Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology RSS feedThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Nodal failure after chemo-radiation and MRI guided brachytherapy in cervical cancer: Patterns of failure in the EMBRACE study cohort.
CONCLUSION: Within the EMBRACE study cohort the overall number of patients developing nodal failure is low, significantly lower for N- compared to N+ patients. Pathological nodes at diagnosis are mainly located in the pelvis, whereas nodal failures are more often reported in the PAO region. About 40% of all nodal failures were reported outside the treatment targets. PMID: 31005214 [PubMed - in process] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 23, 2019 Category: Radiology Authors: Nomden CN, Pötter R, de Leeuw AAC, Tanderup K, Lindegaard JC, Schmid MP, Fortin I, Haie-Meder C, Mahantshetty U, Hoskin P, Segedin B, Bruheim K, Rai B, Huang F, Cooper R, Van Der Steen Banasik E, Van Limbergen E, Jürgenliemk-Schulz IM, EMBRACE Collabora Tags: Radiother Oncol Source Type: research

Pleural contact decreases survival in clinical T1N0M0 lung cancer patients undergoing SBRT.
Abstract BACKGROUND: Clinical staging, as used for patients treated with stereotactic body radiotherapy (SBRT) for early-stage lung cancer, inadequately accounts for pleural invasion, which is a pathologic criteria. Considering the current situation, we analyzed effects of relationships between tumors and the pleura on treatment outcomes of SBRT for early-stage lung cancer. MATERIALS AND METHODS: Among consecutive patients treated with SBRT between 2006 and 2017, we retrospectively identified non-small cell lung cancer patients with primary tumor diameters ≤4 cm and N0M0. The relationships between tumors...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 23, 2019 Category: Radiology Authors: Eriguchi T, Takeda A, Tsurugai Y, Sanuki N, Kibe Y, Hara Y, Kaneko T, Taguri M, Shigematsu N Tags: Radiother Oncol Source Type: research

Long-term results of a multicenter phase II study of preoperative chemoradiotherapy with S-1 plus oxaliplatin for locally advanced rectal cancer (JACCRO CC-04: SHOGUN Trial).
CONCLUSIONS: The study showed a high pCR rate with no severe toxicity, good follow-up results, and good loco-regional control. Therefore, addition of oxaliplatin to preoperative CRT with S-1 in patients with LARC might be feasible and lead to better local control than standard treatment. PMID: 31005216 [PubMed - in process] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 23, 2019 Category: Radiology Authors: Kondo K, Matsusaka S, Ishihara S, Horie H, Uehara K, Oguchi M, Murafushi K, Ueno M, Mizunuma N, Shimbo T, Kato D, Okuda J, Hashiguchi Y, Nakazawa M, Sunami E, Kawai K, Yamashita H, Okada T, Ishikawa Y, Fujii M, Nakajima T Tags: Radiother Oncol Source Type: research

Patient-Reported Sexual Survivorship Following High-Dose Image-Guided Proton Therapy for Prostate Cancer.
CONCLUSIONS: Patient-reported pretreatment sexual function and comorbidities enables stratification and prediction of erectile function. EPIC subset questions with baseline comorbidities may potentially serve as a quick and practical clinical tool for predicting sexual survivorship. PMID: 31005217 [PubMed - in process] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 23, 2019 Category: Radiology Authors: Holtzman AL, Bryant CM, Mendenhall NP, Mendenhall WM, Nichols RC, Henderson RH, Figura N, Morris CG, Williams CR, Li Z, Hoppe BS Tags: Radiother Oncol Source Type: research

Adjuvant radiotherapy for Merkel cell carcinoma: A systematic review and meta-analysis.
Abstract Merkel cell carcinoma (MCC) is a rare and aggressive cutaneous malignancy with a high propensity for local recurrence and regional and distant metastases. The main treatment is surgery with narrow excision margins and draining nodes, plus or minus adjuvant radiotherapy (RT) on the surgical bed and/or lymph nodes. We performed a systematic review and meta-analysis of the benefits of adjuvant RT in MCC treatment. PubMed, EMBASE, and the Cochrane Library were systematically searched to identify relevant studies published before September 2018. Prospective trials and retrospective series comparing adjuvant RT...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 23, 2019 Category: Radiology Authors: Petrelli F, Ghidini A, Torchio M, Prinzi N, Trevisan F, Dallera P, De Stefani A, Russo A, Vitali E, Bruschieri L, Costanzo A, Seghezzi S, Ghidini M, Varricchio A, Cabiddu M, Barni S, de Braud F, Pusceddu S Tags: Radiother Oncol Source Type: research

