Letter to the Editor: "Cardiovascular Effects of Pioglitazone or Sulfonylureas According to Pretreatment Risk: Moving Toward Personalized Care".
Letter to the Editor: "Cardiovascular Effects of Pioglitazone or Sulfonylureas According to Pretreatment Risk: Moving Toward Personalized Care". J Clin Endocrinol Metab. 2020 Mar 01;105(3): Authors: de Carvalho LSF, Coelho OR, Sposito AC PMID: 32036386 [PubMed - in process] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - February 10, 2020 Category: Endocrinology Authors: de Carvalho LSF, Coelho OR, Sposito AC Tags: J Clin Endocrinol Metab Source Type: research

Response to Letter to the Editor: "Cardiovascular Effects of Pioglitazone or Sulfonylureas According to Pretreatment Risk: Moving Toward Personalized Care".
Response to Letter to the Editor: "Cardiovascular Effects of Pioglitazone or Sulfonylureas According to Pretreatment Risk: Moving Toward Personalized Care". J Clin Endocrinol Metab. 2020 Mar 01;105(3): Authors: Vaccaro O, Nicolucci A, Lucisano G, Masulli M, Riccardi G PMID: 32036387 [PubMed - in process] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - February 10, 2020 Category: Endocrinology Authors: Vaccaro O, Nicolucci A, Lucisano G, Masulli M, Riccardi G Tags: J Clin Endocrinol Metab Source Type: research

Insight into the Ontogeny of GnRH Neurons from Patients Born Without a Nose.
CONCLUSIONS: Patients with arhinia teach us that the GnRH neuron, a key gatekeeper of the reproductive axis, is associated with, but may not depend on, olfactory structures for normal migration and function, and more broadly, illustrate the power of extreme human phenotypes in answering fundamental questions about human embryology. PMID: 32034419 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - February 8, 2020 Category: Endocrinology Authors: Delaney A, Volochayev R, Meader B, Lee J, Almpani K, Noukelak GY, Henkind J, Chalmers L, Law JR, Williamson KA, Jacobsen CM, Buitrago TP, Perez O, Cho CH, Kaindl A, Rauch A, Steindl K, Garcia JE, Russell BE, Prasad R, Mondal UK, Reigstad HM, Clements S, K Tags: J Clin Endocrinol Metab Source Type: research

Rate and Extent of Recovery from Reproductive and Cardiac Dysfunction Due to Androgen Abuse in Men.
CONCLUSION: Suppressed testicular and cardiac function due to androgen abuse is effectively fully reversible (apart from testis volume and serum SHBG) with recovery taking between 6 to 18 months after ceasing androgen intake with possible cumulative effects on spermatogenesis. Suppressed serum AMH, LH and FSH represent convenient, useful and underutilized markers of recovery from androgen abuse. PMID: 32030409 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - February 7, 2020 Category: Endocrinology Authors: Shankara-Narayana N, Yu C, Savkovic S, Desai R, Fennell C, Turner L, Jayadev V, Conway AJ, Kockx M, Ridley L, Kritharides L, Handelsman DJ Tags: J Clin Endocrinol Metab Source Type: research

Distribution of body hair in young Australian women and associations with serum androgen concentrations.
Abstract CONTEXT: An important element of the diagnosis of polycystic ovary syndrome is hyperandrogenism. OBJECTIVE: To determine the distribution of modified Ferriman-Gallwey (mF-G) scores, as a measure of facial and body hair growth, and associations between the mF-G scores and serum androgen concentrations, including 11-oxygenated androgens. DESIGN: Cross-sectional study of non-health-care-seeking women, aged 18-39 years, recruited from the eastern states of Australia between November 2016 and July 2017. PARTICIPANTS AND MEASUREMENTS: Participants provided an mF-G self-assessment that corresponde...
Source: The Journal of Clinical Endocrinology and Metabolism - February 6, 2020 Category: Endocrinology Authors: Skiba MA, Bell RJ, Islam RM, Karim N, Davis SR Tags: J Clin Endocrinol Metab Source Type: research

Once-weekly somapacitan is effective and well tolerated in adults with GH deficiency: a randomized phase 3 trial.
CONCLUSIONS: In AGHD patients somapacitan administered once-weekly demonstrated superiority over placebo, and overall treatment effects and safety of somapacitan were in accordance with known effects and safety of GH replacement for up to 86 weeks of treatment. Somapacitan may provide an effective alternative to daily GH in AGHD. PMID: 32022863 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - February 5, 2020 Category: Endocrinology Authors: Johannsson G, Gordon MB, Rasmussen MH, Holme Håkonsson I, Karges W, Sværke C, Tahara S, Takano K, Biller BMK Tags: J Clin Endocrinol Metab Source Type: research

