Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology RSS feedThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Independent validation of a new reirradiation risk score (RRRS) for glioma patients predicting post-recurrence survival: A multicenter DKTK/ROG analysis.
CONCLUSIONS: The RRRS has been successfully validated in an independent patient cohort. This linear combination of three easily determined clinicopathological factors allows for a reliable classification of patients and may be used as stratification factor for future trials. PMID: 29433917 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 9, 2018 Category: Radiology Authors: Niyazi M, Adeberg S, Kaul D, Boulesteix AL, Bougatf N, Fleischmann DF, Grün A, Krämer A, Rödel C, Eckert F, Paulsen F, Kessel KA, Combs SE, Oehlke O, Grosu AL, Seidlitz A, Lattermann A, Krause M, Baumann M, Guberina M, Stuschke M, Budach V, Belka C, De Tags: Radiother Oncol Source Type: research

The first clinical implementation of real-time image-guided adaptive radiotherapy using a standard linear accelerator.
CONCLUSION: The clinical implementation of real-time image-guided adaptive radiotherapy on a standard linear accelerator using KIM and MLC tracking is feasible. This achievement paves the way for real-time IGART to be a mainstream treatment option. PMID: 29428258 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 7, 2018 Category: Radiology Authors: Keall PJ, Nguyen DT, O'Brien R, Caillet V, Hewson E, Poulsen PR, Bromley R, Bell L, Eade T, Kneebone A, Martin J, Booth JT Tags: Radiother Oncol Source Type: research

The influence of tissue composition uncertainty on dose distributions in brachytherapy.
CONCLUSIONS: Updated elemental compositions are needed to optimize MBDCA-based dosimetry. Until then, tissue compositions based on gross simplifications in early studies will dominate the uncertainties in tissue heterogeneity. PMID: 29428259 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 7, 2018 Category: Radiology Authors: Mann-Krzisnik D, Verhaegen F, Enger SA Tags: Radiother Oncol Source Type: research

Comparison of dosimetric parameters derived from whole organ and wall contours for bladder and rectum in cervical cancer patients treated with intracavitary and interstitial brachytherapy.
Abstract For volumes up to 2 cm3 of the bladder and possibly up to 5 cm3 of the rectum, doses computed from the whole organ were good estimates of the doses in the wall in cervix brachytherapy, and there were no significant differences between patients treated with or without interstitial needles. PMID: 29426638 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 6, 2018 Category: Radiology Authors: Gerber R, Rink A, Croke J, Borg J, Beiki-Ardakani A, Fyles A, Milosevic M, Xie J, Keller H, Han K Tags: Radiother Oncol Source Type: research

Clinical implementation of contrast-enhanced four-dimensional dual-energy computed tomography for target delineation of pancreatic cancer.
This study demonstrates the application of contrast-enhanced four-dimensional dual-energy computed tomography (CE-4D-DECT) for tumor delineation and assesses the objective and subjective image quality. MATERIAL AND METHODS: Twelve patients underwent CE-4D-DECT, and quantitative spectral analysis was performed on the resulting virtual monochromatic images (VMI) to determine the optimal VMI (O-VMI) with the highest contrast-to-noise ratio (CNR). The objective value of the CNR between pancreatic parenchyma and tumor, and the subjective measurement with five-point scale were compared between O-VMI, standard VMI (S-VMI, 77...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 5, 2018 Category: Radiology Authors: Ohira S, Wada K, Hirata T, Kanayama N, Ikawa T, Karino T, Nitta Y, Isono M, Ueda Y, Miyazaki M, Koizumi M, Teshima T Tags: Radiother Oncol Source Type: research

A qualitative signature for predicting pathological response to neoadjuvant chemoradiation in locally advanced rectal cancers.
CONCLUSIONS: The signature consisting of 27 gene pairs can robustly predict clinical response of LARCs to nCRT. PMID: 29402470 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 2, 2018 Category: Radiology Authors: Guo Y, Jiang W, Ao L, Song K, Chen H, Guan Q, Gao Q, Cheng J, Liu H, Wang X, Guan G, Guo Z Tags: Radiother Oncol Source Type: research

