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Letter to the editor of radiotherapy and oncology regarding the article esposito et al: Estimating dose delivery accuracy in stereotactic body radiation therapy: a review of in-vivo measurement methods.
PMID: 32653600 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 9, 2020 Category: Radiology Authors: Kos S Tags: Radiother Oncol Source Type: research

A deep learning MR-based radiomic nomogram may predict survival for nasopharyngeal carcinoma patients with stage T3N1M0.
Abstract PURPOSE: To estimate the prognostic value of deep learning (DL) magnetic resonance (MR)-based radiomics for stage T3N1M0 nasopharyngeal carcinoma (NPC) patients receiving induction chemotherapy (ICT) prior to concurrent chemoradiotherapy (CCRT). METHODS: A total of 638 stage T3N1M0 NPC patients (training cohort: n = 447; test cohort: n = 191) were enrolled and underwent MRI scans before receiving ICT+CCRT. From the pretreatment MR images, DL-based radiomic signatures were developed to predict disease-free survival (DFS) in an end-to-end way. Incorporating independent clinical prognostic parameters an...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 4, 2020 Category: Radiology Authors: Zhong LZ, Fang XL, Dong D, Peng H, Fang MJ, Huang CL, He BX, Lin L, Ma J, Tang LL, Tian J Tags: Radiother Oncol Source Type: research

4D CT analysis of organs at risk (OARs) in stereotactic radiotherapy.
Abstract Internal organs at risk volumes (IRV) represent the propagation of organs at risk (OARs) in 4DCT. Sixty consecutive patients that underwent 4DCT for thoracic stereotactic radiotherapy were analyzed and IRVs for heart, trachea, esophagus, bronchial tree, great vessels, and spinal cord were calculated. IRVs were then tested for the respect of dose constraints. IRVs were significantly bigger than standard OARs (p-value
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 2, 2020 Category: Radiology Authors: Nardone V, Maria Giugliano F, Reginelli A, Sangiovanni A, Mormile M, Iadanza L, Cappabianca S, Guida C Tags: Radiother Oncol Source Type: research

Measurement of circulating free DNA in squamous cell carcinoma of the anus and relation to risk factors and recurrence.
Spindler KL Abstract BACKGROUND: Measuring circulating-free-deoxyribonucleic-acid (cfDNA) has created a new framework for personalized treatment in oncology. The aim of this study was to analyze the relation between cfDNA and risk factors and outcome in squamous cell carcinoma of the anus (SCCA). METHODS: Patients treated with radiotherapy for localized SCCA were included in Aarhus, Denmark from 2016 -2019. Serum samples from baseline, during and after therapy, were measured for the level of cfDNA in copies per mL by a direct fluorescent assay. RESULTS: Eighty patients were included. Samples were availab...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 2, 2020 Category: Radiology Authors: Cecilie Lefèvre A, Kronborg C, Singers Sørensen B, Rasmus Palmelund Krag S, Serup-Hansen E, Garm Spindler KL Tags: Radiother Oncol Source Type: research

Prostate intrafraction motion during the preparation and delivery of MR-guided radiotherapy sessions on a 1.5T MR-Linac.
CONCLUSION: This is the first study to investigate prostate intrafraction motions during entire MR-guided RT sessions on an MR-Linac. We have shown that high quality 3D cine-MR imaging and prostate tracking during RT is feasible with beam-on. The clinically applied margins of 5 mm have proven to be sufficient for these treatments and may potentially be further reduced using intrafraction plan adaptation guided by cine-MR imaging. PMID: 32622779 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 2, 2020 Category: Radiology Authors: de Muinck Keizer DM, Kerkmeijer LGW, Willigenburg T, van Lier ALHMW, Hartogh MDD, van der Voort van Zyp JRN, de Groot-van Breugel EN, Raaymakers BW, Lagendijk JJW, de Boer JCJ Tags: Radiother Oncol Source Type: research

