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PMID: 32681929 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 14, 2020 Category: Radiology Authors: Franco P, Tesio V, Castelli L Tags: Radiother Oncol Source Type: research

Training and validation of a robust PET radiomic-based index to predict distant-relapse-free-survival after radio-chemotherapy for locally advanced pancreatic cancer.
CONCLUSIONS: A radiomic-based index including only two robust PET-RFs predicted DRFS of LAPC patients after radio-chemotherapy. The current results could find relevant applications in the treatment personalization of LAPC. A multi-institution independent validation has been planned. PMID: 32681930 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 14, 2020 Category: Radiology Authors: Mori M, Passoni P, Incerti E, Bettinardi V, Broggi S, Reni M, Whybra P, Spezi E, Vanoli EG, Gianolli L, Picchio M, Di Muzio NG, Fiorino C Tags: Radiother Oncol Source Type: research

Thoracic Radiotherapy As A Risk Factor For Heart Ischemia In Subjects Treated With Chest Irradiation And Chemotherapy And Without Classic Cardiovascular RISK Factors.
Abstract BACKGROUND AND PURPOSE: Radiation Induced Heart Disease (RIHD) represents a late effect of chest irradiation, contributing in increasing mortality rate in oncological patients by affecting pericardium, myocardium, valvs and coronaries. Currently, regarding the risk of Coronary Artery Disease (CAD), a cardiological screening involving exercise stress electrocardiography after 5-10 years from radiotherapy is advised. We sought to determine the rate of ischemia at exercise stress electrocardiography in a population of patients without cardiovascular risk factors who sustained radiotherapy, using a cohort of ...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 13, 2020 Category: Radiology Authors: Vallerio P, Maloberti A, Palazzini M, Occhi L, Peretti A, Nava S, Soriano F, Musca F, DE Chiara B, Belli O, Moreo A, Bisceglia I, Lestuzzi C, Giannattasio C Tags: Radiother Oncol Source Type: research

Outcome and patterns of radiation associated brain image changes after proton therapy for head and neck skull base cancers.
CONCLUSION: Small RAIC lesions after PT occurred in 17.3% of the patients; the majority in nasopharyngeal or sinonasal cancer. The estimated dose-volume correlations confirm the importance of minimizing focal high doses to brain when achievable. PMID: 32679304 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 13, 2020 Category: Radiology Authors: May Engeseth G, Stieb S, Sherif Radwan Mohamed A, He R, Hanquist Stokkevåg C, Brydøy M, Dave Fuller C, Garden AS, I Rosenthal D, Phan J, Morrison WH, Reddy JP, Wu R, Zhang X, Jay Frank S, Brandon Gunn G Tags: Radiother Oncol Source Type: research

Dose-volume effects of breast cancer radiation therapy on the risk of second oesophageal cancer.
CONCLUSION: This first study investigating the relationship between oesophagus dose-volume distribution and oesophageal cancer risk showed an increased risk per Gy for Dmedian with larger volumes irradiated at high doses. While current techniques allows better oesophagus sparing, constraints applied to Dmedian and V30 could potentially further reduce the risk of oesophageal cancer. PMID: 32679305 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 13, 2020 Category: Radiology Authors: Journy N, Schonfeld SJ, Hauptmann M, Roberti S, Howell RM, Smith SA, Vaalavirta L, Stovall M, van Leeuwen FE, Weathers RE, Hodgson D, Gilbert ES, Berrington de Gonzalez A, Morton LM Tags: Radiother Oncol Source Type: research

Intraoperative radiation therapy (IORT) for soft tissue sarcoma - ESTRO IORT Task Force / ACROP recommendations.
CONCLUSIONS: IORT-containing approaches result in high rates of local control with low to acceptable toxicity rates. Based on the available evidence, we made recommendations for the use of IORT in STS. Clinicians and researchers are encouraged to use these guidelines in clinical routine as well as in the design of future trials. PMID: 32679306 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 13, 2020 Category: Radiology Authors: Roeder F, Morillo V, Saleh-Ebrahimi L, Calvo FA, Poortmans P, Ferrer Albiach C Tags: Radiother Oncol Source Type: research

The use of simulation-CT's as acoronavirus disease 2019screening tool during thesevere acute respiratory syndrome coronavirus 2pandemic.
PMID: 32679307 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 13, 2020 Category: Radiology Authors: Nevens D, Billiet C, Weytjens R, Joye I, Machiels M, Vermylen A, Chiari I, Bauwens W, Vemeulen P, Dirix L, Huget P, Verellen D, Dirix P, Meijnders P Tags: Radiother Oncol Source Type: research