Prognostic significance of pretreatment total lymphocyte count and neutrophil-to-lymphocyte ratio in extensive-stage small-cell lung cancer.
Abstract BACKGROUND: We evaluated pretreatment total lymphocyte count (TLC, marker of immunosuppression), neutrophil-to-lymphocyte ratio (NLR, marker of inflammation), and overall survival (OS) in patients with extensive-stage small-cell lung cancer (ES-SCLC). METHODS: Pretreatment blood characteristics, age, sex, performance status, race, stage (M1a vs. M1b), number and location of metastases, weight loss, smoking status, chemotherapy cycles (
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 2, 2018 Category: Radiology Authors: Suzuki R, Lin SH, Wei X, Allen PK, Welsh JW, Byers LA, Komaki R Tags: Radiother Oncol Source Type: research

Radiotherapy for prostate cancer - Does daily image guidance with tighter margins improve patient reported outcomes compared to weekly orthogonal verified irradiation? Results from a randomized controlled trial.
, Kaasa S, Solberg A Abstract BACKGROUND: Novel cancer drugs are subject to strict scientific evaluation of safety and efficacy and usually undergo a cost effectiveness analysis before approval for use in clinical practice. For new techniques in radiotherapy (RT) such as image-guided radiotherapy (IGRT), this is often not the case. We performed a randomized controlled trial to compare daily cone beam computer tomography (CBCT) IGRT with reduced planning target volume (PTV) margins vs weekly orthogonal portal imaging with conventional PTV margins. The primary aim of the study was to investigate the effect of two di...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 2, 2018 Category: Radiology Authors: Tøndel H, Lund JÅ, Lydersen S, Wanderås AD, Aksnessæther B, Jensen CA, Kaasa S, Solberg A Tags: Radiother Oncol Source Type: research

Impact of pemetrexed on intracranial disease control and radiation necrosis in patients with brain metastases from non-small cell lung cancer receiving stereotactic radiation.
CONCLUSIONS: Patients receiving pemetrexed after brain-directed stereotactic radiation appear to benefit from improved intracranial disease control at the possible expense of radiation-related radiographic necrosis. Whether symptomatic radiation injury occurs more frequently in patients receiving pemetrexed requires further study. PMID: 29398153 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 2, 2018 Category: Radiology Authors: Cagney DN, Martin AM, Catalano PJ, Reitman ZJ, Mezochow GA, Lee EQ, Wen PY, Weiss SE, Brown PD, Ahluwalia MS, Arvold ND, Tanguturi SK, Haas-Kogan DA, Alexander BM, Redig AJ, Aizer AA Tags: Radiother Oncol Source Type: research

Evaluation of clinical and endoscopic toxicity after external beam radiotherapy and endorectal brachytherapy in elderly patients with rectal cancer treated in the HERBERT study.
CONCLUSION: For elderly patients with rectal cancer, definitive radiotherapy can provide good tumour response but has a substantial risk of toxicity. The potential benefit and risks of a HDREBT boost above EBRT alone must be further evaluated. PMID: 29398154 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 2, 2018 Category: Radiology Authors: Rijkmans EC, van Triest B, Nout RA, Kerkhof EM, Buijsen J, Rozema T, Franssen JH, Velema LA, Laman MS, Cats A, Marijnen CAM Tags: Radiother Oncol Source Type: research

Differentiation between radiation-induced brain injury and glioma recurrence using 3D pCASL and dynamic susceptibility contrast-enhanced perfusion-weighted imaging.
This study was performed to validate the efficacy of three-dimensional pseudocontinuous arterial spin labeling (pCASL) compared with dynamic susceptibility contrast-enhanced perfusion-weighted imaging (DSC-PWI) in distinguishing radiation-induced brain injury from glioma recurrence in patients with glioma. METHODS: Both 3D pCASL and DSC-PWI were performed using a 3.0 Tesla scanner in 69 patients with previously resected and irradiated glioma who displayed newly developed abnormal contrast-enhanced lesions. The included patients were classified into a radiation-induced brain injury group (n = 34) and a glioma rec...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 1, 2018 Category: Radiology Authors: Wang YL, Chen S, Xiao HF, Li Y, Wang Y, Liu G, Lou X, Ma L Tags: Radiother Oncol Source Type: research

