Letter to the Editor from Asa and Mete: "Hypophysitis, the Growing Spectrum of a Rare Pituitary Disease"
J Clin Endocrinol Metab. 2022 Jan 17:dgac025. doi: 10.1210/clinem/dgac025. Online ahead of print.NO ABSTRACTPMID:35037041 | DOI:10.1210/clinem/dgac025 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - January 17, 2022 Category: Endocrinology Authors: Sylvia L Asa Ozgur Mete Source Type: research

Response to Letter to the editor from Asa and Mete: "Hypophysitis, the Growing Spectrum of a Rare Pituitary Disease"
J Clin Endocrinol Metab. 2022 Jan 17:dgac026. doi: 10.1210/clinem/dgac026. Online ahead of print.NO ABSTRACTPMID:35037055 | DOI:10.1210/clinem/dgac026 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - January 17, 2022 Category: Endocrinology Authors: Fabienne Langlois Elena V Varlamov Maria Fleseriu Source Type: research

Circulating levels of microRNA-122 and hepatic fat change in response to weight-loss interventions: CENTRAL Trial
J Clin Endocrinol Metab. 2022 Jan 17:dgac023. doi: 10.1210/clinem/dgac023. Online ahead of print.ABSTRACTPURPOSE: Little is known about the relations between changes in circulating microRNA-122 (miR-122) and liver fat in response to weight-loss interventions. We aimed to investigate the association between miR-122 and changes of hepatic fat content during 18-month diet and physical activity interventions.METHODS: The CENTRAL trial is an 18-month randomized, controlled trial among adults with abdominal obesity or dyslipidemia. Subjects were randomly assigned to a low-fat diet or a Mediterranean/low-carbohydrate diet. After ...
Source: The Journal of Clinical Endocrinology and Metabolism - January 17, 2022 Category: Endocrinology Authors: Mengying Wang Qiaochu Xue Xiang Li Knut Krohn Stefanie Ziesche Uta Ceglarek Matthias Bl üher Maria Keller Anat Yaskolka Meir Yoriko Heianza Peter Kovacs Iris Shai Lu Qi Source Type: research

Surveillance improves outcomes for carriers of SDHB pathogenic variants: a multi-center study
CONCLUSION: SDHB carriers with s-d tumors had smaller tumors, reduced risk of metastatic disease and lower mortality compared to probands. Our results suggest that SDHB PV carriers should undertake surveillance to improve clinical outcomes.PMID:35037935 | DOI:10.1210/clinem/dgac019 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - January 17, 2022 Category: Endocrinology Authors: Dahlia F Davidoff Diana E Benn Michael Field Ashley Crook Bruce G Robinson Katherine Tucker Richard De Abreu Lourenco John R Burgess Roderick J Clifton-Bligh Source Type: research

Effects of Different Doses of Exercise on Inflammation Markers Among Adolescents with Overweight/Obese: HEPAFIT Study
J Clin Endocrinol Metab. 2022 Jan 17:dgac021. doi: 10.1210/clinem/dgac021. Online ahead of print.ABSTRACTPROPOSE: Obesity-related metabolic risk factors in adolescents with overweight/obesity may be associated with systemic low-grade inflammation, and therefore we investigated whether a 6-month exercise training altered markers of inflammation.METHODS: Secondary analyses of a randomized controlled exercise-based intervention trial (September 2017 to December 2018). Adolescents aged 11 to 17 years (Tanner stage II to V), 70% girls, with a body mass index (BMI) z-score at or above the 85 th percentile, and/or with excess of ...
Source: The Journal of Clinical Endocrinology and Metabolism - January 17, 2022 Category: Endocrinology Authors: Robinson Ram írez-Vélez Antonio Garc ía-Hermoso Mar ía Correa-Rodríguez Joaqu ín Fernández-Irigoyen Sara Palomino-Echeverr ía Enrique Santamar ía Jorge Enrique Correa-Bautista Katherine Gonz ález-Ruíz Mikel Izquierdo Source Type: research

Steroid hormone profiles and molecular diagnostic tools in pediatric patients with non-CAH primary adrenal insufficiency
J Clin Endocrinol Metab. 2022 Jan 13:dgac016. doi: 10.1210/clinem/dgac016. Online ahead of print.ABSTRACTBACKGROUND: There is a significant challenge of attributing specific diagnoses to patients with primary adrenal insufficiency of unknown etiology other than congenital adrenal hyperplasia (non-CAH PAI). Specific diagnoses per se may guide personalized treatment or may illuminate pathophysiology.OBJECTIVE: Investigation of the efficacy of steroid hormone profiles and high-throughput sequencing methods in establishing the etiology in non-CAH PAI of unknown origin.DESIGN: Paediatric patients with non-CAH PAI whose etiology...
Source: The Journal of Clinical Endocrinology and Metabolism - January 14, 2022 Category: Endocrinology Authors: Tuba Seven Menevse Yasemin Kendir Demirkol Busra Gurpinar Tosun Elvan Bayramoglu Melek Yildiz Sezer Acar Seda Erisen Karaca Zerrin Orbak Asan Onder Elif Sobu Ahmet An ık Zeynep Atay Fuat Bugrul Ayse Derya Bulus Korcan Demir Durmus Dogan Hamdi Cihan Emeks Source Type: research

