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Prognostic value of different radiation-related cell death genes in patients with lung adenocarcinoma
CONCLUSION: The multi -gene risk scoring model based on apoptosis might predict radiotherapy benefits of LUAD patients and for those radioresistant patients classified by the model we also provided effective adjuvant chemicals, which would be used to guide clinical treatment.PMID:38548112 | DOI:10.1016/j.radonc.2024.110259 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 28, 2024 Category: Radiology Authors: Cheng Zhou Tianpeng Yang Haibin Chen Jiawen Xu Jiao Liu Xuanyi Liu Shumei Ma Xiaodong Liu Source Type: research

Histology-driven hypofractionated radiation therapy schemes for early-stage lung adenocarcinoma and squamous cell carcinoma
CONCLUSION: We presented the first determination of histology-dependent radiobiological parameters and model-independent histology-driven optimal SBRT and hypofractionated radiation therapy schemes for early-stage lung ADC and SCC. SCC requires substantially higher radiation doses to maximize tumor control than ADC, plausibly attributed to tumor genetic diversity and microenvironment. The determined optimal SBRT schemes agree well with clinical practice for early-stage lung ADC. These proposed optimal fractionation schemes provide first insights for histology-based personalized radiotherapy of two predominant early-stage N...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 28, 2024 Category: Radiology Authors: Feng Liu Michael K Farris James D Ververs Ryan T Hughes Michael T Munley Source Type: research

Assessment of minimum target dose as a predictor of local failure after spine SBRT
CONCLUSIONS: Spine SBRT offers favorable local control; however, minimum dose to the GTV has a strong association with local control. Achieving GTV minimum dose of 14-15.3 Gy with single fraction SBRT is recommended whenever possible.PMID:38548114 | DOI:10.1016/j.radonc.2024.110260 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 28, 2024 Category: Radiology Authors: Roman O Kowalchuk Trey C Mullikin Grant M Spears Benjamin A Johnson-Tesch Peter S Rose Brittany L Siontis Dong Kun Kim Brian A Costello Jonathan M Morris Robert W Gao Satomi Shiraishi John J Lucido Kenneth R Olivier Dawn Owen Bradley J Stish Mark R Waddle Source Type: research

Synergizing the interaction of single nucleotide polymorphisms with dosiomics features to build a dual-omics model for the prediction of radiation pneumonitis
CONCLUSIONS: A novel dual-omics model by synergizing the SNP epistasis effect with dosiomics features was developed. The enhanced the RP prediction suggested its promising clinical utility in identifying the patients with severe RP during thoracic radiotherapy.PMID:38548115 | DOI:10.1016/j.radonc.2024.110261 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 28, 2024 Category: Radiology Authors: Bin Liang Xiaotong Lu Lipin Liu Jianrong Dai Nan Bi Luhua Wang Source Type: research

Prognostic value of different radiation-related cell death genes in patients with lung adenocarcinoma
CONCLUSION: The multi -gene risk scoring model based on apoptosis might predict radiotherapy benefits of LUAD patients and for those radioresistant patients classified by the model we also provided effective adjuvant chemicals, which would be used to guide clinical treatment.PMID:38548112 | DOI:10.1016/j.radonc.2024.110259 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 28, 2024 Category: Radiology Authors: Cheng Zhou Tianpeng Yang Haibin Chen Jiawen Xu Jiao Liu Xuanyi Liu Shumei Ma Xiaodong Liu Source Type: research

Histology-driven hypofractionated radiation therapy schemes for early-stage lung adenocarcinoma and squamous cell carcinoma
CONCLUSION: We presented the first determination of histology-dependent radiobiological parameters and model-independent histology-driven optimal SBRT and hypofractionated radiation therapy schemes for early-stage lung ADC and SCC. SCC requires substantially higher radiation doses to maximize tumor control than ADC, plausibly attributed to tumor genetic diversity and microenvironment. The determined optimal SBRT schemes agree well with clinical practice for early-stage lung ADC. These proposed optimal fractionation schemes provide first insights for histology-based personalized radiotherapy of two predominant early-stage N...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 28, 2024 Category: Radiology Authors: Feng Liu Michael K Farris James D Ververs Ryan T Hughes Michael T Munley Source Type: research

Assessment of minimum target dose as a predictor of local failure after spine SBRT
CONCLUSIONS: Spine SBRT offers favorable local control; however, minimum dose to the GTV has a strong association with local control. Achieving GTV minimum dose of 14-15.3 Gy with single fraction SBRT is recommended whenever possible.PMID:38548114 | DOI:10.1016/j.radonc.2024.110260 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 28, 2024 Category: Radiology Authors: Roman O Kowalchuk Trey C Mullikin Grant M Spears Benjamin A Johnson-Tesch Peter S Rose Brittany L Siontis Dong Kun Kim Brian A Costello Jonathan M Morris Robert W Gao Satomi Shiraishi John J Lucido Kenneth R Olivier Dawn Owen Bradley J Stish Mark R Waddle Source Type: research

