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The safety and effectiveness of stereotactic body radiotherapy for central versus ultracentral lung tumors.
CONCLUSIONS: There were no significant differences in OS, LF, or grade ≥3 toxicity between patients with central and ultracentral lung tumors. Although these results indicate that SBRT for ultracentral tumors may be safe, caution should be applied in selecting and treating these patients until the completion of large prospective trials. PMID: 30049454 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 23, 2018 Category: Radiology Authors: Chang JH, Poon I, Erler D, Zhang L, Cheung P Tags: Radiother Oncol Source Type: research

Anatomical change during radiotherapy for head and neck cancer, and its effect on delivered dose to the spinal cord.
Abstract BACKGROUND AND PURPOSE: The impact of weight loss and anatomical change during head and neck (H&N) radiotherapy on spinal cord dosimetry is poorly understood, limiting evidence-based adaptive management strategies. MATERIALS AND METHODS: 133 H&N patients treated with daily mega-voltage CT image-guidance (MVCT-IG) on TomoTherapy, were selected. Elastix software was used to deform planning scan SC contours to MVCT-IG scans, and accumulate dose. Planned (DP) and delivered (DA) spinal cord D2% (SCD2%) were compared. Univariate relationships between neck irradiation strategy (unilateral vs bilater...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 23, 2018 Category: Radiology Authors: Noble DJ, Yeap PL, Seah SYK, Harrison K, Shelley LEA, Romanchikova M, Bates AM, Zheng Y, Barnett GC, Benson RJ, Jefferies SJ, Thomas SJ, Jena R, Burnet NG Tags: Radiother Oncol Source Type: research

Clustered DNA damage concentrated in particle trajectories causes persistent large-scale rearrangements in chromatin architecture.
CONCLUSION: Clustered damage concentrated in particle trajectories causes persistent rearrangements in chromatin architecture, which may affect structural and functional organization of cell nuclei. PMID: 30049456 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 23, 2018 Category: Radiology Authors: Timm S, Lorat Y, Jakob B, Taucher-Scholz G, Rübe CE Tags: Radiother Oncol Source Type: research

Response to Oymak et al.
PMID: 30041819 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 21, 2018 Category: Radiology Authors: Veiga C, McClelland JR, Landau D Tags: Radiother Oncol Source Type: research

Necessity of adjuvant concurrent chemo-radiotherapy in D2-resected LN-positive gastric cancer.
Abstract BACKGROUND AND PURPOSE: To investigate the role of adjuvant concurrent chemo-radiotherapy (CCRT) by analyzing the outcomes of adjuvant CCRT versus chemotherapy alone (CA) in patients with D2-resected gastric cancer with lymph node (LN) metastasis. MATERIALS AND METHODS: Patients with gastric cancer from the institutional registry who underwent curative D2 and R0 resection from December 2004 to January 2013 followed by adjuvant CCRT or CA and demonstrated pathologically confirmed LN metastasis without distant metastasis were included in the study. RESULTS: A total of 1633 patients were included (...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 20, 2018 Category: Radiology Authors: Yu JI, Lim DH, Lee J, Kang WK, Park SH, Park JO, Park YS, Lim HY, Kim ST, Lee SJ, Kim S, Sohn TS, Lee JH, An JY, Choi MG, Bae JM, Kim HS, Ahn S Tags: Radiother Oncol Source Type: research

Radiotherapy for recurrent prostate cancer: 2018 Recommendations of the Australian and New Zealand Radiation Oncology Genito-Urinary group.
Abstract The management of patients with biochemical, local, nodal, or oligometastatic relapsed prostate cancer has become more challenging and controversial. Novel imaging modalities designed to detect recurrence are increasingly used, particularly PSMA-PET scans in Australia, New Zealand and some European countries. Imaging techniques such as MRI and PET scans using other prostate cancer-specific tracers are also being utilised across the world. The optimal timing for commencing salvage treatment, and the role of local and/or systemic therapies remains controversial. Through surveys of the membership, the Austra...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 20, 2018 Category: Radiology Authors: Lieng H, Hayden AJ, Christie DRH, Davis BJ, Eade TN, Emmett L, Holt T, Hruby G, Pryor D, Shakespeare TP, Sidhom M, Skala M, Wiltshire K, Yaxley J, Kneebone A Tags: Radiother Oncol Source Type: research

