The Journal of Clinical Endocrinology and Metabolism 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Lessons from prospective longitudinal follow-up of a French APECED cohort
CONCLUSION: This first prospective cohort showed a high AIRE genotype variability, with two new gene variants. The prevalence of potentially life-threatening non-endocrine manifestations, was higher with systematic screening. These manifestations could, along with age-dependent B-cell lymphopenia, contribute to disease severity. Systematic screening for all the manifestations of the syndrome would allow earlier diagnosis, supporting vaccination, and targeted therapeutic approaches.PMID:38605470 | DOI:10.1210/clinem/dgae211 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 12, 2024 Category: Endocrinology Authors: Linda Humbert Emmanuelle Proust-Lemoine Sylvain Dubucquoi Elisabeth Helen Kemp Pascale Saugier-Veber Nicole Fabien Isabelle Raymond-Top Catherine Cardot-Bauters Jean-Claude Carel Maryse Cartigny Olivier Chabre Philippe Chanson Brigitte Delemer Christine D Source Type: research
Metabolic effects of testosterone added to intensive lifestyle intervention in older men with obesity and hypogonadism
CONCLUSION: In older men with obesity and hypogonadism, adding TRT for six months to LT does not result in further improved cardiometabolic profiles, and could potentially blunt some of the metabolic benefits induced by LT.PMID:38606934 | DOI:10.1210/clinem/dgae249 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 12, 2024 Category: Endocrinology Authors: Adrian M Gonzalez-Gil Yoann Barnouin Alessandra Celli Viola Viola Marcos D Villarreal Maria Liza Duremdes Nava Adam Sciuk Clifford Qualls Reina Armamento-Villareal Dennis T Villareal Source Type: research
Evaluation of the thiazide challenge test to differentiate primary from hypercalciuria-related hyperparathyroidism
CONCLUSION: the TCT aids in discriminating patients with PHPT from those with SHPT-IH based on a rise in serum calcium. Other parameters are not different between both groups. Larger prospective trials are necessary to further define the diagnostic potential of the TCT, its most appropriate biochemical outcome variables, and decision cut-offs.PMID:38605120 | DOI:10.1210/clinem/dgae239 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 11, 2024 Category: Endocrinology Authors: Ewout Verly Bruno Lapauw Dr Charlotte Verroken Source Type: research
Outcomes of SDHB pathogenic variant carriers: A systematic review and meta-analysis
CONCLUSION: Penetrance for PPGL in SDHB PV carriers increases linearly with age. Affected carriers are at risk of developing and dying from metastatic disease, or of developing second tumors. Lifelong surveillance is appropriate.PMID:38605204 | DOI:10.1210/clinem/dgae233 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 11, 2024 Category: Endocrinology Authors: Dahlia F Davidoff Richard De Abreu Lourenco Venessa H M Tsang Diana E Benn Roderick J Clifton-Bligh Source Type: research
Mild hyponatremia is not associated with degradation of trabecular bone microarchitecture despite bone mass loss
CONCLUSIONS: Hyponatremia, at least in mild forms, is not associated with a degradation of trabecular microarchitecture, assessed non-invasively by TBS. An independent association between hyponatremia and loss of bone mass is confirmed, particularly at the total hip.PMID:38605279 | DOI:10.1210/clinem/dgae234 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 11, 2024 Category: Endocrinology Authors: Fabio Bioletto Michela Sibilla Alessandro Maria Berton Nunzia Prencipe Emanuele Varaldo Federica Maiorino Daniela Cuboni Alessia Pusterla Valentina Gasco Silvia Grottoli Ezio Ghigo Emanuela Arvat Massimo Procopio Marco Barale Source Type: research
Opposing effects of cannabidiol in patient-derived neuroendocrine tumor, pheochromocytoma/paraganglioma primary cultures
CONCLUSIONS: We suggest a potential novel treatment option for some NETs/PPGLs, but also provide evidence for caution when applying cannabinoids as supportive therapy for pain or appetite management to cancer patients, and possibly as health supplements.PMID:38605427 | DOI:10.1210/clinem/dgae241 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 11, 2024 Category: Endocrinology Authors: Katharina Wang Laura Schober Alessa Fischer Nicole Bechmann Julian Maurer Lea Peischer Astrid Reul Constanze Hantel Martin Reincke Felix Beuschlein Mercedes Robledo Hermine Mohr Natalia S Pellegata Katharina Schilbach Thomas Kn ösel Matthias Ilmer Martin Source Type: research
The Impact of High Adiposity on Endometrial Progesterone Response and Metallothionein Regulation