Can patient-reported outcomes be used instead of clinician-reported outcomes and photographs as primary endpoints of late normal tissue effects in breast radiotherapy trials? Results from the IMPORT LOW trial.
Abstract BACKGROUND: In an era of low local relapse rates after adjuvant breast radiotherapy, risks of late normal-tissue effects (NTE) need to be balanced against risk of relapse. NTE are assessed using patient-reported outcome measures (PROMs), clinician-reported outcomes (CRO) and photographs. This analysis investigates whether PROMs can be used as primary NTE endpoints in breast radiotherapy trials. METHODS: Analyses were conducted within IMPORT LOW (ISRCTN12852634) at 2 and 5 years. NTE were recorded by CRO, photographs and PROMs. Measures of agreement tested concordance, risk ratios for radiotherapy g...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 23, 2019 Category: Radiology Authors: Bhattacharya IS, Haviland JS, Hopwood P, Coles CE, Yarnold JR, Bliss JM, Kirby AM, IMPORT Trialists Tags: Radiother Oncol Source Type: research

Increased distance from a treating proton center is associated with diminished ability to follow patients enrolled on a multicenter radiation oncology registry.
Abstract PURPOSE: Consistent follow-up and data collection are necessary to identify long-term benefits/detriments of proton radiotherapy. Obtaining comprehensive clinical follow-up can be difficult and time-intensive for proton centers. Here we evaluate what factors affect maximum follow-up time among MGH Pediatric Proton Consortium Registry (PPCR) participants. PATIENTS AND METHODS: Enrollment in the PPCR was offered to any patient
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 23, 2019 Category: Radiology Authors: Lawell MP, Bajaj BVM, Gallotto SL, Hess CB, Patteson BE, Nartowicz JA, Giblin MJ, Kleinerman RA, Berrington de Gonzalez A, Ebb DH, Tarbell NJ, MacDonald SM, Weyman EA, Yock TI Tags: Radiother Oncol Source Type: research

Pre-hydration in cisplatin-based CCRT: Effects on tumour concentrations and treatment outcome.
CONCLUSION: Pre-hydration reduces cisplatin tumour concentrations in mice, but it does not compromise treatment outcomes in NSCLC patients treated with daily cisplatin and radiotherapy. PMID: 31005221 [PubMed - in process] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 23, 2019 Category: Radiology Authors: Aalbersberg EA, Rossi MM, de Wit-van der Veen LJ, Walraven I, van den Heuvel MM, Sonke JJ, Belderbos JS, Vogel WV Tags: Radiother Oncol Source Type: research

Subclassification of skull-base invasion for nasopharyngeal carcinoma using cluster, network and survival analyses: A double-center retrospective investigation.
CONCLUSIONS: Different types of SBIs had different effects on the prognosis for NPC. We recommend patients with T3 slight not be defined as T3 but, rather, as T2. PMID: 31005222 [PubMed - in process] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 23, 2019 Category: Radiology Authors: Li HJ, Hu YY, Huang L, Zhou J, Li JJ, Xie CB, Chen MY, Sun Y, Liu LZ, Tian L Tags: Radiother Oncol Source Type: research

Multi-institutional analysis of stereotactic body radiation therapy for operable early-stage non-small cell lung carcinoma.
CONCLUSIONS: Although patients with operable NSCLC experience higher OS than their inoperable counterparts, disease-related outcomes are similar. These results may better inform shared decision-making between medically operable patients and their multidisciplinary providers. PMID: 31005223 [PubMed - in process] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 23, 2019 Category: Radiology Authors: Kann BH, Verma V, Stahl JM, Ross R, Dosoretz AP, Shafman TD, Gross CP, Park HS, Yu JB, Decker RH Tags: Radiother Oncol Source Type: research

Feasibility of stereotactic radiotherapy using a 1.5  T MR-linac: Multi-fraction treatment of pelvic lymph node oligometastases.
Feasibility of stereotactic radiotherapy using a 1.5 T MR-linac: Multi-fraction treatment of pelvic lymph node oligometastases. Radiother Oncol. 2019 May;134:50-54 Authors: Werensteijn-Honingh AM, Kroon PS, Winkel D, Aalbers EM, van Asselen B, Bol GH, Brown KJ, Eppinga WSC, van Es CA, Glitzner M, de Groot-van Breugel EN, Hackett SL, Intven M, Kok JGM, Kontaxis C, Kotte AN, Lagendijk JJW, Philippens MEP, Tijssen RHN, Wolthaus JWH, Woodings SJ, Raaymakers BW, Jürgenliemk-Schulz IM Abstract Online adaptive radiotherapy using the 1.5 Tesla MR-linac is feasible for SBRT (5 × 7 Gy) of pel...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 23, 2019 Category: Radiology Authors: Werensteijn-Honingh AM, Kroon PS, Winkel D, Aalbers EM, van Asselen B, Bol GH, Brown KJ, Eppinga WSC, van Es CA, Glitzner M, de Groot-van Breugel EN, Hackett SL, Intven M, Kok JGM, Kontaxis C, Kotte AN, Lagendijk JJW, Philippens MEP, Tijssen RHN, Wolthaus Tags: Radiother Oncol Source Type: research