A Tumor-Immune Interaction Model for Hepatocellular Carcinoma based on measured Lymphocyte Counts in Patients undergoing Radiotherapy.
CONCLUSIONS: This study introduces a mathematical model for tumor-immune interactions using clinically extracted radiotherapy patient data, which can be applied to design trials aimed at minimizing lymphocyte depleting effects in radiation therapy. PMID: 32679308 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 13, 2020 Category: Radiology Authors: Sung W, Grassberger C, McNamara AL, Basler L, Ehrbar S, Tanadini-Lang S, Hong TS, Paganetti H Tags: Radiother Oncol Source Type: research

Brachytherapy in Belgium in 2018. A national survey of the brachytherapy study group of the Belgian SocieTy for Radiotherapy and Oncology (BeSTRO).
PMID: 32679309 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 13, 2020 Category: Radiology Authors: Salembier C, De Hertogh O, Daisne JF, Palumbo S, Van Gestel D Tags: Radiother Oncol Source Type: research

Prognostic significance of quantitative metastatic lymph node burden on magnetic resonance imaging in nasopharyngeal carcinoma:a retrospective study of 1224 patients from two centers.
CONCLUSIONS: The number of MRI-positive LNs was a predominant independent prognostic factor for NPC patients' survival. It may be incorporated into the future N-staging system to improve its accuracy in predicting outcomes. PMID: 32679310 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 13, 2020 Category: Radiology Authors: Ma H, Liang S, Cui C, Zhang Y, Xie F, Zhou J, Dong A, Chen M, Xie C, Li H, Liu L Tags: Radiother Oncol Source Type: research

The analysis of absorbed dose by pancreas during gastric cancer radiotherapy.
PMID: 32679311 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 13, 2020 Category: Radiology Authors: Polanowski P, Wydmański J, Tukiendorf A, Składowski K Tags: Radiother Oncol Source Type: research

The importance of IL-6 blockade beyond the COVID-19 pandemic: consideration for cancer care.
PMID: 32673773 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 12, 2020 Category: Radiology Authors: Carlo Iorio G, Ricardi U, Franco P Tags: Radiother Oncol Source Type: research

Response to Chai' letter: What caused the difference in prognosis among different physicians?
PMID: 32673774 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 12, 2020 Category: Radiology Authors: Qiu X, Xu T, Li M, Fei Z, Chen C Tags: Radiother Oncol Source Type: research

Response to, "Role of neoadjuvant radiochemotherapy for esophageal cancers over pre/peri-operative chemotherapy in the era of COVID-19 and beyond".
Response to, "Role of neoadjuvant radiochemotherapy for esophageal cancers over pre/peri-operative chemotherapy in the era of COVID-19 and beyond". Radiother Oncol. 2020 Jul 13;: Authors: Tchelebi LT, Goodman K PMID: 32673775 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 12, 2020 Category: Radiology Authors: Tchelebi LT, Goodman K Tags: Radiother Oncol Source Type: research

Role of neoadjuvant radiochemotherapy for esophageal cancers over pre/peri-operative chemotherapy in the era of COVID-19 and beyond.
PMID: 32673776 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 12, 2020 Category: Radiology Authors: Cellini F, Antonietta Gambacorta M, Carlo Mattiucci G, Valentini V Tags: Radiother Oncol Source Type: research

ESTRO ACROP guidelines for Target Volume Definition in the thoracic radiation treatment of Small cell lung cancer.
e U Abstract Radiotherapy (RT) plays a major role in the treatment of small cell lung cancer (SCLC). Therefore, the ACROP committee was asked by ESTRO to provide recommendations on target volume delineation for standard clinical scenarios in definitive (chemo)-radiotherapy (CRT), adjuvant RT for stages I-III SCLC and consolidation thoracic RT for stage IV disease. The aim of these guidelines is to standardise and optimise the process of RT treatment planning for clinical practice and prospective studies. The process for the development of the guidelines included the evaluation of a structured questionnaire followe...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 12, 2020 Category: Radiology Authors: Le Pechoux C, Faivre-Finn C, Ramella S, McDonald F, Manapov F, Martin Putora P, Slotman B, De Ruysscher D, Ricardi U, Geets X, Belderbos J, Pöttgen C, Dziadiuszko R, Peeters S, Lievens Y, Hurkmans C, Van Houtte P, Nestle U Tags: Radiother Oncol Source Type: research

