Combined pituitary hormone deficiency caused by a synonymous HESX1 gene mutation.
CONCLUSIONS: This study of a patient with combined pituitary hormone deficiency revealed an unusual synonymous mutation of the HESX1 gene leading to abnormal RNA processing and underlines the importance of investigating silent variants that at first glance appear to be benign. PMID: 30888394 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 19, 2019 Category: Endocrinology Authors: Coutinho E, Brandão CM, Lemos MC Tags: J Clin Endocrinol Metab Source Type: research

Morning circadian misalignment is associated with insulin resistance in girls with obesity & Polycystic Ovarian Syndrome.
CONCLUSIONS: Circadian misalignment in girls with PCOS is characterized by later melatonin offset relative to both clock time and sleep timing. Findings indicate that morning circadian misalignment associates with metabolic dysregulation in girls with PCOS and obesity. Clinical care of girls with PCOS and obesity would benefit from assessment of sleep and circadian health. Further research is needed to understand mechanisms underlying the relationship between morning circadian misalignment and SI in this population. PMID: 30888398 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 19, 2019 Category: Endocrinology Authors: Simon SL, McWhirter L, Behn CD, Bubar KM, Kaar JL, Pyle L, Rahat H, Garcia-Reyes Y, Carreau AM, Wright KP, Nadeau KJ, Cree-Green M Tags: J Clin Endocrinol Metab Source Type: research

Defective Regulatory B Cells Are Associated with Thyroid Associated Ophthalmopathy.
CONCLUSIONS: We found that regulatory B cells in TAO patients are functionally defective, suggesting the defective Bregs might be responsible for the pathogenesis of TAO. PMID: 30888403 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 19, 2019 Category: Endocrinology Authors: Chen G, Ding Y, Li Q, Li Y, Wen X, Ji X, Bi S, Chen J, Xu J, Chen R, Ye H, Wei L, Yang H Tags: J Clin Endocrinol Metab Source Type: research

Immune Profiling of Thyroid Carcinomas Suggests the Existence of Two Major Phenotypes: an ATC-like and a PDTC-like.
CONCLUSIONS: These data indicated the existence of two major immune phenotypes in thyroid carcinoma: an ATC-like one, including hot and altered-immunosuppressed tumors and a PDTC-like one, including altered-excluded and cold tumors. Confirmation of the findings in locally advanced or metastatic cancer tissues is expected to have important immunotherapeutic implications. PMID: 30882858 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 18, 2019 Category: Endocrinology Authors: Giannini R, Moretti S, Ugolini C, Macerola E, Menicali E, Nucci N, Morelli S, Colella R, Mandarano M, Sidoni A, Panfili M, Basolo F, Puxeddu E Tags: J Clin Endocrinol Metab Source Type: research

Low Plasma Oxytocin Levels and Increased Psychopathology in Hypopituitary Men with Diabetes Insipidus.
CONCLUSIONS: We demonstrate low plasma OT levels and increased psychopathology in hypopituitary men with CDI, suggestive of a possible OT-deficient state. Larger studies in both genders are required to build on these findings and clinically characterize hypopituitary patients with OT deficiency. PMID: 30882859 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 18, 2019 Category: Endocrinology Authors: Aulinas A, Plessow F, Asanza E, Silva L, Marengi DA, Fan W, Abedi P, Verbalis J, Tritos NA, Nachtigall L, Faje AT, Miller KK, Lawson EA Tags: J Clin Endocrinol Metab Source Type: research

Impact of pubertal maturation and chronologic age on sex steroids in peripubertal girls.
Abstract CONTEXT: There is a 4-5 year variation in age of breast maturation in girls. OBJECTIVE: Examine longitudinal changes in sex hormone values, relative to chronologic age and time relative to breast maturation. SETTING AND DESIGN: Longitudinal observational study. Girls were recruited at 6 to 7 years of age and followed every six months. MAIN OUTCOME MEASURES: maturation status; chronologic age; race; fasting blood specimen. Hormones were analyzed selected at six month intervals between two years before and one year after breast maturation, using HPLC tandem mass spectroscopy. RESULTS: Es...
Source: The Journal of Clinical Endocrinology and Metabolism - March 18, 2019 Category: Endocrinology Authors: Biro FM, Huang B, Chandler DW, Fassler CL, Pinney SM Tags: J Clin Endocrinol Metab Source Type: research