Update of the systematic review of palliative radiation therapy fractionation for bone metastases.
Abstract PURPOSE: Radiation therapy is an effective modality for pain management of symptomatic bone metastases. We update the previous meta-analyses of randomized trials comparing single fraction to multiple fractions of radiation therapy in patients with uncomplicated bone metastases. METHODS: A literature search was conducted in Ovid Medline, Embase, and Cochrane Central Register. Ten new randomized trials were identified since 2010, five with adequate and appropriate data for inclusion, resulting in a total of 29 trials that were analyzed. Forest plots based on each study's odds ratios were computed using...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 31, 2018 Category: Radiology Authors: Rich SE, Chow R, Raman S, Liang Zeng K, Lutz S, Lam H, Silva MF, Chow E Tags: Radiother Oncol Source Type: research

Development and validation of an MRI-based model to predict response to chemoradiotherapy for rectal cancer.
CONCLUSION: An MRI-based prediction model of (near-)complete pathological response following CRT in rectal cancer patients, shows a high predictive performance in an external validation cohort. The clinically relevant features in the model make it an interesting tool for implementation of organ-preserving strategies in rectal cancer. PMID: 29395287 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 30, 2018 Category: Radiology Authors: Bulens P, Couwenberg A, Haustermans K, Debucquoy A, Vandecaveye V, Philippens M, Zhou M, Gevaert O, Intven M Tags: Radiother Oncol Source Type: research

Review of the patient positioning reproducibility in head-and-neck radiotherapy using Statistical Process Control.
CONCLUSION: SPC is able to track changes in the reproducibility of patient positioning in head-and-neck radiation oncology, and distinguish between systematic and random process changes. Identification of process changes underlying these trends requires additional statistical analysis and seems only possible when the changes do not overlap in time. PMID: 29395288 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 27, 2018 Category: Radiology Authors: Moore SJ, Herst PM, Louwe RJW Tags: Radiother Oncol Source Type: research

Palliative radiotherapy for locally advanced non-metastatic head and neck cancer: A survey of UK national practice.
PMID: 29366519 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 20, 2018 Category: Radiology Authors: Iqbal MS, Kelly C, Kovarik J, Goranov B, Shaikh G, Morgan D, Dobrowsky W, Paleri V Tags: Radiother Oncol Source Type: research

Clinical significance of soluble programmed cell death ligand-1 (sPD-L1) in hepatocellular carcinoma patients treated with radiotherapy.
CONCLUSIONS: The level of sPD-L1 was associated with tumor aggressiveness and outcomes, suggesting its role as a possible predictive biomarker. The increases in sPD-L1 after RT suggests that combined treatment with RT and immune checkpoint inhibitors may be a promising therapeutic strategy in HCC. PMID: 29366520 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 20, 2018 Category: Radiology Authors: Kim HJ, Park S, Kim KJ, Seong J Tags: Radiother Oncol Source Type: research

A prospective study of the safety and efficacy of liver stereotactic body radiotherapy in patients with and without prior liver-directed therapy.
CONCLUSIONS: Liver SBRT is a safe and effective treatment even in the setting of prior liver-directed surgical and ablative therapies. PMID: 29366521 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 20, 2018 Category: Radiology Authors: Moon DH, Wang AZ, Tepper JE Tags: Radiother Oncol Source Type: research

Photon vs. proton radiochemotherapy: Effects on brain tissue volume and perfusion.
Abstract BACKGROUND AND PURPOSE: To compare the structural and hemodynamic changes of healthy brain tissue in the cerebral hemisphere contralateral to the tumor following photon and proton radiochemotherapy. MATERIALS AND METHODS: Sixty-seven patients (54.9 ±14.0 years) diagnosed with glioblastoma undergoing adjuvant photon (n = 47) or proton (n = 19) radiochemotherapy with temozolomide after tumor resection underwent T1-weighted and arterial spin labeling MRI. Changes in volume and perfusion before and 3 to 6 months after were compared between therapies. RESULTS: A decrease in gray ...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 19, 2018 Category: Radiology Authors: Petr J, Platzek I, Hofheinz F, Mutsaerts HJMM, Asllani I, van Osch MJP, Seidlitz A, Krukowski P, Gommlich A, Beuthien-Baumann B, Jentsch C, Maus J, Troost EGC, Baumann M, Krause M, van den Hoff J Tags: Radiother Oncol Source Type: research

