Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology RSS feedThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Acute patient-reported intestinal toxicity in whole pelvis IMRT for prostate cancer: bowel dose-volume effect quantification in a multicentric cohort study
Radiother Oncol. 2021 Feb 24:S0167-8140(21)06089-8. doi: 10.1016/j.radonc.2021.02.026. Online ahead of print.ABSTRACTBACKGROUND AND PURPOSE: To assess bowel dose-volume relationships for acute patient-reported intestinal symptoms of patients treated with whole-pelvis intensity-modulated radiotherapy (WPRT) for prostate cancer.MATERIALS AND METHODS: Complete data of 415 patients enrolled in a multi institute, prospective trial (#NCT02803086) treated with radical (31%), adjuvant (33%) and salvage (36%) intent at a median dose to pelvic nodes/lymph-nodal area of 53Gy were available. The most severe changes between baseline an...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 27, 2021 Category: Radiology Authors: Andrea Bresolin Adriana Faiella Elisabetta Garibaldi Fernando Munoz Domenico Cante Vittorio Vavassori Justina Magdalena Waskiewicz Giuseppe Girelli Barbara Avuzzi Elisa Villa Alessandro Magli Barbara Noris Chiorda Marco Gatti Letizia Ferella Angelo Maggio Source Type: research

Value of functional in-vivo endpoints in preclinical radiation research
CONCLUSIONS: GD/Gy with at least two dose groups correlates with TCD50, but cannot replace the latter as the goldstandard.PMID:33639191 | DOI:10.1016/j.radonc.2021.02.024 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 27, 2021 Category: Radiology Authors: Berit Kummer Steffen L öck Kristin Gurtner Nadine Hermann Ala Yaromina Wolfgang Eicheler Michael Baumann Mechthild Krause Christina Jentsch Source Type: research

Ultra-fractionated radiotherapy for low- and intermediate risk prostate cancer: High-dose-rate brachytherapy vs stereotactic ablative radiotherapy
Radiother Oncol. 2021 Feb 24:S0167-8140(21)06091-6. doi: 10.1016/j.radonc.2021.02.028. Online ahead of print.ABSTRACTPURPOSE: To compare the biochemical control rates (BCRs), late gastrointestinal (GI) and genitourinary (GU) toxicities in patients with low- and intermediate risk prostate cancer (PCa) treated with high-dose-rate brachytherapy (HDR BT) of 19Gy/1 fraction, 26Gy/2 fractions, or stereotactic ablative radiotherapy (SABR) of 36.25Gy/5 fractions.METHODS AND MATERIALS: Between August 2008 and December 2017, patients with low- and intermediate risk PCa who received single dose or 2-fraction HDR BT, or 5-fraction SAB...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 27, 2021 Category: Radiology Authors: Yat Man Tsang Hannah Tharmalingam Katherine Belessiotis-Richards Shreya Armstrong Peter Ostler Robert Hughes Roberto Alonzi Peter J Hoskin Source Type: research

Acute patient-reported intestinal toxicity in whole pelvis IMRT for prostate cancer: bowel dose-volume effect quantification in a multicentric cohort study
Radiother Oncol. 2021 Feb 24:S0167-8140(21)06089-8. doi: 10.1016/j.radonc.2021.02.026. Online ahead of print.ABSTRACTBACKGROUND AND PURPOSE: To assess bowel dose-volume relationships for acute patient-reported intestinal symptoms of patients treated with whole-pelvis intensity-modulated radiotherapy (WPRT) for prostate cancer.MATERIALS AND METHODS: Complete data of 415 patients enrolled in a multi institute, prospective trial (#NCT02803086) treated with radical (31%), adjuvant (33%) and salvage (36%) intent at a median dose to pelvic nodes/lymph-nodal area of 53Gy were available. The most severe changes between baseline an...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 27, 2021 Category: Radiology Authors: Andrea Bresolin Adriana Faiella Elisabetta Garibaldi Fernando Munoz Domenico Cante Vittorio Vavassori Justina Magdalena Waskiewicz Giuseppe Girelli Barbara Avuzzi Elisa Villa Alessandro Magli Barbara Noris Chiorda Marco Gatti Letizia Ferella Angelo Maggio Source Type: research

Value of functional in-vivo endpoints in preclinical radiation research
CONCLUSIONS: GD/Gy with at least two dose groups correlates with TCD50, but cannot replace the latter as the goldstandard.PMID:33639191 | DOI:10.1016/j.radonc.2021.02.024 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 27, 2021 Category: Radiology Authors: Berit Kummer Steffen L öck Kristin Gurtner Nadine Hermann Ala Yaromina Wolfgang Eicheler Michael Baumann Mechthild Krause Christina Jentsch Source Type: research

