Impact of Insulin-Induced Relative Hypoglycemia on Vascular Insulin Sensitivity and Central Hemodynamics in Prediabetes
CONCLUSION: Compared with NG, insulin-induced RH corresponded with a blunted rise in HR and drop in Pf during insulin infusion in adults with PD, independent of changes in peripheral endothelial function.PMID:38491968 | DOI:10.1210/clinem/dgae152 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 16, 2024 Category: Endocrinology Authors: Daniel J Battillo Mary-Margaret E Remchak Ankit M Shah Steven K Malin Source Type: research

Age-related curves of AMH using the Gen II, the picoAMH and the Elecsys assays in women with polycystic ovary syndrome
CONCLUSIONS: To our knowledge this is the first study reporting age specific percentile nomograms of serum AMH levels measured by the Gen II, the picoAMH and the Elecsys assays in a large population of PCOS women. These findings may help to interpret AMH levels in PCOS patients and facilitate the use of AMH as a diagnostic tool across age ranges.PMID:38486510 | DOI:10.1210/clinem/dgae153 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 15, 2024 Category: Endocrinology Authors: Federica Barbagallo Kim van der Ham Sten P Willemsen Yvonne V Louwers Joop S Laven Source Type: research

Impact of breastfeeding duration on coagulation in women with and without history of gestational diabetes mellitus
CONCLUSION: Longer duration of breastfeeding is associated with lower cardiovascular risk and an improved coagulation profile. Women with GDM history appear to benefit particularly from prolonged breastfeeding.PMID:38487818 | DOI:10.1210/clinem/dgae172 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 15, 2024 Category: Endocrinology Authors: Louise Fritsche Dorina L öffler Konstantinos Kantartzis Gesine Flehmig Michael Roden Andreas Fritsche Andreas L Birkenfeld Andreas Peter Martin Heni Sebastian H örber Source Type: research

The 13C glucose breath test accurately identifies insulin resistance in people with type 1 diabetes
CONCLUSIONS: Under euglycemic conditions, the 13C-GBT accurately identified individuals with type 1 diabetes and concurrent IR, suggesting its potential as a valuable non-invasive index.PMID:38487831 | DOI:10.1210/clinem/dgae175 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 15, 2024 Category: Endocrinology Authors: Jonathan Mertens Laurence Roosens Rie Braspenning Joeri Vandebeeck Sven Francque Christophe De Block Source Type: research

The impact of glucagon-like peptide-1 receptor agonists (GLP-1 RA) on weight loss following bariatric treatment: a systematic review and meta-analysis
CONCLUSIONS: Our findings suggest that the use of liraglutide and semaglutide in patients who previously underwent MBS can promote significant weight reduction with acceptable safety profile.TRIAL REGISTRATION: CRD42023450024.PMID:38488042 | DOI:10.1210/clinem/dgae176 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 15, 2024 Category: Endocrinology Authors: Caroline K Kramer Matthew Retnakaran Luciana V Viana Source Type: research

Moderate-Intensity Combined Training Induces Lipidomic Changes in Individuals with Obesity and Type 2 Diabetes
CONCLUSION: Our study stated that 16 weeks of moderate-intensity CT remodelled the lipid metabolism in OB, and T2D individuals, even without dietary intervention, establishing a link between exercise-modulated lipid markers and mechanisms that reduce IR and obesity-related comorbidities.PMID:38488044 | DOI:10.1210/clinem/dgae177 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 15, 2024 Category: Endocrinology Authors: Renata Garbellini Duft Ivan Luiz Padilha Bonfante Susana Alejandra Palma-Duran Mara Patr ícia Traina Chacon-Mikahil Julian Leether Griffin Cl áudia Regina Cavaglieri Source Type: research

Effects of Supplemental Vitamin D3, Omega-3 Fatty Acids on Physical Performance Measures in VITamin D and OmegA-3 TriaL
CONCLUSIONS: Neither supplemental vitamin D3 nor marine omega-3 fatty acids for 2 years improved physical performance in this generally healthy adult population.PMID:38488491 | DOI:10.1210/clinem/dgae150 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 15, 2024 Category: Endocrinology Authors: Sharon H Chou Nancy R Cook Gregory Kotler Eunjung Kim Trisha Copeland I-Min Lee Peggy M Cawthon Julie E Buring JoAnn E Manson Meryl S LeBoff Source Type: research

Age-related curves of AMH using the Gen II, the picoAMH and the Elecsys assays in women with polycystic ovary syndrome
CONCLUSIONS: To our knowledge this is the first study reporting age specific percentile nomograms of serum AMH levels measured by the Gen II, the picoAMH and the Elecsys assays in a large population of PCOS women. These findings may help to interpret AMH levels in PCOS patients and facilitate the use of AMH as a diagnostic tool across age ranges.PMID:38486510 | DOI:10.1210/clinem/dgae153 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 15, 2024 Category: Endocrinology Authors: Federica Barbagallo Kim van der Ham Sten P Willemsen Yvonne V Louwers Joop S Laven Source Type: research