Single versus multifraction radiotherapy for spinal cord compression: A systematic review and meta-analysis.
Abstract BACKGROUND: While multifraction radiotherapy (RT) regimens (MFRT) have been considered the standard of care in patients with metastatic epidural spinal cord compression (MESCC) with limited prognosis, recent randomized evidence has demonstrated that single fraction RT (SFRT) may be equivalent in terms of functional and overall outcomes. A systematic review and meta-analysis was conducted to determine the effects of SFRT compared to short course MFRT in patients with MESCC. METHODS: A search of OVID, EMBASE, and the Cochrane Central Register of Controlled Trials from inception to February 2018 was con...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 23, 2019 Category: Radiology Authors: Donovan EK, Sienna J, Mitera G, Kumar-Tyagi N, Parpia S, Swaminath A Tags: Radiother Oncol Source Type: research

Pancreatic cancer treated with SBRT: Effect of anatomical interfraction variations on dose to organs at risk.
CONCLUSIONS: Anatomical interfraction variations increase OAR dose during SBRT for pancreatic cancer daily imaging using integrated CT/CyberKnife may allow to implement strategies to reduce the risk of OAR overirradiation during pancreatic SBRT. PMID: 31005226 [PubMed - in process] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 23, 2019 Category: Radiology Authors: Loi M, Magallon-Baro A, Suker M, van Eijck C, Sharma A, Hoogeman M, Nuyttens J Tags: Radiother Oncol Source Type: research

The addition of cetuximab to preoperative chemoradiotherapy for locally advanced esophageal squamous cell carcinoma is associated with high rate of long term survival: Mature results from a prospective phase Ib/II trial.
Abstract AIM: This phase IB/II study evaluated the safety and efficacy of the addition of cetuximab to standard preoperative chemoradiotherapy (CRT) in locally advanced esophageal cancer (LAEC). METHODS: Patients (pts) with resectable LAEC (T2-3N0-1M0, T1-3N1M0 or T1-3N0-1M1A) received an induction cycle of cisplatin 100 mg/m2, day 1, and 5-fluorouracil (5-FU) 1000 mg/m2/day, days 1-5, followed 4 weeks later by radiotherapy, 50.4 Gy, given with 2 cycles of cisplatin 75 mg/m2 and escalating doses of 5-FU, days 1-4 and 29-32. Pts received 10 weekly infusions of cetuximab, 250 mg/m2, with a loading d...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 23, 2019 Category: Radiology Authors: Brenner B, Purim O, Gordon N, Goshen-Lago T, Idelevich E, Kashtan H, Menasherov N, Fenig E, Sulkes A, Kundel Y Tags: Radiother Oncol Source Type: research

Radiation therapy dose de-escalation compared to standard dose radiation therapy in definitive treatment of HPV-positive oropharyngeal squamous cell carcinoma.
Abstract BACKGROUND: Despite existing evidence that human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) has a favorable prognosis compared to HPV-negative OPSCC, randomized studies have yet to report the effect of de-escalating radiation therapy (RT) dose for definitive treatment. The aim of this study was to assess the effectiveness of dose de-escalated RT (DDRT) vs. standard dose RT (SDRT) in patients with HPV-positive OPSCC. METHODS: This was an observational study using the National Cancer Database (Year 2010-2014) to identify patients who had HPV-positive OPSCC and were trea...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 23, 2019 Category: Radiology Authors: Gabani P, Lin AJ, Barnes J, Oppelt P, Adkins DR, Rich JT, Zevallos JP, Daly MD, Gay HA, Thorstad WL Tags: Radiother Oncol Source Type: research

Treatment patterns and disease outcomes for pediatric patients with refractory or recurrent Hodgkin lymphoma treated with curative-intent salvage radiotherapy.
CONCLUSION: rrHL is responsive to salvage RT, with low LF rates after moderate doses. OS is excellent, despite refractory disease. Initial salvage therapy response predicts subsequent LF. PMID: 31005229 [PubMed - in process] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 23, 2019 Category: Radiology Authors: Tinkle CL, Williams NL, Wu H, Wu J, Kaste SC, Shulkin BL, Talleur AC, Flerlage JE, Hudson MM, Metzger ML, Krasin MJ Tags: Radiother Oncol Source Type: research

Towards optimal stopping in radiation therapy.
Abstract A typical fractionated radiotherapy (RT) course is a long and arduous process, demanding significant financial, physical, and mental commitments from patients. Each additional session of RT significantly increases the physical and psychological burden on patients and leads to higher radiation exposure in organs-at-risk (OAR), while, in some cases, the therapeutic benefits might not be high enough to justify the risks. Today, through technological advancements in molecular biology, imaging, and genetics more information is gathered about individual patient response before, during, and after the treatment. ...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 23, 2019 Category: Radiology Authors: Ajdari A, Niyazi M, Nicolay NH, Thieke C, Jeraj R, Bortfeld T Tags: Radiother Oncol Source Type: research