Ultra-fractionated radiotherapy for low- and intermediate risk prostate cancer: High-dose-rate brachytherapy vs stereotactic ablative radiotherapy
Radiother Oncol. 2021 Feb 24:S0167-8140(21)06091-6. doi: 10.1016/j.radonc.2021.02.028. Online ahead of print.ABSTRACTPURPOSE: To compare the biochemical control rates (BCRs), late gastrointestinal (GI) and genitourinary (GU) toxicities in patients with low- and intermediate risk prostate cancer (PCa) treated with high-dose-rate brachytherapy (HDR BT) of 19Gy/1 fraction, 26Gy/2 fractions, or stereotactic ablative radiotherapy (SABR) of 36.25Gy/5 fractions.METHODS AND MATERIALS: Between August 2008 and December 2017, patients with low- and intermediate risk PCa who received single dose or 2-fraction HDR BT, or 5-fraction SAB...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 27, 2021 Category: Radiology Authors: Yat Man Tsang Hannah Tharmalingam Katherine Belessiotis-Richards Shreya Armstrong Peter Ostler Robert Hughes Roberto Alonzi Peter J Hoskin Source Type: research

What is the role of the subventricular zone in radiotherapy of glioblastoma patients?
In this study, we retrospectively examined the relationship of SVZ irradiation dose and survival in a large, homogeneous GBM patient cohort.MATERIALS AND METHODS: We included 200 GBM patients who had been treated at our institution with trimodal therapy (surgery, radiotherapy and chemotherapy) between 2009 and 2020. The SVZ was delineated, and dose-volume histograms were calculated and extracted. Tumors were classified according to their contact with the SVZ. The Kaplan-Meier method was used for survival analysis, and univariable and multivariable Cox regression (MVA) were used to determine prognostic effects on progressio...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 26, 2021 Category: Radiology Authors: Katja Bender Malte Tr äger Helena Wahner Julia Onken Michael Scheel Marcus Beck Felix Ehret Volker Budach David Kaul Source Type: research

An evaluation of MR based deep learning auto-contouring for planning head and neck radiotherapy
CONCLUSION: A deep learning MR auto-contouring model shows promise for OAR auto-contouring with statistically improved performance vs a CT based model. Performance is affected by the method of MR acquisition and further work is needed to improve its use with MRL images.PMID:33636229 | DOI:10.1016/j.radonc.2021.02.018 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 26, 2021 Category: Radiology Authors: C Hague A McPartlin L W Lee C Hughes D Mullan W Beasley A Green G Price P Whitehurst N Slevin M van Herk C West R Chuter Source Type: research

Intrafraction motion monitoring to determine PTV margins in early stage breast cancer patients receiving neoadjuvant partial breast SABR
CONCLUSION: Our results suggest that a 5mm PTV margin is sufficient for the I/S and A/P directions if a lateral kV image is acquired immediately before treatment. For the L/R direction, either further immobilization or a larger margin is required.PMID:33636230 | DOI:10.1016/j.radonc.2021.02.021 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 26, 2021 Category: Radiology Authors: Matthew Mouawad Owen Lailey Per Poulsen Melissa O'Neil Muriel Brackstone Michael Lock Brian Yaremko Olga Shmuilovich Anat Kornecki Ilanit Ben Nachum Giulio Muscedere Kalan Lynn Scott Karnas Frank S Prato R Terry Thompson Stewart Gaede Source Type: research

Determining the incidence of interstitial pneumonitis and chronic kidney disease following full intensity haemopoetic stem cell transplant conditioned using a forward-planned intensity modulated total body irradiation technique
CONCLUSION: FP IMRT TBI, reducing dose to the lungs and kidneys, has lower rates of idiopathic IP and CKD compared to the literature. This technique is safe and effective conditioning for full intensity HSCT.PMID:33636231 | DOI:10.1016/j.radonc.2021.02.020 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 26, 2021 Category: Radiology Authors: E Durie E Nicholson C Anthias E M Dunne M Potter M Ethell C Messiou J Brennan S Eagle J Talbot G Smyth W Ingram F Saran H Mandeville Source Type: research

Adaptive intensity-modulated radiotherapy with simultaneous integrated boost for stage III non-small cell lung cancer: Is a routine adaptation beneficial?
CONCLUSIONS: We demonstrated that the routinely adaptive SIB-IMRT strategy could significantly reduce the dose to surrounding normal tissues, potentially lower the associated acute RP and RE, without increasing the risk of tumor recurrences.PMID:33636232 | DOI:10.1016/j.radonc.2021.02.019 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 26, 2021 Category: Radiology Authors: Yinnan Meng Wei Luo Hailing Xu Wei Wang Suna Zhou Xingni Tang Zihong Li Chao Zhou Haihua Yang Source Type: research

< sup > 68 < /sup > Ga-fibroblast activation protein inhibitor PET/CT on gross tumour volume delineation for radiotherapy planning of oesophageal cancer
CONCLUSION: The 68Ga-FAPI PET/CT methodology showed favourable tumour-to-background contrast in oesophageal cancer and might provide additional information for target volume delineation and help avoid tumour geographic misses.PMID:33621587 | DOI:10.1016/j.radonc.2021.02.015 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 23, 2021 Category: Radiology Authors: Liang Zhao Shanyu Chen Sijia Chen Yizhen Pang Yaqing Dai Shenping Hu Li'e Lin Lirong Fu Long Sun Hua Wu Haojun Chen Qin Lin Source Type: research