Skin CanceR Brachytherapy vs External beam radiation therapy (SCRiBE) meta-analysis.
Abstract BACKGROUND AND PURPOSE: To compare cosmesis and local recurrence (LR) of definitive external beam radiation therapy (EBRT) vs brachytherapy (BT) for indolent basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) of the skin. MATERIALS AND METHODS: Studies including patients with T1-2 N0 SCCs/BCCs treated with definitive EBRT/BT and ≥10 months follow-up were analyzed. The primary endpoint was post-treatment cosmesis, categorized as "good," "fair," or "poor." The secondary endpoint was LR. Mixed effects regression models were used to estimate weighted linear ...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 19, 2018 Category: Radiology Authors: Zaorsky NG, Lee CT, Zhang E, Galloway TJ Tags: Radiother Oncol Source Type: research

Palliative radiotherapy for locally advanced non-metastatic head and neck cancer: A systematic review.
CONCLUSIONS: The choice of palliative radiotherapy varies significantly. This is in contrast to regimens of curative radiotherapy for locally advanced head and neck cancer, which are well standardised. Given the reported relatively short overall survival of this patient group, an ideal treatment should be of the shortest possible duration whilst ensuring effective palliation and minimal side effects. Future well designed trials are needed to evaluate quality of life and duration of side effects in addition to survival and severity of toxicities in this group of patients. PMID: 29370986 [PubMed - as supplied by publish...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 19, 2018 Category: Radiology Authors: Shahid Iqbal M, Kelly C, Kovarik J, Goranov B, Shaikh G, Morgan D, Dobrowsky W, Paleri V Tags: Radiother Oncol Source Type: research

Optimization of combined proton-photon treatments.
CONCLUSIONS: A limited number of proton fractions can best be used if protons hypofractionate parts of the GTV while maintaining near-uniform fractionation in dose-limiting normal tissues. PMID: 29370987 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 19, 2018 Category: Radiology Authors: Unkelbach J, Bangert M, De Amorim Bernstein K, Andratschke N, Guckenberger M Tags: Radiother Oncol Source Type: research

A simple clinical method for predicting the benefit of prone vs. supine positioning in reducing heart exposure during left breast radiotherapy.
CONCLUSION: We consider this simple clinical tool appropriate for assisting individual positioning aiming at maximum heart protection during left breast irradiation. PMID: 29373194 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 17, 2018 Category: Radiology Authors: Kahán Z, Rárosi F, Gaál S, Cserháti A, Boda K, Darázs B, Kószó R, Lakosi F, Gulybán Á, Coucke PA, Varga Z Tags: Radiother Oncol Source Type: research

Ototoxicity and cochlear sparing in children with medulloblastoma: Proton vs. photon radiotherapy.
Abstract PURPOSE: To compare ototoxicity rates between medulloblastoma patients treated with protons vs. photons. MATERIALS AND METHODS: The study included 84 children diagnosed with medulloblastoma treated with either passively scattered protons (n = 38) or photons (n = 46). Patients underwent maximal safe resection followed by craniospinal irradiation, posterior fossa and/or tumor bed boost and chemotherapy according to one of 3 multi-institutional trials. Median audiogram follow-up was 56 months for protons and 66 months for photons. RESULTS: Mean cochlear dose (Dmc) was lower in patients ...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 17, 2018 Category: Radiology Authors: Paulino AC, Mahajan A, Ye R, Grosshans DR, Fatih Okcu M, Su J, McAleer MF, McGovern S, Mangona VA, Chintagumpala M Tags: Radiother Oncol Source Type: research

