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Patterns of re-irradiation for recurrent gliomas and validation of a prognostic score.
This study aims to compare the efficacy and safety of different treatment regimens and to independently externally validate a recently published reirradiation risk score. MATERIAL AND METHODS: We retrospectively analyzed a cohort of patients with recurrent malignant glioma treated with salvage conventionally fractionated (CFRT), hypofractionated (HFRT) or stereotactic radiotherapy (SRT) between 2007 and 2017 at the University Medical Centers in Utrecht and Groningen. RESULTS: Of the 121 patients included, 60 patients (50%) underwent CFRT, 22 (18%) HFRT and 39 (32%) SRT. The primary tumor was grade II-III in 52 pa...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 13, 2018 Category: Radiology Authors: Post CCB, Kramer MCA, Smid EJ, van der Weide HL, Kleynen CE, Heesters MAAM, Verhoeff JJC Tags: Radiother Oncol Source Type: research

Influence of volumetric modulated arc therapy and FET-PET scanning on treatment outcomes for glioblastoma patients.
Abstract BACKGROUND: We sought to assess the influence of the clinical introduction of new radiotherapy technologies on glioblastoma patients' outcomes. METHODS: Newly diagnosed glioblastoma patients treated with 60 Gy and temozolomide (2005-2014) were analyzed. The patients' GTV and CTV were defined based on MR (n = 521) or FET-PET/MR (n = 190), and were treated using conformal radiotherapy (CRT, n = 159) or image-guided volumetric modulated arc therapy with hippocampal sparing (IG-VMAT, n = 362). Progression-free survival (PFS) was assessed using the McDonald criteria. Associations between...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 13, 2018 Category: Radiology Authors: Munck Af Rosenschold P, Law I, Engelholm S, Engelholm SA, Muhic A, Lundemann MJ, Roed H, Grunnet K, Skovgaard Poulsen H Tags: Radiother Oncol Source Type: research

Comment on Long-term risks of secondary cancer for various whole and partial breast irradiation techniques.
PMID: 30446317 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 13, 2018 Category: Radiology Authors: Ghaznavi H Tags: Radiother Oncol Source Type: research

Quantification of cardiac subvolume dosimetry using a 17 segment model of the left ventricle in breast cancer patients receiving tangential beam radiotherapy.
This study aims to determine doses to the 17 segments of the LV as per the American Heart Association (AHA) and other cardiac subvolumes, and to correlate mean heart (MHD) dose with various subvolume dosimetric indices. These results may direct focus to specific left ventricular segments in studies of radiation-related heart disease incorporating surveillance imaging, help to determine more precise dose response relationships, and potentially aid prediction of late radiation effects. METHODS AND MATERIALS: The heart and cardiac subvolumes of 29 patients treated with tangential radiotherapy for left breast cancer were ...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 13, 2018 Category: Radiology Authors: Tang S, Otton J, Holloway L, Delaney GP, Liney G, George A, Jameson M, Tran D, Batumalai V, Thomas L, Koh ES Tags: Radiother Oncol Source Type: research

Reply to Laprie A. et al.
PMID: 30446319 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 13, 2018 Category: Radiology Authors: Langendijk JA, Troost EGC, Haustermans K, Grau C, Weber DC Tags: Radiother Oncol Source Type: research

Location of arm draining lymph node in relation to breast cancer radiotherapy field and target volume.
CONCLUSIONS: Our study demonstrates that the vast majority of ARM nodes (72%) are outside the tangential whole breast radiotherapy fields. In our study, all the ARM nodes were within the axillary radiotherapy fields covering level 1-4 axillary volumes according to the ESTRO contouring guideline, and complete shielding of the humeral head according to the EORTC consensus did not lead to sparing of the ARM nodes. A prospective study is needed to examine the oncological safety of ARM node-sparing axillary radiotherapy and its potential to reduce the risk of arm lymphoedema. PMID: 30446320 [PubMed - as supplied by publish...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 13, 2018 Category: Radiology Authors: Wang W, Ward R, Jia D, Ashworth S, Estoesta E, Moodie T, Ahern V, Stuart K, Ngui N, French J, Elder E, Farlow D Tags: Radiother Oncol Source Type: research