Mapping the Associations of the Plasma Lipidome with Insulin Resistance and Response to an Oral Glucose Tolerance Test.
CONCLUSIONS: The plasma lipidome and changes in lipid levels during an OGTT were associated with indices of insulin resistance. These findings underlie the involvement of molecular lipid species in the pathogenesis of insulin resistance and possibly crosstalk between insulin resistance and sex-specific regulation of lipid metabolism. PMID: 32016362 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - February 4, 2020 Category: Endocrinology Authors: Beyene HB, Hamley S, Giles C, Huynh K, Smith A, Cinel M, Mellet NA, Morales-Scholz MG, Kloosterman D, Howlett KF, Kowalski GM, Shaw CS, Magliano DJ, Bruce CR, Meikle PJ Tags: J Clin Endocrinol Metab Source Type: research

Serum Anti-M üllerian Hormone In The Prediction Of Response To hCG Stimulation In Children With DSD.
Serum Anti-Müllerian Hormone In The Prediction Of Response To hCG Stimulation In Children With DSD. J Clin Endocrinol Metab. 2020 Feb 04;: Authors: Lucas-Herald AK, Kyriakou A, Alimussina M, Guaragna-Filho G, Diver LA, McGowan R, Smith K, McNeilly JD, Ahmed SF Abstract INTRODUCTION: The relationship between serum anti-Müllerian hormone (AMH) and the testosterone response to hCG stimulation test is unclear. METHODS: Children who had hCG stimulation tests in one tertiary centre between 2001-2018 were included (n,138). Serum testosterone (T) was measured before (D1) and after 3 d...
Source: The Journal of Clinical Endocrinology and Metabolism - February 4, 2020 Category: Endocrinology Authors: Lucas-Herald AK, Kyriakou A, Alimussina M, Guaragna-Filho G, Diver LA, McGowan R, Smith K, McNeilly JD, Ahmed SF Tags: J Clin Endocrinol Metab Source Type: research

Ten years of very infrequent zoledronate therapy in older women: an open-label extension of a randomized trial.
CONCLUSIONS: These results suggest that zoledronate 5mg administered at a 5.5-year interval prevents bone loss over almost 11 years. Clinical trials to investigate whether very infrequent treatment with zoledronate reduces fracture risk are justified. PMID: 32016386 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - February 4, 2020 Category: Endocrinology Authors: Grey A, Horne A, Gamble G, Mihov B, Reid IR, Bolland M Tags: J Clin Endocrinol Metab Source Type: research

The Association between Heart Rate and Glycemic Status in the National Health and Nutrition Examination Surveys.
Abstract CONTEXT: Evidence suggests that heart rate (HR) is a prognostic factor for cardiovascular disease, for which persons with diabetes are at increased risk. OBJECTIVE: To determine the association between heart rate and glycemic status in a nationally representative sample of U.S. adults, and, among adults with diagnosed diabetes, the association between heart rate and A1c level. DESIGN: Cross-sectional study. SETTING: National Health and Nutrition Examination Surveys, 2011-2016. PARTICIPANTS: U.S. general adult (age ≥20 years) population who had information on glycemic status based on...
Source: The Journal of Clinical Endocrinology and Metabolism - February 4, 2020 Category: Endocrinology Authors: Casagrande SS, Cowie CC, Sosenko JM, Mizokami-Stout K, Boulton AJM, Pop-Busui R Tags: J Clin Endocrinol Metab Source Type: research

Circulating lysophosphatidylcholines in early pregnancy and risk of gestational diabetes in Chinese women.
This study aimed to explore associations of lysophosphatidylcholines (LPCs) in early pregnancy with gestational diabetes mellitus (GDM), and whether LPCs mediated the association of bile acids with GDM risk or had an interactive effect with bile acids on GDM risk. DESIGN: We conducted a 1:1 nested case-control study (n=486) from a large prospective pregnant women cohort in urban Tianjin, China. Blood samples were collected at their first antenatal care visit (median at 10th gestational weeks). LPCs were measured by liquid chromatography-tandem mass spectrometry analysis. Conditional binary logistic regression and rest...
Source: The Journal of Clinical Endocrinology and Metabolism - February 4, 2020 Category: Endocrinology Authors: Liu J, Li J, Li S, Leng J, Li W, Yang W, Huo X, Chen L, Ma RCW, Hu G, Fang Z, Yang X Tags: J Clin Endocrinol Metab Source Type: research

Long noncoding RNA HUPCOS promotes follicular fluid androgen excess in PCOS patients via aromatase inhibition.
CONCLUSIONS: Our findings suggested that HUPCOS mediated androgen excess in follicular fluid of PCOS patients by suppressing aromatase expression via interaction with RBPMS. PMID: 32016412 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - February 4, 2020 Category: Endocrinology Authors: Che Q, Liu M, Zhang D, Lu Y, Xu J, Lu X, Cao X, Liu Y, Dong X, Liu S Tags: J Clin Endocrinol Metab Source Type: research

