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Pre- and per-treatment 18F-FDG PET/CT parameters to predict recurrence and survival in cervical cancer.
CONCLUSIONS: MTV and TLG calculated with a threshold of 55% SUVmax and 32% SUVmax from pre- and per-treatment PET scans respectively, can be used to predict patient outcome after CCRT for LACC. PMID: 27569847 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - August 25, 2016 Category: Radiology Authors: Leseur J, Roman-Jimenez G, Devillers A, Ospina-Arango JD, Williaume D, Castelli J, Terve P, Lavoue V, Garin E, Lejeune F, Acosta O, De Crevoisier R Tags: Radiother Oncol Source Type: research

Stereotactic body radiotherapy for primary hepatic malignancies - Report of a phase I/II institutional study.
CONCLUSIONS: Primary hepatic malignancies not amenable to surgical resection portend a poor prognosis, despite available treatment options. Though radiation-induced liver disease (RILD) is rare following SBRT, this study demonstrates a risk of hepatic failure despite adherence to protocol constraints. PMID: 27566894 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - August 23, 2016 Category: Radiology Authors: Weiner AA, Olsen J, Ma D, Dyk P, DeWees T, Myerson RJ, Parikh P Tags: Radiother Oncol Source Type: research

Bayesian regression analyses of radiation modality effects on pericardial and pleural effusion and survival in esophageal cancer.
CONCLUSIONS: IMRT reduces the incidence and postpones the onset of PCE and PE, and increases survival probability, compared to 3DCRT. PMID: 27562616 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - August 22, 2016 Category: Radiology Authors: He L, Chapple A, Liao Z, Komaki R, Thall PF, Lin SH Tags: Radiother Oncol Source Type: research

Image Guided Adaptive Brachytherapy in cervix cancer: A new paradigm changing clinical practice and outcome.
;tter R PMID: 27555228 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - August 20, 2016 Category: Radiology Authors: Tanderup K, Lindegaard JC, Kirisits C, Haie-Meder C, Kirchheiner K, de Leeuw A, Jürgenliemk-Schulz I, Van Limbergen E, Pötter R Tags: Radiother Oncol Source Type: research

Fiducial marker guided stereotactic liver radiotherapy: Is a time delay between marker implantation and planning CT needed?
This study found that such a delay is unnecessary and could be avoided to minimize the treatment preparation time. PMID: 27555229 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - August 20, 2016 Category: Radiology Authors: Worm ES, Bertholet J, Høyer M, Fledelius W, Hansen AT, Larsen LP, Nielsen JE, Poulsen PR Tags: Radiother Oncol Source Type: research

Multicatheter interstitial brachytherapy versus intensity modulated external beam therapy for accelerated partial breast irradiation: A comparative treatment planning study with respect to dosimetry of organs at risk.
CONCLUSIONS: The target volume can be appropriately irradiated by both techniques, but MIBT generally spares normal tissues and organs at risk better than IMRT. Except for the heart, other critical structures receive less doses with brachytherapy. To observe whether these dosimetric findings translate into clinical outcome more studies are needed with assessment of toxicity profiles. PMID: 27544819 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - August 17, 2016 Category: Radiology Authors: Major T, Stelczer G, Pesznyák C, Mészáros N, Polgár C Tags: Radiother Oncol Source Type: research

Impact of pre- and early per-treatment FDG-PET based dose-escalation on local tumour control in fractionated irradiated FaDu xenograft tumours.
umann B Abstract OBJECTIVE: To investigate local tumour control after dose-escalation based on [(18)F]2-fluoro-2-deoxy-d-glucose (FDG) positron emission tomography (PET) obtained before and early during fractionated irradiation. MATERIALS AND METHODS: 85 mice bearing FaDu xenografts underwent FDG-PET twice: first immediately prior to the first 2-Gy fraction of irradiation (PET1_0) and second after 18°Gy (PET2_18). After these 9 fractions, animals were randomly allocated to: (1) continuation of 2-Gy fractions (cumulative dose of 60°Gy; n=31), (2) dose-escalation with 3-Gy fractions (cumulative EQD2-dos...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - August 17, 2016 Category: Radiology Authors: Jentsch C, Bergmann R, Brüchner K, Mosch B, Yaromina A, Krause M, Zips D, Troost EG, Löck S, Kotzerke J, Steinbach J, Thames H, Baumann M, Beuthien-Baumann B Tags: Radiother Oncol Source Type: research

