The Journal of Clinical Endocrinology and Metabolism 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Colorectal Cancer and Subsequent Diabetes Risk: A Population-based Cohort Study in Taiwan
CONCLUSION: Patients with CRC are associated with an elevated risk of diabetes mellitus, and long-term chemotherapy, particularly involving capecitabine, increases diabetes mellitus risk. Thus, monitoring blood glucose levels is crucial for patients with CRC, especially during extended chemotherapy.PMID:38661006 | DOI:10.1210/clinem/dgae257 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 25, 2024 Category: Endocrinology Authors: Hsin-Yin Hsu Yih-Jong Chern Min-Shu Hsu Tzu-Lin Yeh Ming-Chieh Tsai Jing-Rong Jhuang Cheng-Tzu Hsieh Chun-Ju Chiang Wen-Chung Lee Lee-Ching Hwang Kuo-Liong Chien Source Type: research
A Body Shape Index as a Simple Anthropometric Marker of Abdominal Obesity and Risk of Cardiovascular Events
CONCLUSIONS: High ABSI is independently associated with incidence of cardiovascular events. ABSI calculation should be performed for evaluation of risk of cardiovascular events.PMID:38661044 | DOI:10.1210/clinem/dgae282 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 25, 2024 Category: Endocrinology Authors: Masato Kajikawa Tatsuya Maruhashi Shinji Kishimoto Takayuki Yamaji Takahiro Harada Yusuke Saito Aya Mizobuchi Shunsuke Tanigawa Yukiko Nakano Kazuaki Chayama Chikara Goto Farina Mohamad Yusoff Ayumu Nakashima Yukihito Higashi Source Type: research
Clinical Activity of Selpercatinib in RET-mutant Pheochromocytoma
CONCLUSION: These data support selpercatinib as an effective therapy against RET-mutant pheochromocytoma, adding to the diversity of RET-activated tumor types that may benefit from targeted RET inhibition.PMID:38661071 | DOI:10.1210/clinem/dgae283 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 25, 2024 Category: Endocrinology Authors: Barbara Deschler-Baier Bhavana Konda Erminia Massarelli Mimi I Hu Lori J Wirth Xiaojian Xu Jennifer Wright Roderick J Clifton-Bligh Source Type: research
Long-term cumulative incidence of clinically diagnosed retinopathy in the Finnish Diabetes Prevention Study
CONCLUSION: A higher cumulative HbA1c was significantly associated with a higher risk of retinopathy. No evidence was found for a beneficial effect of a 4-year lifestyle intervention on the long-term occurrence of clinically diagnosed retinopathy during a median of 22-year follow-up.PMID:38661084 | DOI:10.1210/clinem/dgae287 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 25, 2024 Category: Endocrinology Authors: Kai Kaarniranta Mikko Valtanen Sirkka Kein änen-Kiukaanniemi Jaakko Tuomilehto Jaana Lindstr öm Matti Uusitupa Source Type: research
Patient-Reported Outcomes in Autosomal Dominant Osteopetrosis: Findings from the Osteopetrosis Registry Study
CONCLUSIONS: Data from this registry demonstrate the broad spectrum of ADO disease severity and high impact on health-related quality of life in adults with ADO.PMID:38661205 | DOI:10.1210/clinem/dgae285 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 25, 2024 Category: Endocrinology Authors: Lynda E Polgreen Eva Villa-Lopez Liz Chen Ziyue Liu Amy Katz Corinne Parks-Schenck Marian Hart Erik A Imel Michael J Econs Source Type: research
Prepubertal children with obesity have high free IGF-1 levels and accelerated growth despite reduced pappalysin levels
CONCLUSION: Increased circulating total and free IGF-I, insulin and IGF-II may all contribute to the increased rate of prepubertal growth and bone maturation observed in children with obesity, with STC2 possibly being involved.PMID:38662803 | DOI:10.1210/clinem/dgae288 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 25, 2024 Category: Endocrinology Authors: Álvaro Martín-Rivada Gabriel Á Martos-Moreno Santiago Guerra-Cantera Ana Campillo-Calatayud Claus Oxvig Jan Frystyk Julie A Chowen Vicente Barrios Jes ús Argente Source Type: research
Identification of Eukaryotic Translation Initiation Factor 4B as a Novel Candidate Gene for Congenital Hypothyroidism
CONCLUSION: These experimental data supported a role for EIF4B function in the pathogenesis of the hypothyroid phenotype seen in CH patients. Our work indicated that EIF4B was identified as a novel candidate gene in CH. EIF4B is essential for animal survival, but further studies are needed to validate its role in the pathogenesis of CH.PMID:38654471 | DOI:10.1210/clinem/dgae270 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 24, 2024 Category: Endocrinology Authors: Feng Sun Rui-Jia Zhang Ya Fang Cheng-Yan Yan Chang-Run Zhang Feng-Yao Wu Rui-Meng Yang Bing Han Huai-Dong Song Shuang-Xia Zhao Source Type: research
Inflammation-based scores in patients with pheochromocytoma
CONCLUSIONS: Inflammation-based scores in patients with pheochromocytoma showed pro-inflammatory changes that correlated with plasma metanephrine levels and are ameliorated by adrenalectomy and α-blockade.PMID:38655872 | DOI:10.1210/clinem/dgae284 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 24, 2024 Category: Endocrinology Authors: Chiara Parazzoli Alessandro Prete Vittoria Favero Carmen Aresta Valentina Pucino John Ayuk Miriam Asia Yasir S Elhassan Iacopo Chiodini Cristina L Ronchi Source Type: research
