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Experimental assessment of inter-centre variation in stopping-power and range prediction in particle therapy
CONCLUSION: The large inter-centre variations in SPR and range prediction justify the currently clinically used margins accounting for range uncertainty, which are of the same magnitude as the inter-centre variation. This study underlines the necessity of higher standardisation in CT-number-to-SPR conversion.PMID:34329653 | DOI:10.1016/j.radonc.2021.07.019 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 30, 2021 Category: Radiology Authors: N Peters P Wohlfahrt C V Dahlgren L de Marzi M Ellerbrock F Fracchiolla J Freeh C Gom à J G óra M F Jensen T Kajdrowicz R Mackay S Molinelli I Rinaldi V Rompokos D Siewert P van der Tol X Vermeren H Nystr öm A Lomax C Richter Source Type: research

A multi-centre analysis of adjuvant contact x-ray brachytherapy (CXB) in rectal cancer patients treated with local excision - preliminary results of the CONTEM1 study
CONCLUSION: This large multi-centre cohort study using adjuvant CXB following local excision suggests excellent oncological outcomes for these patients without completion TME. This treatment approach can be considered as an alternative for selective patients compliant with long term follow up.PMID:34329654 | DOI:10.1016/j.radonc.2021.07.021 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 30, 2021 Category: Radiology Authors: A Dhadda A Sun Myint B Thamphya I Hunter M Hershman J Gerard Source Type: research

Fiducial marker motion relative to the tumor bed has a significant impact on PTV margins in partial breast irradiation
CONCLUSIONS: Fiducial motion relative to the tumor bed between planning CT and APBI treatment is non-negligible and should be included in the PTV margin calculation to prevent geographical miss. Systematic and random errors of fiducial motion were combined with other geometric uncertainties to calculate comprehensive PTV margins for different treatment techniques.PMID:34329655 | DOI:10.1016/j.radonc.2021.07.020 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 30, 2021 Category: Radiology Authors: Nienke Hoekstra Steven Habraken Annemarie Swaak-Kragten Jean-Philippe Pignol Mischa Hoogeman Source Type: research

Elective pelvic nodal irradiation with a simultaneous hypofractionated integrated prostate boost for localized high risk prostate cancer: Long term results from a prospective clinical trial
Radiother Oncol. 2021 Jul 26:S0167-8140(21)06661-5. doi: 10.1016/j.radonc.2021.07.018. Online ahead of print.ABSTRACTBACKGROUND: To report on long-term results of elective pelvic nodal irradiation (EPNI) and a simultaneous hypofractionated prostate boost for high-risk prostate cancer.MATERIALS AND METHODS: This was a prospective single-arm study. Patients with high-risk disease (cT3, PSA>20 ng/mL, or Gleason score 8-10) were eligible. Patients received 45 Gy in 25 fractions to the prostate and pelvic lymph nodes with a simultaneous intensity-modulated radiotherapy boost of 22.5 Gy to the prostate (total dose 67.5 Gy in ...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 29, 2021 Category: Radiology Authors: Rachel M Glicksman Andrew Loblaw Gerard Morton Ewa Szumacher Hans T Chung Danny Vesprini William Chu Stanley K Liu Richard Choo Andrea Deabreu Alexandre Mamedov Liying Zhang Patrick Cheung Source Type: research

Elective pelvic nodal irradiation with a simultaneous hypofractionated integrated prostate boost for localized high risk prostate cancer: Long term results from a prospective clinical trial
Radiother Oncol. 2021 Jul 26:S0167-8140(21)06661-5. doi: 10.1016/j.radonc.2021.07.018. Online ahead of print.ABSTRACTBACKGROUND: To report on long-term results of elective pelvic nodal irradiation (EPNI) and a simultaneous hypofractionated prostate boost for high-risk prostate cancer.MATERIALS AND METHODS: This was a prospective single-arm study. Patients with high-risk disease (cT3, PSA>20 ng/mL, or Gleason score 8-10) were eligible. Patients received 45 Gy in 25 fractions to the prostate and pelvic lymph nodes with a simultaneous intensity-modulated radiotherapy boost of 22.5 Gy to the prostate (total dose 67.5 Gy in ...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 29, 2021 Category: Radiology Authors: Rachel M Glicksman Andrew Loblaw Gerard Morton Ewa Szumacher Hans T Chung Danny Vesprini William Chu Stanley K Liu Richard Choo Andrea Deabreu Alexandre Mamedov Liying Zhang Patrick Cheung Source Type: research

Reduction of GTV to high-risk CTV radiation margin in head and neck squamous cell carcinoma significantly reduced acute and late radiation-related toxicity with comparable outcomes
Radiother Oncol. 2021 Jul 23:S0167-8140(21)06659-7. doi: 10.1016/j.radonc.2021.07.016. Online ahead of print.ABSTRACTBACKGROUND AND PURPOSE: We aim to retrospectively investigate whether reducing GTV to high-risk CTV margin will significantly reduce acute and late toxicity without jeopardizing outcome in head-and-neck squamous cell carcinoma (HNSCC) treated with definitive (chemo)radiation.MATERIALS AND METHODS: Between April 2015 and April 2019, 155 consecutive patients were treated with GTV to high-risk CTV margin of 10mm and subsequently another 155 patients with 6mm margin. The CTV-PTV margin was 3mm for both groups. A...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 26, 2021 Category: Radiology Authors: Abrahim Al-Mamgani Rob Kessels Arash Navran Olga Hamming-Vrieze Charlotte L Zuur Jan Paul de Boer Marcel C J Jonker Tomas Janssen Jan-Jakob Sonke Corrie A M Marijnen Source Type: research

