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Margin reduction in radiotherapy for glioblastoma through 18F-fluoroethyltyrosine PET? - A recurrence pattern analysis.
iyazi M Abstract BACKGROUND AND PURPOSE: 18F-fluoroethyltyrosine (18F-FET) PET is increasingly used in radiation treatment planning for the primary treatment of glioblastoma (GBM) patients additionally to contrast-enhanced MRI. To answer the question, whether a margin reduction in the primary treatment setting could be achieved through 18F-FET PET imaging, a recurrence pattern analysis was performed. PATIENTS AND METHODS: GBM patients undergoing 18F-FET PET examination before primary radiochemotherapy from 05/2009 to 11/2014 were included into the recurrence pattern analysis. Biological tumour volumes were se...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 6, 2020 Category: Radiology Authors: Fleischmann DF, Unterrainer M, Schön R, Corradini S, Maihöfer C, Bartenstein P, Belka C, Albert NL, Niyazi M Tags: Radiother Oncol Source Type: research

Stereotactic body radiation therapy planning for liver tumors using functional images from dual-energy computed tomography.
This study aimed to generate a functional image of the liver using dual-energy computed tomography (DECT) and a functional-image-based stereotactic body radiation therapy plan to minimize the dose to the volume of the functional liver (Vfl). MATERIAL AND METHODS: A normalized iodine density (NID) map was generated for fifteen patients with liver tumors. The volume of liver with an NID 
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 6, 2020 Category: Radiology Authors: Ohira S, Kanayama N, Toratani M, Ueda Y, Koike Y, Karino T, Shunsuke O, Miyazaki M, Koizumi M, Teshima T Tags: Radiother Oncol Source Type: research

Comparisons between radiofrequency ablation and stereotactic body radiotherapy for liver malignancies: Meta-analyses and a systematic review.
Abstract INTRODUCTION: Radiofrequency ablation (RFA) is a standard ablative modality for small liver malignancies. Stereotactic body radiotherapy (SBRT) has emerged although yet suffers a lack of high-level evidence. We performed meta-analyses and a systematic review to integrate the literature and help in clinical decision-making. METHODS: Systemic searches were performed of the PubMed, Medline, and EMBASE databases to identify controlled studies comparing RFA and SBRT. RESULTS: Eleven studies involving 2238 patients were included. Among them, eight studies were for treating early hepatocellular carcino...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 6, 2020 Category: Radiology Authors: Lee J, Shin IS, Yoon WS, Koom WS, Rim CH Tags: Radiother Oncol Source Type: research

Late toxicity and quality of life with prostate only or whole pelvic radiation therapy in high risk prostate cancer (POP-RT): A randomised trial.
Abstract AIM: To report toxicity and quality of life (QOL) outcomes from a randomised trial of prostate only versus whole pelvic radiotherapy in high risk, node negative prostate cancer. MATERIALS/METHODS: Patients with localised prostate adenocarcinoma and nodal involvement risk > 20%, were randomised to prostate only (PORT, 68 Gy/25# to prostate) and whole pelvis (WPRT, 68 Gy/25# to prostate and 50 Gy/25# to pelvis) arms with stratification for TURP, Gleason score, baseline PSA, and type of androgen deprivation therapy (ADT). Image guided intensity modulated radiotherapy (IG-IMRT...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 6, 2020 Category: Radiology Authors: Murthy V, Maitre P, Bhatia J, Kannan S, Krishnatry R, Prakash G, Bakshi G, Pal M, Menon S, Mahantshetty U Tags: Radiother Oncol Source Type: research

Combined proton-photon treatments - A new approach to proton therapy without a gantry.
CONCLUSION: Combined proton-photon treatments may play a role in developing a new solution for proton therapy without a gantry. Optimal combinations improve on IMRT plans and reduce the risk of side effects while making protons available to more patients. PMID: 31923713 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 6, 2020 Category: Radiology Authors: Fabiano S, Balermpas P, Guckenberger M, Unkelbach J Tags: Radiother Oncol Source Type: research