Efficacy of ethanol ablation in long-term local control of neck nodal metastases in adult papillary thyroid carcinoma
J Clin Endocrinol Metab. 2022 Jan 14:dgac018. doi: 10.1210/clinem/dgac018. Online ahead of print.NO ABSTRACTPMID:35030635 | DOI:10.1210/clinem/dgac018 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - January 14, 2022 Category: Endocrinology Authors: Ian D Hay Robert A Lee J William Charboneau Source Type: research

Steroid hormone profiles and molecular diagnostic tools in pediatric patients with non-CAH primary adrenal insufficiency
J Clin Endocrinol Metab. 2022 Jan 13:dgac016. doi: 10.1210/clinem/dgac016. Online ahead of print.ABSTRACTBACKGROUND: There is a significant challenge of attributing specific diagnoses to patients with primary adrenal insufficiency of unknown etiology other than congenital adrenal hyperplasia (non-CAH PAI). Specific diagnoses per se may guide personalized treatment or may illuminate pathophysiology.OBJECTIVE: Investigation of the efficacy of steroid hormone profiles and high-throughput sequencing methods in establishing the etiology in non-CAH PAI of unknown origin.DESIGN: Paediatric patients with non-CAH PAI whose etiology...
Source: The Journal of Clinical Endocrinology and Metabolism - January 14, 2022 Category: Endocrinology Authors: Tuba Seven Menevse Yasemin Kendir Demirkol Busra Gurpinar Tosun Elvan Bayramoglu Melek Yildiz Sezer Acar Seda Erisen Karaca Zerrin Orbak Asan Onder Elif Sobu Ahmet An ık Zeynep Atay Fuat Bugrul Ayse Derya Bulus Korcan Demir Durmus Dogan Hamdi Cihan Emeks Source Type: research

Efficacy of ethanol ablation in long-term local control of neck nodal metastases in adult papillary thyroid carcinoma
J Clin Endocrinol Metab. 2022 Jan 14:dgac018. doi: 10.1210/clinem/dgac018. Online ahead of print.NO ABSTRACTPMID:35030635 | DOI:10.1210/clinem/dgac018 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - January 14, 2022 Category: Endocrinology Authors: Ian D Hay Robert A Lee J William Charboneau Source Type: research

Steroid hormone profiles and molecular diagnostic tools in pediatric patients with non-CAH primary adrenal insufficiency
J Clin Endocrinol Metab. 2022 Jan 13:dgac016. doi: 10.1210/clinem/dgac016. Online ahead of print.ABSTRACTBACKGROUND: There is a significant challenge of attributing specific diagnoses to patients with primary adrenal insufficiency of unknown etiology other than congenital adrenal hyperplasia (non-CAH PAI). Specific diagnoses per se may guide personalized treatment or may illuminate pathophysiology.OBJECTIVE: Investigation of the efficacy of steroid hormone profiles and high-throughput sequencing methods in establishing the etiology in non-CAH PAI of unknown origin.DESIGN: Paediatric patients with non-CAH PAI whose etiology...
Source: The Journal of Clinical Endocrinology and Metabolism - January 14, 2022 Category: Endocrinology Authors: Tuba Seven Menevse Yasemin Kendir Demirkol Busra Gurpinar Tosun Elvan Bayramoglu Melek Yildiz Sezer Acar Seda Erisen Karaca Zerrin Orbak Asan Onder Elif Sobu Ahmet An ık Zeynep Atay Fuat Bugrul Ayse Derya Bulus Korcan Demir Durmus Dogan Hamdi Cihan Emeks Source Type: research

Intra-trial mean 25(OH)D and PTH levels and risk of falling in older men and women in the Boston STOP IT trial
CONCLUSIONS: The findings highlight the importance of maintaining the circulating 25(OH)D level between 20 and 40 ng/ml, the range that is also recommended for bone health. At PTH levels within the normal range, there was no detectible independent association of PTH with fall risk.PMID:35022738 | DOI:10.1210/clinem/dgac012 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - January 13, 2022 Category: Endocrinology Authors: Bess Dawson-Hughes Jifan Wang Kathryn Barger Heike A Bischoff-Ferrari Christopher T Sempos Ramon A Durazo-Arvizu Lisa Ceglia Source Type: research

Hyperthyroidism in Graves' disease causes sleep disorders related to sympathetic hypertonia
CONCLUSIONS: Hyperthyroidism caused by GD augmented ST and exacerbated subjective SD. Normalization of hyperthyroidism caused by GD improved subjective SD.PMID:35022743 | DOI:10.1210/clinem/dgac013 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - January 13, 2022 Category: Endocrinology Authors: Kazuhisa Matsumoto Shoichiro Izawa Kenji Fukaya Eriko Matsuda Misato Fujiyama Kazuhiko Matsuzawa Tsuyoshi Okura Masahiko Kato Shin-Ichi Taniguchi Kazuhiro Yamamoto Source Type: research