Oxyntomodulin and glicentin may predict the effect of bariatric surgery on food preferences and weight loss.
n A Abstract BACKGROUND: Alterations in several gastrointestinal hormones are implicated in the postoperative suppression of food intake leading to weight loss after Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG). The aim was to evaluate changes in responses of gastrointestinal hormones after RYGB and SG and the associations of these changes with weight loss, energy intake, and food preferences. METHODS: Forty-two subjects with severe obesity were included (32 RYGB; 10 SG). Postprandial responses of glicentin, oxyntomodulin, GLP-1, PYY, and ghrelin were measured before and 6 months after surgery....
Source: The Journal of Clinical Endocrinology and Metabolism - February 4, 2020 Category: Endocrinology Authors: Nielsen MS, Ritz C, Wewer Albrechtsen NJ, Holst JJ, le Roux CW, Sjödin A Tags: J Clin Endocrinol Metab Source Type: research

AMH is higher across the menstrual cycle in early post-menarchal girls than in ovulatory women.
Abstract CONTEXT: Adolescents have more small, growing follicles and larger ovaries than normal women and are prone to anovulatory cycles (ANOV). It is unknown if a higher antral follicle count (AFC) per se contributes to ANOV in early post-menarchal girls. OBJECTIVE: To determine the relationship between AMH (an AFC biomarker), other reproductive hormones, and ANOV in post-menarchal girls and to compare AMH in girls and regularly cycling adults. METHODS: 23 girls (1.7 ± 0.2 yrs post-menarche) and 32 historic adult controls (
Source: The Journal of Clinical Endocrinology and Metabolism - February 4, 2020 Category: Endocrinology Authors: Ortega MT, Carlson L, McGrath JA, Kangarloo T, Adams JM, Sluss PM, Lambert-Messerlian G, Shaw ND Tags: J Clin Endocrinol Metab Source Type: research

Functional analyses of HNF1A-MODY variants refine the interpretation of identified sequence variants.
sh;rkhaug L Abstract CONTEXT: While rare variants of the hepatocyte nuclear factor-1 alpha (HNF1A) gene can cause Maturity-onset diabetes of the young (HNF1A-MODY), other variants can be risk factors for the development of type 2 diabetes. As has been suggested by the American College of Medical Genetics (ACMG) guidelines for variant interpretation, functional studies provide strong evidence to classify a variant as pathogenic. OBJECTIVE: We hypothesized that a functional evaluation can improve the interpretation of the HNF1A variants in our Czech MODY Registry. DESIGN, SETTINGS AND PARTICIPANTS: We stud...
Source: The Journal of Clinical Endocrinology and Metabolism - February 4, 2020 Category: Endocrinology Authors: Malikova J, Kaci A, Dusatkova P, Aukrust I, Torsvik J, Vesela K, Kankova PD, Njølstad PR, Pruhova S, Bjørkhaug L Tags: J Clin Endocrinol Metab Source Type: research

Direct Oral Anticoagulants in Atrial Fibrillation Patients with Concomitant Hyperthyroidism.
CONCLUSION: Among NVAF Asian patients with concomitant hyperthyroidism, DOACs may be an effective and safer alternative to warfarin. Thromboprophylaxis with DOACs may be considered for such patients, and it is important to validate this finding in further prospective study. PMID: 32009154 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - February 3, 2020 Category: Endocrinology Authors: Chan YH, Wu LS, See LC, Liu JR, Chang SH, Chao TF, Yeh YH, Kuo CT, Lee HF, Lip GYH Tags: J Clin Endocrinol Metab Source Type: research

Longitudinal Changes in the Relationship Between Hemoglobin A1c and Glucose Tolerance Across Pregnancy and Postpartum.
Abstract OBJECTIVE: To characterize the relationship between hemoglobin A1c (HbA1c) levels and glucose tolerance across pregnancy and postpartum. DESIGN AND PARTICIPANTS: In a longitudinal study of pregnant women with gestational diabetes risk factors (N=102), we performed oral glucose tolerance testing (OGTT) and HbA1c measurements at 10-15 weeks gestation, 24-30 weeks gestation (N=73), and 6-24 weeks postpartum (N=42). Complete blood counts were obtained from clinical records. We calculated HbA1c-estimated average glucose levels and compared them with mean OGTT glucose levels (average of fasting, 1- and 2-h...
Source: The Journal of Clinical Endocrinology and Metabolism - February 3, 2020 Category: Endocrinology Authors: Edelson PK, James KE, Leong A, Arenas J, Cayford M, Callahan MJ, Bernstein SN, Tangren JS, Hivert MF, Higgins JM, Nathan DM, Powe CE Tags: J Clin Endocrinol Metab Source Type: research