External validation of a prognostic model incorporating quantitative PET image features in oesophageal cancer.
CONCLUSION: The prognostic model did not enable significant discrimination between the validation risk groups, but a second model with exclusively clinical variables suggested some transferable prognostic ability. PET harmonisation did not significantly change the results of model validation. PMID: 30424894 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 10, 2018 Category: Radiology Authors: Foley KG, Shi Z, Whybra P, Kalendralis P, Larue R, Berbee M, Sosef MN, Parkinson C, Staffurth J, Crosby TDL, Roberts SA, Dekker A, Wee L, Spezi E Tags: Radiother Oncol Source Type: research

Use of a novel atlas for muscles of mastication to reduce inter observer variability in head and neck radiotherapy contouring.
This study aimed to evaluate the reduction in interobserver variability achievable with a new contouring atlas. MATERIALS/METHODS: The atlas included: medial and lateral pterygoids (MP, LP), masseter (M) and temporalis (T) muscles, and the temporo-mandibular joint (TMJ). Seven clinicians delineated five paired structures on CT scans from 5 patients without the atlas. After ≥5 weeks, contouring was repeated using the atlas. Using contours generated by the clinicians on the same 5 CT scans as reference, dice similarity coefficient (DSC), mean distance-to-agreement (DTA) and centre of mass (COM) difference were comp...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 9, 2018 Category: Radiology Authors: Hague C, Beasley W, Dixon L, Gaito S, Garcez K, Green A, Lee LW, Maranzano M, McPartlin A, Mistry H, Mullan D, Sykes AJ, Thomson D, Van Herk M, West CM, Slevin N Tags: Radiother Oncol Source Type: research

Functional Swallowing Units (FSUs) as organs-at-risk for radiotherapy. PART 1: Physiology and anatomy.
CONCLUSION: Functional swallowing units (FSUs) were defined as groups of swallowing muscles sharing their function, that are in close proximity to each other. Seven FSUs involved in HLE, TBR and tongue motion were identified: floor of mouth, thyrohyoid muscles, posterior digastric/stylohyoid muscles complex, longitudinal pharyngeal muscles, hyoglossus/styloglossus muscles complex, genioglossus muscles, intrinsic tongue muscles. The swallowing physiology and anatomy of the FSUs described in this paper will lead to a greater understanding of radiation-induced dysphagia mechanisms and, consequently, to an improvement in the d...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 9, 2018 Category: Radiology Authors: Gawryszuk A, Bijl HP, Holwerda M, Halmos GB, Wedman J, Witjes MJH, van der Vliet AM, Dorgelo B, Langendijk JA Tags: Radiother Oncol Source Type: research

Vulnerabilities of radiomic signature development: The need for safeguards.
CONCLUSION: Our experiments reveal vulnerabilities in radiomic signature development processes and suggest safeguards that can be used to refine methodologies, and ensure productive radiomic development using objective and independent features. PMID: 30416044 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 8, 2018 Category: Radiology Authors: Welch ML, McIntosh C, Haibe-Kains B, Milosevic MF, Wee L, Dekker A, Huang SH, Purdie TG, O'Sullivan B, Aerts HJWL, Jaffray DA Tags: Radiother Oncol Source Type: research

High-dose-rate brachytherapy monotherapy versus low-dose-rate brachytherapy with or without external beam radiotherapy for clinically localized prostate cancer.
CONCLUSION: HDR-BT monotherapy showed an equivalent outcome to that of LDR-BT with or without EBRT for low-, intermediate- and selected high-risk patients. LDR-BT showed equivalent incidence of grade ≥2 late GI and GU toxicities and higher grade ≥2 acute GU toxicity as that of HDR-BT as a monotherapy. PMID: 30416045 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 8, 2018 Category: Radiology Authors: Yamazaki H, Masui K, Suzuki G, Nakamura S, Yamada K, Okihara K, Shiraishi T, Yoshida K, Kotsuma T, Tanaka E, Otani K, Yoshioka Y, Ogawa K Tags: Radiother Oncol Source Type: research

Doses of radiation to the pericardium, instead of heart, are significant for survival in patients with non-small cell lung cancer.
CONCLUSION: PCE was associated with both heart and pericardial doses. The significance of pericardial dosimetric parameters, but not heart chamber parameters, on survival suggests the potential significance of radiation damage to the cranial region of pericardium. PMID: 30416046 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 8, 2018 Category: Radiology Authors: Xue J, Han C, Jackson A, Hu C, Yao H, Wang W, Hayman J, Chen W, Jin J, Kalemkerian GP, Matuzsak M, Jolly S, Kong FS Tags: Radiother Oncol Source Type: research

