Regulated differentiation of stem cells into an artificial 3D liver as a transplantable source.
Authors: Chen F, Wang H, Xiao J Abstract End-stage liver disease is one of the leading causes of death around the world. Since insufficient sources of transplantable liver and possible immune rejection severely hinder the wide application of conventional liver transplantation therapy, artificial three-dimensional (3D) liver culture and assembly from stem cells have become a new hope for patients with end-stage liver diseases, such as cirrhosis and liver cancer. However, the induced differentiation of single-layer or 3D-structured hepatocytes from stem cells cannot physiologically support essential liver functions d...
Source: Clinical and molecular hepatology - February 28, 2020 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Switching to systemic therapy after locoregional treatment failure: Definition and best timing.
Authors: Ogasawara S, Ooka Y, Koroki K, Maruta S, Kanzaki H, Kanayama K, Kobayashi K, Kiyono S, Nakamura M, Kanogawa N, Saito T, Kondo T, Suzuki E, Nakamoto S, Tawada A, Chiba T, Arai M, Kato J, Kato N Abstract In patients with unresectable hepatocellular carcinoma (HCC) without both macrovascular invasion and extrahepatic metastasis, the initial treatment choice recommended is transarterial chemoembolization (TACE). Before sorafenib came into wide use, TACE had been pointlessly carried out repeatedly. It was in the early 2010s that the concept of TACE refractory was advocated. Two retrospective studies from Japan ...
Source: Clinical and molecular hepatology - January 17, 2020 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

KASL clinical practice guidelines for liver cirrhosis: Varices, hepatic encephalopathy, and related complications.
Authors: Korean Association for the Study of the Liver (KASL) PMID: 31918536 [PubMed - as supplied by publisher] (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - January 11, 2020 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Comparisons between non-alcoholic steatohepatitis and alcohol-related hepatocellular carcinoma.
Authors: Kumar R, Goh BG, Kam JW, Chang PE, Tan CK Abstract Background and Aim: Non-alcoholic liver disease and alcoholic liver disease begin as simple steatosis that may progress to steatohepatitis and ensuing liver-related complications such as cirrhosis and hepatocellular carcinoma (HCC). We explored differences in characteristics between non-alcoholic steatohepatitis (NASH) and alcoholic steatohepatitis-related (ASH) HCC. Methods: NASH and ASH patients were identified from our department's prospective HCC database. A total of 54 and 45 patients met predefined inclusion and exclusion criteria for the NASH-HC...
Source: Clinical and molecular hepatology - January 10, 2020 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

A leap for the journal: Clinical and Molecular Hepatology enters a new era.
Authors: Kim YJ PMID: 31838835 [PubMed - as supplied by publisher] (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - December 18, 2019 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Drug induced liver injury: East versus West - a systematic review and meta-analysis.
Authors: Low EXS, Zheng Q, Chan E, Lim SG Abstract Drug induced liver injury (DILI) may be different in the East compared to the West due to differing disease prevalence, prescribing patterns and pharmacogenetic profiles. To review existing literature on causative agents of DILI in the East compared to the West, a comprehensive literature search was performed on electronic databases: MEDLINE/PubMed, Embase, Cochrane Library and China National Knowledge Infrastructure without language restrictions. Studies which involve patients having DILI and reported the frequency of causative agents were included. A random effec...
Source: Clinical and molecular hepatology - December 11, 2019 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Limited expression of TLR9 on T cells and its functional consequences in patients with nonalcoholic fatty liver disease.
Conclusions: The positive associations between TLR9 and anthropometric, clinical, and histological features and the crucial role of IFN-γ-in NAFLD suggest that limited TLR9 expression and production of IFN-γ play a protective role in patients with simple steatosis. PMID: 31795627 [PubMed - as supplied by publisher] (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - December 7, 2019 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Clinical characteristics of portal hypertension complicated by gastroesophageal varices in patients with my- eloproliferative neoplasms.
Authors: Lee J, Sung PS, Eom KS, Yang H, Lee SK, Bwa AH, Lozada A, Jang JW, Bae SH, Choi JY, Yoon SK PMID: 31760741 [PubMed - as supplied by publisher] (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - November 27, 2019 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Multimodal sequential treatment for occluded TIPS: case report and review of literature.