Impact of modern-day axillary treatment on patient reported arm morbidity and physical functioning in breast cancer patients.
CONCLUSION: Of all axillary management strategies, ALND plus AxRT is associated with worst patient-reported outcomes. AxRT resulted in less arm morbidity compared to ALND. Selective radiotherapy treatment of the axilla, i.e. radiotherapy of levels I-II only instead of levels I-IV, did not lead to clinically relevant reduced arm morbidity. PMID: 30033384 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 19, 2018 Category: Radiology Authors: Gregorowitsch ML, Verkooijen HM, Houweling A, Fuhler N, Koelemij R, Schoenmaeckers EJP, Sier MF, Ernst MF, Witkamp AJ, Van Dalen T, Young-Afat DA, van den Bongard DHJG, UMBRELLA study group Tags: Radiother Oncol Source Type: research

Development and validation of NTCP models for acute side-effects resulting from proton beam therapy of brain tumours.
CONCLUSION: We developed and successfully validated NTCP models for scalp erythema and alopecia in primary brain tumour patients treated with PBT. PMID: 30033385 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 19, 2018 Category: Radiology Authors: Dutz A, Lühr A, Agolli L, Troost EGC, Krause M, Baumann M, Vermeren X, Geismar D, Schapira EF, Bussière M, Daly JE, Bussière MR, Timmermann B, Shih HA, Löck S Tags: Radiother Oncol Source Type: research

Intra-breath-hold residual motion of image-guided DIBH liver-SBRT: An estimation by ultrasound-based monitoring correlated with diaphragm position in CBCT.
CONCLUSION: Soft-tissue monitoring with ultrasound is a fast real-time method without additional radiation exposure. Computer-controlled DIBH has a residual motion of 95% which is in line with the published intra-breath-hold-precision. Larger intrafractional deviations can be avoided if the beam is stopped at an US-defined threshold. PMID: 30033386 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 19, 2018 Category: Radiology Authors: Vogel L, Sihono DSK, Weiss C, Lohr F, Stieler F, Wertz H, von Swietochowski S, Simeonova-Chergou A, Wenz F, Blessing M, Boda-Heggemann J Tags: Radiother Oncol Source Type: research

Stereotactic body radiation therapy versus conventionally fractionated radiation therapy for early stage non-small cell lung cancer.
Abstract PURPOSE: To date, no published randomized trials have shown stereotactic body radiation therapy (SBRT) to offer superior outcomes to conventionally fractionated radiation therapy (CFRT) for early-stage non-small cell lung cancer (NSCLC). The largest study to date, this investigation of a contemporary national database sought to evaluate practice patterns and survival between CFRT and SBRT. METHODS: The National Cancer Database was queried (2004-2015) for histologically-confirmed cT1-2aN0M0 NSCLC undergoing definitive CFRT or SBRT. Multivariable logistic regression ascertained factors associated with ...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 18, 2018 Category: Radiology Authors: Haque W, Verma V, Polamraju P, Farach A, Butler EB, Teh BS Tags: Radiother Oncol Source Type: research

Responding to Veiga et al. 'Long term radiological features of radiation-induced lung damage'.
PMID: 30021696 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 16, 2018 Category: Radiology Authors: Oymak E, Yildirim BA, Guler OC, Onal C Tags: Radiother Oncol Source Type: research

Long term outcome of skull-base chondrosarcoma patients treated with high-dose proton therapy with or without conventional radiation therapy.
CONCLUSIONS: The outcome of skull-base ChSa patients treated with high-dose protons with or without photons is excellent, particularly for patients with small tumors with no optic pathway compression. Treatment failure was however associated with a significantly increased risk of death. PMID: 30021697 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 16, 2018 Category: Radiology Authors: Weber DC, Murray F, Combescure C, Calugaru V, Alapetite C, Albertini F, Bolle S, Goudjil F, Pica A, Walser M, Mammar H, Bachtiary B, Lomax T, Noël G, Dendale R, Feuvret L Tags: Radiother Oncol Source Type: research

