Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology RSS feedThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Carotid stenosis prevalence after radiotherapy in nasopharyngeal carcinoma: A meta-analysis.
Abstract PURPOSE: Radiotherapy (RT) is the most effective treatment for nasopharyngeal carcinoma (NPC) but may cause stenosis of the carotid arteries. This meta-analysis evaluates the prevalence of carotid stenosis after radiation therapy. MATERIALS AND METHODS: Online search for studies reporting carotid stenosis in patients with NPC who received radiation therapy (RT) compared to NPC patients who did not receive RT and compared to healthy controls. RESULTS: Twelve studies were included for a total analysis of 1928 patients (837 received RT and 1091 were controls). RT patients showed a statistically sig...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 1, 2019 Category: Radiology Authors: Liao W, Zheng Y, Bi S, Zhang B, Xiong Y, Li Y, Fang W, Xiao S, Yang L, Thea A, Liu J Tags: Radiother Oncol Source Type: research

Predictive factors for response and toxicity after brachytherapy for rectal cancer; results from the HERBERT study.
CONCLUSION: Tumor volume is the most important predictive factor for tumor response and a higher dose to the brachytherapy CTV increases the risk of severe clinically and endoscopically observed proctitis after definitive radiotherapy in elderly patients with rectal cancer. PMID: 30935576 [PubMed - in process] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 1, 2019 Category: Radiology Authors: Rijkmans EC, Marijnen CAM, van Triest B, Ketelaars M, Cats A, Inderson A, van den Ende RPJ, Laman MS, Kerkhof EM, Nout RA Tags: Radiother Oncol Source Type: research

A systematic review and meta-analysis of pT2 rectal cancer spread and recurrence pattern: Implications for target design in radiation therapy for organ preservation.
CONCLUSION: This meta-analysis suggests a smaller CTV for cT2 tumours than the current guidelines designed for advanced cancers. PMID: 30935577 [PubMed - in process] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 1, 2019 Category: Radiology Authors: Socha J, Pietrzak L, Zawadzka A, Paciorkiewicz A, Krupa A, Bujko K Tags: Radiother Oncol Source Type: research

Utility of fiducial markers for target positioning in proton radiotherapy of oesophageal carcinoma.
CONCLUSION: Implanted helical gold fiducial markers are a safe and reliable method of providing target-centric positioning verification in proton beam therapy of oesophageal carcinoma. PMID: 30935578 [PubMed - in process] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 1, 2019 Category: Radiology Authors: Apolle R, Brückner S, Frosch S, Rehm M, Thiele J, Valentini C, Lohaus F, Babatz J, Aust DE, Hampe J, Troost EGC Tags: Radiother Oncol Source Type: research

Fatigue following radiation therapy in nasopharyngeal cancer survivors: A dosimetric analysis incorporating patient report and observer rating.
Abstract PURPOSE: To explore for fatigue-related regions and the radiotherapy (RT) dose-fatigue relationship in nasopharyngeal cancer (NPC) survivors. METHODS: Eighty disease-free NPC survivors completed the MD Anderson Symptom Inventory-Head and Neck module (MDASI-HN) after RT. Fatigue was evaluated by the MDASI-HN fatigue item (MDASI-HN-F) and Common Terminology Criteria for Adverse Events v3.0 (CTC-AE), between 6 and 36 months after RT to determine the presence of chronic fatigue. Skull base MRIs and planning CT/RT dose were retrievable for 56 patients. Dosimetric data were extracted for 10 MRI-defined p...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 1, 2019 Category: Radiology Authors: MD Anderson Head Neck Cancer Symptom Working Group Tags: Radiother Oncol Source Type: research

Volume not number of metastases: Gamma Knife radiosurgery management of intracranial lesions from an Australian perspective.
CONCLUSION: Results from the first Gamma Knife radiosurgery center in Australia showed that the treatment is feasible and effective, consistent with the international experience. For patients with larger numbers of intracranial metastases, the total volume of the intracranial burden may be of more significance in predicting outcomes. While there appeared to be a difference in survival by histologic origin, this could be related to concurrent systemic immunotherapy available for certain tumors. PMID: 30935580 [PubMed - in process] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 1, 2019 Category: Radiology Authors: Izard MA, Moutrie V, Rogers JM, Beath K, Grace M, Karle B, Ho A, Fuller JW Tags: Radiother Oncol Source Type: research