Predictive factors for survival of oligometastatic colorectal cancer treated with Stereotactic body radiation therapy.
CONCLUSIONS: Stereotactic body radiation therapy represents an effective approach in the management of oligometastatic CRC. Control of treated oligometastases seems to be a strong positive predictive factor for both PFS and OS. PMID: 30414754 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 7, 2018 Category: Radiology Authors: Franzese C, Comito T, Toska E, Tozzi A, Clerici E, De Rose F, Franceschini D, Navarria P, Reggiori G, Tomatis S, Scorsetti M Tags: Radiother Oncol Source Type: research

Persistent reduction in global longitudinal strain in the longer term after radiation therapy in patients with breast cancer.
CONCLUSIONS: Subclinical cardiac dysfunction using strain analysis, evident early, persists one year after RT, despite unchanged conventional indices such as LVEF. Persistent GLS reduction may be of particular importance in breast cancer patients receiving concomitant chemotherapy. Longer term prospective studies are required to determine if reductions in strain post-RT are associated with future adverse cardiovascular events. PMID: 30414755 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 7, 2018 Category: Radiology Authors: Trivedi SJ, Choudhary P, Lo Q, Sritharan HP, Iyer A, Batumalai V, Delaney GP, Thomas L Tags: Radiother Oncol Source Type: research

Delineation guideline for the para-aortic lymph node region in cervical cancer - Clarification letter.
PMID: 30414756 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 7, 2018 Category: Radiology Authors: Keenan LG, McArdle O Tags: Radiother Oncol Source Type: research

Early outcomes of breast cancer patients treated with post-mastectomy uniform scanning proton therapy.
CONCLUSION: With close to three years of median follow-up, post-mastectomy proton radiation has shown excellent locoregional control rates and favorable toxicity profile. Long-term adverse effect of heart-sparing radiation will require longer follow-up time and randomized clinical trials. PMID: 30414757 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 7, 2018 Category: Radiology Authors: Luo L, Cuaron J, Braunstein L, Gillespie E, Kahn A, McCormick B, Mah D, Chon B, Tsai H, Powell S, Cahlon O Tags: Radiother Oncol Source Type: research

Epoetin receptor status may alter the outcomes in head and neck cancers treated with radiotherapy and darbepoetin- α.
Epoetin receptor status may alter the outcomes in head and neck cancers treated with radiotherapy and darbepoetin-α. Radiother Oncol. 2018 Nov 07;: Authors: Topkan E, Yildirim BA PMID: 30414758 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 7, 2018 Category: Radiology Authors: Topkan E, Yildirim BA Tags: Radiother Oncol Source Type: research

Patterns of proton therapy use in pediatric cancer management in 2016: An international survey.
, Murakami M, Murayama S, Ogino T, Ondrová B, Parikh RR, Paulino AC, Perkins S, Ramakrishna NR, Richter R, Rombi B, Shibata S, Shimizu S, Timmermann B, Vern-Gross T, Wang CJ, Weber DC, Wilkinson JB, Witt Nyström P, Yock TI, Kleinerman RA, Berrington de Gonzalez A Abstract PURPOSE: To facilitate the initiation of observational studies on late effects of proton therapy in pediatric patients, we report on current patterns of proton therapy use worldwide in patients aged less than 22 years. MATERIALS & METHODS: Fifty-four proton centers treating pediatric patients in 2016 in 11 countries were in...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 7, 2018 Category: Radiology Authors: Journy N, Indelicato DJ, Withrow DR, Akimoto T, Alapetite C, Araya M, Chang A, Chang JH, Chon B, Confer ME, Demizu Y, Dendale R, Doyen J, Ermoian R, Gurtner K, Hill-Kayser C, Iwata H, Kim JY, Kwok Y, Laack NN, Lee C, Lim DH, Loredo L, Mangona VS, Mansur D Tags: Radiother Oncol Source Type: research

Deep learning provides a new computed tomography-based prognostic biomarker for recurrence prediction in high-grade serous ovarian cancer.
CONCLUSIONS: The DL method extracts effective CT-based prognostic biomarkers for HGSOC, and provides a non-invasive and preoperative model for individualized recurrence prediction in HGSOC. In addition, the DL-CPH model provides a new prognostic analysis method that can utilize CT data without follow-up for prognostic biomarker extraction. PMID: 30392780 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 1, 2018 Category: Radiology Authors: Wang S, Liu Z, Rong Y, Zhou B, Bai Y, Wei W, Wei W, Wang M, Guo Y, Tian J Tags: Radiother Oncol Source Type: research

