Underlying liver disease and advanced stage liver cancer are associated with elevated neutrophil-lymphocyte ratio.
This study evaluates NLR in a large cohort of HCC patients. Methods: We retrospectively reviewed 789 HCC cases (1993-2017) for demographics, tumor characteristics, treatment, and survival. NLR was stratified into NLR ≥1.5 and NLR ≥3 and analyzed for correlation with American Joint Committee on Cancer (AJCC) and Barcelona Clinic Liver Cancer (BCLC) stages. In 235 patients who underwent liver resection, survival and recurrence were evaluated by NLR. Results: In 789 HCC cases, mean NLR was increased with advanced AJCC and BCLC stages. Hepatitis C patients were less likely to have NLR ≥1.5 and ≥3. Non-alcoh...
Source: Clinical and molecular hepatology - April 21, 2019 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Detect or not to detect very early stage hepatocellular carcinoma? The western perspective.
In conclusion, attempting to detect very early stage HCC is difficult to achieve and controversial. Clinicians should take into account of the risk and the benefit of diagnostic tests, LT candidacy of patients and the local organ allocation system. PMID: 30924328 [PubMed - as supplied by publisher] (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - March 31, 2019 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Immunologic strategies and outcomes in ABO-incompatible living donor liver transplantation.
Authors: Oh J, Kim JM Abstract Antibody mediated rejection (AMR) after adult ABO-incompatible living donor liver transplantation (ABO-I LDLT) induced hepatic necrosis or diffuse intrahepatic biliary complications, which were related with poor graft and patient survival. Various desensitization protocols have been used to overcome these problems. Since using rituximab, the outcomes of ABO-I LDLT show a similar survival rate to those of ABO-compatible living donor liver transplantation. However, diffuse bile duct complications still occur after ABO-I LDLT. We have reviewed the past and current immune strategies for d...
Source: Clinical and molecular hepatology - March 28, 2019 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Portal pressure gradient and serum albumin: A simple combined parameter associated with the appearance of ascites in decompensated cirrhosis treated with transjugular intrahepatic portosystemic shunt.
Conclusions: The combined measurement of pre-PPG and albumin, defined as PPA, may provide a better way to predict post-TIPS ascites in decompensated cirrhosis, which underlines the need for a large clinical trial in the future. PMID: 30897897 [PubMed - as supplied by publisher] (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - March 24, 2019 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Evaluation of bioenergetic and mitochondrial function in liver transplantation.
Authors: Martins RM, Teodoro JS, Furtado E, Rolo AP, Palmeira CM, Tralhão JG Abstract Background/Aims: We measured changes in mitochondrial function and bioenergetics that occur during ischemia/ reperfusion in fresh liver samples of patients undergoing liver transplantation. These variations correlated with markers of liver function and clinical outcome. Ischemia/reperfusion injury related to liver transplantation affects mitochondrial function and bioenergetics. Experimental studies were conducted to identify the role of bioenergetics and mitochondrial dysfunction. To the best of our knowledge, no investiga...
Source: Clinical and molecular hepatology - March 24, 2019 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Effects of zolpidem on sleep parameters in patients with cirrhosis and sleep disturbances: A randomized, placebo-controlled trial.
Conclusions: Four weeks of 5 mg daily zolpidem in CTP class A or B cirrhosis patients with insomnia led to significant increases in TST and sleep efficiency and improvement in polysomnographic parameters of sleep initiation and maintenance without any significant change in sleep architecture. PMID: 30856689 [PubMed - as supplied by publisher] (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - March 12, 2019 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Hepatocellular carcinoma surveillance in the 21st century: Saving lives or causing harm?
Authors: Hanouneh IA, Alkhouri N, Singal AG Abstract Hepatocellular carcinoma (HCC) is the third most common cause of cancer related death worldwide. Prognosis and treatment options largely depend on tumor stage at diagnosis, with curative treatments only available if detected at an early stage. However, two thirds of patients with HCC are diagnosed at a late stage and not eligible for cure. Therefore several liver professional societies recommend HCC surveillance using abdominal ultrasound with or without alpha fetoprotein in at-risk populations, including patients with cirrhosis and subsets of those with chronic ...
Source: Clinical and molecular hepatology - March 5, 2019 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Safety margin of embolized area can reduce local recurrence of hepatocellular carcinoma after superselective transarterial chemoembolization.
