Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Low-dose radiotherapy synergizes with iRGD-antiCD3-modified T cells by facilitating T cell infiltration
CONCLUSION: Altogether, we demonstrated that low-dose radiotherapy could improve the antitumor potency of iRGD-antiCD3-modified T cells by promoting T cell infiltration, providing a rationale for exploring low-dose radiotherapy in combination of other adoptive T cell therapies in solid tumors.PMID:38458258 | DOI:10.1016/j.radonc.2024.110213 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 8, 2024 Category: Radiology Authors: Shujuan Zhou Mei Zhu Xiao Wei Peiyuan Mu Lijun Shen Yan Wang Juefeng Wan Hui Zhang Fan Xia Zhen Zhang Source Type: research

European association of urology risk stratification predicts outcome in patients receiving PSMA-PET-planned salvage radiotherapy for biochemical recurrence following radical prostatectomy
CONCLUSION: Our data support the EAU risk group definition. EAU risk grouping for BCR reliably predicted outcome in patients staged lymph node-negative after RP and with PSMA-PET before SRT. To our knowledge, this is the first study validating the EAU risk grouping in patients treated with PSMA-PET-planned SRT.PMID:38458259 | DOI:10.1016/j.radonc.2024.110215 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 8, 2024 Category: Radiology Authors: Sophia Scharl Constantinos Zamboglou Iosif Strouthos Andrea Farolfi Francesca Serani Stefan A Koerber J ürgen Debus Jan C Peeken Marco M E Vogel Stephanie G C Kroeze Matthias Guckenberger Manuel Krafcsik George Hruby Louise Emmett Nina-Sophie Schmidt-Heg Source Type: research

Multi-centre evaluation of variation in cumulative dose assessment in reirradiation scenarios
CONCLUSION: Large variations highlight the uncertainty in reporting cumulative doses in reirradiation scenarios, with implications for outcome analysis and understanding of published doses. Using a standardised workflow potentially including spatially mapped doses improves consistency in determination of accumulated dose in reirradiation scenarios.PMID:38453055 | DOI:10.1016/j.radonc.2024.110184 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 7, 2024 Category: Radiology Authors: Nicholas Hardcastle Eliana Vasquez Osorio Andrew Jackson Charles Mayo Anja Eineb ærholm Aarberg Myriam Ayadi Francesca Belosi Cemile Ceylan Angela Davey Pauline Dupuis Julia-Claire Handley Theresa Hemminger Lone Hoffmann Colin Kelly Chrysanthi Michailido Source Type: research

In silico evaluation and feasibility of near margin-less head and neck daily adaptive radiotherapy
CONCLUSIONS: The IOE enables feasible daily ART treatments with reduced margins while enhancing target coverage and reducing OAR doses for HNC patients. A phase II trial recently finished accrual and forthcoming analysis will determine if these dosimetric improvements correlate with improved patient-reported outcomes.PMID:38453056 | DOI:10.1016/j.radonc.2024.110178 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 7, 2024 Category: Radiology Authors: Michael Dohopolski Justin Visak Byongsu Choi Boyu Meng David Parsons Xinran Zhong Enobong Inam Vlad Avkshtol Dominic Moon David Sher Mu-Han Lin Source Type: research

Proton therapy induces a local microglial neuroimmune response
CONCLUSION: Overall, our data indicate that the brain responds in a similar manner to photons and plateau protons with a shared local upregulation of microglial priming-associated genes, potentially enhancing the immune response to subsequent inflammatory challenges.PMID:38453539 | DOI:10.1016/j.radonc.2024.110117 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 7, 2024 Category: Radiology Authors: Dani ëlle C Voshart Myrthe Klaver Yuting Jiang Hilmar R J van Weering Fleur van Buuren-Broek Gideon P van der Linden Davide Cinat Harry H Kiewiet Justin Malimban Daniel A Vazquez-Matias Luiza Reali Nazario Ayla C Scholma Jeffrey Sewdihal Marc-Jan van Goe Source Type: research