Improving outcomes in non-small cell lung cancer; population analysis of radical radiotherapy.
Abstract AIM: Regional utilisation of radical radiotherapy (RT) in non-small cell lung cancer (NSCLC) was used to define optimal utilisation to improve outcome and as a surrogate for evidence of RT efficacy. PATIENTS & METHODS: 65,412 NSCLC cases diagnosed in England 2012-13 were linked to comprehensive national radiotherapy dataset, hospital admissions and the Office of National Statistics. Geographical variation in utilisation was determined using a multivariate binary logistic regression analysis after adjusting for age, stage, deprivation, comorbidity and other radical treatment and the effect of radi...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 1, 2018 Category: Radiology Authors: Brada M, Ball C, Mitchell S, Forbes H, Ashley S Tags: Radiother Oncol Source Type: research

Stereotactic body radiotherapy with adjuvant systemic therapy for early-stage non-small cell lung carcinoma: A multi-institutional analysis.
CONCLUSION: In this multi-institutional analysis, adjuvant ST was independently associated with reduced RDF in early-stage NSCLC patients treated with SBRT. PMID: 30391106 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 31, 2018 Category: Radiology Authors: Kann BH, Miccio JA, Stahl JM, Ross R, Verma V, Dosoretz AP, Park HS, Shafman TD, Gross CP, Yu JB, Decker RH Tags: Radiother Oncol Source Type: research

Greater reduction in mid-treatment FDG-PET volume may be associated with worse survival in non-small cell lung cancer.
CONCLUSION: Changes in mid-treatment PET-volumetric parameters were significantly associated with survival in NSCLC. A greater reduction in the mid-treatment MTV was associated with worse survival in patients treated with standard radiation, but with better survival in patients who received mid-treatment PET-adapted treatment. PMID: 30389239 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 30, 2018 Category: Radiology Authors: Kong FS, Li L, Wang W, Campbell J, Waller JL, Piert M, Gross M, Cheng M, Owen D, Stenmark M, Huang KC, Frey KA, Ten Haken RK, Lawrence TS Tags: Radiother Oncol Source Type: research

Are hypothyroidism and hypogonadism clinically relevant in patients with malignant gliomas? A longitudinal trial in patients with glioma.
DISCUSSION: The results of this study show that a significant percentage of patients with malignant gliomas develop hormonal deficiencies mandating regular clinical follow up, state of the art counseling and if clinically necessary substitution therapy. PMID: 30389240 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 30, 2018 Category: Radiology Authors: Handisurya A, Rumpold T, Caucig-Lütgendorf C, Flechl B, Preusser M, Ilhan-Mutlu A, Dieckmann K, Widhalm G, Grisold A, Wöhrer A, Hainfellner J, Ristl R, Kurz C, Marosi C, Gessl A, Hassler M Tags: Radiother Oncol Source Type: research

Ten-year survival after High-Dose-Rate Brachytherapy combined with External Beam Radiation Therapy in high-risk prostate cancer: A comparison with the Norwegian SPCG-7 cohort.
Lilleby W Abstract BACKGROUND: The survival benefit of dose-escalation with High-Dose-Rate brachytherapy (HDR-BT) boost combined with External Beam Radiotherapy (EBRT) for the treatment of high-risk prostate cancer (PCa) remains debatable. We investigated 10-year PCa-specific mortality (PCSM) and overall mortality (OM) in high-risk patients treated with HDR-BT/EBRT (calculated EQD2 = 102 Gy) compared to EBRT alone (70 Gy). METHODS: HDR-BT boosts (10 Gy × 2) were given 2 weeks apart followed by 50 Gy conformal EBRT (2 Gy × 25) to the prostate and seminal vesicles. The HDR-BT...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 30, 2018 Category: Radiology Authors: Wedde TB, Småstuen MC, Brabrand S, Fosså SD, Kaasa S, Tafjord G, Russnes KM, Hellebust TP, Lilleby W Tags: Radiother Oncol Source Type: research