Metabolic and Genetic Determinants of Glucose Shape After Oral Challenge in Obese Youths: A Longitudinal Study.
rio S Abstract CONTEXT: The time-to-glucose-peak following the oral glucose tolerance test (OGTT) is a highly reproducible marker for diabetes risk. In obese youths, we lack evidence for the mechanisms underlying the effects of the TCF7L2 rs7903146 variant on glucose peak. METHODS: We analyzed the metabolic phenotype and the genotype for the TCF7L2 rs7903146 in 630 obese youths with normal (NGT) and impaired (IGT) glucose tolerance. Participants underwent a 3-hour, 9-point OGTT to estimate, using the oral minimal model, the disposition index (DI), the static (φstatic) and dynamic (φdynamic) components...
Source: The Journal of Clinical Endocrinology and Metabolism - January 25, 2020 Category: Endocrinology Authors: Galderisi A, Tricò D, Dalla Man C, Santoro N, Pierpont B, Groop L, Cobelli C, Caprio S Tags: J Clin Endocrinol Metab Source Type: research

Effect of chronic pancreatitis on complications and mortality in DM patients: A 10-year nationwide cohort study.
Abstract CONTEXT: Chronic pancreatitis (CP), is a long-term inflammation of the pancreatic parenchyma, might increase risk of a hyperglycemia crisis or hypoglycemia in patients with diabetes mellitus (DM), but the relationship has not been previously investigated. OBJECTIVE: To investigate the risk of diabetic ketoacidosis (DKA), hyperglycemic hyperosmolar state (HHS), hypoglycemia, and long-term outcomes in DM patients with CP. DESIGN: A population-based cohort study. SETTING AND PARTICIPANTS: Tapping Taiwan`s National Health Insurance Research Database, we identified 506 DM patients with newly dia...
Source: The Journal of Clinical Endocrinology and Metabolism - January 24, 2020 Category: Endocrinology Authors: Lin CH, Yeh NC, Wang JJ, Ho CH, Her SH, Tsay WI, Chien CC Tags: J Clin Endocrinol Metab Source Type: research

HLA class II allele analyses implicate common genetic components in type 1 and non-insulin treated type 2 diabetes.
CONCLUSIONS: Genetic variation in the HLA class II locus exerts risk and protective effects on non-insulin treated type 2 diabetes. Our data suggest that the genetic architecture of type 1 diabetes and type 2 diabetes might share common components on the HLA class II locus. PMID: 31974565 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - January 24, 2020 Category: Endocrinology Authors: Jacobi T, Massier L, Klöting N, Horn K, Schuch A, Ahnert P, Engel C, Löffler M, Burkhardt R, Thiery J, Tönjes A, Stumvoll M, Blüher M, Doxiadis I, Scholz M, Kovacs P Tags: J Clin Endocrinol Metab Source Type: research

Response to Letter to the Editor: "Body composition and markers of cardiometabolic health in transgender youth compared to cisgender youth".
Response to Letter to the Editor: "Body composition and markers of cardiometabolic health in transgender youth compared to cisgender youth". J Clin Endocrinol Metab. 2020 Jan 24;: Authors: Nokoff N PMID: 31974575 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - January 24, 2020 Category: Endocrinology Authors: Nokoff N Tags: J Clin Endocrinol Metab Source Type: research

Daily Oral Administration of the Novel Androgen 11 β-MNTDC Markedly Suppresses Serum Gonadotropins In Healthy Men.
Daily Oral Administration of the Novel Androgen 11β-MNTDC Markedly Suppresses Serum Gonadotropins In Healthy Men. J Clin Endocrinol Metab. 2020 Jan 24;: Authors: Yuen F, Thirumalai A, Pham C, Swerdloff RS, Anawalt BD, Liu PY, Amory JK, Bremner WJ, Dart C, Wu H, Hull L, Blithe DL, Long J, Wang C, Page ST Abstract BACKGROUND: 11β-methyl-19-nortestosterone (11β-MNT) is a modified testosterone (T) with androgenic and progestational activity. A single oral dose of the prodrug, 11β-MNT dodecylcarbonate (11β-MNTDC), was well-tolerated in healthy men. METHODS: We conducted a rand...
Source: The Journal of Clinical Endocrinology and Metabolism - January 24, 2020 Category: Endocrinology Authors: Yuen F, Thirumalai A, Pham C, Swerdloff RS, Anawalt BD, Liu PY, Amory JK, Bremner WJ, Dart C, Wu H, Hull L, Blithe DL, Long J, Wang C, Page ST Tags: J Clin Endocrinol Metab Source Type: research

Relationship of body mass index and waist circumference with risk of new-onset proteinuria in hypertensive patients.
CONCLUSION: In Chinese hypertensive patients, increased BMI and increased WC were individually and jointly associated with a higher risk of new-onset proteinuria, underscoring the value of monitoring both BMI and waist circumference in assessing proteinuria risk. PMID: 31976527 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - January 24, 2020 Category: Endocrinology Authors: Liu M, Zhang Z, Zhou C, He P, Nie J, Liang M, Liu C, Xu F, Liao G, Zhang Y, Li J, Wang B, Wang X, Huo Y, Xu X, Qin X Tags: J Clin Endocrinol Metab Source Type: research