Impact of Invasive Nodal Staging on Regional and Distant Recurrence Rates after SBRT for Inoperable Stage I NSCLC.
CONCLUSIONS: In patients with early-stage NSCLC deemed node-negative by PET/CT, addition of INS did not appreciably alter patterns of failure or survival after definitive SBRT. This study does not question the established value of INS for equivocal or suspicious nodes. PMID: 32622780 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 2, 2020 Category: Radiology Authors: Kennedy WR, Samson PP, Gabani P, Nikitas J, Bradley JD, Roach MC, Robinson CG Tags: Radiother Oncol Source Type: research

Magnetic resonance-based synthetic computed tomography images generated using generative adversarial networks for nasopharyngeal carcinoma radiotherapy treatment planning.
CONCLUSION: Both cGAN and cycleGAN could swiftly generate accurate SCT volume images from MR images, with high dosimetric accuracy for NPC IMRT planning. cGAN was preferable if high-quality MR-CT image pairs were available. PMID: 32622781 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 2, 2020 Category: Radiology Authors: Peng Y, Chen S, Qin A, Chen M, Gao X, Liu Y, Miao J, Gu H, Zhao C, Deng X, Qi Z Tags: Radiother Oncol Source Type: research

Involved node radiation therapy in the combined modality treatment for early-stage Hodgkin lymphoma: Analysis of relapse location and long-term outcome.
CONCLUSIONS: Modern treatment with brief chemotherapy and limited radiotherapy provides excellent long-term disease control in ESHL. Neither bulk, high FDG-uptake, nor residual CT abnormality after chemotherapy could predict initially involved lymph nodes with a high risk of relapse. PMID: 32622782 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 2, 2020 Category: Radiology Authors: Nielsen K, Vestmoe Maraldo M, Kiil Berthelsen A, Loft A, de Nully Brown P, Richter Vogelius I, Meidahl Petersen P, Specht L Tags: Radiother Oncol Source Type: research

Letter to the editor regarding "lack of supporting data make the risks of a clinical trial of radiation therapy as a treatment for COVID-19 pneumonia unacceptable".
Letter to the editor regarding "lack of supporting data make the risks of a clinical trial of radiation therapy as a treatment for COVID-19 pneumonia unacceptable". Radiother Oncol. 2020 Jul 01;: Authors: Magrini SM, Katz MS, Tomasini D, Sasso G, Triggiani L, di Monale E Bastia MB, Spiazzi L PMID: 32621829 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 1, 2020 Category: Radiology Authors: Magrini SM, Katz MS, Tomasini D, Sasso G, Triggiani L, di Monale E Bastia MB, Spiazzi L Tags: Radiother Oncol Source Type: research

Prioritization on palliative radiotherapy during the COVID-19 pandemic (and beyond).
PMID: 32621830 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 1, 2020 Category: Radiology Authors: Francesco C, Stefania M, Antonietta GM, Vincenzo V Tags: Radiother Oncol Source Type: research

Letter to the editor regarding wei w et al.: "Experience of the hubei cancer hospital in wuhan, china".
Letter to the editor regarding wei w et al.: "Experience of the hubei cancer hospital in wuhan, china". Radiother Oncol. 2020 Jul 01;: Authors: Merlotti A, Taglianti RV, Melano A, Reali LGA, Petrucci R, Russi EG PMID: 32621831 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 1, 2020 Category: Radiology Authors: Merlotti A, Taglianti RV, Melano A, Reali LGA, Petrucci R, Russi EG Tags: Radiother Oncol Source Type: research

Hypofractionation in COVID-19 Radiotherapy: A Mix of Evidence Based Medicine and of Opportunities.
PMID: 32621832 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 1, 2020 Category: Radiology Authors: Portaluri M, Barba MC, Musio D, Tramacere F, Pati F, Bambace S Tags: Radiother Oncol Source Type: research

Cancer oligometastases heterogeneity: Standardizing nomenclature in regard to defining oligometastatic disease from a radiation oncology perspective: an ESTRO-ASTRO consensus document.
PMID: 32619454 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 30, 2020 Category: Radiology Authors: Boon IS, Yong TPTA, Boon CS Tags: Radiother Oncol Source Type: research