Predicting severe acute radiation pneumonitis in patients with non-small cell lung cancer receiving postoperative radiotherapy: Development and internal validation of a nomogram based on the clinical and dose-volume histogram parameters.
CONCLUSION: We identified that the tlMD (>10.8 Gy), ilV5 (>64.9%), and CCRT could predict SARP among patients with NSCLC receiving PORT. Combining clinical and DVH parameters, a nomogram was first built and validated, showing its potential value in practice. PMID: 30385172 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 29, 2018 Category: Radiology Authors: Tang X, Li Y, Tian X, Zhou X, Wang Y, Huang M, Ren L, Zhou L, Xue J, Ding Z, Zhu J, Xu Y, Peng F, Wang J, Lu Y, Gong Y Tags: Radiother Oncol Source Type: research

Community approach for reducing small field measurement errors: Experience over 24 centres.
CONCLUSIONS: The proposed approach could allow one to envision high-skilled therapy centres providing support to those featuring minor experience and could represent an important strategy for the clinical implementation of emerging technologies at high quality levels. The methodology adopted exploits crowd knowledge methods which could be applied in others areas of radiation dosimetry. PMID: 30385173 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 29, 2018 Category: Radiology Authors: Talamonti C, Russo S, Pimpinella M, Falco MD, Cagni E, Pallotta S, Stasi M, Mancosu P Tags: Radiother Oncol Source Type: research

Total neoadjuvant treatment (CAPOX plus radiotherapy) for patients with locally advanced rectal cancer with high risk factors: A phase 2 trial.
CONCLUSIONS: TNT is effective and safe in patients with locally advanced rectal cancer with high risk factors. Long-term efficacies of TNT need to be further evaluated. This trial is registered with Chinese Clinical Trial Registry, number ChiCTR-OIN-17012284. PMID: 30381141 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 28, 2018 Category: Radiology Authors: Wang X, Yu Y, Meng W, Jiang D, Deng X, Wu B, Zhuang H, Wang C, Shen Y, Yang L, Zhu H, Cheng K, Zhao Y, Li Z, Qiu M, Gou H, Bi F, Xu F, Zhong R, Bai S, Wang Z, Zhou Z Tags: Radiother Oncol Source Type: research

Prognostic value of gross tumor regression and plasma Epstein Barr Virus DNA levels at the end of intensity-modulated radiation therapy in patients with nasopharyngeal carcinoma.
Abstract PURPOSE: To assess gross tumor regression and plasma Epstein-Barr virus (EBV)-DNA levels at the end of intensity-modulated radiation therapy (IMRT) and its prognostic impact on patients with nasopharyngeal carcinoma (NPC). PARTICIPANTS AND METHODS: In total, 397 patients with non-metastatic, histologically confirmed NPC were retrospectively examined. All patients underwent magnetic resonance imaging of the nasopharynx and neck, and plasma EBV DNA assays before treatment and at the end of IMRT. RESULTS: The estimated 5-year loco-regional, local and regional relapse-free survival rates for patient...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 23, 2018 Category: Radiology Authors: Liang SB, Zhang N, Chen DM, Yang XL, Chen BH, Zhao H, Lu RL, Chen Y, Fu LW Tags: Radiother Oncol Source Type: research

A feasibility study of high-dose hypofractionated carbon ion radiation therapy using four fractions for localized hepatocellular carcinoma measuring 3  cm or larger.
CONCLUSION: C-ion RT using 60 Gy (RBE) in four fractions was safe and achieved promising local tumor control. PMID: 30366726 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 23, 2018 Category: Radiology Authors: Shibuya K, Ohno T, Katoh H, Okamoto M, Shiba S, Koyama Y, Kakizaki S, Shirabe K, Nakano T Tags: Radiother Oncol Source Type: research

Letter to the Editor of Radiotherapy and Oncology regarding the paper entitled "Prospective Data Registration and Clinical Trials for Particle Therapy" by Langendijk et al.
Letter to the Editor of Radiotherapy and Oncology regarding the paper entitled "Prospective Data Registration and Clinical Trials for Particle Therapy" by Langendijk et al. Radiother Oncol. 2018 Oct 22;: Authors: Laprie A, Bernier V, Carrie C, French Group of Pediatric Radiotherapy GFRP .a.k.a. Radiotherapy Committee of French Society of Children's Cancer SFCE PMID: 30360997 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 22, 2018 Category: Radiology Authors: Laprie A, Bernier V, Carrie C, French Group of Pediatric Radiotherapy GFRP .a.k.a. Radiotherapy Committee of French Society of Children's Cancer SFCE Tags: Radiother Oncol Source Type: research

