Maintenance of Acromegaly Control in Patients Switching From Injectable Somatostatin Receptor Ligands to Oral Octreotide.
Abstract PURPOSE: The phase 3 CHIASMA OPTIMAL trial (NCT03252353) evaluated efficacy and safety of oral octreotide capsules (OOCs) in patients with acromegaly who previously demonstrated biochemical control while receiving injectable somatostatin receptor ligands (SRLs). METHODS: In this double-blind study, patients (N = 56) stratified by prior SRL dose were randomly assigned 1:1 to OOC or placebo for 36 weeks. The primary end point was maintenance of biochemical control at the end of treatment (mean insulin-like growth factor 1 [IGF-1] ≤ 1.0 × upper limit of normal [ULN]; weeks 34 and 36). Tim...
Source: The Journal of Clinical Endocrinology and Metabolism - September 5, 2020 Category: Endocrinology Authors: Samson SL, Nachtigall LB, Fleseriu M, Gordon MB, Bolanowski M, Labadzhyan A, Ur E, Molitch M, Ludlam WH, Patou G, Haviv A, Biermasz N, Giustina A, Trainer PJ, Strasburger CJ, Kennedy L, Melmed S Tags: J Clin Endocrinol Metab Source Type: research

Effect of Teriparatide on Bone Remodeling and Density in Premenopausal Idiopathic Osteoporosis: A Phase II Trial.
CONCLUSIONS: Teriparatide increased BFR and formation markers and was associated with marked aBMD improvements in most premenopausal women (82%) with IOP. PMID: 32876328 [PubMed - in process] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - September 4, 2020 Category: Endocrinology Authors: Cohen A, Shiau S, Nair N, Recker RR, Lappe JM, Dempster DW, Nickolas TL, Zhou H, Agarwal S, Kamanda-Kosseh M, Bucovsky M, Williams JM, McMahon DJ, Stubby J, Shane E Tags: J Clin Endocrinol Metab Source Type: research

Omega 3 Improves Both apoB100-containing Lipoprotein Turnover and their Sphingolipid Profile in Hypertriglyceridemia.
CONCLUSION: Based on these results, we hypothesize that the improvement in apoB100 metabolism during n-3 LC-PUFA supplementation is contributed to by changes in sphingolipids. PMID: 32805740 [PubMed - in process] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - August 19, 2020 Category: Endocrinology Authors: Ferchaud-Roucher V, Zair Y, Aguesse A, Krempf M, Ouguerram K Tags: J Clin Endocrinol Metab Source Type: research

Fertility and Pregnancy Outcomes in Women with Polycystic Ovary Syndrome Following Bariatric Surgery.
CONCLUSIONS: Pregnancy and fertility rates in very obese women with PCOS after bariatric surgery were high, with few maternal and neonatal complications. PMID: 32754732 [PubMed - in process] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - August 13, 2020 Category: Endocrinology Authors: Benito E, Gómez-Martin JM, Vega-Piñero B, Priego P, Galindo J, Escobar-Morreale HF, Botella-Carretero JI Tags: J Clin Endocrinol Metab Source Type: research

HDL Cholesterol Efflux Capacity is Impaired in Severe Short-Term Hypothyroidism Despite Increased HDL Cholesterol.
Abstract CONTEXT: Severe hypothyroidism has profound effects on lipoprotein metabolism including high-density lipoprotein (HDL) cholesterol elevations but effects on HDL function metrics are unknown. OBJECTIVE: To determine the impact of severe short-term hypothyroidism on HDL particle characteristics, HDL cholesterol efflux capacity (CEC), and HDL antioxidative capacity. DESIGN: Observational study with variables measured during severe short-term hypothyroidism (median TSH 81 mU/L) and after 20 weeks of thyroid hormone supplementation (median TSH 0.03 mU/L) (Netherlands Trial Registry ID 7228). SET...
Source: The Journal of Clinical Endocrinology and Metabolism - August 13, 2020 Category: Endocrinology Authors: van der Boom T, Jia C, Lefrandt JD, Connelly MA, Links TP, Tietge UJF, Dullaart RPF Tags: J Clin Endocrinol Metab Source Type: research

Opioids and the Hypothalamic-Pituitary-Gonadal (HPG) Axis.
CONCLUSIONS: Despite the high prevalence of OIH, it remains underrecognized and undertreated with multiple endocrine and metabolic consequences. A reasonable approach in patients using opioids includes informing them of this complication and its potential consequences, screening for signs and symptoms of hypogonadism then sex hormone levels if prolonged opioid use> 3 months, and treating patients diagnosed with hypogonadism, if and when clinically indicated, with sex hormones if chronic opioids are planned to be continued for ≥ 6 months. PMID: 32770254 [PubMed - in process] (Source: The Journal of Clinical Endoc...
Source: The Journal of Clinical Endocrinology and Metabolism - August 13, 2020 Category: Endocrinology Authors: Wehbeh L, Dobs AS Tags: J Clin Endocrinol Metab Source Type: research

