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LITE SABR M1: a Phase I Trial of Lattice Stereotactic Body Radiotherapy for Large Tumors
CONCLUSIONS: This phase I study met its primary endpoint of physician reported short-term safety. An ongoing phase II clinical trial of Lattice SBRT will evaluate late safety and efficacy of this novel technique.PMID:34875286 | DOI:10.1016/j.radonc.2021.11.023 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 7, 2021 Category: Radiology Authors: Sai Duriseti James Kavanaugh Jeff Szymanski Yi Huang Franco Basarabescu Aadel Chaudhuri Lauren Henke Pamela Samson Alexander Lin Clifford Robinson Matthew B Spraker Source Type: research

Single-isocenter versus multiple-isocenters for multiple lung metastases: evaluation of lung dose
CONCLUSION: A single-isocenter SBRT technique for lung patients with multiple targets results in clinically acceptable increases in normal lung dose.PMID:34864135 | DOI:10.1016/j.radonc.2021.11.030 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 5, 2021 Category: Radiology Authors: Janita E van Timmeren Stefanie Ehrbar Madalyne Chamberlain Michael Mayinger Mischa S Hoogeman Nicolaus Andratschke Matthias Guckenberger Stephanie Tanadini-Lang Source Type: research

Late cardiac toxicity of neo-adjuvant chemoradiation in esophageal cancer survivors: a prospective cross-sectional pilot study
Radiother Oncol. 2021 Dec 2:S0167-8140(21)09025-3. doi: 10.1016/j.radonc.2021.11.029. Online ahead of print.ABSTRACTPURPOSE: Although cure rates in esophageal cancer (EC) have improved since the introduction of neoadjuvant chemoradiation (nCRT), evidence for treatment-related cardiac toxicity is growing, of which the exact mechanisms remain unknown. The primary objective of this study was to identify (subclinical) cardiac dysfunction in EC patients after nCRT followed by surgical resection as compared to surgery alone.MATERIALS AND METHODS: EC survivors followed for 5-15 years after curative resection with (n = 20) or with...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 5, 2021 Category: Radiology Authors: Jannet C Beukema Crystal de Groot John T M Plukker Rozemarijn Vliegenthart Johannes A Langendijk Peter van Luijk Joost P van Melle Niek H J Prakken Christina T Muijs Source Type: research

Single-isocenter versus multiple-isocenters for multiple lung metastases: evaluation of lung dose
CONCLUSION: A single-isocenter SBRT technique for lung patients with multiple targets results in clinically acceptable increases in normal lung dose.PMID:34864135 | DOI:10.1016/j.radonc.2021.11.030 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 5, 2021 Category: Radiology Authors: Janita E van Timmeren Stefanie Ehrbar Madalyne Chamberlain Michael Mayinger Mischa S Hoogeman Nicolaus Andratschke Matthias Guckenberger Stephanie Tanadini-Lang Source Type: research

Late cardiac toxicity of neo-adjuvant chemoradiation in esophageal cancer survivors: a prospective cross-sectional pilot study
Radiother Oncol. 2021 Dec 2:S0167-8140(21)09025-3. doi: 10.1016/j.radonc.2021.11.029. Online ahead of print.ABSTRACTPURPOSE: Although cure rates in esophageal cancer (EC) have improved since the introduction of neoadjuvant chemoradiation (nCRT), evidence for treatment-related cardiac toxicity is growing, of which the exact mechanisms remain unknown. The primary objective of this study was to identify (subclinical) cardiac dysfunction in EC patients after nCRT followed by surgical resection as compared to surgery alone.MATERIALS AND METHODS: EC survivors followed for 5-15 years after curative resection with (n = 20) or with...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 5, 2021 Category: Radiology Authors: Jannet C Beukema Crystal de Groot John T M Plukker Rozemarijn Vliegenthart Johannes A Langendijk Peter van Luijk Joost P van Melle Niek H J Prakken Christina T Muijs Source Type: research

Performance of an integrated multimodality image guidance and dose-planning system supporting tumor-targeted HDR brachytherapy for prostate cancer
CONCLUSION: The system supported tumor-targeting and was implemented with no demonstrable learning curve. EM reconstruction errors were small, correctable, and improved with calibration and control of external distortion sources; increasing confidence in the use of partially visible catheters. Image registration errors remained despite rotational alignment and deformation, and should be carefully considered.PMID:34861267 | DOI:10.1016/j.radonc.2021.11.026 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 3, 2021 Category: Radiology Authors: David Grajales Samuel Kadoury Roozbeh Shams Maroie Barkati Guila Delouya Dominic B éliveau-Nadeau Benedicte Nicolas William Trung Le Mustafa-Karim Benhacene-Boudam Daniel Juneau Jean N DaSilva Jean-Francois Carrier Gilion Hautvast Cynthia M énard Source Type: research