Adjuvant radiation therapy for T4 non-rectal colon adenocarcinoma provides a cause-specific survival advantage: A SEER database analysis.
CONCLUSIONS: Adjuvant RT is not routinely utilized for definitive treatment of T4 non-rectal colon cancer, but this analysis shows a significant cause-specific survival benefit. PMID: 30935581 [PubMed - in process] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 1, 2019 Category: Radiology Authors: McLaughlin C, Kim NK, Bandyopadhyay D, Deng X, Kaplan B, Matin K, Fields EC Tags: Radiother Oncol Source Type: research

Proton beam therapy outcomes for localized unresectable hepatocellular carcinoma.
This study documents the utilization and efficacy of proton beam therapy (PBT) in western patients with localized unresectable hepatocellular carcinoma (HCC). METHODS AND METHODS: Forty-six patients with HCC, Child-Pugh class of A or B, no prior radiotherapy history, and ECOG performance status 0-2 received PBT at our institution from 2007 to 2016. Radiographic control within the PBT field (local control, LC) and overall survival (OS) were calculated from the start of PBT. RESULTS: Most (83%) patients had Child-Pugh class A. Median tumor size was 6 cm (range, 1.5-21.0 cm); 22% of patients had multiple tumors ...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 1, 2019 Category: Radiology Authors: Chadha AS, Gunther JR, Hsieh CE, Aliru M, Mahadevan LS, Venkatesulu BP, Crane CH, Das P, Herman JM, Koay EJ, Taniguchi C, Holliday EB, Minsky BD, Suh Y, Park P, Sawakuchi G, Beddar S, Odisio BC, Gupta S, Loyer E, Kaur H, Raghav K, Javle MM, Kaseb AO, Kris Tags: Radiother Oncol Source Type: research

Impact of a dominant intraprostatic lesion (DIL) boost defined by sextant biopsy in permanent I-125 prostate implants on biochemical disease free survival (bDFS) and toxicity outcomes.
CONCLUSIONS: Boost to DIL defined by sextant biopsy with permanent seed prostate implant shows a trend toward improvement of biochemical control in intermediate risk prostate cancer patient without increasing toxicity. PMID: 30935583 [PubMed - in process] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 1, 2019 Category: Radiology Authors: Guimond E, Lavallée MC, Foster W, Vigneault É, Guay K, Martin AG Tags: Radiother Oncol Source Type: research

Ductal carcinoma in situ and intraoperative partial breast irradiation: Who are the best candidates? Long-term outcome of a single institution series.
BA Abstract AIMS: To report the long-term outcome of a single institution series of pure ductal carcinoma in situ (DCIS) treated with accelerated partial irradiation using intraoperative electrons (IOERT). METHODS: From 2000 to 2010, 180 DCIS patients, treated with quadrantectomy and 21 Gy IOERT, were analyzed in terms of ipsilateral breast recurrences (IBRs) and survival outcomes by stratification in two subgroups. The low-risk group included patients who fulfilled the suitable definition according to American Society of Radiation Oncology (ASTRO) Guidelines (size ≤2.5 cm, grade 1-2 and surgical marg...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 1, 2019 Category: Radiology Authors: Leonardi MC, Corrao G, Frassoni S, Vingiani A, Dicuonzo S, Lazzeroni M, Fodor C, Morra A, Gerardi MA, Rojas DP, Dell'Acqua V, Marvaso G, Bassi FD, Galimberti VE, Veronesi P, Miglietta E, Cattani F, Zurrida S, Bagnardi V, Viale G, Orecchia R, Jereczek-Foss Tags: Radiother Oncol Source Type: research

DNA damage response of clinical carbon ion versus photon radiation in human glioblastoma cells.
CONCLUSION: Carbon ions induced more severe DSB damage than photons, which was repaired less efficiently in both cell lines. Thus, carbon ion radiotherapy may help to overcome resistance mechanisms of glioblastoma associated with DNA repair for example in combination with repair pathway-specific drugs in the context of personalized radiotherapy. PMID: 30935585 [PubMed - in process] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 1, 2019 Category: Radiology Authors: Lopez Perez R, Nicolay NH, Wolf JC, Frister M, Schmezer P, Weber KJ, Huber PE Tags: Radiother Oncol Source Type: research