Approach to the Patient: Perioperative Management of the Patient with Pheochromocytoma or Sympathetic Paraganglioma.
Abstract Pheochromocytomas and sympathetic paraganglioma (PPGL) are rare chromaffin cell tumors originating in the adrenal medulla and sympathetic paraganglia, respectively, which share the capacity to synthesize and release catecholamines. The incidence of PPGL has increased in recent years. Surgical resection is the only curative treatment for PPGL. Management of patients with PPGL is complex and should be done by a specialized multidisciplinary team in centers with broad expertise. Surgical resection of a PPGL is a high-risk procedure for which optimal pretreatment with antihypertensive drugs is required in com...
Source: The Journal of Clinical Endocrinology and Metabolism - July 30, 2020 Category: Endocrinology Authors: Berends AMA, Kerstens MN, Lenders JWM, Timmers HJLM Tags: J Clin Endocrinol Metab Source Type: research

An Intronic HCP5 Variant Is Associated With Age of Onset and Susceptibility to Graves Disease in UK and Polish Cohorts.
Abstract CONTEXT: The genetic background of young-onset Graves disease (GD) remains largely unknown. An intronic variant in human leukocyte antigen (HLA) complex P5 (HCP5) has previously been associated with GD susceptibility and age of onset in a cohort of Polish patients. OBJECTIVE: We aimed to investigate the association of the HCP5 variant rs3094228 with GD susceptibility and age of onset in a UK cohort and conduct a meta-analysis of UK and Polish data. DESIGN AND PARTICIPANTS: rs3094228 was genotyped in 469 UK patients with GD using Taqman chemistry. Genotype frequencies were compared with genotypic...
Source: The Journal of Clinical Endocrinology and Metabolism - July 29, 2020 Category: Endocrinology Authors: Lane LC, Kuś A, Bednarczuk T, Bossowski A, Daroszewski J, Jurecka-Lubieniecka B, Cordell HJ, Pearce SHS, Cheetham T, Mitchell AL Tags: J Clin Endocrinol Metab Source Type: research

Pharmacodynamic studies of nasal tetracosactide with salivary glucocorticoids for a noninvasive Short Synacthen Test.
CONCLUSIONS: Nasal administration of Nasacthin003 generates equivalent plasma cortisol values to the 250-µg IV SST and, with measurement at 60 minutes of salivary cortisol or cortisone, provides a noninvasive test for adrenal insufficiency. PMID: 32593173 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - June 29, 2020 Category: Endocrinology Authors: Elder CJ, Vilela R, Johnson TN, Taylor RN, Kemp EH, Keevil BG, Cross AS, Ross RJ, Wright NP Tags: J Clin Endocrinol Metab Source Type: research

The Prevalence of Thyroid Dysfunction and Autoimmunity in Women With History of Miscarriage or Subfertility.
nning N, Robinson L, Ross J, Sizer A, Small R, Underwood M, Kilby MD, Daniels J, Thangaratinam S, Chan S, Boelaert K, Coomarasamy A Abstract OBJECTIVE: To describe the prevalence of and factors associated with different thyroid dysfunction phenotypes in women who are asymptomatic preconception. DESIGN: Observational cohort study. SETTING: A total of 49 hospitals across the United Kingdom between 2011 and 2016. PARTICIPANTS: Women aged 16 to 41years with history of miscarriage or subfertility trying for a pregnancy. METHODS: Prevalences and 95% confidence intervals (CIs) were estimated using the...
Source: The Journal of Clinical Endocrinology and Metabolism - June 29, 2020 Category: Endocrinology Authors: Dhillon-Smith RK, Tobias A, Smith PP, Middleton LJ, Sunner KK, Baker K, Farrell-Carver S, Bender-Atik R, Agrawal R, Bhatia K, Chu JJ, Edi-Osagie E, Ewies A, Ghobara T, Gupta P, Jurkovic D, Khalaf Y, Mulbagal K, Nunes N, Overton C, Quenby S, Rai R, Raine-F Tags: J Clin Endocrinol Metab Source Type: research

Commentary on: "The Presence of Active Brown Adipose Tissue Determines Cold-Induced Energy Expenditure and Oxylipin Profiles in Humans".
Commentary on: "The Presence of Active Brown Adipose Tissue Determines Cold-Induced Energy Expenditure and Oxylipin Profiles in Humans". J Clin Endocrinol Metab. 2020 Aug 01;105(8): Authors: Lynes MD, Tseng YH PMID: 32559764 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - June 20, 2020 Category: Endocrinology Authors: Lynes MD, Tseng YH Tags: J Clin Endocrinol Metab Source Type: research