Radiosensitisation of SCCVII tumours and normal tissues in mice by the DNA-dependent protein kinase inhibitor AZD7648
CONCLUSION: AZD7648 is a potent radiation sensitiser of both oxic and anoxic tumour cells, but also markedly radiosensitises stem cells in the small intestine and oral mucosa.PMID:34861268 | DOI:10.1016/j.radonc.2021.11.027 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 3, 2021 Category: Radiology Authors: Cho R Hong Chantal D Buckley Way W Wong Praju V Anekal Benjamin D Dickson Gib Bogle Kevin O Hicks Michael P Hay William R Wilson Source Type: research

Gastric deformation models for adaptive radiotherapy: Personalized vs Population-based strategy
CONCLUSION: The population-based model outperformed the personalized model and demonstrated its ability in predicting filling-dependent stomach shape changes and, therefore, its potential for use in a gastric cancer LoP.PMID:34861269 | DOI:10.1016/j.radonc.2021.11.028 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 3, 2021 Category: Radiology Authors: Margot Bleeker Maarten Hulshof Arjan Bel Jan-Jakob Sonke Astrid van der Horst Source Type: research

Performance of an integrated multimodality image guidance and dose-planning system supporting tumor-targeted HDR brachytherapy for prostate cancer
CONCLUSION: The system supported tumor-targeting and was implemented with no demonstrable learning curve. EM reconstruction errors were small, correctable, and improved with calibration and control of external distortion sources; increasing confidence in the use of partially visible catheters. Image registration errors remained despite rotational alignment and deformation, and should be carefully considered.PMID:34861267 | DOI:10.1016/j.radonc.2021.11.026 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 3, 2021 Category: Radiology Authors: David Grajales Samuel Kadoury Roozbeh Shams Maroie Barkati Guila Delouya Dominic B éliveau-Nadeau Benedicte Nicolas William Trung Le Mustafa-Karim Benhacene-Boudam Daniel Juneau Jean N DaSilva Jean-Francois Carrier Gilion Hautvast Cynthia M énard Source Type: research

Radiosensitisation of SCCVII tumours and normal tissues in mice by the DNA-dependent protein kinase inhibitor AZD7648
CONCLUSION: AZD7648 is a potent radiation sensitiser of both oxic and anoxic tumour cells, but also markedly radiosensitises stem cells in the small intestine and oral mucosa.PMID:34861268 | DOI:10.1016/j.radonc.2021.11.027 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 3, 2021 Category: Radiology Authors: Cho R Hong Chantal D Buckley Way W Wong Praju V Anekal Benjamin D Dickson Gib Bogle Kevin O Hicks Michael P Hay William R Wilson Source Type: research

Gastric deformation models for adaptive radiotherapy: Personalized vs Population-based strategy
CONCLUSION: The population-based model outperformed the personalized model and demonstrated its ability in predicting filling-dependent stomach shape changes and, therefore, its potential for use in a gastric cancer LoP.PMID:34861269 | DOI:10.1016/j.radonc.2021.11.028 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 3, 2021 Category: Radiology Authors: Margot Bleeker Maarten Hulshof Arjan Bel Jan-Jakob Sonke Astrid van der Horst Source Type: research

Comment to "long term results of a phase II trial of hypofractionated adjuvant radiotherapy for early-stage breast cancer with volumetric modulated arc therapy and simultaneous integrated boost"
Radiother Oncol. 2021 Nov 29:S0167-8140(21)09012-5. doi: 10.1016/j.radonc.2021.10.024. Online ahead of print.NO ABSTRACTPMID:34856289 | DOI:10.1016/j.radonc.2021.10.024 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 2, 2021 Category: Radiology Authors: Yung-Shuo Kao Source Type: research

Comment to "long term results of a phase II trial of hypofractionated adjuvant radiotherapy for early-stage breast cancer with volumetric modulated arc therapy and simultaneous integrated boost"
Radiother Oncol. 2021 Nov 29:S0167-8140(21)09012-5. doi: 10.1016/j.radonc.2021.10.024. Online ahead of print.NO ABSTRACTPMID:34856289 | DOI:10.1016/j.radonc.2021.10.024 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 2, 2021 Category: Radiology Authors: Yung-Shuo Kao Source Type: research

Single-institution clinical experience using Robust Intensity Modulated Proton Therapy in chordoma and chondrosarcoma of the mobile spine and sacrum: feasibility and need for plan adaptation
CONCLUSIONS: Robustly optimized intensity modulated proton beam therapy for chordoma and chondrosarcoma of the mobile spine is feasible. Plan adaptations due to anatomical changes were required in approximately 23 percent of treatment courses.PMID:34843840 | DOI:10.1016/j.radonc.2021.11.020 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 29, 2021 Category: Radiology Authors: Michiel Kroesen Vesna Miladinovic Stefan A J Hutschemaekers Jenneke Jacobs Charlotte van der Vos Anne Lisa Wolf Mischa S Hoogeman Marco van Vulpen Johan L Bloem Sander P D S Dijkstra Wilco C Peul Joan J Penninkhof Augustinus D G Krol Source Type: research