Dosimetric predictors for postoperative pulmonary complications in esophageal cancer following neoadjuvant chemoradiotherapy and surgery.
This study is carried out to identify the most reliable dosimetric predictors for pulmonary complications following NACRT and surgery for esophageal cancer. MATERIALS AND METHODS: We retrospectively reviewed the medical records of 308 patients with esophageal cancer who received surgery following NACRT for locally advanced esophageal cancer from January 2005 to June 2017. Dose-volume histograms (DVH) of both lungs were computed for each patient along with total lung volume, mean lung dose (MLD), V5, V10, V20, and V30. The effect of each parameter on postoperative pulmonary complications was estimated in univariate and...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 1, 2019 Category: Radiology Authors: Cho WK, Oh D, Kim HK, Ahn YC, Noh JM, Shim YM, Zo JI, Choi YS, Sun JM, Lee SH, Ahn MJ, Park K, Nam H Tags: Radiother Oncol Source Type: research

The relationship of lymphocyte recovery and prognosis of esophageal cancer patients with severe radiation-induced lymphopenia after chemoradiation therapy.
CONCLUSION: Lymphocyte count recovery after CRT does not alter the poor long-term outcomes brought about by high-grade lymphopenia during CRT. PMID: 30935587 [PubMed - in process] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 1, 2019 Category: Radiology Authors: Deng W, Xu C, Liu A, van Rossum PSN, Deng W, Liao Z, Koong AC, Mohan R, Lin SH Tags: Radiother Oncol Source Type: research

Synchrotron microbeam radiotherapy evokes a different early tumor immunomodulatory response to conventional radiotherapy in EMT6.5 mammary tumors.
CONCLUSION: Our data are the first to demonstrate substantial differences in macrophage, neutrophil and T cell numbers in tumors following MRT versus CRT, providing support for the concept that MRT evokes a different immunomodulatory response in tumors compared to CRT. PMID: 30935588 [PubMed - in process] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 1, 2019 Category: Radiology Authors: Yang Y, Swierczak A, Ibahim M, Paiva P, Cann L, Stevenson AW, Crosbie JC, Anderson RL, Rogers PAW Tags: Radiother Oncol Source Type: research

A prospective, three-arm, randomized trial of EGCG for preventing radiation-induced esophagitis in lung cancer patients receiving radiotherapy.
CONCLUSION: The application of EGCG could effectively alleviate acute radiation esophagitis in advanced lung cancer without obvious side effects. Prophylactic application of EGCG had a slight advantage over therapeutic use in treatment of acute esophagitis. PMID: 30898322 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 19, 2019 Category: Radiology Authors: Zhao H, Jia L, Chen G, Li X, Meng X, Zhao X, Xing L, Zhu W Tags: Radiother Oncol Source Type: research

Biological effects in normal cells exposed to FLASH dose rate protons.
CONCLUSIONS: In normal lung fibroblasts proton dose rate had little impact on acute effects, but significantly influenced the expression of long-term biological responses in vitro. Compared to conventional dose rates, protons delivered at FLASH dose rates mitigated such delayed detrimental effects. PMID: 30850209 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 5, 2019 Category: Radiology Authors: Buonanno M, Grilj V, Brenner DJ Tags: Radiother Oncol Source Type: research

Re-irradiation of locally recurrent pediatric intracranial ependymoma: Experience of the French society of children's cancer.
CONCLUSION: Local recurrence of brain ependymoma can be treated with full-dose re-irradiation, which can be hypofractionated with an acceptable short term toxicity in spite of high total doses delivered to OARs, especially brain stem. PMID: 30825956 [PubMed - in process] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 1, 2019 Category: Radiology Authors: Régnier E, Laprie A, Ducassou A, Bolle S, Supiot S, Muracciole X, Claude L, Chapet S, Coche-Dequéant B, Vigneron C, Leseur J, Bondiau PY, Habrand JL, Bernier V Tags: Radiother Oncol Source Type: research