Comment on professional quality of life and burnout amongst radiation oncologists: the impact of alexithymia and empathy.
PMID: 32673778 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 12, 2020 Category: Radiology Authors: Franzcr JL Tags: Radiother Oncol Source Type: research

Management of gynecologic cancer: choosing radiotherapy wisely by 3 Southern Ontario academic centers during the COVID-19 pandemic.
PMID: 32673779 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 12, 2020 Category: Radiology Authors: Han K, Mendez L, D'Souza D, Velker V, Barnes E, Milosevic MF, Fyles A, Ferguson SE, Taggar A, Croke J, Donovan E, Leung E Tags: Radiother Oncol Source Type: research

Letter to the editor regarding the article "Selection of a high-level physician may help improve outcomes of nasopharyngeal carcinoma" by Fei et al.
Letter to the editor regarding the article "Selection of a high-level physician may help improve outcomes of nasopharyngeal carcinoma" by Fei et al. Radiother Oncol. 2020 Jul 13;: Authors: Hong Rim C PMID: 32673780 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 12, 2020 Category: Radiology Authors: Hong Rim C Tags: Radiother Oncol Source Type: research

Clarifications on our review on estimating dose delivery accuracy in stereotactic body radiation therapy: a review of in-vivo measurement methods: in response to the letter of Kos.
PMID: 32663534 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 10, 2020 Category: Radiology Authors: Esposito M, Villaggi E, Bresciani S, Cilla S, Falco MD, Garibaldi C, Russo S, Talamonti C, Stasi M, Mancosu P Tags: Radiother Oncol Source Type: research

Cardiac sub-volume targeting demonstrates regional radiosensitivity in the mouse heart.
Abstract BACKGROUND AND PURPOSE: Radiation-induced cardiac toxicity (RICT) remains one of the most critical dose limiting constraints in radiotherapy. Recent studies have shown higher doses to the base of the heart are associated with worse overall survival in lung cancer patients receiving radiotherapy. This work aimed to investigate the impact of sub-volume heart irradiation in a mouse model using small animal image-guided radiotherapy. MATERIALS AND METHODS: C57BL/6 mice were irradiated with a single fraction of 16 Gy to the base, middle or apex of the heart using a small animal radiotherapy research platf...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 10, 2020 Category: Radiology Authors: Ghita M, Gill EK, Walls GM, Edgar KS, McMahon SJ, Osorio EV, Bergom C, Grieve DJ, Watson CJ, McWilliam A, Aznar M, van Herk M, Williams KJ, Butterworth KT Tags: Radiother Oncol Source Type: research

Impact of a global radiation oncology scholarship for trainees: An evaluation of early outcomes.
We report on early outcomes of a Canadian Global Oncology elective scholarship program for trainees (2014-2019). The number of global oncology electives increased. Academic deliverables and collaborations were observed. There was evidence of personal and professional development. PMID: 32663536 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 10, 2020 Category: Radiology Authors: Vulpe H, Pereira IJ, Bourque JM, Huang F, Adleman J, Rodin D, Kuk J, Goulart J, Chan J, Wakefield D, Hanna TP Tags: Radiother Oncol Source Type: research

Prostate-specific antigen kinetics and biochemical control following stereotactic body radiation therapy, high dose rate brachytherapy, and low dose rate brachytherapy: A multi-institutional analysis of 3,502 patients.
ettig MB, Chang AJ, Jackson WC, Spratt DE, Lehrer E, Zaorsky NG, Kupelian PA, Steinberg ML, Horwitz EM, Jiang NY, Kishan AU Abstract BACKGROUND AND PURPOSE: Stereotactic body radiation therapy (SBRT), low dose rate brachytherapy (LDR-BT) and high dose rate brachytherapy (HDR-BT) are ablative-intent radiotherapy options for prostate cancer (PCa). These vary considerably in dose delivery, which may impact post-treatment prostate-specific antigen (PSA) patterns and biochemical control. We compared PSA kinetics between SBRT, HDR-BT, and LDR-BT, and assessed their relationships to biochemical recurrence-free survival (...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 10, 2020 Category: Radiology Authors: Levin-Epstein R, Cook RR, Wong JK, Stock RG, Jeffrey Demanes D, Collins SP, Aghdam N, Suy S, Mantz C, Katz AJ, Nickols NG, Miszczyk L, Napieralska A, Namysl-Kaletka A, Prionas ND, Bagshaw H, Buyyounouski MK, Cao M, Mahal BA, Shabsovich D, Dang A, Yuan Y, Tags: Radiother Oncol Source Type: research