Continuous versus bolus infusion of hypertonic saline in the treatment of symptomatic hyponatremia due to SIAD.
Abstract BACKGROUND: Acute hyponatremia is a medical emergency which confers high mortality, attributed primarily to cerebral edema. Expert guidelines advocate the use of intravenous boluses of hypertonic saline, rather than traditional continuous infusion, in order to achieve a faster initial rise in plasma sodium concentration. However, there is a limited evidence base for this recommended policy change. METHODS: We prospectively assessed the clinical and biochemical outcomes in patients treated for symptomatic hyponatremia due to syndrome of inappropriate antidiuresis (SIAD), in response to intravenous bol...
Source: The Journal of Clinical Endocrinology and Metabolism - March 18, 2019 Category: Endocrinology Authors: Garrahy A, Dineen R, Hannon AM, Cuesta M, Tormey W, Sherlock M, Thompson CJ Tags: J Clin Endocrinol Metab Source Type: research

Bile modulates secretion of incretins and insulin: a study on human extrahepatic cholestasis.
CONCLUSIONS: Our findings suggest that acute extrahepatic cholestasis determines a significant impairment in the entero-endocrine gut-pancreatic secretory function. The altered bile flow might determine a direct deleterious effect on beta cell function perhaps mediated by the impairment of incretin hormone function. PMID: 30874733 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 15, 2019 Category: Endocrinology Authors: Mezza T, Moffa S, Ferraro PM, Quero G, Capece U, Carfì A, Cefalo CMA, Cinti F, Sorice GP, Impronta F, Mari A, Pontecorvi A, Alfieri S, Holst JJ, Giaccari A Tags: J Clin Endocrinol Metab Source Type: research

Risk Stratification in Differentiated Thyroid Cancer: From Detection to Final Follow-up.
CONCLUSIONS: Dynamic risk assessment should be used to guide all aspects of thyroid cancer management, beginning before a definitive diagnosis is made and continuing through the final follow-up visit. PMID: 30874735 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 15, 2019 Category: Endocrinology Authors: Tuttle RM, Alzahrani AS Tags: J Clin Endocrinol Metab Source Type: research

Altered thyroid function and structure in overweight and obese children and adolescents: reversal after weight loss.
Abstract CONTEXT: Obesity is associated with hypothyroidism and goiter. OBJECTIVE: The aim of the study was to verify whether thyroid structure and function would improve, after weight loss. DESIGN AND PATIENTS: We evaluated 96 overweight/obese children, who showed an altered parenchymal pattern at thyroid ultrasound without circulating anti-thyroid antibodies. At phase 1, BMI standard deviation score (SDS), body composition, fT4, TSH, high sensitivity C Reactive Protein (CRPhs), white blood cells (WBC), metabolic profile and a thyroid ultrasound were assessed. Thyroid volume was expressed as SDS on the ...
Source: The Journal of Clinical Endocrinology and Metabolism - March 15, 2019 Category: Endocrinology Authors: Licenziati MR, Valerio G, Vetrani I, De Maria G, Liotta F, Radetti G Tags: J Clin Endocrinol Metab Source Type: research

Letter to the Editor: "Familial hypercholesterolemia and increased risk of peripheral artery disease. Is there a role for lipoprotein (a)?"
Letter to the Editor: "Familial hypercholesterolemia and increased risk of peripheral artery disease. Is there a role for lipoprotein (a)?" J Clin Endocrinol Metab. 2019 Mar 14;: Authors: Anagnostis P, Goulis DG PMID: 30869788 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 14, 2019 Category: Endocrinology Authors: Anagnostis P, Goulis DG Tags: J Clin Endocrinol Metab Source Type: research

Isocaloric Fructose Restriction Reduces Serum D-Lactate Concentration in Children With Obesity and Metabolic Syndrome.
Abstract OBJECTIVE: To investigate the link between dietary sugar consumption and two separate pathogenetic mechanisms associated with metabolic syndrome: de novo lipogenesis (DNL) and non-enzymatic glycation. DESIGN AND PARTICIPANTS: We assessed changes in serum D-lactate (the detoxification end-product of methylglyoxal) concentration in response to nine days of isocaloric fructose restriction in 20 children with obesity and metabolic syndrome, and examined correlations with changes in DNL, liver fat, insulin sensitivity and other metrics of hepatic metabolism. INTERVENTIONS: Nine days of dietary sugar ...
Source: The Journal of Clinical Endocrinology and Metabolism - March 14, 2019 Category: Endocrinology Authors: Erkin-Cakmak A, Bains Y, Caccavello R, Noworolski SM, Schwarz JM, Mulligan K, Lustig RH, Gugliucci A Tags: J Clin Endocrinol Metab Source Type: research