Quantitative analysis of diffusion weighted imaging to predict pathological good response to neoadjuvant chemoradiation for locally advanced rectal cancer.
CONCLUSION: Combination of quantitative DWI analysis and clinical characteristics holds great potential in identifying the pGR patients and providing decision support for organ-preserving strategies after nCRT treatment. PMID: 30825957 [PubMed - in process] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 1, 2019 Category: Radiology Authors: Tang Z, Zhang XY, Liu Z, Li XT, Shi YJ, Wang S, Fang M, Shen C, Dong E, Sun YS, Tian J Tags: Radiother Oncol Source Type: research

Occurrence and mechanism of visual phosphenes in external photon beam radiation therapy and how to influence them.
CONCLUSIONS: We postulate that one should reduce the dose rate, instruct patients to keep the eyes open and increase the illuminance in the treatment room to reduce the probability of experiencing visual phosphenes. We hypothesize that melanopsin is involved in the visual phosphenes and that fatigue of patients might be correlated with the observation of visual phosphenes. PMID: 30825958 [PubMed - in process] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 1, 2019 Category: Radiology Authors: de Kruijf W, Timmers A, Dekker J, Böing-Messing F, Rozema T Tags: Radiother Oncol Source Type: research

MRI commissioning of 1.5T MR-linac systems - a multi-institutional study.
CONCLUSION: Our results highlight the importance of dedicated hybrid commissioning tests and the ability to compare the machines between institutes at this very early stage of clinical introduction. Until formal guidelines and tolerances are defined the tests described in this study may be used as a practical guideline. Moreover, the multi-center results provide initial bench mark data for future MR-linac installations. PMID: 30825959 [PubMed - in process] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 1, 2019 Category: Radiology Authors: Tijssen RHN, Philippens MEP, Paulson ES, Glitzner M, Chugh B, Wetscherek A, Dubec M, Wang J, van der Heide UA Tags: Radiother Oncol Source Type: research

Incidence and evolution of imaging changes on cone-beam CT during and after radical radiotherapy for non-small cell lung cancer.
CONCLUSION: Imaging changes on CBCT include real and apparent changes in tumour size and parenchymal changes which evolve during treatment. Correct image interpretation, particularly when occurring adjacent to the tumour, is essential prior to adjustment to treatment delivery. PMID: 30825960 [PubMed - in process] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 1, 2019 Category: Radiology Authors: Clarke E, Curtis J, Brada M Tags: Radiother Oncol Source Type: research

Patient specific outcomes of charged particle therapy for hepatocellular carcinoma - A systematic review and quantitative analysis.
CONCLUSIONS: CPT offers high local control, acceptable overall survival and low post-treatment morbidity. Quality of findings, especially on toxicities, is decreased by incomplete reporting and retrospective designs of available studies. Therefore, there is a strong need for better reporting and prospective studies. PMID: 30825961 [PubMed - in process] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 1, 2019 Category: Radiology Authors: Spychalski P, Kobiela J, Antoszewska M, Błażyńska-Spychalska A, Jereczek-Fossa BA, Høyer M Tags: Radiother Oncol Source Type: research

Phase I trial of alisertib with concurrent fractionated stereotactic re-irradiation for recurrent high grade gliomas.
CONCLUSION: Re-irradiation with FSRT combined with alisertib is safe and well tolerated for HGG with doses up to 40 mg BID. Although no DLT observed in the 50 mg cohort, this cohort was not fully enrolled and MTD was not reached. Clinical outcomes appear comparable to historical results. (NCT02186509). PMID: 30825962 [PubMed - in process] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 1, 2019 Category: Radiology Authors: Song A, Andrews DW, Werner-Wasik M, Kim L, Glass J, Bar-Ad V, Evans JJ, Farrell CJ, Judy KD, Daskalakis C, Zhan T, Shi W Tags: Radiother Oncol Source Type: research

Modeling radiation pneumonitis of pulmonary stereotactic body radiotherapy: The impact of a local dose-effect relationship for lung perfusion loss.
CONCLUSION: A LDE for perfusion loss provided modest improvement in NTCP model fit for SBRT induced radiation pneumonitis. PMID: 30825963 [PubMed - in process] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 1, 2019 Category: Radiology Authors: Selvaray J, Lebesque J, Hope A, Guckenberger M, Werner-Wasik M, Peulen H, Giuliani M, Mantel F, Belderbos J, Grills I, Sonke JJ Tags: Radiother Oncol Source Type: research