Plan selection strategy for rectum cancer patients: An interobserver study to assess clinical feasibility.
CONCLUSION: With a plan selection consistency between observers of 75%, a plan selection strategy for rectum cancer patients is feasible. PMID: 27543254 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - August 16, 2016 Category: Radiology Authors: de Jong R, Lutkenhaus L, van Wieringen N, Visser J, Wiersma J, Crama K, Geijsen D, Bel A Tags: Radiother Oncol Source Type: research

Local control dependence on consecutive vs. nonconsecutive fractionation in lung stereotactic body radiation therapy.
CONCLUSION: Five-fraction SBRT delivered over non-consecutive days imparts superior LC and similar toxicity compared to consecutive fractionation. These results should be validated in independent datasets and in a prospective fashion. PMID: 27543255 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - August 16, 2016 Category: Radiology Authors: Alite F, Stang K, Balasubramanian N, Adams W, Shaikh MP, Small C, Sethi A, Nagda S, Emami B, Harkenrider MM Tags: Radiother Oncol Source Type: research

The accuracy of extracted target motion trajectories in four-dimensional cone-beam computed tomography for lung cancer patients.
CONCLUSIONS: This study showed the magnitude of underestimation toward the inferior direction of target motion in clinical 4D-CBCT. PMID: 27528116 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - August 12, 2016 Category: Radiology Authors: Iramina H, Nakamura M, Iizuka Y, Mitsuyoshi T, Matsuo Y, Mizowaki T, Hiraoka M, Kanno I Tags: Radiother Oncol Source Type: research

Oligometastatic bone disease in prostate cancer patients treated on the TROG 03.04 RADAR trial.
CONCLUSION: Randomised trials are essential to determine the value of extirpative treatment for oligometastatic bony metastases due to PC. PMID: 27528117 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - August 12, 2016 Category: Radiology Authors: Sridharan S, Steigler A, Spry NA, Joseph D, Lamb DS, Matthews JH, Atkinson C, Tai KH, Duchesne G, Christie D, Attia J, Holliday EG, Denham JW Tags: Radiother Oncol Source Type: research

Reduction of the dose of radiotherapy to the elective neck in head and neck squamous cell carcinoma; a randomized clinical trial. Effect on late toxicity and tumor control.
CONCLUSIONS: In our study population there was no statistically significant difference regarding survival and estimated recurrence rates between both arms of this study. We found a trend toward less dysphagia at 6months (however not significant after longitudinal analysis) and found a significant reduction of any salivary gland toxicity at 6 and 18months in the 40Gy arm. PMID: 27528118 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - August 12, 2016 Category: Radiology Authors: Nevens D, Duprez F, Daisne JF, Dok R, Belmans A, Voordeckers M, Van den Weyngaert D, De Neve W, Nuyts S Tags: Radiother Oncol Source Type: research

Impact of organ shape variations on margin concepts for cervix cancer ART.
CONCLUSION: PTVART Library achieved the best dosimetric results. However when weighing clinical benefit against workload, ITV margins based on repetitive movement evaluation during the first week also provide improvements over static margin concepts. PMID: 27528119 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - August 12, 2016 Category: Radiology Authors: Seppenwoolde Y, Stock M, Buschmann M, Georg D, Bauer-Novotny KY, Pötter R, Georg P Tags: Radiother Oncol Source Type: research

A prospective study of DWI, DCE-MRI and FDG PET imaging for target delineation in brachytherapy for cervical cancer.
CONCLUSIONS: DWI/DCE-MRI/FDG-PET imaging as a supplement to T2w MRI decreased interobserver variability in GTVB delineation. PMID: 27528120 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - August 12, 2016 Category: Radiology Authors: Han K, Croke J, Foltz W, Metser U, Xie J, Shek T, Driscoll B, Ménard C, Vines D, Coolens C, Simeonov A, Beiki-Ardakani A, Leung E, Levin W, Fyles A, Milosevic MF Tags: Radiother Oncol Source Type: research