A Systematic Review and Meta-Analysis of Liver Tumor Position Variability during SBRT using Various Motion Management and IGRT Strategies
CONCLUSION: Our meta-analysis suggested that weighted-mean PTV margin of 6mm might be appropriate for BH. For AC and FB, asymmetric PTV margins (weighted-mean margin = 4mm (AP), 6mm (SI/LR)) might be appropriate. For FB, if larger (> ITV margin) intra-fraction variability observed, the additional intra- and inter-fraction variability should be accounted in the PTV margin.PMID:34843841 | DOI:10.1016/j.radonc.2021.11.022 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 29, 2021 Category: Radiology Authors: Manju Sharma Tomi F Nano Meghana Akkati Michael T Milano Olivier Morin Mary Feng Source Type: research

CT-guided versus MR-guided Radiotherapy: Impact on Gastrointestinal Sparing in Adrenal Stereotactic Body Radiotherapy
CONCLUSION: Breath-hold VMAT radiotherapy provides superior target coverage and conformality over MRgRTBH, but the ability of MRgRTBH to safely provide ablative doses to adrenal lesions near mobile luminal OAR through adaptation and direct, real-time motion tracking is unmatched.PMID:34843842 | DOI:10.1016/j.radonc.2021.11.024 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 29, 2021 Category: Radiology Authors: Lori L Rodriguez Rupesh Kotecha Martin C Tom Michael D Chuong Jessika A Contreras Tino Romaguera Diane Alvarez James McCulloch Robert Herrera Rene J Hernandez Jairo Mercado Minesh P Mehta Alonso N Gutierrez Kathryn E Mittauer Source Type: research

Hyperbaric oxygen treatment of mandibular osteoradionecrosis: Combined data from the two randomized clinical trials DAHANCA-21 and NWHHT2009-1
CONCLUSION: Hyperbaric oxygen did not significantly improve the healing outcome of osteoradionecrosis after surgical removal of necrotic bone as compared to standard care (70% vs. 51%). This effect is not statistically significant due to the fact that the study was underpowered and is therefore prone to type II error.PMID:34843843 | DOI:10.1016/j.radonc.2021.11.021 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 29, 2021 Category: Radiology Authors: Lone E Forner Fran çois J Dieleman Richard J Shaw Anastasios Kanatas Chris J Butterworth G öran Kjeller Jan Alsner Jens Overgaard S øren Hillerup Ole Hyldegaard Per Arnell Christian von Buchwald Johannes H A M Kaanders Ludi E Smeele Lena Specht J ørge Source Type: research

Single-institution clinical experience using Robust Intensity Modulated Proton Therapy in chordoma and chondrosarcoma of the mobile spine and sacrum: feasibility and need for plan adaptation
CONCLUSIONS: Robustly optimized intensity modulated proton beam therapy for chordoma and chondrosarcoma of the mobile spine is feasible. Plan adaptations due to anatomical changes were required in approximately 23 percent of treatment courses.PMID:34843840 | DOI:10.1016/j.radonc.2021.11.020 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 29, 2021 Category: Radiology Authors: Michiel Kroesen Vesna Miladinovic Stefan A J Hutschemaekers Jenneke Jacobs Charlotte van der Vos Anne Lisa Wolf Mischa S Hoogeman Marco van Vulpen Johan L Bloem Sander P D S Dijkstra Wilco C Peul Joan J Penninkhof Augustinus D G Krol Source Type: research

A Systematic Review and Meta-Analysis of Liver Tumor Position Variability during SBRT using Various Motion Management and IGRT Strategies
CONCLUSION: Our meta-analysis suggested that weighted-mean PTV margin of 6mm might be appropriate for BH. For AC and FB, asymmetric PTV margins (weighted-mean margin = 4mm (AP), 6mm (SI/LR)) might be appropriate. For FB, if larger (> ITV margin) intra-fraction variability observed, the additional intra- and inter-fraction variability should be accounted in the PTV margin.PMID:34843841 | DOI:10.1016/j.radonc.2021.11.022 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 29, 2021 Category: Radiology Authors: Manju Sharma Tomi F Nano Meghana Akkati Michael T Milano Olivier Morin Mary Feng Source Type: research

CT-guided versus MR-guided Radiotherapy: Impact on Gastrointestinal Sparing in Adrenal Stereotactic Body Radiotherapy
CONCLUSION: Breath-hold VMAT radiotherapy provides superior target coverage and conformality over MRgRTBH, but the ability of MRgRTBH to safely provide ablative doses to adrenal lesions near mobile luminal OAR through adaptation and direct, real-time motion tracking is unmatched.PMID:34843842 | DOI:10.1016/j.radonc.2021.11.024 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 29, 2021 Category: Radiology Authors: Lori L Rodriguez Rupesh Kotecha Martin C Tom Michael D Chuong Jessika A Contreras Tino Romaguera Diane Alvarez James McCulloch Robert Herrera Rene J Hernandez Jairo Mercado Minesh P Mehta Alonso N Gutierrez Kathryn E Mittauer Source Type: research