ERRATUMERRATUM for "Effect of Abaloparatide vs Alendronate on Fracture Risk Reduction in Postmenopausal Women With Osteoporosis".
ERRATUMERRATUM for "Effect of Abaloparatide vs Alendronate on Fracture Risk Reduction in Postmenopausal Women With Osteoporosis". J Clin Endocrinol Metab. 2020 Aug 01;105(8): Authors: Leder BZ, Mitlak B, Hu MY, Hattersley G, Bockman RS PMID: 32516411 [PubMed - in process] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - June 12, 2020 Category: Endocrinology Authors: Leder BZ, Mitlak B, Hu MY, Hattersley G, Bockman RS Tags: J Clin Endocrinol Metab Source Type: research

Letter to the Editor: "Effect of Chronic Pancreatitis on Complications and Mortality in DM Patients: A 10-Year Nationwide Cohort Study".
Letter to the Editor: "Effect of Chronic Pancreatitis on Complications and Mortality in DM Patients: A 10-Year Nationwide Cohort Study". J Clin Endocrinol Metab. 2020 Jul 01;105(7): Authors: Liu Y, Chen HL, Li ZS, Wang D, Hu LH PMID: 32497218 [PubMed - in process] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - June 6, 2020 Category: Endocrinology Authors: Liu Y, Chen HL, Li ZS, Wang D, Hu LH Tags: J Clin Endocrinol Metab Source Type: research

Near-Adult Height After Growth Hormone Treatment in Children Born Prematurely-Data From KIGS.
ACS Abstract CONTEXT: Children born prematurely have been treated with growth hormone (GH), and a significant improvement in height during the first years of treatment has been described. OBJECTIVE: To evaluate the influence of prematurity on near-adult height (NAH) after GH treatment. DESIGN: KIGS (Pfizer International Growth Database) was queried for children born preterm treated with GH. SETTING: KIGS database. PATIENTS: A total of 586 children short in stature born preterm with various GH status and with available gestational age (GA), birth weight, and NAH, all treated with GH. INTERV...
Source: The Journal of Clinical Endocrinology and Metabolism - June 3, 2020 Category: Endocrinology Authors: Boguszewski MCS, Carlsson M, Lindberg A, Dahlgren J, Aydin F, Camacho-Hübner C, Hokken-Koelega ACS Tags: J Clin Endocrinol Metab Source Type: research

Remission of Pituitary Autoimmunity Induced by Gluten-Free Diet in Patients With Celiac Disease.
Abstract CONTEXT: An improvement of some autoimmune diseases associated with celiac disease (CD) has been observed after a gluten-free diet (GFD). OBJECTIVE: The aim of this longitudinal study was to evaluate the effect of a GFD on autoimmune pituitary impairment in patients with CD and potential/subclinical lymphocytic hypophysitis (LYH). DESIGN: Five-year longitudinal observational study. SETTING: Tertiary referral center for immunoendocrinology at the University of Campania "Luigi Vanvitelli". PATIENTS: Ninety-three newly diagnosed LYH patients (high titer of antipituitary antibodi...
Source: The Journal of Clinical Endocrinology and Metabolism - May 21, 2020 Category: Endocrinology Authors: Bellastella G, Maiorino MI, Cirillo P, Longo M, Pernice V, Costantino A, Annunziata C, Bellastella A, Esposito K, De Bellis A Tags: J Clin Endocrinol Metab Source Type: research

CATS II Long-term Anthropometric and Metabolic Effects of Maternal Sub-optimal Thyroid Function in Offspring and Mothers.
CONCLUSIONS: Levothyroxine supplementation of women with SGTF did not affect long-term offspring anthropometric, bone, and cardiometabolic measurements. However, absence of treatment was associated with sustained long-term increase in BMI and fat mass in women with SGTF. PMID: 32396189 [PubMed - in process] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - May 14, 2020 Category: Endocrinology Authors: Muller I, Taylor PN, Daniel RM, Hales C, Scholz A, Candler T, Pettit RJ, Evans WD, Shillabeer D, Draman MS, Dayan CM, Tang HKC, Okosieme O, Gregory JW, Lazarus JH, Rees DA, Ludgate ME Tags: J Clin Endocrinol Metab Source Type: research

Hypoparathyroidism.
CONCLUSIONS: Advances in our knowledge of hypoparathyroidism have led to greater understanding of the disease itself and our approach to it. PMID: 32322899 [PubMed - in process] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 24, 2020 Category: Endocrinology Authors: Bilezikian JP Tags: J Clin Endocrinol Metab Source Type: research

