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Clinical outcomes of patients with limited brain metastases treated with hypofractionated (5 ×6Gy) conformal radiotherapy.
Clinical outcomes of patients with limited brain metastases treated with hypofractionated (5×6Gy) conformal radiotherapy. Radiother Oncol. 2017 Apr 05;: Authors: Lockney NA, Wang DG, Gutin PH, Brennan C, Tabar V, Ballangrud A, Pei X, Chan TA, Yamada Y, Yang TJ, Beal K Abstract BACKGROUND AND PURPOSE: Hypofractionated conformal radiotherapy (hfCRT) is used for larger brain metastases or metastases near critical structures. We investigated hfCRT outcomes for newly diagnosed brain metastases. MATERIALS AND METHODS: We identified 195 patients with 1-3 brain metastases who underwent 5×6Gy ...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 5, 2017 Category: Radiology Authors: Lockney NA, Wang DG, Gutin PH, Brennan C, Tabar V, Ballangrud A, Pei X, Chan TA, Yamada Y, Yang TJ, Beal K Tags: Radiother Oncol Source Type: research

Structure-based deformable image registration: Added value for dose accumulation of external beam radiotherapy and brachytherapy in cervical cancer.
Abstract BACKGROUND AND PURPOSE: Structure-based deformable image registration (DIR) can be used to calculate accumulated brachytherapy (BT) and external-beam radiation therapy (EBRT) dose-volume histogram (DVH) parameters in cervical cancer. Since direct parameter addition does not take dose non-uniformity into account, the added value of DIR over addition methods was investigated for bladder and rectum. MATERIALS AND METHODS: For twelve patients (EBRT: 46Gy, EBRT+BT: D90 85-90GyEQD2 in equivalent dose in 2Gy fractions) the EBRT planning CT and BT planning MRI were registered using DIR. Affected lymph nodes,...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 31, 2017 Category: Radiology Authors: van Heerden LE, Houweling AC, Koedooder K, van Kesteren Z, van Wieringen N, Rasch CR, Pieters BR, Bel A Tags: Radiother Oncol Source Type: research

Analysis of repeated proton beam therapy for patients with hepatocellular carcinoma.
CONCLUSION: Repeated PBT was well tolerated and safe, even though the liver doses in many patients deviated substantially from well-known critical levels for RILD. PMID: 28366501 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 30, 2017 Category: Radiology Authors: Oshiro Y, Mizumoto M, Okumura T, Fukuda K, Fukumitsu N, Abei M, Ishikawa H, Takizawa D, Sakurai H Tags: Radiother Oncol Source Type: research

Risk of heart disease in relation to radiotherapy and chemotherapy with anthracyclines among 19,464 breast cancer patients in Denmark, 1977-2005.
CONCLUSIONS: Radiotherapy for left-sided breast cancer is associated with a higher risk of heart disease than for right-sided with the largest increases seen in women who also received anthracycline-containing chemotherapy. PMID: 28365142 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 29, 2017 Category: Radiology Authors: Rehammar JC, Jensen MB, McGale P, Lorenzen EL, Taylor C, Darby SC, Videbæk L, Wang Z, Ewertz M Tags: Radiother Oncol Source Type: research

Radiobiological parameters of liver and lung metastases derived from tumor control data of 3719 metastases.
CONCLUSIONS: α/β ratios for liver and lung metastases are higher than the usually assumed 10Gy. Differences between CRC and non-CRC histology were found. Future studies confirming these findings in individual patient data are needed. PMID: 28363484 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 28, 2017 Category: Radiology Authors: Klement RJ Tags: Radiother Oncol Source Type: research

Re: Ipsilateral axillary recurrence after breast conservative surgery: The protective effect of whole breast radiotherapy.
PMID: 28363485 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 28, 2017 Category: Radiology Authors: Morgan DA Tags: Radiother Oncol Source Type: research

Magnitude and variability of respiratory-induced diaphragm motion in children during image-guided radiotherapy.
Abstract BACKGROUND AND PURPOSE: To analyse the variability of respiratory motion during image-guided radiotherapy in paediatric cancer patients and to investigate possible relationships thereof with patient-specific factors. MATERIAL AND METHODS: Respiratory-induced diaphragm motion was retrospectively analysed on 480 cone beam CTs acquired during the treatment course of 45 children (
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 28, 2017 Category: Radiology Authors: Huijskens SC, van Dijk IW, Visser J, Rasch CR, Alderliesten T, Bel A Tags: Radiother Oncol Source Type: research