Treatment outcome and prognostic factors for adult patients with medulloblastoma: The Rare Cancer Network (RCN) experience.
CONCLUSIONS: Patients with high KPS who received CSI had better rates of disease-free and overall survival. Chemotherapy was associated with better local control. These results may serve as a benchmark for future studies designed to improve outcomes for adults with medulloblastoma. PMID: 29373196 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 17, 2018 Category: Radiology Authors: Atalar B, Ozsahin M, Call J, Napieralska A, Kamer S, Villa S, Erpolat P, Negretti L, Lassen-Ramshad Y, Onal C, Akyurek S, Ugurluer G, Baumert BG, Servagi-Vernat S, Miller RC, Ozyar E, Sio TT Tags: Radiother Oncol Source Type: research

Differences in lung injury after IMRT or proton therapy assessed by 18FDG PET imaging.
CONCLUSIONS: Despite significantly different dose distributions for IMRT and for protons, the slope of the SUV-dose linear regression line previously shown to be associated with RP did not differ between IMRT and protons. Patients who developed radiation pneumonitis had statistically significantly higher MLD and higher slope regardless of treatment modality. PMID: 29352608 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 15, 2018 Category: Radiology Authors: Shusharina N, Liao Z, Mohan R, Liu A, Niemierko A, Choi N, Bortfeld T Tags: Radiother Oncol Source Type: research

Monitoring early changes in rectal tumor morphology and volume during 5  weeks of preoperative chemoradiotherapy - An evaluation with sequential MRIs.
CONCLUSION: Results of this exploratory pilot study suggest that changes in rectal tumor morphology (fibrosis) and volume can already be observed early during radiation, both when measured quantitatively and when assessed visually. These changes appear to be indicative of the final treatment outcome. PMID: 29343409 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 15, 2018 Category: Radiology Authors: Lambregts DMJ, Yassien AB, Lahaye MJ, Betgen A, Maas M, Beets GL, van der Heide UA, van Triest B, Beets-Tan RGH Tags: Radiother Oncol Source Type: research

Response to 'Perilesional edema in brain cancer: Independent prognosticator or epiphenomenon of biomolecular signature?'
PMID: 29343408 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 14, 2018 Category: Radiology Authors: Liang HT, Tseng WI Tags: Radiother Oncol Source Type: research

Standard whole prostate gland radiotherapy with and without lesion boost in prostate cancer: Toxicity in the FLAME randomized controlled trial.
CONCLUSIONS: In intermediate- and high-risk prostate cancer patients, focal dose escalation integrated with standard EBRT did not result in an increase in GU and GI toxicity when compared to the standard treatment up to two years after treatment. This suggests that the described focal dose escalation technique is safe and feasible. PMID: 29336835 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 11, 2018 Category: Radiology Authors: Monninkhof EM, van Loon JWL, van Vulpen M, Kerkmeijer LGW, Pos FJ, Haustermans K, van den Bergh L, Isebaert S, McColl GM, Jan Smeenk R, Noteboom J, Walraven I, Peeters PHM, van der Heide UA Tags: Radiother Oncol Source Type: research

Perilesional edema in brain cancer: Independent prognosticator or epiphenomenon of biomolecular signature?
PMID: 29331541 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 10, 2018 Category: Radiology Authors: Nardone V, Vinciguerra C, Federico A, Cerase A, Pirtoli L, Tini P Tags: Radiother Oncol Source Type: research

Concurrent chemoradiotherapy alone is feasible for esophageal squamous cell carcinoma patients not suitable for surgery.
PMID: 29331542 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 10, 2018 Category: Radiology Authors: Chen Y, Wang J Tags: Radiother Oncol Source Type: research

Consolidation chemotherapy after definite concurrent chemoradiation in patients with non-operable esophageal cancer: Is it useful?
PMID: 29331543 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 10, 2018 Category: Radiology Authors: Adenis A, Castan F, Conroy T Tags: Radiother Oncol Source Type: research

Letter to the Editor on Nevens et al.
PMID: 29317113 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 6, 2018 Category: Radiology Authors: Elicin O, Giger R Tags: Radiother Oncol Source Type: research