Distributed learning on 20 000+ lung cancer patients - The Personal Health Train.
CONCLUSION: The PHT infrastructure demonstrably overcomes patient privacy barriers to healthcare data sharing and enables fast data analyses across multiple institutes from different countries with different regulatory regimens. This infrastructure promotes global evidence-based medicine while prioritizing patient privacy. PMID: 31911366 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 2, 2020 Category: Radiology Authors: Deist TM, Dankers FJWM, Ojha P, Scott Marshall M, Janssen T, Faivre-Finn C, Masciocchi C, Valentini V, Wang J, Chen J, Zhang Z, Spezi E, Button M, Jan Nuyttens J, Vernhout R, van Soest J, Jochems A, Monshouwer R, Bussink J, Price G, Lambin P, Dekker A Tags: Radiother Oncol Source Type: research

The role of postoperative thoracic radiotherapy and prophylactic cranial irradiation in early stage small cell lung cancer: Patient selection among ESTRO experts.
CONCLUSION: PCI and TRT are considered in patients with resected SCLC and these treatments should be discussed with the patient in the context of shared decision-making. PMID: 31887577 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 26, 2019 Category: Radiology Authors: Putora PM, De Ruysscher D, Glatzer M, Widder J, Van Houtte P, Troost EGC, Slotman BJ, Ramella S, Pöttgen C, Peeters S, Nestle U, McDonald F, Le Pechoux C, Dziadziuszko R, Belderbos J, Faivre-Finn C Tags: Radiother Oncol Source Type: research

International consensus recommendations for target volume delineation specific to sacral metastases and spinal stereotactic body radiation therapy (SBRT).
CONCLUSION: Consensus recommendations for CTV target delineation specific to sacral metastases treated with SBRT were established using expert contours. This is a critical first step to achieving standardisation of target delineation practice in the sacrum and will serve as a baseline for meaningful pattern of failure analyses going forward. PMID: 31874346 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 20, 2019 Category: Radiology Authors: Dunne EM, Sahgal A, Lo SS, Bergman A, Kosztyla R, Dea N, Chang EL, Chang UK, Chao ST, Faruqi S, Ghia AJ, Redmond KJ, Soltys SG, Liu MC Tags: Radiother Oncol Source Type: research

Partial breast irradiation with the 1.5  T MR-Linac: First patient treatment and analysis of electron return and stream effects.
CONCLUSION: PBI with the 1.5 T MR-Linac was performed for the first time. ESE is accurately calculated by the treatment planning system, can be effectively reduced with a 1 cm bolus and is comparable to dose of cone beam-CT based position verification. The additional dose caused by ERE is not associated with an increased risk of acute toxicity. PMID: 31874347 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 20, 2019 Category: Radiology Authors: Nachbar M, Mönnich D, Boeke S, Gani C, Weidner N, Heinrich V, Lo Russo M, Livi L, Winter J, Tsitsekidis S, Dohm O, Thorwarth D, Zips D, De-Colle C Tags: Radiother Oncol Source Type: research

Recommendations from gynaecological (GYN) GEC-ESTRO working group - ACROP: Target concept for image guided adaptive brachytherapy in primary vaginal cancer.
CONCLUSION: This target concept for IGABT of primary vaginal cancer defines adaptive target volumes for volumetric dose prescription and should improve comparability of different radiotherapy schedules of this rare disease. A prospective evaluation of the target volume concept within a multicentre study is planned. PMID: 31874348 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 20, 2019 Category: Radiology Authors: Schmid MP, Fokdal L, Westerveld H, Chargari C, Rohl L, Morice P, Nesvacil N, Mazeron R, Haie-Meder C, Pötter R, Nout RA, GEC-ESTRO GYN Working Group Tags: Radiother Oncol Source Type: research

Clinical evaluation of a full-image deep segmentation algorithm for the male pelvis on cone-beam CT and CT.
CONCLUSION: This study shows that modern deep neural networks are capable of producing clinically applicable organ segmentation for the male pelvis. The model is able to produce acceptable structures as frequently as current clinical routine. Therefore, deep neural networks can simplify the clinical workflow by offering initial segmentations. The study further shows that to retain the clinicians' personal preferences a structure review and correction is necessary for structures both created by other clinicians and deep neural networks. PMID: 31869676 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncolo...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 19, 2019 Category: Radiology Authors: Schreier J, Genghi A, Laaksonen H, Morgas T, Haas B Tags: Radiother Oncol Source Type: research