Corrigendum to "Update of the systematic review of palliative radiation therapy fractionation for bone metastases" [Radiother. Oncol. 126 (2018) 547-557].
Corrigendum to "Update of the systematic review of palliative radiation therapy fractionation for bone metastases" [Radiother. Oncol. 126 (2018) 547-557]. Radiother Oncol. 2019 Apr 10;: Authors: Rich SE, Chow R, Raman S, Liang Zeng K, Lutz S, Lam H, Silva MF, Chow E PMID: 30981439 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 10, 2019 Category: Radiology Authors: Rich SE, Chow R, Raman S, Liang Zeng K, Lutz S, Lam H, Silva MF, Chow E Tags: Radiother Oncol Source Type: research

In response to Komiya T et al. "Addition of chemotherapy improves overall survival in patients with T2N0M0 non-small cell lung cancer undergoing definitive radiation therapy: An analysis of the SEER database".
In response to Komiya T et al. "Addition of chemotherapy improves overall survival in patients with T2N0M0 non-small cell lung cancer undergoing definitive radiation therapy: An analysis of the SEER database". Radiother Oncol. 2019 Apr 10;: Authors: Hsia TC, Tu CY, Li CC, Chien CR PMID: 30981440 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 10, 2019 Category: Radiology Authors: Hsia TC, Tu CY, Li CC, Chien CR Tags: Radiother Oncol Source Type: research

Response to Adomas Bunevicius.
Authors: PMID: 30961894 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 5, 2019 Category: Radiology Tags: Radiother Oncol Source Type: research

Dose escalation by intensity modulated radiotherapy in liver-directed concurrent chemoradiotherapy for locally advanced BCLC stage C hepatocellular carcinoma.
Abstract PURPOSE: To evaluate the effects of dose escalation by intensity-modulated radiotherapy (IMRT) in liver-directed concurrent chemoradiotherapy for locally advanced Barcelona Clinic Liver Cancer stage C hepatocellular carcinoma (BCLC-C HCC). MATERIALS AND METHODS: During 2005-2016, 637 patients with BCLC-C HCC received RT with concurrent hepatic arterial 5-fluorouracil. Patients were divided into two groups according to the biologically effective doses for a tumor (α/β = 10 Gy):
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 1, 2019 Category: Radiology Authors: Byun HK, Kim HJ, Im YR, Kim DY, Han KH, Seong J Tags: Radiother Oncol Source Type: research

Applying a commercial atlas-based synthetic Computed Tomography algorithm to patients with hip prostheses for prostate Magnetic Resonance-only radiotherapy.
This study aimed to investigate the dosimetric accuracy of applying a commercial sCT algorithm, based on an atlas of patients without hip prostheses, to patients with prostheses. MATERIALS AND METHODS: 18 patients with unilateral hip prostheses received MR and CT scans in the radiotherapy position. sCTs were generated from the MR using a commercial algorithm. The clinical Volumetric Modulated Arc Therapy (VMAT) plan, consisting of partial arcs which avoided the prosthesis, was recalculated using the sCT and the dose distribution compared. RESULTS: The mean isocentre dose difference was ΔD = (-0.4 &plu...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 1, 2019 Category: Radiology Authors: Wyatt J, McCallum H Tags: Radiother Oncol Source Type: research

Predicting radiation pneumonitis in locally advanced stage II-III non-small cell lung cancer using machine learning.
CONCLUSIONS: We highlight Random Forest as an accurate machine learning method to identify known and new predictors of symptomatic RP. Furthermore, this analysis confirms the importance of lung V20, lung mean and pack-year as predictors of RP while also introducing esophagus max as an important RP predictor. PMID: 30935565 [PubMed - in process] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 1, 2019 Category: Radiology Authors: Luna JM, Chao HH, Diffenderfer ES, Valdes G, Chinniah C, Ma G, Cengel KA, Solberg TD, Berman AT, Simone CB Tags: Radiother Oncol Source Type: research

The METABANK score: A clinical tool to predict survival after stereotactic radiotherapy for oligometastatic disease.
der M Abstract BACKGROUND AND PURPOSE: Stereotactic radiotherapy (SRT, SBRT) is widely used in oligometastatic cancer, but the heterogeneity of the population complicates estimation of the prognosis. We investigated the role of different clinical and inflammatory parameters. MATERIALS AND METHODS: We included all patients treated with SRT for 1-5 oligometastases between 2003 and 2017 in our center. Patients were randomized between a model training set (2/3) and a separate validation set (1/3). A Cox regression model was built, validated and risk points were attributed to the resulting parameters. RESULTS...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 1, 2019 Category: Radiology Authors: Van den Begin R, Engels B, Collen C, de Vin T, Defauw A, Dubaere E, Barbé K, De Ridder M Tags: Radiother Oncol Source Type: research