Authors: Bannangkoon K, Hongsakul K, Tubtawee T, Piratvisuth T Abstract Background/Aims: We aimed to determine the relationship between the safety margin of an embolized area and local tumor recurrence (LTR) of patients with hepatocellular carcinoma (HCC) who underwent superselective transarterial chemoembolization (TACE). Methods: The medical records of 77 HCC patients with 109 HCC nodules who underwent superselective TACE were retrospectively analyzed for LTR. Univariate and multivariate analyses were performed for 16 potential factors using Cox proportional hazard regression. Iodized oil deposition on cone-b...
Source: Clinical and molecular hepatology - March 1, 2019 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Efficacy of L-carnitine on ribavirin-induced hemolytic anemia in patients with hepatitis C virus infection.
Conclusions: L-carnitine supplementation alleviates ribavirin-induced hemolytic anemia in patients with HCV and helps relieve the physical burden of treatment with ribavirin-containing regimens. These advantages significantly increase the likelihood of achieving SVR. PMID: 30798587 [PubMed - as supplied by publisher] (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - February 26, 2019 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Advances in ultrasound diagnosis in chronic liver diseases.
This article reviews the wide ranges of application in the abdominal US and describes the recent progress in the diagnosis of chronic liver diseases. PMID: 30773001 [PubMed - as supplied by publisher] (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - February 19, 2019 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Unmet need in chronic hepatitis B management.
Authors: Liang LY, Wong GL Abstract Despite all these exciting developments, there remain some unmet needs in the management for patients with chronic hepatitis B (CHB). As majority of CHB patients are going to use oral nucleos(t)ide analogues (NAs) for decades, Safety profile of NAs is of no doubt an important issue. The newest nucleotide analogue tenofovir alafenamide is potent in terms of viral suppression, together with favourable renal and bone safety profile. Biochemical response as reflected by alanine aminotransferase (ALT) normalization is recently found to be prognostically important. Patients who achieve...
Source: Clinical and molecular hepatology - February 15, 2019 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Comparison of international guidelines for noninvasive diagnosis of hepatocellular carcinoma: 2018 update.
Authors: Kim TH, Kim SY, Tang A, Lee JM Abstract The goal of this review is to present the similarities and differences among the latest guidelines for noninvasive diagnosis of hepatocellular carcinoma (HCC) of American Association for the Study of Liver Disease (AASLD), European Association for the Study of the Liver (EASL), Liver Imaging Reporting and Data System (LI-RADS), Asian Pacific Association for the Study of the Liver (APASL), and Korean Liver Cancer Association- National Cancer Center (KLCA-NCC) of Korea. In 2018, major guideline updates have been proposed by the AASLD, EASL and KLCA-NCC; AASLD newly inc...
Source: Clinical and molecular hepatology - February 15, 2019 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Direct-acting antivirals response in hepatocellular carcinoma: Does the presence of hepatocellular carcinoma matter?
Authors: Huang CF, Yu ML Abstract During the clinical trial development of directly acting antivirals (DAAs), evidence regarding the treatment efficacy in chronic hepatitis C patients with hepatocellular carcinoma (HCC) was scarce because these patients have always been excluded. Apart from the clinical trials, more HCC patients are currently being treated in daily practice, given that these treatments are highly effective and involve well-tolerated regimens. Large scale, real-world studies have demonstrated potentially suboptimal antiviral treatment efficacy in HCC patients who received DAAs. It is postulated that...
Source: Clinical and molecular hepatology - February 12, 2019 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Discussion on critical points for a tailored therapy to cure hepatitis C virus infection.
Authors: Marascio N, Quirino A, Barreca GS, Galati L, Costa C, Pisani V, Mazzitelli M, Matera G, Liberto MC, Focà A, Torti C Abstract Hepatitis C virus (HCV) infects around 71 million people worldwide and in 2018 it is still a major health problem. Since 2011, anti-HCV therapy with availability of direct-acting antiviral drugs has revolutionized the clinical response and paved the way to eradication strategies. However, despite the high rate of sustained virological response, treatment failure may occur in a limited percentage of patients, possibly due to resistance-associated substitutions (RASs), either em...