Carbon-ion radiotherapy for locally recurrent rectal cancer: Japan Carbon-ion Radiation Oncology Study Group (J-CROS) Study 1404 Rectum.
CONCLUSIONS: This first multi-institutional analysis of C-ion RT for LRRC indicated relatively favorable outcomes with limited toxicities. PMID: 30360998 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 22, 2018 Category: Radiology Authors: Shinoto M, Yamada S, Okamoto M, Shioyama Y, Ohno T, Nakano T, Nemoto K, Isozaki Y, Kawashiro S, Tsuji H, Kamada T Tags: Radiother Oncol Source Type: research

Analysis of EORTC-1219-DAHANCA-29 trial plans demonstrates the potential of knowledge-based planning to provide patient-specific treatment plan quality assurance.
DISCUSSION: Individualized QA indicated that OAR sparing could frequently be improved in EORTC-1219 study plans, even though they met the trial's generic plan criteria. Automated, patient-specific QA can be performed within a few minutes and should be considered to reduce the influence of planning variation on trial outcomes. PMID: 30348462 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 19, 2018 Category: Radiology Authors: Tol JP, Dahele M, Gregoire V, Overgaard J, Slotman BJ, Verbakel WFAR Tags: Radiother Oncol Source Type: research

Comments on "High lymphocyte count during neoadjuvant chemoradiotherapy is associated with improved pathologic complete response in esophageal cancer".
Comments on "High lymphocyte count during neoadjuvant chemoradiotherapy is associated with improved pathologic complete response in esophageal cancer". Radiother Oncol. 2018 Oct 17;: Authors: Yilmaz MT, Elmali A, Yazici G PMID: 30342795 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 17, 2018 Category: Radiology Authors: Yilmaz MT, Elmali A, Yazici G Tags: Radiother Oncol Source Type: research

Validation of a robust strategy for proton spot scanning for oesophageal cancer in the presence of anatomical changes.
ann L Abstract SFUD strategies with one or two posterior proton beams and three target coverage strategies are compared with IMRT and tested for robustness towards anatomical changes by recalculation on surveillance CTs during treatment. We find posterior beam SFUD combining PTV coverage with robust optimization increases robustness towards anatomical changes compared to IMRT. PMID: 30340776 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 16, 2018 Category: Radiology Authors: Møller DS, Alber M, Nordsmark M, Nyeng TB, Lutz CM, Hoffmann L Tags: Radiother Oncol Source Type: research

Intrafraction motion quantification and planning target volume margin determination of head-and-neck tumors using cine magnetic resonance imaging.
CONCLUSIONS: Intrafractional head-and-neck tumor motion was quantified and population-based PTV margins were calculated. Although the average tumor motion was small (95th percentile motion
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 15, 2018 Category: Radiology Authors: Bruijnen T, Stemkens B, Terhaard CHJ, Lagendijk JJW, Raaijmakers CPJ, Tijssen RHN Tags: Radiother Oncol Source Type: research

Severe acute radiation-induced enterocolitis after combined palbociclib and palliative radiotherapy treatment.
PMID: 30336956 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 15, 2018 Category: Radiology Authors: Kawamoto T, Shikama N, Sasai K Tags: Radiother Oncol Source Type: research

Imaging and radiotherapy for recurrent prostate cancer: An evolutionary partnership.
PMID: 30336957 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 15, 2018 Category: Radiology Authors: Murray JR, Kopka K, Afshar-Oromieh A Tags: Radiother Oncol Source Type: research

The acute and late toxicity results of a randomized phase II dose-escalation trial in non-small cell lung cancer (PET-boost trial).
CONCLUSION: Personalized dose-escalation in inoperable NSCLC patients results in higher acute and late toxicity compared to conventional chemoradiotherapy. The toxicity, however, was within the boundaries of the pre-defined stopping rules. PMID: 30327236 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 13, 2018 Category: Radiology Authors: van Diessen J, De Ruysscher D, Sonke JJ, Damen E, Sikorska K, Reymen B, van Elmpt W, Westman G, Fredberg Persson G, Dieleman E, Bjorkestrand H, Faivre-Finn C, Belderbos J Tags: Radiother Oncol Source Type: research

