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Brachytherapy for high grade prostate cancer induces distinct changes in circulating CD4 and CD8 T cells - implications for systemic control
Radiother Oncol. 2024 Jan 2:110077. doi: 10.1016/j.radonc.2023.110077. Online ahead of print.ABSTRACTThis exploratory study is a follow up to our previous investigation of immune response in the circulation of high-grade Gleason 9 prostate cancer patients treated with EBRT+BT compared to EBRT alone. Notably, EBRT+BT demonstrates the potential to elicit an effect on CD4/CD8 ratio which may attributed to improved clinical response to therapy. Our findings show promise for leveraging circulating immune cells as predictive biomarkers for radiotherapy response.PMID:38176656 | DOI:10.1016/j.radonc.2023.110077 (Source: Radiothera...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 4, 2024 Category: Radiology Authors: H Wang L Mendez G Morton A Loblaw H T Chung P Cheung A Mesci V Escueta T N Petchiny X Huang S D White M Downes D Vesprini S K Liu Source Type: research

LUMINA: Using molecular biomarkers to guide decision making for breast radiotherapy
Radiother Oncol. 2023 Dec 30:110074. doi: 10.1016/j.radonc.2023.110074. Online ahead of print.ABSTRACTIn this opinion piece, we respond to comments about the LUMINA trial by Meattini and colleagues in the Journal. LUMINA was a prospective cohort study which evaluated the omission of radiotherapy after breast conserving surgery (BCS) in patients treated with endocrine therapy with low risk clinico-pathologic features and luminal A breast cancer. We address their areas of concern including the single cohort design that required careful patient selection, the relatively short follow-up period of 5 years, and the limited follo...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 1, 2024 Category: Radiology Authors: Timothy J Whelan Anthony Fyles Sameer Parpia Torsten Nielsen Mark N Levine Source Type: research

Oligometastatic sarcoma treated with Curative intent Ablative Radiotherapy (OSCAR): A multicenter study on behalf of AIRO (Italian association of Radiotherapy and clinical Oncology)
CONCLUSION: SABR is a safe and effective approach for the treatment of oligometastatic sarcoma. One out of 5 patients is free of progression at 2-years.PMID:38163485 | DOI:10.1016/j.radonc.2023.110078 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 1, 2024 Category: Radiology Authors: D Franceschini D Greto S Dicuonzo F Navarria M Federico M La Vecchia C Sangalli A Allajbej L Di Cristina R Mazzola A Pontoniero G Montesi P Navarria D Baldaccini E Clerici L Lo Faro C Franzese S Di Biase S Pergolizzi F Alongi M Bignardi I Fazio M Mascarin Source Type: research

Pulmonary interstitial lymphography: A prospective trial with potential impact on stereotactic ablative radiotherapy planning for early-stage lung cancer
Radiother Oncol. 2023 Dec 30;191:110079. doi: 10.1016/j.radonc.2023.110079. Online ahead of print.ABSTRACTThis prospective feasibility trial investigated pulmonary interstitial lymphography to identify thoracic primary nodal drainage (PND). A post-hoc analysis of nodal recurrences was compared with PND for patients with early-stage lung cancer; larger studies are needed to establish correlation. Exploratory PND-inclusive stereotactic ablative radiotherapy plans were assessed for dosimetric feasibility.PMID:38163486 | DOI:10.1016/j.radonc.2023.110079 (Source: Radiotherapy and Oncology : journal of the European Society for T...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 1, 2024 Category: Radiology Authors: Ryan B Ko Jonathan A Abelson Dominik Fleischmann John D Louie Gloria L Hwang Daniel Y Sze Emil Sch üler Kayla N Kielar Peter G Maxim Quynh-Thu Le Wendy H Hara Maximilian Diehn Nishita Kothary Billy W Loo Source Type: research

LUMINA: Using molecular biomarkers to guide decision making for breast radiotherapy
Radiother Oncol. 2023 Dec 30:110074. doi: 10.1016/j.radonc.2023.110074. Online ahead of print.ABSTRACTIn this opinion piece, we respond to comments about the LUMINA trial by Meattini and colleagues in the Journal. LUMINA was a prospective cohort study which evaluated the omission of radiotherapy after breast conserving surgery (BCS) in patients treated with endocrine therapy with low risk clinico-pathologic features and luminal A breast cancer. We address their areas of concern including the single cohort design that required careful patient selection, the relatively short follow-up period of 5 years, and the limited follo...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 1, 2024 Category: Radiology Authors: Timothy J Whelan Anthony Fyles Sameer Parpia Torsten Nielsen Mark N Levine Source Type: research