The impact of radiotherapy protocol adherence on the outcome of patients with locally advanced NSCLC treated with concurrent chemoradiation: results from the radiotherapy quality assurance of the multicentre international randomized PET-Plan trial
Radiother Oncol. 2021 Jul 23:S0167-8140(21)06660-3. doi: 10.1016/j.radonc.2021.07.017. Online ahead of print.ABSTRACTINTRODUCTION: The success of intensification and personalisation of the curative treatment of non-small cell lung cancer (NSCLC) is strongly associated with the precision in radiotherapy. Here, we evaluate the impact of radiotherapy protocol adherence in a prospective multicentre trial.METHODS: In the open-label, randomised, controlled PET-Plan trial, patients with inoperable NSCLC were randomized at a 1:1 ratio regarding the target volume delineation informed by 1F-FDG PET and CT plus elective nodal irradia...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 26, 2021 Category: Radiology Authors: Eleni Gkika Tanja Schimek-Jasch Stephanie Kremp Stefan Lenz Marcus Stockinger Andrea Schaefer-Schuler Michael Mix Andreas K üsters Marco Tosch Thomas Hehr Susanne Martina Eschmann Yves-Pierre Bultel Peter Hass Jochen Fleckenstein Alexander Henry Thieme K Source Type: research

Reduction of GTV to high-risk CTV radiation margin in head and neck squamous cell carcinoma significantly reduced acute and late radiation-related toxicity with comparable outcomes
Radiother Oncol. 2021 Jul 23:S0167-8140(21)06659-7. doi: 10.1016/j.radonc.2021.07.016. Online ahead of print.ABSTRACTBACKGROUND AND PURPOSE: We aim to retrospectively investigate whether reducing GTV to high-risk CTV margin will significantly reduce acute and late toxicity without jeopardizing outcome in head-and-neck squamous cell carcinoma (HNSCC) treated with definitive (chemo)radiation.MATERIALS AND METHODS: Between April 2015 and April 2019, 155 consecutive patients were treated with GTV to high-risk CTV margin of 10mm and subsequently another 155 patients with 6mm margin. The CTV-PTV margin was 3mm for both groups. A...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 26, 2021 Category: Radiology Authors: Abrahim Al-Mamgani Rob Kessels Arash Navran Olga Hamming-Vrieze Charlotte L Zuur Jan Paul de Boer Marcel C J Jonker Tomas Janssen Jan-Jakob Sonke Corrie A M Marijnen Source Type: research

The impact of radiotherapy protocol adherence on the outcome of patients with locally advanced NSCLC treated with concurrent chemoradiation: results from the radiotherapy quality assurance of the multicentre international randomized PET-Plan trial
Radiother Oncol. 2021 Jul 23:S0167-8140(21)06660-3. doi: 10.1016/j.radonc.2021.07.017. Online ahead of print.ABSTRACTINTRODUCTION: The success of intensification and personalisation of the curative treatment of non-small cell lung cancer (NSCLC) is strongly associated with the precision in radiotherapy. Here, we evaluate the impact of radiotherapy protocol adherence in a prospective multicentre trial.METHODS: In the open-label, randomised, controlled PET-Plan trial, patients with inoperable NSCLC were randomized at a 1:1 ratio regarding the target volume delineation informed by 1F-FDG PET and CT plus elective nodal irradia...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 26, 2021 Category: Radiology Authors: Eleni Gkika Tanja Schimek-Jasch Stephanie Kremp Stefan Lenz Marcus Stockinger Andrea Schaefer-Schuler Michael Mix Andreas K üsters Marco Tosch Thomas Hehr Susanne Martina Eschmann Yves-Pierre Bultel Peter Hass Jochen Fleckenstein Alexander Henry Thieme K Source Type: research

Reduction of GTV to high-risk CTV radiation margin in head and neck squamous cell carcinoma significantly reduced acute and late radiation-related toxicity with comparable outcomes
Radiother Oncol. 2021 Jul 23:S0167-8140(21)06659-7. doi: 10.1016/j.radonc.2021.07.016. Online ahead of print.ABSTRACTBACKGROUND AND PURPOSE: We aim to retrospectively investigate whether reducing GTV to high-risk CTV margin will significantly reduce acute and late toxicity without jeopardizing outcome in head-and-neck squamous cell carcinoma (HNSCC) treated with definitive (chemo)radiation.MATERIALS AND METHODS: Between April 2015 and April 2019, 155 consecutive patients were treated with GTV to high-risk CTV margin of 10mm and subsequently another 155 patients with 6mm margin. The CTV-PTV margin was 3mm for both groups. A...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 26, 2021 Category: Radiology Authors: Abrahim Al-Mamgani Rob Kessels Arash Navran Olga Hamming-Vrieze Charlotte L Zuur Jan Paul de Boer Marcel C J Jonker Tomas Janssen Jan-Jakob Sonke Corrie A M Marijnen Source Type: research