Weekly robustness evaluation of intensity-modulated proton therapy for oesophageal cancer.
CONCLUSION: IMPT reduces the dose to OARs significantly, while achieving adequate target coverage in the majority of patients. Re-planning was necessary for both IMPT and VMAT due to anatomical changes. PMID: 32663538 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 10, 2020 Category: Radiology Authors: Anakotta RM, van der Laan HP, Visser S, Ribeiro CO, Dieters M, Langendijk JA, Both S, Korevaar EW, Sijtsema NM, Knopf A, Muijs CT Tags: Radiother Oncol Source Type: research

Health-related quality of life after accelerated breast irradiation in five fractions: a comparison with fifteen fractions.
CONCLUSION: Radiotherapy in 5 fractions over 10-12 days results in more improvement and less deterioration of HRQoL than a 15 fractions schedule over 3 weeks. PMID: 32663539 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 10, 2020 Category: Radiology Authors: Van Hulle H, Vakaet V, Bultijnck R, Deseyne P, Schoepen M, Van Greveling A, Post G, De Neve W, Monten C, Lievens Y, Veldeman L Tags: Radiother Oncol Source Type: research

The gimbaled-head radiotherapy system: Rise and downfall of a dedicated system for dynamic tumour tracking with real-time monitoring and dynamic wavearc.
Abstract A gimbaled-head radiotherapy device was developed by industry-academic collaborations, with a concept of robust structures whilst maintaining high flexibilities, and its clinical application started in 2008. The unique structures with multi-image guidance functions initiated 2 new treatment modalities. One is dynamic tumor tracking radiotherapy with real time monitoring (DTTRM), which enables 4-D radiotherapy without prolongation of radiotherapy treatment time. This treatment has become clinically feasible for stereotactic body radiotherapy (SBRT) of lung cancers and liver tumors, and intensity-modulated ...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 9, 2020 Category: Radiology Authors: Hiraoka M, Mizowaki T, Matsuo Y, Nakamura M, Verellen D Tags: Radiother Oncol Source Type: research

Letter to the editor of radiotherapy and oncology regarding the article esposito et al: Estimating dose delivery accuracy in stereotactic body radiation therapy: a review of in-vivo measurement methods.
PMID: 32653600 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 8, 2020 Category: Radiology Authors: Kos S Tags: Radiother Oncol Source Type: research

A deep learning MR-based radiomic nomogram may predict survival for nasopharyngeal carcinoma patients with stage T3N1M0.
Abstract PURPOSE: To estimate the prognostic value of deep learning (DL) magnetic resonance (MR)-based radiomics for stage T3N1M0 nasopharyngeal carcinoma (NPC) patients receiving induction chemotherapy (ICT) prior to concurrent chemoradiotherapy (CCRT). METHODS: A total of 638 stage T3N1M0 NPC patients (training cohort: n = 447; test cohort: n = 191) were enrolled and underwent MRI scans before receiving ICT+CCRT. From the pretreatment MR images, DL-based radiomic signatures were developed to predict disease-free survival (DFS) in an end-to-end way. Incorporating independent clinical prognostic parameters an...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 3, 2020 Category: Radiology Authors: Zhong LZ, Fang XL, Dong D, Peng H, Fang MJ, Huang CL, He BX, Lin L, Ma J, Tang LL, Tian J Tags: Radiother Oncol Source Type: research

4D CT analysis of organs at risk (OARs) in stereotactic radiotherapy.
Abstract Internal organs at risk volumes (IRV) represent the propagation of organs at risk (OARs) in 4DCT. Sixty consecutive patients that underwent 4DCT for thoracic stereotactic radiotherapy were analyzed and IRVs for heart, trachea, esophagus, bronchial tree, great vessels, and spinal cord were calculated. IRVs were then tested for the respect of dose constraints. IRVs were significantly bigger than standard OARs (p-value
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 1, 2020 Category: Radiology Authors: Nardone V, Maria Giugliano F, Reginelli A, Sangiovanni A, Mormile M, Iadanza L, Cappabianca S, Guida C Tags: Radiother Oncol Source Type: research