Authors: De Matthaeis N, Di Stasi C, Pizzolante F, Manfredi R, Rapaccini GL, Miele L PMID: 31735021 [PubMed - as supplied by publisher] (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - November 20, 2019 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Sensitivity of ultrasound in detecting hepatocellular carcinoma in obese patients compared to explant pathology as the gold standard.
We examined US sensitivity for diagnosis of HCC in obese patients. Methods: Liver transplant patients data with HCC in explant was used (January 2012-December 2017). All patients underwent liver US within 3 months of diagnosis of HCC. Number/size of HCC lesions were extracted from radiologic and pathologic reports. Obesity was defined as BMI ≥30 kg/m2. Results: One hundred sixteen patients were included. 80% were male, with mean BMI of 31 kg/m2. The most common underlying liver disease was hepatitis C virus (62%). At the time of diagnosis, median number of HCC lesions was 2 (interquartile range [IQR], 1-3), and ...
Source: Clinical and molecular hepatology - November 17, 2019 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Application of transient elastography in nonalcoholic fatty liver disease.
This article reviews the performance and limitations of transient elastography in NAFLD and highlights its clinical applications. We also discuss the reliability criteria for transient elastography examination and factors associated with false-positive liver stiffness measurements. PMID: 31696690 [PubMed - as supplied by publisher] (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - November 8, 2019 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Fibrolamellar hepatocellular carcinoma-related hyperammonemic encephalopathy: up to now and next steps.
Authors: Surjan RCT, Santos ESD, Silveira SDP, Makdissi FF, Machado MAC PMID: 31679315 [PubMed - as supplied by publisher] (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - November 5, 2019 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Trends in the prevalence of chronic liver disease in the Korean adult population, 1998-2017.
This study aimed to evaluate whether the CLD prevalence changed between 1998-2001 and 2016-2017. Data were extracted from the Korea National Health and Nutrition Examination Survey (1998-2001 to 2016-2017; n=25,893). Non-alcoholic fatty liver disease (NAFLD) was defined as a hepatic steatosis index>36 in the absence of any other evidence of CLD. The definition of alcoholrelated liver disease (ALD) was excessive alcohol consumption (≥210 g/week for men and ≥140 g/week for women) and an ALD/NAFLD index>0. The prevalence of NAFLD increased from 18.6% (95% confidence interval [CI], 17.8-19.5%) in 1998-2001 to 21.5%...
Source: Clinical and molecular hepatology - November 5, 2019 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Influence of some methylated hepatocarcinogenesis-related genes on the response to antiviral therapy and development of fibrosis in chronic hepatitis C patients.
Authors: Mostafa WSEM, Al-Dahr MHS, Omran DAH, Abdullah ZF, Elmasry SAH, Ibrahim MN Abstract Epigenetics involved in multiple normal cellular processes. Previous research have revealed the role of hepatitis C virus infection in accelerating methylation process and affecting response to treatment in chronic hepatitis patients. This work aimed to elucidate the role of promoter methylation (PM) in response to antiviral therapy, and its contribution to the development of fibrosis through hepatocarcinogenesis-related genes. A total of 159 chronic hepatitis Egyptian patients versus 100 healthy control group were included...
Source: Clinical and molecular hepatology - October 22, 2019 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Extrahepatic manifestations of hepatitis E virus: An overview.
Authors: Fousekis FS, Mitselos IV, Christodoulou DK Abstract Hepatitis E virus (HEV) is a significant health problem with approximately 20 million individuals infected annually. HEV infection has been associated with a wide spectrum of extrahepatic manifestations, including neurological, hematological and renal disorders. Guillain-Barré syndrome and neuralgic amyotrophy are the most frequent neurological manifestations. In addition, HEV infection has been observed with other neurological diseases, such as encephalitis, myelitis and Bell's palsy. Hematologic manifestations include anemia due to glucose-6-phos...
Source: Clinical and molecular hepatology - October 12, 2019 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Vimentin as a potential therapeutic target in sorafenib resistant HepG2, a HCC model cell line.
Conclusions: Hence, our study for the first time highlighted the probable therapeutic potential of vimentin in sorafenib resistant HepG2, a HCC model cell line. PMID: 31564085 [PubMed - as supplied by publisher] (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - October 2, 2019 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Hyperammonemic encephalopathy: An unusual presentation of fibrolamellar hepatocellular carcinoma.
Authors: Thakral N, Simonetto DA PMID: 31422648 [PubMed - as supplied by publisher] (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - August 21, 2019 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Bi-monthly hepatic arterial infusion chemotherapy as a novel strategy for advanced hepatocellular carcinoma in decompensated cirrhotic patients.