Is there a role for salvage re-irradiation in pediatric patients with locoregional recurrent rhabdomyosarcoma? Clinical outcomes from a multi-institutional cohort.
CONCLUSION: Salvage re-irradiation appears tolerable with acceptable morbidity and may reduce the risk of subsequent LR as a component of death in patients with LR RMS. PMID: 30017104 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 14, 2018 Category: Radiology Authors: Wakefield DV, Eaton BR, Dove APH, Hsu CY, Merchant TE, Pappo A, Davidoff AM, Esiashvili N, Krasin MJ, Lucas JT Tags: Radiother Oncol Source Type: research

Inhomogeneous tumor dose distribution provides better local control than homogeneous distribution in stereotactic radiotherapy for brain metastases.
CONCLUSION: SRT delivered with inhomogeneous dose distribution resulted in better LC and a lower risk of RN compared to homogeneous distribution. PMID: 30017105 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 14, 2018 Category: Radiology Authors: Lucia F, Key S, Dissaux G, Goasduff G, Lucia AS, Ollivier L, Pradier O, Schick U Tags: Radiother Oncol Source Type: research

The impact of margin reduction on outcome and toxicity in head and neck cancer patients treated with image-guided volumetric modulated arc therapy (VMAT).
CONCLUSION: Reducing the CTV-PTV margin from 5 to 3 mm combined with daily CBCT-guided VMAT reduced the severity, frequency, and duration of radiation-related toxicity without jeopardizing outcome. PMID: 30005953 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 10, 2018 Category: Radiology Authors: Navran A, Heemsbergen W, Janssen T, Hamming-Vrieze O, Jonker M, Zuur C, Verheij M, Remeijer P, Sonke JJ, van den Brekel M, Al-Mamgani A Tags: Radiother Oncol Source Type: research

Tumor to cervical spinal cord standardized uptake ratio (SUR) improves the reproducibility of 18F-FDG-PET based tumor segmentation in head and neck squamous cell carcinoma in a multicenter setting.
CONCLUSION: The use of the tumor to cervical spinal cord SUR instead of SUV improves the reproducibility of a model to determine the MTV on FDG-PET/CT in a multicenter setting. This study indicates that SUR may be preferred over SUV based approaches. PMID: 30005954 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 10, 2018 Category: Radiology Authors: van den Bosch S, Dijkema T, Philippens MEP, Terhaard CHJ, Hoebers FJP, Kaanders JHAM, Oyen WJG Tags: Radiother Oncol Source Type: research

NHL-ChirEx: An interprofessional cross-border education initiative in the Greater Region with a focus on radiation morbidity and patient safety.
Abstract NHL-ChirEx is an interprofessional cross-border education project that addresses the potential excess of radiation induced morbidity throughout the radiation planning and treatment process. NHL-ChirEx is supported by ESTRO and the University of the Greater Region and has been recently approved and funded under INTERREG VA Programme. PMID: 30001933 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 10, 2018 Category: Radiology Authors: Vogin G, Fleckenstein J, Servotte JC, Nickers P, Ebersberger A, Mohammad F, Bragard I, Coucke P, Untereiner M, Peiffert D, Braun M, Greater Region radiation oncology consortium Tags: Radiother Oncol Source Type: research

Radiotherapy in Asia: Making progress step by step.
PMID: 30001934 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 10, 2018 Category: Radiology Authors: Eriksen JG Tags: Radiother Oncol Source Type: research

Union of light ion therapy centers in Europe (ULICE EC FP7) - Objectives and achievements of joint research activities.
The objectives and main achievements are summarized. References to either publications or open access deliverables from the five year project work are given. Overall, carbon ion radiotherapy is still not as mature as photon or proton radiotherapy. Achieved results and open questions are reflected and discussed in the context of the current status of carbon ion therapy and particle and photon beam therapy. Most research topics covered in the ULICE JRA pillar are topical. Future research activities can build upon these ULICE results. Together with the continuous increase in the number of particle therapy centers in the last ...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 9, 2018 Category: Radiology Authors: Pötter R, Balosso J, Baumann M, Bert C, Davies J, Enghardt W, Fossati P, Harris S, Jones B, Krämer M, Mayer R, Mock U, Pullia M, Schreiner T, Dosanjh M, Debus J, Orecchia R, Georg D, ULICE Collaborative Research Group Tags: Radiother Oncol Source Type: research

