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Radio-chemotherapy of glioblastoma cells promotes phagocytosis by macrophages in vitro
CONCLUSIONS: and Perspectives We showed that macrophage phagocytic activity increased when exposed to supernatant from GBM cells treated by radio-chemotherapy. However, as efferocytosis-associated receptors were up-regulated, this effect could be deleterious for the anti-GBM immune response. We speculate that by inducing GBM cell apoptosis in parallel to an increase in efferocytosis receptor expression, the impact of radio-chemotherapy on phagocytic activity could promote anti-inflammatory and pro-tumoral TAM functions.PMID:38072365 | DOI:10.1016/j.radonc.2023.110049 (Source: Radiotherapy and Oncology : journal of the Euro...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 10, 2023 Category: Radiology Authors: Marc Lecoultre Sylvie Chliate Felipe I Espinoza Stoyan Tankov Val érie Dutoit Paul R Walker Source Type: research

Radio-chemotherapy of glioblastoma cells promotes phagocytosis by macrophages in vitro
CONCLUSIONS: and Perspectives We showed that macrophage phagocytic activity increased when exposed to supernatant from GBM cells treated by radio-chemotherapy. However, as efferocytosis-associated receptors were up-regulated, this effect could be deleterious for the anti-GBM immune response. We speculate that by inducing GBM cell apoptosis in parallel to an increase in efferocytosis receptor expression, the impact of radio-chemotherapy on phagocytic activity could promote anti-inflammatory and pro-tumoral TAM functions.PMID:38072365 | DOI:10.1016/j.radonc.2023.110049 (Source: Radiotherapy and Oncology : journal of the Euro...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 10, 2023 Category: Radiology Authors: Marc Lecoultre Sylvie Chliate Felipe I Espinoza Stoyan Tankov Val érie Dutoit Paul R Walker Source Type: research

Integration of dosimetric parameters, clinical factors, and radiomics to predict symptomatic radiation pneumonitis in lung cancer patients undergoing combined immunotherapy and radiotherapy
CONCLUSIONS: In patients undergoing combined immunotherapy/RT for lung cancer, integrating clinical/dosimetric factors and handcrafted/deep learning radiomic features can offer a high predictive capacity for RP, and merits further prospective validation.PMID:38070685 | DOI:10.1016/j.radonc.2023.110047 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 9, 2023 Category: Radiology Authors: Tingting Nie Zien Chen Jun Cai Shuangquan Ai Xudong Xue Mengting Yuan Chao Li Liting Shi Yulin Liu Vivek Verma Jianping Bi Guang Han Zilong Yuan Source Type: research

Radiotherapy to reinvigorate immunotherapy activity after acquired resistance in metastatic non-small-cell lung cancer: A pooled analysis of two institutions prospective phase II single arm trials
CONCLUSIONS: The current pooled analysis is a prospective evaluation of the role of radiation therapy for metastatic NSCLC in the setting of newly acquired immunotherapy resistance. Hypofractionated radiotherapy can support the outcome of immune checkpoint inhibitors and thus allow continuation of treatment for a relevant amount of time despite initial tumor progression.PMID:38070686 | DOI:10.1016/j.radonc.2023.110048 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 9, 2023 Category: Radiology Authors: Ilinca Popp Rianne D W Vaes Lotte Wieten Sonja Adebahr Lizza Hendriks Elham Bavafaye Haghighi Juliette Degens Henning Sch äfer Christine Greil St éphanie Peeters Cornelius F Waller Ruud Houben Gabriele Niedermann Justyna Rawluk Eleni Gkika Justus Duyste Source Type: research

Reproducibility of diffusion-weighted magnetic resonance imaging in head and neck cancer assessed on a 1.5 T MR-Linac and comparison to parallel measurements on a 3 T diagnostic scanner
CONCLUSION: ADC values, measured on the 1.5 T MRL, showed reasonable reproducibility with an ADC underestimation in contrast to the DS. This ADC shift must be validated in further experiments and considered for future translation of QIB candidates from DS to MRL for response adaptive RT.PMID:38070687 | DOI:10.1016/j.radonc.2023.110046 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 9, 2023 Category: Radiology Authors: Jonas Habrich Simon Boeke Victor Fritz Elisa Koerner Konstantin Nikolaou Fritz Schick Cihan Gani Daniel Zips Daniela Thorwarth Source Type: research