Conclusions: Given the preservation of hepatic functional reserve afforded by B-HAIC chemotherapy in patients with decompensated cirrhosis, B-HAIC might be an acceptable alternative strategy for aHCC patients who do not respond to TACE. PMID: 31405269 [PubMed - as supplied by publisher] (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - August 15, 2019 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Incidence and risk factors of dysphagia after variceal band ligation.
Conclusions: Approximately 30% of patients developed new-onset, chronic dysphagia post-EVL. Incident dysphagia was associated with a non-emergent initial banding session. The mechanism for dysphagia remains unknown. PMID: 31315388 [PubMed - as supplied by publisher] (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - July 20, 2019 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Hepatitis B screening rates and reactivation in solid organ malignancy patients undergoing chemotherapy in Southern Thailand.
Conclusions: The prevalence of HBV in SOM patients undergoing CMT in our study was similar to the estimated prevalence in general Thai population, but the screening rate was quite low. Cases of HBVr causing significant hepatitis occurred in the unscreened group; therefore, HBV screening and treatment in SOM patients should be considered in HBV-endemic areas. PMID: 31309773 [PubMed - as supplied by publisher] (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - July 17, 2019 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Serum Wisteria floribunda agglutinin-positive human Mac-2 binding protein level predicts recurrence of hepatitis B virus-related hepatocellular carcinoma after curative resection.
Authors: Kim HS, Kim SU, Kim BK, Park JY, Kim DY, Ahn SH, Han KH, Park YN, Han DH, Kim KS, Choi JS, Choi GH, Kim HS Abstract Background/Aims: To investigate whether serum Wisteria floribunda agglutinin-positive human Mac-2-binding protein (WFA+-M2BP) can predict the recurrence of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) after curative resection. Methods: Patients with chronic hepatitis B (CHB) who underwent curative resection for HCC between 2004 and 2015 were eligible for the study. Recurrence was sub-classified as early (
Source: Clinical and molecular hepatology - June 29, 2019 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Carnitine palmitoyl transferase 1A deficiency in an adult with recurrent severe steato hepatitis aggravated by high pathologic or physiologic demands: A roller-coaster for internists.
Authors: Phowthongkum P, Suphapeetiporn K, Shotelersuk V PMID: 31234250 [PubMed - as supplied by publisher] (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - June 26, 2019 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Transjugular intrahepatic portosystemic shunt assisted with trans-splenic access.
Authors: Cheng Z, Wang F, Liu J PMID: 31212396 [PubMed - as supplied by publisher] (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - June 20, 2019 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

The fibrogenic process and the unleashing of acute-on-chronic liver failure.
Authors: López-Sánchez GN, Dóminguez-Pérez M, Uribe M, Nuño-Lámbarri N Abstract Acute-on-chronic liver failure (ACLF) is a life-threatening condition characterized by a rapid deterioration of previously well-compensated chronic liver diseases. One of the main obstacles in ACLF is the lack of knowledge of the pathogenesis and specific broad-spectrum treatments. An excessive systemic inflammatory response has been proposed to explain the pathogenesis of ACLF; this hypothesis involves stellate cells, which are implicated in many liver homeostatic functions that include vitamin...
Source: Clinical and molecular hepatology - June 16, 2019 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

The management of polycystic liver disease by tolvaptan.
Authors: Takenaka T, Miura S, Kitajima M PMID: 31189297 [PubMed - as supplied by publisher] (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - June 14, 2019 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

KASL clinical practice guidelines for management of chronic hepatitis B.
Authors: Korean Association for the Study of the Liver (KASL) PMID: 31185710 [PubMed - as supplied by publisher] (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - June 13, 2019 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Are there differences in risk factors, microbial aspects, and prognosis of cellulitis between compensated and decompensated hepatitis C virus-related cirrhosis?
Conclusions: Cellulitis in compensated cirrhosis is different from that of decompensated patients regarding microorganisms, pathogenesis, and prognosis. Cellulitis has a poor prognosis, with mortality rates approaching 100% in decompensated patients with gram-negative cellulitis. Stratifying patients according to severity of cirrhosis is important to identify the proper empirical antibiotic and to decide the proper means of care. PMID: 31177653 [PubMed - as supplied by publisher] (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - June 12, 2019 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Serum leptin in non-alcoholic fatty liver disease: Ambiguous clinical implications concerning cardiovascular disease.