Measurement of circulating free DNA in squamous cell carcinoma of the anus and relation to risk factors and recurrence.
Spindler KL Abstract BACKGROUND: Measuring circulating-free-deoxyribonucleic-acid (cfDNA) has created a new framework for personalized treatment in oncology. The aim of this study was to analyze the relation between cfDNA and risk factors and outcome in squamous cell carcinoma of the anus (SCCA). METHODS: Patients treated with radiotherapy for localized SCCA were included in Aarhus, Denmark from 2016 -2019. Serum samples from baseline, during and after therapy, were measured for the level of cfDNA in copies per mL by a direct fluorescent assay. RESULTS: Eighty patients were included. Samples were availab...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 1, 2020 Category: Radiology Authors: Cecilie Lefèvre A, Kronborg C, Singers Sørensen B, Rasmus Palmelund Krag S, Serup-Hansen E, Garm Spindler KL Tags: Radiother Oncol Source Type: research

Prostate intrafraction motion during the preparation and delivery of MR-guided radiotherapy sessions on a 1.5T MR-Linac.
CONCLUSION: This is the first study to investigate prostate intrafraction motions during entire MR-guided RT sessions on an MR-Linac. We have shown that high quality 3D cine-MR imaging and prostate tracking during RT is feasible with beam-on. The clinically applied margins of 5 mm have proven to be sufficient for these treatments and may potentially be further reduced using intrafraction plan adaptation guided by cine-MR imaging. PMID: 32622779 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 1, 2020 Category: Radiology Authors: de Muinck Keizer DM, Kerkmeijer LGW, Willigenburg T, van Lier ALHMW, Hartogh MDD, van der Voort van Zyp JRN, de Groot-van Breugel EN, Raaymakers BW, Lagendijk JJW, de Boer JCJ Tags: Radiother Oncol Source Type: research

Impact of Invasive Nodal Staging on Regional and Distant Recurrence Rates after SBRT for Inoperable Stage I NSCLC.
CONCLUSIONS: In patients with early-stage NSCLC deemed node-negative by PET/CT, addition of INS did not appreciably alter patterns of failure or survival after definitive SBRT. This study does not question the established value of INS for equivocal or suspicious nodes. PMID: 32622780 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 1, 2020 Category: Radiology Authors: Kennedy WR, Samson PP, Gabani P, Nikitas J, Bradley JD, Roach MC, Robinson CG Tags: Radiother Oncol Source Type: research

Magnetic resonance-based synthetic computed tomography images generated using generative adversarial networks for nasopharyngeal carcinoma radiotherapy treatment planning.
CONCLUSION: Both cGAN and cycleGAN could swiftly generate accurate SCT volume images from MR images, with high dosimetric accuracy for NPC IMRT planning. cGAN was preferable if high-quality MR-CT image pairs were available. PMID: 32622781 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 1, 2020 Category: Radiology Authors: Peng Y, Chen S, Qin A, Chen M, Gao X, Liu Y, Miao J, Gu H, Zhao C, Deng X, Qi Z Tags: Radiother Oncol Source Type: research

Involved node radiation therapy in the combined modality treatment for early-stage Hodgkin lymphoma: Analysis of relapse location and long-term outcome.
CONCLUSIONS: Modern treatment with brief chemotherapy and limited radiotherapy provides excellent long-term disease control in ESHL. Neither bulk, high FDG-uptake, nor residual CT abnormality after chemotherapy could predict initially involved lymph nodes with a high risk of relapse. PMID: 32622782 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 1, 2020 Category: Radiology Authors: Nielsen K, Vestmoe Maraldo M, Kiil Berthelsen A, Loft A, de Nully Brown P, Richter Vogelius I, Meidahl Petersen P, Specht L Tags: Radiother Oncol Source Type: research

Letter to the editor regarding "lack of supporting data make the risks of a clinical trial of radiation therapy as a treatment for COVID-19 pneumonia unacceptable".
Letter to the editor regarding "lack of supporting data make the risks of a clinical trial of radiation therapy as a treatment for COVID-19 pneumonia unacceptable". Radiother Oncol. 2020 Jul 01;: Authors: Magrini SM, Katz MS, Tomasini D, Sasso G, Triggiani L, di Monale E Bastia MB, Spiazzi L PMID: 32621829 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 30, 2020 Category: Radiology Authors: Magrini SM, Katz MS, Tomasini D, Sasso G, Triggiani L, di Monale E Bastia MB, Spiazzi L Tags: Radiother Oncol Source Type: research