Identification of patients with locally advanced pancreatic cancer benefitting from plan adaptation in MR-guided radiation therapy.
CONCLUSION: MRgRT with daily plan adaptation for LAPC was of benefit in approximately half of fractions, improving target coverage and OAR sparing. Plan adaptation appeared to be relevant mainly in cases where the GTV to adjacent OAR distance was ≤3 mm. PMID: 30825964 [PubMed - in process] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 1, 2019 Category: Radiology Authors: Bohoudi O, Bruynzeel AME, Meijerink MR, Senan S, Slotman BJ, Palacios MA, Lagerwaard FJ Tags: Radiother Oncol Source Type: research

Optimal timing of thoracic radiotherapy in limited stage small cell lung cancer (SCLC) with daily fractionation: A brief report.
Abstract Survival in limited stage small cell lung cancer (LS-SCLC) improves with faster initiation of hyper-fractionated thoracic radiotherapy (TRT) following chemotherapy, however, it is unknown if this association exists for more commonly employed daily fractionated regimens. Our results suggest that this association is present even with daily fractionation. PMID: 30825965 [PubMed - in process] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 1, 2019 Category: Radiology Authors: Hasan S, White R, Renz P, Abel S, Otaibi Z, Monga D, Colonias A, Wegner RE Tags: Radiother Oncol Source Type: research

Identifying early diffusion imaging biomarkers of regional white matter injury as indicators of executive function decline following brain radiotherapy: A prospective clinical trial in primary brain tumor patients.
CONCLUSION: White matter underlying the AC may be particularly vulnerable to radiation effects. Early microstructural loss within AC SWM represents an important biomarker for EF decline, and dose reduction in this region may represent a possibility for cognitive preservation for patients receiving radiotherapy. PMID: 30825966 [PubMed - in process] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 1, 2019 Category: Radiology Authors: Tringale KR, Nguyen T, Bahrami N, Marshall DC, Leyden KM, Karunamuni R, Seibert TM, Kay Gorman M, Connor M, Burkeen J, Piccioni DE, Farid N, Hattangadi-Gluth JA, McDonald CR Tags: Radiother Oncol Source Type: research

A nomogram for the prediction of cerebrovascular disease among patients with brain necrosis after radiotherapy for nasopharyngeal carcinoma.
CONCLUSION: The nomogram showed favorable predictive accuracy for CVD among patients with brain necrosis after radiotherapy for NPC and might aid in clinical decision making. PMID: 30825967 [PubMed - in process] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 1, 2019 Category: Radiology Authors: Cai J, Cheng J, Li H, Lin WJ, Li Y, Zhuo X, Huang X, Simone CB, Aronow WS, Chow ELW, Tang Y Tags: Radiother Oncol Source Type: research

Stereotactic body radiotherapy dose and its impact on local control and overall survival of patients for locally advanced intrahepatic and extrahepatic cholangiocarcinoma.
CONCLUSION: This is the largest reported series on SBRT in cholangiocarcinoma. Overall survival and local control were significantly improved after higher doses (BED) and tolerance was excellent. PMID: 30825968 [PubMed - in process] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 1, 2019 Category: Radiology Authors: Brunner TB, Blanck O, Lewitzki V, Abbasi-Senger N, Momm F, Riesterer O, Duma MN, Wachter S, Baus W, Gerum S, Guckenberger M, Gkika E Tags: Radiother Oncol Source Type: research

Postmastectomy radiation therapy for triple negative, node-negative breast cancer.
CONCLUSIONS: In the largest study to date evaluating the use of PMRT in patients with node-negative TNBC, the use of PMRT was low in patients with T1 and T2 disease. Additionally, while an OS benefit was observed with the use of PMRT in patients with T3 disease, there was no benefit with the use of PMRT in other T stage groups. Further prospective studies are recommended to further elucidate the benefit on PMRT in patients with node-negative TNBC. PMID: 30825969 [PubMed - in process] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 1, 2019 Category: Radiology Authors: Haque W, Verma V, Farach A, Brian Butler E, Teh BS Tags: Radiother Oncol Source Type: research