Intrinsic and extrinsic tumor characteristics are of minor relevance for the efficacy of split-dose carbon ion irradiation in three experimental prostate tumors.
CONCLUSION: The response to carbon ion irradiations is much less dependent on biological differences between and within the tumor-sublines. Tumors showing a high resistance against photon treatments, also exhibit the largest RBE for carbon ions. Carbon ions could therefore be of clinical advantage for the treatment of tumors with known resistance factors against photons. PMID: 30935567 [PubMed - in process] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 1, 2019 Category: Radiology Authors: Glowa C, Peschke P, Brons S, Debus J, Karger CP Tags: Radiother Oncol Source Type: research

Significance of perineural and lymphovascular invasion in locally advanced rectal cancer treated by preoperative chemoradiotherapy and radical surgery: Can perineural invasion be an indication of adjuvant chemotherapy?
Abstract PURPOSE: To investigate the prognostic significance of lymphovascular space invasion (LVI) and perineural invasion (PNI) in rectal cancer. METHODS AND MATERIALS: Clinical data of 1,232 stage II-III rectal cancer patients from six tertiary institutions were analyzed. All patients were treated by long-course preoperative chemoradiotherapy (CRT) followed by total mesorectal excision (TME). Adjuvant systemic chemotherapy was performed for 962 (78.1%) patients according to the multidisciplinary team's decision. Treatment outcomes and prognostic factors were evaluated according to the lymphovascular invasi...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 1, 2019 Category: Radiology Authors: Song JH, Yu M, Kang KM, Lee JH, Kim SH, Nam TK, Jeong JU, Jang HS, Lee JW, Jung JH Tags: Radiother Oncol Source Type: research

Mechanically-assisted non-invasive ventilation: A step forward to modulate and to improve the reproducibility of breathing-related motion in radiation therapy.
Abstract BACKGROUND AND PURPOSE: When using highly conformal radiotherapy techniques, a stabilized breathing pattern could greatly benefit the treatment of mobile tumours. Therefore, we assessed the feasibility of Mechanically-assisted non-invasive ventilation (MANIV) on unsedated volunteers, and its ability to stabilize and modulate the breathing pattern over time. MATERIALS AND METHODS: Twelve healthy volunteers underwent 2 sessions of dynamic MRI under 4 ventilation modes: spontaneous breathing (SP), volume-controlled mode (VC) that imposes regular breathing in physiologic conditions, shallow-controlled mo...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 1, 2019 Category: Radiology Authors: Van Ooteghem G, Dasnoy-Sumell D, Lambrecht M, Reychler G, Liistro G, Sterpin E, Geets X Tags: Radiother Oncol Source Type: research

Are further studies needed to justify the use of proton therapy for paediatric cancers of the central nervous system? A review of current evidence.
Abstract Clinical implementation of proton therapy demonstrated its potential to overcome some limitations of the more traditional, photon-based radiotherapy, due to physical and radiobiological advantages of protons. However, questions concerning the long-term effects of protons on paediatric patients need outcome analysis of the reported literature in order to be answered. The current paper has analysed the available clinical trials and comparative studies (protons vs photons) for paediatric cancers of the central nervous system (CNS) analysing the reported outcomes and follow-up times in order to evaluate the s...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 1, 2019 Category: Radiology Authors: Huynh M, Marcu LG, Giles E, Short M, Matthews D, Bezak E Tags: Radiother Oncol Source Type: research

Importance of training in external beam treatment planning for locally advanced cervix cancer: Report from the EMBRACE II dummy run.
CONCLUSION: A dummy-run as applied in EMBRACE II, consisting of training and examination cases enabled us to test institutes' treatment planning capabilities, and improve plan quality. PMID: 30935571 [PubMed - in process] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 1, 2019 Category: Radiology Authors: Seppenwoolde Y, Assenholt MS, Georg D, Nout R, Tan LT, Rumpold T, de Leeuw A, Jürgenliemk-Schulz I, Kirisits C, Pötter R, Lindegaard JC, Tanderup K, EMBRACE Collaborative Group Tags: Radiother Oncol Source Type: research

Feasibility and accuracy of quantitative imaging on a 1.5 T MR-linear accelerator.
CONCLUSION: These results indicate that qMRI on the Unity MR-linac is feasible, accurate, and repeatable which is promising for treatment response monitoring and treatment plan adaptation based on daily qMRI. PMID: 30935572 [PubMed - in process] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 1, 2019 Category: Radiology Authors: Kooreman ES, van Houdt PJ, Nowee ME, van Pelt VWJ, Tijssen RHN, Paulson ES, Gurney-Champion OJ, Wang J, Koetsveld F, van Buuren LD, Ter Beek LC, van der Heide UA Tags: Radiother Oncol Source Type: research