Treatment options for patients with brain metastases from EGFR/ALK-driven lung cancer.
CONCLUSIONS: First-line WBRT for brain metastases from EGFR/ALK-driven NSCLC was associated with longer TTIP than SRS or TKI alone, with no difference in OS. These results could support deferral of WBRT until intracranial progression in selected patients who are closely monitored. PMID: 28363487 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 28, 2017 Category: Radiology Authors: Doherty MK, Korpanty GJ, Tomasini P, Alizadeh M, Jao K, Labbé C, Mascaux CM, Martin P, Kamel-Reid S, Tsao MS, Pintilie M, Liu G, Bradbury PA, Feld R, Leighl NB, Chung C, Shepherd FA Tags: Radiother Oncol Source Type: research

Radiation-induced rib fractures after stereotactic body radiation therapy: Predict to prevent?
PMID: 28359538 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 27, 2017 Category: Radiology Authors: Wijsman R, Braam PM, Bussink J Tags: Radiother Oncol Source Type: research

Three-dimensional-guided perineal-based interstitial brachytherapy in cervical cancer: A systematic review of technique, local control and toxicities.
CONCLUSION: Promising LC rates were found in patients with cervical cancers treated with perineal ISBT with 3D image-based planning. In this systematic review, 60% had stage IIIB disease or higher and yet a LC rate of 79% was found. LC seemed to correlate with the dose delivered to the tumour, while toxicity rates were similar to other cervical cancer series using 3D image-based brachytherapy. Perineal ISBT with 3D planning seems to be an effective and safe treatment for large advanced cervical tumours and may be a reasonable alternative to the increasingly more standard and modern intracavitary/interstitial (IC/IS) approa...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 25, 2017 Category: Radiology Authors: Mendez LC, Weiss Y, D'Souza D, Ravi A, Barbera L, Leung E Tags: Radiother Oncol Source Type: research

Dynamic conformal arc radiosurgery for arteriovenous malformations: Outcome and influence of clinical and dosimetrical data.
Abstract PURPOSE: To assess efficacy, toxicity, and their predictive factors for dynamic conformal arc arteriovenous malformations (AVM) stereotactic radiosurgery. METHOD: Data concerning 90 consecutive patients were retrospectively studied. Clinical, radiological, dosimetrical data and quality indexes were computed. RESULTS: AVM median volume was 1.06cc. Median prescribed dose was 22Gy. Total occlusion was obtained for 69% of patients. Post-radiosurgery annual hemorrhage rate was 2.2%. Predictive factor for total occlusion was delivered dose. Undesirable events occurred for 28% of patients. Predictive f...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 25, 2017 Category: Radiology Authors: Clement-Colmou K, Roualdes V, Martin SA, Josset S, Desal H, Campion L, Thillays F Tags: Radiother Oncol Source Type: research

Quality assessment of delineation and dose planning of early breast cancer patients included in the randomized Skagen Trial 1.
CONCLUSIONS: QA showed high protocol compliance and adequate dose coverage in most patients. Inter-observer variability in contouring was low. Dose parameters were in harmony with protocol regardless original or GS segmentation. PMID: 28351523 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 25, 2017 Category: Radiology Authors: Francolini G, Thomsen MS, Yates ES, Kirkove C, Jensen I, Blix ES, Kamby C, Nielsen MH, Krause M, Berg M, Mjaaland I, Schreiber A, Kasti UM, Boye K, Offersen BV Tags: Radiother Oncol Source Type: research

G9a governs colon cancer stem cell phenotype and chemoradioresistance through PP2A-RPA axis-mediated DNA damage response.
CONCLUSIONS: Our study theorized that G9a might serve as a novel target in colon cancer, which offers exciting potential in prediction of response to preoperative chemoradiotherapy in patients with advanced CRC. PMID: 28351524 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 25, 2017 Category: Radiology Authors: Luo CW, Wang JY, Hung WC, Peng G, Tsai YL, Chang TM, Chai CY, Lin CH, Pan MR Tags: Radiother Oncol Source Type: research