Development and validation of a CT-based radiomic nomogram for preoperative prediction of early recurrence in advanced gastric cancer.
Abstract BACKGROUND: In the clinical management of advanced gastric cancer (AGC), preoperative identification of early recurrence after curative resection is essential. Thus, we aimed to create a CT-based radiomic model to predict early recurrence in AGC patients preoperatively. MATERIALS AND METHODS: We enrolled 669 consecutive patients (302 in the training set, 219 in the internal test set and 148 in the external test set) with clinicopathologically confirmed AGC from two centers. Radiomic features were extracted from preoperative diagnostic CT images. Machine learning methods were applied to shrink feature...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 19, 2019 Category: Radiology Authors: Zhang W, Fang M, Dong D, Wang X, Ke X, Zhang L, Hu C, Guo L, Guan X, Zhou J, Shan X, Tian J Tags: Radiother Oncol Source Type: research

High dose radiation therapy based on normal tissue constraints with concurrent chemotherapy achieves promising survival of patients with unresectable stage III non-small cell lung cancer.
Abstract BACKGROUND AND PURPOSE: We aimed to investigate the potential of individual isotoxic dose escalation based on normal tissue constraints (NTC), hypothesizing that high dose radiation therapy would be superior to standard-dose in concurrent chemoradiotherapy for unresectable stage III non-small cell lung cancer (NSCLC). MATERIALS AND METHODS: Individually prescribed radiation doses were calculated based on NTC. Patients with total tumour radiation doses ≥66 Gy were assigned to the high dose (HD, ≥66 Gy) group, and all other patients were assigned to the standard-dose (SD,
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 19, 2019 Category: Radiology Authors: Zhao Q, Liu M, Wang Z, Huang W, Allen Li X, Zhou T, Zhang J, Zhang Z, Wang Q, Yu S, Han D, Sun H, Li H, Lin H, Li B Tags: Radiother Oncol Source Type: research

Dose response and architecture in volume staged radiosurgery for large arteriovenous malformations: A multi-institutional study.
CONCLUSION: VS-SRS is an option for upfront treatment of large AVMs. Higher dose was associated with improved rates of nCR, obliteration, and cure suggesting that larger volumetric responses may facilitate salvage therapy and optimize the chance for cure. PMID: 31835173 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 9, 2019 Category: Radiology Authors: Seymour ZA, Chan JW, Sneed PK, Kano H, Lehocky CA, Jacobs RC, Ye H, Chytka T, Liscak R, Lee CC, Yang HC, Ding D, Sheehan J, Feliciano CE, Rodriguez-Mercado R, Chiang VL, Hess JA, Sommaruga S, McShane B, Lee J, Vasas LT, Kaufmann AM, Grills I, McDermott MW Tags: Radiother Oncol Source Type: research

On the limitations of the area under the ROC curve for NTCP modelling.
Abstract The area under the ROC curve (AUC) is commonly used as a measure for the discriminative performance of NTCP models. Here, we demonstrate that for typical patient cohorts, the AUC is an unsuitable measure for that purpose since it is typically limited to values below 0.8 and it exhibits large statistical variation. PMID: 31812929 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 4, 2019 Category: Radiology Authors: Bahn E, Alber M Tags: Radiother Oncol Source Type: research

Comparing deep learning-based auto-segmentation of organs at risk and clinical target volumes to expert inter-observer variability in radiotherapy planning.
CONCLUSIONS: The accuracy of DCs trained by a single RO is comparable to expert inter-observer variability for the RT planning contours in this study. Use of deep learning-based auto-segmentation in clinical practice will likely lead to significant benefits to RT planning workflow and resources. PMID: 31812930 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 4, 2019 Category: Radiology Authors: Wong J, Fong A, McVicar N, Smith S, Giambattista J, Wells D, Kolbeck C, Giambattista J, Gondara L, Alexander A Tags: Radiother Oncol Source Type: research