Population-based data at ages 31 and 46 show decreased HRQoL and life satisfaction in women with PCOS symptoms.
CONCLUSIONS: Women with PCOS present with low HRQoL, decreased life satisfaction, and a poorer self-reported health status up to their late reproductive years. Assessments and interventions aiming to improve HRQoL in PCOS should be targeted beyond fertile age. PMID: 31970392 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - January 23, 2020 Category: Endocrinology Authors: Karjula S, Morin-Papunen L, Franks S, Auvinen J, Järvelin MR, Tapanainen JS, Jokelainen J, Miettunen J, Piltonen TT Tags: J Clin Endocrinol Metab Source Type: research

Circadian misalignment of the 24-hr profile of endocannabinoid 2-arachidonoylglycerol (2-AG) in obese adults.
CONCLUSIONS: Obesity appears to be associated with a dampening and delay of the 24-hr variation of eCB activity relative to the central circadian signal as well as to the daily leptin rhythm. This misalignment may play a role in the pathophysiology of obesity. PMID: 31970413 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - January 23, 2020 Category: Endocrinology Authors: Hanlon EC, Leproult R, Stuhr KL, Doncheck EM, Hillard CJ, Van Cauter E Tags: J Clin Endocrinol Metab Source Type: research

Obese adolescents with PCOS have altered biodiversity and relative abundance in gastrointestinal microbiota.
Abstract CONTEXT: Alterations in gut microbiota relate to the metabolic syndrome, but have not been examined in at-risk obese youth with polycystic ovary syndrome (PCOS). OBJECTIVE: Compare the composition and diversity of the gut microbiota and associations with metabolic and hormonal measures between two equally obese groups of girls with or without PCOS. DESIGN: Prospective, case-control cross-sectional study. SETTING: Tertiary-care center. PARTICIPANTS: Fifty-eight obese female adolescents (PCOS N=37, 16.1±0.3 years, BMI 98.5%ile; non-PCOS N=21, 14.5±0.4 years, BMI 98.7%ile). ...
Source: The Journal of Clinical Endocrinology and Metabolism - January 23, 2020 Category: Endocrinology Authors: Jobira B, Frank DN, Pyle L, Silveira LJ, Kelsey MM, Garcia-Reyes Y, Robertson CE, Ir D, Nadeau KJ, Cree-Green M Tags: J Clin Endocrinol Metab Source Type: research

AMH as a predictor of the final menstrual period.
PMID: 31970419 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - January 23, 2020 Category: Endocrinology Authors: Steiner AZ Tags: J Clin Endocrinol Metab Source Type: research

An activating variant in CTNNB1 is associated with a sclerosing bone dysplasia and adrenocortical neoplasia.
CONCLUSION: Increased β-catenin activity associated with a de novo gain-of-function CTNNB1 variant is associated with osteosclerotic phenotype and adrenocortical neoplasia. PMID: 31970420 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - January 23, 2020 Category: Endocrinology Authors: Peng H, Jenkins ZA, White R, Connors S, Hunter MF, Ronan A, Zankl A, Markie DM, Daniel PB, Robertson SP Tags: J Clin Endocrinol Metab Source Type: research

Letter to the Editor: "Body composition and markers of cardiometabolic health in transgender youth compared to cisgender youth."
Letter to the Editor: "Body composition and markers of cardiometabolic health in transgender youth compared to cisgender youth." J Clin Endocrinol Metab. 2020 Jan 22;: Authors: Sacerdote A PMID: 31965152 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - January 22, 2020 Category: Endocrinology Authors: Sacerdote A Tags: J Clin Endocrinol Metab Source Type: research

Implications of the Hemoglobin Glycation Index on the Diagnosis of Prediabetes and Diabetes.
CONCLUSIONS: High HGI was associated with Black race and female sex as reported previously. The observation that 2hPG was not different across HGI subgroups suggests that variation in postprandial glucose is not a significant source of population variation in HGI. Exclusive use of HbA1c for diagnosis will classify more Blacks and women as having prediabetes compared to using FPG or 2hPG. PMID: 31965161 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - January 22, 2020 Category: Endocrinology Authors: Hsia DS, Rasouli N, Pittas AG, Lary CW, Peters A, Lewis MR, Kashyap SR, Johnson KC, LeBlanc ES, Phillips LS, Hempe JM, Desouza CV, D2d Research Group Tags: J Clin Endocrinol Metab Source Type: research

Is Better Sleep Beneficial for Metabolic Outcomes in Obese Female Adolescents with Polycystic Ovarian Syndrome?
PMID: 31965168 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - January 22, 2020 Category: Endocrinology Authors: Mehra R, Kashyap SR, Shah V Tags: J Clin Endocrinol Metab Source Type: research