International consensus guidelines on Clinical Target Volume delineation in rectal cancer.
CONCLUSION: The definition of international CG for RC delineation endorsed by international experts might support a future homogeneous comparison between clinical trial outcomes. PMID: 27528121 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - August 12, 2016 Category: Radiology Authors: Valentini V, Gambacorta MA, Barbaro B, Chiloiro G, Coco C, Das P, Fanfani F, Joye I, Kachnic L, Maingon P, Marijnen C, Ngan S, Haustermans K Tags: Radiother Oncol Source Type: research

Lack of clinical evidence for postoperative radiotherapy after surgical fixation of impending or actual pathologic fractures in the long bones in patients with cancer; a systematic review.
Abstract Patients with disseminated cancer and bone metastases have a limited life expectancy and therefore any treatment should have a clear beneficial effect, outweighing all possible downsides. This systematic review aims to identify and evaluate available evidence regarding function, pain, quality of life, survival and complications of postoperative radiotherapy (RT) after surgical stabilization of impending or actual pathologic fractures of the long bones due to bone metastases. A literature search resulted in two articles reporting on 64 and 110 patients of whom 55% and 28% received postoperative RT, respect...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - August 11, 2016 Category: Radiology Authors: Willeumier JJ, van der Linden YM, Dijkstra PD Tags: Radiother Oncol Source Type: research

Stage III Non-Small Cell Lung Cancer in the elderly: Patient characteristics predictive for tolerance and survival of chemoradiation in daily clinical practice.
CONCLUSION: Although relatively fit elderly were assigned to cCHRT, treatment tolerance was worse, especially for those with severe comorbidity. Survival seemed not significantly better as compared to sCHRT or RT. Prospective studies in this vital and understudied area are needed. PMID: 27522577 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - August 10, 2016 Category: Radiology Authors: Driessen EJ, Bootsma GP, Hendriks LE, van den Berkmortel FW, Bogaarts BA, van Loon JG, Dingemans AC, Janssen-Heijnen ML Tags: Radiother Oncol Source Type: research

Conformity analysis to demonstrate reproducibility of target volumes for Margin-Intense Stereotactic Radiotherapy for borderline-resectable pancreatic cancer.
CONCLUSIONS: Better conformity with reference was shown for boost volume compared with GTV. Investigator GTV volumes were larger than reference, had higher DI scores and modelled toxicity risk. A consistent method of target structure definition for margin-directed pancreatic radiotherapy is demonstrated. PMID: 27519585 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - August 9, 2016 Category: Radiology Authors: Holyoake DL, Robinson M, Grose D, McIntosh D, Sebag-Montefiore D, Radhakrishna G, Patel N, Partridge M, Mukherjee S, Hawkins MA Tags: Radiother Oncol Source Type: research

The use of deformable image registration to integrate diagnostic MRI into the radiotherapy planning pathway for head and neck cancer.
CONCLUSIONS: Contouring on MRI-RT rigidly registered to pCT should be considered as the gold standard for HNSCC. In radiotherapy centres lacking a dedicated MRI-RT, the use of an MRI-D with DIR-whole offers a significant advantage for the accuracy of GTV delineation over contouring on pCT alone. PMID: 27497803 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - August 3, 2016 Category: Radiology Authors: Chuter R, Prestwich R, Bird D, Scarsbrook A, Sykes J, Wilson D, Speight R Tags: Radiother Oncol Source Type: research

Comparison of investigator-delineated gross tumour volumes and quality assurance in pancreatic cancer: Analysis of the on-trial cases for the SCALOP trial.
CONCLUSIONS: Radiotherapy workshops and real-time central review of contours are required in RT trials of pancreatic cancer. PMID: 27497804 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - August 3, 2016 Category: Radiology Authors: Fokas E, Spezi E, Patel N, Hurt C, Nixon L, Chu KY, Staffurth J, Abrams R, Mukherjee S Tags: Radiother Oncol Source Type: research