Does ADT benefit unfavourable intermediate risk prostate cancer patients treated with brachytherapy boost and external beam radiotherapy? A propensity-score matched analysis.
CONCLUSION: Short-term ADT increased BFFS in UIR prostate cancer patients treated with HDR-BT boost plus EBRT. PMID: 32619455 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 30, 2020 Category: Radiology Authors: Mendez LC, Martell K, Warner A, Tseng CL, Chung H, Loblaw A, Rodrigues GB, Morton G Tags: Radiother Oncol Source Type: research

Response to "Hypofractionated chemoradiotherapy for locally advanced non-small cell lung cancer: is split-dose chemotherapy safer than full dose chemotherapy?"
Response to "Hypofractionated chemoradiotherapy for locally advanced non-small cell lung cancer: is split-dose chemotherapy safer than full dose chemotherapy?" Radiother Oncol. 2020 Jun 27;: Authors: Kepka L, Socha J PMID: 32603673 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 27, 2020 Category: Radiology Authors: Kepka L, Socha J Tags: Radiother Oncol Source Type: research

Challenges in conducting large randomised control trials of palliative radiotherapy in head and neck cancer.
PMID: 32603674 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 27, 2020 Category: Radiology Authors: Shahid Iqbal M, Kovarik J, Kelly C Tags: Radiother Oncol Source Type: research

Augmenting the therapeutic window of radiotherapy: A perspective on molecularly targeted therapies and nanomaterials.
Abstract Radiation therapy is a cornerstone of modern cancer therapy alongside surgery, chemotherapy, and immunotherapy, with over half of all cancer patients receiving radiation therapy as part of their treatment regimen. Development of novel radiation sensitizers that can improve the therapeutic ratio of radiation are sought after, particularly for tumors at an elevated risk of local and regional recurrence such as locally-advanced lung, head and neck, and gastrointestinal tumors. This review discusses clinical strategies to enhance radiotherapy efficacy and decrease toxicity, hence, increasing the overall thera...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 26, 2020 Category: Radiology Authors: Reda M, Bagley AF, Zaidan HY, Yantasee W Tags: Radiother Oncol Source Type: research

Fibroblast Activation Protein (FAP) specific PET for advanced target volume delineation in Glioblastoma.
g S Abstract Fibroblast Activation Protein (FAP)-specific Positron Emission Tomography (PET) has shown promising results in various cancers. This pilot study compares FAP-specific PET to MRI for treatment planning in 13 Glioblastoma patients. The resulting incongruent volumes could provide additional information for radiotherapy or biopsy planning. PMID: 32598977 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 26, 2020 Category: Radiology Authors: Windisch P, Röhrich M, Regnery S, Tonndorf-Martini E, Held T, Lang K, Bernhardt D, Rieken S, Giesel F, Haberkorn U, Debus J, Adeberg S Tags: Radiother Oncol Source Type: research

Assessing the role of stereotactic body radiation therapy in a large cohort of patients with lymph node oligometastases: does it affect systemic treatment's intensification?
CONCLUSION: With the present analysis, we confirmed on a large cohort the benefit from SBRT on lymph node oligometastases in multidisciplinary management. Combination of SBRT with new systemic therapies, including immunotherapy and targeted therapy, should be investigated to reduce the risk of progression out of the field of irradiation. PMID: 32593644 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 25, 2020 Category: Radiology Authors: Franzese C, Badalamenti M, Comito T, Franceschini D, Clerici E, Navarria P, Loi M, D'agostino G, Baldaccini D, Chiola I, Reggiori G, Mancosu P, Tomatis S, Scorsetti M Tags: Radiother Oncol Source Type: research