Patient safety in external beam radiotherapy, results of the ACCIRAD project: Current status of proactive risk assessment, reactive analysis of events, and reporting and learning systems in Europe.
CONCLUSIONS: Most European countries have taken steps to implement European directives designed to reduce the probability and magnitude of accidents in radiotherapy. Variability between countries is substantial in terms of legal frameworks, tools used to conduct proactive risk assessment and reactive analysis of events, and in the reporting and learning systems utilized. These findings underscore the need for greater harmonisation in common terminology, classification and reporting practices across Europe to improve patient safety and to enable more reliable inter-country comparisons. PMID: 28351525 [PubMed - as suppl...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 25, 2017 Category: Radiology Authors: Malicki J, Bly R, Bulot M, Godet JL, Jahnen A, Krengli M, Maingon P, Prieto Martin C, Przybylska K, Skrobała A, Valero M, Jarvinen H Tags: Radiother Oncol Source Type: research

VMAT plus a few computer-optimized non-coplanar IMRT beams (VMAT+) tested for liver SBRT.
Abstract PURPOSE: To propose a novel treatment approach, designated VMAT+, involving addition of
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 22, 2017 Category: Radiology Authors: Sharfo AW, Dirkx ML, Breedveld S, Romero AM, Heijmen BJ Tags: Radiother Oncol Source Type: research

The effect of post-mastectomy radiation in women with one to three positive nodes enrolled on the control arm of BCIRG-005 at ten year follow-up.
CONCLUSIONS: In this cohort of patients with N1 disease treated with modern systemic therapy, PMRT improves LRC but has no effect on OS. The rates of OS were excellent, irrespective of adjuvant radiation. PMID: 28341062 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 22, 2017 Category: Radiology Authors: Tam MM, Wu SP, Perez C, Gerber NK Tags: Radiother Oncol Source Type: research

Recurrence patterns after a decreased dose of 40Gy to the elective treated neck in head and neck cancer.
CONCLUSIONS: The actuarial rate of recurrence in the electively irradiated lymph node regions was 3.9% (95% CI 1.8-6.0) at 2years. This incidence is comparable to recurrence rates after standard dose of 50Gy, suggesting that lower doses to the elective neck do not result in higher regional recurrences. PMID: 28342647 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 22, 2017 Category: Radiology Authors: Nevens D, Duprez F, Daisne JF, Schatteman J, Van der Vorst A, De Neve W, Nuyts S Tags: Radiother Oncol Source Type: research

The first clinical implementation of a real-time six degree of freedom target tracking system during radiation therapy based on Kilovoltage Intrafraction Monitoring (KIM).
CONCLUSION: This treatment represents, to the best of our knowledge, the first time a cancer patient's tumour position and rotation have been monitored in real-time during treatment. The 6 DoF KIM system has sub-millimetre accuracy and precision in all three translational axes, and less than 1° accuracy and 4° precision in all three rotational axes. PMID: 28342648 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 22, 2017 Category: Radiology Authors: Nguyen DT, O'Brien R, Kim JH, Huang CY, Wilton L, Greer P, Legge K, Booth JT, Poulsen PR, Martin J, Keall PJ Tags: Radiother Oncol Source Type: research

A population based statistical model for daily geometric variations in the thorax.
CONCLUSIONS: A PCA based model for systematic geometric variations in the thorax was developed, and its accuracy determined. Such a model can serve as a basis for probability based treatment planning in lung cancer patients. PMID: 28320555 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 17, 2017 Category: Radiology Authors: Szeto YZ, Witte MG, van Herk M, Sonke JJ Tags: Radiother Oncol Source Type: research

Constraints for symptomatic radiation pneumonitis of helical tomotherapy hypofractionated simultaneous multitarget radiotherapy for pulmonary metastasis from hepatocellular carcinoma.
This study was aimed to identify the clinical and dosimetric parameters that predict symptomatic radiation pneumonitis (SRP, radiation pneumonitis≥2 grade) in patients with pulmonary metastasis from hepatocellular carcinoma (HCC) after helical tomotherapy (HT) hypofractionated simultaneous multitarget radiotherapy. MATERIALS AND METHODS: 62 patients with 407 pulmonary metastases from HCC were consecutively treated with HT. The median radiation dose was a 49.7Gy in 4.0Gy/fraction to 95% of the planning target volume (PTV). The associations between the clinical and dosimetric data and incidences of SRP were analyzed....
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 14, 2017 Category: Radiology Authors: Lin G, Xiao H, Zeng Z, Xu Z, He J, Sun T, Liu J, Guo G, Ji W, Hu Y Tags: Radiother Oncol Source Type: research

