risk are justified. PMID: 32016386 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - February 4, 2020 Category: Endocrinology Authors: Grey A, Horne A, Gamble G, Mihov B, Reid IR, Bolland M Tags: J Clin Endocrinol Metab Source Type: research

The Association between Heart Rate and Glycemic Status in the National Health and Nutrition Examination Surveys.
Abstract CONTEXT: Evidence suggests that heart rate (HR) is a prognostic factor for cardiovascular disease, for which persons with diabetes are at increased risk. OBJECTIVE: To determine the association between heart rate and glycemic status in a nationally representative sample of U.S. adults, and, among adults with diagnosed diabetes, the association between heart rate and A1c level. DESIGN: Cross-sectional study. SETTING: National Health and Nutrition Examination Surveys, 2011-2016. PARTICIPANTS: U.S. general adult (age ≥20 years) population who had information on glycemic status based on...
Source: The Journal of Clinical Endocrinology and Metabolism - February 4, 2020 Category: Endocrinology Authors: Casagrande SS, Cowie CC, Sosenko JM, Mizokami-Stout K, Boulton AJM, Pop-Busui R Tags: J Clin Endocrinol Metab Source Type: research

Circulating lysophosphatidylcholines in early pregnancy and risk of gestational diabetes in Chinese women.
This study aimed to explore associations of lysophosphatidylcholines (LPCs) in early pregnancy with gestational diabetes mellitus (GDM), and whether LPCs mediated the association of bile acids with GDM risk or had an interactive effect with bile acids on GDM risk. DESIGN: We conducted a 1:1 nested case-control study (n=486) from a large prospective pregnant women cohort in urban Tianjin, China. Blood samples were collected at their first antenatal care visit (median at 10th gestational weeks). LPCs were measured by liquid chromatography-tandem mass spectrometry analysis. Conditional binary logistic regression and rest...
Source: The Journal of Clinical Endocrinology and Metabolism - February 4, 2020 Category: Endocrinology Authors: Liu J, Li J, Li S, Leng J, Li W, Yang W, Huo X, Chen L, Ma RCW, Hu G, Fang Z, Yang X Tags: J Clin Endocrinol Metab Source Type: research

Long noncoding RNA HUPCOS promotes follicular fluid androgen excess in PCOS patients via aromatase inhibition.
CONCLUSIONS: Our findings suggested that HUPCOS mediated androgen excess in follicular fluid of PCOS patients by suppressing aromatase expression via interaction with RBPMS. PMID: 32016412 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - February 4, 2020 Category: Endocrinology Authors: Che Q, Liu M, Zhang D, Lu Y, Xu J, Lu X, Cao X, Liu Y, Dong X, Liu S Tags: J Clin Endocrinol Metab Source Type: research

Oxyntomodulin and glicentin may predict the effect of bariatric surgery on food preferences and weight loss.
n A Abstract BACKGROUND: Alterations in several gastrointestinal hormones are implicated in the postoperative suppression of food intake leading to weight loss after Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG). The aim was to evaluate changes in responses of gastrointestinal hormones after RYGB and SG and the associations of these changes with weight loss, energy intake, and food preferences. METHODS: Forty-two subjects with severe obesity were included (32 RYGB; 10 SG). Postprandial responses of glicentin, oxyntomodulin, GLP-1, PYY, and ghrelin were measured before and 6 months after surgery....
Source: The Journal of Clinical Endocrinology and Metabolism - February 4, 2020 Category: Endocrinology Authors: Nielsen MS, Ritz C, Wewer Albrechtsen NJ, Holst JJ, le Roux CW, Sjödin A Tags: J Clin Endocrinol Metab Source Type: research

AMH is higher across the menstrual cycle in early post-menarchal girls than in ovulatory women.
Abstract CONTEXT: Adolescents have more small, growing follicles and larger ovaries than normal women and are prone to anovulatory cycles (ANOV). It is unknown if a higher antral follicle count (AFC) per se contributes to ANOV in early post-menarchal girls. OBJECTIVE: To determine the relationship between AMH (an AFC biomarker), other reproductive hormones, and ANOV in post-menarchal girls and to compare AMH in girls and regularly cycling adults. METHODS: 23 girls (1.7 ± 0.2 yrs post-menarche) and 32 historic adult controls (
Source: The Journal of Clinical Endocrinology and Metabolism - February 4, 2020 Category: Endocrinology Authors: Ortega MT, Carlson L, McGrath JA, Kangarloo T, Adams JM, Sluss PM, Lambert-Messerlian G, Shaw ND Tags: J Clin Endocrinol Metab Source Type: research