Reoxygenation during radiotherapy in intermediate-risk prostate cancer.
kis D Abstract Hypoxia is a major risk factor of prostate cancer radioresistance. We evaluated hypoxia non-invasively, using 18F-Misonidazole PET/CT prior to radiotherapy and after a dose of 20 Gy in intermediate-risk prostate cancer patients. Decreased hypoxic volumes were observed in all patients, suggesting that radiotherapy induces early prostate tumor reoxygenation. PMID: 30935573 [PubMed - in process] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 1, 2019 Category: Radiology Authors: Supiot S, Rousseau C, Dore M, Chèze-Le-Rest C, Kandel-Aznar C, Potiron V, Guerif S, Paris F, Ferrer L, Campion L, Meingan P, Delpon G, Hatt M, Visvikis D Tags: Radiother Oncol Source Type: research

Prophylactic cranial irradiation in stage IV small cell lung cancer: Selection of patients amongst European IASLC and ESTRO experts.
CONCLUSION: European radiation and medical oncologists specializing in lung cancer recommend PCI in selected patients and restrict its use primarily to fit, non-elderly patients who responded to chemotherapy. PMID: 30935574 [PubMed - in process] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 1, 2019 Category: Radiology Authors: Putora PM, Glatzer M, Belderbos J, Besse B, Blackhall F, Califano R, Cappuzzo F, de Marinis F, Dziadziuszko R, Felip E, Faivre-Finn C, Früh M, Garrido P, Le Pechoux C, McDonald F, Nestle U, Novello S, O'Brien M, Paz Ares L, Peeters S, Pöttgen C, Ramella Tags: Radiother Oncol Source Type: research

Carotid stenosis prevalence after radiotherapy in nasopharyngeal carcinoma: A meta-analysis.
Abstract PURPOSE: Radiotherapy (RT) is the most effective treatment for nasopharyngeal carcinoma (NPC) but may cause stenosis of the carotid arteries. This meta-analysis evaluates the prevalence of carotid stenosis after radiation therapy. MATERIALS AND METHODS: Online search for studies reporting carotid stenosis in patients with NPC who received radiation therapy (RT) compared to NPC patients who did not receive RT and compared to healthy controls. RESULTS: Twelve studies were included for a total analysis of 1928 patients (837 received RT and 1091 were controls). RT patients showed a statistically sig...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 1, 2019 Category: Radiology Authors: Liao W, Zheng Y, Bi S, Zhang B, Xiong Y, Li Y, Fang W, Xiao S, Yang L, Thea A, Liu J Tags: Radiother Oncol Source Type: research

Predictive factors for response and toxicity after brachytherapy for rectal cancer; results from the HERBERT study.
CONCLUSION: Tumor volume is the most important predictive factor for tumor response and a higher dose to the brachytherapy CTV increases the risk of severe clinically and endoscopically observed proctitis after definitive radiotherapy in elderly patients with rectal cancer. PMID: 30935576 [PubMed - in process] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 1, 2019 Category: Radiology Authors: Rijkmans EC, Marijnen CAM, van Triest B, Ketelaars M, Cats A, Inderson A, van den Ende RPJ, Laman MS, Kerkhof EM, Nout RA Tags: Radiother Oncol Source Type: research

A systematic review and meta-analysis of pT2 rectal cancer spread and recurrence pattern: Implications for target design in radiation therapy for organ preservation.
CONCLUSION: This meta-analysis suggests a smaller CTV for cT2 tumours than the current guidelines designed for advanced cancers. PMID: 30935577 [PubMed - in process] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 1, 2019 Category: Radiology Authors: Socha J, Pietrzak L, Zawadzka A, Paciorkiewicz A, Krupa A, Bujko K Tags: Radiother Oncol Source Type: research

Utility of fiducial markers for target positioning in proton radiotherapy of oesophageal carcinoma.
CONCLUSION: Implanted helical gold fiducial markers are a safe and reliable method of providing target-centric positioning verification in proton beam therapy of oesophageal carcinoma. PMID: 30935578 [PubMed - in process] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 1, 2019 Category: Radiology Authors: Apolle R, Brückner S, Frosch S, Rehm M, Thiele J, Valentini C, Lohaus F, Babatz J, Aust DE, Hampe J, Troost EGC Tags: Radiother Oncol Source Type: research

Fatigue following radiation therapy in nasopharyngeal cancer survivors: A dosimetric analysis incorporating patient report and observer rating.
Abstract PURPOSE: To explore for fatigue-related regions and the radiotherapy (RT) dose-fatigue relationship in nasopharyngeal cancer (NPC) survivors. METHODS: Eighty disease-free NPC survivors completed the MD Anderson Symptom Inventory-Head and Neck module (MDASI-HN) after RT. Fatigue was evaluated by the MDASI-HN fatigue item (MDASI-HN-F) and Common Terminology Criteria for Adverse Events v3.0 (CTC-AE), between 6 and 36 months after RT to determine the presence of chronic fatigue. Skull base MRIs and planning CT/RT dose were retrievable for 56 patients. Dosimetric data were extracted for 10 MRI-defined p...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 1, 2019 Category: Radiology Authors: MD Anderson Head Neck Cancer Symptom Working Group Tags: Radiother Oncol Source Type: research