Immune modulation by hypofractionated stereotactic radiation therapy: Therapeutic implications.
Abstract Stereotactic body radiation therapy (SBRT) has become an attractive treatment modality and a safe, non-invasive alternative to surgery to control primary or secondary malignant tumors. While emphasis has been on the local tumor control as a treatment objective for SBRT, the rare but intriguing observations of abscopal (or out-of-field) effects have pointed to the exciting possibility of activating anti-tumor immunity by using high-dose radiation. This review summarizes the available evidence supporting immune modulation by SBRT alone, as well as its potential combination with immunotherapy. Promising prec...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - August 2, 2016 Category: Radiology Authors: Popp I, Grosu AL, Niedermann G, Duda DG Tags: Radiother Oncol Source Type: research

Cardiac and respiration induced motion of mediastinal lymph node targets in lung cancer patients throughout the radiotherapy treatment course.
CONCLUSIONS: Detailed mapping showed that LN motion was in general governed by breathing, but some LNs had substantial cardiac induced motion. PMID: 27492202 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - August 2, 2016 Category: Radiology Authors: Schmidt ML, Hoffmann L, Knap MM, Rasmussen TR, Folkersen BH, Toftegaard J, Møller DS, Poulsen PR Tags: Radiother Oncol Source Type: research

Post radiation hysterectomy in locally advanced cervical cancer: Outcomes and dosimetric impact.
CONCLUSION: No benefit from completion hysterectomy in terms of overall or disease-free survival rates was observed, which was moreover responsible for an increase of the severe late morbidity. The realization of post-radiation hysterectomy resulted in a shift of the ED10 of 24.1Gy. PMID: 27492204 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - August 2, 2016 Category: Radiology Authors: Mazeron R, Gouy S, Chargari C, Rivin Del Campo E, Dumas I, Mervoyer A, Genestie C, Bentivegna E, Balleyguier C, Pautier P, Morice P, Haie-Meder C Tags: Radiother Oncol Source Type: research

Comparative evaluation of respiratory-gated and ungated FDG-PET for target volume definition in radiotherapy treatment planning for pancreatic cancer.
CONCLUSION: The ITV generated from 4D-PET can be used to improve the accuracy or reduce normal tissue irradiation compared with conventional un-gated PET-based ITV. PMID: 27492203 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - August 1, 2016 Category: Radiology Authors: Kishi T, Matsuo Y, Nakamura A, Nakamoto Y, Itasaka S, Mizowaki T, Togashi K, Hiraoka M Tags: Radiother Oncol Source Type: research

Non-coplanar trajectories to improve organ at risk sparing in volumetric modulated arc therapy for primary brain tumors.
CONCLUSIONS: The geometric heuristic technique best spared OARs and reduced normal tissue complication probability, however incorporating fluence information into non-coplanar trajectory optimization maintained PTV homogeneity. PMID: 27481571 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 29, 2016 Category: Radiology Authors: Smyth G, Evans PM, Bamber JC, Mandeville HC, Welsh LC, Saran FH, Bedford JL Tags: Radiother Oncol Source Type: research

Diffusion-weighted magnetic resonance imaging for evaluation of salivary gland function in head and neck cancer patients treated with intensity-modulated radiotherapy.
CONCLUSIONS: DW-MRI seems a promising tool for detection of physiological and functional changes in major salivary glands after RT. PMID: 27475276 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 27, 2016 Category: Radiology Authors: Loimu V, Seppälä T, Kapanen M, Tuomikoski L, Nurmi H, Mäkitie A, Tenhunen M, Saarilahti K Tags: Radiother Oncol Source Type: research