Stereotactic body radiotherapy for colorectal cancer liver metastases: A systematic review.
CONCLUSION: SBRT for liver oligometastases is an effective option for patients with advanced CRC, with encouraging local control and survival. However, a definitive validation in large randomised studies is required, due to the retrospective or non-randomised nature of the included studies and the limitations of series with different doses/schedules of treatment. PMID: 29997034 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 9, 2018 Category: Radiology Authors: Petrelli F, Comito T, Barni S, Pancera G, Scorsetti M, Ghidini A, SBRT for CRC liver metastases Tags: Radiother Oncol Source Type: research

Impact of radiotherapy underutilisation measured by survival shortfall, years of potential life lost and disability-adjusted life years lost in New South Wales, Australia.
CONCLUSION: This study illustrates the value of considering different mortality statistics, which include measures of the burden of cancer deaths on both the population and patients. PMID: 29983259 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 5, 2018 Category: Radiology Authors: Batumalai V, Shafiq J, Gabriel G, Hanna TP, Delaney GP, Barton M Tags: Radiother Oncol Source Type: research

Comparison of SUVmax and SUVpeak based segmentation to determine primary lung tumour volume on FDG PET-CT correlated with pathology data.
CONCLUSION: No benefit was shown on clinical data for the SUVpeak based segmentation method over a SUVmax based one. Both methods can be used to determine the tumour volumes in resected NSCLC tumours. PMID: 29983260 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 5, 2018 Category: Radiology Authors: Mercieca S, Belderbos J, van Loon J, Gilhuijs K, Julyan P, van Herk M Tags: Radiother Oncol Source Type: research

Predictors for poor cosmetic outcome in patients with early stage breast cancer treated with breast conserving therapy: Results of the Young boost trial.
CONCLUSION: Important risk factors for worse CO were the use of a photon boost instead of an electron boost, a high boost dose, cosmesis at baseline, adjuvant chemotherapy and boost volume. These results can be used to define strategies aimed at improving CO. PMID: 29980320 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 3, 2018 Category: Radiology Authors: Brouwers PJAM, van Werkhoven E, Bartelink H, Fourquet A, Lemanski C, van Loon J, Maduro JH, Russell NS, Scheijmans LJEE, Schinagl DAX, Westenberg AH, Poortmans P, Boersma LJ, Young Boost Trial research group Tags: Radiother Oncol Source Type: research

Fully automated, multi-criterial planning for Volumetric Modulated Arc Therapy - An international multi-center validation for prostate cancer.
Abstract BACKGROUND AND PURPOSE: Reported plan quality improvements with autoplanning of radiotherapy of the prostate and seminal vesicles are poor. A system for automated multi-criterial planning has been validated for this treatment in a large international multi-center study. The system is configured with training plans using a mechanism that strives for quality improvements relative to those plans. MATERIAL AND METHODS: Each of the four participating centers included thirty manually generated clinical Volumetric Modulated Arc Therapy prostate plans (manVMAT). Ten plans were used for autoplanning training....
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 30, 2018 Category: Radiology Authors: Heijmen B, Voet P, Fransen D, Penninkhof J, Milder M, Akhiat H, Bonomo P, Casati M, Georg D, Goldner G, Henry A, Lilley J, Lohr F, Marrazzo L, Pallotta S, Pellegrini R, Seppenwoolde Y, Simontacchi G, Steil V, Stieler F, Wilson S, Breedveld S Tags: Radiother Oncol Source Type: research

Radiotherapy dose-volume parameters predict videofluoroscopy-detected dysphagia per DIGEST after IMRT for oropharyngeal cancer: Results of a prospective registry.
CONCLUSION: The findings from this prospective longitudinal registry validate prior observations that dose to submental musculature predicts for increased burden of dysphagia after oropharyngeal IMRT. Findings also support dichotomization of DIGEST grade ≥2 as a dose-dependent split for use as an endpoint in trials or predictive dose-response analysis of videofluoroscopy results. PMID: 29961581 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 28, 2018 Category: Radiology Authors: Kamal M, Mohamed ASR, Volpe S, Zaveri J, Barrow MP, Gunn GB, Lai SY, Ferrarotto R, Lewin JS, Rosenthal DI, Jethanandani A, Meheissen MAM, Mulder SL, Cardenas CE, Fuller CD, Hutcheson KA, MD Anderson Head, Neck Cancer Symptom Working Group Tags: Radiother Oncol Source Type: research