Circulating MicroRNA Profiles as Potential Biomarkers for differentiated thyroid cancer recurrence
CONCLUSIONS: The present study does not provide evidence that known miRNAs can be used as circulating markers for recurrence of thyroid cancer. However, we suggest that novel miRNA molecules may be related to thyroid cancer pathogenesis.PMID:35022762 | DOI:10.1210/clinem/dgac009 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - January 13, 2022 Category: Endocrinology Authors: Jelena Jankovic Miljus Mar ía Augusta Guillén-Sacoto Jennifer Makiadi-Alvarado Le ón Wert-Lamas Julia Ramirez-Moya Mercedes Robledo Pilar Santisteban Garcilaso Riesco-Eizaguirre Source Type: research

Salt sensitivity of blood pressure and aldosterone: interaction between Lysine-specific demethylase 1 gene, sex, and age
CONCLUSIONS: SSBP associated with LSD1 risk allele status is driven by women of deplete estrogen state. Mechanisms related to a resistance to develop SSBP in females are uncertain but may relate to an estrogen modulating effect on mineralocorticoid receptor activation and/or LSD1 epigenetic regulation of the mineralocorticoid receptor.PMID:35022775 | DOI:10.1210/clinem/dgac011 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - January 13, 2022 Category: Endocrinology Authors: Wasita W Parksook Mahyar Heydarpour Shadi K Gholami James M Luther Paul N Hopkins Luminita H Pojoga Jonathan S Williams Source Type: research

Variability, mean, and baseline values of metabolic parameters in predicting the risk of type 2 diabetes
CONCLUSION: The post-load PGs, past alteration of measurements, and mutual interactions among indices of MPs are important risk factors for T2DM development.PMID:35026007 | DOI:10.1210/clinem/dgac017 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - January 13, 2022 Category: Endocrinology Authors: Duong Duc Pham Jaekyung Song Yunwan Jeon Ibrahimi Hajar Chae Hun Leem Source Type: research

Eradicating Racism: An Endocrine Society Policy Perspective
J Clin Endocrinol Metab. 2022 Jan 13:dgab896. doi: 10.1210/clinem/dgab896. Online ahead of print.ABSTRACTThe Endocrine Society recognizes racism as a root cause of the health disparities that affect racial/ethnic minority communities in the United States and throughout the world. In this policy perspective, we review the sources and impact of racism on endocrine health disparities and propose interventions aimed at promoting an equitable, diverse, and just healthcare system. Racism in the healthcare system perpetuates health disparities through unequal access and quality of health services, inadequate representation of hea...
Source: The Journal of Clinical Endocrinology and Metabolism - January 13, 2022 Category: Endocrinology Authors: Ruban Dhaliwal Rocio I Pereira Alicia M Diaz-Thomas Camille E Powe Licy L Yanes Cardozo Joshua J Joseph Source Type: research

Universal Germline Panel Testing for Individuals with Pheochromocytoma and Paraganglioma Produces High Diagnostic Yield
CONCLUSION: Our data demonstrate a high diagnostic yield in individuals with and without established risk factors, a low inconclusive result rate, and a substantial contribution to diagnostic yield from rare genes. These findings support universal testing of all individuals with PPGL and the use of concurrent MGPT as the ideal platform.PMID:35026032 | DOI:10.1210/clinem/dgac014 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - January 13, 2022 Category: Endocrinology Authors: Carolyn Horton Holly LaDuca Ashley Deckman Kate Durda Michelle Jackson Marcy Richardson Yuan Tian Amal Yussuf Kory Jasperson Tobias Else Source Type: research

Intra-trial mean 25(OH)D and PTH levels and risk of falling in older men and women in the Boston STOP IT trial
CONCLUSIONS: The findings highlight the importance of maintaining the circulating 25(OH)D level between 20 and 40 ng/ml, the range that is also recommended for bone health. At PTH levels within the normal range, there was no detectible independent association of PTH with fall risk.PMID:35022738 | DOI:10.1210/clinem/dgac012 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - January 13, 2022 Category: Endocrinology Authors: Bess Dawson-Hughes Jifan Wang Kathryn Barger Heike A Bischoff-Ferrari Christopher T Sempos Ramon A Durazo-Arvizu Lisa Ceglia Source Type: research

Hyperthyroidism in Graves' disease causes sleep disorders related to sympathetic hypertonia
CONCLUSIONS: Hyperthyroidism caused by GD augmented ST and exacerbated subjective SD. Normalization of hyperthyroidism caused by GD improved subjective SD.PMID:35022743 | DOI:10.1210/clinem/dgac013 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - January 13, 2022 Category: Endocrinology Authors: Kazuhisa Matsumoto Shoichiro Izawa Kenji Fukaya Eriko Matsuda Misato Fujiyama Kazuhiko Matsuzawa Tsuyoshi Okura Masahiko Kato Shin-Ichi Taniguchi Kazuhiro Yamamoto Source Type: research

Circulating MicroRNA Profiles as Potential Biomarkers for differentiated thyroid cancer recurrence
CONCLUSIONS: The present study does not provide evidence that known miRNAs can be used as circulating markers for recurrence of thyroid cancer. However, we suggest that novel miRNA molecules may be related to thyroid cancer pathogenesis.PMID:35022762 | DOI:10.1210/clinem/dgac009 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - January 13, 2022 Category: Endocrinology Authors: Jelena Jankovic Miljus Mar ía Augusta Guillén-Sacoto Jennifer Makiadi-Alvarado Le ón Wert-Lamas Julia Ramirez-Moya Mercedes Robledo Pilar Santisteban Garcilaso Riesco-Eizaguirre Source Type: research