Skin cancer of the head and neck with gross or microscopic perineural involvement: Patterns of failure.
CONCLUSIONS: In patients with GCNI radiotherapy achieves a substantial chance of disease control. Radiotherapy to nerves at risk in MFPNI did not affect outcome, but in MEPNI it achieved less gross perineural recurrences and better DFS, compared with observation. PMID: 27475277 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 27, 2016 Category: Radiology Authors: Sapir E, Tolpadi A, McHugh J, Samuels SE, Elalfy E, Spector M, Shuman AG, Malloy KM, Prince ME, Bradford CR, Worden FP, Schipper M, Eisbruch A Tags: Radiother Oncol Source Type: research

Clinical implementation of 3D printing in the construction of patient specific bolus for electron beam radiotherapy for non-melanoma skin cancer.
CONCLUSIONS: The implemented workflow is feasible, patient friendly, safe, and results in high quality dose distributions. This new technique increases time efficiency. PMID: 27475278 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 27, 2016 Category: Radiology Authors: Canters RA, Lips IM, Wendling M, Kusters M, van Zeeland M, Gerritsen RM, Poortmans P, Verhoef CG Tags: Radiother Oncol Source Type: research

10-Year follow-up of 621 patients treated using high-dose rate brachytherapy as ambulatory boost technique in conservative breast cancer treatment.
This study sought to evaluate local control and cosmetic results of delivering boost doses using a high-dose-rate (HDR) brachytherapy (HDRBT) in breast cancer conservative treatment. METHODS: We included 621 T1-T2, N0-N1 breast cancer patients who underwent lumpectomy, external irradiation (44Gy over 5weeks), and a boost dose of two fractions of 5Gy to the tumor bed by means of HDR iridium brachytherapy. Implantation was performed during the lumpectomy or 2-3weeks after external irradiation. Population characteristics were as follows: pTis=11.6%; pT1=63.4%; pT2=25.0%; median tumor size=1.5cm; histology: ductal carcino...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 26, 2016 Category: Radiology Authors: Quéro L, Guillerm S, Taright N, Michaud S, Teixeira L, Cahen-Doidy L, Bourstyn E, Espié M, Hennequin C Tags: Radiother Oncol Source Type: research

Quality of treatment plans and accuracy of in vivo portal dosimetry in hybrid intensity-modulated radiation therapy and volumetric modulated arc therapy for prostate cancer.
This study investigates the quality of treatment plans and the accuracy of in vivo portal dosimetry in such a hybrid approach for the case of prostate radiotherapy. MATERIAL AND METHODS: Conformal and limited-modulation VMAT plans were produced, together with five hybrid IMRT/VMAT plans, in which 0%, 25%, 50%, 75% or 100% of the segments were sequenced for IMRT, while the remainder were sequenced for VMAT. Integrated portal images were predicted for the plans. The plans were then delivered as a single hybrid beam using an Elekta Synergy accelerator with Agility head to a water-equivalent phantom and treatment time, is...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 25, 2016 Category: Radiology Authors: Bedford JL, Smyth G, Hanson IM, Tree AC, Dearnaley DP, Hansen VN Tags: Radiother Oncol Source Type: research

CT image biomarkers to improve patient-specific prediction of radiation-induced xerostomia and sticky saliva.
CONCLUSION: Prediction of XER12m and STIC12m was improved by including IBMs representing heterogeneity and density of the salivary glands, respectively. These IBMs could guide additional research to the patient-specific response of healthy tissue to radiation dose. PMID: 27459902 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 22, 2016 Category: Radiology Authors: van Dijk LV, Brouwer CL, van der Schaaf A, Burgerhof JG, Beukinga RJ, Langendijk JA, Sijtsema NM, Steenbakkers RJ Tags: Radiother Oncol Source Type: research