The impact of radiotherapy protocol adherence on the outcome of patients with locally advanced NSCLC treated with concurrent chemoradiation: results from the radiotherapy quality assurance of the multicentre international randomized PET-Plan trial
Radiother Oncol. 2021 Jul 23:S0167-8140(21)06660-3. doi: 10.1016/j.radonc.2021.07.017. Online ahead of print.ABSTRACTINTRODUCTION: The success of intensification and personalisation of the curative treatment of non-small cell lung cancer (NSCLC) is strongly associated with the precision in radiotherapy. Here, we evaluate the impact of radiotherapy protocol adherence in a prospective multicentre trial.METHODS: In the open-label, randomised, controlled PET-Plan trial, patients with inoperable NSCLC were randomized at a 1:1 ratio regarding the target volume delineation informed by 1F-FDG PET and CT plus elective nodal irradia...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 26, 2021 Category: Radiology Authors: Eleni Gkika Tanja Schimek-Jasch Stephanie Kremp Stefan Lenz Marcus Stockinger Andrea Schaefer-Schuler Michael Mix Andreas K üsters Marco Tosch Thomas Hehr Susanne Martina Eschmann Yves-Pierre Bultel Peter Hass Jochen Fleckenstein Alexander Henry Thieme K Source Type: research

Tricks and tips for target volume definition and delineation in breast cancer: lessons learned from ESTRO breast courses
Radiother Oncol. 2021 Jul 21:S0167-8140(21)06658-5. doi: 10.1016/j.radonc.2021.07.015. Online ahead of print.ABSTRACTDelineation of target and 'organ at risk (OAR)' volumes is a critical part of modern radiation therapy planning, the next essential step after deciding the indication, patient discussion and image acquisition. Adoption of volume-based treatment planning for non-metastatic breast cancer has increased greatly along with the use of improved planning techniques, essential for modern therapy. However, identifying the volumes on a planning CT is no easy task. The current paper is written by ESTRO's breast course f...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 24, 2021 Category: Radiology Authors: O Kaidar-Person B V Offersen L Boersma I Meattini D Dodwell L Wyld M Aznar T Major T Kuehn V Strand M Palmu S Hol P Poortmans Source Type: research

Tricks and tips for target volume definition and delineation in breast cancer: lessons learned from ESTRO breast courses
Radiother Oncol. 2021 Jul 21:S0167-8140(21)06658-5. doi: 10.1016/j.radonc.2021.07.015. Online ahead of print.ABSTRACTDelineation of target and 'organ at risk (OAR)' volumes is a critical part of modern radiation therapy planning, the next essential step after deciding the indication, patient discussion and image acquisition. Adoption of volume-based treatment planning for non-metastatic breast cancer has increased greatly along with the use of improved planning techniques, essential for modern therapy. However, identifying the volumes on a planning CT is no easy task. The current paper is written by ESTRO's breast course f...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 24, 2021 Category: Radiology Authors: O Kaidar-Person B V Offersen L Boersma I Meattini D Dodwell L Wyld M Aznar T Major T Kuehn V Strand M Palmu S Hol P Poortmans Source Type: research

Tricks and tips for target volume definition and delineation in breast cancer: lessons learned from ESTRO breast courses
Radiother Oncol. 2021 Jul 21:S0167-8140(21)06658-5. doi: 10.1016/j.radonc.2021.07.015. Online ahead of print.ABSTRACTDelineation of target and 'organ at risk (OAR)' volumes is a critical part of modern radiation therapy planning, the next essential step after deciding the indication, patient discussion and image acquisition. Adoption of volume-based treatment planning for non-metastatic breast cancer has increased greatly along with the use of improved planning techniques, essential for modern therapy. However, identifying the volumes on a planning CT is no easy task. The current paper is written by ESTRO's breast course f...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 24, 2021 Category: Radiology Authors: O Kaidar-Person B V Offersen L Boersma I Meattini D Dodwell L Wyld M Aznar T Major T Kuehn V Strand M Palmu S Hol P Poortmans Source Type: research

Seminal vesicle intrafraction motion during the delivery of radiotherapy sessions on a 1.5 T MR-Linac
ConclusionThis is the first study to investigate SV intrafraction motion during MR-guided RT sessions on an MR-Linac. We have shown that high quality 3D cine-MR imaging and SV tracking during RT is feasible with beam-on. The tracking method as described may be used as input for a fast replanning algorithm, which allows for intrafraction plan adaptation.PMID:34293410 | DOI:10.1016/j.radonc.2021.07.014 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 22, 2021 Category: Radiology Authors: D M Muinck Keizer T Willigenburg J R N der Voort van Zyp B W Raaymakers J J W Lagendijk J C J Boer Source Type: research

Seminal vesicle intrafraction motion during the delivery of radiotherapy sessions on a 1.5 T MR-Linac
ConclusionThis is the first study to investigate SV intrafraction motion during MR-guided RT sessions on an MR-Linac. We have shown that high quality 3D cine-MR imaging and SV tracking during RT is feasible with beam-on. The tracking method as described may be used as input for a fast replanning algorithm, which allows for intrafraction plan adaptation.PMID:34293410 | DOI:10.1016/j.radonc.2021.07.014 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 22, 2021 Category: Radiology Authors: D M Muinck Keizer T Willigenburg J R N der Voort van Zyp B W Raaymakers J J W Lagendijk J C J Boer Source Type: research