Source: Clinical and molecular hepatology - January 25, 2019 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Development and surveillance of hepatocellular carcinoma in patients with sustained virologic response after antiviral therapy for chronic hepatitis C.
Authors: Na SK, Song BC Abstract Hepatitis C virus (HCV) infection is a major risk factor for liver cirrhosis and hepatocellular carcinoma (HCC), and is a leading cause of liver-related deaths worldwide. Recently available direct-acting antiviral agent is very safe and highly effective (>95% sustained virologic response, SVR) against all genotypes of HCV. Achievement of SVR has been associated with a significant reduction of hepatic decompensation, development of HCC, and liver-related mortality. However, HCC risk is not eliminated even after SVR. The annual incidences of HCC in advanced fibrosis or cirrhosis ha...
Source: Clinical and molecular hepatology - January 23, 2019 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

How does hepatic steatosis affect the outcome of patients with chronic hepatitis B?
Authors: Yu JH, Lee JW PMID: 30661335 [PubMed - as supplied by publisher] (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - January 23, 2019 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Gadoxetic acid-enhanced magnetic resonance imaging: Hepatocellular carcinoma and mimickers.
This article reviews the pros and cons of HCC diagnosis with gadoxetic acid-enhanced MRI and discuss some clues in the radiological differentiation of HCC from HCC mimickers. PMID: 30661336 [PubMed - as supplied by publisher] (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - January 23, 2019 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Can hepatic steatosis really promote hepatitis B viral hepatocarcinogenesis? The jury is out on.
Authors: Kim W PMID: 30599476 [PubMed - as supplied by publisher] (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - January 3, 2019 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Endoscopic treatment or balloon-occluded retrograde transvenous obliteration is safe for patients with esophageal/gastric varices in Child-Pugh class C end-stage liver cirrhosis.
Authors: Chung JW PMID: 30572695 [PubMed - as supplied by publisher] (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - December 24, 2018 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Rehabilitation for social reintegration in liver transplant patients.
Authors: Kim JM PMID: 30531662 [PubMed - as supplied by publisher] (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - December 13, 2018 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Cirrhotic cardiomyopathy: An independent prognostic factor for cirrhotic patients.
Authors: Lee YB, Lee JH PMID: 30531663 [PubMed - as supplied by publisher] (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - December 13, 2018 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Biomarker microfibril-associated glycoprotein 4 for non-invasive diagnosis and therapeutic evaluation of hepatic fibrosis in patients with hepatitis C.
Authors: Eom YW, Baik SK PMID: 30531664 [PubMed - as supplied by publisher] (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - December 13, 2018 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Ombitasvir/paritaprevir/ritonavir+dasabuvir and ribavirin associated drug-induced liver injury and syndrome of inappropriate secretion of anti-diuretic hormone: A case report.
Authors: Kumar R, Hsiang JC, Tan J, Thurairajah PH PMID: 30509013 [PubMed - as supplied by publisher] (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - December 6, 2018 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Direct-acting antivirals-based therapy decreases hepatic fibrosis serum biomarker microfibrillar-associated protein 4 in hepatitis C patients.
Authors: Mölleken C, Ahrens M, Schlosser A, Dietz J, Eisenacher M, Meyer HE, Schmiegel W, Holmskov U, Sarrazin C, Sorensen GL, Sitek B, Bracht T Abstract Background/Aims: An estimated 80 million people worldwide are infected with viremic hepatitis C virus (HCV). Even after eradication of HCV with direct acting antivirals (DAAs), hepatic fibrosis remains a risk factor for hepatocarcinogenesis. Recently, we confirmed the applicability of microfibrillar-associated protein 4 (MFAP4) as a serum biomarker for the assessment of hepatic fibrosis. The aim of the present study was to assess the usefulness of MFAP4 as a ...
Source: Clinical and molecular hepatology - November 20, 2018 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Radiomics and radiogenomics of primary liver cancers.
Authors: Jeong WK, Jamshidi N, Felker ER, Raman SS, Lu DS Abstract Concurrent advancements in imaging and genomic biomarkers have created opportunities to identify non-invasive imaging surrogates of molecular phenotypes. In order to develop such imaging surrogates radiomics and radiogenomics/imaging genomics will be necessary; there has been consistent progress in these fields for primary liver cancers. In this article we evaluate the current status of the field specifically with regards to hepatocellular carcinoma and intrahepatic cholangiocarcinoma, highlighting some of the up and coming results that were present...