Synergizing the interaction of single nucleotide polymorphisms with dosiomics features to build a dual-omics model for the prediction of radiation pneumonitis
CONCLUSIONS: A novel dual-omics model by synergizing the SNP epistasis effect with dosiomics features was developed. The enhanced the RP prediction suggested its promising clinical utility in identifying the patients with severe RP during thoracic radiotherapy.PMID:38548115 | DOI:10.1016/j.radonc.2024.110261 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 28, 2024 Category: Radiology Authors: Bin Liang Xiaotong Lu Lipin Liu Jianrong Dai Nan Bi Luhua Wang Source Type: research

Response to the letter by Boon and colleagues
Radiother Oncol. 2024 Mar 25:110233. doi: 10.1016/j.radonc.2024.110233. Online ahead of print.NO ABSTRACTPMID:38537679 | DOI:10.1016/j.radonc.2024.110233 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 27, 2024 Category: Radiology Authors: J Friborg K Jensen C Grau C R Hansen Source Type: research

Dosimetric parameters predict radiation-induced temporal lobe necrosis in nasopharyngeal carcinoma patients: A systematic review and meta-analysis
In conclusion, this systematic review highlights the significance of dosimetric parameters, particularly Dmax and D1cc, in predicting TLN risk in NPC patients undergoing 3D-CRT, IMRT, and VMAT. The findings provide valuable insights that can help in developing optimal treatment planning strategies and contribute to the development of clinical guidelines in this field.PMID:38537680 | DOI:10.1016/j.radonc.2024.110258 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 27, 2024 Category: Radiology Authors: Jun Dong Wai Tong Ng Charlene H L Wong Ji-Shi Li Heleen Bollen James C H Chow Avraham Eisbruch Anne W M Lee Victor H F Lee Sweet Ping Ng Sandra Nuyts Robert Smee Alfio Ferlito Source Type: research

Response to the letter by Boon and colleagues
Radiother Oncol. 2024 Mar 25:110233. doi: 10.1016/j.radonc.2024.110233. Online ahead of print.NO ABSTRACTPMID:38537679 | DOI:10.1016/j.radonc.2024.110233 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 27, 2024 Category: Radiology Authors: J Friborg K Jensen C Grau C R Hansen Source Type: research

Dosimetric parameters predict radiation-induced temporal lobe necrosis in nasopharyngeal carcinoma patients: A systematic review and meta-analysis
In conclusion, this systematic review highlights the significance of dosimetric parameters, particularly Dmax and D1cc, in predicting TLN risk in NPC patients undergoing 3D-CRT, IMRT, and VMAT. The findings provide valuable insights that can help in developing optimal treatment planning strategies and contribute to the development of clinical guidelines in this field.PMID:38537680 | DOI:10.1016/j.radonc.2024.110258 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 27, 2024 Category: Radiology Authors: Jun Dong Wai Tong Ng Charlene H L Wong Ji-Shi Li Heleen Bollen James C H Chow Avraham Eisbruch Anne W M Lee Victor H F Lee Sweet Ping Ng Sandra Nuyts Robert Smee Alfio Ferlito Source Type: research

Infrared microspectroscopy to elucidate the underlying biomolecular mechanisms of FLASH radiotherapy
CONCLUSION: This work provided new insights into the biomolecular effects involved in FLASH-RT through FTIRM. Our results showed that beyond nucleic acid investigations, one should take into account other dose-rate responsive molecules such as proteins, as they might be key to understand FLASH effect.PMID:38527626 | DOI:10.1016/j.radonc.2024.110238 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 25, 2024 Category: Radiology Authors: Immaculada Mart ínez-Rovira Pierre Montay-Gruel Beno ît Petit Ron Leavitt Roberto Gonz ález-Vegas Pascal Froidevaux Marjorie Juchaux Yolanda Prezado Ibraheem Yousef Marie-Catherine Vozenin Source Type: research

Comment on: Meta-analysis of 5-day preoperative radiotherapy for soft tissue sarcoma (5D-PREORTS)
Radiother Oncol. 2024 Mar 23:110254. doi: 10.1016/j.radonc.2024.110254. Online ahead of print.NO ABSTRACTPMID:38527627 | DOI:10.1016/j.radonc.2024.110254 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 25, 2024 Category: Radiology Authors: Hua-Qing Niu Bo-Yv Zheng Ming-Xiang Zou Tao-Lan Zhang Bo-Wen Zheng Source Type: research

Infrared microspectroscopy to elucidate the underlying biomolecular mechanisms of FLASH radiotherapy
CONCLUSION: This work provided new insights into the biomolecular effects involved in FLASH-RT through FTIRM. Our results showed that beyond nucleic acid investigations, one should take into account other dose-rate responsive molecules such as proteins, as they might be key to understand FLASH effect.PMID:38527626 | DOI:10.1016/j.radonc.2024.110238 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 25, 2024 Category: Radiology Authors: Immaculada Mart ínez-Rovira Pierre Montay-Gruel Beno ît Petit Ron Leavitt Roberto Gonz ález-Vegas Pascal Froidevaux Marjorie Juchaux Yolanda Prezado Ibraheem Yousef Marie-Catherine Vozenin Source Type: research