Radiotherapy to reinvigorate immunotherapy activity after acquired resistance in metastatic non-small-cell lung cancer: A pooled analysis of two institutions prospective phase II single arm trials

CONCLUSIONS: The current pooled analysis is a prospective evaluation of the role of radiation therapy for metastatic NSCLC in the setting of newly acquired immunotherapy resistance. Hypofractionated radiotherapy can support the outcome of immune checkpoint inhibitors and thus allow continuation of treatment for a relevant amount of time despite initial tumor progression.PMID:38070686 | DOI:10.1016/j.radonc.2023.110048

Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 9, 2023 Category: Radiology Authors: Ilinca Popp Rianne D W Vaes Lotte Wieten Sonja Adebahr Lizza Hendriks Elham Bavafaye Haghighi Juliette Degens Henning Sch äfer Christine Greil St éphanie Peeters Cornelius F Waller Ruud Houben Gabriele Niedermann Justyna Rawluk Eleni Gkika Justus Duyste Source Type: research