Salt sensitivity of blood pressure and aldosterone: interaction between Lysine-specific demethylase 1 gene, sex, and age
CONCLUSIONS: SSBP associated with LSD1 risk allele status is driven by women of deplete estrogen state. Mechanisms related to a resistance to develop SSBP in females are uncertain but may relate to an estrogen modulating effect on mineralocorticoid receptor activation and/or LSD1 epigenetic regulation of the mineralocorticoid receptor.PMID:35022775 | DOI:10.1210/clinem/dgac011 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - January 13, 2022 Category: Endocrinology Authors: Wasita W Parksook Mahyar Heydarpour Shadi K Gholami James M Luther Paul N Hopkins Luminita H Pojoga Jonathan S Williams Source Type: research

WFS1 gene associated diabetes phenotypes and identification of a founder mutation in Southern India
CONCLUSION: These results project the need for NGS-based parallel multigene testing as a tool for early diagnosis of WFS and identify heterozygous WFS1 variants implicated in young onset diabetes.PMID:35018440 | DOI:10.1210/clinem/dgac002 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - January 12, 2022 Category: Endocrinology Authors: Aaron Chapla Jabasteen Johnson Sophy Korula Nisha Mohan Anish Ahmed Deny Varghese Parthiban Rangasamy Lavanya Ravichandran Felix Jebasingh Krishna Kumar Agrawal Noel Somasundaram Asha Hesarghatta Shyamasunder Sarah Mathai Anna Simon Sujeet Jha Subhankar C Source Type: research

Effect of daily Vitamin D3 Supplementation on Muscle Health: An Individual Participant Meta-Analysis
J Clin Endocrinol Metab. 2022 Jan 8:dgac004. doi: 10.1210/clinem/dgac004. Online ahead of print.ABSTRACTBACKGROUND: The role of vitamin D on muscle health is debated.METHODS: An individual participant metanalysis of four randomized placebo-controlled trials, investigating short term (three to nine months) effects of vitamin D3 in moderate (2800 IU) to high (7000 IU) daily oral doses on muscle health and quality of life (QoL). Inclusion criteria were either obesity (N=52), newly diagnosed primary hyperparathyroidism (N=41), Graves' disease (N=86) or secondary hyperparathyroidism (N=81).RESULTS: Overall (N=260) as well as in...
Source: The Journal of Clinical Endocrinology and Metabolism - January 12, 2022 Category: Endocrinology Authors: Lise Sofie Bislev Louise Wamberg Lars Rolighed Diana Grove-Laugesen Lars Rejnmark Source Type: research

Letter to the Editor From Singhania et al: "Diabetes Increases Severe COVID-19 Outcomes Primarily in Younger Adults"
J Clin Endocrinol Metab. 2022 Jan 8:dgab918. doi: 10.1210/clinem/dgab918. Online ahead of print.NO ABSTRACTPMID:35018443 | DOI:10.1210/clinem/dgab918 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - January 12, 2022 Category: Endocrinology Authors: Pankaj Singhania Rana Bhattacharjee Source Type: research

The Role of Morning Plasma Cortisol in Obesity: A Bi-directional Mendelian Randomization Study
J Clin Endocrinol Metab. 2022 Jan 9:dgac008. doi: 10.1210/clinem/dgac008. Online ahead of print.ABSTRACTCONTEXT: Cortisol, an important hormone regulated by the hypothalamic-pituitary-adrenal (HPA) axis, is associated with obesity. However, it is unclear whether the relationship between cortisol and obesity is causal or could be explained by reverse causality.OBJECTIVE: This work aims to assess the role of morning plasma cortisol in clinical classes of obesity.METHODS: In this bi-directional two-sample Mendelian Randomization (MR) study, cortisol-associated genetic variants were obtained from the CORtisol NETwork consortiu...
Source: The Journal of Clinical Endocrinology and Metabolism - January 12, 2022 Category: Endocrinology Authors: Xiaohui Qi Bin Cui Min Cao Source Type: research

Discriminative capacity of volumetry by CT scan to identify autonomous cortisol secretion in incidental adrenal adenomas
J Clin Endocrinol Metab. 2022 Jan 10:dgac005. doi: 10.1210/clinem/dgac005. Online ahead of print.ABSTRACTCONTEXT: Incidentally discovered adrenal adenomas are common. Assessment for possible autonomous cortisol excess (ACS) is warranted for all adrenal adenomas given the association with increased cardiometabolic disease.OBJECTIVE: To evaluate the discriminatory capacity of three-dimensional volumetry on computed tomography (CT) to identify ACS.DESIGN, SETTING, PATIENTS: Two radiologists, blinded to hormonal levels, prospectively analyzed CT images on 149 adult patients with unilateral, incidentally-discovered, adrenal ade...
Source: The Journal of Clinical Endocrinology and Metabolism - January 12, 2022 Category: Endocrinology Authors: Roberto Olmos Nicol ás Mertens Anand Vaidya Thomas Uslar Paula Fernandez Francisco J Guarda Álvaro Zúñiga Ignacio San Francisco Alvaro Huete Ren é Baudrand Source Type: research