Phase I trial of concurrent stereotactic body radiotherapy and nelfinavir for locally advanced borderline or unresectable pancreatic adenocarcinoma.
CONCLUSIONS: Concurrent SBRT (40 Gy)/NFV (1250 mg BID) for locally advanced pancreatic cancer is feasible and safe, although careful attention to treatment planning parameters is recommended to reduce the incidence of late gastrointestinal bleeding. PMID: 30825970 [PubMed - in process] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 1, 2019 Category: Radiology Authors: Lin C, Verma V, Ly QP, Lazenby A, Sasson A, Schwarz JK, Meza JL, Are C, Li S, Wang S, Hahn SM, Grem JL Tags: Radiother Oncol Source Type: research

Radiotherapy quality assurance of SBRT for patients with centrally located lung tumours within the multicentre phase II EORTC Lungtech trial: Benchmark case results.
CONCLUSIONS: Clinical guidelines and radiotherapy protocols are not a substitute for timely radiotherapy quality assurance procedures, which improve dose coverage significantly. Delineation remains the main source of BC rejection and plan review without first reviewing delineation may not be efficient. Our results show that delineation variations seem to have a larger influence on PTV coverage than variations in planning and irradiation techniques and thus suggest that dose tolerance criteria should preferably take into account the accuracy of delineation. PMID: 30825971 [PubMed - in process] (Source: Radiotherapy and...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 1, 2019 Category: Radiology Authors: Lambrecht M, Clementel E, Sonke JJ, Nestle U, Adebahr S, Guckenberger M, Andratschke N, Weber DC, Verheij M, Hurkmans CW Tags: Radiother Oncol Source Type: research

Linac-based radiosurgery for multiple brain metastases: Comparison between two mono-isocenter techniques with multiple non-coplanar arcs.
Abstract BACKGROUND AND PURPOSE: Three mono-isocenter techniques with multiple non-coplanar arcs are nowadays clinically available for linac-based stereotactic radiosurgery (SRS) of multiple brain metastases (BM): HyperArc (HA), Multiple Brain Mets (MBM), and Monaco-HDRS. Two of them, HA and MBM, are here compared in terms of plan-quality, and dosimetric consistency between planning and delivering. MATERIALS AND METHODS: For 20 patients with multiple BM (2-10), treated by mono-isocenter volumetric modulated arc therapy (VMAT) HA plans, mono-isocenter MBM dynamic conformal arc plans were generated. Prescriptio...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 1, 2019 Category: Radiology Authors: Ruggieri R, Naccarato S, Mazzola R, Ricchetti F, Corradini S, Fiorentino A, Alongi F Tags: Radiother Oncol Source Type: research

Impact of radiotherapy on anorectal function in patients with rectal cancer following a watch and wait programme.
CONCLUSIONS: This is the first study to investigate the late dose-volume effects of radiotherapy specifically on the anorectal function in rectal cancer patients. One-third of the patients had major LARS and the most frequent reported complaints were clustering and faecal urgency. Additionally, we observed trends towards worse long-term anorectal function after higher anal sphincter complex radiotherapy dose. However, this should be evaluated on a larger scale. Future efforts to minimise the dose to the sphincters could possibly reduce the impact of radiotherapy on the anorectal function. PMID: 30825973 [PubMed - in p...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 1, 2019 Category: Radiology Authors: van der Sande ME, Hupkens BJP, Berbée M, van Kuijk SMJ, Maas M, Melenhorst J, Beets GL, Breukink SO Tags: Radiother Oncol Source Type: research

1-(4-nitrobenzenesulfonyl)-4-penylpiperazine increases the number of Peyer's patch-associated regenerating crypts in the small intestines after radiation injury.
CONCLUSION: In summary, our study provides evidence that Compound #5 leads to an influx of immune cells into GALT, thereby supporting crypt regeneration preferentially in the proximity of Peyer's patches. PMID: 30825974 [PubMed - in process] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 1, 2019 Category: Radiology Authors: Bhat K, Duhachek-Muggy S, Ramanathan R, Saki M, Alli C, Medina P, Damoiseaux R, Whitelegge J, McBride WH, Schaue D, Vlashi E, Pajonk F Tags: Radiother Oncol Source Type: research

Auto-planning for VMAT accelerated partial breast irradiation.
CONCLUSION: Automatic planning for VMAT APBI was always at least equivalent and overall superior to manual planning. PMID: 30825975 [PubMed - in process] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 1, 2019 Category: Radiology Authors: Marrazzo L, Meattini I, Arilli C, Calusi S, Casati M, Talamonti C, Livi L, Pallotta S Tags: Radiother Oncol Source Type: research