MSI1 associates glioblastoma radioresistance via homologous recombination repair, tumor invasion and cancer stem-like cell properties.
CONCLUSION: MSI1 may involve in regulating GBM radioresistance, invasion, and recurrence and could be a novel target for GBM treatment. PMID: 30322656 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 12, 2018 Category: Radiology Authors: Lin JC, Tsai JT, Chao TY, Ma HI, Chien CS, Liu WH Tags: Radiother Oncol Source Type: research

Volume effects of radiotherapy on the risk of second primary cancers: A systematic review of clinical and epidemiological studies.
Abstract As modern radiotherapy, including intensity-modulated techniques, is associated with high dose gradients to normal tissues and large low-to-moderate dose volumes, the assessment of second primary cancer (SPC) risks requires quantification of dose-volume effects. We conducted a systematic review of clinical and epidemiological studies investigating the effect of the irradiated volume or dose-volume distribution to the remaining volume at risk (RVR) on SPC incidence. We identified eighteen studies comparing SPC risks according to the irradiated volume (i.e., in most studies, the size or number of fields use...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 10, 2018 Category: Radiology Authors: Journy N, Mansouri I, Allodji RS, Demoor-Goldschmidt C, Ghazi D, Haddy N, Rubino C, Veres C, Zrafi WS, Rivera S, Diallo I, De Vathaire F Tags: Radiother Oncol Source Type: research

Toward adaptive proton therapy guided with a mobile helical CT scanner.
Abstract PURPOSE: To evaluate the feasibility of image-guided adaptive proton therapy (IGAPT) with a mobile helical-CT without rails. METHOD: CT images were acquired with a 32-slice mobile CT (mCT) scanning through a 6 degree-of-freedom robotic couch rotated isocentrically 90 degrees from an initial setup position. The relationship between the treatment isocenter and the mCT imaging isocenter was established by a stereotactic reference frame attached to the treatment couch. Imaging quality, geometric integrity and localization accuracy were evaluated according to AAPM TG-66. Accuracy of relative stopping powe...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 9, 2018 Category: Radiology Authors: Sun B, Yang D, Lam D, Zhang T, Dvergsten T, Bradley J, Mutic S, Zhao T Tags: Radiother Oncol Source Type: research

Competing risks in survival data analysis.
k S Abstract Clinical trials and retrospective studies in the field of radiation oncology often consider time-to-event data as their primary endpoint. Such studies are susceptible to competing risks, i.e. competing events may preclude the occurrence of the event of interest or modify the chance that the primary endpoint occurs. Competing risks are frequently neglected and the event of interest is analysed with standard statistical methods. Here, we would like to create awareness of the problem and demonstrate different methods for survival data analysis in the presence of competing risks. PMID: 30314718 [PubM...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 9, 2018 Category: Radiology Authors: Dutz A, Löck S Tags: Radiother Oncol Source Type: research

External validation of a multifactorial normal tissue complication probability model for tube feeding dependence at 6  months after definitive radiotherapy for head and neck cancer.
CONCLUSIONS: TUBEM6 at our institute was lower than that predicted by the original NTCP model. The closed testing procedure indicated that only an adjustment of the intercept was needed indicating the importance of external validation. PMID: 30301559 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 6, 2018 Category: Radiology Authors: Kanayama N, Kierkels RGJ, van der Schaaf A, Steenbakkers RJHM, Yoshioka Y, Nishiyama K, Fujii T, Ogawa K, Langendijk JA, Teshima T Tags: Radiother Oncol Source Type: research

FMISO-PET-based lymph node hypoxia adds to the prognostic value of tumor only hypoxia in HNSCC patients.
ost EGC Abstract PURPOSE: This secondary analysis of the prospective study on repeat [18F]fluoromisonidazole (FMISO)-PET in patients with locally advanced head and neck squamous cell carcinomas (HNSCC) assessed the prognostic value of synchronous hypoxia in primary tumor (Tu) and lymph node metastases (LN), and evaluated whether the combined reading was of higher prognostic value than that of primary tumor hypoxia only. METHODS: This analysis included forty-five LN-positive HNSCC patients. FMISO-PET/CTs were performed at baseline, weeks 1, 2 and 5 of radiochemotherapy. Based on a binary scale, Tu and LN were ...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 4, 2018 Category: Radiology Authors: Bandurska-Luque A, Löck S, Haase R, Richter C, Zöphel K, Abolmaali N, Seidlitz A, Appold S, Krause M, Steinbach J, Kotzerke J, Zips D, Baumann M, Troost EGC Tags: Radiother Oncol Source Type: research