Progressive muscle loss is an independent predictor for survival in locally advanced oral cavity cancer: A longitudinal study
Radiother Oncol. 2021 Feb 20:S0167-8140(21)06077-1. doi: 10.1016/j.radonc.2021.02.014. Online ahead of print.ABSTRACTBACKGROUND AND PURPOSE: To investigate the association between progressive muscle loss and survival outcomes of patients with advanced-stage oral squamous cell carcinoma (OSCC) undergoing surgery and adjuvant (chemo)radiotherapy.METHODS: We analyzed the computed tomography (CT) scans of 155 patients with stage III-IVB OSCC at baseline, at simulation CT for radiotherapy, and at 3- and 9-months post-treatment. Skeletal muscle index (SMI) was measured using CT at the C3 vertebral level. The predictors of overal...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 23, 2021 Category: Radiology Authors: Jie Lee Shih-Hua Liu John Chun-Hao Chen Yi-Shing Leu Chung-Ji Liu Yu-Jen Chen Source Type: research

< sup > 68 < /sup > Ga-fibroblast activation protein inhibitor PET/CT on gross tumour volume delineation for radiotherapy planning of oesophageal cancer
CONCLUSION: The 68Ga-FAPI PET/CT methodology showed favourable tumour-to-background contrast in oesophageal cancer and might provide additional information for target volume delineation and help avoid tumour geographic misses.PMID:33621587 | DOI:10.1016/j.radonc.2021.02.015 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 23, 2021 Category: Radiology Authors: Liang Zhao Shanyu Chen Sijia Chen Yizhen Pang Yaqing Dai Shenping Hu Li'e Lin Lirong Fu Long Sun Hua Wu Haojun Chen Qin Lin Source Type: research

Progressive muscle loss is an independent predictor for survival in locally advanced oral cavity cancer: A longitudinal study
Radiother Oncol. 2021 Feb 20:S0167-8140(21)06077-1. doi: 10.1016/j.radonc.2021.02.014. Online ahead of print.ABSTRACTBACKGROUND AND PURPOSE: To investigate the association between progressive muscle loss and survival outcomes of patients with advanced-stage oral squamous cell carcinoma (OSCC) undergoing surgery and adjuvant (chemo)radiotherapy.METHODS: We analyzed the computed tomography (CT) scans of 155 patients with stage III-IVB OSCC at baseline, at simulation CT for radiotherapy, and at 3- and 9-months post-treatment. Skeletal muscle index (SMI) was measured using CT at the C3 vertebral level. The predictors of overal...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 23, 2021 Category: Radiology Authors: Jie Lee Shih-Hua Liu John Chun-Hao Chen Yi-Shing Leu Chung-Ji Liu Yu-Jen Chen Source Type: research

< sup > 68 < /sup > Ga-fibroblast activation protein inhibitor PET/CT on gross tumour volume delineation for radiotherapy planning of oesophageal cancer
CONCLUSION: The 68Ga-FAPI PET/CT methodology showed favourable tumour-to-background contrast in oesophageal cancer and might provide additional information for target volume delineation and help avoid tumour geographic misses.PMID:33621587 | DOI:10.1016/j.radonc.2021.02.015 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 23, 2021 Category: Radiology Authors: Liang Zhao Shanyu Chen Sijia Chen Yizhen Pang Yaqing Dai Shenping Hu Li'e Lin Lirong Fu Long Sun Hua Wu Haojun Chen Qin Lin Source Type: research

Progressive muscle loss is an independent predictor for survival in locally advanced oral cavity cancer: A longitudinal study
Radiother Oncol. 2021 Feb 20:S0167-8140(21)06077-1. doi: 10.1016/j.radonc.2021.02.014. Online ahead of print.ABSTRACTBACKGROUND AND PURPOSE: To investigate the association between progressive muscle loss and survival outcomes of patients with advanced-stage oral squamous cell carcinoma (OSCC) undergoing surgery and adjuvant (chemo)radiotherapy.METHODS: We analyzed the computed tomography (CT) scans of 155 patients with stage III-IVB OSCC at baseline, at simulation CT for radiotherapy, and at 3- and 9-months post-treatment. Skeletal muscle index (SMI) was measured using CT at the C3 vertebral level. The predictors of overal...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 23, 2021 Category: Radiology Authors: Jie Lee Shih-Hua Liu John Chun-Hao Chen Yi-Shing Leu Chung-Ji Liu Yu-Jen Chen Source Type: research

< sup > 68 < /sup > Ga-fibroblast activation protein inhibitor PET/CT on gross tumour volume delineation for radiotherapy planning of oesophageal cancer
CONCLUSION: The 68Ga-FAPI PET/CT methodology showed favourable tumour-to-background contrast in oesophageal cancer and might provide additional information for target volume delineation and help avoid tumour geographic misses.PMID:33621587 | DOI:10.1016/j.radonc.2021.02.015 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 23, 2021 Category: Radiology Authors: Liang Zhao Shanyu Chen Sijia Chen Yizhen Pang Yaqing Dai Shenping Hu Li'e Lin Lirong Fu Long Sun Hua Wu Haojun Chen Qin Lin Source Type: research