Corrigendum to: Role of SIRT1 and Progesterone Resistance in Normal and Abnormal Endometrium
J Clin Endocrinol Metab. 2022 Jan 11:dgab880. doi: 10.1210/clinem/dgab880. Online ahead of print.NO ABSTRACTPMID:35021217 | DOI:10.1210/clinem/dgab880 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - January 12, 2022 Category: Endocrinology Source Type: research

Mapping the cord blood transcriptome of pregnancies affected by early maternal anemia to identify signatures of fetal programming
CONCLUSIONS: Our data provide proof-of-concept on distinct transcriptional and epigenetic changes detectable in UCB from newborns exposed to maternal EP anemia.PMID:35021220 | DOI:10.1210/clinem/dgac010 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - January 12, 2022 Category: Endocrinology Authors: Gad Hatem Line Hjort Olof Asplund Daniel T R Minja Omari Abdul Msemo Sofie Lykke M øller Thomas Lavstsen Louise Groth-Grunnet John P A Lusingu Ola Hansson Dirk Lund Christensen Allan A Vaag Isabella Artner Thor Theander Leif Groop Christentze Schmiegelow Source Type: research

Severe Hypoglycemia Increases Dementia Risk and Related Mortality: A Nationwide, Population-Based Cohort Study
J Clin Endocrinol Metab. 2022 Jan 6:dgab860. doi: 10.1210/clinem/dgab860. Online ahead of print.ABSTRACTCONTEXT: There are few studies focused on the relationship between hypoglycemia and new-onset dementia in patients with type 2 diabetes and no study regarding mortality of dementia after hypoglycemia.OBJECTIVE: We investigated the effect of severe hypoglycemia on dementia subtypes and its relation to overall mortality in patients with type 2 diabetes.METHODS: We evaluated incident dementia, including Alzheimer disease and vascular dementia, among health checkup participants aged 40 years or older in the National Health I...
Source: The Journal of Clinical Endocrinology and Metabolism - January 11, 2022 Category: Endocrinology Authors: Eugene Han Kyung-do Han Byung-Wan Lee Eun Seok Kang Bong-Soo Cha Seung-Hyun Ko Yong-Ho Lee Source Type: research

Severe Hypoglycemia Increases Dementia Risk and Related Mortality: A Nationwide, Population-Based Cohort Study
J Clin Endocrinol Metab. 2022 Jan 6:dgab860. doi: 10.1210/clinem/dgab860. Online ahead of print.ABSTRACTCONTEXT: There are few studies focused on the relationship between hypoglycemia and new-onset dementia in patients with type 2 diabetes and no study regarding mortality of dementia after hypoglycemia.OBJECTIVE: We investigated the effect of severe hypoglycemia on dementia subtypes and its relation to overall mortality in patients with type 2 diabetes.METHODS: We evaluated incident dementia, including Alzheimer disease and vascular dementia, among health checkup participants aged 40 years or older in the National Health I...
Source: The Journal of Clinical Endocrinology and Metabolism - January 11, 2022 Category: Endocrinology Authors: Eugene Han Kyung-do Han Byung-Wan Lee Eun Seok Kang Bong-Soo Cha Seung-Hyun Ko Yong-Ho Lee Source Type: research

Sex-specific effect of maternal thyroid hormone trajectories on preschoolers' behavioral development: a birth cohort study
CONCLUSIONS: Maternal thyroid hormone trajectories impact preschool boys' behavioral development.PMID:34999790 | DOI:10.1210/clinem/dgab887 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - January 9, 2022 Category: Endocrinology Authors: Peixuan Li Yuzhu Teng Xue Ru Zijian Liu Yan Han Fangbiao Tao Kun Huang Source Type: research

Inflammation and mortality in COVID-19 hospitalized patients with and without type 2 diabetes
CONCLUSIONS: We show that mortality in COVID19 patients is associated with elevated serum levels of innate inflammatory cytokine IL-6 and inflammatory chemokines IL-8 and IP10. This relationship is consistent across strata of diabetes, suggesting interventions targeting these innate immune pathways could potentially also benefit patients with diabetes.PMID:34999821 | DOI:10.1210/clinem/dgac003 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - January 9, 2022 Category: Endocrinology Authors: Jia Guo Wen-Hsuan W Lin Jason E Zucker Renu Nandakumar Anne-Catrin Uhlemann Shuang Wang Rupak Shivakoti Source Type: research