CORRIGENDUM for "Treatment of Children With GH in the United States and Europe: Long-Term Follow-Up From NordiNet ® IOS and ANSWER Program".
CORRIGENDUM for "Treatment of Children With GH in the United States and Europe: Long-Term Follow-Up From NordiNet® IOS and ANSWER Program". J Clin Endocrinol Metab. 2020 Jun 01;105(6): Authors: PMID: 32324865 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 24, 2020 Category: Endocrinology Tags: J Clin Endocrinol Metab Source Type: research

Pretreatment Endocrine Disorders Due to Optic Pathway Gliomas in Pediatric Neurofibromatosis Type 1: Multicenter Study.
CONCLUSIONS: Endocrine disorders were found in approximately one-third of patients with Neurofibromatosis type 1 and OPGs before any oncological treatment, central precocious puberty being the most prevalent. Sign of diencephalic syndrome and growth hormone hypersecretion, although rare, could be predictive of optic pathway gliomas in NF1. Tumor location was the most important predictor of endocrine disorders, particularly hypothalamic involvement. PMID: 32294191 [PubMed - in process] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 17, 2020 Category: Endocrinology Authors: Santoro C, Perrotta S, Picariello S, Scilipoti M, Cirillo M, Quaglietta L, Cinalli G, Cioffi D, Di Iorgi N, Maghnie M, Gallizia A, Parpagnoli M, Messa F, De Sanctis L, Vannelli S, Marzuillo P, Miraglia Del Giudice E, Grandone A Tags: J Clin Endocrinol Metab Source Type: research

The Genetic Basis of Thyroid Function: Novel Findings and New Approaches.
CONCLUSIONS: Recent genetic studies have greatly improved our understanding of the genetic basis of thyroid function, and have revealed novel pathways involved in its regulation. In addition, these findings have paved the way for various lines of research that can improve our understanding of thyroid hormone regulation and thyroid diseases, as well as the potential use of these markers in future clinical practice. PMID: 32271924 [PubMed - in process] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 11, 2020 Category: Endocrinology Authors: Kuś A, Chaker L, Teumer A, Peeters RP, Medici M Tags: J Clin Endocrinol Metab Source Type: research

Our Response to COVID-19 as Endocrinologists and Diabetologists.
PMID: 32232480 [PubMed - in process] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 3, 2020 Category: Endocrinology Authors: Kaiser UB, Mirmira RG, Stewart PM Tags: J Clin Endocrinol Metab Source Type: research

Does Hormone Therapy Protect the Heart? It Is a Stressful Question.
PMID: 32215563 [PubMed - in process] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 28, 2020 Category: Endocrinology Authors: Santoro N Tags: J Clin Endocrinol Metab Source Type: research

Insulin Autoimmune Syndrome: A Case of Clopidogrel-induced Autoimmune Hypoglycemia.
CONCLUSIONS: This case highlights a case of severe IAS. Given the ubiquity of clopidogrel, IAS should be remembered as a rare adverse effect. PMID: 32182368 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 18, 2020 Category: Endocrinology Authors: Calder GL, Ward GM, Sachithanandan N, MacIsaac RJ Tags: J Clin Endocrinol Metab Source Type: research

Clinical and Genetic Characterization of 153 Patients with Persistent or Transient Congenital Hyperinsulinism.
CONCLUSIONS: The genetic variants found in this nationwide CHI cohort are in agreement with previous studies, mutations in the KATP channel genes being the major causes of the disease. Pathogenic CHI-associated variants were not identified in patients who were both diazoxide responsive and able to discontinue medication within the first 4 months. Therefore, our results support the notion that genetic testing should be focused on patients with inadequate response or prolonged need for medication. PMID: 32170320 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 15, 2020 Category: Endocrinology Authors: Männistö JME, Maria M, Raivo J, Kuulasmaa T, Otonkoski T, Huopio H, Laakso M Tags: J Clin Endocrinol Metab Source Type: research

CORRIGENDUM FOR "A Case of Hashimoto's Thyroiditis with Multiple Drug Resistance and High Expression of Efflux Transporters".
CORRIGENDUM FOR "A Case of Hashimoto's Thyroiditis with Multiple Drug Resistance and High Expression of Efflux Transporters". J Clin Endocrinol Metab. 2020 Apr 01;105(4): Authors: PMID: 32170861 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 15, 2020 Category: Endocrinology Tags: J Clin Endocrinol Metab Source Type: research