Progressive muscle loss is an independent predictor for survival in locally advanced oral cavity cancer: A longitudinal study
Radiother Oncol. 2021 Feb 20:S0167-8140(21)06077-1. doi: 10.1016/j.radonc.2021.02.014. Online ahead of print.ABSTRACTBACKGROUND AND PURPOSE: To investigate the association between progressive muscle loss and survival outcomes of patients with advanced-stage oral squamous cell carcinoma (OSCC) undergoing surgery and adjuvant (chemo)radiotherapy.METHODS: We analyzed the computed tomography (CT) scans of 155 patients with stage III-IVB OSCC at baseline, at simulation CT for radiotherapy, and at 3- and 9-months post-treatment. Skeletal muscle index (SMI) was measured using CT at the C3 vertebral level. The predictors of overal...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 23, 2021 Category: Radiology Authors: Jie Lee Shih-Hua Liu John Chun-Hao Chen Yi-Shing Leu Chung-Ji Liu Yu-Jen Chen Source Type: research

Two-year toxicity of simultaneous integrated boost in hypofractionated prone breast cancer irradiation: comparison with sequential boost in a randomized trial
CONCLUSION: There is no indication that a SIB leads to an excess in toxicity or worse cosmetic outcome at 2 years.PMID:33617910 | DOI:10.1016/j.radonc.2021.02.010 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 22, 2021 Category: Radiology Authors: Hans Van Hulle Eline Desaunois Vincent Vakaet Leen Paelinck Max Schoepen Giselle Post Annick Van Greveling Bruno Speleers Marc Mareel Wilfried De Neve Chris Monten Pieter Deseyne Liv Veldeman Source Type: research

Relapse pattern and quality of life in patients with localized basal ganglia germinoma receiving focal radiotherapy, whole-brain radiotherapy, or craniospinal irradiation
Radiother Oncol. 2021 Feb 18:S0167-8140(21)06069-2. doi: 10.1016/j.radonc.2021.02.009. Online ahead of print.ABSTRACTBACKGROUND AND PURPOSE: The optimal target volume in localized basal ganglia (BG) germinoma is still undetermined. Thus, based on the relapse pattern and health-related quality of life (HRQOL), we evaluated three target volumes.MATERIAL AND METHODS: The clinical data of 161 patients with localized BG germinoma were included in this retrospective study. Relapse status and relapse sites after treatment were explored. HRQOL was evaluated using the Pediatric Quality of Life Inventory 4.0 (PedsQL 4.0) (≤15 yea...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 21, 2021 Category: Radiology Authors: Bo Li Jin Feng Li Chen Youqi Li Jiayi Wang Wenyi Lv Yanong Li Yanwei Liu Shuai Liu Shiqi Luo Xiaoguang Qiu Source Type: research

Survival after palliative radiation therapy for cancer: the METSSS model
CONCLUSION: We created a predictive nomogram for survival of patients receiving palliative radiotherapy during their first course of treatment (named METSSS), based on Metastases location, Elderly (>65 years), Tumor primary, Sex, Sickness/comorbidity, and Site of radiotherapy.PMID:33610623 | DOI:10.1016/j.radonc.2021.02.011 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 21, 2021 Category: Radiology Authors: Nicholas G Zaorsky Menglu Liang Rutu Patel Christine Lin Leila T Tchelebi Kristina B Newport Edward J Fox Ming Wang Source Type: research

Local control and postponement of systemic therapy after modest dose radiotherapy in oligometastatic myxoid liposarcomas
CONCLUSIONS: This trial suggests that 36Gy could possibly be effective to achieve local control, postpone systemic therapy and reduce symptoms in oMLS. Given the minimal toxicity this treatment could be reasonably considered in oMLS.PMID:33610624 | DOI:10.1016/j.radonc.2021.02.013 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 21, 2021 Category: Radiology Authors: Jules Lansu Winan J van Houdt Kirsten van Langevelde Piet L A van den Ende Winette T A van der Graaf Yvonne Schrage Hester van Boven Astrid N Scholten Rick L Haas Source Type: research

Vision loss following high-dose proton-based radiotherapy for skull-base chordoma and chondrosarcoma
We report the incidence of vision loss following high-dose conformal proton-based radiotherapy.MATERIALS AND METHODS: We reviewed patients with skull-base chordoma or chondrosarcoma treated with proton-based therapy between 2007 and 2018. We analyzed 148 patients and 283 individual eyes with functional vision at baseline who received a minimum 30GyRBE to 0.1cm3 of the anterior optic pathway. Eyes were classified as "functionally blind" if visual acuity was 20/200 or worse. Kaplan-Meier and normal tissue complication probability modeling were used to establish the relationship between radiation dose and risk of fu...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 21, 2021 Category: Radiology Authors: Alexandra N De Leo Adam L Holtzman M W Ho Christopher G Morris Michael S Rutenberg Ronny L Rotondo James E Bates Daniel J Indelicato Dinesh Rao Mohammad Asa Hasan William M Mendenhall Source Type: research

Head and Neck Imaging Surveillance Strategy for HPV-positive Oropharyngeal Carcinoma Following Definitive (Chemo)Radiotherapy
CONCLUSIONS: Pattern of HN imaging utilization for surveillance varied significantly among clinicians. Imaging surveillance reduces the need for ND. However, routine HN-CT/MR surveillance without clinical symptoms/signs does not demonstrate proven value in identifying locoregional failure or toxicity. Radiologic "residual" LNs without adverse features are common. If two subsequent follow-up scans demonstrate stable/regressing radiologic "residual" LNs, clinical surveillance without further imaging appears to be safe in this population.PMID:33600871 | DOI:10.1016/j.radonc.2021.02.005 (Source: Radiotherap...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 18, 2021 Category: Radiology Authors: Erin T Wong Shao Hui Huang Brian O'Sullivan Vincent Persaud Jie Su John Waldron David P Goldstein John de Almeida Jolie Ringash John Kim Andrew Hope Scott Bratman John Cho Meredith Giuliani Ali Hosni Anna Spreafico Aaron Hansen Li Tong Wei Xu Eugene Yu Source Type: research