A volumetric analysis of GTVD and CTVHR as defined by the GEC ESTRO recommendations in FIGO stage IIB and IIIB cervical cancer patients treated with IGABT in a prospective multicentric trial (EMBRACE).
orative Group Abstract PURPOSE: To quantify the gross tumor volume at diagnosis (GTVD) and high-risk clinical target volume (CTVHR) at brachytherapy (BT) and describe subgroups of patients with different patterns of response to chemoradiotherapy (CRT) in patients with FIGO stage IIB and IIIB cervical cancer treated with image-guided adaptive brachytherapy (IGABT). Additionally, to evaluate the feasibility of IGABT achieving adequate target coverage in these groups. MATERIALS AND METHODS: Patients with FIGO stage IIB and IIIB cervical cancer enrolled in the EMBRACE study were analyzed. T2-weighted MRI scans we...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 21, 2016 Category: Radiology Authors: Jastaniyah N, Yoshida K, Tanderup K, Lindegaard JC, Sturdza A, Kirisits C, Šegedin B, Mahantshetty U, Rai B, Jürgenliemk-Schulz IM, Haie-Meder C, Banerjee S, Pötter R, EMBRACE Collaborative Group Tags: Radiother Oncol Source Type: research

Can reduction of uncertainties in cervix cancer brachytherapy potentially improve clinical outcome?
CONCLUSION: TCP is robust to dosimetric uncertainties when dose prescription is in the more flat region of the dose-response curve at doses>75Gy. For OARs, improved clinical outcome is expected by reduction of uncertainties via sophisticated dose delivery and treatment verification. PMID: 27452410 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 21, 2016 Category: Radiology Authors: Nesvacil N, Tanderup K, Lindegaard JC, Pötter R, Kirisits C Tags: Radiother Oncol Source Type: research

Which cervical and endometrial cancer patients will benefit most from intensity-modulated proton therapy?
Abstract In this dosimetric comparison study it was shown that IMPT with robust planning reduces dose to surrounding organs in cervical and endometrial cancer treatment compared with IMRT. Especially for the para-aortic region, clinically relevant dose reductions were obtained for kidneys, spinal cord and bowel, justifying the use of proton therapy for this indication. PMID: 27452411 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 21, 2016 Category: Radiology Authors: van de Sande MA, Creutzberg CL, van de Water S, Sharfo AW, Hoogeman MS Tags: Radiother Oncol Source Type: research

Quantitative MRI assessment of a novel direction modulated brachytherapy tandem applicator for cervical cancer at 1.5T.
CONCLUSIONS: This work demonstrated that the novel DMBT tandem applicator prototype has minimal artifact in T2-weighted images employed in clinical practice, suggesting the applicator might be a good candidate for MRI-guided adaptive brachytherapy. PMID: 27443448 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 18, 2016 Category: Radiology Authors: Soliman AS, Elzibak A, Easton H, Kim JY, Han DY, Safigholi H, Mashouf S, Owrangi A, Ravi A, Song WY Tags: Radiother Oncol Source Type: research

Individual patient data meta-analysis shows a significant association between the ATM rs1801516 SNP and toxicity after radiotherapy in 5456 breast and prostate cancer patients.
CONCLUSION: This study convincingly showed a significant association between the ATM rs1801516 Asn allele and increased risk of radiation-induced normal tissue toxicity. PMID: 27443449 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 18, 2016 Category: Radiology Authors: Andreassen CN, Rosenstein BS, Kerns SL, Ostrer H, De Ruysscher D, Cesaretti JA, Barnett GC, Dunning AM, Dorling L, West CM, Burnet NG, Elliott R, Coles C, Hall E, Fachal L, Vega A, Gómez-Caamaño A, Talbot CJ, Symonds RP, De Ruyck K, Thierens H, Ost P, C Tags: Radiother Oncol Source Type: research

Liquid fiducial marker performance during radiotherapy of locally advanced non small cell lung cancer.
CONCLUSIONS: The liquid fiducial markers were visible and stable in size and position throughout the treatment course. PMID: 27443450 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 18, 2016 Category: Radiology Authors: Rydhög JS, Mortensen SR, Larsen KR, Clementsen P, Jølck RI, Josipovic M, Aznar MC, Specht L, Andresen TL, Rosenschöld PM, Persson GF Tags: Radiother Oncol Source Type: research

Modelling of organ-specific radiation-induced secondary cancer risks following particle therapy.
CONCLUSION: Based on the wide spread in RR between patients and variations across the included parameter values, the risk profiles of the rectum and bladder were not dramatically different for the investigated radiotherapy techniques. PMID: 27424291 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 13, 2016 Category: Radiology Authors: Stokkevåg CH, Fukahori M, Nomiya T, Matsufuji N, Engeseth GM, Hysing LB, Ytre-Hauge KS, Rørvik E, Szostak A, Muren LP Tags: Radiother Oncol Source Type: research