Daily computed tomography image guidance: dosimetric advantages outweigh low-dose radiation exposure for treatment of mediastinal lymphoma.
Abstract CT-guided treatment delivery can improve target localization in mediastinal lymphoma patients treated with "butterfly" intensity-modulated radiotherapy and deep-inspiration breath hold. Although daily CT imaging adds additional radiation exposure, its use may be justified given the greater normal tissue sparing enabled by PTV margin reduction. PMID: 32593645 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 25, 2020 Category: Radiology Authors: Zhu LL, Martin RM, Gunther JR, Wong PF, Hancock D, Moreno AC, Dabaja BS, Pinnix CC Tags: Radiother Oncol Source Type: research

Long-term results of a protocol-based ultrasound-guided salvage brachytherapy as re-irradiation for local recurrent prostate cancer.
CONCLUSION: PDR salvage brachytherapy in local recurrent previously irradiated prostate cancer is efficient with low late toxicity. Salvage-brachytherapy represents a valuable therapeutic option for the treatment of previously irradiated locally recurrent prostate cancer. PMID: 32593646 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 25, 2020 Category: Radiology Authors: Schönle N, Strnad V, Lotter M, Kreppner S, Fietkau R Tags: Radiother Oncol Source Type: research

Letter to editor regarding Urban et al., FDG-PET/CT scan assessment of response 12 weeks post radical radiotherapy in oropharynx head and neck cancer: The impact of p16 status.
PMID: 32592891 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 24, 2020 Category: Radiology Authors: Rulach R, Zhou S, Paterson C Tags: Radiother Oncol Source Type: research

Metformin: (future) best friend of the radiation oncologist?
Abstract Several molecules are being investigated for their ability to enhance the anti-tumor effect of radiotherapy. The widely prescribed antidiabetic drug metformin has been suggested to possess anti-cancer activity; data indicate that metformin could also enhance radiation sensitivity. The purpose of this review is to summarize current knowledge on the specific effect of metformin in the field of RT, while also discussing the many unknowns that persist. Preclinical models point to multiple mechanisms involved in the radiosensitizing effects of metformin that are mainly linked to mitochondrial complex I inhibit...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 24, 2020 Category: Radiology Authors: Chevalier B, Pasquier D, Lartigau EF, Chargari C, Schernberg A, Jannin A, Mirabel X, Vantyghem MC, Escande A Tags: Radiother Oncol Source Type: research

BMI1-KLF4 axis deficiency improves responses to neoadjuvant concurrent chemoradiotherapy in patients with rectal cancer.
Abstract PURPOSE: Neoadjuvant concurrent chemoradiotherapy (CCRT) is a gold standard treatment for patients with stage II/III rectal cancer. B-cell-specific Moloney murine leukemia virus insertion site 1 (BMI1) is a member of the polycomb group of proteins that are involved in regulating gene expression. High levels of BMI1 have been demonstrated to contribute to the malignant phenotypes of several cancers; however, its relevance in rectal cancer treated with CCRT is largely unknown. METHODS AND MATERIALS: We used two patient cohorts to address the clinical relevance of BMI1 in human cancers. In addition, HT-...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 24, 2020 Category: Radiology Authors: Hsu YC, Luo CW, Huang WL, Wu CC, Chou CL, Chen CI, Chang SJ, Chai CY, Wang HC, Chen TY, Li CF, Pan MR Tags: Radiother Oncol Source Type: research

Patterns of practice for adaptive and real-time radiation therapy (POP-ART RT) part I: intra-fraction breathing motion management.
CONCLUSION: Sixty-eight percent of respondents used RRMM and 71% wished to implement RRMM for a new tumour site. The main barriers to implementation were human/financial resources and capacity on treatment machines. PMID: 32585236 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 22, 2020 Category: Radiology Authors: Anastasi G, Bertholet J, Poulsen P, Roggen T, Garibaldi C, Tilly N, Booth JT, Oelfke U, Heijmen B, Aznar MC Tags: Radiother Oncol Source Type: research