Macrophage exclusion after radiation therapy (MERT): A new and effective way to increase the therapeutic ratio of radiotherapy.
Abstract Here we review a variety of preclinical studies and a first-in-human clinical trial of newly diagnosed glioblastoma (GBM) patients that have investigated the significance of the influx of tumor associated macrophages (TAMs) into tumors after irradiation. We summarize the effects on the response of the tumors and normal tissues to radiation of various agents that either reduce the influx of TAMs into tumors after radiation or change their M1/M2 polarization. The studies show that following irradiation there is an accumulation of bone marrow derived TAMs in the irradiated tumors. These TAMs stimulate the re...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 4, 2019 Category: Radiology Authors: Brown JM, Thomas R, Nagpal S, Recht L Tags: Radiother Oncol Source Type: research

Brain metastases from non-small cell lung cancer with EGFR or ALK mutations: A systematic review and meta-analysis of multidisciplinary approaches.
Abstract BACKGROUND AND PURPOSE: To analyze outcomes of non-small cell lung cancer (NSCLC) patients with brain metastases harboring EGFR or ALK mutations and examine for differences between tyrosine kinase inhibitors (TKIs) alone, radiotherapy (RT) alone (either whole brain radiation therapy (WBRT) or stereotactic radiosurgery (SRS)), or combined TKIs and RT. MATERIALS AND METHODS: Thirty studies were identified. PATIENTS: with brain metastases from NSCLC. INTERVENTION: initial TKIs alone with optional salvage RT, RT alone, or TKIs and RT. CONTROL: wild-type NSCLC and TKIs alone for mutational ...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 4, 2019 Category: Radiology Authors: Singh R, Lehrer EJ, Ko S, Peterson J, Lou Y, Porter AB, Kotecha R, Brown PD, Zaorsky NG, Trifiletti DM Tags: Radiother Oncol Source Type: research

Dosimetric predictors of toxicity and quality of life following prostate stereotactic ablative radiotherapy.
CONCLUSIONS: This report confirms that the high-dose regions in the bladder and rectum are more significant predictors of late toxicity and QOL after prostate SABR compared to low-dose regions. Caution must be taken to avoid high doses and hotspots in those organs. PMID: 31809979 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 2, 2019 Category: Radiology Authors: Alayed Y, Davidson M, Quon H, Cheung P, Chu W, Chung HT, Vesprini D, Ong A, Chowdhury A, Liu SK, Panjwani D, Helou J, Musunuru HB, Pang G, Korol R, Ravi A, McCurdy B, Zhang L, Mamedov A, Deabreu A, Commisso A, Commisso K, D'Alimonte L, Ho L, Bhounr Z, Lob Tags: Radiother Oncol Source Type: research

Long-term follow-up experience in anal canal cancer treated with Intensity-Modulated Radiation Therapy: Clinical outcomes, patterns of relapse and predictors of failure.
CONCLUSION: CRT with IMRT assures excellent local control in locally advanced SCCAC with manageable long-term toxicity. Multicentric prospective trials are required to reinforce those results. PMID: 31809980 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 2, 2019 Category: Radiology Authors: de Meric de Bellefon M, Lemanski C, Castan F, Samalin E, Mazard T, Lenglet A, Demontoy S, Riou O, Llacer-Moscardo C, Fenoglietto P, Aillères N, Thezenas S, Debrigode C, Vieillot S, Gourgou S, Azria D Tags: Radiother Oncol Source Type: research