Prioritization on palliative radiotherapy during the COVID-19 pandemic (and beyond).
PMID: 32621830 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 30, 2020 Category: Radiology Authors: Francesco C, Stefania M, Antonietta GM, Vincenzo V Tags: Radiother Oncol Source Type: research

Letter to the editor regarding wei w et al.: "Experience of the hubei cancer hospital in wuhan, china".
Letter to the editor regarding wei w et al.: "Experience of the hubei cancer hospital in wuhan, china". Radiother Oncol. 2020 Jul 01;: Authors: Merlotti A, Taglianti RV, Melano A, Reali LGA, Petrucci R, Russi EG PMID: 32621831 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 30, 2020 Category: Radiology Authors: Merlotti A, Taglianti RV, Melano A, Reali LGA, Petrucci R, Russi EG Tags: Radiother Oncol Source Type: research

Hypofractionation in COVID-19 Radiotherapy: A Mix of Evidence Based Medicine and of Opportunities.
PMID: 32621832 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 30, 2020 Category: Radiology Authors: Portaluri M, Barba MC, Musio D, Tramacere F, Pati F, Bambace S Tags: Radiother Oncol Source Type: research

Cancer oligometastases heterogeneity: Standardizing nomenclature in regard to defining oligometastatic disease from a radiation oncology perspective: an ESTRO-ASTRO consensus document.
PMID: 32619454 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 29, 2020 Category: Radiology Authors: Boon IS, Yong TPTA, Boon CS Tags: Radiother Oncol Source Type: research

Does ADT benefit unfavourable intermediate risk prostate cancer patients treated with brachytherapy boost and external beam radiotherapy? A propensity-score matched analysis.
CONCLUSION: Short-term ADT increased BFFS in UIR prostate cancer patients treated with HDR-BT boost plus EBRT. PMID: 32619455 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 29, 2020 Category: Radiology Authors: Mendez LC, Martell K, Warner A, Tseng CL, Chung H, Loblaw A, Rodrigues GB, Morton G Tags: Radiother Oncol Source Type: research

Response to "Hypofractionated chemoradiotherapy for locally advanced non-small cell lung cancer: is split-dose chemotherapy safer than full dose chemotherapy?"
Response to "Hypofractionated chemoradiotherapy for locally advanced non-small cell lung cancer: is split-dose chemotherapy safer than full dose chemotherapy?" Radiother Oncol. 2020 Jun 27;: Authors: Kepka L, Socha J PMID: 32603673 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 26, 2020 Category: Radiology Authors: Kepka L, Socha J Tags: Radiother Oncol Source Type: research

Challenges in conducting large randomised control trials of palliative radiotherapy in head and neck cancer.
PMID: 32603674 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 26, 2020 Category: Radiology Authors: Shahid Iqbal M, Kovarik J, Kelly C Tags: Radiother Oncol Source Type: research

Augmenting the therapeutic window of radiotherapy: A perspective on molecularly targeted therapies and nanomaterials.
Abstract Radiation therapy is a cornerstone of modern cancer therapy alongside surgery, chemotherapy, and immunotherapy, with over half of all cancer patients receiving radiation therapy as part of their treatment regimen. Development of novel radiation sensitizers that can improve the therapeutic ratio of radiation are sought after, particularly for tumors at an elevated risk of local and regional recurrence such as locally-advanced lung, head and neck, and gastrointestinal tumors. This review discusses clinical strategies to enhance radiotherapy efficacy and decrease toxicity, hence, increasing the overall thera...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 25, 2020 Category: Radiology Authors: Reda M, Bagley AF, Zaidan HY, Yantasee W Tags: Radiother Oncol Source Type: research

Fibroblast Activation Protein (FAP) specific PET for advanced target volume delineation in Glioblastoma.
g S Abstract Fibroblast Activation Protein (FAP)-specific Positron Emission Tomography (PET) has shown promising results in various cancers. This pilot study compares FAP-specific PET to MRI for treatment planning in 13 Glioblastoma patients. The resulting incongruent volumes could provide additional information for radiotherapy or biopsy planning. PMID: 32598977 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 25, 2020 Category: Radiology Authors: Windisch P, Röhrich M, Regnery S, Tonndorf-Martini E, Held T, Lang K, Bernhardt D, Rieken S, Giesel F, Haberkorn U, Debus J, Adeberg S Tags: Radiother Oncol Source Type: research