Patterns of practice for adaptive and real-time radiation therapy (POP-ART RT) part II: offline and online plan adaption for interfractional changes.
CONCLUSIONS: ART was used for a broad range of tumour sites, mainly with ad-hoc offline replanning and for a median of 3 tumour sites. There was a large interest in implementing ART for more tumour sites, mainly limited by human/material resources and technical limitations. Daily online replanning was primarily performed on MR-linacs. PMID: 32579998 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 21, 2020 Category: Radiology Authors: Bertholet J, Anastasi G, Noble D, Bel A, van Leeuwen R, Roggen T, Duchateau M, Pilskog S, Garibaldi C, Tilly N, García-Mollá R, Bonaque J, Oelfke U, Aznar MC, Heijmen B Tags: Radiother Oncol Source Type: research

Feasibility of patient specific quality assurance for proton therapy based on independent dose calculation and predicted outcomes.
CONCLUSIONS: We demonstrated a feasibility to substitute PSQAM with PSQAIDC. In addition, we showed that PSQAIDC results can be interpreted in clinically more relevant manner, for instance using TCP / NTCP. PMID: 32579999 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 21, 2020 Category: Radiology Authors: Meijers A, Marmitt GG, Ng Wei Siang K, van der Schaaf A, Knopf AC, Langendijk JA, Both S Tags: Radiother Oncol Source Type: research

Comparison of different methods for lung immobilization in an animal model.
CONCLUSION: In this model, HFJV at 200 min-1 was the best compromise between immobilization and gas exchange for sessions of 10-min duration. PMID: 32580000 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 21, 2020 Category: Radiology Authors: LoMauro A, Aliverti A, Joensen O, Karaca I, Nyström PW, Larsson A, Frykholm P, Sütterlin R Tags: Radiother Oncol Source Type: research

Radiotherapy target volume definition in newly diagnosed high grade glioma using 18F-FET PET imaging and multiparametric perfusion MRI: a prospective study (IMAGG).
k U Abstract PURPOSE: The aim of this study was to prospectively investigate tumor volume delineation by amino acid PET and multiparametric perfusion magnetic resonance imaging (MRI) in patients with newly diagnosed, untreated high grade glioma (HGG). MATERIALS AND METHODS: Thirty patients with histologically confirmed HGG underwent O-(2-[18F]-fluoroethyl)-l-tyrosine (18F-FET) positron emission tomography (PET), conventional Magnetic Resonance Imaging (MRI) as contrast-enhanced (CE) and fluid-attenuated inversion recovery (FLAIR) and multiparametric MRI as relative cerebral blood volume (rCBV) and permeabilit...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 21, 2020 Category: Radiology Authors: Dissaux G, Dissaux B, Kabbaj OE, Gujral DM, Pradier O, Salaün PY, Seizeur R, Bourhis D, Salem DB, Querellou S, Schick U Tags: Radiother Oncol Source Type: research

Methylation-associated silencing of miR-193b improves the radiotherapy sensitivity of esophageal cancer cells by targeting cyclin D1 in areas with zinc deficiency.
Abstract BACKGROUND: Although radiotherapy is an important treatment mode for esophageal cancer (EC), the outcome remains unsatisfactory due to radioresistance, and the key cause of radiotherapy resistance is a change in the cell cycle. Zinc deficiency (ZD) has a significant influence on the cell cycle, and this effect is a common phenomenon in areas with a high incidence of esophageal cancer. METHODS: Radioresistant sub-cell lines were established by exposing esophageal cancer cells to nine rounds of X-ray irradiation at a dose of 2 Gy. The cells were treated with a range of different concentrations of zinc ...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 21, 2020 Category: Radiology Authors: Jin J, Guo Y, Dong X, Liu J, He Y Tags: Radiother Oncol Source Type: research

RhoA/ROCK pathway inhibitor ameliorates erectile dysfunction induced by radiation therapy in rats.
In this study, we investigated whether RhoA/ROCK pathway inhibition by a specific inhibitor called Hydroxyfasudil (HF) can improve RiED in our well-established rat model. MATERIALS /METHODS: Male Sprague-Dawley rats were randomized to the following groups: sham-RT, HF-only, RT-only, and RT+HF. Rats were either exposed to a single dose of 25 Gy prostate-confined RT or a sham procedure. 10mg/kg HF or normal saline was injected intraperitoneally. Erectile function was evaluated by intracavernosal pressure (ICP) and mean arterial pressure (MAP) measurements at week 14 post-RT. Cavernous nerve (CN) injury was evaluated by ...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 18, 2020 Category: Radiology Authors: Mahmood J, Pandita R, Zhang A, Kamlapurkar S, Saeed A, Chen M, Staats PN, Shukla HD, Anvari A, Sawant A, Vujaskovic Z Tags: Radiother Oncol Source Type: research