CORRIGENDUM FOR "Estimated Association Between Cytokines and the Progression to Diabetes: 10-year Follow-up From a Community-Based Cohort".
CORRIGENDUM FOR "Estimated Association Between Cytokines and the Progression to Diabetes: 10-year Follow-up From a Community-Based Cohort". J Clin Endocrinol Metab. 2020 Apr 01;105(4): Authors: PMID: 32170862 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 15, 2020 Category: Endocrinology Tags: J Clin Endocrinol Metab Source Type: research

Determining the Prevalence of Primary Aldosteronism in Patients With New-Onset Type 2 Diabetes and Hypertension.
This study aimed to detect the prevalence of PA in patients with new-onset type 2 diabetes (T2D) and hypertension and to explore the association between PA and diabetes. METHODS: A total of 256 outpatients with new-onset T2D and hypertension were screened for PA. Plasma aldosterone concentration (PAC), plasma renin activity (PRA) were measured. Patients with an aldosterone renin activity ratio (ARR) ≥ 30 ng/dL/ng/mL/h and PAC ≥ 15 ng/dL underwent confirmatory captopril challenge test (CCT) for PA. The diagnostic criteria for PA were, after CCT, (1) PAC decreased
Source: The Journal of Clinical Endocrinology and Metabolism - March 14, 2020 Category: Endocrinology Authors: Hu Y, Zhang J, Liu W, Su X Tags: J Clin Endocrinol Metab Source Type: research

CORRIGENDUM FOR "Hippocampal Neurochemical Profile and Glucose Transport Kinetics in Patients With Type 1 Diabetes".
CORRIGENDUM FOR "Hippocampal Neurochemical Profile and Glucose Transport Kinetics in Patients With Type 1 Diabetes". J Clin Endocrinol Metab. 2020 Apr 01;105(4): Authors: PMID: 32154889 [PubMed - in process] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 12, 2020 Category: Endocrinology Tags: J Clin Endocrinol Metab Source Type: research

Heterozygous Mutation (Q459R) in the Calcium-Sensing Receptor Gene Causes Familial Hypocalciuric Hypercalcemia 1 (FHH1).
CONCLUSION: A loss-of-function Q459R mutation in CASR in a family caused FHH1 characterized by elevated ionized calcium and PTH and low calcium excretion. The marked presence of CaSR at the membrane and inhibition of IP1 signaling in vitro suggest that calcimimetics may be functional in patients with this mutation, which seems to be a mild loss-of-function mutation associated with autosomal dominant transmission of FHH1. PMID: 32160303 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 12, 2020 Category: Endocrinology Authors: Boisen IM, Mos I, Lerche-Black EM, Juul A, Bräuner-Osborne H, Blomberg Jensen M Tags: J Clin Endocrinol Metab Source Type: research

Association of Polymorphisms in the Kisspeptin/GPR54 Pathway Genes With Risk of Early Puberty in Chinese Girls.
Abstract CONTEXT AND OBJECTIVE: This case control study was designed to investigate the association between mutation of 10 single nucleotide polymorphism (SNP) loci (rs1132506, rs5780218, rs192636495, rs4889, rs184749, rs12985070, rs708910, rs932491, rs8074995, and rs2306877) in all 5 genes (KISS1, GPR54, PLCB1, PRKCA, and ITPR1) in the kisspeptin/GPR54 pathway and the risk of early puberty in Chinese Han girls. DESIGN AND PARTICIPANTS: A total of 314 pairs of early puberty girls on their first visit to hospital and age-matched controls (± 3 months) were recruited. The genotypes of each SNP were determ...
Source: The Journal of Clinical Endocrinology and Metabolism - March 12, 2020 Category: Endocrinology Authors: Li D, Wu Y, Cheng J, Liu L, Li X, Chen D, Huang S, Wen Y, Ke Y, Yao Y, Su Z, Zhou L Tags: J Clin Endocrinol Metab Source Type: research

Fractures, Bone Mineral Density, and Final Height in Craniopharyngioma Patients with a Follow-up of 16 Years.
CONCLUSIONS: Men with craniopharyngioma are at higher risk than women for fractures. In patients with craniopharyngioma, a very low BMD (T-score ≤-2.5 or Z-score ≤-2.0) seems not to be a good predictor for fracture risk. PMID: 32145029 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 8, 2020 Category: Endocrinology Authors: van Santen SS, Olsson DS, van den Heuvel-Eibrink MM, Wijnen M, Hammarstrand C, Janssen JAMJL, Johansson G, van der Lely AJ, Neggers SJCMM Tags: J Clin Endocrinol Metab Source Type: research