Outcomes of and Treatment Planning Considerations for A Hybrid Technique Delivering Proton Pencil-Beam Scanning Radiation to Women with Metal-Containing Tissue Expanders Undergoing Post-Mastectomy Radiation
CONCLUSIONS: Delivering PMRT with PBS for women with metal-containing TEs using a hybrid SFO/MFO technique is feasible, reproducible, and achieves excellent dose distributions. Additional techniques are required to safely utilize this treatment in the clinic.PMID:34280402 | DOI:10.1016/j.radonc.2021.07.012 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 19, 2021 Category: Radiology Authors: Cristina M DeCesaris Sina Mossahebi Jenna Jatczak Avani D Rao Mingyao Zhu Mark V Mishra Elizabeth Nichols Source Type: research

Chemical Exchange Saturation Transfer MRI in Central Nervous System Tumours on a 1.5T MR-Linac
CONCLUSION: CEST MRI using a 1.5T MR-Linac was demonstrated to be feasible for in vivo imaging of CNS tumours. CEST images showed tumour/white-matter contrast, temporal CEST signal changes, and associations with tumour grade. These results show promise for the eventual goal of using metabolic imaging to inform the design of adaptive radiotherapy protocols.PMID:34280403 | DOI:10.1016/j.radonc.2021.07.010 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 19, 2021 Category: Radiology Authors: Rachel W Chan Liam S P Lawrence Ryan T Oglesby Hanbo Chen James Stewart Aimee Theriault Mikki Campbell Mark Ruschin Sten Myrehaug Eshetu G Atenafu Brian Keller Brige Chugh Scott MacKenzie Chia-Lin Tseng Jay Detsky Pejman J Maralani Greg J Czarnota Greg J Source Type: research

Planning Target Volume margin assessment for online adaptive MR-guided dose-escalation in rectal cancer on a 1.5T MR-Linac
CONCLUSION: The shorter the treatment time, the smaller the margins needed to cover for the GTV movement during an online adaptive MRgRT dose-escalation strategy for intermediate risk rectal cancer. When time intervals between replanning and the end of dose delivery could be reduced to 15 minutes, a 4 mm margin would allow adequate target coverage.PMID:34280404 | DOI:10.1016/j.radonc.2021.07.011 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 19, 2021 Category: Radiology Authors: Hidde Eijkelenkamp Mick R Boekhoff Maaike E Verweij Femke P Peters Gert J Meijer Martijn P W Intven Source Type: research

Outcomes of and Treatment Planning Considerations for A Hybrid Technique Delivering Proton Pencil-Beam Scanning Radiation to Women with Metal-Containing Tissue Expanders Undergoing Post-Mastectomy Radiation
CONCLUSIONS: Delivering PMRT with PBS for women with metal-containing TEs using a hybrid SFO/MFO technique is feasible, reproducible, and achieves excellent dose distributions. Additional techniques are required to safely utilize this treatment in the clinic.PMID:34280402 | DOI:10.1016/j.radonc.2021.07.012 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 19, 2021 Category: Radiology Authors: Cristina M DeCesaris Sina Mossahebi Jenna Jatczak Avani D Rao Mingyao Zhu Mark V Mishra Elizabeth Nichols Source Type: research

Chemical Exchange Saturation Transfer MRI in Central Nervous System Tumours on a 1.5T MR-Linac
CONCLUSION: CEST MRI using a 1.5T MR-Linac was demonstrated to be feasible for in vivo imaging of CNS tumours. CEST images showed tumour/white-matter contrast, temporal CEST signal changes, and associations with tumour grade. These results show promise for the eventual goal of using metabolic imaging to inform the design of adaptive radiotherapy protocols.PMID:34280403 | DOI:10.1016/j.radonc.2021.07.010 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 19, 2021 Category: Radiology Authors: Rachel W Chan Liam S P Lawrence Ryan T Oglesby Hanbo Chen James Stewart Aimee Theriault Mikki Campbell Mark Ruschin Sten Myrehaug Eshetu G Atenafu Brian Keller Brige Chugh Scott MacKenzie Chia-Lin Tseng Jay Detsky Pejman J Maralani Greg J Czarnota Greg J Source Type: research

Planning Target Volume margin assessment for online adaptive MR-guided dose-escalation in rectal cancer on a 1.5T MR-Linac
CONCLUSION: The shorter the treatment time, the smaller the margins needed to cover for the GTV movement during an online adaptive MRgRT dose-escalation strategy for intermediate risk rectal cancer. When time intervals between replanning and the end of dose delivery could be reduced to 15 minutes, a 4 mm margin would allow adequate target coverage.PMID:34280404 | DOI:10.1016/j.radonc.2021.07.011 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 19, 2021 Category: Radiology Authors: Hidde Eijkelenkamp Mick R Boekhoff Maaike E Verweij Femke P Peters Gert J Meijer Martijn P W Intven Source Type: research