Prognostic factors of Colorectal Cancer patients with Brain Metastases
CONCLUSIONS: ECOG performance status, number of BM and number of chemotherapy lines are the most relevant factors in the management of patients with BM from CRC.PMID:33600872 | DOI:10.1016/j.radonc.2021.02.006 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 18, 2021 Category: Radiology Authors: Pauline Roussille Marie Auvray Damien Vansteene Thierry Lecomte Eug énie Rigault Marianne Maillet Christophe Locher Marie Dior Vincent Hautefeuille Pascal Artru May Mabro Yann Touchefeu Lysiane Marthey Val érie Moulin Samy Louafi C édric Lecaille Romai Source Type: research

Effectiveness of fractionated carbon ion treatments in three rat prostate tumors differing in growth rate, differentiation and hypoxia
CONCLUSION: 12C-ions reduce the radiation response heterogeneity between the three tumor sublines as well as within each subline relative to photon treatments, independently of fractionation. The dose dependence of the RBE varies between tumors of different histology. The results support the use of hypofractionated carbon ion treatments in radioresistant tumors.PMID:33587966 | DOI:10.1016/j.radonc.2021.01.038 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 15, 2021 Category: Radiology Authors: Christin Glowa Peter Peschke Stephan Brons J ürgen Debus Christian P Karger Source Type: research

Evaluation of Interim MRI Changes During Limited-Field Radiation Therapy for Glioblastoma and Implications for Treatment Planning
CONCLUSIONS: Initial CTV margin of 15 mm followed by a boost CTV margin of 7 mm is a reasonable approach for LFRT of GBM. Omitting routine inclusion of T2 abnormality from GTV delineation may not jeopardize disease control.PMID:33587967 | DOI:10.1016/j.radonc.2021.01.040 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 15, 2021 Category: Radiology Authors: Comron Hassanzadeh Soumon Rudra Sirui Ma Randall Brenneman Yi Huang Lauren Henke Christopher Abraham Jian Campian Christina Tsien Jiayi Huang Source Type: research

Individual patient data meta-analysis of prophylactic cranial irradiation in locally advanced non-small cell lung cancer
CONCLUSION: No OS benefit by PCI was observed, but PCI prolonged the progression-free survival and BM-free survival at an increased risk of late memory impairment and fatigue.PMID:33587968 | DOI:10.1016/j.radonc.2021.02.002 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 15, 2021 Category: Radiology Authors: Willem J A Witlox Bram L T Ramaekers Benjamin Lacas Cecile Le Pechoux Jean-Pierre Pignon Alexander Sun Si-Yu Wang Chen Hu Mary Redman Vincent van der Noort Ning Li Matthias Guckenberger Harm van Tinteren Harry J M Groen Manuela A Joore Dirk K M De Ruyssch Source Type: research

The primary site of head and neck squamous cell carcinoma predicts survival benefits of EGFR inhibitors: a systematic review and meta-analysis
Radiother Oncol. 2021 Feb 12:S0167-8140(21)06047-3. doi: 10.1016/j.radonc.2021.02.001. Online ahead of print.ABSTRACTBACKGROUND AND PURPOSE: To assess the survival benefits associated with epidermal growth factor receptor (EGFR) inhibitors in head and neck squamous cell carcinoma (HNSCC) according to the primary site.MATERIALS AND METHODS: A systematic review and meta-analysis were conducted for randomized phase III trials comparing treatment with or without EGFR inhibitors in locoregionally advanced, recurrent, or metastatic HNSCC. The primary and secondary endpoints were overall survival (OS) and progression-free surviva...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 15, 2021 Category: Radiology Authors: Deheng Nie Xin Wang Meiting Sun Zhenbang Feng Fengli Pei Wenhui Liu Zonghan Wang Fujun Han Source Type: research

Electron dose rate and oxygen depletion protect zebrafish embryos from radiation damage
CONCLUSION: The Flash experiment at ELBE showed that the zebrafish embryo model is appropriate for studying the radiobiological response of high dose rate irradiation. The applied high pulse dose rate was confirmed as important beam parameter as well as the pivotal role of pO2 during irradiation.PMID:33587970 | DOI:10.1016/j.radonc.2021.02.003 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 15, 2021 Category: Radiology Authors: J örg Pawelke Michael Brand Stefan Hans Katalin Hidegh éty Leonhard Karsch Elisabeth Lessmann Steffen L öck Michael Sch ürer Em ília Rita Szabó Elke Beyreuther Source Type: research