Proton beam therapy for skull base chordomas in 106 patients: A dose adaptive radiation protocol.
CONCLUSIONS: This study suggests that the probability of LC of skull base chordomas depends on postoperative GTV. The dose adaptive protocol achieves acceptable local control. Future studies should investigate whether further dose escalation to doses in excess of 74 Gy(RBE) would achieve better results. PMID: 29310903 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 6, 2018 Category: Radiology Authors: Fung V, Calugaru V, Bolle S, Mammar H, Alapetite C, Maingon P, De Marzi L, Froelich S, Habrand JL, Dendale R, Noël G, Feuvret L Tags: Radiother Oncol Source Type: research

Upfront vs. no upfront neck dissection in primary head and neck cancer radio(chemo)therapy: Reply to Elicin et al.
PMID: 29307729 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 4, 2018 Category: Radiology Authors: Nevens D, Duprez F, Bonte K, Deron P, Huvenne W, Laenen A, De Neve W, Nuyts S Tags: Radiother Oncol Source Type: research

Short- and long-term risks of cardiovascular disease following radiotherapy in rectal cancer in four randomized controlled trials and a population-based register.
DISCUSSION: Preoperative radiotherapy did not affect rectal cancer patients' risk of CVD overall. Although an excess risk of short-term venous thromboembolism was noted, the small increase in absolute numbers does not call for general changes in routine prophylactic treatment, but might do so for patients already at high risk of venous thromboembolism. PMID: 29306497 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 3, 2018 Category: Radiology Authors: Chen L, Eloranta S, Martling A, Glimelius I, Neovius M, Glimelius B, Smedby KE Tags: Radiother Oncol Source Type: research

Concurrent chemoradiotherapy for bladder cancer: Practice patterns and outcomes in the general population.
We describe uptake of CRT and comparative effectiveness in routine practice. METHODS: Electronic treatment records were linked to the population-based Ontario Cancer Registry to identify all patients with bladder cancer treated with curative-intent RT in 1999-2013. Modified Poisson regression was used to analyze factors associated with use of CRT. Cox model and propensity score analyses were used to explore factors associated with cancer-specific (CSS) and overall survival (OS). RESULTS: 1192 patients underwent RT during 1999-2013; median age was 79. Use of CRT increased over time: 36% (124/341) in 1999-2003, 38%...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 3, 2018 Category: Radiology Authors: Ghate K, Brennan K, Karim S, Siemens DR, Mackillop WJ, Booth CM Tags: Radiother Oncol Source Type: research

Comparison of detection methods for HPV status as a prognostic marker for loco-regional control after radiochemotherapy in patients with HNSCC.
Baretton GB, Buchholz F, Krause M, Belka C, Baumann M, DKTK-ROG Abstract OBJECTIVE: To compare six HPV detection methods in pre-treatment FFPE tumour samples from patients with locally advanced head and neck squamous cell carcinoma (HNSCC) who received postoperative (N = 175) or primary (N = 90) radiochemotherapy. MATERIALS AND METHODS: HPV analyses included detection of (i) HPV16 E6/E7 RNA, (ii) HPV16 DNA (PCR-based arrays, A-PCR), (iii) HPV DNA (GP5+/GP6+ qPCR, (GP-PCR)), (iv) p16 (immunohistochemistry, p16 IHC), (v) combining p16 IHC and the A-PCR result and (vi) combining p16 IHC and the GP-PCR r...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 30, 2017 Category: Radiology Authors: Linge A, Schötz U, Löck S, Lohaus F, Neubeck CV, Gudziol V, Nowak A, Tinhofer I, Budach V, Sak A, Stuschke M, Balermpas P, Rödel C, Bunea H, Grosu AL, Abdollahi A, Debus J, Ganswindt U, Lauber K, Pigorsch S, Combs SE, Mönnich D, Zips D, Baretton GB, B Tags: Radiother Oncol Source Type: research

Hypofractionated radiation therapy (HFRT) versus conventional fractionated radiation therapy (CRT) for newly diagnosed glioblastoma patients. A propensity score matched analysis.
CONCLUSIONS: A short course of radiation therapy would seem comparable to CRT in terms of outcome and less burdensome for these poor prognosis patients. PMID: 29291951 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 29, 2017 Category: Radiology Authors: Navarria P, Pessina F, Franzese C, Tomatis S, Perrino M, Cozzi L, Simonelli M, Bello L, Clerici E, Riva M, Santoro A, Scorsetti M Tags: Radiother Oncol Source Type: research