Source: Clinical and molecular hepatology - November 19, 2018 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Influence of hepatic steatosis on the outcomes of patients with chronic hepatitis B treated with entecavir and tenofovir.
Authors: Kim DS, Jeon MY, Lee HW, Kim BK, Park JY, Kim DY, Ahn SH, Han KH, Kim SU Abstract Background/Aims: The influence of hepatic steatosis (HS) on chronic hepatitis B (CHB) is unclear. We evaluated the influence of the degree of HS, assessed using the controlled attenuation parameter (CAP) of transient elastography (TE), on treatment outcomes in CHB patients initiated on antiviral therapy. Methods: A total of 334 patients who were initiated on entecavir or tenofovir between 2007 and 2016 with available TE results were recruited. Results: Of the total study population, 146 (43.7%) patients had HS (CAP>...
Source: Clinical and molecular hepatology - November 14, 2018 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Endoscopic treatment or balloon-occluded retrograde transvenous obliteration is safe for patients with esophageal/gastric varices in Child-Pugh class C end-stage liver cirrhosis.
Conclusions: The study demonstrated that patients with a CPS of up to 10 and less than 4.0 mg/dL of serum total bilirubin levels may not have a negative impact on prognosis after invasive treatment for esophageal/gastric varices despite their CP-C end-stage LC. PMID: 30408943 [PubMed - as supplied by publisher] (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - November 10, 2018 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Severe acute alcoholic hepatitis and liver transplant: A never-ending mournful story.
Authors: Obed A, Bashir A, Stern S, Jarrad A Abstract Severe acute alcoholic liver disease (SAAH) unresponsive to medical therapy shows one-year-mortality rates of up to 90%. Most transplant centers request six months of alcohol abstinence prior to transplantation, the so-called "6-month rule." This regulation is not based on strong evidence, repeatedly making it a topic of controversial debates. The majority of patients with SAAH will die before fulfilling the 6-month rule. Therefore, liver transplantation (LT) protocols are becoming more flexible towards the rigid abstinence regulation, especially conce...
Source: Clinical and molecular hepatology - October 27, 2018 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Association between hepatic steatosis and the development of hepatocellular carcinoma in patients with chronic hepatitis B.
Conclusions: Superimposed NAFLD was associated with a higher HCC risk in CHB patients. However, the association between steatosis per se and HCC risk was not evident after adjustment for metabolic factors. PMID: 30360031 [PubMed - as supplied by publisher] (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - October 27, 2018 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Fatigue and weakness hinder patient social reintegration after liver transplantation.
Conclusions: The data shows that as many as 50% of total patients returned to work after receiving LT. Fatigue and weakness were the most common complaints of the unemployed group, and resolving the causes of these symptoms may help to increase the employment rate. PMID: 30300990 [PubMed - as supplied by publisher] (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - October 13, 2018 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Pathologic differential diagnosis of metastatic carcinoma in the liver.
Authors: Park JH, Kim JH Abstract The liver is one of the most common sites to which malignancies preferentially metastasize. Although a substantial number of liver malignancies are primary tumors, including hepatocellular carcinoma and intrahepatic cholangiocarcinoma, the metastasis of carcinomas to the liver is relatively common and frequently encountered in clinical settings. Representative carcinomas that frequently metastasize to the liver include colorectal carcinoma, breast carcinoma, neuroendocrine tumors, lung carcinoma, and gastric carcinoma. The diagnostic confirmation of suspected metastatic lesions in ...
Source: Clinical and molecular hepatology - October 13, 2018 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Assessment of fibrotic burden among chronic hepatitis B virus-infected patients with normal transaminase level.
Authors: Jeon MY, Kim BK, Kim SU PMID: 30227702 [PubMed - as supplied by publisher] (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - September 21, 2018 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Does the old-fashioned sofosbuvir plus ribavirin treatment in genotype 2 chronic hepatitis C patients still works for Koreans?
Authors: Yeon JE PMID: 30200750 [PubMed - as supplied by publisher] (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - September 13, 2018 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Prognostic implications of trunk muscle mass in liver cirrhosis.