Corrigendum to "Safety and feasibility of CDK4/6 inhibitors treatment combined with radiotherapy in patients with HR-positive/HER2-negative breast cancer. A systematic review and meta-analysis" [Radiother. Oncol. 187 (2023) 109839]
Radiother Oncol. 2024 Mar 5;194:110188. doi: 10.1016/j.radonc.2024.110188. Online ahead of print.NO ABSTRACTPMID:38447357 | DOI:10.1016/j.radonc.2024.110188 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 6, 2024 Category: Radiology Authors: Marcin Kubeczko Micha ł Jarząb Dorota Gabry ś Aleksandra Krzywon Alexander J Cortez Amy J Xu Source Type: research

Dose and dose rate dependence of the tissue sparing effect at ultra-high dose rate studied for proton and electron beams using the zebrafish embryo model
CONCLUSION: The ZFE model was shown to be a suitable pre-clinical high-throughput model for radiobiological studies on FLASH radiotherapy, providing results comparable to rodent models. This underlines the relevance of ZFE studies for FLASH radiotherapy research.PMID:38447870 | DOI:10.1016/j.radonc.2024.110197 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 6, 2024 Category: Radiology Authors: Felix Horst Elisabeth Bodenstein Michael Brand Stefan Hans Leonhard Karsch Elisabeth Lessmann Steffen L öck Michael Sch ürer J örg Pawelke Elke Beyreuther Source Type: research

Targeting the CXCL12/CXCR4 pathway to reduce radiation treatment side effects
Radiother Oncol. 2024 Mar 4:110194. doi: 10.1016/j.radonc.2024.110194. Online ahead of print.ABSTRACTHigh precision, image-guided radiotherapy (RT) has increased the therapeutic ratio, enabling higher tumor and lower normal tissue doses, leading to improved patient outcomes. Nevertheless, some patients remain at risk of developing serious side effects.In many clinical situations, the radiation tolerance of normal tissues close to the target volume limits the dose that can safely be delivered and thus the potential for tumor control and cure. This is particularly so in patients being re-treated for tumor progression or a se...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 6, 2024 Category: Radiology Authors: Naz Chaudary Richard P Hill Michael Milosevic Source Type: research

Benefit of respiratory gating in the Danish Breast Cancer Group partial breast irradiation trial
CONCLUSIONS: PBI ensured a low MHD for most patients. Adding respiratory-gating further reduced MHD for upper-located but not for lower-located tumor beds but did not influence target coverage or lung doses. Respiratory-gating is no longer DBCG standard for left-sided PBI.PMID:38442840 | DOI:10.1016/j.radonc.2024.110195 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 5, 2024 Category: Radiology Authors: Kristine W H øgsbjerg Else Maae Mette H Nielsen Lars Stenbygaard Anders N Pedersen Esben Yates Martin Berg Ebbe L Lorenzen Ingelise Jensen Mirjana Josipovic Mette S Thomsen Birgitte V Offersen Source Type: research

Characterization of the signal transduction cascade for inflammatory gene expression in fibroblasts with ATM-ATR deficiencies after Ionizing radiation
CONCLUSION: Enhanced micronuclei formation upon ATM, ATR, or MRE11 deficiency activated the cGAS/STING, RIG-I-MDA-5-IRF7-IL6 pathway, resulting in its downstream interferon stimulated gene expression following exposure to IR. Our study provides comprehensive information regarding the status of inflammation-related gene expression under DSB repair deficiency after IR. The generated dataset may be useful in developing functional biomarkers to accurately identify patients sensitive to radiotherapy.PMID:38438016 | DOI:10.1016/j.radonc.2024.110198 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeu...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 4, 2024 Category: Radiology Authors: Shunji Haruna Ken Okuda Akiko Shibata Mayu Isono Kohei Tateno Hiro Sato Takahiro Oike Yuki Uchihara Yu Kato Atsushi Shibata Source Type: research

Less than whole uterus irradiation for patients with locally advanced cervical cancer
CONCLUSIONS: Including less than the whole uterus for definitive cervix cancer IMRT does not seem to compromise local control. Less than whole uterus irradiation could be considered for carefully selected cervix cancer patients to decrease bowel dose and possible treatment-related toxicity.PMID:38438017 | DOI:10.1016/j.radonc.2024.110199 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 4, 2024 Category: Radiology Authors: Caressa Hui Agnes Ewongwo Maria G Mendoza Margaret M Kozak Scott Jackson Jie Fu Elizabeth Kidd Source Type: research