Glycemic measures and development and resolution of nonalcoholic fatty liver disease in nondiabetic individuals.
CONCLUSIONS: Increased glycemic levels within the nondiabetic range, as well as progression from NGR to T2D or prediabetes, were adversely associated with development and improvement of NAFLD. PMID: 32144419 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 7, 2020 Category: Endocrinology Authors: Wang B, Li M, Zhao Z, Wang S, Lu J, Chen Y, Xu M, Wang W, Ning G, Bi Y, Wang T, Xu Y Tags: J Clin Endocrinol Metab Source Type: research

Gender differences in the response to short-term cold exposure in young adults.
Abstract CONTEXT: Cold exposure (CE) has been shown to enhance energy expenditure by activating brown adipose tissue thermogenesis and metabolism in humans. However, it remains to be elucidated if there are gender-specific differences in cold-induced thermogenesis and metabolism. OBJECTIVE: To study the impact of mild CE on resting energy expenditure (REE) and metabolism in males compared to females. SETTING: A cross-sectional study. PARTICIPANTS: 117 healthy young Caucasians participated in this study (58 males). Mean age was 25.1 ± 3.6 years and mean BMI 22.3 ± 1.7 kg/m...
Source: The Journal of Clinical Endocrinology and Metabolism - March 7, 2020 Category: Endocrinology Authors: Mengel LA, Seidl H, Brandl B, Skurk T, Holzapfel C, Stecher L, Claussnitzer M, Hauner H Tags: J Clin Endocrinol Metab Source Type: research

Inherited missense mutation occurred Arginine76 of SRY gene not account for familial 46, XY sex reversal.
CONCLUSION:: In contrast to sporadic cases, inherited single nucleotide variations (SNVs) of SRY are not the main cause of the severe phenotype of 46,XY sex reversal, and the enhancers of SOX9 should be investigated carefully in such patients. PMID: 32140723 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 6, 2020 Category: Endocrinology Authors: Wang N, Zhu W, Han B, Wang H, Zhu H, Chen Y, Chen Y, Liu J, Liu Y, Zhao S, Song H, Qiao J Tags: J Clin Endocrinol Metab Source Type: research

Inflammation triggered by saturated fat ingestion is linked to insulin resistance and hyperandrogenism in PCOS.
CONCLUSION: In PCOS, increases in NFκB activation and circulating CRP and decreases in IκBα protein following saturated fat ingestion are independent of obesity. Circulating MNC and excess adipose tissue are separate and distinct contributors to inflammation in this disorder. PMID: 32140727 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 6, 2020 Category: Endocrinology Authors: González F, Considine RV, Abdelhadi OA, Acton AJ Tags: J Clin Endocrinol Metab Source Type: research

References for ultrasound staging of breast maturation, Tanner breast staging, pubic hair and menarche in Norwegian girls.
CONCLUSION: Thelarche occurred at a slightly younger age when assessed with ultrasound compared to clinical Tanner staging, although the two methods had a very good agreement when determining pubertal breast maturation. A significant decrease of 2.8 months in age at menarche was observed during the past decade in Norwegian girls. PMID: 32140730 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 6, 2020 Category: Endocrinology Authors: Bruserud IS, Roelants M, Oehme NHB, Madsen A, Eide GE, Bjerknes R, Rosendahl K, Juliusson PB Tags: J Clin Endocrinol Metab Source Type: research

Relationship of anabolic hormones with motor unit characteristics in quadriceps muscle in healthy and frail ageing men.
CONCLUSION: Our data highlight the associations between androgen levels and the electrophysiological characteristics of older men, particularly in the frail. Clinical trials involving administration of androgens will help to elucidate the potential benefits of intervention on neuromuscular function and/or frailty status. PMID: 32133493 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 5, 2020 Category: Endocrinology Authors: Swiecicka A, Piasecki M, Stashuk D, Jones D, Wu F, McPhee J, Rutter MK Tags: J Clin Endocrinol Metab Source Type: research

Accuracy of laboratory tests for the diagnosis of Cushing's syndrome.
CONCLUSIONS: All of the included diagnostic tests for CS are highly sensitive and specific. It appears that the DST is the most sensitive while the UFC is less sensitive. The specificity of all first-line tests appears comparable. PMID: 32133504 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 5, 2020 Category: Endocrinology Authors: Galm BP, Qiao N, Klibanski A, Biller BMK, Tritos NA Tags: J Clin Endocrinol Metab Source Type: research