High-density Lipoprotein Cholesterol and All-cause and Cause-specific Mortality Among the Elderly.
This study included 7,766 elderly individuals (aged ≥65 years; mean age: 74.4 years) from the Health and Retirement Study. Cox proportional hazards models and Cox models with penalized smoothing splines were used to estimate hazard ratios (HRs) with 95% confidence intervals (CIs) for all-cause and cause-specific mortality. RESULTS: During a median follow-up of 5.9 years, 1,921 deaths occurred. After fully adjustment for covariates, a nonlinear (P for nonlinearity
Source: The Journal of Clinical Endocrinology and Metabolism - March 14, 2019 Category: Endocrinology Authors: Li ZH, Lv YB, Zhong WF, Gao X, Kraus VB, Zou MC, Zhang XR, Li FR, Yuan JQ, Shi XM, Wu XB, Mao C Tags: J Clin Endocrinol Metab Source Type: research

Fibrogenesis Imperfecta Ossium: Clinical Approach to Diagnosis and Management of a Rare Skeletal Disorder.
CONCLUSION: The dearth of information on FIO and low index of suspicion may lead to delayed or missed diagnoses and management. The fundamental skeletal defect appears to be an abnormality in organic matrix of bone characterized by defective mineralization of the abnormal collagen. Research focused on the identification of pathogenetic factors is needed. Albeit, long-term outcomes of growth hormone therapy are yet to be ascertained, short-term effectiveness appears promising. PMID: 30869792 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 14, 2019 Category: Endocrinology Authors: Dhaliwal R, Dhiman V, Rao SD, Bhadada SK Tags: J Clin Endocrinol Metab Source Type: research

Potential Role of Metal Chelation to Prevent the Cardiovascular Complications of Diabetes.
CONCLUSIONS: The purpose of this review is to discuss the potential mechanisms unifying the pathogenesis of atherogenic factors in diabetes with toxic metal exposure, and the potential role of metal chelation. PMID: 30869793 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 14, 2019 Category: Endocrinology Authors: Moreno RC, Navas-Acien A, Escolar E, Nathan DM, Newman J, Schmedtje JF, Diaz D, Lamas GA, Fonseca V Tags: J Clin Endocrinol Metab Source Type: research

Response to Letter to the Editor: "Familial hypercholesterolemia and increased risk of peripheral arterial disease. Is there a role for lipoprotein(a)? ".
Response to Letter to the Editor: "Familial hypercholesterolemia and increased risk of peripheral arterial disease. Is there a role for lipoprotein(a)? ". J Clin Endocrinol Metab. 2019 Mar 14;: Authors: Emanuelsson F, Nordestgaard BG, Benn M PMID: 30869796 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 14, 2019 Category: Endocrinology Authors: Emanuelsson F, Nordestgaard BG, Benn M Tags: J Clin Endocrinol Metab Source Type: research

Pegvisomant improves Glucose Metabolism in Acromegaly: a meta-analysis of prospective interventional studies.
CONCLUSIONS: Independently of disease control, PEG in monotherapy or combined with SSAs seems to improve glucose metabolism, reducing FPG, HbA1c, FPI and HOMA-I. PMID: 30869797 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 14, 2019 Category: Endocrinology Authors: Feola T, Cozzolino A, Simonelli I, Sbardella E, Pozza C, Giannetta E, Gianfrilli D, Pasqualetti P, Lenzi A, Isidori AM Tags: J Clin Endocrinol Metab Source Type: research

Impaired Glucose Metabolism in Primary Aldosteronism is Associated With Cortisol Co-Secretion.
Abstract CONTEXT: Primary aldosteronism (PA) is associated with higher cardiovascular morbidity and metabolic risks. Recent studies report glucocorticoid co-secretion as a relevant phenotype of PA, which could contribute to associated risks, including type 2 diabetes mellitus (T2DM). The relationship between autonomous cortisol secretion (ACS) and glucose metabolism in PA has not been investigated. OBJECTIVE: To evaluate the prevalence of impaired glucose homeostasis in PA patients according to cortisol co-secretion. METHODS: We performed oral-glucose-tolerance-tests (OGTT) and complete testing for hyper...
Source: The Journal of Clinical Endocrinology and Metabolism - March 13, 2019 Category: Endocrinology Authors: Gerards J, Heinrich DA, Adolf C, Meisinger C, Rathmann W, Sturm L, Nirschl N, Bidlingmaier M, Beuschlein F, Thorand B, Peters A, Reincke M, Roden M, Quinkler M Tags: J Clin Endocrinol Metab Source Type: research