Diffusion tensor imaging predicts cognitive function change following partial brain radiotherapy for low-grade and benign tumors.
CONCLUSIONS: Imaging biomarkers of white matter injury contributed to predictive models of cognitive function change after RT. PMID: 27418525 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 11, 2016 Category: Radiology Authors: Chapman CH, Zhu T, Nazem-Zadeh M, Tao Y, Buchtel HA, Tsien CI, Lawrence TS, Cao Y Tags: Radiother Oncol Source Type: research

Patient reported quality of life after helical IMRT based concurrent chemoradiation of locally advanced anal cancer.
CONCLUSIONS: Most impaired functions and symptoms following HT based CCRT were temporary and improved by 3months post-therapy. Late complications affecting QOL were FI, sexual function, UI, and diarrhea. Our observations support routine use of IMRT and emphasize the significance of precise evaluation of sexual, urinary, and anorectal functions before starting CCRT and routine incorporation of QOL evaluations. PMID: 27406441 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 9, 2016 Category: Radiology Authors: Joseph K, Vos LJ, Warkentin H, Paulson K, Polkosnik LA, Usmani N, Tankel K, Severin D, Nijjar T, Schiller D, Wong C, Ghosh S, Mulder K, Field C Tags: Radiother Oncol Source Type: research

Estimating the probability of underdosing microscopic brain metastases with hippocampal-sparing whole-brain radiation.
CONCLUSIONS: Our results describe the characteristics of an array of hippocampal-sparing whole-brain radiation dose distributions. These can be used as a decision-making guideline for weighing the benefit of decreased dose to the hippocampi against the cost of decreased dose to potential brain metastases when deciding on a hippocampal-sparing whole-brain irradiation treatment approach. PMID: 27406442 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 9, 2016 Category: Radiology Authors: Chang JS, Perez-Andujar A, Barani IJ, Ma L, Larson DA Tags: Radiother Oncol Source Type: research

PrP(c) deficiency and dasatinib protect mouse intestines against radiation injury by inhibiting of c-Src.
CONCLUSION: Our data are the first to show a role for the PrP(c)-Src pathway in acute intestinal response to radiation injury and offer a novel therapeutic opportunity. PMID: 27406443 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 9, 2016 Category: Radiology Authors: Strup-Perrot C, Vozenin MC, Monceau V, Pouzoulet F, Petit B, Holler V, Perrot S, Desquibert L, Fouquet S, Souquere S, Pierron G, Rousset M, Thenet S, Cardot P, Benderitter M, Deutsch E, Aigueperse J Tags: Radiother Oncol Source Type: research

Metformin for chemo-radio-sensitization of NSCLC.
PMID: 27401403 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 8, 2016 Category: Radiology Authors: Tsakiridis T, Skinner H, Pond G, Swaminath A, Wright J Tags: Radiother Oncol Source Type: research

A comparative planning study for lung SABR between tri-Co-60 magnetic resonance image guided radiation therapy system and volumetric modulated arc therapy.
Abstract BACKGROUND AND PURPOSE: To compare the plan quality of tri-(60)Co magnetic-resonance image-guided radiation therapy (IGRT) to that of volumetric modulated arc therapy (VMAT) for lung stereotactic ablative radiotherapy (SABR). MATERIALS AND METHODS: A total of 22 patients with lung tumors located in the lower lobe were selected retrospectively. For each patient, VMAT plans with linac and intensity-modulated radiation therapy (IMRT) plans with the tri-(60)Co system were generated with prescription doses of 60Gy (daily dose=15Gy). For both plan types, identical CT image sets and structures were used, wi...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 8, 2016 Category: Radiology Authors: Park JM, Park SY, Kim HJ, Wu HG, Carlson J, Kim JI Tags: Radiother Oncol Source Type: research