CT ventilation imaging derived from breath hold CT exhibits good regional accuracy with Galligas PET.
CONCLUSIONS: High quality CT imaging is a key requirement for accurate CT ventilation imaging. The use of exhale/inhale BHCT can improve the accuracy of CTVI for human subjects. PMID: 29290405 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 28, 2017 Category: Radiology Authors: Eslick EM, Kipritidis J, Gradinscak D, Stevens MJ, Bailey DL, Harris B, Booth JT, Keall PJ Tags: Radiother Oncol Source Type: research

Response to Stephane Renaud et al.
PMID: 29287737 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 26, 2017 Category: Radiology Authors: Yang WC, Shih JY, Ho CC, Hsu FM Tags: Radiother Oncol Source Type: research

MRI evaluation of sacral chordoma treated with carbon ion radiotherapy alone.
Abstract BACKGROUND AND PURPOSE: To compare RECIST 1.1 with volume modifications in patients with sacral chordoma not suitable for surgery treated with carbon ions radiotherapy (CIRT) alone. To evaluate patients pain before and after CIRT. To detect if baseline Apparent Diffusion Coefficient values (ADC) from Diffusion Weighted sequences could predict response to treatment. MATERIAL AND METHODS: Patients included had one cycle of CIRT and underwent MRI before and after treatment. For each MRI, lesion maximum diameter and volume were obtained, and ADC values were analyzed within the whole lesion volume. Patien...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 23, 2017 Category: Radiology Authors: Preda L, Stoppa D, Fiore MR, Fontana G, Camisa S, Sacchi R, Ghitti M, Viselner G, Fossati P, Valvo F, Vitolo V, Bonora M, Iannalfi A, Vischioni B, Vai A, Mastella E, Baroni G, Orecchia R Tags: Radiother Oncol Source Type: research

Phase I trial of stereotactic MR-guided online adaptive radiation therapy (SMART) for the treatment of oligometastatic or unresectable primary malignancies of the abdomen.
Abstract PURPOSE/OBJECTIVES: SBRT is used to treat oligometastatic or unresectable primary abdominal malignancies, although ablative dose delivery is limited by proximity of organs-at-risk (OAR). Stereotactic, magnetic resonance (MR)-guided online-adaptive radiotherapy (SMART) may improve SBRT's therapeutic ratio. This prospective Phase I trial assessed feasibility and potential advantages of SMART to treat abdominal malignancies. MATERIALS/METHODS: Twenty patients with oligometastatic or unresectable primary liver (n = 10) and non-liver (n = 10) abdominal malignancies underwent SMART. Initial plans p...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 22, 2017 Category: Radiology Authors: Henke L, Kashani R, Robinson C, Curcuru A, DeWees T, Bradley J, Green O, Michalski J, Mutic S, Parikh P, Olsen J Tags: Radiother Oncol Source Type: research

Treatment of advanced nasopharyngeal cancer using low- or high-dose concurrent chemoradiotherapy with intensity-modulated radiotherapy: A propensity score-matched, nationwide, population-based cohort study.
CONCLUSION: LD-CCRT or HD-CCRT with IMRT can be a standard treatment that can prolong the survival of patients with advanced NPC. PMID: 29277447 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 22, 2017 Category: Radiology Authors: Chen TM, Lin KC, Yuan KS, Chang CL, Chow JM, Wu SY Tags: Radiother Oncol Source Type: research

Predicting hypoxia status using a combination of contrast-enhanced computed tomography and [18F]-Fluorodeoxyglucose positron emission tomography radiomics features.
CONCLUSION: A radiomics signature built from 18F-FDG PET and contrast-enhanced CT features correlates with 18F-FMISO TBRmax in head and neck cancer patients, providing significantly better performance with respect to models based on 18F-FDG PET only. Such a biomarker could potentially be useful to personalize head and neck cancer treatment at centers for which dedicated hypoxia imaging PET radiotracers are unavailable. PMID: 29273260 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 19, 2017 Category: Radiology Authors: Crispin-Ortuzar M, Apte A, Grkovski M, Oh JH, Lee NY, Schöder H, Humm JL, Deasy JO Tags: Radiother Oncol Source Type: research