Response to Spartalis et al.
PMID: 29961582 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 28, 2018 Category: Radiology Authors: Jumeau R, Ozsahin M, Moeckli R, Pruvot E, Bourhis J Tags: Radiother Oncol Source Type: research

Adjuvant postoperative high-dose radiotherapy for atypical and malignant meningioma: A phase-II parallel non-randomized and observation study (EORTC 22042-26042).
CONCLUSIONS: These data show that 3-year PFS for WHO grade II meningioma patients undergoing a complete resection (Simpson I-III) is superior to 70% when treated with high-dose (60 Gy) RT. PMID: 29960684 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 27, 2018 Category: Radiology Authors: Weber DC, Ares C, Villa S, Peerdeman SM, Renard L, Baumert BG, Lucas A, Veninga T, Pica A, Jefferies S, Ricardi U, Miralbell R, Stelmes JJ, Liu Y, Collette L, Collette S Tags: Radiother Oncol Source Type: research

Stereotactic radiosurgery and immunotherapy in melanoma brain metastases: Patterns of care and treatment outcomes.
Abstract PURPOSE: Preclinical studies have suggested that radiation therapy (RT) enhances antitumor immune response and can act synergistically when administered with immunotherapy. However, this effect in melanoma brain metastasis is not well studied. We aim to explore the clinical effect of combining RT and immunotherapy in patients with melanoma brain metastasis (MBM). MATERIALS AND METHODS: Patients with MBM between 2011 and 2013 were obtained from the National Cancer Database. Patients who did not have identifiable sites of metastasis and who did not receive RT for the treatment of their MBM were exclude...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 27, 2018 Category: Radiology Authors: Gabani P, Fischer-Valuck BW, Johanns TM, Hernandez-Aya LF, Keller JW, Rich KM, Kim AH, Dunn GP, Robinson CG, Chicoine MR, Huang J, Abraham CD Tags: Radiother Oncol Source Type: research

Parotid gland fat related Magnetic Resonance image biomarkers improve prediction of late radiation-induced xerostomia.
CONCLUSION: Pre-treatment MR-IBMs were associated to radiation-induced xerostomia, which supported the hypothesis that the amount of predisposed fat within the parotid glands is associated with Xer12m. In addition, xerostomia prediction was improved with MR-IBMs compared to the reference model. PMID: 29958772 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 26, 2018 Category: Radiology Authors: van Dijk LV, Thor M, Steenbakkers RJHM, Apte A, Zhai TT, Borra R, Noordzij W, Estilo C, Lee N, Langendijk JA, Deasy JO, Sijtsema NM Tags: Radiother Oncol Source Type: research

A global Unified Dosimetry Index (gUDI) to evaluate simultaneous integrated boost radiotherapy plans in prostate cancer.
CONCLUSION: gUDI score can be a useful tool to quantify treatment plans quality also when volumes with different dose-prescription are treated. PMID: 29945720 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 23, 2018 Category: Radiology Authors: Mambretti M, Romanò C, Marvaso G, Comi S, Cambria R, Ciardo D, Emiro F, Fodor C, Zerini D, Riva G, Petralia G, De Cobelli O, Orecchia R, Cattani F, Jereczek-Fossa BA Tags: Radiother Oncol Source Type: research

Statistical motion modelling for robust evaluation of clinically delivered accumulated dose distributions after curative radiotherapy of locally advanced prostate cancer.
CONCLUSION: The planned dose escalation was not received by more than half-of-the patients. Robustness of the prostate target (CTV67.5) should therefore be better prioritized in these patients given the low toxicity profile. Estimates of delivered dose were less conservative for dose-accumulation due to interaction of random organ motion with the dose matrix. PMID: 29941300 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 22, 2018 Category: Radiology Authors: Hysing LB, Ekanger C, Zolnay Á, Helle SI, Rasi M, Heijmen BJM, Sikora M, Söhn M, Muren LP, Thörnqvist S Tags: Radiother Oncol Source Type: research