PTH Modulation by Aldosterone and Angiotensin II is Blunted in Hyperaldosteronism and Rescued by Adrenalectomy.
Abstract CONTEXT: Accumulating evidences suggest a link between adrenocortical zona glomerulosa and parathyroid gland through mechanisms that remain unexplored. OBJECTIVES: To test the hypothesis that in vivo Angiotensin (Ang) II blockade affects parathyroid hormone (PTH) secretion in hypertensive patients and that aldosterone and Ang II directly stimulate PTH secretion ex vivo. DESIGN AND SETTING: We investigated the changes of serum PTH levels induced by oral captopril (50 mg) administration in patients with primary essential hypertension (EH) and with primary aldosteronism (PA) due to bilateral adrena...
Source: The Journal of Clinical Endocrinology and Metabolism - March 13, 2019 Category: Endocrinology Authors: Lenzini L, Prisco S, Vanderriele PE, Lerco S, Torresan F, Maiolino G, Seccia TM, Iacobone M, Rossi GP Tags: J Clin Endocrinol Metab Source Type: research

Combined gestational age- and birth weight-adjusted cutoffs for newborn screening of congenital adrenal hyperplasia.
CONCLUSIONS: The use of cutoff values adjusted for both GA and BW significantly reduces FP rates (0.03%), and increases overall PPV (16.5%). Based on our ten years of experience, we recommend the implementation of this novel, two parameter-adjusted approach for NBS of classical CAH, in NBS programs worldwide. PMID: 30865229 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 13, 2019 Category: Endocrinology Authors: Pode-Shakked N, Blau A, Pode-Shakked B, Tiosano D, Weintrob N, Eyal O, Zung A, Levy-Khademi F, Tenenbaum-Rakover Y, Zangen D, Gillis D, Pinhas-Hamiel O, Loewenthal N, de Vries L, Landau Z, Rachmiel M, Abu-Libdeh A, Eliakim A, Strich D, Koren I, German A, Tags: J Clin Endocrinol Metab Source Type: research

Transoral Vestibular Thyroidectomy: Current State of Affairs and Considerations for the Future.
CONCLUSIONS: TOETVA is a suitable surgical option for a carefully selected patient population with proven safety and feasibility. The potential value of the procedure outside enhanced cosmesis continues to be defined. PMID: 30860578 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 12, 2019 Category: Endocrinology Authors: Russell JO, Razavi CR, Shaear M, Chen LW, Lee AH, Ranganath R, Tufano RP Tags: J Clin Endocrinol Metab Source Type: research

Long Term Efficacy of a Single Session RFA of Benign Thyroid Nodules: A Longitudinal 5-Year Observational Study.
CONCLUSIONS: This study, by demonstrating a durable shrinkage of benign thyroid nodules treated by RFA, as well as an improvement of compressive and visual symptoms, establishes the reliability of RFA as an alternative to surgery in the management of thyroid nodules, thus representing a remarkable therapeutic tool for clinical practice. PMID: 30860579 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 12, 2019 Category: Endocrinology Authors: Deandrea M, Trimboli P, Garino F, Mormile A, Magliona G, Ramunni MJ, Giovanella L, Limone PP Tags: J Clin Endocrinol Metab Source Type: research

Biguanides exert antitumoral actions in pituitary tumor cells through AMPK-dependent and -independent mechanisms.
CONCLUSION: Altogether, our data unveil clear antitumoral effects of biguanides on PitNET cells, opening new avenues to explore their potential as drugs to treat these pathologies. PMID: 30860580 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 12, 2019 Category: Endocrinology Authors: Vázquez-Borrego MC, Fuentes-Fayos AC, Herrera Martínez AD, L-López F, Ibáñez-Costa A, Moreno Moreno P, Alhambra-Expósito MR, Barrera-Martín A, Blanco-Acevedo C, Dios E, Venegas-Moreno E, Solivera J, Gahete MD, Soto-Moreno A, Gálvez-Moreno MA, Cast Tags: J Clin Endocrinol Metab Source Type: research

Response to Letter to the Editor Progesterone is Important for Transwomen's Therapy-applying evidence for the benefits of progesterone in ciswomen.
PMID: 30860583 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 12, 2019 Category: Endocrinology Authors: Prior JC Tags: J Clin Endocrinol Metab Source Type: research