Novel recursive partitioning analysis classification for newly diagnosed glioblastoma: A multi-institutional study highlighting the MGMT promoter methylation and IDH1 gene mutation status.
Abstract BACKGROUND AND PURPOSE: To refine the recursive partitioning analysis (RPA) classification for glioblastoma incorporating the MGMT methylation and IDH1 mutation status. METHODS AND MATERIALS: Three-hundred forty patients were treated with radiotherapy plus concurrent and adjuvant temozolomide in three tertiary-referral hospitals. MGMT methylation and IDH1 mutation status were available in all patients. Methylation of the MGMT (MGMTmeth) and mutation of IDH1 (IDH1mut) were observed in 42.4% and 6.2% of the patients, respectively. RESULTS: The median follow-up for survivors and all patients was 33...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 13, 2017 Category: Radiology Authors: Wee CW, Kim E, Kim N, Kim IA, Kim TM, Kim YJ, Park CK, Kim JW, Kim CY, Choi SH, Kim JH, Park SH, Choe G, Lee ST, Chang JH, Kim SH, Suh CO, Kim IH Tags: Radiother Oncol Source Type: research

Acute toxicity and surgical complications after preoperative (chemo)radiation therapy for rectal cancer in patients with inflammatory bowel disease.
CONCLUSION: Results did not show excessive rates of toxicity or post-operative complications and support the use of standard preoperative therapies for rectal cancer (especially SC-RT) in IBD patients with relatively indolent disease. Caution is warranted in patients with active IBD, since the exact impact of active bowel inflammation could not be determined retrospectively. Prospective studies should investigate the influence of active IBD on acute and late toxicity in patients receiving pelvic irradiation. PMID: 28291546 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 10, 2017 Category: Radiology Authors: Bosch SL, van Rooijen SJ, Bökkerink GM, Braam HJ, Derikx LA, Poortmans P, Marijnen CA, Nagtegaal ID, de Wilt JH Tags: Radiother Oncol Source Type: research

Clinical assessment of coiled fiducial markers as internal surrogates for hepatocellular carcinomas during gated stereotactic body radiotherapy with a real-time tumor-tracking system.
CONCLUSIONS: Using an RTRT system and Visicoil markers, gated SBRT was well tolerated in patients with HCC. This can be considered a safe treatment strategy with potential for delivering favorable outcomes. PMID: 28285839 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 9, 2017 Category: Radiology Authors: Hanazawa H, Takahashi S, Shiinoki T, Park SC, Yuasa Y, Koike M, Kawamura S, Shibuya K Tags: Radiother Oncol Source Type: research

Secondary malignancies after rectal cancer resection with and without radiation therapy: A propensity-adjusted, population-based SEER analysis.
PM Abstract BACKGROUND: The relationship between radiation therapy for rectal cancer and secondary malignancies is debated. The present study is the first population-based analysis using conventional multivariable analyses as well as propensity score matching to assess this relationship. METHODS: Overall, 77,484 patients after resection of localized or locally advanced rectal adenocarcinoma diagnosed between 1973 and 2012 were identified in the Surveillance, Epidemiology, and End Results (SEER) registry. The occurrence of secondary malignancies diagnosed at least 1 (median follow up 5.8years [1-39.9years]) y...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 9, 2017 Category: Radiology Authors: Warschkow R, Güller U, Cerny T, Schmied BM, Plasswilm L, Putora PM Tags: Radiother Oncol Source Type: research

Dosimetric impact of contouring and needle reconstruction uncertainties in US-, CT- and MRI-based high-dose-rate prostate brachytherapy treatment planning.
CONCLUSIONS: Uncertainties related to contouring and reconstruction in US- and CT-based HDR-BT treatment plans resulted in a systematic overestimation of the prescribed target dose. Inter-modality uncertainties (US and CT versus MR) were larger than MR intra-observer uncertainties. PMID: 28284493 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 8, 2017 Category: Radiology Authors: Rylander S, Buus S, Pedersen EM, Bentzen L, Tanderup K Tags: Radiother Oncol Source Type: research