Proton therapy for pediatric malignancies: Fact, figures and costs. A joint consensus statement from the pediatric subcommittee of PTCOG, PROS and EPTN.
Abstract Radiotherapy plays an important role in the management of childhood cancer, with the primary aim of achieving the highest likelihood of cure with the lowest risk of radiation-induced morbidity. Proton therapy (PT) provides an undisputable advantage by reducing the radiation 'bath' dose delivered to non-target structures/volume while optimally covering the tumor with tumoricidal dose. This treatment modality comes, however, with an additional costs compared to conventional radiotherapy that could put substantial financial pressure to the health care systems with societal implications. In this review we ass...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 21, 2018 Category: Radiology Authors: Weber DC, Habrand JL, Hoppe BS, Hill Kayser C, Laack NN, Langendijk JA, MacDonald SM, McGovern SL, Pater L, Perentesis JP, Thariat J, Timmerman B, Yock TI, Mahajan A Tags: Radiother Oncol Source Type: research

Harnessing drug/radiation interaction through daily routine practice: Leverage medical and methodological point of view (MORSE 02-17 study).
CONCLUSION: Drug-radiation interaction remains a subject of major interest, not only for conventional anticancer drugs, but also for NACTs. New trial designs are thus required. PMID: 29937210 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 21, 2018 Category: Radiology Authors: Vallard A, Rancoule C, Espenel S, Garcia MA, Langrand-Escure J, He MY, Ben Mrad M, El Meddeb Hamrouni A, Ouni S, Trone JC, Rehailia-Blanchard A, Guillaume E, Vial N, Riocreux C, Guy JB, Magné N Tags: Radiother Oncol Source Type: research

Long term patient reported swallowing function following chemoradiotherapy for oropharyngeal carcinoma.
Abstract BACKGROUND AND PURPOSE: Limited data are available to inform on long term swallowing outcomes following concurrent chemoradiotherapy for oropharyngeal carcinoma. The aims of this study are to determine long term patient-reported swallowing outcomes across two large UK centres in routine clinical practice and identify associated factors. MATERIAL AND METHODS: All patients treated for oropharyngeal squamous cell carcinoma with concurrent chemoradiotherapy, and irradiation of the bilateral neck, between 2011 and 2013 were identified. Those requiring therapeutic enteral feeding prior to treatment, or hav...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 21, 2018 Category: Radiology Authors: Dixon L, Ramasamy S, Cardale K, Dyker K, Garcez K, Lee LW, McPartlin A, Murray P, Sen M, Slevin N, Sykes A, Prestwich R, Thomson D Tags: Radiother Oncol Source Type: research

Survival gain with re-Op/RT for recurred high-grade gliomas depends upon risk groups.
CONCLUSION: Re-RT after re-Op was tolerable with a cumulative median EQD2 of 99.3 Gy and resulted in clear benefit in PFS and marginal gain in OS. Survival gain with re-Op/RT was more prominent in patients with two or more risk factors (age ≥50, WHO pathologic grade IV, unmethylated MGMT promoter), and needs to be validated. PMID: 29937212 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 21, 2018 Category: Radiology Authors: Chun SJ, Park SH, Park CK, Kim JW, Kim TM, Choi SH, Lee ST, Kim IH Tags: Radiother Oncol Source Type: research

Safety concerns regarding ablative radiotherapy for ventricular tachycardia.
PMID: 29937213 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 21, 2018 Category: Radiology Authors: Spartalis M, Spartalis E, Athanasiou A, Nikiteas N Tags: Radiother Oncol Source Type: research

Determinants for local tumour control probability after radiotherapy of anal cancer.
CONCLUSIONS: Our results basically support current guidelines recommending: (1) lower RT dose in small tumours (
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 19, 2018 Category: Radiology Authors: Johnsson A, Leon O, Gunnlaugsson A, Nilsson P, Höglund P Tags: Radiother Oncol Source Type: research

Estimating the need for palliative radiotherapy for non-small cell lung cancer: A criterion-based benchmarking approach.
CONCLUSIONS: Approximately 56% of patients who die of NSCLC in Ontario need PRT, but many are never treated. PMID: 29934108 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 19, 2018 Category: Radiology Authors: Jin CJ, Kong W, Mackillop WJ Tags: Radiother Oncol Source Type: research