Authors: Patoulias D, Imprialos K, Stavropoulos K, Doumas M PMID: 31142103 [PubMed - as supplied by publisher] (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - June 2, 2019 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Effects of different exercise modalities on novel hepatic steatosis indices in overweight women with type 2 diabetes.
Authors: Banitalebi E, Faramarzi M, Nasiri S, Mardaniyan M, Rabiee V Abstract Background/Aims: Fatty liver is a clinical and pathologic condition in individuals with type 2 diabetes (T2D). The purpose of this study is to examine the effects of different exercise modalities on non-alcoholic fatty liver indices (fatty liver index [FLI], lipid accumulation product [LAP], hepatic steatosis index [HSI], and Framingham Steatosis Index [FSI]) in women with T2D. Methods: Fifty-two women with T2D and a mean age of 55.07±5.92 yrs, body mass index (BMI) 28.94±4.09 kg/m2 , and hemoglobin A1c (HbA1c) 9.41&plus...
Source: Clinical and molecular hepatology - June 2, 2019 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Risk assessment of hepatocellular carcinoma development for indeterminate hepatic nodules in patients with chronic hepatitis B.
Conclusions: HCC history, but not RadCT score, predicted CHB-related HCC development from LI-RADS 2/3 nodules. New risk models optimized for MRI-defined indeterminate nodules are required. PMID: 31146508 [PubMed - as supplied by publisher] (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - June 2, 2019 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

An integrated analysis of elbasvir/grazoprevir in Korean patients with hepatitis C virus genotype 1b infection.
Conclusions: In this retrospective analysis, EBR/GZR administered for 12 weeks was well-tolerated and highly effective in Korean patients with HCV GT1b infection. PMID: 31132846 [PubMed - as supplied by publisher] (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - May 28, 2019 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

A survey on transarterial chemoembolization refractoriness and a real-world treatment pattern for hepatocellular carcinoma in Korea.
Conclusions: Treatment of HCC is often based on the clinical judgment of clinicians because of the heterogeneity among individuals. Experts need to continue discussions on the standardization and sub-classification of HCC treatment guidelines in Korea. PMID: 31104456 [PubMed - as supplied by publisher] (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - May 21, 2019 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Persistent elevation of aminotransferases in liver transplant in association with chronic norovirus infection.
Authors: Khayat AA, Telega GW PMID: 31062535 [PubMed - as supplied by publisher] (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - May 8, 2019 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Upcoming direct acting antivirals for hepatitis C patients with a prior treatment failure.
Authors: Parigi TL, Torres MCP, Aghemo A Abstract Despite the high efficacy of direct acting antivirals (DAAs) not all patients successfully clear hepatitis C virus infection, in fact, approximately 1-3% fail to reach a sustained virological response 12 weeks after end of treatment. DAA failures are characterized by advanced liver disease, specific genotypes/subtypes and resistance associated substitutions to the DAA class they have been treated with. Current European Association for the Study of the Liver guidelines recommend three therapeutic options for such patients. The first is a 12 week course of sofosbuvir ...
Source: Clinical and molecular hepatology - May 4, 2019 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Ultraselective conventional transarterial chemoembolization: When and how?
Authors: Miyayama S Abstract Ultraselective conventional transarterial chemoembolization (cTACE), defined as cTACE at the most distal portion of the subsubsegmental hepatic artery, is mainly performed for hepatocellular carcinoma (HCC) ≤5 cm. Distal advancement of a microcatheter enables injection of a larger volume of iodized oil into the portal vein in the limited area under non-physiological hemodynamics. As a result, the reversed portal flow into the tumor through the drainage route of the tumor that occurs when the hepatic artery is embolized is temporarily blocked. By adding gelatin sponge slurry embolizat...
Source: Clinical and molecular hepatology - April 27, 2019 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Appropriate treatment modality for solitary small hepatocellular carcinoma: Radiofrequency ablation vs. Resection vs. Transplantation?
Authors: Ahn KS, Kang KJ Abstract There has been controversy regarding the first-line treatment modality for the patients who have small solitary hepatocellular carcinoma (HCC); radiofrequency ablation (RFA) or percutaneous ethanol injection (PEI), surgical hepatic resection (HR) and liver transplantation (LT). For selection of treatment modality of HCC, it should be considered of hepatic reservoir function as well as the tumor stage. If the liver function is good enough, HR may be the first choice regardless of the tumor size. However, recent studies comparing RFA with resection showed comparable outcome and simil...