Positron emission tomography and computed tomographic imaging (PET/CT) for dose planning purposes of thoracic radiation with curative intent in lung cancer patients: A systematic review and meta-analysis.
CONCLUSION: PET/CT for dose planning improves target definition and patient selection. Approximately two in five patients had a significant change in target definition and one in five received palliative treatment instead. The proportions seem to be similar regardless of the availability of a previous staging-PET. PMID: 28284494 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 8, 2017 Category: Radiology Authors: Hallqvist A, Alverbratt C, Strandell A, Samuelsson O, Björkander E, Liljegren A, Albertsson P Tags: Radiother Oncol Source Type: research

Planning study for Merkel cell carcinoma based on the relapse pattern.
CONCLUSION: The planning study confirms feasibility of highly conformal irradiation of IT pathways based on individualized target delineation. Currently, patients referred for non-metastatic MCC are encouraged to enroll in a prospective clinical study that evaluates the feasibility of radiation of IT pathways. PMID: 28284495 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 8, 2017 Category: Radiology Authors: Hoeller U, Schubert T, Mueller T, Budach V, Ghadjar P, Brenner W, Kuschke W Tags: Radiother Oncol Source Type: research

Supine craniospinal irradiation in pediatric patients by proton pencil beam scanning.
Abstract BACKGROUND AND PURPOSE: Proton therapy is the emerging treatment modality for craniospinal irradiation (CSI) in pediatric patients. Herein, special methods adopted for CSI at proton Therapy Center of Trento by pencil beam scanning (PBS) are comprehensively described. MATERIALS AND METHODS: Twelve pediatric patients were treated by proton PBS using two/three isocenters. Special methods refer to: (i) patient positioning in supine position on immobilization devices crossed by the beams; (ii) planning field-junctions via the ancillary-beam technique; (iii) achieving lens-sparing by three-beams whole-brai...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 7, 2017 Category: Radiology Authors: Farace P, Bizzocchi N, Righetto R, Fellin F, Fracchiolla F, Lorentini S, Widesott L, Algranati C, Rombi B, Vennarini S, Amichetti M, Schwarz M Tags: Radiother Oncol Source Type: research

Stereotactic body radiotherapy for oligo-metastatic liver disease - Influence of pre-treatment chemotherapy and histology on local tumor control.
CONCLUSIONS: Besides dose, histology and pretreatment chemotherapy were important factors influencing local TCP in this large cohort of liver metastases. After adjusting for prior chemotherapy, our data add to the emerging evidence that breast cancer metastases do respond better to hypofractionated SBRT compared to other histologies. PMID: 28274491 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 5, 2017 Category: Radiology Authors: Klement RJ, Guckenberger M, Alheid H, Allgäuer M, Becker G, Blanck O, Boda-Heggemann J, Brunner T, Duma M, Gerum S, Habermehl D, Hildebrandt G, Lewitzki V, Ostheimer C, Papachristofilou A, Petersen C, Schneider T, Semrau R, Wachter S, Andratschke N Tags: Radiother Oncol Source Type: research

Extent and computed tomography appearance of early radiation induced lung injury for non-small cell lung cancer.
CONCLUSION: Radiologic injuries were frequently found in follow-up CT scans after radiotherapy for NSCLC patients. The risk of a radiologic response increased with increasing time and lung dose metrics, and depended on patient age and smoking status. PMID: 28259449 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 1, 2017 Category: Radiology Authors: Bernchou U, Christiansen RL, Asmussen JT, Schytte T, Hansen O, Brink C Tags: Radiother Oncol Source Type: research

Modality-specific target definition for laryngeal and hypopharyngeal cancer on FDG-PET, CT and MRI.
CONCLUSION: For laryngohypopharyngeal tumors, 45-52% target volume reduction compared with CTV10mm is achievable when modality-specific CTV margins are used. PET-based CTVs were significantly smaller compared to CT- and MRI-based CTVs. PMID: 28259450 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 1, 2017 Category: Radiology Authors: Ligtenberg H, Jager EA, Caldas-Magalhaes J, Schakel T, Pameijer FA, Kasperts N, Willems SM, Terhaard CH, Raaijmakers CP, Philippens ME Tags: Radiother Oncol Source Type: research