Oligometastatic Sarcoma treated with Curative intent Ablative Radiotherapy (OSCAR): a multicenter study on behalf of AIRO (Italian Association of Radiotherapy and clinical Oncology)
CONCLUSION SABR is a safe and effective approach for the treatment of oligometastatic sarcoma. One out of 5 patients is free of progression at 2-years.PMID:38163485 | DOI:10.1016/j.radonc.2023.110078 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 1, 2024 Category: Radiology Authors: D Franceschini D Greto S Dicuonzo F Navarria M Federico M La Vecchia C Sangalli A Allajbej L Di Cristina R Mazzola A Pontoniero G Montesi P Navarria D Baldaccini E Clerici L Lo Faro C Franzese S Di Biase S Pergolizzi F Alongi M Bignardi I Fazio M Mascarin Source Type: research

Pulmonary interstitial lymphography: A prospective trial with potential impact on stereotactic ablative radiotherapy planning for early-stage lung cancer
Radiother Oncol. 2023 Dec 30:110079. doi: 10.1016/j.radonc.2023.110079. Online ahead of print.ABSTRACTThis prospective feasibility trial investigated pulmonary interstitial lymphography to identify thoracic primary nodal drainage (PND). A post-hoc analysis of nodal recurrences was compared with PND for patients with early-stage lung cancer; larger studies are needed to establish correlation. Exploratory PND-inclusive stereotactic ablative radiotherapy plans were assessed for dosimetric feasibility.PMID:38163486 | DOI:10.1016/j.radonc.2023.110079 (Source: Radiotherapy and Oncology : journal of the European Society for Thera...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 1, 2024 Category: Radiology Authors: Ryan B Ko Jonathan A Abelson Dominik Fleischmann John D Louie Gloria L Hwang Daniel Y Sze Emil Sch üler Kayla N Kielar Peter G Maxim Quynh-Thu Le Wendy H Hara Maximilian Diehn Nishita Kothary Billy W Loo Source Type: research

LUMINA: Using molecular biomarkers to guide decision making for breast radiotherapy
Radiother Oncol. 2023 Dec 30:110074. doi: 10.1016/j.radonc.2023.110074. Online ahead of print.ABSTRACTIn this opinion piece, we respond to comments about the LUMINA trial by Meattini and colleagues in the Journal. LUMINA was a prospective cohort study which evaluated the omission of radiotherapy after breast conserving surgery (BCS) in patients treated with endocrine therapy with low risk clinico-pathologic features and luminal A breast cancer. We address their areas of concern including the single cohort design that required careful patient selection, the relatively short follow-up period of 5 years, and the limited follo...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 1, 2024 Category: Radiology Authors: Timothy J Whelan Anthony Fyles Sameer Parpia Torsten Nielsen Mark N Levine Source Type: research

Oligometastatic Sarcoma treated with Curative intent Ablative Radiotherapy (OSCAR): a multicenter study on behalf of AIRO (Italian Association of Radiotherapy and clinical Oncology)
CONCLUSION SABR is a safe and effective approach for the treatment of oligometastatic sarcoma. One out of 5 patients is free of progression at 2-years.PMID:38163485 | DOI:10.1016/j.radonc.2023.110078 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 1, 2024 Category: Radiology Authors: D Franceschini D Greto S Dicuonzo F Navarria M Federico M La Vecchia C Sangalli A Allajbej L Di Cristina R Mazzola A Pontoniero G Montesi P Navarria D Baldaccini E Clerici L Lo Faro C Franzese S Di Biase S Pergolizzi F Alongi M Bignardi I Fazio M Mascarin Source Type: research

Pulmonary interstitial lymphography: A prospective trial with potential impact on stereotactic ablative radiotherapy planning for early-stage lung cancer
Radiother Oncol. 2023 Dec 30:110079. doi: 10.1016/j.radonc.2023.110079. Online ahead of print.ABSTRACTThis prospective feasibility trial investigated pulmonary interstitial lymphography to identify thoracic primary nodal drainage (PND). A post-hoc analysis of nodal recurrences was compared with PND for patients with early-stage lung cancer; larger studies are needed to establish correlation. Exploratory PND-inclusive stereotactic ablative radiotherapy plans were assessed for dosimetric feasibility.PMID:38163486 | DOI:10.1016/j.radonc.2023.110079 (Source: Radiotherapy and Oncology : journal of the European Society for Thera...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 1, 2024 Category: Radiology Authors: Ryan B Ko Jonathan A Abelson Dominik Fleischmann John D Louie Gloria L Hwang Daniel Y Sze Emil Sch üler Kayla N Kielar Peter G Maxim Quynh-Thu Le Wendy H Hara Maximilian Diehn Nishita Kothary Billy W Loo Source Type: research