Authors: Han J, Kim W PMID: 30196650 [PubMed - as supplied by publisher] (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - September 11, 2018 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Combination of synbiotic and sitagliptin in nonalcoholic fatty liver disease: Is it better than sitagliptin alone?
Authors: Cho YK PMID: 30196651 [PubMed - as supplied by publisher] (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - September 11, 2018 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

VIEKIRA PAK associated drug-induced interstitial lung disease: Case series with systematic review of literature.
Authors: Wong YJ, Chew SY, Hsiang JC, Thurairajah PH, Kumar R, Teo EK, Gokhale RS, Noor IBM, Tan J PMID: 30184617 [PubMed - as supplied by publisher] (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - September 8, 2018 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Cardiac diastolic dysfunction predicts poor prognosis in patients with decompensated liver cirrhosis.
Authors: Lee SK, Song MJ, Kim SH, Ahn HJ Abstract Background/Aims: Left ventricular diastolic dysfunction (LVDD) is an early manifestation of cardiac dysfunction in patients with liver cirrhosis (LC). However, the effect of LVDD on survival has not been clarified, especially in decompensated LC. Methods: We prospectively enrolled 70 patients with decompensated LC, including ascites or variceal bleeding, at Daejeon St. Mary's Hospital from April 2013 to April 2015. The cardiac function of these patients was evaluated using 2D echocardiography with tissue Doppler imaging. The diagnosis of LVDD was based on the Am...
Source: Clinical and molecular hepatology - August 29, 2018 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Biochemical profile in an infant with neonatal hemochromatosis shows evidence of impairment of mitochondrial long-chain fatty acid oxidation.
Authors: Bastos KLM, Quaio CR, Lima FR, Araújo IM, Araújo CAT, Piazzon FB, Silva IDCGD, Benevides GN, Tannuri AC, Tannuri U, Azevedo RA, Kim CA PMID: 30149691 [PubMed - as supplied by publisher] (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - August 29, 2018 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

2017 KASL clinical practice guidelines management of hepatitis C: Treatment of chronic hepatitis C.
Authors: Korean Association for the Study of the Liver (KASL) PMID: 30092624 [PubMed - as supplied by publisher] (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - August 12, 2018 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Recent research trends and updates on nonalcoholic fatty liver disease.
Authors: Yoo JJ, Kim W, Kim MY, Jun DW, Kim SG, Yeon JE, Lee JW, Cho YK, Park SH, Sohn JH, Korean Association for the Study of the Liver (KASL)-Korea Nonalcoholic fatty liver Study Group (KNSG) Abstract Nonalcoholic fatty liver disease (NAFLD), together with metabolic syndrome and obesity, has shown a rapid increase in prevalence worldwide and is emerging as a major cause of chronic liver disease and liver transplantation. Among the various phenotypes of NAFLD, nonalcoholic steatohepatitis (NASH) is highly likely to progress to development of end-stage liver disease and cardiometabolic disease, resulting in liver-r...
Source: Clinical and molecular hepatology - August 9, 2018 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

The Association of leptin with severity of non-alcoholic fatty liver disease: A population-based study.
Authors: Rotundo L, Persaud A, Feurdean M, Ahlawat S, Kim HS Abstract Background/Aims: Leptin is associated with metabolic disorders, which predispose one to non-alcoholic fatty liver disease (NAFLD). The role of leptin in NAFLD pathogenesis is not fully understood. We aim to investigate the association between serum leptin level and severity of NAFLD using U.S. nationally representative data. Methods: Data were obtained from the United States Third National Health and Nutrition Examination Survey. NAFLD was defined by ultrasound detection and severity of hepatic steatosis in the absence of other liver diseases...
Source: Clinical and molecular hepatology - August 4, 2018 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

2017 clinical practice guidelines for liver cirrhosis: Ascites and related complications.
Authors: Korean Association for the Study of the Liver (KASL) PMID: 29991196 [PubMed - as supplied by publisher] (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - July 13, 2018 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Characterization and evaluation of liver fibrosis grade in patients with chronic hepatitis B virus infection and normal transaminases.
The objective of our study was to determine the epidemiological, laboratory, and serological characteristics of patients with chronic hepatitis B virus (HBV) infection and normal transaminases. The study also aimed to evaluate liver damage by measuring the liver fibrosis (LF) grade and to identify possible factors associated with the presence of fibrosis. Methods: A retrospective observational study was conducted in patients with chronic HBV infection and classified as inactive carriers or immune-tolerant. Epidemiological variables of age, sex, immigrant, alcohol consumption, and body mass index (BMI), as well as virol...