Enteroendocrine connections in congenital isolated GH deficiency due to a GHRH receptor gene mutation.
stro M, Aguiar-Oliveira MH Abstract CONTEXT: GH and IGF-I are crucial for attainment of normal body size and regulation of food intake, nutrients storage, and insulin sensitivity. Enteroendocrine connections exist between the GH/IGF-I axis and insulin, ghrelin, and glucagon-like peptide 1 (GLP-1). The status of these connections in GH deficiency (GHD) is unknown. OBJECTIVE: To study the enteroendocrine connections before and after a standard meal test in a homogeneous population of adults with congenital untreated isolated GHD (IGHD) due to a mutation in the GHRH receptor gene. DESIGN: In a cross-section...
Source: The Journal of Clinical Endocrinology and Metabolism - March 12, 2019 Category: Endocrinology Authors: Oliveira-Santos AA, Salvatori R, Nogueira MC, Bueno AC, Barros-Oliveira CS, Leal ÂCGB, Marinho CG, Damascena NP, Oliveira DA, Melo MA, Oliveira CRP, da Costa FO, Dos Santos JSS, Santos PFC, Campos VC, Santos EG, Melo EV, Barbosa MLA, Rocha IES, de Castro Tags: J Clin Endocrinol Metab Source Type: research

CORRIGENDUM FOR "Pilot Dose Comparison of Apatinib in Chinese Patients with Progressive Radioiodine-Refractory Differentiated Thyroid Cancer".
CORRIGENDUM FOR "Pilot Dose Comparison of Apatinib in Chinese Patients with Progressive Radioiodine-Refractory Differentiated Thyroid Cancer". J Clin Endocrinol Metab. 2019 Mar 12;: Authors: PMID: 30860587 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 12, 2019 Category: Endocrinology Tags: J Clin Endocrinol Metab Source Type: research

Effect of Parathyroidectomy on cardiovascular risk factors in primary hyperparathyroidism: A randomised clinical trial.
CONCLUSION: PTX may decrease risk of cardiovascular diseases in PHPT by lowering total cholesterol levels, although ambulatory diastolic BP increases in response to surgery. Patients with moderate-to-severe hypercalcemia may benefit from PTX by a decrease in PWV. PMID: 30860588 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 12, 2019 Category: Endocrinology Authors: Ejlsmark-Svensson H, Rolighed L, Rejnmark L Tags: J Clin Endocrinol Metab Source Type: research

Letter to the Editor: "Progesterone is Important for Transwomen's Therapy-applying evidence for the benefits of progesterone in ciswomen".
Letter to the Editor: "Progesterone is Important for Transwomen's Therapy-applying evidence for the benefits of progesterone in ciswomen". J Clin Endocrinol Metab. 2019 Mar 12;: Authors: Iwamoto SJ, T'Sjoen G, Safer JD, Davidge-Pitts CJ, Wierman ME, Glodowski MB, Rothman MS PMID: 30860591 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 12, 2019 Category: Endocrinology Authors: Iwamoto SJ, T'Sjoen G, Safer JD, Davidge-Pitts CJ, Wierman ME, Glodowski MB, Rothman MS Tags: J Clin Endocrinol Metab Source Type: research

Phenotypic features and response to growth hormone treatment of patients with a molecular defect of the IGF-1 receptor.
CONCLUSION: A clinical score encompassing birth weight and/or length, short stature, microcephaly and IGF-1 is useful for selecting patients for IGF1R analysis. Feeding problems are common and the growth response to GH treatment is moderate. PMID: 30848790 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 8, 2019 Category: Endocrinology Authors: Walenkamp MJE, Robers JML, Wit JM, Zandwijken GRJ, van Duyvenvoorde HA, Oostdijk W, Hokken-Koelega ACS, Kant SG, Losekoot M Tags: J Clin Endocrinol Metab Source Type: research

Separate and Combined Effects of GIP and GLP-1 Infusions on Bone Metabolism in Overweight Men without Diabetes.
T, Knop FK Abstract CONTEXT: The gut-derived incretin hormones, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1), have been suggested to play a role in bone metabolism. Exogenous administration of GIP inhibits bone resorption, while the effect of GLP-1 is less clear. Furthermore, the combined effect of exogenous GIP and GLP-1 on bone metabolism is unknown. OBJECTIVE: To investigate the effect of separate and combined infusions of the incretin hormones GIP and GLP-1 on bone resorption and formation. DESIGN: Randomized, double-blinded, placebo-controlled, crossover st...
Source: The Journal of Clinical Endocrinology and Metabolism - March 8, 2019 Category: Endocrinology Authors: Bergmann NC, Lund A, Gasbjerg LS, Jørgensen NR, Jessen L, Hartmann B, Holst JJ, Christensen MB, Vilsbøll T, Knop FK Tags: J Clin Endocrinol Metab Source Type: research