Establishment of Human Pituitary Neuroendocrine Tumor Derived Organoid and Its Pilot Application for Drug Screening
CONCLUSION: The established PDOs, retaining typical features of parental tumors, indicate a translational significance in innovating personalized treatment for refractory PitNETs.PMID:38656317 | DOI:10.1210/clinem/dgae228 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 24, 2024 Category: Endocrinology Authors: Run Cui Hao Duan Wanming Hu Chang Li Sheng Zhong Lun Liang Siyu Chen Hongrong Hu Zhenqiang He Zhenning Wang Xiaoyu Guo Zexin Chen Cong Xu Yu Zhu Yinsheng Chen Ke Sai Qunying Yang Chengcheng Guo Yonggao Mou Xiaobing Jiang Source Type: research
Identification of Eukaryotic Translation Initiation Factor 4B as a Novel Candidate Gene for Congenital Hypothyroidism
CONCLUSION: These experimental data supported a role for EIF4B function in the pathogenesis of the hypothyroid phenotype seen in CH patients. Our work indicated that EIF4B was identified as a novel candidate gene in CH. EIF4B is essential for animal survival, but further studies are needed to validate its role in the pathogenesis of CH.PMID:38654471 | DOI:10.1210/clinem/dgae270 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 24, 2024 Category: Endocrinology Authors: Feng Sun Rui-Jia Zhang Ya Fang Cheng-Yan Yan Chang-Run Zhang Feng-Yao Wu Rui-Meng Yang Bing Han Huai-Dong Song Shuang-Xia Zhao Source Type: research
Inflammation-based scores in patients with pheochromocytoma
CONCLUSIONS: Inflammation-based scores in patients with pheochromocytoma showed pro-inflammatory changes that correlated with plasma metanephrine levels and are ameliorated by adrenalectomy and α-blockade.PMID:38655872 | DOI:10.1210/clinem/dgae284 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 24, 2024 Category: Endocrinology Authors: Chiara Parazzoli Alessandro Prete Vittoria Favero Carmen Aresta Valentina Pucino John Ayuk Miriam Asia Yasir S Elhassan Iacopo Chiodini Cristina L Ronchi Source Type: research
Establishment of Human Pituitary Neuroendocrine Tumor Derived Organoid and Its Pilot Application for Drug Screening
CONCLUSION: The established PDOs, retaining typical features of parental tumors, indicate a translational significance in innovating personalized treatment for refractory PitNETs.PMID:38656317 | DOI:10.1210/clinem/dgae228 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 24, 2024 Category: Endocrinology Authors: Run Cui Hao Duan Wanming Hu Chang Li Sheng Zhong Lun Liang Siyu Chen Hongrong Hu Zhenqiang He Zhenning Wang Xiaoyu Guo Zexin Chen Cong Xu Yu Zhu Yinsheng Chen Ke Sai Qunying Yang Chengcheng Guo Yonggao Mou Xiaobing Jiang Source Type: research
Increased prevalence of germline pathogenic CHEK2 variants in individuals with pituitary adenomas
CONCLUSIONS: This is the first study to suggest a role for the breast cancer predisposition gene, CHEK2, in pituitary tumorigenesis, with pathogenic/likely pathogenic variants found in 3% of patients with pituitary adenomas. As pituitary adenomas are relatively common and typically lack classical autosomal dominant family histories, risk alleles - such as these variants found in CHEK2 - might be a significant contributor to pituitary adenoma risk in the general population.PMID:38651569 | DOI:10.1210/clinem/dgae268 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 23, 2024 Category: Endocrinology Authors: Sunita M C De Sousa Ann McCormack Andreas Orsmond Angeline Shen Christopher J Yates Roderick Clifton-Bligh Stephen Santoreneos James King Jinghua Feng John Toubia David J Torpy Hamish S Scott Source Type: research
Medullary Thyroid Cancer: Single Institute Experience over Three Decades and Risk Factors for Recurrence
CONCLUSION: One of 4 patients undergoing surgery for MTC will recur. Risk factors associated with recurrence are male gender, lateral LN metastasis and high/highest MTC risk level mutations, but not necessarily surgery type. Preoperative calcitonin>2,175 pg/mL is suggestive of advanced disease and should prompt further evaluation.PMID:38651609 | DOI:10.1210/clinem/dgae279 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 23, 2024 Category: Endocrinology Authors: Sara Abou Azar Joseph Tobias Megan Applewhite Peter Angelos Xavier M Keutgen Source Type: research
Approach to the patient: Concept and application of targeted radiotherapy in the paraganglioma patient
J Clin Endocrinol Metab. 2024 Apr 23:dgae252. doi: 10.1210/clinem/dgae252. Online ahead of print.ABSTRACTParagangliomas can metastasize, posing potential challenges in both symptomatic management and disease control. Systemic targeted radiotherapies using 131I-MIBG and 177Lu-DOTATATE are a mainstay in the treatment of metastatic paragangliomas. This clinical scenario and discussion aim to enhance physicians' knowledge of the stepwise approach to treat these patients with paraganglioma targeted radiotherapies. It comprehensively discusses current approaches to selecting paraganglioma patients for targeted radiotherapies and...
Source: The Journal of Clinical Endocrinology and Metabolism - April 23, 2024 Category: Endocrinology Authors: Karel Pacak David Taieb Frank I Lin Abhishek Jha Source Type: research