Anti-Mullerian Hormone and Impending Menopause in Late Reproductive Age: The Study of Women's Health Across the Nation.
Abstract BACKGROUND: A test that helps predict the time to the final menstrual period (FMP) has been sought for many years. OBJECTIVE: To assess the ability of Anti-Mullerian Hormone (AMH) measurements to predictions the time to FMP. DESIGN: Prospective longitudinal cohort study. SETTING: The Study of Women's Health Across the Nation. PARTICIPANTS AND MEASUREMENTS: AMH and FSH were measured in 1537 pre- or early perimenopausal women, mean age 47.5 ± 2.6 years at baseline, then serially until 12 months of amenorrhea occurred. AMH was measured using a two-site ELISA with a detection limit ...
Source: The Journal of Clinical Endocrinology and Metabolism - January 22, 2020 Category: Endocrinology Authors: Finkelstein JS, Lee H, Karlamangla A, Neer RM, Sluss PM, Burnett-Bowie SM, Darakananda K, Donahoe PK, Harlow SD, Prizand SH, Joffe H, Kumar A, Martin DE, McConnell D, Merrilat S, Morrison A, Pastore LM, Randolph JF, Greendale GA, Santoro N Tags: J Clin Endocrinol Metab Source Type: research

Impact of transition in metabolic health and obesity on the incident chronic kidney disease: A nationwide cohort study.
CONCLUSIONS: MHO was a dynamic condition, and people with MHO constituted a heterogeneous group. Although the MHO phenotype was generally associated with incident CKD, maintenance of metabolic health and weight reduction might alleviate the risk of CKD. PMID: 31967306 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - January 22, 2020 Category: Endocrinology Authors: Cho YK, Lee J, Kim HS, Park JY, Lee WJ, Kim YJ, Jung CH Tags: J Clin Endocrinol Metab Source Type: research

Infertility, gravidity, and risk of diabetes among high-risk women in the Diabetes Prevention Program Outcomes Study.
CONCLUSIONS: Pregnancy, particularly combined with a history of infertility, confers increased risk of diabetes but not CAC among glucose-intolerant premenopausal women. PMID: 31955207 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - January 19, 2020 Category: Endocrinology Authors: Kim C, Younes N, Temprosa M, Edelstein S, Goldberg RB, Araneta MG, Wallia A, Brown A, Darwin C, Ibebuogu U, Pi-Sunyer X, Knowler WC, Diabetes Prevention Program Research Group Tags: J Clin Endocrinol Metab Source Type: research

Gamma-glutamyl transferase variability and risk of dementia in diabetes mellitus: a nationwide population-based study.
Abstract CONTEXT: Gamma-glutamyl transferase (GGT) has been associated with oxidative stress and inflammatory reactions. Variability in various biomarkers has emerged as a new clinical indicator for diseases including neurodegenerative disorders. OBJECTIVE: We investigated the association between GGT variability and dementia risk in patients with diabetes mellitus (DM). DESIGN, PARTICIPANTS, AND METHODS: We used the Korean National Health Insurance Service datasets of Claims and Health Check-ups from 2004 to 2016. The risk of incident dementia (all-cause dementia, Alzheimer disease, vascular dementia) wa...
Source: The Journal of Clinical Endocrinology and Metabolism - January 19, 2020 Category: Endocrinology Authors: Hong SH, Han K, Park S, Kim SM, Kim NH, Choi KM, Baik SH, Park YG, Yoo HJ Tags: J Clin Endocrinol Metab Source Type: research

Risk Factors for Cardiovascular Disease (CVD) in Adults with Type 1 Diabetes: Findings from Prospective Real-life T1D Exchange Registry.
CONCLUSION: HbA1c, hypertension, dyslipidemia and diabetic nephropathy are important risk factors for CVD in adults with type 1 diabetes. A longer follow-up is likely required to assess the impact of other traditional CVD risk factors on incident CVD in the current era. PMID: 31955209 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - January 19, 2020 Category: Endocrinology Authors: Shah VN, Bailey R, Wu M, Foster NC, Pop-Busui R, Katz M, Crandall J, Bacha F, Nadeau K, Libman I, Hiers P, Mizokami-Stout K, DiMeglio LA, Sherr J, Pratley R, Agarwal S, Snell-Bergeon J, Cengiz E, Polsky S, Mehta SN, T1D Exchange Registry Tags: J Clin Endocrinol Metab Source Type: research

Gestational diabetes risk in migrants. A nation-wide register-based study of all births in Denmark 2004-2015.
Abstract BACKGROUND: Much remains to be understood about socio-economic position and body mass index (BMI) in the pathways linking ethnicity, migration and gestational diabetes mellitus (GDM). We investigated differences in GDM prevalence according to maternal country of origin and the role played by socio-economic position and BMI on this relation. Finally, we examined how length of residency was associated with GDM. METHODS: A register-based cohort study of the 725482 pregnancies that resulted in a birth in Denmark, 2004-2015. Of these, 14.4% were by women who had migrated to Denmark. A GDM diagnosis was re...
Source: The Journal of Clinical Endocrinology and Metabolism - January 17, 2020 Category: Endocrinology Authors: Kragelund Nielsen K, Andersen GS, Damm P, Andersen AN Tags: J Clin Endocrinol Metab Source Type: research