Sexual dimorphism in small-intestinal neuroendocrine tumors: lower prevalence of mesenteric disease in premenopausal women
J Clin Endocrinol Metab. 2022 Jan 6:dgac001. doi: 10.1210/clinem/dgac001. Online ahead of print.ABSTRACTCONTEXT: Small intestinal neuroendocrine tumors (SI-NETs) have a modest but significantly higher prevalence and worse prognosis in male patients.OBJECTIVE: This work aims to increase understanding of this sexual dimorphism in SI-NETs.PATIENTS AND METHODS: Retrospectively, SI-NET patients treated in a single tertiary center were included and analyzed for disease characteristics. Estrogen receptor 1 (ESR1) and 2 (ESR2), progesterone receptor (PGR) and androgen receptor (AR) mRNA expression was assessed in primary tumors an...
Source: The Journal of Clinical Endocrinology and Metabolism - January 9, 2022 Category: Endocrinology Authors: Anela Bla žević Anand M Iyer Marie-Louise F van Velthuysen Johannes Hofland Lindsey Oudijk Wouter W de Herder Leo J Hofland Richard A Feelders Source Type: research

Sex-specific effect of maternal thyroid hormone trajectories on preschoolers' behavioral development: a birth cohort study
CONCLUSIONS: Maternal thyroid hormone trajectories impact preschool boys' behavioral development.PMID:34999790 | DOI:10.1210/clinem/dgab887 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - January 9, 2022 Category: Endocrinology Authors: Peixuan Li Yuzhu Teng Xue Ru Zijian Liu Yan Han Fangbiao Tao Kun Huang Source Type: research

Inflammation and mortality in COVID-19 hospitalized patients with and without type 2 diabetes
CONCLUSIONS: We show that mortality in COVID19 patients is associated with elevated serum levels of innate inflammatory cytokine IL-6 and inflammatory chemokines IL-8 and IP10. This relationship is consistent across strata of diabetes, suggesting interventions targeting these innate immune pathways could potentially also benefit patients with diabetes.PMID:34999821 | DOI:10.1210/clinem/dgac003 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - January 9, 2022 Category: Endocrinology Authors: Jia Guo Wen-Hsuan W Lin Jason E Zucker Renu Nandakumar Anne-Catrin Uhlemann Shuang Wang Rupak Shivakoti Source Type: research

Sexual dimorphism in small-intestinal neuroendocrine tumors: lower prevalence of mesenteric disease in premenopausal women
J Clin Endocrinol Metab. 2022 Jan 6:dgac001. doi: 10.1210/clinem/dgac001. Online ahead of print.ABSTRACTCONTEXT: Small intestinal neuroendocrine tumors (SI-NETs) have a modest but significantly higher prevalence and worse prognosis in male patients.OBJECTIVE: This work aims to increase understanding of this sexual dimorphism in SI-NETs.PATIENTS AND METHODS: Retrospectively, SI-NET patients treated in a single tertiary center were included and analyzed for disease characteristics. Estrogen receptor 1 (ESR1) and 2 (ESR2), progesterone receptor (PGR) and androgen receptor (AR) mRNA expression was assessed in primary tumors an...
Source: The Journal of Clinical Endocrinology and Metabolism - January 9, 2022 Category: Endocrinology Authors: Anela Bla žević Anand M Iyer Marie-Louise F van Velthuysen Johannes Hofland Lindsey Oudijk Wouter W de Herder Leo J Hofland Richard A Feelders Source Type: research

Approach To The Pediatric Patient: Central Diabetes Insipidus
J Clin Endocrinol Metab. 2022 Jan 5:dgab930. doi: 10.1210/clinem/dgab930. Online ahead of print.ABSTRACTCentral diabetes insipidus (CDI) is a complex disorder in which large volumes of dilute urine are excreted due to arginine-vasopressin deficiency, and it is caused by a variety of disorders affecting the hypothalamic-posterior pituitary network. The differential diagnosis is challenging and requires a detailed medical history, physical examination, biochemical approach, imaging studies and, in some cases, histological confirmation. Magnetic resonance imaging is the gold standard method for evaluating congenital or acquir...
Source: The Journal of Clinical Endocrinology and Metabolism - January 7, 2022 Category: Endocrinology Authors: Giuseppa Patti Flavia Napoli Daniela Fava Emilio Casalini Natascia Di Iorgi Mohamad Maghnie Source Type: research

Approach To The Pediatric Patient: Central Diabetes Insipidus
J Clin Endocrinol Metab. 2022 Jan 5:dgab930. doi: 10.1210/clinem/dgab930. Online ahead of print.ABSTRACTCentral diabetes insipidus (CDI) is a complex disorder in which large volumes of dilute urine are excreted due to arginine-vasopressin deficiency, and it is caused by a variety of disorders affecting the hypothalamic-posterior pituitary network. The differential diagnosis is challenging and requires a detailed medical history, physical examination, biochemical approach, imaging studies and, in some cases, histological confirmation. Magnetic resonance imaging is the gold standard method for evaluating congenital or acquir...
Source: The Journal of Clinical Endocrinology and Metabolism - January 7, 2022 Category: Endocrinology Authors: Giuseppa Patti Flavia Napoli Daniela Fava Emilio Casalini Natascia Di Iorgi Mohamad Maghnie Source Type: research