Volume not number of metastases: Gamma Knife radiosurgery management of intracranial lesions from an Australian perspective.
CONCLUSION: Results from the first Gamma Knife radiosurgery center in Australia showed that the treatment is feasible and effective, consistent with the international experience. For patients with larger numbers of intracranial metastases, the total volume of the intracranial burden may be of more significance in predicting outcomes. While there appeared to be a difference in survival by histologic origin, this could be related to concurrent systemic immunotherapy available for certain tumors. PMID: 30935580 [PubMed - in process] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 1, 2019 Category: Radiology Authors: Izard MA, Moutrie V, Rogers JM, Beath K, Grace M, Karle B, Ho A, Fuller JW Tags: Radiother Oncol Source Type: research

Adjuvant radiation therapy for T4 non-rectal colon adenocarcinoma provides a cause-specific survival advantage: A SEER database analysis.
CONCLUSIONS: Adjuvant RT is not routinely utilized for definitive treatment of T4 non-rectal colon cancer, but this analysis shows a significant cause-specific survival benefit. PMID: 30935581 [PubMed - in process] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 1, 2019 Category: Radiology Authors: McLaughlin C, Kim NK, Bandyopadhyay D, Deng X, Kaplan B, Matin K, Fields EC Tags: Radiother Oncol Source Type: research

Proton beam therapy outcomes for localized unresectable hepatocellular carcinoma.
This study documents the utilization and efficacy of proton beam therapy (PBT) in western patients with localized unresectable hepatocellular carcinoma (HCC). METHODS AND METHODS: Forty-six patients with HCC, Child-Pugh class of A or B, no prior radiotherapy history, and ECOG performance status 0-2 received PBT at our institution from 2007 to 2016. Radiographic control within the PBT field (local control, LC) and overall survival (OS) were calculated from the start of PBT. RESULTS: Most (83%) patients had Child-Pugh class A. Median tumor size was 6 cm (range, 1.5-21.0 cm); 22% of patients had multiple tumors ...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 1, 2019 Category: Radiology Authors: Chadha AS, Gunther JR, Hsieh CE, Aliru M, Mahadevan LS, Venkatesulu BP, Crane CH, Das P, Herman JM, Koay EJ, Taniguchi C, Holliday EB, Minsky BD, Suh Y, Park P, Sawakuchi G, Beddar S, Odisio BC, Gupta S, Loyer E, Kaur H, Raghav K, Javle MM, Kaseb AO, Kris Tags: Radiother Oncol Source Type: research

Impact of a dominant intraprostatic lesion (DIL) boost defined by sextant biopsy in permanent I-125 prostate implants on biochemical disease free survival (bDFS) and toxicity outcomes.
CONCLUSIONS: Boost to DIL defined by sextant biopsy with permanent seed prostate implant shows a trend toward improvement of biochemical control in intermediate risk prostate cancer patient without increasing toxicity. PMID: 30935583 [PubMed - in process] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 1, 2019 Category: Radiology Authors: Guimond E, Lavallée MC, Foster W, Vigneault É, Guay K, Martin AG Tags: Radiother Oncol Source Type: research

Ductal carcinoma in situ and intraoperative partial breast irradiation: Who are the best candidates? Long-term outcome of a single institution series.
BA Abstract AIMS: To report the long-term outcome of a single institution series of pure ductal carcinoma in situ (DCIS) treated with accelerated partial irradiation using intraoperative electrons (IOERT). METHODS: From 2000 to 2010, 180 DCIS patients, treated with quadrantectomy and 21 Gy IOERT, were analyzed in terms of ipsilateral breast recurrences (IBRs) and survival outcomes by stratification in two subgroups. The low-risk group included patients who fulfilled the suitable definition according to American Society of Radiation Oncology (ASTRO) Guidelines (size ≤2.5 cm, grade 1-2 and surgical marg...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 1, 2019 Category: Radiology Authors: Leonardi MC, Corrao G, Frassoni S, Vingiani A, Dicuonzo S, Lazzeroni M, Fodor C, Morra A, Gerardi MA, Rojas DP, Dell'Acqua V, Marvaso G, Bassi FD, Galimberti VE, Veronesi P, Miglietta E, Cattani F, Zurrida S, Bagnardi V, Viale G, Orecchia R, Jereczek-Foss Tags: Radiother Oncol Source Type: research