Hypofractionated chemoradiotherapy for locally advanced non-small cell lung cancer: Is split-dose chemotherapy safer than full dose chemotherapy?
PMID: 32562737 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 17, 2020 Category: Radiology Authors: Iqbal MS, McMenemin R, Greystoke A Tags: Radiother Oncol Source Type: research

Effect of COVID-19 pandemic on practice in european radiation oncology centers.
Abstract ESTRO surveyed European radiation oncology department heads to evaluate the impact of COVID-19. Telemedicine was used in 78% of the departments, and 60% reported a decline in patient volume. Use of protective measures was implemented on a large scale, but shortages of personal protective equipment were present in more than half of the departments. PMID: 32544604 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 13, 2020 Category: Radiology Authors: Slotman BJ, Lievens Y, Poortmans P, Cremades V, Eichler T, Wakefield DV, Ricardi U Tags: Radiother Oncol Source Type: research

Saliva electrolyte analysis and xerostomia-related quality of life in nasopharyngeal carcinoma patients following intensity-modulated radiation therapy.
CONCLUSIONS: Our study revealed the change of saliva electrolytes and xerostomia-related quality of life in patients undergone IMRT for NPC. PMID: 32544605 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 13, 2020 Category: Radiology Authors: Lan X, Chan JYK, Pu JJ, Qiao W, Pang S, Yang WF, Wong KCW, Kwong DLW, Su YX Tags: Radiother Oncol Source Type: research

Delineation of whole heart and substructures in thoracic radiation therapy: National guidelines and contouring atlas by the danish multidisciplinary cancer groups.
CONCLUSION: National guidelines for contouring the heart and cardiac substructures were developed across relevant Danish Multidisciplinary Cancer Groups, where RT dose to the heart is of concern. The inter-observer contour overlap was best for the heart and chambers and decreased for smaller structures. PMID: 32544606 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 13, 2020 Category: Radiology Authors: Milo MLH, Offersen BV, Bechmann T, Diederichsen ACP, Hansen CR, Holtved E, Josipovic M, Lörincz T, Maraldo MV, Nielsen MH, Nordsmark M, Witt Nyström P, Pøhl M, Rose HK, Schytte T, Yates ES, Lorenzen EL Tags: Radiother Oncol Source Type: research

Changes in radiotherapy practice during COVID-19 outbreak in turkey: a report from the turkish society for radiation oncology.
PMID: 32544607 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 13, 2020 Category: Radiology Authors: Anacak Y, Onal C, Ozyigit G, Agaoglu F, Akboru H, Akyurek S, Gursel B, Igdem S, Yalman D, Yıldız F, Saglam EK Tags: Radiother Oncol Source Type: research

Adapting to the contemporary normal in cancer management and workflow during COVID-19 situation in the Philippines: Multi-cancer center collaborative approach.
PMID: 32544608 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 13, 2020 Category: Radiology Authors: Cruz MC, Flores JAS, Paule JR, Macalalad JM, Lacuesta AVA, Francisco MC, Agustin MARD, Banuelos GC, Sarmiento TS, Villegas FC, Tangco ED, Olvina MC, Aguilar CRP, Pusag CT, Enriquez KS, Lo KJB, Ramos JMF Tags: Radiother Oncol Source Type: research