Revisiting classical 3 β-hydroxysteroid dehydrogenase 2 deficiency: lessons from 31 pediatric cases.
CONCLUSIONS: Genetically documented 3βHSD2 deficiency includes salt-losing and non-salt-losing clinical phenotypes. Spared mineralocorticoid function and unvirilized genitalia in females may lead to misdiagnosis and underestimation of the frequency of 3βHSD2 deficiency. High baseline 17OHPreg to cortisol ratio and low 11-oxyandrogen concentrations by LC-MS/MS unequivocally identifies patients with 3βHSD2 deficiency. PMID: 31950145 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - January 17, 2020 Category: Endocrinology Authors: Guran T, Kara C, Yildiz M, Bitkin EC, Haklar G, Lin JC, Keskin M, Barnard L, Anik A, Catli G, Guven A, Kirel B, Tutunculer F, Onal H, Turan S, Akcay T, Atay Z, Yilmaz GC, Mamadova J, Akbarzade A, Sirikci O, Storbeck KH, Baris T, Chung BC, Bereket A Tags: J Clin Endocrinol Metab Source Type: research

Brain Differences in the Prefrontal Cortex, Amygdala, and Hippocampus in Youth with Congenital Adrenal Hyperplasia.
CONCLUSIONS: This study replicates previous findings of smaller medial temporal lobe volumes in CAH patients, and suggests that lateral nucleus of the amygdala, as well as subiculum and subfield CA1 of the hippocampus are particularly affected within the medial temporal lobes in CAH youth. PMID: 31950148 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - January 17, 2020 Category: Endocrinology Authors: Herting MM, Azad A, Kim R, Tyszka JM, Geffner ME, Kim MS Tags: J Clin Endocrinol Metab Source Type: research

Association of prediabetes with CKD progression and adverse cardiovascular outcomes: an analysis of the CRIC study.
CONCLUSIONS: In individuals with CKD, prediabetes was not associated with composite renal outcome, but was associated with an increased risk of proteinuria progression and adverse CV outcomes. PMID: 31943096 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - January 16, 2020 Category: Endocrinology Authors: Neves JS, Correa S, Baeta Baptista R, Bigotte Vieira M, Waikar SS, Mc Causland FR Tags: J Clin Endocrinol Metab Source Type: research

High performance chromatography-mass spectrometry (HPLC-MS) Based Lipid Metabolite Profiling of Acromegaly.
CONCLUSION: Patients with acromegaly have distinct lipid metabolite profiling while PE (22:6/16:0) and LysoPC (16:0) are correlated with cardiac structure and function, which may contribute to the risk of cardiovascular complications. PMID: 31930294 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - January 13, 2020 Category: Endocrinology Authors: Wang M, Guo S, He M, Shao X, Feng L, Yu Y, Gong W, Liu Q, Melnikov V, Wang X, He Z, Jiang L, Chen M, Sun J, Cai J, Zhao Y, Li Y, Tritos NA, Hu Z, Zhang Z Tags: J Clin Endocrinol Metab Source Type: research

Cognitive function of children and adolescents with congenital adrenal hyperplasia: importance of early diagnosis.
CONCLUSION: Children and adolescents with CAH who were diagnosed early via a neonatal screening program and treated with hydrocortisone had normal psychometric intelligence and executive functions. PMID: 31927590 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - January 12, 2020 Category: Endocrinology Authors: Messina V, Karlsson L, Hirvikoski T, Nordenström A, Lajic S Tags: J Clin Endocrinol Metab Source Type: research

The relationship of gastrinoma in MEN 1 to Helicobacter Pylori infection.
CONCLUSION: Past H. pylori exposure was associated with increased prevalence and severity of hypergastrinaemia in MEN 1 patients. Past H. pylori-related hypergastrinaemia may contribute to the pathogenesis of ongoing gastrin hypersecretion by susceptible foregut neuroendocrine tissues. PMID: 31919513 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - January 10, 2020 Category: Endocrinology Authors: Endall R, Thompson M, Parameswaran V, Burgess J Tags: J Clin Endocrinol Metab Source Type: research

Which Drug Next? Sequential Therapy for Osteoporosis.
Abstract The proliferation of drugs with unique modes of action for treating osteoporosis has been most welcome. Fear of complications , even though rare, associated with long term bisphosphonates, changed prescribing patterns. The Bisphosphonates are stored in bone for years. Drugs not stored in bone; e.g. abaloparatide, teriparatide, denosumab, and romosozumab have expanded our armamentarium for treating osteoporosis but have brought new challenges. Bone accrued during treatment with the latter 3 drugs, and perhaps abaloparatide, is lost rapidly after their withdrawl due to rebound increase in bone resorption. T...
Source: The Journal of Clinical Endocrinology and Metabolism - January 10, 2020 Category: Endocrinology Authors: Lukert BP Tags: J Clin Endocrinol Metab Source Type: research