The Organization of Care in Pediatric Radiotherapy across SIOP Europe affiliated centers: A multicenter survey in the Framework of the 'Joint Action on Rare Cancers' project: Organization of care in pediatric radiotherapy across SIOPE
Conclusion This survey demonstrates the disparities in organization of pediatric radiotherapy departments between SIOPE-affiliated countries and centers within the same country. Investment is needed to reduce inequalities in pediatric radiotherapy care.PMID:38159681 | DOI:10.1016/j.radonc.2023.110075 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 30, 2023 Category: Radiology Authors: Geert O Janssens Beate Timmermann Anne Laprie Henry Mandeville Laetitia Padovani Cyrus Chargari Pamela Kearnsh Olga Kozhaeva Leila Kameric Anita Kienesberger Peter S N van Rossum Tom Boterberg Yolande Lievens Gilles Vassal Source Type: research

Clinical research for global needs of radiation oncology
Radiother Oncol. 2023 Dec 27:110076. doi: 10.1016/j.radonc.2023.110076. Online ahead of print.NO ABSTRACTPMID:38157941 | DOI:10.1016/j.radonc.2023.110076 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 29, 2023 Category: Radiology Authors: Michael Baumann Carol Bacchus Marianne C Aznar Rob P Coppes Eric Deutsch Dietmar Georg Karin Haustermans Peter Hoskin Mechthild Krause Eric F Lartigau Anne W M Lee Steffen L öck Birgitte V Offersen David I Thwaites Uulke A van der Heide Vincenzo Valentin Source Type: research

The long-term impact of irradiation on functional connectivity in brain circuits involved in memory processes after pediatric posterior fossa tumor
CONCLUSION: The results of this study highlight that irradiation has a long-term impact on brain connectivity in brain circuits involved in memory after pediatric PFT with a specific radiation-dose effect in supratentorial structures.PMID:38145791 | DOI:10.1016/j.radonc.2023.110073 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 25, 2023 Category: Radiology Authors: Elo ïse Baudou Patrice Peran Fatima Tensaouti Germain Arribarat J érémie Pariente Nicolas Courbieres Lisa Pollidoro Anne-Isabelle Bertozzi Marion Gambart Annick Sevely Margaux Roques Anne Ducassou J érémy Danna Jessica Tallet Christelle Dufour Yves C Source Type: research

The long-term impact of irradiation on functional connectivity in brain circuits involved in memory processes after pediatric posterior fossa tumor
CONCLUSION: The results of this study highlight that irradiation has a long-term impact on brain connectivity in brain circuits involved in memory after pediatric PFT with a specific radiation-dose effect in supratentorial structures.PMID:38145791 | DOI:10.1016/j.radonc.2023.110073 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 25, 2023 Category: Radiology Authors: Elo ïse Baudou Patrice Peran Fatima Tensaouti Germain Arribarat J érémie Pariente Nicolas Courbieres Lisa Pollidoro Anne-Isabelle Bertozzi Marion Gambart Annick Sevely Margaux Roques Anne Ducassou J érémy Danna Jessica Tallet Christelle Dufour Yves C Source Type: research

The long-term impact of irradiation on functional connectivity in brain circuits involved in memory processes after pediatric posterior fossa tumor
CONCLUSION: The results of this study highlight that irradiation has a long-term impact on brain connectivity in brain circuits involved in memory after pediatric PFT with a specific radiation-dose effect in supratentorial structures.PMID:38145791 | DOI:10.1016/j.radonc.2023.110073 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 25, 2023 Category: Radiology Authors: Elo ïse Baudou Patrice Peran Fatima Tensaouti Germain Arribarat J érémie Pariente Nicolas Courbieres Lisa Pollidoro Anne-Isabelle Bertozzi Marion Gambart Annick Sevely Margaux Roques Anne Ducassou J érémy Danna Jessica Tallet Christelle Dufour Yves C Source Type: research