DNA damage response of clinical carbon ion versus photon radiation in human glioblastoma cells.
CONCLUSION: Carbon ions induced more severe DSB damage than photons, which was repaired less efficiently in both cell lines. Thus, carbon ion radiotherapy may help to overcome resistance mechanisms of glioblastoma associated with DNA repair for example in combination with repair pathway-specific drugs in the context of personalized radiotherapy. PMID: 30935585 [PubMed - in process] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 1, 2019 Category: Radiology Authors: Lopez Perez R, Nicolay NH, Wolf JC, Frister M, Schmezer P, Weber KJ, Huber PE Tags: Radiother Oncol Source Type: research

Dosimetric predictors for postoperative pulmonary complications in esophageal cancer following neoadjuvant chemoradiotherapy and surgery.
This study is carried out to identify the most reliable dosimetric predictors for pulmonary complications following NACRT and surgery for esophageal cancer. MATERIALS AND METHODS: We retrospectively reviewed the medical records of 308 patients with esophageal cancer who received surgery following NACRT for locally advanced esophageal cancer from January 2005 to June 2017. Dose-volume histograms (DVH) of both lungs were computed for each patient along with total lung volume, mean lung dose (MLD), V5, V10, V20, and V30. The effect of each parameter on postoperative pulmonary complications was estimated in univariate and...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 1, 2019 Category: Radiology Authors: Cho WK, Oh D, Kim HK, Ahn YC, Noh JM, Shim YM, Zo JI, Choi YS, Sun JM, Lee SH, Ahn MJ, Park K, Nam H Tags: Radiother Oncol Source Type: research

The relationship of lymphocyte recovery and prognosis of esophageal cancer patients with severe radiation-induced lymphopenia after chemoradiation therapy.
CONCLUSION: Lymphocyte count recovery after CRT does not alter the poor long-term outcomes brought about by high-grade lymphopenia during CRT. PMID: 30935587 [PubMed - in process] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 1, 2019 Category: Radiology Authors: Deng W, Xu C, Liu A, van Rossum PSN, Deng W, Liao Z, Koong AC, Mohan R, Lin SH Tags: Radiother Oncol Source Type: research

Synchrotron microbeam radiotherapy evokes a different early tumor immunomodulatory response to conventional radiotherapy in EMT6.5 mammary tumors.
CONCLUSION: Our data are the first to demonstrate substantial differences in macrophage, neutrophil and T cell numbers in tumors following MRT versus CRT, providing support for the concept that MRT evokes a different immunomodulatory response in tumors compared to CRT. PMID: 30935588 [PubMed - in process] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 1, 2019 Category: Radiology Authors: Yang Y, Swierczak A, Ibahim M, Paiva P, Cann L, Stevenson AW, Crosbie JC, Anderson RL, Rogers PAW Tags: Radiother Oncol Source Type: research

A prospective, three-arm, randomized trial of EGCG for preventing radiation-induced esophagitis in lung cancer patients receiving radiotherapy.
CONCLUSION: The application of EGCG could effectively alleviate acute radiation esophagitis in advanced lung cancer without obvious side effects. Prophylactic application of EGCG had a slight advantage over therapeutic use in treatment of acute esophagitis. PMID: 30898322 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 19, 2019 Category: Radiology Authors: Zhao H, Jia L, Chen G, Li X, Meng X, Zhao X, Xing L, Zhu W Tags: Radiother Oncol Source Type: research

Biological effects in normal cells exposed to FLASH dose rate protons.
CONCLUSIONS: In normal lung fibroblasts proton dose rate had little impact on acute effects, but significantly influenced the expression of long-term biological responses in vitro. Compared to conventional dose rates, protons delivered at FLASH dose rates mitigated such delayed detrimental effects. PMID: 30850209 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 5, 2019 Category: Radiology Authors: Buonanno M, Grilj V, Brenner DJ Tags: Radiother Oncol Source Type: research

Re-irradiation of locally recurrent pediatric intracranial ependymoma: Experience of the French society of children's cancer.
CONCLUSION: Local recurrence of brain ependymoma can be treated with full-dose re-irradiation, which can be hypofractionated with an acceptable short term toxicity in spite of high total doses delivered to OARs, especially brain stem. PMID: 30825956 [PubMed - in process] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 1, 2019 Category: Radiology Authors: Régnier E, Laprie A, Ducassou A, Bolle S, Supiot S, Muracciole X, Claude L, Chapet S, Coche-Dequéant B, Vigneron C, Leseur J, Bondiau PY, Habrand JL, Bernier V Tags: Radiother Oncol Source Type: research

Quantitative analysis of diffusion weighted imaging to predict pathological good response to neoadjuvant chemoradiation for locally advanced rectal cancer.
CONCLUSION: Combination of quantitative DWI analysis and clinical characteristics holds great potential in identifying the pGR patients and providing decision support for organ-preserving strategies after nCRT treatment. PMID: 30825957 [PubMed - in process] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 1, 2019 Category: Radiology Authors: Tang Z, Zhang XY, Liu Z, Li XT, Shi YJ, Wang S, Fang M, Shen C, Dong E, Sun YS, Tian J Tags: Radiother Oncol Source Type: research