Reply to the Letter to the Editor by H. Yamazaki et al.
r R PMID: 28259451 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 1, 2017 Category: Radiology Authors: Tanderup K, Sturdza A, Fokdal L, Kirisits C, Lindegaard JC, Pötter R Tags: Radiother Oncol Source Type: research

Target position uncertainty during visually guided deep-inspiration breath-hold radiotherapy in locally advanced lung cancer.
CONCLUSION: Intra- and inter-breath-hold uncertainty of tumours and lymph nodes were small in visually guided breath-hold radiotherapy of NSCLC. Target motion could be substantially reduced, but not eliminated, using visually guided DIBH. PMID: 28245908 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 25, 2017 Category: Radiology Authors: Scherman Rydhög J, Riisgaard de Blanck S, Josipovic M, Irming Jølck R, Larsen KR, Clementsen P, Lars Andersen T, Poulsen PR, Fredberg Persson G, Munck Af Rosenschold P Tags: Radiother Oncol Source Type: research

The feasibility of semi-automatically generated red bone marrow segmentations based on MR-only for patients with gynecologic cancer.
CONCLUSION: This study shows that delineations of the RBM for the radiotherapy with RBM sparing can be generated semi-automatically using MR scans only. PMID: 28238449 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 23, 2017 Category: Radiology Authors: Andreychenko A, Kroon PS, Maspero M, Jürgenliemk-Schulz I, De Leeuw AA, Lam MG, Lagendijk JJ, van den Berg CA Tags: Radiother Oncol Source Type: research

Individualized early death and long-term survival prediction after stereotactic radiosurgery for brain metastases of non-small cell lung cancer: Two externally validated nomograms.
In this study, two nomograms were developed to overcome these limitations. METHODS: 495 patients with BMs of NSCLC treated with SRS for a limited number of BMs in four Dutch radiation oncology centers were identified and divided in a training cohort (n=214, patients treated in one hospital) and an external validation cohort n=281, patients treated in three other hospitals). Using the training cohort, nomograms were developed for prediction of early death (12months) with prognostic factors for survival. Accuracy of prediction was defined as the area under the curve (AUC) by receiver operating characteristics analysis f...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 23, 2017 Category: Radiology Authors: Zindler JD, Jochems A, Lagerwaard FJ, Beumer R, Troost EG, Eekers DB, Compter I, van der Toorn PP, Essers M, Oei B, Hurkmans CW, Bruynzeel AM, Bosmans G, Swinnen A, Leijenaar RT, Lambin P Tags: Radiother Oncol Source Type: research

Comment on "Effect of tumor dose, volume and overall treatment time on local control after radiochemotherapy including MRI guided brachytherapy of locally advanced cervical cancer" Kari Tanderup et al.
Comment on "Effect of tumor dose, volume and overall treatment time on local control after radiochemotherapy including MRI guided brachytherapy of locally advanced cervical cancer" Kari Tanderup et al. Radiother Oncol. 2017 Feb 22;: Authors: Yamazaki H, Nakamura S, Suzuki G, Yoshida K, Kotsuma T PMID: 28237399 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 22, 2017 Category: Radiology Authors: Yamazaki H, Nakamura S, Suzuki G, Yoshida K, Kotsuma T Tags: Radiother Oncol Source Type: research

Unraveling biophysical interactions of radiation pneumonitis in non-small-cell lung cancer via Bayesian network analysis.
CONCLUSIONS: Our developed BN approach successfully handled a high number of heterogeneous variables in a small dataset, demonstrating potential for unraveling relevant biophysical features that could enhance prediction of RP2, although the current observations would require further independent validation. PMID: 28237401 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 22, 2017 Category: Radiology Authors: Luo Y, El Naqa I, McShan DL, Ray D, Lohse I, Matuszak MM, Owen D, Jolly S, Lawrence TS, Kong FS, Ten Haken RK Tags: Radiother Oncol Source Type: research