Functional analyses of HNF1A-MODY variants refine the interpretation of identified sequence variants.
sh;rkhaug L Abstract CONTEXT: While rare variants of the hepatocyte nuclear factor-1 alpha (HNF1A) gene can cause Maturity-onset diabetes of the young (HNF1A-MODY), other variants can be risk factors for the development of type 2 diabetes. As has been suggested by the American College of Medical Genetics (ACMG) guidelines for variant interpretation, functional studies provide strong evidence to classify a variant as pathogenic. OBJECTIVE: We hypothesized that a functional evaluation can improve the interpretation of the HNF1A variants in our Czech MODY Registry. DESIGN, SETTINGS AND PARTICIPANTS: We stud...
Source: The Journal of Clinical Endocrinology and Metabolism - February 4, 2020 Category: Endocrinology Authors: Malikova J, Kaci A, Dusatkova P, Aukrust I, Torsvik J, Vesela K, Kankova PD, Njølstad PR, Pruhova S, Bjørkhaug L Tags: J Clin Endocrinol Metab Source Type: research

Direct Oral Anticoagulants in Atrial Fibrillation Patients with Concomitant Hyperthyroidism.
CONCLUSION: Among NVAF Asian patients with concomitant hyperthyroidism, DOACs may be an effective and safer alternative to warfarin. Thromboprophylaxis with DOACs may be considered for such patients, and it is important to validate this finding in further prospective study. PMID: 32009154 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - February 3, 2020 Category: Endocrinology Authors: Chan YH, Wu LS, See LC, Liu JR, Chang SH, Chao TF, Yeh YH, Kuo CT, Lee HF, Lip GYH Tags: J Clin Endocrinol Metab Source Type: research

Longitudinal Changes in the Relationship Between Hemoglobin A1c and Glucose Tolerance Across Pregnancy and Postpartum.
Abstract OBJECTIVE: To characterize the relationship between hemoglobin A1c (HbA1c) levels and glucose tolerance across pregnancy and postpartum. DESIGN AND PARTICIPANTS: In a longitudinal study of pregnant women with gestational diabetes risk factors (N=102), we performed oral glucose tolerance testing (OGTT) and HbA1c measurements at 10-15 weeks gestation, 24-30 weeks gestation (N=73), and 6-24 weeks postpartum (N=42). Complete blood counts were obtained from clinical records. We calculated HbA1c-estimated average glucose levels and compared them with mean OGTT glucose levels (average of fasting, 1- and 2-h...
Source: The Journal of Clinical Endocrinology and Metabolism - February 3, 2020 Category: Endocrinology Authors: Edelson PK, James KE, Leong A, Arenas J, Cayford M, Callahan MJ, Bernstein SN, Tangren JS, Hivert MF, Higgins JM, Nathan DM, Powe CE Tags: J Clin Endocrinol Metab Source Type: research

Metabolic and Genetic Determinants of Glucose Shape After Oral Challenge in Obese Youths: A Longitudinal Study.
rio S Abstract CONTEXT: The time-to-glucose-peak following the oral glucose tolerance test (OGTT) is a highly reproducible marker for diabetes risk. In obese youths, we lack evidence for the mechanisms underlying the effects of the TCF7L2 rs7903146 variant on glucose peak. METHODS: We analyzed the metabolic phenotype and the genotype for the TCF7L2 rs7903146 in 630 obese youths with normal (NGT) and impaired (IGT) glucose tolerance. Participants underwent a 3-hour, 9-point OGTT to estimate, using the oral minimal model, the disposition index (DI), the static (φstatic) and dynamic (φdynamic) components...
Source: The Journal of Clinical Endocrinology and Metabolism - January 25, 2020 Category: Endocrinology Authors: Galderisi A, Tricò D, Dalla Man C, Santoro N, Pierpont B, Groop L, Cobelli C, Caprio S Tags: J Clin Endocrinol Metab Source Type: research

Effect of chronic pancreatitis on complications and mortality in DM patients: A 10-year nationwide cohort study.
Abstract CONTEXT: Chronic pancreatitis (CP), is a long-term inflammation of the pancreatic parenchyma, might increase risk of a hyperglycemia crisis or hypoglycemia in patients with diabetes mellitus (DM), but the relationship has not been previously investigated. OBJECTIVE: To investigate the risk of diabetic ketoacidosis (DKA), hyperglycemic hyperosmolar state (HHS), hypoglycemia, and long-term outcomes in DM patients with CP. DESIGN: A population-based cohort study. SETTING AND PARTICIPANTS: Tapping Taiwan`s National Health Insurance Research Database, we identified 506 DM patients with newly dia...
Source: The Journal of Clinical Endocrinology and Metabolism - January 24, 2020 Category: Endocrinology Authors: Lin CH, Yeh NC, Wang JJ, Ho CH, Her SH, Tsay WI, Chien CC Tags: J Clin Endocrinol Metab Source Type: research