Inverse planning and inverse implanting for breast interstitial brachytherapy. Introducing a new anatomy specific breast interstitial template (ASBIT).
Abstract An innovative template, based on thoracic cage surface reconstructions for breast interstitial brachytherapy was developed. Hybrid-inverse-planning-optimisation-based implantations and brachytherapy plans, using three custom anthropomorphic breast phantoms, were utilised for its validation. A user independent, inverse planning and inverse implanting technique is proposed. PMID: 29934109 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 19, 2018 Category: Radiology Authors: Karagiannis E, Leczynski A, Tselis N, Psanis E, Steckenreiter O, Milickovic N, Bon D, Strouthos I, Ferentinos K, Hass P, Gademann G, Baltas D, Zamboglou N Tags: Radiother Oncol Source Type: research

Cardiac mortality in limited-stage small cell lung cancer.
CONCLUSIONS: Although causation between radiotherapy and CSM in LS-SCLC cannot be stated based on these data, we encourage clinical attentiveness to cardiac-sparing radiotherapy for LS-SCLC, along with further investigation evaluating dosimetric correlates for cardiotoxicity. PMID: 29934110 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 19, 2018 Category: Radiology Authors: Verma V, Fakhreddine MH, Haque W, Butler EB, Teh BS, Simone CB Tags: Radiother Oncol Source Type: research

Sensitization of prostate cancer to radiation therapy: Molecules and pathways to target.
This article focuses on the recent findings about molecules and pathways that potentially can be targeted to sensitize prostate cancer cells to ionizing radiation, thereby achieving an improved therapeutic outcome. PMID: 29929859 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 18, 2018 Category: Radiology Authors: Yao M, Rogers L, Suchowerska N, Choe D, Al-Dabbas MA, Narula RS, Lyons JG, Sved P, Li Z, Dong Q Tags: Radiother Oncol Source Type: research

Prospective evaluation of acute toxicity and patient reported outcomes in anal cancer and plan optimization.
CONCLUSIONS: The high incidence of PRO scores and weak agreement to CTCAE suggest that PROs are important tools complementary to CTCAE in evaluating patient symptoms during and after CRT. Proton therapy has the potential to lower radiation doses to most organs at risk. PMID: 29929860 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 18, 2018 Category: Radiology Authors: Kronborg C, Serup-Hansen E, Lefevre A, Wilken EE, Petersen JB, Hansen J, Schouboe A, Nyvang L, Spindler KG Tags: Radiother Oncol Source Type: research

Can clinicopathological parameters predict for lymph node metastases in ypT0-2 rectal carcinoma? Results of the CAO/ARO/AIO-94 and CAO/ARO/AIO-04 phase 3 trials.
CONCLUSION: Advanced ypT-stage, lymphatic invasion and RTD ≥10 mm were prognostic factors for LNM in patients ypT0-2 rectal carcinoma treated with CRT and surgery within both phase 3 trials. The high incidence of LNM in the ypT1-2 group needs to be taken into consideration in the context of oncological safety and indicate that LE should be advocated with great caution in this patient subgroup. The prognostic pathological factor identified here could help guide decision of LE vs TME after standard CRT. PMID: 29929861 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European S...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 18, 2018 Category: Radiology Authors: von den Grün JM, Hartmann A, Fietkau R, Ghadimi M, Liersch T, Hohenberger W, Weitz J, Sauer R, Wittekind C, Ströbel P, Rödel C, Fokas E, German Rectal Cancer Study Group Tags: Radiother Oncol Source Type: research

Changing the global radiation therapy paradigm.
PMID: 29921460 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 16, 2018 Category: Radiology Authors: Pistenmaa DA, Dosanjh M, Amaldi U, Jaffray D, Zubizarreta E, Holt K, Lievens Y, Pipman Y, Coleman CN, Workshop Participants Tags: Radiother Oncol Source Type: research