Source: Clinical and molecular hepatology - July 6, 2018 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Journal metrics of Clinical and Molecular Hepatology based on the Web of Science Core Collection.
Conclusions: Based on journal metrics, Clinical and Molecular Hepatology has succeeded in becoming a top-ranked international journal 8 years after changing its language policy to English-only. PMID: 29961305 [PubMed - in process] (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - July 3, 2018 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Effect of antiviral therapy in reducing perinatal transmission of hepatitis B virus and maternal outcomes after discontinuing them.
Conclusions: Antiviral treatment during late pregnancy effectively reduced MTCT. Long-term follow-up should be required in such cases. In addition, given that maternal biochemical flare occurred in 18% of mothers, re-administration of antiviral agents might be required. PMID: 29940720 [PubMed - as supplied by publisher] (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - June 28, 2018 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Transarterial embolization for the treatment of complicated liver hemangiomas: a report of two cases and review of the literature.
Authors: Kalogirou M, Chourmouzi D, Dedes I, Kiapidou S, Akriviadis E, Sinakos E PMID: 29886705 [PubMed - as supplied by publisher] (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - June 13, 2018 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Combined effects of synbiotic and sitagliptin versus sitagliptin alone in patients with nonalcoholic fatty liver disease.
Authors: Sayari S, Neishaboori H, Jameshorani M Abstract Background/Aims: Non-alcoholic fatty liver disease (NAFLD) is one of the most prevalent chronic liver diseases in recent years. The aim of this study was to evaluate the effects of sitagliptin with and without a synbiotic supplement in the treatment of patients with NAFLD. Methods: In total, 138 NAFLD patients aged 18-60 years were enrolled in the study. Patients were randomized to one of the following treatments for 16 weeks: Group I (n=68), sitagliptin 50 mg daily plus placebo (one capsule per day) or group II (n=70) sitagliptin 50 mg daily plus synbiot...
Source: Clinical and molecular hepatology - June 13, 2018 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Efficacy and safety of sofosbuvir plus ribavirin for Korean patients with hepatitis C virus genotype 2 infection: A retrospective multi-institutional study.
Conclusions: A 12-16 week treatment with sofosbuvir plus ribavirin is remarkably effective and well tolerated in Korean patients with chronic HCV genotype 2 infection. PMID: 29865774 [PubMed - as supplied by publisher] (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - June 6, 2018 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Recent update of the 2017 Korean Association for the Study of the Liver (KASL) treatment guidelines of chronic hepatitis C: comparison of guidelines from other continents, 2017 AASLD/IDSA and 2016 EASL.
Authors: Yeon JE Abstract The paradigm for the treatment of chronic hepatitis C (CHC) has been changed due to the development of direct acting antivirals (DAAs) of hepatitis C virus (HCV). The high sustained virologic response rate and ease of administration makes the DAAs approach ideal to contribute to the complete eradication of HCV. Currently, treatment options for individual patients vary depending on the genotype or subtype of HCV, presence or absence of liver cirrhosis, previous experience of antiviral treatment or resistance associated substitutions. Because of drug avalilability, cost-effectiveness, prefer...
Source: Clinical and molecular hepatology - May 4, 2018 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Clinical usefulness of psoas muscle thickness for the diagnosis of sarcopenia in patients with liver cirrhosis.
Authors: Gu DH, Kim MY, Seo YS, Kim SG, Lee HA, Kim TH, Jung YK, Kandemir A, Kim JH, An H, Yim HJ, Yeon JE, Byun KS, Um SH Abstract Background/Aims: The most widely used method for diagnosing sarcopenia is the skeletal muscle index (SMI). Several studies have suggested that psoas muscle thickness per height (PMTH) is also effective for detecting sarcopenia and predicting prognosis in patients with cirrhosis. The aim of this study was to evaluate the optimal cutoff values of PMTH for detecting sarcopenia in cirrhotic patients. Methods: All cirrhotic patients who underwent abdominal computed tomography (CT) scan ...
Source: Clinical and molecular hepatology - May 2, 2018 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research