Skeletal Fragility & Its Clinical Determinants In Children With Type 1 Diabetes.
Skeletal Fragility & Its Clinical Determinants In Children With Type 1 Diabetes. J Clin Endocrinol Metab. 2019 Mar 08;: Authors: Chen SC, Shepherd S, McMillan M, McNeilly J, Foster J, Wong SC, Robertson KJ, Ahmed SF Abstract CONTEXT: Type 1 diabetes (T1D) is associated with an increased fracture risk at all ages. OBJECTIVE: To understand the determinants of bone health and fractures in children with T1D. DESIGN: Case-control study of children with T1D on bone turnover markers, DXA and 3T-MRI of the proximal tibia to assess bone microarchitecture and vertebral marrow adiposity, compared t...
Source: The Journal of Clinical Endocrinology and Metabolism - March 8, 2019 Category: Endocrinology Authors: Chen SC, Shepherd S, McMillan M, McNeilly J, Foster J, Wong SC, Robertson KJ, Ahmed SF Tags: J Clin Endocrinol Metab Source Type: research

Individuals with prediabetes display different age-related pathophysiological characteristics.
CONCLUSIONS: Subjects with IFG or IGT exhibit different age-related pathophysiologic characteristics. A more precise phenotyping of subjects with IGT or IFG could help to better design individualized preventive approaches to counteract diabetes progression. PMID: 30848793 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 8, 2019 Category: Endocrinology Authors: Fiorentino TV, Pedace E, Succurro E, Andreozzi F, Perticone M, Sciacqua A, Perticone F, Sesti G Tags: J Clin Endocrinol Metab Source Type: research

Letter to the Editor: [Association Between Cortical Bone Microstructure and Statin Use in Older Women].
PMID: 30848797 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 8, 2019 Category: Endocrinology Authors: Al-Khazaali A, Situala S, Dhindsa S Tags: J Clin Endocrinol Metab Source Type: research

ERRATUM FOR "PTHrP-Mediated Hypercalcemia: Causes and Survival in 138 Patients".
ERRATUM FOR "PTHrP-Mediated Hypercalcemia: Causes and Survival in 138 Patients". J Clin Endocrinol Metab. 2019 Mar 08;: Authors: PMID: 30848799 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 8, 2019 Category: Endocrinology Tags: J Clin Endocrinol Metab Source Type: research

New Concepts About Familial Isolated Hyperparathyroidism.
CONCLUSIONS: The current concept of FIHP led to a focus on small kindreds without mutation of MEN1, CASR, or CDC73. These assisted in the identification of germline activating GCM2 mutations in 17%. There is a need for clinical and mutational characterization in more cases to determine any unique clinical features of FIHP, either with or without mutation of GCM2. PMID: 30848815 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 8, 2019 Category: Endocrinology Authors: Marx SJ Tags: J Clin Endocrinol Metab Source Type: research

CORRIGENDUM for "Aldosterone LC-MS/MS Assay-Specific Threshold Values in Screening and Confirmatory Testing for Primary Aldosteronism".
CORRIGENDUM for "Aldosterone LC-MS/MS Assay-Specific Threshold Values in Screening and Confirmatory Testing for Primary Aldosteronism". J Clin Endocrinol Metab. 2019 Mar 08;: Authors: PMID: 30848822 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 8, 2019 Category: Endocrinology Tags: J Clin Endocrinol Metab Source Type: research

Dopamine Agonist-Induced Impulse Control Disorders in Patients With Prolactinoma: A Cross-Sectional Multicenter Study.
Abstract CONTEXT: Dopamine agonist (DA)-induced impulse control disorder (ICD) in prolactinomas is not sufficiently known. OBJECTIVE: To evaluate the prevalence of DA-induced ICDs and possible risk factors related to these disorders in patients with prolactinoma. DESIGN, SETTING AND PARTICIPANTS: This is a cross-sectional multicenter study involving 308 prolactinoma patients followed-up in tertiary referral centers who received at least 3 months of DA therapy. DA-induced ICDs (pathological gambling, hypersexuality, compulsive shopping and compulsive eating) and impulsivity were assessed using the Questio...
Source: The Journal of Clinical Endocrinology and Metabolism - March 8, 2019 Category: Endocrinology Authors: Dogansen SC, Cikrikcili U, Oruk G, Kutbay NO, Tanrikulu S, Hekimsoy Z, Hadzalic A, Gorar S, Omma T, Mert M, Akbaba G, Yalin GY, Bayram F, Ozkan M, Yarman S Tags: J Clin Endocrinol Metab Source Type: research