Source: Clinical and molecular hepatology - April 24, 2019 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Sarcopenia: Ammonia metabolism and hepatic encephalopathy.
Authors: Jindal A, Jagdish RK Abstract Sarcopenia (loss of muscle mass and/or strength) frequently complicates liver cirrhosis and adversely affects the quality of life; cirrhosis related liver decompensation and significantly decreases wait-list and post-liver transplantation survival. The main therapeutic strategies to improve or reverse sarcopenia include dietary interventions (supplemental calorie and protein intake), increased physical activity (supervised resistance and endurance exercises), hormonal therapy (testosterone), and ammonia lowering agents (L-ornithine L-aspartate, branch chain amino acids) as wel...
Source: Clinical and molecular hepatology - April 24, 2019 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Underlying liver disease and advanced stage liver cancer are associated with elevated neutrophil-lymphocyte ratio.
This study evaluates NLR in a large cohort of HCC patients. Methods: We retrospectively reviewed 789 HCC cases (1993-2017) for demographics, tumor characteristics, treatment, and survival. NLR was stratified into NLR ≥1.5 and NLR ≥3 and analyzed for correlation with American Joint Committee on Cancer (AJCC) and Barcelona Clinic Liver Cancer (BCLC) stages. In 235 patients who underwent liver resection, survival and recurrence were evaluated by NLR. Results: In 789 HCC cases, mean NLR was increased with advanced AJCC and BCLC stages. Hepatitis C patients were less likely to have NLR ≥1.5 and ≥3. Non-alcoh...
Source: Clinical and molecular hepatology - April 21, 2019 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Detect or not to detect very early stage hepatocellular carcinoma? The western perspective.
In conclusion, attempting to detect very early stage HCC is difficult to achieve and controversial. Clinicians should take into account of the risk and the benefit of diagnostic tests, LT candidacy of patients and the local organ allocation system. PMID: 30924328 [PubMed - as supplied by publisher] (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - March 31, 2019 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Immunologic strategies and outcomes in ABO-incompatible living donor liver transplantation.
Authors: Oh J, Kim JM Abstract Antibody mediated rejection (AMR) after adult ABO-incompatible living donor liver transplantation (ABO-I LDLT) induced hepatic necrosis or diffuse intrahepatic biliary complications, which were related with poor graft and patient survival. Various desensitization protocols have been used to overcome these problems. Since using rituximab, the outcomes of ABO-I LDLT show a similar survival rate to those of ABO-compatible living donor liver transplantation. However, diffuse bile duct complications still occur after ABO-I LDLT. We have reviewed the past and current immune strategies for d...
Source: Clinical and molecular hepatology - March 28, 2019 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Portal pressure gradient and serum albumin: A simple combined parameter associated with the appearance of ascites in decompensated cirrhosis treated with transjugular intrahepatic portosystemic shunt.
Conclusions: The combined measurement of pre-PPG and albumin, defined as PPA, may provide a better way to predict post-TIPS ascites in decompensated cirrhosis, which underlines the need for a large clinical trial in the future. PMID: 30897897 [PubMed - as supplied by publisher] (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - March 24, 2019 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Evaluation of bioenergetic and mitochondrial function in liver transplantation.
Authors: Martins RM, Teodoro JS, Furtado E, Rolo AP, Palmeira CM, Tralhão JG Abstract Background/Aims: We measured changes in mitochondrial function and bioenergetics that occur during ischemia/ reperfusion in fresh liver samples of patients undergoing liver transplantation. These variations correlated with markers of liver function and clinical outcome. Ischemia/reperfusion injury related to liver transplantation affects mitochondrial function and bioenergetics. Experimental studies were conducted to identify the role of bioenergetics and mitochondrial dysfunction. To the best of our knowledge, no investiga...
Source: Clinical and molecular hepatology - March 24, 2019 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Effects of zolpidem on sleep parameters in patients with cirrhosis and sleep disturbances: A randomized, placebo-controlled trial.
Conclusions: Four weeks of 5 mg daily zolpidem in CTP class A or B cirrhosis patients with insomnia led to significant increases in TST and sleep efficiency and improvement in polysomnographic parameters of sleep initiation and maintenance without any significant change in sleep architecture. PMID: 30856689 [PubMed - as supplied by publisher] (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - March 12, 2019 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Hepatocellular carcinoma surveillance in the 21st century: Saving lives or causing harm?