Radiotherapy in the treatment of extracranial hemangiopericytoma/solitary fibrous tumor: Study from the Rare Cancer Network.
Abstract BACKGROUND AND PURPOSE: The role of radiotherapy (RT) in the treatment of hemangiopericytoma/solitary fibrous tumor (HPC/SFT) is still under debate. We aimed at investigating whether radiotherapy can improve the results in patients operated for extracranial HPC/SFT. MATERIALS AND METHODS: Data from patients with HPC/SFT, treated from 1982 to 2012, were retrospectively reviewed within the Rare Cancer Network framework. Actuarial local control (LC), disease-free survival (DFS), metastasis-free survival (MFS) and overall survival (OS) were calculated with Kaplan-Meyer method. Patient and tumor parameter...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 1, 2019 Category: Radiology Authors: Krengli M, Cena T, Zilli T, Jereczek-Fossa BA, De Bari B, Villa Freixa S, Kaanders JHAM, Torrente S, Pasquier D, Sole CV, Lutsyk M, Dincbas FO, Habboush Y, Fariselli L, Dragan T, Baumert BG, Khanfir K, Ugurluer G, Thariat J Tags: Radiother Oncol Source Type: research

Diffusion MRI outlined viable tumour volume beats GTV in intra-treatment stratification of outcome.
CONCLUSION: GTV size change during radiotherapy is not a reliable predictor of outcome in brain metastases. On the other hand, change in the volume fraction of VTV and diffusivity of VTV shows ability to stratify treatment outcome. PMID: 31805516 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 1, 2019 Category: Radiology Authors: Mahmood F, Hjorth Johannesen H, Geertsen P, Hansen RH Tags: Radiother Oncol Source Type: research

Modelling the risk of radiation induced alopecia in brain tumor patients treated with scanned proton beams.
CONCLUSION: We derived NTCP models to predict G2-RIA after PT, providing a comprehensive modelling framework for acute, late and permanent occurrences that, once externally validated, could be exploited for individualized scalp sparing treatment planning strategies in brain tumor patients. PMID: 31805517 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 1, 2019 Category: Radiology Authors: Palma G, Taffelli A, Fellin F, D'Avino V, Scartoni D, Tommasino F, Scifoni E, Durante M, Amichetti M, Schwarz M, Amelio D, Cella L Tags: Radiother Oncol Source Type: research

A framework for modeling radiation induced lymphopenia in radiotherapy.
CONCLUSION: We have presented a framework of developing an immune OAR model that has the potential to predict and minimize RIL in radiotherapy. PMID: 31794944 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 29, 2019 Category: Radiology Authors: Jin JY, Mereniuk T, Yalamanchali A, Wang W, Machtay M, Spring Kong FM, Ellsworth S Tags: Radiother Oncol Source Type: research

Fully automated detection of heart irradiation in cine MV images acquired during breast cancer radiotherapy.
CONCLUSIONS: Automated heart edge detection in cine MV images was proposed, developed and shown to be highly efficient for heart exposure detection in tangential breast fields. It may allow unsupervised surveillance of heart exposure at all tangential breast cancer treatments in a clinic. PMID: 31787350 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 27, 2019 Category: Radiology Authors: Poulsen PR, Thomsen MS, Hansen R, Worm E, Spejlborg H, Offersen B Tags: Radiother Oncol Source Type: research

Utilization and factors precluding the initiation of consolidative durvalumab in unresectable stage III non-small cell lung cancer.
Abstract Durvalumab after concurrent chemoradiation has significantly improved survival in stage III non-small cell lung cancer (NSCLC). However, there is limited data evaluating the utilization and challenges to deliver durvalumab consolidation in the real world. We assessed the use of consolidative durvalumab at a large academic center to examine clinical limitations to delivery of this practice-changing regimen. We found that despite incorporating consolidative durvalumab into standard practice for stage III unresectable NSCLC, 27% patients did not initiate this treatment, largely due to disease progression or ...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 27, 2019 Category: Radiology Authors: Shaverdian N, Offin MD, Rimner A, Shepherd AF, Wu AJ, Rudin CM, Hellmann MD, Chaft JE, Gomez DR Tags: Radiother Oncol Source Type: research

Systematic review of educational interventions to improve contouring in radiotherapy.
CONCLUSION: The literature on educational interventions designed to improve contouring performance is limited and heterogenous. Onsite, online and blended learning courses have all been shown to be helpful, however, sample sizes are small and impact assessment is almost exclusively short-term and typically does not take into account the effect on treatment planning. The most effective teaching methodology/format is unknown and impact on daily clinical practice is uncertain. PMID: 31786422 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 27, 2019 Category: Radiology Authors: Cacicedo J, Navarro-Martin A, Gonzalez-Larragan S, De Bari B, Salem A, Dahele M Tags: Radiother Oncol Source Type: research