Outcomes of and Treatment Planning Considerations for A Hybrid Technique Delivering Proton Pencil-Beam Scanning Radiation to Women with Metal-Containing Tissue Expanders Undergoing Post-Mastectomy Radiation
CONCLUSIONS: Delivering PMRT with PBS for women with metal-containing TEs using a hybrid SFO/MFO technique is feasible, reproducible, and achieves excellent dose distributions. Additional techniques are required to safely utilize this treatment in the clinic.PMID:34280402 | DOI:10.1016/j.radonc.2021.07.012 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 19, 2021 Category: Radiology Authors: Cristina M DeCesaris Sina Mossahebi Jenna Jatczak Avani D Rao Mingyao Zhu Mark V Mishra Elizabeth Nichols Source Type: research

Chemical Exchange Saturation Transfer MRI in Central Nervous System Tumours on a 1.5T MR-Linac
CONCLUSION: CEST MRI using a 1.5T MR-Linac was demonstrated to be feasible for in vivo imaging of CNS tumours. CEST images showed tumour/white-matter contrast, temporal CEST signal changes, and associations with tumour grade. These results show promise for the eventual goal of using metabolic imaging to inform the design of adaptive radiotherapy protocols.PMID:34280403 | DOI:10.1016/j.radonc.2021.07.010 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 19, 2021 Category: Radiology Authors: Rachel W Chan Liam S P Lawrence Ryan T Oglesby Hanbo Chen James Stewart Aimee Theriault Mikki Campbell Mark Ruschin Sten Myrehaug Eshetu G Atenafu Brian Keller Brige Chugh Scott MacKenzie Chia-Lin Tseng Jay Detsky Pejman J Maralani Greg J Czarnota Greg J Source Type: research

Planning Target Volume margin assessment for online adaptive MR-guided dose-escalation in rectal cancer on a 1.5T MR-Linac
CONCLUSION: The shorter the treatment time, the smaller the margins needed to cover for the GTV movement during an online adaptive MRgRT dose-escalation strategy for intermediate risk rectal cancer. When time intervals between replanning and the end of dose delivery could be reduced to 15 minutes, a 4 mm margin would allow adequate target coverage.PMID:34280404 | DOI:10.1016/j.radonc.2021.07.011 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 19, 2021 Category: Radiology Authors: Hidde Eijkelenkamp Mick R Boekhoff Maaike E Verweij Femke P Peters Gert J Meijer Martijn P W Intven Source Type: research

Stereotactic body radiation therapy with sequential S-1 for patients with locally advanced pancreatic cancer and poor performance status: an open-label, single-arm, phase 2 trial
CONCLUSIONS: SBRT with sequential S-1 shows promising efficacy and acceptable toxicity in poor performance status patients with LAPC.PMID:34274393 | DOI:10.1016/j.radonc.2021.07.009 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 18, 2021 Category: Radiology Authors: Xiaofei Zhu Yangsen Cao Mingzhi Lu Xianzhi Zhao Lingong Jiang Yusheng Ye Xiaoping Ju Huojun Zhang Source Type: research

Comment on "Photobiomodulation therapy for the prevention of acute radiation dermatitis (RD) in head and neck cancer patients (DERMISHEAD trial)"
Radiother Oncol. 2021 Jul 15:S0167-8140(21)06642-1. doi: 10.1016/j.radonc.2021.07.005. Online ahead of print.NO ABSTRACTPMID:34274394 | DOI:10.1016/j.radonc.2021.07.005 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 18, 2021 Category: Radiology Authors: Jaqueline Munaretto Timm Baiocchi Francine Fischer-Sgrott Glauco Baiocchi Neto Source Type: research

Response to the Comment on "Photobiomodulation therapy for the prevention of acute radiation dermatitis (RD) in head and neck cancer patients (DERMISHEAD trial)" by Baiocchi et al
Radiother Oncol. 2021 Jul 15:S0167-8140(21)06639-1. doi: 10.1016/j.radonc.2021.07.002. Online ahead of print.NO ABSTRACTPMID:34274395 | DOI:10.1016/j.radonc.2021.07.002 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 18, 2021 Category: Radiology Authors: Jolien Robijns Joy Lodewijckx Stefan Claes Leen Van Bever Luc Pannekoeke Sandrine Censabella Lore Buss é Dora Colson Iris Kaminski Victoria Broux Sofie Puts Sofie Vanmechelen An Timmermans Leen No é Paul Bulens Mieke Govers Annelies Maes Jeroen Mebis Source Type: research

Stereotactic body radiation therapy with sequential S-1 for patients with locally advanced pancreatic cancer and poor performance status: an open-label, single-arm, phase 2 trial
CONCLUSIONS: SBRT with sequential S-1 shows promising efficacy and acceptable toxicity in poor performance status patients with LAPC.PMID:34274393 | DOI:10.1016/j.radonc.2021.07.009 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 18, 2021 Category: Radiology Authors: Xiaofei Zhu Yangsen Cao Mingzhi Lu Xianzhi Zhao Lingong Jiang Yusheng Ye Xiaoping Ju Huojun Zhang Source Type: research

Comment on "Photobiomodulation therapy for the prevention of acute radiation dermatitis (RD) in head and neck cancer patients (DERMISHEAD trial)"
Radiother Oncol. 2021 Jul 15:S0167-8140(21)06642-1. doi: 10.1016/j.radonc.2021.07.005. Online ahead of print.NO ABSTRACTPMID:34274394 | DOI:10.1016/j.radonc.2021.07.005 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 18, 2021 Category: Radiology Authors: Jaqueline Munaretto Timm Baiocchi Francine Fischer-Sgrott Glauco Baiocchi Neto Source Type: research