Metabolic Profiling Of Obesity With And Without The Metabolic Syndrome - A Multi-Sample Evaluation
J Clin Endocrinol Metab. 2022 Jan 4:dgab922. doi: 10.1210/clinem/dgab922. Online ahead of print.ABSTRACTCONTEXT: There is a dispute whether obesity without major metabolic derangements may represent a benign condition or not.OBJECTIVE: We aimed to compare the plasma metabolome in obese subjects without the metabolic syndrome (MetS) to normal-weight subjects without MetS, as well as to obese subjects with MetS.DESIGN: Cross-sectional.SETTING: Two academic centers in Sweden.PARTICIPANTS: Three population-based samples (EpiHealth, n=2342, SCAPIS-Uppsala, n=4985 and SCAPIS-Malmö, n=3978) in which individuals were divided ...
Source: The Journal of Clinical Endocrinology and Metabolism - January 5, 2022 Category: Endocrinology Authors: Lars Lind Samira Salihovic Johan Sundstr öm S ölve Elmståhl Ulf Hammar Koen Dekkers Johan Ärnlöv J Gustav Smith Gunnar Engstr öm Tove Fall Source Type: research

Letter to the Editor from Jialal: "Higher Incidence of Metabolic Syndrome in Black Women with Polycystic Ovary Disease: A longitudinal Study"
J Clin Endocrinol Metab. 2022 Jan 3:dgab935. doi: 10.1210/clinem/dgab935. Online ahead of print.NO ABSTRACTPMID:34979022 | DOI:10.1210/clinem/dgab935 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - January 3, 2022 Category: Endocrinology Authors: Ishwarlal Jialal Source Type: research

Response Letter to the Editor from Ishwarlal Jialal: "Higher Incidence of Metabolic Syndrome in Black Women with Polycystic Ovary Disease: A Longitudinal Study
J Clin Endocrinol Metab. 2022 Jan 3:dgab936. doi: 10.1210/clinem/dgab936. Online ahead of print.NO ABSTRACTPMID:34979554 | DOI:10.1210/clinem/dgab936 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - January 3, 2022 Category: Endocrinology Authors: Iris Lee Anuja Dokras Source Type: research

Obesity Modifies the Performance of Fibrosis Biomarkers in Nonalcoholic Fatty Liver Disease
J Clin Endocrinol Metab. 2021 Dec 31:dgab933. doi: 10.1210/clinem/dgab933. Online ahead of print.ABSTRACTCONTEXT: Guidelines recommend blood-based fibrosis biomarkers to identify advanced nonalcoholic fatty liver disease (NAFLD), which is particularly prevalent in patients with obesity.OBJECTIVE: To study whether the degree of obesity affects the performance of liver fibrosis biomarkers in NAFLD.DESIGN: Cross-sectional cohort study comparing simple fibrosis scores (FIB-4, NFS, APRI, BARD, HFS) and newer scores incorporating neo-epitope biomarkers PRO-C3 (ADAPT, FIBC3) or CK-18 (MACK-3).SETTING: Tertiary referral center.PAT...
Source: The Journal of Clinical Endocrinology and Metabolism - December 31, 2021 Category: Endocrinology Authors: Sami Qadri Noora Ahlholm Ida L ønsmann Paola Pellegrini Anni Poikola Panu K Luukkonen Kimmo Porthan Anne Juuti Henna Sammalkorpi Anne K Penttil ä Roberta D'Ambrosio Giorgio Soardo Diana J Leeming Morten Karsdal Johanna Arola Stergios Kechagias Serena Pe Source Type: research

Novel lipidomic signature associated with metabolic risk in women with and without polycystic ovary syndrome
CONCLUSIONS: Our data indicate that a distinct lipidomic signature comprising high LPI(18:0) and low DHA-containing lipids are associated with key metabolic risk factors that cluster in PCOS, independent of PCOS status. Prospective studies are needed to corroborate these findings in larger cohorts of women with varying PCOS phenotypes.PMID:34971378 | DOI:10.1210/clinem/dgab931 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - December 31, 2021 Category: Endocrinology Authors: Aya Mousa Kevin Huynh Stacey J Ellery Boyd J Strauss Anju E Joham Barbora de Courten Peter J Meikle Helena J Teede Source Type: research

Incident diabetes risk is not increased in transgender individuals using hormone therapy
CONCLUSION: Despite studies reporting an increase in insulin resistance in feminizing hormone therapy and a decrease in insulin resistance in masculinizing hormone therapy, the incidence of diabetes in transgender individuals after initiation of hormone therapy was not different compared to the general population.PMID:34971391 | DOI:10.1210/clinem/dgab934 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - December 31, 2021 Category: Endocrinology Authors: Daan van Velzen Chantal Wiepjes Nienke Nota Daniel van Raalte Ren ée de Mutsert Suat Simsek Martin den Heijer Source Type: research

PNC2 (SLC25A36) deficiency associated with the hyperinsulinism/hyperammonemia syndrome
CONCLUSIONS: We report for the first time a mutation in PNC2/SLC25A36 leading to HI/HA and provide functional evidence of the molecular mechanism responsible for this phenotype. Our findings underscore the importance of mitochondrial nucleotide metabolism and expand the role of mitochondrial transporters in insulin secretion.PMID:34971397 | DOI:10.1210/clinem/dgab932 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - December 31, 2021 Category: Endocrinology Authors: Maher A Shahrour Francesco Massimo Lasorsa Vito Porcelli Imad Dweikat Maria Antonietta Di Noia Michal Gur Giulia Agostino Avraham Shaag Teresa Rinaldi Giuseppe Gasparre Flora Guerra Alessandra Castegna Simona Todisco Bassam Abu-Libdeh Orly Elpeleg Luigi P Source Type: research