Hyperbaric oxygen treatment of mandibular osteoradionecrosis: Combined data from the two randomized clinical trials DAHANCA-21 and NWHHT2009-1
CONCLUSION: Hyperbaric oxygen did not significantly improve the healing outcome of osteoradionecrosis after surgical removal of necrotic bone as compared to standard care (70% vs. 51%). This effect is not statistically significant due to the fact that the study was underpowered and is therefore prone to type II error.PMID:34843843 | DOI:10.1016/j.radonc.2021.11.021 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 29, 2021 Category: Radiology Authors: Lone E Forner Fran çois J Dieleman Richard J Shaw Anastasios Kanatas Chris J Butterworth G öran Kjeller Jan Alsner Jens Overgaard S øren Hillerup Ole Hyldegaard Per Arnell Christian von Buchwald Johannes H A M Kaanders Ludi E Smeele Lena Specht J ørge Source Type: research

Single-institution clinical experience using Robust Intensity Modulated Proton Therapy in chordoma and chondrosarcoma of the mobile spine and sacrum: feasibility and need for plan adaptation
CONCLUSIONS: Robustly optimized intensity modulated proton beam therapy for chordoma and chondrosarcoma of the mobile spine is feasible. Plan adaptations due to anatomical changes were required in approximately 23 percent of treatment courses.PMID:34843840 | DOI:10.1016/j.radonc.2021.11.020 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 29, 2021 Category: Radiology Authors: Michiel Kroesen Vesna Miladinovic Stefan A J Hutschemaekers Jenneke Jacobs Charlotte van der Vos Anne Lisa Wolf Mischa S Hoogeman Marco van Vulpen Johan L Bloem Sander P D S Dijkstra Wilco C Peul Joan J Penninkhof Augustinus D G Krol Source Type: research

A Systematic Review and Meta-Analysis of Liver Tumor Position Variability during SBRT using Various Motion Management and IGRT Strategies
CONCLUSION: Our meta-analysis suggested that weighted-mean PTV margin of 6mm might be appropriate for BH. For AC and FB, asymmetric PTV margins (weighted-mean margin = 4mm (AP), 6mm (SI/LR)) might be appropriate. For FB, if larger (> ITV margin) intra-fraction variability observed, the additional intra- and inter-fraction variability should be accounted in the PTV margin.PMID:34843841 | DOI:10.1016/j.radonc.2021.11.022 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 29, 2021 Category: Radiology Authors: Manju Sharma Tomi F Nano Meghana Akkati Michael T Milano Olivier Morin Mary Feng Source Type: research

CT-guided versus MR-guided Radiotherapy: Impact on Gastrointestinal Sparing in Adrenal Stereotactic Body Radiotherapy
CONCLUSION: Breath-hold VMAT radiotherapy provides superior target coverage and conformality over MRgRTBH, but the ability of MRgRTBH to safely provide ablative doses to adrenal lesions near mobile luminal OAR through adaptation and direct, real-time motion tracking is unmatched.PMID:34843842 | DOI:10.1016/j.radonc.2021.11.024 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 29, 2021 Category: Radiology Authors: Lori L Rodriguez Rupesh Kotecha Martin C Tom Michael D Chuong Jessika A Contreras Tino Romaguera Diane Alvarez James McCulloch Robert Herrera Rene J Hernandez Jairo Mercado Minesh P Mehta Alonso N Gutierrez Kathryn E Mittauer Source Type: research

Hyperbaric oxygen treatment of mandibular osteoradionecrosis: Combined data from the two randomized clinical trials DAHANCA-21 and NWHHT2009-1
CONCLUSION: Hyperbaric oxygen did not significantly improve the healing outcome of osteoradionecrosis after surgical removal of necrotic bone as compared to standard care (70% vs. 51%). This effect is not statistically significant due to the fact that the study was underpowered and is therefore prone to type II error.PMID:34843843 | DOI:10.1016/j.radonc.2021.11.021 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 29, 2021 Category: Radiology Authors: Lone E Forner Fran çois J Dieleman Richard J Shaw Anastasios Kanatas Chris J Butterworth G öran Kjeller Jan Alsner Jens Overgaard S øren Hillerup Ole Hyldegaard Per Arnell Christian von Buchwald Johannes H A M Kaanders Ludi E Smeele Lena Specht J ørge Source Type: research

Development of a Web-based Prognostic Model to Quantify the Survival Benefit of Cumulative Cisplatin Dose during Concurrent Chemoradiotherapy in Childhood Nasopharyngeal Carcinoma
Radiother Oncol. 2021 Nov 25:S0167-8140(21)09008-3. doi: 10.1016/j.radonc.2021.11.014. Online ahead of print.ABSTRACTPURPOSE: To quantify and predict the survival benefits of cumulative cisplatin dose during concurrent chemoradiotherapy (CC-CCD) in children and adolescents with locoregionally advanced nasopharyngeal carcinoma (CA-LANPC).MATERIALS AND METHODS: Patients with CA-LANPC who received first-line neoadjuvant chemotherapy (NAC) followed by concurrent chemoradiotherapy (CCRT) between September 2007 and April 2018 were evaluated. Recursive partitioning analyses (RPAs) helped identify the ideal thresholds of CC-CCD on...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 28, 2021 Category: Radiology Authors: Ya-Nan Jin Qian-Qiong Yang Zi-Qian Li Xue-Qing Ou Wang-Jian Zhang Tia Marks Ji-Jin Yao Liang-Ping Xia Source Type: research