Response to the Comment on "Photobiomodulation therapy for the prevention of acute radiation dermatitis (RD) in head and neck cancer patients (DERMISHEAD trial)" by Baiocchi et al
Radiother Oncol. 2021 Jul 15:S0167-8140(21)06639-1. doi: 10.1016/j.radonc.2021.07.002. Online ahead of print.NO ABSTRACTPMID:34274395 | DOI:10.1016/j.radonc.2021.07.002 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 18, 2021 Category: Radiology Authors: Jolien Robijns Joy Lodewijckx Stefan Claes Leen Van Bever Luc Pannekoeke Sandrine Censabella Lore Buss é Dora Colson Iris Kaminski Victoria Broux Sofie Puts Sofie Vanmechelen An Timmermans Leen No é Paul Bulens Mieke Govers Annelies Maes Jeroen Mebis Source Type: research

Extreme weekly locoregional hypofractionated radiation in elderly women with non-metastatic breast cancer
Radiother Oncol. 2021 Jul 14:S0167-8140(21)06645-7. doi: 10.1016/j.radonc.2021.07.008. Online ahead of print.NO ABSTRACTPMID:34273468 | DOI:10.1016/j.radonc.2021.07.008 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 17, 2021 Category: Radiology Authors: Fadoua Rais James Man Git Tsui Allyssa Daianska Mame Daro Faye Christine Lambert Marc David Valerie Panet-Raymond Melissa Azoulay Asma Saidi Tarek Hijal Source Type: research

Extreme weekly locoregional hypofractionated radiation in elderly women with non-metastatic breast cancer
Radiother Oncol. 2021 Jul 14:S0167-8140(21)06645-7. doi: 10.1016/j.radonc.2021.07.008. Online ahead of print.NO ABSTRACTPMID:34273468 | DOI:10.1016/j.radonc.2021.07.008 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 17, 2021 Category: Radiology Authors: Fadoua Rais James Man Git Tsui Allyssa Daianska Mame Daro Faye Christine Lambert Marc David Valerie Panet-Raymond Melissa Azoulay Asma Saidi Tarek Hijal Source Type: research

Definitive chemoradiotherapy versus esophagectomy in patients with clinical T1bN0M0 esophageal squamous cell carcinoma: a retrospective study
This study aimed to determine the equivalence between definitive chemoradiotherapy (DCRT) and radical esophagectomy in clinical T1bN0M0 esophageal squamous cell carcinoma (ESCC).MATERIALS AND METHODS: Among 282 patients with cT1bN0M0 ESCC, 238 underwent radical esophagectomy and 44 underwent DCRT. Both treatments were retrospectively compared overall survival (OS), progression-free survival (PFS), and complications.RESULTS: The DCRT group exhibited poorer patient characteristics than the surgery group, especially with mean age (73 vs. 63 years), Eastern Cooperative Oncology Group (ECOG) status, and Charlson Comorbidity Index (p
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 15, 2021 Category: Radiology Authors: Yoon Young Jo Jesang Yu Kye Jin Song Jeong Yun Jang Ye Jin Yoo Sung-Bae Kim Sook Ryun Park Yong-Hee Kim Hyeong Ryul Kim Jong Hoon Kim Source Type: research

A radiomic signature model to predict the chemoradiation-induced alteration in tumor-infiltrating CD8 < sup > + < /sup > cells in locally advanced rectal cancer
CONCLUSION: We established the MRI-derived radiomic signature for predicting CRT-induced alterations in CD8+ TILs. This study suggests the clinical utility of radiomics-immunophenotype modeling to evaluate tumor immune status following neoadjuvant chemoradiation in rectal cancer.PMID:34265357 | DOI:10.1016/j.radonc.2021.07.004 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 15, 2021 Category: Radiology Authors: Seung Hyuck Jeon Yu Jin Lim Jaemoon Koh Won Ick Chang Sehui Kim Kyubo Kim Eui Kyu Chie Source Type: research

Definitive chemoradiotherapy versus esophagectomy in patients with clinical T1bN0M0 esophageal squamous cell carcinoma: a retrospective study
This study aimed to determine the equivalence between definitive chemoradiotherapy (DCRT) and radical esophagectomy in clinical T1bN0M0 esophageal squamous cell carcinoma (ESCC).MATERIALS AND METHODS: Among 282 patients with cT1bN0M0 ESCC, 238 underwent radical esophagectomy and 44 underwent DCRT. Both treatments were retrospectively compared overall survival (OS), progression-free survival (PFS), and complications.RESULTS: The DCRT group exhibited poorer patient characteristics than the surgery group, especially with mean age (73 vs. 63 years), Eastern Cooperative Oncology Group (ECOG) status, and Charlson Comorbidity Index (p
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 15, 2021 Category: Radiology Authors: Yoon Young Jo Jesang Yu Kye Jin Song Jeong Yun Jang Ye Jin Yoo Sung-Bae Kim Sook Ryun Park Yong-Hee Kim Hyeong Ryul Kim Jong Hoon Kim Source Type: research