Obesity Modifies the Performance of Fibrosis Biomarkers in Nonalcoholic Fatty Liver Disease
J Clin Endocrinol Metab. 2021 Dec 31:dgab933. doi: 10.1210/clinem/dgab933. Online ahead of print.ABSTRACTCONTEXT: Guidelines recommend blood-based fibrosis biomarkers to identify advanced nonalcoholic fatty liver disease (NAFLD), which is particularly prevalent in patients with obesity.OBJECTIVE: To study whether the degree of obesity affects the performance of liver fibrosis biomarkers in NAFLD.DESIGN: Cross-sectional cohort study comparing simple fibrosis scores (FIB-4, NFS, APRI, BARD, HFS) and newer scores incorporating neo-epitope biomarkers PRO-C3 (ADAPT, FIBC3) or CK-18 (MACK-3).SETTING: Tertiary referral center.PAT...
Source: The Journal of Clinical Endocrinology and Metabolism - December 31, 2021 Category: Endocrinology Authors: Sami Qadri Noora Ahlholm Ida L ønsmann Paola Pellegrini Anni Poikola Panu K Luukkonen Kimmo Porthan Anne Juuti Henna Sammalkorpi Anne K Penttil ä Roberta D'Ambrosio Giorgio Soardo Diana J Leeming Morten Karsdal Johanna Arola Stergios Kechagias Serena Pe Source Type: research

Novel lipidomic signature associated with metabolic risk in women with and without polycystic ovary syndrome
CONCLUSIONS: Our data indicate that a distinct lipidomic signature comprising high LPI(18:0) and low DHA-containing lipids are associated with key metabolic risk factors that cluster in PCOS, independent of PCOS status. Prospective studies are needed to corroborate these findings in larger cohorts of women with varying PCOS phenotypes.PMID:34971378 | DOI:10.1210/clinem/dgab931 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - December 31, 2021 Category: Endocrinology Authors: Aya Mousa Kevin Huynh Stacey J Ellery Boyd J Strauss Anju E Joham Barbora de Courten Peter J Meikle Helena J Teede Source Type: research

Incident diabetes risk is not increased in transgender individuals using hormone therapy
CONCLUSION: Despite studies reporting an increase in insulin resistance in feminizing hormone therapy and a decrease in insulin resistance in masculinizing hormone therapy, the incidence of diabetes in transgender individuals after initiation of hormone therapy was not different compared to the general population.PMID:34971391 | DOI:10.1210/clinem/dgab934 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - December 31, 2021 Category: Endocrinology Authors: Daan van Velzen Chantal Wiepjes Nienke Nota Daniel van Raalte Ren ée de Mutsert Suat Simsek Martin den Heijer Source Type: research

PNC2 (SLC25A36) deficiency associated with the hyperinsulinism/hyperammonemia syndrome
CONCLUSIONS: We report for the first time a mutation in PNC2/SLC25A36 leading to HI/HA and provide functional evidence of the molecular mechanism responsible for this phenotype. Our findings underscore the importance of mitochondrial nucleotide metabolism and expand the role of mitochondrial transporters in insulin secretion.PMID:34971397 | DOI:10.1210/clinem/dgab932 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - December 31, 2021 Category: Endocrinology Authors: Maher A Shahrour Francesco Massimo Lasorsa Vito Porcelli Imad Dweikat Maria Antonietta Di Noia Michal Gur Giulia Agostino Avraham Shaag Teresa Rinaldi Giuseppe Gasparre Flora Guerra Alessandra Castegna Simona Todisco Bassam Abu-Libdeh Orly Elpeleg Luigi P Source Type: research

Obesity Modifies the Performance of Fibrosis Biomarkers in Nonalcoholic Fatty Liver Disease
J Clin Endocrinol Metab. 2021 Dec 31:dgab933. doi: 10.1210/clinem/dgab933. Online ahead of print.ABSTRACTCONTEXT: Guidelines recommend blood-based fibrosis biomarkers to identify advanced nonalcoholic fatty liver disease (NAFLD), which is particularly prevalent in patients with obesity.OBJECTIVE: To study whether the degree of obesity affects the performance of liver fibrosis biomarkers in NAFLD.DESIGN: Cross-sectional cohort study comparing simple fibrosis scores (FIB-4, NFS, APRI, BARD, HFS) and newer scores incorporating neo-epitope biomarkers PRO-C3 (ADAPT, FIBC3) or CK-18 (MACK-3).SETTING: Tertiary referral center.PAT...
Source: The Journal of Clinical Endocrinology and Metabolism - December 31, 2021 Category: Endocrinology Authors: Sami Qadri Noora Ahlholm Ida L ønsmann Paola Pellegrini Anni Poikola Panu K Luukkonen Kimmo Porthan Anne Juuti Henna Sammalkorpi Anne K Penttil ä Roberta D'Ambrosio Giorgio Soardo Diana J Leeming Morten Karsdal Johanna Arola Stergios Kechagias Serena Pe Source Type: research