Serum Angiopoietin-like Protein 6, Risk of Type 2 Diabetes, and Response to Hyperglycemia: A Prospective Cohort Study.
Abstract CONTEXT: Angiopoietin-like protein 6 (ANGPTL6) is a hepatokine that improves insulin sensitivity in animals. However, serum ANGPTL6 concentration was found to be higher in human subjects with diabetes or metabolic syndrome in cross-sectional studies, implying that ANGPTL6 may be induced to counteract hyperglycemia. OBJECTIVE: We investigated whether serum ANGPTL6 could predict incident diabetes and explored whether glucose or insulin could regulate ANGPTL6 expression and secretion. DESIGN: This cohort study included adults without diabetes at baseline, who were followed-up every two years for in...
Source: The Journal of Clinical Endocrinology and Metabolism - March 3, 2020 Category: Endocrinology Authors: Fan KC, Wu HT, Wei JN, Chuang LM, Hsu CY, Yen IW, Lin CH, Lin MS, Shih SR, Wang SH, Chang TJ, Li HY Tags: J Clin Endocrinol Metab Source Type: research

Hormonal profiles of menstrual bleeding patterns during the luteal-follicular transition.
CONCLUSIONS: Self-reported bleeding patterns may provide insight into luteal phase Pd3G levels. First bleed appears to be the best choice for defining the end of the luteal phase and achieving hormonal consistency across transitions. PMID: 32115635 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 2, 2020 Category: Endocrinology Authors: Jacobson MH, Howards PP, Kesner JS, Meadows JW, Dominguez CE, Spencer JB, Darrow LA, Terrell ML, Marcus M Tags: J Clin Endocrinol Metab Source Type: research

Differential frequency of CYP2R1 variants across populations reveals pathway selection for vitamin D homeostasis.
CONCLUSIONS: CYP2R1 polymorphisms have important effects on vitamin D homeostasis, and the geographic variability of CYP2R1 alleles represents an adaptation to differential exposures to UVB irradiation from sunlight. PMID: 32115644 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 2, 2020 Category: Endocrinology Authors: Casella A, Long C, Zhou J, Lai M, O'Lear L, Caplan I, Levine MA, Roizen JD Tags: J Clin Endocrinol Metab Source Type: research

Recharacterizing The Metabolic State of Energy Balance in Thrifty and Spendthrift Phenotypes.
Abstract PURPOSE: The human thrifty phenotype hypothesis presupposes that lower 24-hour energy expenditure (24EE) during famine preserves body mass and promotes survival. The prevailing view defines thrifty individuals as having a lower 24EE during fasting. However, it is also plausible that the greater decline in 24EE during fasting in thrifty individuals is due to higher 24EE during energy balance conditions (ENBAL). Herein, we provide evidence that this is indeed the case. METHODS: In 108 healthy subjects, 24EE was measured in a whole-room indirect calorimeter both during ENBAL and 24h fasting conditions. ...
Source: The Journal of Clinical Endocrinology and Metabolism - March 2, 2020 Category: Endocrinology Authors: Hollstein T, Basolo A, Ando T, Votruba SB, Walter M, Krakoff J, Piaggi P Tags: J Clin Endocrinol Metab Source Type: research

Resting energy expenditure in obese women with primary hypothyroidism and appropriate levothyroxine replacement therapy.
CONCLUSIONS: This study demonstrated that obese hypothyroid women in LT4 therapy with normal serum TSH level compared to euthyroid controls, are characterized by reduced REE, in line with the hypothesis that standard LT4 replacement therapy may not fully correct metabolic alterations related to hypothyroidism. We are not able to exclude that this feature may be influenced by the modulation of insulin sensitivity at the liver site, induced by LT4 oral administration. PMID: 32119074 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 2, 2020 Category: Endocrinology Authors: Muraca E, Ciardullo S, Oltolini A, Zerbini F, Bianconi E, Perra S, Villa M, Cannistraci R, Castoldi G, Pizzi P, Manzoni G, Lattuada G, Perseghin G Tags: J Clin Endocrinol Metab Source Type: research

Interleukin-6 (IL-6) activates the NOTCH1 signaling pathway through E-proteins in endometriotic lesions.
CONCLUSIONS: IL-6 induced NOTCH1 expression is mediated by E-proteins in the ectopic GE cells, which may promote endometriotic lesion development. PMID: 32119078 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 2, 2020 Category: Endocrinology Authors: Song Y, Su RW, Joshi NR, Kim TH, Lessey BA, Jeong JW, Fazleabas AT Tags: J Clin Endocrinol Metab Source Type: research

Serum Androgens are Independent Predictors of Insulin Clearance But Not of Insulin Secretion in Women With Pcos.
CONCLUSIONS: In women with PCOS metabolic clearance of insulin is reduced, contributing to generating hyperinsulinemia. Serum androgens are independent predictors of this phenomenon. PMID: 32119099 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 2, 2020 Category: Endocrinology Authors: Tosi F, Dal Molin F, Zamboni F, Saggiorato E, Salvagno GL, Fiers T, Kaufman JM, Bonora E, Moghetti P Tags: J Clin Endocrinol Metab Source Type: research