Authors: Hanouneh IA, Alkhouri N, Singal AG Abstract Hepatocellular carcinoma (HCC) is the third most common cause of cancer related death worldwide. Prognosis and treatment options largely depend on tumor stage at diagnosis, with curative treatments only available if detected at an early stage. However, two thirds of patients with HCC are diagnosed at a late stage and not eligible for cure. Therefore several liver professional societies recommend HCC surveillance using abdominal ultrasound with or without alpha fetoprotein in at-risk populations, including patients with cirrhosis and subsets of those with chronic ...
Source: Clinical and molecular hepatology - March 5, 2019 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Safety margin of embolized area can reduce local recurrence of hepatocellular carcinoma after superselective transarterial chemoembolization.
Authors: Bannangkoon K, Hongsakul K, Tubtawee T, Piratvisuth T Abstract Background/Aims: We aimed to determine the relationship between the safety margin of an embolized area and local tumor recurrence (LTR) of patients with hepatocellular carcinoma (HCC) who underwent superselective transarterial chemoembolization (TACE). Methods: The medical records of 77 HCC patients with 109 HCC nodules who underwent superselective TACE were retrospectively analyzed for LTR. Univariate and multivariate analyses were performed for 16 potential factors using Cox proportional hazard regression. Iodized oil deposition on cone-b...
Source: Clinical and molecular hepatology - March 1, 2019 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Efficacy of L-carnitine on ribavirin-induced hemolytic anemia in patients with hepatitis C virus infection.
Conclusions: L-carnitine supplementation alleviates ribavirin-induced hemolytic anemia in patients with HCV and helps relieve the physical burden of treatment with ribavirin-containing regimens. These advantages significantly increase the likelihood of achieving SVR. PMID: 30798587 [PubMed - as supplied by publisher] (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - February 26, 2019 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Advances in ultrasound diagnosis in chronic liver diseases.
This article reviews the wide ranges of application in the abdominal US and describes the recent progress in the diagnosis of chronic liver diseases. PMID: 30773001 [PubMed - as supplied by publisher] (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - February 19, 2019 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Unmet need in chronic hepatitis B management.
Authors: Liang LY, Wong GL Abstract Despite all these exciting developments, there remain some unmet needs in the management for patients with chronic hepatitis B (CHB). As majority of CHB patients are going to use oral nucleos(t)ide analogues (NAs) for decades, Safety profile of NAs is of no doubt an important issue. The newest nucleotide analogue tenofovir alafenamide is potent in terms of viral suppression, together with favourable renal and bone safety profile. Biochemical response as reflected by alanine aminotransferase (ALT) normalization is recently found to be prognostically important. Patients who achieve...
Source: Clinical and molecular hepatology - February 15, 2019 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Comparison of international guidelines for noninvasive diagnosis of hepatocellular carcinoma: 2018 update.
Authors: Kim TH, Kim SY, Tang A, Lee JM Abstract The goal of this review is to present the similarities and differences among the latest guidelines for noninvasive diagnosis of hepatocellular carcinoma (HCC) of American Association for the Study of Liver Disease (AASLD), European Association for the Study of the Liver (EASL), Liver Imaging Reporting and Data System (LI-RADS), Asian Pacific Association for the Study of the Liver (APASL), and Korean Liver Cancer Association- National Cancer Center (KLCA-NCC) of Korea. In 2018, major guideline updates have been proposed by the AASLD, EASL and KLCA-NCC; AASLD newly inc...
Source: Clinical and molecular hepatology - February 15, 2019 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Direct-acting antivirals response in hepatocellular carcinoma: Does the presence of hepatocellular carcinoma matter?
Authors: Huang CF, Yu ML Abstract During the clinical trial development of directly acting antivirals (DAAs), evidence regarding the treatment efficacy in chronic hepatitis C patients with hepatocellular carcinoma (HCC) was scarce because these patients have always been excluded. Apart from the clinical trials, more HCC patients are currently being treated in daily practice, given that these treatments are highly effective and involve well-tolerated regimens. Large scale, real-world studies have demonstrated potentially suboptimal antiviral treatment efficacy in HCC patients who received DAAs. It is postulated that...
Source: Clinical and molecular hepatology - February 12, 2019 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research