The utility of multiparametric MRI to characterize hypoxic tumor subvolumes in comparison to FMISO PET/CT. Consequences for diagnosis and chemoradiation treatment planning in head and neck cancer.
CONCLUSION: MpMRI parameters differ significantly between hypoxic and non-hypoxic tumor regions, defined on FMISO-PET/CT as gold standard and might represent surrogate markers for hypoxia. These findings suggest that mpMRI may be useful in the future as a surrogate modality for hypoxia imaging in order to personalize CRT. PMID: 32544609 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 13, 2020 Category: Radiology Authors: Wiedenmann N, Grosu AL, Büchert M, Rischke HC, Ruf J, Bielak L, Majerus L, Rühle A, Bamberg F, Baltas D, Hennig J, Mix M, Bock M, Nicolay NH Tags: Radiother Oncol Source Type: research

A Deep Learning Risk Prediction Model for Overall Survival in Patients with Gastric Cancer: A Multicenter Study.
Abstract BACKGROUND AND PURPOSE: Risk prediction of overall survival (OS) is crucial for gastric cancer (GC) patients to assess the treatment programs and may guide personalized medicine. A novel deep learning (DL) model was proposed to predict the risk for OS based on computed tomography (CT) images. MATERIALS AND METHODS: We retrospectively collected 640 patients from three independent centers, which were divided into a training cohort (center 1 and center 2, n=518) and an external validation cohort (center 3, n=122). We developed a DL model based on the architecture of residual convolutional neural network...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 12, 2020 Category: Radiology Authors: Zhang L, Dong D, Zhang W, Hao X, Fang M, Wang S, Li W, Liu Z, Wang R, Zhou J, Tian J Tags: Radiother Oncol Source Type: research

Normal Tissue Complication Probability of Vertebral Compression Fracture after Stereotactic Body Radiotherapy for De Novo Spine Metastasis.
CONCLUSIONS: SBRT provides excellent tumor control for spinal metastases and is associated with low rate of VCF in our cohort. NTCP modeling suggests that the larger volume of spine receiving lower doses are more closely associated with post-SBRT VCF than high dose regions. Under current target delineation methods, common SBRT regimens such as 24Gy in 2 fractions or 27Gy in 3 fractions may be inherently associated with VCF risk of 10% or greater. Consensus contouring guidelines should be reevaluated to minimize the volume of irradiated spine in light of these new data. PMID: 32540335 [PubMed - as supplied by publisher...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 12, 2020 Category: Radiology Authors: Chen X, Gui C, Grimm J, Huang E, Kleinberg L, Lo L, Sciubba D, Khan M, Redmond KJ Tags: Radiother Oncol Source Type: research

Gross tumour volume delineation in anal cancer on T2-weighted and diffusion-weighted MRI - reproducibility between radiologists and radiation oncologists and impact of reader experience level and DWI image quality.
CONCLUSION: Overall interobserver agreement for anal cancer GTV delineation on MRI is good for both radiologists and radiation oncologists, regardless of experience level. Use of DWI did not improve agreement. DWI artefacts affecting GTV delineation occurred in almost half of the patients, which may severely limit the use of DWI for radiotherapy planning if no steps are undertaken to avoid them. PMID: 32540336 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 12, 2020 Category: Radiology Authors: Min LA, Vacher YJL, Dewit L, Donker M, Sofia C, van Triest B, Bos P, van Griethuysen JJW, Maas M, Beets-Tan RGH, Lambregts DMJ Tags: Radiother Oncol Source Type: research

Consolidation cetuximab after concurrent triplet radiochemotherapy + cetuximab in patients with advanced head and neck cancer: A randomized phase II study.
CONCLUSIONS: There was no evidence that consolidation cetuximab would improve the 2-year LRC rate. Prognostic biological and imaging markers could be identified for the overall patient cohort. Studies with larger patient numbers are needed to correlate biological and imaging markers. PMID: 32540337 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 12, 2020 Category: Radiology Authors: Riesterer O, Pruschy M, Bender S, Sharma A, Bogowicz M, Tanadini-Lang S, Stieb S, Bertogg K, Weber S, Ikenberg K, Huber G, Schmid S, Bredell M, Veit-Haibach P, Rordorf T, Held U, Glanzmann C, Studer G Tags: Radiother Oncol Source Type: research