A radiomic signature model to predict the chemoradiation-induced alteration in tumor-infiltrating CD8 < sup > + < /sup > cells in locally advanced rectal cancer
CONCLUSION: We established the MRI-derived radiomic signature for predicting CRT-induced alterations in CD8+ TILs. This study suggests the clinical utility of radiomics-immunophenotype modeling to evaluate tumor immune status following neoadjuvant chemoradiation in rectal cancer.PMID:34265357 | DOI:10.1016/j.radonc.2021.07.004 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 15, 2021 Category: Radiology Authors: Seung Hyuck Jeon Yu Jin Lim Jaemoon Koh Won Ick Chang Sehui Kim Kyubo Kim Eui Kyu Chie Source Type: research

"It's good for the soul:" perceptions of a formal junior faculty mentorship program at a large academic cancer centre
CONCLUSION: Implementation of a junior faculty mentorship program within an academic radiation oncology department is feasible. Participants expressed satisfaction with most formal program components. Many junior faculty have additional mentors; however, some do not, highlighting the importance of formal programs for professional development.PMID:34256081 | DOI:10.1016/j.radonc.2021.07.003 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 13, 2021 Category: Radiology Authors: Jennifer Croke Sarah Tosoni Jolie Ringash Source Type: research

"It's good for the soul:" perceptions of a formal junior faculty mentorship program at a large academic cancer centre
CONCLUSION: Implementation of a junior faculty mentorship program within an academic radiation oncology department is feasible. Participants expressed satisfaction with most formal program components. Many junior faculty have additional mentors; however, some do not, highlighting the importance of formal programs for professional development.PMID:34256081 | DOI:10.1016/j.radonc.2021.07.003 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 13, 2021 Category: Radiology Authors: Jennifer Croke Sarah Tosoni Jolie Ringash Source Type: research

"It's good for the soul:" perceptions of a formal junior faculty mentorship program at a large academic cancer centre
CONCLUSION: Implementation of a junior faculty mentorship program within an academic radiation oncology department is feasible. Participants expressed satisfaction with most formal program components. Many junior faculty have additional mentors; however, some do not, highlighting the importance of formal programs for professional development.PMID:34256081 | DOI:10.1016/j.radonc.2021.07.003 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 13, 2021 Category: Radiology Authors: Jennifer Croke Sarah Tosoni Jolie Ringash Source Type: research

Margin calculation for multiple lung metastases treated with single-isocenter SBRT
CONCLUSION: Relative inter-lesion position variation is influenced by inter-target distance and location and can be compensated with additional safety margins of
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 12, 2021 Category: Radiology Authors: Janita E van Timmeren Mischa S Hoogeman Stefanie Ehrbar Michael Mayinger Nicolaus Andratschke Matthias Guckenberger Stephanie Tanadini-Lang Source Type: research

Corrigendum to "Local control and postponement of systemic therapy after modest dose radiotherapy in oligometastatic myxoid liposarcomas" [Radiother. Oncol. 158 (2021) 33-39]
Radiother Oncol. 2021 Jul 6:S0167-8140(21)06256-3. doi: 10.1016/j.radonc.2021.05.018. Online ahead of print.NO ABSTRACTPMID:34243980 | DOI:10.1016/j.radonc.2021.05.018 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 10, 2021 Category: Radiology Authors: Jules Lansu Winan J van Houdt Kirsten van Langevelde Piet L A van den Ende Winette T A van der Graaf Yvonne Schrage Hester van Boven Astrid N Scholten Rick L Haas Source Type: research

Corrigendum to "Local control and postponement of systemic therapy after modest dose radiotherapy in oligometastatic myxoid liposarcomas" [Radiother. Oncol. 158 (2021) 33-39]
Radiother Oncol. 2021 Jul 6:S0167-8140(21)06256-3. doi: 10.1016/j.radonc.2021.05.018. Online ahead of print.NO ABSTRACTPMID:34243980 | DOI:10.1016/j.radonc.2021.05.018 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 10, 2021 Category: Radiology Authors: Jules Lansu Winan J van Houdt Kirsten van Langevelde Piet L A van den Ende Winette T A van der Graaf Yvonne Schrage Hester van Boven Astrid N Scholten Rick L Haas Source Type: research

Corrigendum to "Local control and postponement of systemic therapy after modest dose radiotherapy in oligometastatic myxoid liposarcomas" [Radiother. Oncol. 158 (2021) 33-39]
Radiother Oncol. 2021 Jul 6:S0167-8140(21)06256-3. doi: 10.1016/j.radonc.2021.05.018. Online ahead of print.NO ABSTRACTPMID:34243980 | DOI:10.1016/j.radonc.2021.05.018 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 10, 2021 Category: Radiology Authors: Jules Lansu Winan J van Houdt Kirsten van Langevelde Piet L A van den Ende Winette T A van der Graaf Yvonne Schrage Hester van Boven Astrid N Scholten Rick L Haas Source Type: research