Understanding variations in the use of hypofractionated radiotherapy and its specific indications for breast cancer: A mixed-methods study.
This study assessed the patterns of HWBRT adoption in Catalonia (Spain). MATERIAL AND METHODS: We used a mixed-methods approach based on an explanatory sequential design, first collecting and analysing quantitative data on HWBRT use (>2.5Gy per fraction) in 11 public radiotherapy centres (2005-2015) and then performing 25 semi-structured interviews with all department heads and reference radiation oncologist/s. RESULTS: Of the 34,859 patients fulfiling the study criteria over the study period, just 12% were hypofractionated, reaching a percentage of 29% in 2015 (p
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 21, 2017 Category: Radiology Authors: Prades J, Algara M, Espinàs JA, Farrús B, Arenas M, Reyes V, García-Reglero V, Cambra MJ, Rubio E, Anglada L, Eraso A, Pedro A, Fuentes-Raspall MJ, Tuset V, Solà J, Borras JM Tags: Radiother Oncol Source Type: research

Individual case review in a phase 3 randomized trial to investigate the role of internal mammary lymph node irradiation for breast cancer: Korean Radiation Oncology Group 08-06 study.
CONCLUSION: This ICR demonstrated overall protocol compliance, despite significant differences with regard to IMN irradiation and organs at risk according to subgroups and adopted field arrangements. PMID: 28236539 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 21, 2017 Category: Radiology Authors: Yoon HI, Yoon J, Chung Y, Nam CM, Cha H, Choi J, Lee J, Han HJ, Cho Y, Kim YB, Suh CO Tags: Radiother Oncol Source Type: research

A cardiac contouring atlas for radiotherapy.
This study presents a reproducible method for contouring left ventricular and coronary arterial segments on radiotherapy CT-planning scans. MATERIAL AND METHODS: Segments were defined from cardiology models and agreed by two cardiologists. Reference atlas contours were delineated and written guidelines prepared. Six radiation oncologists tested the atlas. Spatial variation was assessed using the DICE similarity coefficient (DSC) and the directed Hausdorff average distance (d→H,avg). The effect of spatial variation on doses was assessed using six different breast cancer regimens. RESULTS: The atlas enabled co...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 20, 2017 Category: Radiology Authors: Duane F, Aznar MC, Bartlett F, Cutter DJ, Darby SC, Jagsi R, Lorenzen EL, McArdle O, McGale P, Myerson S, Rahimi K, Vivekanandan S, Warren S, Taylor CW Tags: Radiother Oncol Source Type: research

FDG uptake in normal tissues assessed by PET during treatment has prognostic value for treatment results in head and neck squamous cell carcinomas undergoing radiochemotherapy.
CONCLUSIONS: FDG uptake in normal tissues within the irradiated volume measured by PET during treatment has significant prognostic value in HNSCC. This effect may potentially be of use for personalized treatment adaptation. PMID: 28222892 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 17, 2017 Category: Radiology Authors: Zschaeck S, Löck S, Leger S, Haase R, Bandurska-Luque A, Appold S, Kotzerke J, Zips D, Richter C, Gudziol V, Schreiber A, Zöphel K, Baumann M, Krause M Tags: Radiother Oncol Source Type: research

Phase I trial of radiation therapy and sorafenib in unresectable liver metastases.
CONCLUSIONS: Sorafenib and 21.6Gy in 6 fraction WLRT resulted in unacceptably high rates of liver toxicity. Although sorafenib combined with SBRT was tolerable, the observed efficacy does not merit further clinical evaluation. PMID: 28202227 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 12, 2017 Category: Radiology Authors: Goody RB, Brade AM, Wang L, Craig T, Brierley J, Dinniwell R, Wong RK, Cho C, Kim J, Kassam Z, Ringash J, Knox JJ, Dawson LA Tags: Radiother Oncol Source Type: research

Cross-institutional knowledge-based planning (KBP) implementation and its performance comparison to Auto-Planning Engine (APE).
CONCLUSION: APE and OVH-KBP's plan quality is comparable. Institutional-protocol differences can be addressed to allow cross-institutional library sharing. PMID: 28202228 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 12, 2017 Category: Radiology Authors: Wu B, Kusters M, Kunze-Busch M, Dijkema T, McNutt T, Sanguineti G, Bzdusek K, Dritschilo A, Pang D Tags: Radiother Oncol Source Type: research

So long, Farewell, Au revoir, Auf Weidersehen. In regard to Overgaard (Radiother Oncol. 2016 Dec; 121(3):345-347).
PMID: 28196642 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 10, 2017 Category: Radiology Authors: Salem A Tags: Radiother Oncol Source Type: research