MRI visibility of gold fiducial markers for image-guided radiotherapy of rectal cancer.
CONCLUSION: The Visicoil 0.75 and Gold Anchor fiducials were the most visible fiducials on MRI as they were most consistently identified. The use of a registered (CB)CT and a T1 3D GRE MRI sequence is recommended. PMID: 30825976 [PubMed - in process] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 1, 2019 Category: Radiology Authors: van den Ende RPJ, Rigter LS, Kerkhof EM, van Persijn van Meerten EL, Rijkmans EC, Lambregts DMJ, van Triest B, van Leerdam ME, Staring M, Marijnen CAM, van der Heide UA Tags: Radiother Oncol Source Type: research

Corrigendum to "Geometric uncertainties in voluntary deep inspiration breath hold radiotherapy for locally advanced lung cancer" [Radiother. Oncol. 118 (2016) 510-514].
Corrigendum to "Geometric uncertainties in voluntary deep inspiration breath hold radiotherapy for locally advanced lung cancer" [Radiother. Oncol. 118 (2016) 510-514]. Radiother Oncol. 2019 Feb 14;: Authors: Josipovic M, Persson GF, Dueck J, Peter Bangsgaard J, Westman G, Specht L, Aznar MC PMID: 30773227 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 14, 2019 Category: Radiology Authors: Josipovic M, Persson GF, Dueck J, Peter Bangsgaard J, Westman G, Specht L, Aznar MC Tags: Radiother Oncol Source Type: research

Modifying a clinical linear accelerator for delivery of ultra-high dose rate irradiation.
CONCLUSIONS: A clinical accelerator was modified to produce ultra-high dose rates, high enough for FLASH irradiation. Future work aims to fine-tune the dose delivery, using the on-board transmission chamber signal and adjusting the dose-per-pulse. PMID: 30755324 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 9, 2019 Category: Radiology Authors: Lempart M, Blad B, Adrian G, Bäck S, Knöös T, Ceberg C, Petersson K Tags: Radiother Oncol Source Type: research

Are hypothyroidism and hypogonadism clinically relevant in patients with malignant gliomas? A longitudinal trial in patients with glioma.
PMID: 30712840 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 31, 2019 Category: Radiology Authors: Bunevicius A Tags: Radiother Oncol Source Type: research

Response to Golden DW et al "A global call for increased interdisciplinary oncologic education".
Response to Golden DW et al "A global call for increased interdisciplinary oncologic education". Radiother Oncol. 2019 Jan 11;: Authors: O'Higgins N, Grau-Eriksen J, Wyld L, Benstead K PMID: 30642684 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 11, 2019 Category: Radiology Authors: O'Higgins N, Grau-Eriksen J, Wyld L, Benstead K Tags: Radiother Oncol Source Type: research

A global call for increased interdisciplinary oncologic education.
PMID: 30642685 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 11, 2019 Category: Radiology Authors: Akthar AS, Golden DW Tags: Radiother Oncol Source Type: research

Corrigendum to "Dose painting by numbers based on retrospectively determined recurrence probabilities" [Radiother Oncol 122 (2017) 236-241].
Corrigendum to "Dose painting by numbers based on retrospectively determined recurrence probabilities" [Radiother Oncol 122 (2017) 236-241]. Radiother Oncol. 2018 Dec 15;: Authors: Grönlund E, Johansson S, Montelius A, Ahnesjö A PMID: 30563693 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 15, 2018 Category: Radiology Authors: Grönlund E, Johansson S, Montelius A, Ahnesjö A Tags: Radiother Oncol Source Type: research

Functional Swallowing Units (FSUs) as organs-at-risk for radiotherapy. PART 2: Advanced delineation guidelines for FSUs.
CONCLUSIONS: Detailed delineation guidelines are presented for seven FSUs involved in HLE, TBR and tongue motion. The guidelines are supplemented by CT and MRI-based exemplary illustrations and complete CT/MRI-based delineation atlases (available online). This paper provides information essential to the implementation of the FSU concept in radiation practice, and supports uniform contouring, data collection and further improvement of swallowing sparing radiation-based strategies. PMID: 30551889 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 11, 2018 Category: Radiology Authors: Gawryszuk A, Bijl HP, Holwerda M, Halmos GB, Wedman J, Witjes MJH, van der Vliet AM, Dorgelo B, Langendijk JA Tags: Radiother Oncol Source Type: research