CORRIGENDUM FOR "Application of Mindfulness in a Tier 3 Obesity Service Improves Eating Behavior and Facilitates Successful Weight Loss".
CORRIGENDUM FOR "Application of Mindfulness in a Tier 3 Obesity Service Improves Eating Behavior and Facilitates Successful Weight Loss". J Clin Endocrinol Metab. 2019 Mar 08;: Authors: PMID: 30848826 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 8, 2019 Category: Endocrinology Tags: J Clin Endocrinol Metab Source Type: research

Plasma Fibroblast Growth Factor 21 is Associated with Severity of Nonalcoholic Steatohepatitis in Patients with Obesity and Type 2 Diabetes.
Abstract CONTEXT: The relationship between plasma FGF21, insulin resistance and steatohepatitis has not been systematically assessed. OBJECTIVE: To determine if higher plasma FGF21 is associated with worse steatohepatitis on liver biopsy in patients with NAFLD. DESIGN AND SETTING: Cross-sectional study in a University Hospital.Patients Interventions and Main Outcome MeasuresPatients with BMI>25 (n=187) underwent: (a) euglycemic hyperinsulinemic clamp to assess tissue specific insulin resistance; (b) liver magnetic resonance spectroscopy (1H-MRS) for intrahepatic triglyceride (IHTG) quantification, (c)...
Source: The Journal of Clinical Endocrinology and Metabolism - March 8, 2019 Category: Endocrinology Authors: Barb D, Bril F, Kalavalapalli S, Cusi K Tags: J Clin Endocrinol Metab Source Type: research

Response to Letter: Association between cortical bone microstructure and statin use in older women.
n M PMID: 30848828 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 8, 2019 Category: Endocrinology Authors: Larsson BAM, Sundh D, Mellström D, Axelsson KF, Nilsson AG, Lorentzon M Tags: J Clin Endocrinol Metab Source Type: research

Distinctive Reproductive Phenotypes in Peripubertal Girls at Risk for Polycystic Ovary Syndrome.
Abstract CONTEXT: Increased testosterone (T) levels are a cardinal feature of PCOS. Female relatives of affected women, including postmenopausal mothers and premenarchal daughters (PCOS-d), have elevated T levels consistent with a genetic susceptibility to this phenotype. Obese girls (OB-g) also have increased T levels throughout puberty, which may indicate risk for PCOS. OBJECTIVE: We tested the hypothesis that premenarchal PCOS-d have distinctive phenotypic features compared to OB-g. DESIGN, SETTING, AND PARTICIPANTS: 48 PCOS-d, 30 OB-g and 22 normal weight (NW-g) premenarchal girls were studied. Mothe...
Source: The Journal of Clinical Endocrinology and Metabolism - March 7, 2019 Category: Endocrinology Authors: Torchen LC, Legro RS, Dunaif A Tags: J Clin Endocrinol Metab Source Type: research

ERRATUM FOR "Clinical, Biochemical, and Genetic Characteristics of "Nonclassic" Apparent Mineralocorticoid Excess Syndrome".
ERRATUM FOR "Clinical, Biochemical, and Genetic Characteristics of "Nonclassic" Apparent Mineralocorticoid Excess Syndrome". J Clin Endocrinol Metab. 2019 Mar 07;: Authors: PMID: 30844046 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 7, 2019 Category: Endocrinology Tags: J Clin Endocrinol Metab Source Type: research

Augmented GLP-1 secretion as seen after gastric bypass may be obtained by delaying carbohydrate digestion.
CONCLUSIONS: GLP-1 secretion depends on the rate of carbohydrate digestion, but in a different manner after RYGB. Enhanced GLP-1 secretion is central after RYGB, but it may also be obtained in unoperated individuals by delaying hydrolysis of carbohydrates, pushing their digestion and absorption distally in the small intestine. PMID: 30844053 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 7, 2019 Category: Endocrinology Authors: Martinussen C, Bojsen-Møller KN, Dirksen C, Svane MS, Kristiansen VB, Hartmann B, Holst JJ, Madsbad S Tags: J Clin Endocrinol Metab Source Type: research

Impact of USP8 gene mutations on protein deregulation in Cushing's disease.
CONCLUSIONS: We could demonstrate that USP8 mutations are associated with deregulation of p27/kip1, HSP90, and phosphorylated CREB. These findings suggest that these proteins are direct or indirect clients of USP8 and could therefore be potential targets for therapeutic approaches in patients with CD. PMID: 30844069 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 7, 2019 Category: Endocrinology Authors: Weigand I, Knobloch L, Flitsch J, Saeger W, Monoranu CM, Höfner K, Herterich S, Rotermund R, Ronchi CL, Buchfelder M, Glatzel M, Hagel C, Fassnacht M, Deutschbein T, Sbiera S Tags: J Clin Endocrinol Metab Source Type: research