Simulated multileaf collimator tracking for stereotactic liver radiotherapy guided by kilovoltage intrafraction monitoring: Dosimetric gain and target overdose trends.
CONCLUSIONS: Intrafraction tumor motion can deteriorate the CTV dose of liver SBRT. The planned CTV dose coverage may be restored with KIM-guided MLC tracking. However, MLC tracking may have a tendency to create hotspots in the CTV. PMID: 31786423 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 27, 2019 Category: Radiology Authors: Poulsen PR, Murtaza G, Worm ES, Ravkilde T, O'Brien R, Grau C, Høyer M, Keall P Tags: Radiother Oncol Source Type: research

Response to Comment on - Long-term risks of secondary cancers for various whole and partial breast irradiation techniques.
PMID: 31785829 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 26, 2019 Category: Radiology Authors: Pignol JP, Hoekstra N Tags: Radiother Oncol Source Type: research

Synchronous versus sequential chemo-radiotherapy in patients with early stage breast cancer (SECRAB): A randomised, phase III, trial.
Abstract BACKGROUND: The optimal sequence of adjuvant chemotherapy and radiotherapy for breast cancer is unknown. SECRAB assesses whether local control can be improved without increased toxicity. METHODS: SECRAB was a prospective, open-label, multi-centre, phase III trial comparing synchronous to sequential chemo-radiotherapy, conducted in 48 UK centres. Patients with invasive, early stage breast cancer were eligible. Randomisation (performed using random permuted block assignment) was stratified by centre, axillary surgery, chemotherapy, and radiotherapy boost. Permitted chemotherapy regimens included CMF an...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 26, 2019 Category: Radiology Authors: Fernando IN, Bowden SJ, Herring K, Brookes CL, Ahmed I, Marshall A, Grieve R, Churn M, Spooner D, Latief TN, Agrawal RK, Brunt AM, Stevens A, Goodman A, Canney P, Bishop J, Ritchie D, Dunn J, Poole CJ, Rea DW, SECRAB Investigators Tags: Radiother Oncol Source Type: research

Dose-volume predictors of early esophageal toxicity in non-small cell lung cancer patients treated with accelerated-hyperfractionated radiotherapy.
CONCLUSION: Our results show a more dominant dose-volume effect in the CHARTWEL arm compared to conventional fractionation, especially for higher esophageal doses. These findings support the notion that dose-volume parameters for radiation esophagitis determined in a specific and time dependent setting of field arrangements can not be easily transferred to another setting. In clinical practice esophageal volumes receiving 40 Gy or more should be strictly limited in hyperfractionated-accelerated fraction schemes. PMID: 31767470 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 21, 2019 Category: Radiology Authors: Bütof R, Löck S, Soliman M, Haase R, Perrin R, Richter C, Appold S, Krause M, Baumann M Tags: Radiother Oncol Source Type: research

Tumor mutation burden, immune checkpoint crosstalk and radiosensitivity in single-cell RNA sequencing data of breast cancer.
CONCLUSIONS: RR cells exhibited a basal subtype, high PD-L1 expression, and high TMB with mutational signature found in tumors having MSI. Differential crosstalk between tumor and immune cells was associated with the patient subtype of breast cancer. These findings could be useful to identify potential biomarker(s) and optimal combination strategies of immune checkpoint blockades and radiation therapy in the management of breast cancer. PMID: 31767471 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 21, 2019 Category: Radiology Authors: Jang BS, Han W, Kim IA Tags: Radiother Oncol Source Type: research