Predictors for Post-treatment Biopsy Outcomes after Prostate Stereotactic Body Radiotherapy
Radiother Oncol. 2021 Feb 12:S0167-8140(21)06057-6. doi: 10.1016/j.radonc.2021.02.008. Online ahead of print.ABSTRACTPURPOSE: To investigate predictors associated with post-treatment biopsy outcomes after stereotactic body radiotherapy (SBRT) for localized prostate cancer.MATERIALS AND METHODS: 257 patients treated with prostate SBRT to dose levels of 32.5 Gy to ≥40 Gy in 5-6 fractions underwent a post-treatment biopsy performed approximately two years after treatment to evaluate local control status. 73 had% intermediate-risk disease (n=187) and the remaining 17% (n=43) and 10% (n=27) had low-risk and high-risk disease...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 15, 2021 Category: Radiology Authors: Michael J Zelefsky Debra A Goldman Margaret Hopkins Attapol Pinitpatcharalert Sean McBride Daniel Gorovets Behfar Ehdaie Samson W Fine Victor E Reuter Neelam Tyagi Laura Happersett Achiraya Teyateeti Zhigang Zhang Marisa A Kollmeier Source Type: research

Diffusion weighted imaging in submandibular gland sparing helical tomotherapy for nasopharyngeal carcinoma
Radiother Oncol. 2021 Feb 12:S0167-8140(21)06050-3. doi: 10.1016/j.radonc.2021.02.004. Online ahead of print.ABSTRACTPURPOSE: To verify clinical significance of submandibular gland (SMG)-sparing during helical tomotherapy (HT) for nasopharyngeal carcinoma (NPC) from the perspective of imaging by using diffusion weighted imaging (DWI).MATERIALS AND METHODS: In this prospective study, 60 NPC patients scheduled for radical SMG-sparing HT were enrolled. All patients underwent DWI examinations prior to HT (pre-HT) and 1, 3, 6, 9, 12 months post HT. Mean apparent diffusion coefficient (ADC) values of bilateral parotid glands (PG...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 15, 2021 Category: Radiology Authors: Wen-Jun Fan Feng Teng Gang Liu Da-Wei Zhao Jin-Feng Li Yan-Rong Luo Xin-Xin Zhang Lin Ma Jian Guan Source Type: research

Impact of a fiducial marker based ART strategy on margins in postoperative IMRT of gynecological tumors
Radiother Oncol. 2021 Feb 12:S0167-8140(21)06052-7. doi: 10.1016/j.radonc.2021.01.039. Online ahead of print.ABSTRACTPURPOSE: To investigate the potential of an offline Adaptive Radiotherapy (ART) strategy, based on the interfractional vagina motion (IVM) measured using fiducial markers (FM) during an initial number of fractions, on the CTV to PTV margins in post-operative gynecological patients.MATERIALS AND METHODS: In 18 patients, treated post-operatively for gynecological tumors, the systematic residual IVM was quantified after simulating an offline ART procedure, utilizing the average IVM measured with FM for a varyin...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 15, 2021 Category: Radiology Authors: R T T Monica Buijs Monique C W M Bloemers Peter Remeijer Source Type: research

Head and Neck Imaging Surveillance Strategy for HPV-positive Oropharyngeal Carcinoma Following Definitive (Chemo)Radiotherapy.
CONCLUSIONS: Pattern of HN imaging utilization for surveillance varied significantly among clinicians. Imaging surveillance reduces the need for ND. However, routine HN-CT/MR surveillance without clinical symptoms/signs does not demonstrate proven value in identifying locoregional failure or toxicity. Radiologic "residual" LNs without adverse features are common. If two subsequent follow-up scans demonstrate stable/regressing radiologic "residual" LNs, clinical surveillance without further imaging appears to be safe in this population. PMID: 33600871 [PubMed - as supplied by publisher] (Source: Rad...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 15, 2021 Category: Radiology Authors: Wong ET, Hui Huang S, O'Sullivan B, Persaud V, Su J, Waldron J, Goldstein DP, de Almeida J, Ringash J, Kim J, Hope A, Bratman S, Cho J, Giuliani M, Hosni A, Spreafico A, Hansen A, Tong L, Xu W, Yu E Tags: Radiother Oncol Source Type: research

Prognostic factors of Colorectal Cancer patients with Brain Metastases.
CONCLUSIONS: ECOG performance status, number of BM and number of chemotherapy lines are the most relevant factors in the management of patients with BM from CRC. PMID: 33600872 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 15, 2021 Category: Radiology Authors: Roussille P, Auvray M, Vansteene D, Lecomte T, Rigault E, Maillet M, Locher C, Dior M, Hautefeuille V, Artru P, Mabro M, Touchefeu Y, Marthey L, Moulin V, Louafi S, Lecaille C, Chautard R, Lièvre A, Zaanan A, Bennouna J, Berger A, Emambux S, Randrian V, Tags: Radiother Oncol Source Type: research

Effectiveness of fractionated carbon ion treatments in three rat prostate tumors differing in growth rate, differentiation and hypoxia.
CONCLUSION: 12C-ions reduce the radiation response heterogeneity between the three tumor sublines as well as within each subline relative to photon treatments, independently of fractionation. The dose dependence of the RBE varies between tumors of different histology. The results support the use of hypofractionated carbon ion treatments in radioresistant tumors. PMID: 33587966 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 12, 2021 Category: Radiology Authors: Glowa C, Peschke P, Brons S, Debus J, Karger CP Tags: Radiother Oncol Source Type: research