Temporal Changes and Risk Factors for Esophageal Stenosis after Salvage Radiotherapy in Superficial Esophageal Cancer following Non-Curative Endoscopic Submucosal Dissection
Radiother Oncol. 2021 Nov 25:S0167-8140(21)09007-1. doi: 10.1016/j.radonc.2021.11.016. Online ahead of print.ABSTRACTBACKGROUND AND PURPOSE: Radiotherapy (RT) has recently received increasing attention as an additional treatment for organ preservation after non-curative endoscopic submucosal dissection (ESD) in patients with superficial esophageal cancer. Esophageal stenosis is an adverse event related to RT after ESD that is not widely studied. The aim of this study was to investigate esophageal stenosis related to salvage RT in superficial esophageal cancer after non-curative ESD.MATERIALS AND METHODS: Fifty patients who...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 28, 2021 Category: Radiology Authors: Ikuno Nishibuchi Yuji Murakami Katsumaro Kubo Nobuki Imano Yuki Takeuchi Yuji Urabe Shiro Oka Shinji Tanaka Yasushi Nagata Source Type: research

Postoperative Radiotherapy in Stage I-III Merkel Cell Carcinoma
CONCLUSIONS: PORT was associated with less recurrences and improved OS in patients with stage I-III MCC, but not with improved MCC-related survival. Trends in OS benefit are likely to be caused by selection bias suggesting further refinement of criteria for PORT is warranted, for instance by taking life expectancy into account.PMID:34838887 | DOI:10.1016/j.radonc.2021.11.017 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 28, 2021 Category: Radiology Authors: Sonja Levy Stephanie A Blankenstein Dirk Jan Gr ünhagen Mathilde Jalving Olga Hamming-Vrieze Lukas B Been Lisa Tans Alexander C J van Akkooi Margot E T Tesselaar Source Type: research

Patterns and Predictors of Relapse in Merkel Cell Carcinoma: Results from a Population-Based Study
CONCLUSIONS: Adjuvant RT improvedRFS, withoutimpact on MCC-SS and OS. Co-morbidity rather than RT influenced OS. Adjuvant RT may be avoided instage I patients with negative SLNB and no associated high-risk factors. Prophylactic RNI could be considered in stage II with high risk features, inspite of negative SLNB. Stage III patients benefited from adjuvant RNI, but no impact on prevention of DM.PMID:34838888 | DOI:10.1016/j.radonc.2021.11.015 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 28, 2021 Category: Radiology Authors: Kurian Joseph Justina Wong Aswin Abraham Julia Zebak Anushree Patel Aoife Jones Thachuthara Umar Iqbal Truong-Minh Pham Anjali Menon Sunita Ghosh Heather Warkentin John Walker Naresh Jha Salman Faruqi Thomas G Salopek Michael Smylie Source Type: research

Quality of life, HPV-status and phase angle predict survival in head and neck cancer patients under (chemo)radiotherapy undergoing nutritional intervention: Results from the prospective randomized HEADNUT-trial
CONCLUSIONS: Factors influencing overall survival in patients with HNSCC undergoing (chemo)radiotherapy are complex and multifactorial. We were able to identify QoL-related (dental problems), clinical (HPV status) and nutritional (phase angle) factors as negative predictors for survival. This study was registered within the German Clinical Trials Register (DRKS00016862).PMID:34838889 | DOI:10.1016/j.radonc.2021.11.011 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 28, 2021 Category: Radiology Authors: Laura Magdalena Kutz Jakob Abel Diana Schweizer Silke Tribius Andreas Kr üll Cordula Petersen Anastassia L öser Source Type: research

The clinical efficacy of low-dose whole-lung irradiation in moderate-to-severe COVID-19 pneumonia: RTMX-20 trial
Radiother Oncol. 2021 Nov 25:S0167-8140(21)09006-X. doi: 10.1016/j.radonc.2021.11.013. Online ahead of print.NO ABSTRACTPMID:34838890 | DOI:10.1016/j.radonc.2021.11.013 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 28, 2021 Category: Radiology Authors: C S Ortiz D Hern ández C Trujillo D Calder ón P Esqueda F Calva A Betancourt M Ram írez G Cervantes M A Souto J G Celis L R Nolazco A Olmos Source Type: research

The Radiotherapy Quality Assurance Gap Among Phase III Cancer Clinical Trials
This study investigated the utilization of QA among randomized controlled trials that involve radiotherapy (RT).METHODS AND MATERIALS: We searched ClinicalTrials.gov in February 2020 for all phase III oncology randomized clinical trials (RCTs). These trials were screened for RT-specific RCTs that had published primary trial results. Information regarding QA in each trial was collected from the study publications and trial protocol if available. Two individuals independently performed trial screening and data collection. Pearson's Chi-square tests analyses were used to assess factors that were associated with QA inclusion i...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 28, 2021 Category: Radiology Authors: Kelsey L Corrigan Stephen Kry Rebecca M Howell Ramez Kouzy Joseph Abi Jaoude Roshal R Patel Anuja Jhingran Cullen Taniguchi Albert C Koong Mary Fran McAleer Paige Nitsch Claus R ödel Emmanouil Fokas Bruce D Minsky Prajnan Das C David Fuller Ethan B Ludmi Source Type: research