Maternal Glucocorticoid Metabolism Across Pregnancy: A Potential Mechanism Underlying Fetal Glucocorticoid Exposure.
Abstract CONTEXT: Across pregnancy, maternal serum cortisol levels increase up to 3-fold. It is not known whether maternal peripheral cortisol metabolism and clearance change across pregnancy or influence fetal cortisol exposure and development. OBJECTIVES: The primary study objective was to compare maternal urinary glucocorticoid metabolites, as markers of cortisol metabolism and clearance, between the second and third trimester of pregnancy. Secondary objectives were to test associations of total maternal urinary glucocorticoid excretion, with maternal serum cortisol levels and offspring birth weight z scor...
Source: The Journal of Clinical Endocrinology and Metabolism - March 1, 2020 Category: Endocrinology Authors: Stoye DQ, Andrew R, Grobman WA, Adam EK, Wadhwa PD, Buss C, Entringer S, Miller GE, Boardman JP, Seckl JR, Keenan-Devlin LS, Borders AEB, Reynolds RM Tags: J Clin Endocrinol Metab Source Type: research

Mapping the Steroid Response to Major Trauma From Injury to Recovery: A Prospective Cohort Study.
Abstract CONTEXT: Survival rates after severe injury are improving, but complication rates and outcomes are variable. OBJECTIVE: This cohort study addressed the lack of longitudinal data on the steroid response to major trauma and during recovery. DESIGN: We undertook a prospective, observational cohort study from time of injury to 6 months postinjury at a major UK trauma centre and a military rehabilitation unit, studying patients within 24 hours of major trauma (estimated New Injury Severity Score (NISS)> 15). MAIN OUTCOME MEASURES: We measured adrenal and gonadal steroids in serum and 24-hour ...
Source: The Journal of Clinical Endocrinology and Metabolism - February 27, 2020 Category: Endocrinology Authors: Foster MA, Taylor AE, Hill NE, Bentley C, Bishop J, Gilligan LC, Shaheen F, Bion JF, Fallowfield JL, Woods DR, Bancos I, Midwinter MM, Lord JM, Arlt W Tags: J Clin Endocrinol Metab Source Type: research

Clinical and Molecular Analysis in 2 Families With Novel Compound Heterozygous SBP2 (SECISBP2) Mutations.
CONCLUSIONS: We report 2 additional families with mutations in the SBP2 gene, a rare inherited condition manifesting global selenoprotein deficiencies. Report of additional families with SBP2 deficiency and their evaluation over time is needed to determine the full spectrum of clinical manifestations in SBP2 deficiency and increase our understanding of the role played by SBP2 and selenoproteins in health and disease. PMID: 32084277 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - February 23, 2020 Category: Endocrinology Authors: Fu J, Korwutthikulrangsri M, Gönç EN, Sillers L, Liao XH, Alikaşifoğlu A, Kandemir N, Menucci MB, Burman KD, Weiss RE, Dumitrescu AM Tags: J Clin Endocrinol Metab Source Type: research

Twice as High Diet-Induced Thermogenesis After Breakfast vs Dinner On High-Calorie as Well as Low-Calorie Meals.
Abstract BACKGROUND: The question of whether there is daytime time variation in diet-induced thermogenesis (DIT) has not been clearly answered. Moreover, it is unclear whether a potential diurnal variation in DIT is preserved during hypocaloric nutrition. OBJECTIVE: We hypothesized that DIT varies depending on the time of day and explored whether this physiological regulation is preserved after low-calorie compared with high-calorie intake. DESIGN: Under blinded conditions, 16 normal-weight men twice underwent a 3-day in-laboratory, randomized, crossover study. Volunteers consumed a predetermined low-cal...
Source: The Journal of Clinical Endocrinology and Metabolism - February 21, 2020 Category: Endocrinology Authors: Richter J, Herzog N, Janka S, Baumann T, Kistenmacher A, Oltmanns KM Tags: J Clin Endocrinol Metab Source Type: research

GIP and GLP-1 Receptor Antagonism During a Meal in Healthy Individuals.
CONCLUSIONS: Endogenous GIP and GLP-1 lower postprandial plasma glucose excursions and stimulate insulin secretion but only endogenous GIP affects gallbladder motility. The two incretin hormones potentiate each other's effects in the control of postprandial glycemia in healthy men. PMID: 32077470 [PubMed - in process] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - February 21, 2020 Category: Endocrinology Authors: Gasbjerg LS, Helsted MM, Hartmann B, Sparre-Ulrich AH, Veedfald S, Stensen S, Lanng AR, Bergmann NC, Christensen MB, Vilsbøll T, Holst JJ, Rosenkilde MM, Knop FK Tags: J Clin Endocrinol Metab Source Type: research