Clinical feasibility and positional stability of an implanted wired transmitter in a novel electromagnetic positioning system for prostate cancer radiotherapy.
ndblom J Abstract PURPOSE: Three aspects of the RayPilot real-time tracking system were investigated: (1) feasibility of the transmitter with respect to implantation and explantation procedures, (2) user and patients' experiences and (3) quantification of the transmitter positional stability in relation to fiducial markers. METHODS AND MATERIALS: Ten prostate cancer patients scheduled for radiotherapy received transmitter implantation in the prostate, concomitantly with fiducial markers. Transmitter and marker positions were assessed in 3D by orthogonal kV-imaging at daily treatment setup in eight patients. ...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 16, 2018 Category: Radiology Authors: Braide K, Lindencrona U, Welinder K, Götstedt J, Ståhl I, Pettersson N, Kindblom J Tags: Radiother Oncol Source Type: research

Long-term risks of secondary cancer for various whole and partial breast irradiation techniques.
CONCLUSIONS: APBI reduces the risk of secondary cancer 2-4 fold compared to WBI. These techniques are well suited for long-living early stage breast cancer patients. HDR brachytherapy and 3D-conformal APBI achieve mean lung doses between 1 and 1.5 Gy, which could serve as reference. PMID: 29914648 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 15, 2018 Category: Radiology Authors: Hoekstra N, Fleury E, Merino Lara TR, van der Baan P, Bahnerth A, Struik G, Hoogeman M, Pignol JP Tags: Radiother Oncol Source Type: research

Toward A variable RBE for proton beam therapy.
Abstract In the clinic, proton beam therapy (PBT) is based on the use of a generic relative biological effectiveness (RBE) of 1.1 compared to photons in human cancers and normal tissues. However, the experimental basis for this RBE lacks any significant number of representative tumor models and clinically relevant endpoints for dose-limiting organs at risk. It is now increasingly appreciated that much of the variations of treatment responses in cancers are due to inter-tumoral genomic heterogeneity. Indeed, recently it has been shown that defects in certain DNA repair pathways, which are found in subsets of many c...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 14, 2018 Category: Radiology Authors: Willers H, Allen A, Grosshans D, McMahon SJ, von Neubeck C, Wiese C, Vikram B Tags: Radiother Oncol Source Type: research

An overview on personalisation of radiotherapy prescriptions in locally advanced non-small cell lung cancer: Are we there yet?
Abstract Standard of care radiotherapy in LA-NSCLC is 60-66 Gy in 30-33 fractions. However outcomes for these patients are poor with 5-year survival in the range of 10-20%. Randomised controlled trials have shown that dose escalation in a linear fashion does not improve outcomes for all patients, thus there is a need to tailor the prescription to the individual patient. This review assesses the strategies published to personalise the radiation therapy dose prescription in LA-NSCLC. A systematic and scoping search of the literature was performed to identify studies that met the inclusion criteria. 19 relevant stu...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 13, 2018 Category: Radiology Authors: Barrett S, Hanna GG, Marignol L Tags: Radiother Oncol Source Type: research

Hematologic variables associated with brain failure in patients with small-cell lung cancer.
Abstract BACKGROUND AND PURPOSE: We sought factors associated with the development of brain metastases after treatment of small cell lung cancer (SCLC) in patients without brain involvement at diagnosis. METHODS: We analyzed 293 patients with SCLC without brain metastases who received chemotherapy, thoracic radiation therapy (TRT), or both in 2001-2015. Pretreatment hematologic markers (platelet count, neutrophil count, lymphocyte count, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and lactate dehydrogenase) and other clinical characteristics were evaluated for correlation with brain metastas...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 12, 2018 Category: Radiology Authors: Suzuki R, Wei X, Allen PK, Welsh JW, Komaki R, Lin SH Tags: Radiother Oncol Source Type: research

Artificial intelligence in radiation oncology: A specialty-wide disruptive transformation?
Abstract Artificial intelligence (AI) is emerging as a technology with the power to transform established industries, and with applications from automated manufacturing to advertising and facial recognition to fully autonomous transportation. Advances in each of these domains have led some to call AI the "fourth" industrial revolution [1]. In healthcare, AI is emerging as both a productive and disruptive force across many disciplines. This is perhaps most evident in Diagnostic Radiology and Pathology, specialties largely built around the processing and complex interpretation of medical images, where the ...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 12, 2018 Category: Radiology Authors: Thompson RF, Valdes G, Fuller CD, Carpenter CM, Morin O, Aneja S, Lindsay WD, Aerts HJWL, Agrimson B, Deville C, Rosenthal SA, Yu JB, Thomas CR Tags: Radiother Oncol Source Type: research