Heterogeneous immunogenicity of SARS-CoV-2 vaccines in cancer patients receiving radiotherapy
Radiother Oncol. 2021 Nov 25:S0167-8140(21)09005-8. doi: 10.1016/j.radonc.2021.11.012. Online ahead of print.ABSTRACTThe immunogenicity of SARS-CoV-2 vaccines in cancer patients receiving radiotherapy is unknown. This prospective cohort study demonstrates that anti-SARS-CoV-2 spike antibody and neutralization titers are reduced in a subset of thoracic radiotherapy patients, possibly due to immunosuppressive conditions. Antibody testing may be useful to identify candidates for additional vaccine doses.PMID:34838892 | DOI:10.1016/j.radonc.2021.11.012 (Source: Radiotherapy and Oncology : journal of the European Society for Th...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 28, 2021 Category: Radiology Authors: Cynthia L Bowes Vivek Naranbhai Kerri J St Denis Evan C Lam Brittany Bertaux Florence K Keane Melin J Khandekar Alejandro B Balazs John A Iafrate Justin F Gainor Henning Willers Source Type: research

An Examination of Nationwide Trends in Accelerated Partial Breast Irradiation - The Replacement of Breast Brachytherapy with Intraoperative Radiotherapy and External Beam Radiation
Radiother Oncol. 2021 Nov 25:S0167-8140(21)09013-7. doi: 10.1016/j.radonc.2021.11.019. Online ahead of print.ABSTRACTPURPOSE: To examine recent modality utilization trends in accelerated partial breast irradiation (APBI) in the National Cancer Database (NCDB) based on the American Society for Radiation Oncology (ASTRO) guidelines.MATERIALS AND METHODS: A total of 58,194 patients treated with APBI were identified. Patients were segregated by APBI modality (brachytherapy, external beam radiotherapy [EBRT], and intraoperative radiotherapy ([IORT]). These patients were then further classified by suitability to receive APBI bas...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 28, 2021 Category: Radiology Authors: Colton Ladbury Jason Liu Eric Radany Nayana Vora Arya Amini Sushil Beriwal Catheryn Yashar Chirag Shah Scott Glaser Source Type: research

Development of a Web-based Prognostic Model to Quantify the Survival Benefit of Cumulative Cisplatin Dose during Concurrent Chemoradiotherapy in Childhood Nasopharyngeal Carcinoma
Radiother Oncol. 2021 Nov 25:S0167-8140(21)09008-3. doi: 10.1016/j.radonc.2021.11.014. Online ahead of print.ABSTRACTPURPOSE: To quantify and predict the survival benefits of cumulative cisplatin dose during concurrent chemoradiotherapy (CC-CCD) in children and adolescents with locoregionally advanced nasopharyngeal carcinoma (CA-LANPC).MATERIALS AND METHODS: Patients with CA-LANPC who received first-line neoadjuvant chemotherapy (NAC) followed by concurrent chemoradiotherapy (CCRT) between September 2007 and April 2018 were evaluated. Recursive partitioning analyses (RPAs) helped identify the ideal thresholds of CC-CCD on...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 28, 2021 Category: Radiology Authors: Ya-Nan Jin Qian-Qiong Yang Zi-Qian Li Xue-Qing Ou Wang-Jian Zhang Tia Marks Ji-Jin Yao Liang-Ping Xia Source Type: research

Temporal Changes and Risk Factors for Esophageal Stenosis after Salvage Radiotherapy in Superficial Esophageal Cancer following Non-Curative Endoscopic Submucosal Dissection
Radiother Oncol. 2021 Nov 25:S0167-8140(21)09007-1. doi: 10.1016/j.radonc.2021.11.016. Online ahead of print.ABSTRACTBACKGROUND AND PURPOSE: Radiotherapy (RT) has recently received increasing attention as an additional treatment for organ preservation after non-curative endoscopic submucosal dissection (ESD) in patients with superficial esophageal cancer. Esophageal stenosis is an adverse event related to RT after ESD that is not widely studied. The aim of this study was to investigate esophageal stenosis related to salvage RT in superficial esophageal cancer after non-curative ESD.MATERIALS AND METHODS: Fifty patients who...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 28, 2021 Category: Radiology Authors: Ikuno Nishibuchi Yuji Murakami Katsumaro Kubo Nobuki Imano Yuki Takeuchi Yuji Urabe Shiro Oka Shinji Tanaka Yasushi Nagata Source Type: research

Postoperative Radiotherapy in Stage I-III Merkel Cell Carcinoma
CONCLUSIONS: PORT was associated with less recurrences and improved OS in patients with stage I-III MCC, but not with improved MCC-related survival. Trends in OS benefit are likely to be caused by selection bias suggesting further refinement of criteria for PORT is warranted, for instance by taking life expectancy into account.PMID:34838887 | DOI:10.1016/j.radonc.2021.11.017 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 28, 2021 Category: Radiology Authors: Sonja Levy Stephanie A Blankenstein Dirk Jan Gr ünhagen Mathilde Jalving Olga Hamming-Vrieze Lukas B Been Lisa Tans Alexander C J van Akkooi Margot E T Tesselaar Source Type: research