Radiotherapy after Sentinel Lymph Node Biopsy (SLNB) using SIENNA+ ®, super paramagnetic iron oxide particles (SPIO): Prospective study of tolerance and toxicity.
Radiotherapy after Sentinel Lymph Node Biopsy (SLNB) using SIENNA+®, super paramagnetic iron oxide particles (SPIO): Prospective study of tolerance and toxicity. Radiother Oncol. 2017 Feb 10;: Authors: Kirova YM, Chilles A, Ly N, Tardivon A, Alran S PMID: 28196643 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 10, 2017 Category: Radiology Authors: Kirova YM, Chilles A, Ly N, Tardivon A, Alran S Tags: Radiother Oncol Source Type: research

Clinical implementation of coverage probability planning for nodal boosting in locally advanced cervical cancer.
rd JC Abstract PURPOSE: To implement coverage probability (CovP) for dose planning of simultaneous integrated boost (SIB) of pathologic lymph nodes in locally advanced cervical cancer (LACC). MATERIAL AND METHODS: CovP constraints for SIB of the pathological nodal target (PTV-N) with a central dose peak and a relaxed coverage at the perimeter were generated for use with the treatment planning system Eclipse: PTV-N D98>90%, CTV-N D98>100% and CTV-N D50>101.5% of prescribed dose. Dose of EBRT was 45Gy/25 fx with a SIB of 55-57.5Gy depending on expected dose from brachytherapy (BT). Twenty-five previous...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 9, 2017 Category: Radiology Authors: Ramlov A, Assenholt MS, Jensen MF, Grønborg C, Nout R, Alber M, Fokdal L, Tanderup K, Lindegaard JC Tags: Radiother Oncol Source Type: research

Pattern of solid and hematopoietic second malignancy after local therapy for prostate cancer.
CONCLUSIONS: EBRT and BT resulted in statistically equivalent increase in both solid and hematopoietic SM compared to RP. EBRT in more recent years resulted in significantly decreased solid and hematopoietic SM, coinciding with increased utilization of IMRT. PMID: 28187996 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 7, 2017 Category: Radiology Authors: Wang C, King CR, Kamrava M, Iwamoto KS, Chen AM, Low D, Kupelian PA, Steinberg ML Tags: Radiother Oncol Source Type: research

Treatment plan optimization and robustness of (106)Ru eye plaque brachytherapy using a novel software tool.
CONCLUSION: Critical structures in the treatment of uveal melanomas with (106)Ru plaques can benefit from the proposed, computational treatment plan optimization. PMID: 28185660 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 6, 2017 Category: Radiology Authors: Heilemann G, Fetty L, Dulovits M, Blaickner M, Nesvacil N, Georg D, Dunavoelgyi R Tags: Radiother Oncol Source Type: research

The value of adaptive preoperative radiotherapy in management of soft tissue sarcoma.
CONCLUSION: GTV expansion of>1cm during RT may result in target underdosage independent of RT technique. ART applied offline for TV increases>1cm is a practical adaptive strategy to ensure tumour coverage during RT. TV shrinkage may allow for normal tissue sparing, which should be investigated prospectively. PMID: 28169043 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 3, 2017 Category: Radiology Authors: Dickie C, Parent A, Griffin AM, Wunder J, Ferguson P, Chung PW, Craig T, Sharpe M, Becker N, Shultz D, Catton CN, O'Sullivan B Tags: Radiother Oncol Source Type: research

Long-term outcome of phase I/II prospective study of dose-escalated proton therapy for early-stage non-small cell lung cancer.
CONCLUSIONS: According to our long-term follow-up data, proton therapy with ablative doses is well tolerated and effective in medically inoperable early-stage NSCLC. Systemic therapy should be considered to reduce the rate of distant metastasis in cases of T2 and T3 lesions. PMID: 28139305 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 27, 2017 Category: Radiology Authors: Chang JY, Zhang W, Komaki R, Choi NC, Chan S, Gomez D, O'Reilly M, Jeter M, Gillin M, Zhu X, Zhang X, Mohan R, Swisher S, Hahn S, Cox JD Tags: Radiother Oncol Source Type: research