Evaluation of Interim MRI Changes During Limited-Field Radiation Therapy for Glioblastoma and Implications for Treatment Planning.
CONCLUSIONS: Initial CTV margin of 15 mm followed by a boost CTV margin of 7 mm is a reasonable approach for LFRT of GBM. Omitting routine inclusion of T2 abnormality from GTV delineation may not jeopardize disease control. PMID: 33587967 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 12, 2021 Category: Radiology Authors: Hassanzadeh C, Rudra S, Ma S, Brenneman R, Huang Y, Henke L, Abraham C, Campian J, Tsien C, Huang J Tags: Radiother Oncol Source Type: research

Individual patient data meta-analysis of prophylactic cranial irradiation in locally advanced non-small cell lung cancer.
CONCLUSION: No OS benefit by PCI was observed, but PCI prolonged the progression-free survival and BM-free survival at an increased risk of late memory impairment and fatigue. PMID: 33587968 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 12, 2021 Category: Radiology Authors: Witlox WJA, Ramaekers BLT, Lacas B, Le Pechoux C, Pignon JP, Sun A, Wang SY, Hu C, Redman M, van der Noort V, Li N, Guckenberger M, van Tinteren H, Groen HJM, Joore MA, De Ruysscher DKM Tags: Radiother Oncol Source Type: research

The primary site of head and neck squamous cell carcinoma predicts survival benefits of EGFR inhibitors: a systematic review and meta-analysis.
Abstract BACKGROUND AND PURPOSE: To assess the survival benefits associated with epidermal growth factor receptor (EGFR) inhibitors in head and neck squamous cell carcinoma (HNSCC) according to the primary site. MATERIALS AND METHODS: A systematic review and meta-analysis were conducted for randomized phase III trials comparing treatment with or without EGFR inhibitors in locoregionally advanced, recurrent, or metastatic HNSCC. The primary and secondary endpoints were overall survival (OS) and progression-free survival (PFS), respectively. Data were pooled using a random-effects model. RESULTS: Seven tri...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 12, 2021 Category: Radiology Authors: Nie D, Wang X, Sun M, Feng Z, Pei F, Liu W, Wang Z, Han F Tags: Radiother Oncol Source Type: research

Electron dose rate and oxygen depletion protect zebrafish embryos from radiation damage.
CONCLUSION: The Flash experiment at ELBE showed that the zebrafish embryo model is appropriate for studying the radiobiological response of high dose rate irradiation. The applied high pulse dose rate was confirmed as important beam parameter as well as the pivotal role of pO2 during irradiation. PMID: 33587970 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 12, 2021 Category: Radiology Authors: Pawelke J, Brand M, Hans S, Hideghéty K, Karsch L, Lessmann E, Löck S, Schürer M, Rita Szabó E, Beyreuther E Tags: Radiother Oncol Source Type: research

Predictors for Post-treatment Biopsy Outcomes after Prostate Stereotactic Body Radiotherapy.
Abstract PURPOSE: To investigate predictors associated with post-treatment biopsy outcomes after stereotactic body radiotherapy (SBRT) for localized prostate cancer. MATERIALS AND METHODS: 257 patients treated with prostate SBRT to dose levels of 32.5 Gy to ≥40 Gy in 5-6 fractions underwent a post-treatment biopsy performed approximately two years after treatment to evaluate local control status. 73 had% intermediate-risk disease (n=187) and the remaining 17% (n=43) and 10% (n=27) had low-risk and high-risk disease, respectively. RESULTS: The incidence of positive, negative, and treatment-effect post-...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 12, 2021 Category: Radiology Authors: Zelefsky MJ, Goldman DA, Hopkins M, Pinitpatcharalert A, McBride S, Gorovets D, Ehdaie B, Fine SW, Reuter VE, Tyagi N, Happersett L, Teyateeti A, Zhang Z, Kollmeier MA Tags: Radiother Oncol Source Type: research

Diffusion weighted imaging in submandibular gland sparing helical tomotherapy for nasopharyngeal carcinoma.
Abstract PURPOSE: To verify clinical significance of submandibular gland (SMG)-sparing during helical tomotherapy (HT) for nasopharyngeal carcinoma (NPC) from the perspective of imaging by using diffusion weighted imaging (DWI). MATERIALS AND METHODS: In this prospective study, 60 NPC patients scheduled for radical SMG-sparing HT were enrolled. All patients underwent DWI examinations prior to HT (pre-HT) and 1, 3, 6, 9, 12 months post HT. Mean apparent diffusion coefficient (ADC) values of bilateral parotid glands (PGs) and submandibular glands (SMGs) were measured. Differences of ADC and changes of ADC pre a...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 12, 2021 Category: Radiology Authors: Fan WJ, Teng F, Liu G, Zhao DW, Li JF, Luo YR, Zhang XX, Ma L, Guan J Tags: Radiother Oncol Source Type: research

Impact of a fiducial marker based ART strategy on margins in postoperative IMRT of gynecological tumors.
Abstract PURPOSE: To investigate the potential of an offline Adaptive Radiotherapy (ART) strategy, based on the interfractional vagina motion (IVM) measured using fiducial markers (FM) during an initial number of fractions, on the CTV to PTV margins in post-operative gynecological patients. MATERIALS AND METHODS: In 18 patients, treated post-operatively for gynecological tumors, the systematic residual IVM was quantified after simulating an offline ART procedure, utilizing the average IVM measured with FM for a varying initial numbers of fractions to find the optimal moment to adapt the treatment plan and a t...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 12, 2021 Category: Radiology Authors: Monica Buijs RTT, C W M Bloemers M, Remeijer P Tags: Radiother Oncol Source Type: research

