The Journal of Clinical Endocrinology and Metabolism This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

The Race for New Treatments for Graves Orbitopathy (Thyroid Eye Disease)
J Clin Endocrinol Metab. 2024 Mar 7:dgad693. doi: 10.1210/clinem/dgad693. Online ahead of print.NO ABSTRACTPMID:38451776 | DOI:10.1210/clinem/dgad693 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 7, 2024 Category: Endocrinology Authors: Colin M Dayan Source Type: research

The Interactive Effects of Sedentary Time, Physical Activity, and Fat Mass on Insulin Resistance in the Young Population
CONCLUSIONS: Promoting LPA while decreasing body fat mass and ST may be considered crucial intervention targets to attenuate the risk of hyperinsulinemia and insulin resistance from childhood through young adulthood.PMID:38441224 | DOI:10.1210/clinem/dgae135 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 5, 2024 Category: Endocrinology Authors: Andrew O Agbaje Source Type: research

Impact of impaired awareness of hypoglycemia on glucose decline during and after exercise in T1D: The T1DEXI Study
CONCLUSION: Individuals with IAH have a higher underlying risk of hypoglycemia than 'Aware' individuals. Exercise does not appear to differentially increase risk for hypoglycemia during the activity, or in the subsequent 24-hours for IAH compared to Aware individuals with T1D.PMID:38441232 | DOI:10.1210/clinem/dgae115 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 5, 2024 Category: Endocrinology Authors: Jorge L Jo Kamimoto Zoey Li Robin L Gal Jessica R Castle Francis J Doyle Peter G Jacobs Corby K Martin Roy W Beck Peter Calhoun Michael C Riddell Michael R Rickels Source Type: research

Analytical Validation of a Telomerase Reverse Transcriptase (TERT) Promoter Mutation Assay
CONCLUSION: The analytical robustness and reproducibility of the Afirma TERT test support its routine clinical use among thyroid nodules with indeterminate cytology that are Afirma GSC suspicious or among Bethesda V/VI nodules.PMID:38441247 | DOI:10.1210/clinem/dgae134 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 5, 2024 Category: Endocrinology Authors: Priyanka C Iyer Ramona Dadu Anna Barque Cleslei Zanelli Xingyu Zheng Huimin Jiang P Sean Walsh Yangyang Hao Jing Huang Joshua Klopper Richard T Kloos Maria Cabanillas Source Type: research

Young onset type2 diabetes: when gluconeogenesis is overfueled and out of control
J Clin Endocrinol Metab. 2024 Mar 5:dgae123. doi: 10.1210/clinem/dgae123. Online ahead of print.NO ABSTRACTPMID:38441504 | DOI:10.1210/clinem/dgae123 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 5, 2024 Category: Endocrinology Authors: Francois Alhenc-Gelas Michel Marre Source Type: research

Pediatric Medullary Thyroid Carcinoma: Clinical Presentations and Long-term Outcomes in 144 Patients Over Six Decades
CONCLUSIONS: sMTC is primarily a RET-driven disease that represents 14% of childhood-onset MTC in this cohort. Pediatric sMTC patients are older, present with clinical disease at a more advanced TNM classification, and have more persistent disease at last follow up compared with hMTC, but these differences disappear when comparing those presenting clinically. Somatic molecular testing should be considered in sMTC patients who would benefit from systemic therapy.PMID:38441533 | DOI:10.1210/clinem/dgae133 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 5, 2024 Category: Endocrinology Authors: Sarah G Hensley Mimi I Hu Roland L Bassett Anita K Ying Mark E Zafereo Nancy D Perrier Naifa L Busaidy Samuel M Hyde Elizabeth G Grubbs Steven G Waguespack Source Type: research

Revisiting the Effect of Leptin on Alzheimer's Disease and Parkinson's Disease: the Role of Insulin Sensitivity
CONCLUSION: The study offers evidence supporting a potential protective effect of leptin in AD, but not PD, via the enhancement of insulin sensitivity. Our findings underscore the distinct roles of leptin in AD and PD.PMID:38441543 | DOI:10.1210/clinem/dgae136 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 5, 2024 Category: Endocrinology Authors: Xingzhi Guo Peng Tang Xin Zhang Rui Li Source Type: research

Characterization of novel PHEX variants in X-linked hypophosphatemic rickets and genotype-PHEX activity correlation
CONCLUSION: Therefore, our findings demonstrated that novel PHEX variants could disrupt protein function via affecting protein synthesis, post-translational modification, cellular trafficking and catalytic activity. Our study facilitates a better understanding of XLHR pathogenic mechanism and PHEX activity-phenotype correlation, which is of crucial importance for future diagnosis and treatment of XLHR.PMID:38442738 | DOI:10.1210/clinem/dgae120 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 5, 2024 Category: Endocrinology Authors: Huixiao Wu Hui Ying Wanyi Zhao Yan Sun Yanzhou Wang Xinyu Chen Guimei Li Yangyang Yao Shuo Xu Tianyou Li Li Fang Xiaoqing Sun Ning Wang Jin Xu Qingbo Guan Weibo Xia Li Wang Ling Gao Jiajun Zhao Chao Xu Source Type: research

Development and external validation of a home-based risk predicTion modEl of natUral onseT of menopAuse -TEUTA
CONCLUSIONS: We present the first internally and externally validated prediction model of natural menopause onset using readily available predictors. Validation of our model to other populations is needed.PMID:38442740 | DOI:10.1210/clinem/dgae125 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 5, 2024 Category: Endocrinology Authors: Lum Kastrati Pedro Marques Vidal Klodian Dhana Lia Bally Irene Lambrinoudaki Dion Groothof Stephan J L Bakker Michele F Eisenga Taulant Muka Source Type: research

Contralateral suppression in adrenal venous sampling predicts clinical and biochemical outcome in primary aldosteronism
CONCLUSION: A CS >50% was an independent predictor of complete clinical and biochemical cure. Moreover, it can predict unilateral PA and postoperative biochemical hypoaldosteronism. Our findings underscore the usefulness of CS for clinical decision-making.PMID:38442744 | DOI:10.1210/clinem/dgae142 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 5, 2024 Category: Endocrinology Authors: Jessica Okubo Paula Frudit Aline C B S Cavalcante Ana A W Maciel Thais C Freitas Bruna Pilan Gustavo F C Fagundes Nara L Queiroz Matheo A M Stumpf Victor C M Souza Eduardo Z Kawahara Tatiana S Goldbaum Maria Adelaide A Pereira Vinicius F Calsavara Fernand Source Type: research