Long-term outcome of primary bilateral macronodular adrenocortical hyperplasia after unilateral adrenalectomy.
CONCLUSIONS: Our data suggest that unilateral adrenalectomy of PBMAH patients leads to clinical remission and a lower incidence of adrenal crisis, but less sufficient biochemical control of hypercortisolism potentially provoking a higher mortality. PMID: 30844071 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 7, 2019 Category: Endocrinology Authors: Oßwald A, Quinkler M, Di Dalmazi G, Deutschbein T, Rubinstein G, Ritzel K, Zopp S, Bertherat J, Beuschlein F, Reincke M Tags: J Clin Endocrinol Metab Source Type: research

Continuous Glucose Monitoring Predicts Progression to Diabetes in Autoantibody Positive Children.
CONCLUSIONS: In conclusion,>18% CGM time spent above 140 mg/dl predicts progression to diabetes in islet Ab+ children. PMID: 30844073 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 7, 2019 Category: Endocrinology Authors: Steck AK, Dong F, Taki I, Hoffman M, Simmons K, Frohnert BI, Rewers MJ Tags: J Clin Endocrinol Metab Source Type: research

Why do normal children have acromegalic levels of IGF-I during puberty?
CONCLUSION: We suggest that serum levels of IGF-I should be watched in children with poor development of sexual organs, although it remains to be investigated whether GH in some cases should be added to sex steroids in management of hypogonadism in pubertal children, e.g. in boys with micro-penis. PMID: 30840065 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 6, 2019 Category: Endocrinology Authors: Juul A, Skakkebæk NE Tags: J Clin Endocrinol Metab Source Type: research

SGLT2 Inhibitors Increase the Risk of Diabetic Ketoacidosis Developing in the Community and During Hospital Admission.
Abstract CONTEXT: Diabetic ketoacidosis (DKA) has been associated with the use of sodium glucose cotransporter 2 inhibitors (SGLT2i). OBJECTIVE: To determine the incidence, characteristics and outcomes of DKA in SGLT2i-users vs non-users with type 2 diabetes. DESIGN: Retrospective, multi-center, controlled cohort study. SETTING: All public hospitals in Melbourne and Geelong (combined population 5 million), Australia, from 1 September 2015 - 31 October 2017. PATIENTS: Consecutive cases of DKA that developed in the community, or during the course of hospital admission, in patients with type 2 dia...
Source: The Journal of Clinical Endocrinology and Metabolism - March 5, 2019 Category: Endocrinology Authors: Hamblin PS, Wong R, Ekinci EI, Fourlanos S, Shah S, Jones AR, Hare MJL, Calder GL, Epa DS, George EM, Giri R, Kotowicz MA, Kyi M, Lafontaine N, MacIsaac RJ, Nolan BJ, O'Neal DN, Renouf D, Varadarajan S, Wong J, Xu S, Bach LA Tags: J Clin Endocrinol Metab Source Type: research

Extracellular fluid volume expansion uncovers a natriuretic action of GLP-1: a functional GLP-1-renal axis in man.
CONCLUSIONS: In volume loaded subjects, GLP-1 induces significant natriuresis, likely brought about via a tubular mechanism secondary to suppression of ANG II, independent of renal hemodynamics, supporting the existence of a GLP-1-renal axis. PMID: 30835273 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 5, 2019 Category: Endocrinology Authors: Asmar A, Cramon PK, Simonsen L, Asmar M, Sorensen CM, Madsbad S, Moro C, Hartmann B, Jensen BL, Holst JJ, Bülow J Tags: J Clin Endocrinol Metab Source Type: research

High density lipoprotein function is reduced in patients affected by genetic or idiopathic hypogonadism.
CONCLUSION(S): In hypogonadal patients pro-atherogenic lipoprotein-associated changes are associated with lower cholesterol efflux and increased influx, thus offering an explanation for a potentially increased CV risk. PMID: 30835274 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 5, 2019 Category: Endocrinology Authors: Adorni MP, Zimetti F, Cangiano B, Vezzoli V, Bernini F, Caruso D, Corsini A, Sirtori CR, Cariboni A, Bonomi M, Ruscica M Tags: J Clin Endocrinol Metab Source Type: research