A physicochemical model of reaction kinetics supports peroxyl radical recombination as the main determinant of the FLASH effect.
CONCLUSION: The model gives support to the reduction of ROO. lifetime as the main root of FLASH and compares favorably with published experimental results. We conclude that any process - in this case radical recombination - that shortens the lifetime or limits the radiolytic yield of ROO. is likely to protect normoxic tissues against the deleterious effects of radiation. PMID: 32534957 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 11, 2020 Category: Radiology Authors: Labarbe R, Hotoiu L, Barbier J, Favaudon V Tags: Radiother Oncol Source Type: research

Volume-dependent dose-response of the intestinal stem cell niche and lymphoid tissue.
CONCLUSION: Our findings present the first observation of a field-size dependent dose-response of the intestinal stem cell niche. Its regeneration process does apparently not rely on distant radiation-sensitive resources of the organism, such as the bone marrow. Yet, our observations suggest that the niche interacts with intact tissue in millimetres distance, leading to faster crypt regeneration. The field-size dependent dose-response of SILTs posits a role of the immune system on the dose-volume effect. PMID: 32534012 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Soc...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 10, 2020 Category: Radiology Authors: Bahn E, van Heerden M, Sachse KN, Gueulette J, Slabbert JP, Alber M, Shaw W Tags: Radiother Oncol Source Type: research

Patient-reported outcome measures (PROMs) in palliative radiotherapy.
PMID: 32531333 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 9, 2020 Category: Radiology Authors: Schuler T, Hruby G, Eade T Tags: Radiother Oncol Source Type: research

Integrating tumor and nodal radiomics to predict lymph node metastasis in gastric cancer.
CONCLUSION: Our proposed method presented good predictive performance and great potential for predicting LNM in GC. As a noninvasive preoperative prediction tool, it can be helpful for guiding the prognosis and treatment decision-making in GC patients. PMID: 32531334 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 9, 2020 Category: Radiology Authors: Yang J, Wu Q, Xu L, Wang Z, Su K, Liu R, Yen EA, Liu S, Qin J, Rong Y, Lu Y, Niu T Tags: Radiother Oncol Source Type: research

The risk of radiation-associated heart disease comes from many factors; the chain is as strong as the weakest link.
PMID: 32531335 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 9, 2020 Category: Radiology Authors: Nordsmark M, Offersen BV Tags: Radiother Oncol Source Type: research

Response to Schuler et al. Patient-reported outcome measures (PROMs) in Palliative Radiotherapy.
PMID: 32531336 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 9, 2020 Category: Radiology Authors: Oldenburger E, Haustermans K Tags: Radiother Oncol Source Type: research

Predicting patient specific Pareto fronts from patient anatomy only.
CONCLUSIONS: We demonstrate the feasibility of fast, accurate predictions of the patient-specific PF for prostate cancer patients based only on delineations of PTV, rectum and body. PMID: 32526316 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 8, 2020 Category: Radiology Authors: van der Bijl E, Wang Y, Janssen T, Petit S Tags: Radiother Oncol Source Type: research

Interaction between lymphopenia, radiotherapy technique, dosimetry, and survival outcomes in lung cancer patients receiving combined immunotherapy and radiotherapy.
Abstract AIM: Immune function (e.g. absolute lymphocyte count (ALC)) and modifiable predictors thereof (e.g. volume of the heart/lungs receiving low-dose radiation) impact outcomes of cancer patients, but this has not been well-studied in the immunotherapy era. This investigation of metastatic lung cancer assessed the interaction of dosimetric parameters (e.g. lung/heart V5), radiotherapy technique (e.g. stereotactic (SBRT) or traditional radiotherapy), lymphopenia, and survival outcomes. METHODS: Patients were collected from three institutional phase I/II trials of combined immunotherapy and lung irradiation...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 7, 2020 Category: Radiology Authors: Chen D, Patel RR, Verma V, Ramapriyan R, Barsoumian HB, Cortez MA, Welsh JW Tags: Radiother Oncol Source Type: research