Dose-volume effect relationships for late rectal morbidity in patients treated with chemoradiation and MRI-guided adaptive brachytherapy for locally advanced cervical cancer: Results from the prospective multicenter EMBRACE study.
llaborative group Abstract PURPOSE: To establish dose volume-effect relationships predicting late rectal morbidity in cervix cancer patients treated with concomitant chemoradiation and MRI-guided adaptive brachytherapy (IBABT) within the prospective EMBRACE study. MATERIAL AND METHOD: All patients were treated with curative intent according to institutional protocols with chemoradiation and IGABT. Reporting followed the GEC-ESTRO recommendations ( [Formula: see text] , [Formula: see text] ), applying bioeffect modeling (linear quadratic model) with equieffective doses (EQD23). Morbidity was scored according t...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 7, 2016 Category: Radiology Authors: Mazeron R, Fokdal LU, Kirchheiner K, Georg P, Jastaniyah N, Šegedin B, Mahantshetty U, Hoskin P, Jürgenliemk-Schulz I, Kirisists C, Lindegaard JC, Dörr W, Haie-Meder C, Tanderup K, Pötter R, EMBRACE collaborative group Tags: Radiother Oncol Source Type: research

Dose prescription in carbon ion radiotherapy: How to compare two different RBE-weighted dose calculation systems.
CONCLUSIONS: Prescription dose conversion factors could minimize target physical dose variations due to the use of different radiobiological models in the calculation of CIRT RBE-weighted dose. PMID: 27394694 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 6, 2016 Category: Radiology Authors: Molinelli S, Magro G, Mairani A, Matsufuji N, Kanematsu N, Inaniwa T, Mirandola A, Russo S, Mastella E, Hasegawa A, Tsuji H, Yamada S, Vischioni B, Vitolo V, Ferrari A, Ciocca M, Kamada T, Tsujii H, Orecchia R, Fossati P Tags: Radiother Oncol Source Type: research

Evaluating inter-campus plan consistency using a knowledge based planning model.
CONCLUSIONS: KBP can retrospectively highlight subtle differences in planning practices, even between campuses of the same institution. This information can be used to identify areas needing increased consistency in planning output and subsequently improve consistency and quality of care. PMID: 27394695 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 6, 2016 Category: Radiology Authors: Berry SL, Ma R, Boczkowski A, Jackson A, Zhang P, Hunt M Tags: Radiother Oncol Source Type: research

Effects of anatomical changes on pencil beam scanning proton plans in locally advanced NSCLC patients.
CONCLUSIONS: Daily anatomical variations over the course of treatment can cause considerable dose differences in the robust planned dose distribution. An advanced planning strategy including knowledge of anatomical uncertainties would be recommended to improve plan robustness against interfractional variations. For large anatomical changes, adaptive therapy is mandatory. PMID: 27393217 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 5, 2016 Category: Radiology Authors: Szeto YZ, Witte MG, van Kranen SR, Sonke JJ, Belderbos J, van Herk M Tags: Radiother Oncol Source Type: research

A randomised controlled trial of Caphosol mouthwash in management of radiation-induced mucositis in head and neck cancer.
CONCLUSION: Caphosol did not reduce the incidence or duration of severe OM during and after radiotherapy in HNC. PMID: 27393218 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 5, 2016 Category: Radiology Authors: Wong KH, Kuciejewska A, Sharabiani MT, Ng-Cheng-Hin B, Hoy S, Hurley T, Rydon J, Grove L, Santos A, Ryugenji M, Bhide SA, Nutting CM, Harrington KJ, Newbold KL Tags: Radiother Oncol Source Type: research

Pre-irradiation tumour volumes defined by MRI and dual time-point FET-PET for the prediction of glioblastoma multiforme recurrence: A prospective study.
CONCLUSIONS: The size and geometry of GTVs differed in the majority of patients. The GTVPET volume depends on time after radionuclide injection. FET-PET better defined failure site than MRI alone. PMID: 27378734 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 1, 2016 Category: Radiology Authors: Harat M, Małkowski B, Makarewicz R Tags: Radiother Oncol Source Type: research