Assessing the role of stereotactic body radiation therapy in a large cohort of patients with lymph node oligometastases: does it affect systemic treatment's intensification?
CONCLUSION: With the present analysis, we confirmed on a large cohort the benefit from SBRT on lymph node oligometastases in multidisciplinary management. Combination of SBRT with new systemic therapies, including immunotherapy and targeted therapy, should be investigated to reduce the risk of progression out of the field of irradiation. PMID: 32593644 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 24, 2020 Category: Radiology Authors: Franzese C, Badalamenti M, Comito T, Franceschini D, Clerici E, Navarria P, Loi M, D'agostino G, Baldaccini D, Chiola I, Reggiori G, Mancosu P, Tomatis S, Scorsetti M Tags: Radiother Oncol Source Type: research

Daily computed tomography image guidance: dosimetric advantages outweigh low-dose radiation exposure for treatment of mediastinal lymphoma.
Abstract CT-guided treatment delivery can improve target localization in mediastinal lymphoma patients treated with "butterfly" intensity-modulated radiotherapy and deep-inspiration breath hold. Although daily CT imaging adds additional radiation exposure, its use may be justified given the greater normal tissue sparing enabled by PTV margin reduction. PMID: 32593645 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 24, 2020 Category: Radiology Authors: Zhu LL, Martin RM, Gunther JR, Wong PF, Hancock D, Moreno AC, Dabaja BS, Pinnix CC Tags: Radiother Oncol Source Type: research

Long-term results of a protocol-based ultrasound-guided salvage brachytherapy as re-irradiation for local recurrent prostate cancer.
CONCLUSION: PDR salvage brachytherapy in local recurrent previously irradiated prostate cancer is efficient with low late toxicity. Salvage-brachytherapy represents a valuable therapeutic option for the treatment of previously irradiated locally recurrent prostate cancer. PMID: 32593646 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 24, 2020 Category: Radiology Authors: Schönle N, Strnad V, Lotter M, Kreppner S, Fietkau R Tags: Radiother Oncol Source Type: research

Letter to editor regarding Urban et al., FDG-PET/CT scan assessment of response 12 weeks post radical radiotherapy in oropharynx head and neck cancer: The impact of p16 status.
PMID: 32592891 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 23, 2020 Category: Radiology Authors: Rulach R, Zhou S, Paterson C Tags: Radiother Oncol Source Type: research

Metformin: (future) best friend of the radiation oncologist?
Abstract Several molecules are being investigated for their ability to enhance the anti-tumor effect of radiotherapy. The widely prescribed antidiabetic drug metformin has been suggested to possess anti-cancer activity; data indicate that metformin could also enhance radiation sensitivity. The purpose of this review is to summarize current knowledge on the specific effect of metformin in the field of RT, while also discussing the many unknowns that persist. Preclinical models point to multiple mechanisms involved in the radiosensitizing effects of metformin that are mainly linked to mitochondrial complex I inhibit...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 23, 2020 Category: Radiology Authors: Chevalier B, Pasquier D, Lartigau EF, Chargari C, Schernberg A, Jannin A, Mirabel X, Vantyghem MC, Escande A Tags: Radiother Oncol Source Type: research

BMI1-KLF4 axis deficiency improves responses to neoadjuvant concurrent chemoradiotherapy in patients with rectal cancer.
Abstract PURPOSE: Neoadjuvant concurrent chemoradiotherapy (CCRT) is a gold standard treatment for patients with stage II/III rectal cancer. B-cell-specific Moloney murine leukemia virus insertion site 1 (BMI1) is a member of the polycomb group of proteins that are involved in regulating gene expression. High levels of BMI1 have been demonstrated to contribute to the malignant phenotypes of several cancers; however, its relevance in rectal cancer treated with CCRT is largely unknown. METHODS AND MATERIALS: We used two patient cohorts to address the clinical relevance of BMI1 in human cancers. In addition, HT-...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 23, 2020 Category: Radiology Authors: Hsu YC, Luo CW, Huang WL, Wu CC, Chou CL, Chen CI, Chang SJ, Chai CY, Wang HC, Chen TY, Li CF, Pan MR Tags: Radiother Oncol Source Type: research