Patterns and Predictors of Relapse in Merkel Cell Carcinoma: Results from a Population-Based Study
CONCLUSIONS: Adjuvant RT improvedRFS, withoutimpact on MCC-SS and OS. Co-morbidity rather than RT influenced OS. Adjuvant RT may be avoided instage I patients with negative SLNB and no associated high-risk factors. Prophylactic RNI could be considered in stage II with high risk features, inspite of negative SLNB. Stage III patients benefited from adjuvant RNI, but no impact on prevention of DM.PMID:34838888 | DOI:10.1016/j.radonc.2021.11.015 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 28, 2021 Category: Radiology Authors: Kurian Joseph Justina Wong Aswin Abraham Julia Zebak Anushree Patel Aoife Jones Thachuthara Umar Iqbal Truong-Minh Pham Anjali Menon Sunita Ghosh Heather Warkentin John Walker Naresh Jha Salman Faruqi Thomas G Salopek Michael Smylie Source Type: research

Quality of life, HPV-status and phase angle predict survival in head and neck cancer patients under (chemo)radiotherapy undergoing nutritional intervention: Results from the prospective randomized HEADNUT-trial
CONCLUSIONS: Factors influencing overall survival in patients with HNSCC undergoing (chemo)radiotherapy are complex and multifactorial. We were able to identify QoL-related (dental problems), clinical (HPV status) and nutritional (phase angle) factors as negative predictors for survival. This study was registered within the German Clinical Trials Register (DRKS00016862).PMID:34838889 | DOI:10.1016/j.radonc.2021.11.011 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 28, 2021 Category: Radiology Authors: Laura Magdalena Kutz Jakob Abel Diana Schweizer Silke Tribius Andreas Kr üll Cordula Petersen Anastassia L öser Source Type: research

The clinical efficacy of low-dose whole-lung irradiation in moderate-to-severe COVID-19 pneumonia: RTMX-20 trial
Radiother Oncol. 2021 Nov 25:S0167-8140(21)09006-X. doi: 10.1016/j.radonc.2021.11.013. Online ahead of print.NO ABSTRACTPMID:34838890 | DOI:10.1016/j.radonc.2021.11.013 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 28, 2021 Category: Radiology Authors: C S Ortiz D Hern ández C Trujillo D Calder ón P Esqueda F Calva A Betancourt M Ram írez G Cervantes M A Souto J G Celis L R Nolazco A Olmos Source Type: research

The Radiotherapy Quality Assurance Gap Among Phase III Cancer Clinical Trials
This study investigated the utilization of QA among randomized controlled trials that involve radiotherapy (RT).METHODS AND MATERIALS: We searched ClinicalTrials.gov in February 2020 for all phase III oncology randomized clinical trials (RCTs). These trials were screened for RT-specific RCTs that had published primary trial results. Information regarding QA in each trial was collected from the study publications and trial protocol if available. Two individuals independently performed trial screening and data collection. Pearson's Chi-square tests analyses were used to assess factors that were associated with QA inclusion i...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 28, 2021 Category: Radiology Authors: Kelsey L Corrigan Stephen Kry Rebecca M Howell Ramez Kouzy Joseph Abi Jaoude Roshal R Patel Anuja Jhingran Cullen Taniguchi Albert C Koong Mary Fran McAleer Paige Nitsch Claus R ödel Emmanouil Fokas Bruce D Minsky Prajnan Das C David Fuller Ethan B Ludmi Source Type: research

Heterogeneous immunogenicity of SARS-CoV-2 vaccines in cancer patients receiving radiotherapy
Radiother Oncol. 2021 Nov 25:S0167-8140(21)09005-8. doi: 10.1016/j.radonc.2021.11.012. Online ahead of print.ABSTRACTThe immunogenicity of SARS-CoV-2 vaccines in cancer patients receiving radiotherapy is unknown. This prospective cohort study demonstrates that anti-SARS-CoV-2 spike antibody and neutralization titers are reduced in a subset of thoracic radiotherapy patients, possibly due to immunosuppressive conditions. Antibody testing may be useful to identify candidates for additional vaccine doses.PMID:34838892 | DOI:10.1016/j.radonc.2021.11.012 (Source: Radiotherapy and Oncology : journal of the European Society for Th...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 28, 2021 Category: Radiology Authors: Cynthia L Bowes Vivek Naranbhai Kerri J St Denis Evan C Lam Brittany Bertaux Florence K Keane Melin J Khandekar Alejandro B Balazs John A Iafrate Justin F Gainor Henning Willers Source Type: research