CONCLUSIONS: Taken together, the in vitro and in vivo systems used here revealed that high adiposity or obesity can alter MT expression by decreasing progesterone response in the epithelial cells and increasing oxidative stress in the stroma.PMID:38597153 | DOI:10.1210/clinem/dgae236 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 10, 2024 Category: Endocrinology Authors: Alina R Murphy Huma Asif Harun Cingoz Fran çoise A Gourronc James A Ankrum Aloysius J Klingelhutz J Julie Kim Source Type: research
A Clinical Trial of High Dose Growth Hormone in a Patient with a Dominant Negative Growth Hormone Receptor Mutation
CONCLUSIONS: A precision medicine approach of extremely high dose GH was able to overcome GH resistance in a patient with a dominant-negative variant in the GH receptor resulting in elevated GH binding protein levels.PMID:38597155 | DOI:10.1210/clinem/dgae244 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 10, 2024 Category: Endocrinology Authors: Nadia Merchant Lisa Houchin Kimberly Boucher Andrew Dauber Source Type: research
Cystatin C is a predictor for long-term All-Cause and Cardiovascular Mortality in US Adults with Metabolic Syndrome
CONCLUSION: MetS patients with elevated CysC levels have a higher risk of all-cause, CVD, and cancer death. CysC may predict MetS all-cause and CVD mortality.PMID:38597157 | DOI:10.1210/clinem/dgae225 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 10, 2024 Category: Endocrinology Authors: Xiaoying Song Lijiao Xiong Tianting Guo Xue Chen Pinjun Zhang Xiaoan Zhang Zhen Liang Source Type: research
Comparing ChatGPT's and surgeon's responses to thyroid-related questions from patients
CONCLUSIONS: ChatGPT performed better than junior specialist and senior specialist in answering common thyroid-related questions, but further research is needed to validate the logical ability of the ChatGPT for complex thyroid questions.PMID:38597169 | DOI:10.1210/clinem/dgae235 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 10, 2024 Category: Endocrinology Authors: Siyin Guo Ruicen Li Genpeng Li Wenjie Chen Jing Huang Linye He Yu Ma Liying Wang Hongping Zheng Chunxiang Tian Yatong Zhao Xinmin Pan Hongxing Wan Dasheng sLiu Zhihui Li Jianyong Lei Source Type: research
The Impact of High Adiposity on Endometrial Progesterone Response and Metallothionein Regulation
CONCLUSIONS: Taken together, the in vitro and in vivo systems used here revealed that high adiposity or obesity can alter MT expression by decreasing progesterone response in the epithelial cells and increasing oxidative stress in the stroma.PMID:38597153 | DOI:10.1210/clinem/dgae236 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 10, 2024 Category: Endocrinology Authors: Alina R Murphy Huma Asif Harun Cingoz Fran çoise A Gourronc James A Ankrum Aloysius J Klingelhutz J Julie Kim Source Type: research
A Clinical Trial of High Dose Growth Hormone in a Patient with a Dominant Negative Growth Hormone Receptor Mutation
CONCLUSIONS: A precision medicine approach of extremely high dose GH was able to overcome GH resistance in a patient with a dominant-negative variant in the GH receptor resulting in elevated GH binding protein levels.PMID:38597155 | DOI:10.1210/clinem/dgae244 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 10, 2024 Category: Endocrinology Authors: Nadia Merchant Lisa Houchin Kimberly Boucher Andrew Dauber Source Type: research
Cystatin C is a predictor for long-term All-Cause and Cardiovascular Mortality in US Adults with Metabolic Syndrome
CONCLUSION: MetS patients with elevated CysC levels have a higher risk of all-cause, CVD, and cancer death. CysC may predict MetS all-cause and CVD mortality.PMID:38597157 | DOI:10.1210/clinem/dgae225 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 10, 2024 Category: Endocrinology Authors: Xiaoying Song Lijiao Xiong Tianting Guo Xue Chen Pinjun Zhang Xiaoan Zhang Zhen Liang Source Type: research
Comparing ChatGPT's and surgeon's responses to thyroid-related questions from patients
CONCLUSIONS: ChatGPT performed better than junior specialist and senior specialist in answering common thyroid-related questions, but further research is needed to validate the logical ability of the ChatGPT for complex thyroid questions.PMID:38597169 | DOI:10.1210/clinem/dgae235 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 10, 2024 Category: Endocrinology Authors: Siyin Guo Ruicen Li Genpeng Li Wenjie Chen Jing Huang Linye He Yu Ma Liying Wang Hongping Zheng Chunxiang Tian Yatong Zhao Xinmin Pan Hongxing Wan Dasheng sLiu Zhihui Li Jianyong Lei Source Type: research
Response to Letter to the Editor from Janot et al: « Single-Exon Deletions of ZNRF3 Exon 2 cause Congenital Adrenal Hypoplasia »
J Clin Endocrinol Metab. 2024 Apr 9:dgae230. doi: 10.1210/clinem/dgae230. Online ahead of print.NO ABSTRACTPMID:38591244 | DOI:10.1210/clinem/dgae230 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 9, 2024 Category: Endocrinology Authors: Naoko Amano Satoshi Narumi Tomohiro Ishii Tomonobu Hasegawa Source Type: research