Impact of breastfeeding duration on coagulation in women with and without history of gestational diabetes mellitus
CONCLUSION: Longer duration of breastfeeding is associated with lower cardiovascular risk and an improved coagulation profile. Women with GDM history appear to benefit particularly from prolonged breastfeeding.PMID:38487818 | DOI:10.1210/clinem/dgae172 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 15, 2024 Category: Endocrinology Authors: Louise Fritsche Dorina L öffler Konstantinos Kantartzis Gesine Flehmig Michael Roden Andreas Fritsche Andreas L Birkenfeld Andreas Peter Martin Heni Sebastian H örber Source Type: research

The 13C glucose breath test accurately identifies insulin resistance in people with type 1 diabetes
CONCLUSIONS: Under euglycemic conditions, the 13C-GBT accurately identified individuals with type 1 diabetes and concurrent IR, suggesting its potential as a valuable non-invasive index.PMID:38487831 | DOI:10.1210/clinem/dgae175 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 15, 2024 Category: Endocrinology Authors: Jonathan Mertens Laurence Roosens Rie Braspenning Joeri Vandebeeck Sven Francque Christophe De Block Source Type: research

The impact of glucagon-like peptide-1 receptor agonists (GLP-1 RA) on weight loss following bariatric treatment: a systematic review and meta-analysis
CONCLUSIONS: Our findings suggest that the use of liraglutide and semaglutide in patients who previously underwent MBS can promote significant weight reduction with acceptable safety profile.TRIAL REGISTRATION: CRD42023450024.PMID:38488042 | DOI:10.1210/clinem/dgae176 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 15, 2024 Category: Endocrinology Authors: Caroline K Kramer Matthew Retnakaran Luciana V Viana Source Type: research

Moderate-Intensity Combined Training Induces Lipidomic Changes in Individuals with Obesity and Type 2 Diabetes
CONCLUSION: Our study stated that 16 weeks of moderate-intensity CT remodelled the lipid metabolism in OB, and T2D individuals, even without dietary intervention, establishing a link between exercise-modulated lipid markers and mechanisms that reduce IR and obesity-related comorbidities.PMID:38488044 | DOI:10.1210/clinem/dgae177 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 15, 2024 Category: Endocrinology Authors: Renata Garbellini Duft Ivan Luiz Padilha Bonfante Susana Alejandra Palma-Duran Mara Patr ícia Traina Chacon-Mikahil Julian Leether Griffin Cl áudia Regina Cavaglieri Source Type: research

Effects of Supplemental Vitamin D3, Omega-3 Fatty Acids on Physical Performance Measures in VITamin D and OmegA-3 TriaL
CONCLUSIONS: Neither supplemental vitamin D3 nor marine omega-3 fatty acids for 2 years improved physical performance in this generally healthy adult population.PMID:38488491 | DOI:10.1210/clinem/dgae150 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 15, 2024 Category: Endocrinology Authors: Sharon H Chou Nancy R Cook Gregory Kotler Eunjung Kim Trisha Copeland I-Min Lee Peggy M Cawthon Julie E Buring JoAnn E Manson Meryl S LeBoff Source Type: research

Critical Role for 24-Hydroxylation in Homeostatic Regulation of Vitamin D Metabolism
CONCLUSIONS: Suppression of 24-hydroxylase provides a first line of defense against symptomatic VitD-deficiency by decreasing metabolic clearance of 1,25(OH)2D. The 1,25(OH)2D/24,25(OH)2D ratio provides a useful index of VitD status since it incorporates 24,25(OH)2D levels and therefore, provides insight into 24-hydroxylase activity. When VitD availability is limited, this suppresses 24-hydroxylase activity - thereby decreasing the level of 24,25(OH)2D and increasing the 1,25(OH)2D/24,25(OH)2D ratio. Thus, an increased 1,25(OH)2D/24,25(OH)2D ratio signifies triggering of homeostatic regulation, which occurs at early stages...
Source: The Journal of Clinical Endocrinology and Metabolism - March 14, 2024 Category: Endocrinology Authors: Zhinous Shahidzadeh Yazdi Elizabeth A Streeten Hilary B Whitlatch May E Montasser Amber L Beitelshees Simeon I Taylor Source Type: research

Elagolix Represents a Less Invasive and Cheaper Option than Injectable GnRH Antagonist for Ovulation Suppression in IVF
CONCLUSIONS: Oral GnRH antagonist, a much cheaper and less invasive medication that is used at a lower frequency, showed comparable ovulation suppression to the costly injectable GnRH antagonist. Further studies are required to evaluate the effect of oral GnRH antagonist on endometrial lining receptivity and pregnancy outcomes especially when using fresh embryo transfer IVF protocols.PMID:38482566 | DOI:10.1210/clinem/dgae168 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 14, 2024 Category: Endocrinology Authors: Marco Mouanness Zaher Merhi Source Type: research