An Examination of Nationwide Trends in Accelerated Partial Breast Irradiation - The Replacement of Breast Brachytherapy with Intraoperative Radiotherapy and External Beam Radiation
Radiother Oncol. 2021 Nov 25:S0167-8140(21)09013-7. doi: 10.1016/j.radonc.2021.11.019. Online ahead of print.ABSTRACTPURPOSE: To examine recent modality utilization trends in accelerated partial breast irradiation (APBI) in the National Cancer Database (NCDB) based on the American Society for Radiation Oncology (ASTRO) guidelines.MATERIALS AND METHODS: A total of 58,194 patients treated with APBI were identified. Patients were segregated by APBI modality (brachytherapy, external beam radiotherapy [EBRT], and intraoperative radiotherapy ([IORT]). These patients were then further classified by suitability to receive APBI bas...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 28, 2021 Category: Radiology Authors: Colton Ladbury Jason Liu Eric Radany Nayana Vora Arya Amini Sushil Beriwal Catheryn Yashar Chirag Shah Scott Glaser Source Type: research

Deep learning-based GTV contouring modeling inter- and intra-observer variability in sarcomas
CONCLUSION: Results demonstrate the ability of the proposed method to predict accurate contours while utilizing variability and as such it can be used to improve clinical workflow.PMID:34808228 | DOI:10.1016/j.radonc.2021.09.034 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 22, 2021 Category: Radiology Authors: Thibault Marin Yue Zhuo Rita Maria Lahoud Fei Tian Xiaoyue Ma Fangxu Xing Maryam Moteabbed Xiaofeng Liu Kira Grogg Nadya Shusharina Jonghye Woo Chao Ma Yen-Lin E Chen Georges El Fakhri Source Type: research

Deep learning-based GTV contouring modeling inter- and intra-observer variability in sarcomas
CONCLUSION: Results demonstrate the ability of the proposed method to predict accurate contours while utilizing variability and as such it can be used to improve clinical workflow.PMID:34808228 | DOI:10.1016/j.radonc.2021.09.034 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 22, 2021 Category: Radiology Authors: Thibault Marin Yue Zhuo Rita Maria Lahoud Fei Tian Xiaoyue Ma Fangxu Xing Maryam Moteabbed Xiaofeng Liu Kira Grogg Nadya Shusharina Jonghye Woo Chao Ma Yen-Lin E Chen Georges El Fakhri Source Type: research

Deep learning-based GTV contouring modeling inter- and intra-observer variability in sarcomas
CONCLUSION: Results demonstrate the ability of the proposed method to predict accurate contours while utilizing variability and as such it can be used to improve clinical workflow.PMID:34808228 | DOI:10.1016/j.radonc.2021.09.034 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 22, 2021 Category: Radiology Authors: Thibault Marin Yue Zhuo Rita Maria Lahoud Fei Tian Xiaoyue Ma Fangxu Xing Maryam Moteabbed Xiaofeng Liu Kira Grogg Nadya Shusharina Jonghye Woo Chao Ma Yen-Lin E Chen Georges El Fakhri Source Type: research

Deep learning-based GTV contouring modeling inter- and intra-observer variability in sarcomas
CONCLUSION: Results demonstrate the ability of the proposed method to predict accurate contours while utilizing variability and as such it can be used to improve clinical workflow.PMID:34808228 | DOI:10.1016/j.radonc.2021.09.034 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 22, 2021 Category: Radiology Authors: Thibault Marin Yue Zhuo Rita Maria Lahoud Fei Tian Xiaoyue Ma Fangxu Xing Maryam Moteabbed Xiaofeng Liu Kira Grogg Nadya Shusharina Jonghye Woo Chao Ma Yen-Lin E Chen Georges El Fakhri Source Type: research

Deep learning-based GTV contouring modeling inter- and intra-observer variability in sarcomas
CONCLUSION: Results demonstrate the ability of the proposed method to predict accurate contours while utilizing variability and as such it can be used to improve clinical workflow.PMID:34808228 | DOI:10.1016/j.radonc.2021.09.034 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 22, 2021 Category: Radiology Authors: Thibault Marin Yue Zhuo Rita Maria Lahoud Fei Tian Xiaoyue Ma Fangxu Xing Maryam Moteabbed Xiaofeng Liu Kira Grogg Nadya Shusharina Jonghye Woo Chao Ma Yen-Lin E Chen Georges El Fakhri Source Type: research

Radiomics outperforms semantic features for prediction of response to stereotactic radiosurgery in brain metastases
CONCLUSION: The developed radiomics model allowed prediction of early response to radiosurgery in patients with brain metastases and outperformed the visual assessment of patterns of contrast enhancement.PMID:34801629 | DOI:10.1016/j.radonc.2021.11.010 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 21, 2021 Category: Radiology Authors: Robin Gutsche Philipp Lohmann Mauritius Hoevels Daniel Ruess Norbert Galldiks Veerle Visser-Vanderwalle Harald Treuer Maximilian Ruge Martin Kocher Source Type: research

Radiomics outperforms semantic features for prediction of response to stereotactic radiosurgery in brain metastases
CONCLUSION: The developed radiomics model allowed prediction of early response to radiosurgery in patients with brain metastases and outperformed the visual assessment of patterns of contrast enhancement.PMID:34801629 | DOI:10.1016/j.radonc.2021.11.010 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 21, 2021 Category: Radiology Authors: Robin Gutsche Philipp Lohmann Mauritius Hoevels Daniel Ruess Norbert Galldiks Veerle Visser-Vanderwalle Harald Treuer Maximilian Ruge Martin Kocher Source Type: research