Genotype-driven phase I study of weekly irinotecan in combination with capecitabine-based neoadjuvant chemoradiation for locally advanced rectal cancer.
CONCLUSION: A higher dose of weekly irinotecan in combination with capecitabine-based CRT is feasible under the guidance of the UGT1A1∗28 genotype. Further clinical trials at these dose levels are warranted. PMID: 29273261 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 19, 2017 Category: Radiology Authors: Zhu J, Li X, Shen Y, Guan Y, Gu W, Lian P, Sheng W, Cai S, Zhang Z Tags: Radiother Oncol Source Type: research

Long-term quality of life in inoperable non-small cell lung cancer patients treated with conventionally fractionated compared to hyperfractionated accelerated radiotherapy - Results of the randomized CHARTWEL trial.
CONCLUSIONS: Over three years, QoL was similar or more favorable under CHARTWEL compared to CF. Modeling QoL together with disease states provided additional insight into treatment comparisons. PMID: 29273262 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 19, 2017 Category: Radiology Authors: Hechtner M, Krause M, König J, Appold S, Hornemann B, Singer S, Baumann M Tags: Radiother Oncol Source Type: research

ESTRO ACROP: Technology for precision small animal radiotherapy research: Optimal use and challenges.
This report discusses the combination of precision irradiation systems, small animal imaging (CT, MRI, PET, SPECT, bioluminescence) systems, image registration, treatment planning, and data processing. It also provides guidelines for reporting on studies. PMID: 29269093 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 18, 2017 Category: Radiology Authors: Verhaegen F, Dubois L, Gianolini S, Hill MA, Karger CP, Lauber K, Prise KM, Sarrut D, Thorwarth D, Vanhove C, Vojnovic B, Weersink R, Wilkens JJ, Georg D Tags: Radiother Oncol Source Type: research

Prospect of robotic assistance for fully automated brachytherapy seed placement into skull base: Experimental validation in phantom and cadaver.
Abstract BACKGROUND AND PURPOSE: To investigate the feasibility and accuracy of robot-assisted brachytherapy for skull base tumours. MATERIAL AND METHODS: A custom robot system was tested on both phantom and cadaveric specimen. Cone beam CT (CBCT) images were transferred to the graphical user interface (GUI) for planning trajectories and the data were sent to the robot control unit. Following registration, the puncture needle was inserted into the target by the robot under navigation guidance, and seeds were implanted. Placement error was instantly displayed on the GUI; the result was verified after postopera...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 18, 2017 Category: Radiology Authors: Zhu JH, Wang J, Wang YG, Li M, Liu XJ, Guo CB Tags: Radiother Oncol Source Type: research

Systematic intrafraction shifts of mediastinal lymph node targets between setup imaging and radiation treatment delivery in lung cancer patients.
CONCLUSIONS: Systematic cranial and posterior intrafraction baseline shifts between CBCT and treatment delivery were observed for mediastinal LN targets. Intrafraction motion amplitudes were stable. PMID: 29258694 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 16, 2017 Category: Radiology Authors: Schmidt ML, Hoffmann L, Møller DS, Knap MM, Rasmussen TR, Folkersen BH, Poulsen PR Tags: Radiother Oncol Source Type: research

Nomogram to predict the benefit of additional induction chemotherapy to concurrent chemoradiotherapy in locoregionally advanced nasopharyngeal carcinoma: Analysis of a multicenter, phase III randomized trial.
CONCLUSION: We developed a convenient nomogram to estimate the benefit of IC for individual patients with LANPC. This tool can serve as a catalyst of individual treatment discussions and facilitator of informed decision-making. PMID: 29258695 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 16, 2017 Category: Radiology Authors: Zhang Y, Li WF, Liu X, Chen L, Sun R, Sun Y, Liu Q, Ma J Tags: Radiother Oncol Source Type: research