Prognostic factors and patterns of failure in advanced stage Hodgkin lymphoma treated with combined modality therapy.
CONCLUSION: Patients with advanced stage Hodgkin lymphoma treated with combined modality therapy including consolidative radiotherapy to bulky disease sites had excellent long-term outcomes. Given the low frequency of isolated failures at initial sites, our results suggest that selective radiation therapy to sites at high risk of relapse may be feasible. PMID: 30539763 [PubMed - in process] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 1, 2018 Category: Radiology Authors: Moding EJ, Advani R, Rosenberg SA, Hoppe RT Tags: Radiother Oncol Source Type: research

UV scintillating particles as radiosensitizer enhance cell killing after X-ray excitation.
CONCLUSION: Combining NPs with ionizing radiation results in a localized dose surge, which could increase tumor control. It could also allow lowering the total applied dose to minimize unwanted side effects to the surrounding normal tissue while maintaining tumor control. PMID: 30539764 [PubMed - in process] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 1, 2018 Category: Radiology Authors: Müller M, Wang Y, Squillante MR, Held KD, Anderson RR, Purschke M Tags: Radiother Oncol Source Type: research

Independent knowledge-based treatment planning QA to audit Pinnacle autoplanning.
Abstract BACKGROUND AND PURPOSE: With the advent of automatic treatment planning options like Pinnacle's Autoplanning (PAP), the challenge arises how to assess the quality of a plan that no dosimetrist did work on. The aim of this study was to assess plan quality consistency of PAP prostate cancer patients in clinical practice. MATERIALS AND METHODS: 100 prostate cancer patients were included from NKI and 129 from RadboudUMC (RUMC). Per institute a previously developed [1] treatment planning QA model, based on overlap volume histograms, was trained on PAP plans to predict achievable dose metrics which were th...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 14, 2018 Category: Radiology Authors: Janssen TM, Kusters M, Wang Y, Wortel G, Monshouwer R, Damen E, Petit SF Tags: Radiother Oncol Source Type: research

Survival impact of radiotherapy interruption in nasopharyngeal carcinoma in the intensity-modulated radiotherapy era: A big-data intelligence platform-based analysis.
Abstract PURPOSE: To evaluate the effect of radiotherapy interruption (RTI) in patients with nasopharyngeal carcinoma (NPC) receiving intensity-modulated radiotherapy (IMRT). PATIENTS AND METHODS: A total of 7826 patients using the well-established big-data intelligence platform were identified. Computer-generated random numbers were used to assign these patients into a training cohort (n = 3913 patients) and an internal validation cohort (n = 3913 patients). RTI was defined as the difference between radiation treatment time and planned radiation time (assuming a Monday start). Survival analysis was p...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 14, 2018 Category: Radiology Authors: Yao JJ, Zhang F, Gao TS, Zhang WJ, Lawrence WR, Zhu BT, Zhou GQ, Ma J, Wang SY, Sun Y Tags: Radiother Oncol Source Type: research

4D liver tumor localization using cone-beam projections and a biomechanical model.
CONCLUSIONS: Bio-CBCT-est substantially improves the accuracy of 4D liver tumor localization via cone-beam projections and a biomechanical model. PMID: 30448003 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 14, 2018 Category: Radiology Authors: Zhang Y, Folkert MR, Li B, Huang X, Meyer JJ, Chiu T, Lee P, Tehrani JN, Cai J, Parsons D, Jia X, Wang J Tags: Radiother Oncol Source Type: research

Corrigendum to: "Nuclear EGFR as a molecular target in cancer" [Radiother Oncol 108 (2013) 370-77].
Corrigendum to: "Nuclear EGFR as a molecular target in cancer" [Radiother Oncol 108 (2013) 370-77]. Radiother Oncol. 2018 Nov 13;: Authors: Brand TM, Iida M, Luthar N, Starr MM, Huppert EJ, Wheeler DL PMID: 30442378 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 13, 2018 Category: Radiology Authors: Brand TM, Iida M, Luthar N, Starr MM, Huppert EJ, Wheeler DL Tags: Radiother Oncol Source Type: research