Complications after stereotactic radiosurgery for brain metastases: Incidences, correlating factors, treatments and outcomes.
Abstract BACKGROUND AND PURPOSE: Complications after stereotactic radiosurgery (SRS) for brain metastases (BMs) were analyzed in detail using our database including nearly 3000 BM patients. MATERIALS AND METHODS: This was an institutional review board-approved, retrospective cohort study using our prospectively accumulated database including 3271 consecutive patients who underwent gamma knife SRS for BMs during the 1998-2016 period. Excluding four patients lost to follow-up, 112 with three-staged treatment and 189 with post-operative irradiation, 2966 who underwent a single-session of SRS only as radical irra...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 4, 2018 Category: Radiology Authors: Aiyama H, Yamamoto M, Kawabe T, Watanabe S, Koiso T, Sato Y, Higuchi Y, Ishikawa E, Yamamoto T, Matsumura A, Kasuya H, Barfod BE Tags: Radiother Oncol Source Type: research

Treatment outcomes for unresectable intrahepatic cholangiocarcinoma: Nationwide, population-based, cohort study based on propensity score matching with the Mahalanobis metric.
CONCLUSIONS: Definitive CCRT is the optimal therapy for patients with unresectable ICC without distant metastasis. PMID: 30279046 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 29, 2018 Category: Radiology Authors: Chang WW, Hsiao PK, Qin L, Chang CL, Chow JM, Wu SY Tags: Radiother Oncol Source Type: research

A cross sectional study in cognitive and neurobehavioral impairment in long-term nasopharyngeal cancer survivors treated with intensity-modulated radiotherapy.
Abstract PURPOSE/OBJECTIVES: To determine neurocognitive and neurobehavioral impairment in long-term nasopharyngeal cancer survivors (NPC) treated with intensity-modulated radiotherapy (IMRT). MATERIALS/METHODS: A cross-sectional cohort of NPC ≥4 years (y) following IMRT was assessed. Objective cognitive function was measured using the Montreal Cognitive Assessment (MoCA) and patient-reported memory was assessed with the MDASI-HN problems remembering item. Patient and family ratings of patients' neurobehavioral symptoms of apathy, disinhibition and executive dysfunction were assessed with the Frontal Sys...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 29, 2018 Category: Radiology Authors: McDowell LJ, Ringash J, Xu W, Chan B, Lu L, Waldron J, Rock K, So N, Huang SH, Giuliani M, Hope A, O'Sullivan B, Bratman SV, Cho J, Kim J, Jang R, Bayley A, Bernstein LJ Tags: Radiother Oncol Source Type: research

In reply to Keenan et al. Anatomic principles as the basis of target volume definition.
PMID: 30279048 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 29, 2018 Category: Radiology Authors: Eifel PJ, Klopp AH Tags: Radiother Oncol Source Type: research

Quantitative radiomics: Validating image textural features for oncological PET in lung cancer.
CONCLUSION: The use of image based textural features as a surrogate for tumoral phenotypic spatial heterogeneity could not be clearly validated. The association between the two is complex and a significant amount of uncertainty exist due to the introduction of incidental texture during image acquisition and reconstruction. PMID: 30279049 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 29, 2018 Category: Radiology Authors: Yang F, Young LA, Johnson PB Tags: Radiother Oncol Source Type: research

Quality of life changes after stereotactic ablative radiotherapy for liver metastases: A prospective cohort analysis.
Abstract PURPOSE: To report the changes in quality of life (QoL) after stereotactic ablative radiotherapy (SABR) in patients with liver metastases (LM). MATERIALS AND METHODS: A prospective cohort study was undertaken to measure the acute changes in QoL after SABR. Patients with 1-3 treated LM were eligible. Doses of 30-60 Gy in 3-5 fractions were delivered. Prospective QoL was measured using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaires, Core 15 for Palliative Care (EORTC QLQ-C15-PAL) and liver metastases (LM21), at baseline, 1st week and last day of treatmen...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 28, 2018 Category: Radiology Authors: Helou J, Thibault I, Chu W, Munoz-Schuffenegger P, Erler D, Rodrigues G, Warner A, Chan KKW, Chow E, Korol R, Davidson M, Chung HT Tags: Radiother Oncol Source Type: research