A multidisciplinary approach for autologous breast reconstruction: A narrative (re)view for better management.
te;trai Z Abstract Breast reconstruction and oncoplastic surgery have become an important part of breast cancer care. The use of autologous breast reconstruction (ABR) has evolved significantly with advances in microsurgery, aiming to reduce donor site complications and improve cosmesis. For years, immediate-ABR was considered a contraindication if postmastectomy irradiation (PMRT) was planned. As a result of de-escalation of axillary surgery the indication of PMRT are increasing along-side with observations that PMRT in the setting of ABR is not contraindicated. Surgical techniques may result in different amount ...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 11, 2021 Category: Radiology Authors: Kaidar-Person O, Hermann N, Poortmans P, Offersen BV, Boersma LJ, de Ruysscher D, Tramm T, Kühn T, Engberg Damsgaard T, Gentilini O, Maarse W, Sklair-Levi M, Mátrai Z Tags: Radiother Oncol Source Type: research

Automatic dosimetric verification of online adapted plans on the Unity MR-Linac using 3D EPID dosimetry.
CONCLUSION: Automatic dosimetric verification of online adapted plans on the Unity MR-Linac is feasible using in vivo 3D EPID dosimetry. Almost all online adapted plans were approved automatically by the framework. This newly developed framework is a major step forward towards the clinical implementation of a permanent safety net for the entire online adaptive workflow. PMID: 33582193 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 11, 2021 Category: Radiology Authors: Olaciregui-Ruiz I, Vivas-Maiques B, van der Velden S, Nowee ME, Mijnheer B, Mans A Tags: Radiother Oncol Source Type: research

Mechanisms of radiation-induced endothelium damage: emerging models and technologies.
Abstract Radiation-induced endothelial/vascular injury is a major complicating factor in radiotherapy and a leading cause of morbidity and mortality in nuclear or radiological catastrophes. Exposure of tissue to ionizing radiation (IR) leads to the release of oxygen radicals and proteases that results in loss of endothelial barrier function and leukocyte dysfunction leading to tissue injury and organ damage. Microvascular endothelial cells are particularly sensitive to ionizing IR and radiation-induced alterations in endothelial cell function are thought to be a critical factor in organ damage through endothelial ...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 10, 2021 Category: Radiology Authors: Wijerathne H, Langston J, Yang Q, Sun S, Miyamoto C, Kilpatrick LE, Kiani MF Tags: Radiother Oncol Source Type: research

Alexithymia and professional quality of life in radiation oncology: the moderator effect of the professional profile.
CONCLUSIONS: This study demonstrates the importance of alexithymia as a factor contributing to decreased professional QoL amongst radiation oncology professionals. Alexithymic ROs are impacted to a higher extent compared to MPs and RTTs by the indirect exposure to patients suffering. It is worth addressing these observations in professional education, aiming to improve QoL for healthcare personnel. PMID: 33577864 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 9, 2021 Category: Radiology Authors: Franco P, Di Tella M, Tesio V, Gasnier A, Petit S, Spalek M, Bibault JE, Heukelom J, Dubois L, Mullaney L, Redalen KR, Chargari C, Perryck S, Bittner MI, Bertholet J, Castelli L Tags: Radiother Oncol Source Type: research

Risk and impact of radiation related lymphopenia in lung cancer: A systematic review and meta-analysis.
Abstract BACKGROUND: Despite the modern advances in treatment techniques, the survival of locally advanced lung cancer patients continues to remain poor. Circulating lymphocytes have an important role to play in local immune response to RT as well as immune checkpoint inhibitors, and radiation related lymphopenia has been associated with inferior survival in various tumors. METHODS: We undertook this systematic review and meta-analysis to evaluate the literature on risk and impact of lymphopenia in thoracic tumors. A systematic methodology search of the PubMed, Embase and Cochrane library was performed and el...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 9, 2021 Category: Radiology Authors: Upadhyay R, Venkatesulu BP, Giridhar P, Kim BK, Sharma A, Elghazawy H, Dhanireddy B, Elumalai T, Mallick S, Harkenrider M Tags: Radiother Oncol Source Type: research

A phase 1b trial of prexasertib in combination with chemoradiation in patients with locally advanced head and neck squamous cell carcinoma.
CONCLUSION: This study did not establish a safe dose of cisplatin-radiotherapy. However, it demonstrates the proof-of-principle that prexasertib could be safely combined with cetuximab-radiotherapy. These data will provide the basis to leverage the potential radio-sensitization properties of a CHK1 inhibitor in combination with radiation or other targeted agents in a variety of therapeutic settings. PMID: 33577866 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 9, 2021 Category: Radiology Authors: Yang ES, Deutsch E, Mehmet A, Fayette J, Tao Y, Nabell L, Spencer SA, Wang XA, Spoljoric EA, Zhang W, Hynes SM, Decker RL, Lin AKB, William WN Tags: Radiother Oncol Source Type: research