High-dose irradiation in combination with non-ablative low-dose radiation to treat metastatic disease after progression on immunotherapy: results of a phase II trial
Radiother Oncol. 2021 Jul 5:S0167-8140(21)06625-1. doi: 10.1016/j.radonc.2021.06.037. Online ahead of print.ABSTRACTAIM: To report early findings from a phase II trial of high-dose radiotherapy (HD-RT) with or without low-dose RT (LD-RT) for metastatic cancer.METHODS: Eligible patients had metastatic disease that progressed on immunotherapy within 6 months. Patients were given either HD-RT (20-70 Gy total; 3-12.5 Gy/f), or HD-RT+LD-RT (0.5-2 Gy/f up to 1-10 Gy total) to separate lesions, with continued immunotherapy. Radiographic response was assessed per RECIST 1.1 and Immune-Related Response Criteria (irRC). Primary endp...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 8, 2021 Category: Radiology Authors: Roshal R Patel Kewen He Hampartsoum B Barsoumian Joe Y Chang Chad Tang Vivek Verma Nathan Comeaux Stephen G Chun Saumil Gandhi Mylene T Truong Jeremy J Erasmus David S Hong Percy P Lee Matthew S Ning Quynh-Nhu Nguyen John V Heymach Mehmet Altan George Blu Source Type: research

Quality of life and toxicity guided treatment plan optimisation for head and neck cancer
This study included 30 HNC patients who were treated with definitive radiotherapy. QOL-weighted NTCP-guided VMAT plans were optimised directly on 80 multivariable NTCP models of 20 common toxicities and symptoms on 4 different time points (6, 12, 18 and 24 months after radiotherapy) and each NTCP model was weighted relative to its impact on QOL. Planning results, NTCP and predicted QOL were compared with the clinical conventional VMAT plans.RESULTS: QOL-weighted NTCP-guided VMAT plans were clinically acceptable, had target coverage equally adequate as the clinical plans, but prioritised sparing of organs at risk (OAR) rela...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 8, 2021 Category: Radiology Authors: Hans Paul van der Laan Arjen van der Schaaf Lisa Van den Bosch Erik W Korevaar Roel J H M Steenbakkers Stefan Both Johannes A Langendijk Source Type: research

An in-silico assessment of the dosimetric benefits of MR-guided radiotherapy for esophageal cancer patients
CONCLUSION: This study revealed that MRgRT for esophageal cancer has the potential to significantly reduce the dose to heart and lungs. In addition, online high precision targeting of the primary tumor opens new perspectives for local boosting strategies to improve outcome of the local management of this disease.PMID:34237345 | DOI:10.1016/j.radonc.2021.06.038 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 8, 2021 Category: Radiology Authors: M R Boekhoff I L Defize A S Borggreve R van Hillegersberg A N T J Kotte J J W Lagendijk A L H M W van Lier J P Ruurda N Takahashi S Mook G J Meijer Source Type: research

High-dose irradiation in combination with non-ablative low-dose radiation to treat metastatic disease after progression on immunotherapy: results of a phase II trial
Radiother Oncol. 2021 Jul 5:S0167-8140(21)06625-1. doi: 10.1016/j.radonc.2021.06.037. Online ahead of print.ABSTRACTAIM: To report early findings from a phase II trial of high-dose radiotherapy (HD-RT) with or without low-dose RT (LD-RT) for metastatic cancer.METHODS: Eligible patients had metastatic disease that progressed on immunotherapy within 6 months. Patients were given either HD-RT (20-70 Gy total; 3-12.5 Gy/f), or HD-RT+LD-RT (0.5-2 Gy/f up to 1-10 Gy total) to separate lesions, with continued immunotherapy. Radiographic response was assessed per RECIST 1.1 and Immune-Related Response Criteria (irRC). Primary endp...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 8, 2021 Category: Radiology Authors: Roshal R Patel Kewen He Hampartsoum B Barsoumian Joe Y Chang Chad Tang Vivek Verma Nathan Comeaux Stephen G Chun Saumil Gandhi Mylene T Truong Jeremy J Erasmus David S Hong Percy P Lee Matthew S Ning Quynh-Nhu Nguyen John V Heymach Mehmet Altan George Blu Source Type: research

Quality of life and toxicity guided treatment plan optimisation for head and neck cancer
This study included 30 HNC patients who were treated with definitive radiotherapy. QOL-weighted NTCP-guided VMAT plans were optimised directly on 80 multivariable NTCP models of 20 common toxicities and symptoms on 4 different time points (6, 12, 18 and 24 months after radiotherapy) and each NTCP model was weighted relative to its impact on QOL. Planning results, NTCP and predicted QOL were compared with the clinical conventional VMAT plans.RESULTS: QOL-weighted NTCP-guided VMAT plans were clinically acceptable, had target coverage equally adequate as the clinical plans, but prioritised sparing of organs at risk (OAR) rela...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 8, 2021 Category: Radiology Authors: Hans Paul van der Laan Arjen van der Schaaf Lisa Van den Bosch Erik W Korevaar Roel J H M Steenbakkers Stefan Both Johannes A Langendijk Source Type: research

An in-silico assessment of the dosimetric benefits of MR-guided radiotherapy for esophageal cancer patients
CONCLUSION: This study revealed that MRgRT for esophageal cancer has the potential to significantly reduce the dose to heart and lungs. In addition, online high precision targeting of the primary tumor opens new perspectives for local boosting strategies to improve outcome of the local management of this disease.PMID:34237345 | DOI:10.1016/j.radonc.2021.06.038 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 8, 2021 Category: Radiology Authors: M R Boekhoff I L Defize A S Borggreve R van Hillegersberg A N T J Kotte J J W Lagendijk A L H M W van Lier J P Ruurda N Takahashi S Mook G J Meijer Source Type: research