Changes in thyroid function across adolescence: a longitudinal study.
Abstract OBJECTIVE: There are no large, longitudinal studies of thyroid function across adolescence. The aims of this study were to examine longitudinal trends in TSH, fT3 and fT4 and determine age-specific reference ranges. METHODS: Thyroid function was assessed in 3415 participants in the Brisbane Longitudinal Twin Study at age 12, 14 and 16, using the Abbott ARCHITECT immunoassay. Longitudinal analyses were adjusted for body mass index and puberty. RESULTS: In girls, mean fT4 (± SE) increased between age 12 and 14 (by 0.30 ± 0.08 pmol/L, P
Source: The Journal of Clinical Endocrinology and Metabolism - January 10, 2020 Category: Endocrinology Authors: Campbell PJ, Brown SJ, Kendrew P, Lewer M, Lim EM, Joseph J, Cross SM, Wright MJ, Martin NG, Wilson SG, Walsh JP Tags: J Clin Endocrinol Metab Source Type: research

A polygenic risk score suggests shared genetic architecture of voice break with early markers of pubertal onset in boys.
CONCLUSIONS: Genetic variants identified in large GWAS on age at VB significantly associate with age at testicular growth and pubic hair development suggesting that these events share a genetic architecture across ethnically distinct populations. PMID: 31915828 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - January 9, 2020 Category: Endocrinology Authors: Lardone MC, Busch AS, Santos JL, Miranda P, Eyheramendy S, Pereira A, Juul A, Almstrup K, Mericq V Tags: J Clin Endocrinol Metab Source Type: research

Bariatric Surgery vs. Lifestyle Intervention for Diabetes Treatment: Five Year Outcomes From a Randomized Trial.
Abstract CONTEXT: Questions remain about bariatric surgery for type 2 diabetes mellitus (T2DM) treatment. OBJECTIVE: Compare the remission of T2DM following surgical or non-surgical treatments. DESIGN, SETTING, AND PARTICIPANTS: Randomized Controlled Trial at the University of Pittsburgh, in the United States. Five year follow up from February 2015 until June 2016. INTERVENTIONS: 61 participants with obesity and T2DM who were initially randomized to either bariatric surgical treatments (Roux-en-Y gastric bypass [RYGB] or laparoscopic adjustable gastric banding [LAGB]) or an intensive lifestyle weigh...
Source: The Journal of Clinical Endocrinology and Metabolism - January 9, 2020 Category: Endocrinology Authors: Courcoulas AP, Gallagher JW, Neiberg RH, Eagleton EB, DeLany JP, Lang W, Punchai S, Gourash W, Jakicic JM Tags: J Clin Endocrinol Metab Source Type: research

Polycystic ovary syndrome signs and metabolic syndrome in premenopausal Hispanic/Latina women: The HCHS/SOL study.
CONCLUSIONS: In Hispanic/Latina women, irregular menstrual cycles, self-reported PCOS, and any PCOS sign were associated with MetS and could indicate women at metabolic disease risk. PMID: 31917455 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - January 9, 2020 Category: Endocrinology Authors: Meyer ML, Sotres-Alvarez D, Steiner AZ, Cousins L, Talavera GA, Cai J, Daviglus ML, Loehr LR Tags: J Clin Endocrinol Metab Source Type: research

A polygenic and phenotypic risk prediction for Polycystic Ovary Syndrome evaluated by Phenome-wide association studies.
CONCLUSIONS: Our study has expanded the methodological utility of PRS in patient stratification and risk prediction, especially in a multifactorial condition like PCOS, across different genetic origins. By utilizing the individual genome-phenome data available from the EHR, our approach also demonstrates that polygenic prediction by PRS can provide valuable opportunities to discover the pleiotropic phenomic network associated with PCOS pathogenesis. PMID: 31917831 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - January 9, 2020 Category: Endocrinology Authors: Joo YY, Actkins K, Pacheco JA, Basile AO, Carroll R, Crosslin DR, Day F, Denny JC, Velez Edwards DR, Hakonarson H, Harley JB, Hebbring SJ, Ho K, Jarvik GP, Jones M, Karderi T, Mentch FD, Meun C, Namjou B, Pendergrass S, Ritchie MD, Stanaway IB, Urbanek M, Tags: J Clin Endocrinol Metab Source Type: research

Once-weekly somapacitan versus daily GH in children with GH deficiency: Results from a randomized phase 2 trial.
CONCLUSIONS: In children with GHD, once-weekly somapacitan 0.16mg/kg/week provided the closest efficacy match with similar safety and tolerability to daily GH after 26 and 52 weeks of treatment. PMID: 31917835 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - January 9, 2020 Category: Endocrinology Authors: Sävendahl L, Battelino T, Brod M, Rasmussen MH, Horikawa R, Juul RV, Saenger P Tags: J Clin Endocrinol Metab Source Type: research