Variation in current prescription practice of stereotactic body radiotherapy for peripherally located early stage non-small cell lung cancer: Recommendations for prescribing and recording according to the ACROP guideline and ICRU report 91.
ans C Abstract BACKGROUND AND PURPOSE: In 2017 the ACROP guideline on SBRT for peripherally located early stage NSCLC was published. Later that year ICRU-91 about prescribing, recording and reporting was published. The purpose of this study is to quantify the current variation in prescription practice in the institutions that contributed to the ACROP guideline and to establish the link between the ACROP and ICRU-91 recommendations. MATERIAL AND METHODS: From each of the eight participating centres, 15 SBRT plans for stage I NSCLC were analyzed. Plans were generated following the institutional protocol, centre...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 21, 2019 Category: Radiology Authors: de Jong EEC, Guckenberger M, Andratschke N, Dieckmann K, Hoogeman MS, Milder M, Møller DS, Nyeng TB, Tanadini-Lang S, Lartigau E, Lacornerie T, Senan S, Verbakel W, Verellen D, De Kerf G, Hurkmans C Tags: Radiother Oncol Source Type: research

A randomised assessment of image guided radiotherapy within a phase 3 trial of conventional or hypofractionated high dose intensity modulated radiotherapy for prostate cancer.
We present a pre-planned analysis of the impact of IGRT on dosimetry and acute/late pelvic side effects using gastrointestinal and genitourinary clinician and patient-reported outcomes (PRO) and evaluate efficacy. MATERIALS AND METHODS: CHHiP is a randomised phase 3, non-inferiority trial for men with localised prostate cancer. 3216 patients were randomly assigned to conventional (74 Gy in 2 Gy/fraction (f) daily) or moderate hypofractionation (60 or 57 Gy in 3 Gy/f daily) between October 2002 and June 2011. The IGRT substudy included a second randomisation assigning to no-IGRT, IGRT-S (standard CTV-PTV margin...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 21, 2019 Category: Radiology Authors: Murray J, Griffin C, Gulliford S, Syndikus I, Staffurth J, Panades M, Scrase C, Parker C, Khoo V, Dean J, Mayles H, Mayles P, Thomas S, Naismith O, Baker A, Mossop H, Cruickshank C, Hall E, Dearnaley D, CHHiP Investigators Tags: Radiother Oncol Source Type: research

Local and regional treatment response by 18FDG-PET-CT-scans 4  weeks after concurrent hypofractionated chemoradiotherapy in locally advanced NSCLC.
CONCLUSION: Early post-treatment PET-metrics are associated with treatment outcome in LA-NSCLC patients treated with chemoradiotherapy. Both volumetric and intensity PET-metrics are useful, but more for the primary tumor than for lymph nodes. PMID: 31767474 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 21, 2019 Category: Radiology Authors: van Diessen JNA, La Fontaine M, van den Heuvel MM, van Werkhoven E, Walraven I, Vogel WV, Belderbos JSA, Sonke JJ Tags: Radiother Oncol Source Type: research

The impact of baseline shifts towards the heart after image guidance on survival in lung SABR patients.
CONCLUSIONS: Baseline shifts towards the heart significantly correlate with overall survival in a cohort of NSCLC SABR patients, with increased risk with increasing shifts towards the heart. These results provide further evidence for the use of stricter heart dose planning constraints for thoracic radiotherapy and suggest a heart planning organ at risk volume may be required for SABR treatments to account for baseline shifts. PMID: 31740185 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 14, 2019 Category: Radiology Authors: Johnson-Hart C, Price G, Vasquez Osorio E, Faivre-Finn C, van Herk M Tags: Radiother Oncol Source Type: research

MRI-based IMPT planning for prostate cancer.
CONCLUSIONS: This work demonstrate the clinical acceptability of substituting MR converted RSP images instead of CT for IMPT planning of prostate cancer. This further translates into higher contouring accuracy along with lesser imaging dose. PMID: 31734604 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 13, 2019 Category: Radiology Authors: Depauw N, Keyriläinen J, Suilamo S, Warner L, Bzdusek K, Olsen C, Kooy H Tags: Radiother Oncol Source Type: research

Assessment of risk factors associated with development of oronasal fistula as a late complication after carbon-ion radiotherapy for head and neck cancer.
CONCLUSION: The number of teeth irradiated with more than 50 Gy (RBE) is a significant independent risk factor for the development of ONF, which is a late complication of C-ion RT delivered in 16 fractions. PMID: 31733488 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 12, 2019 Category: Radiology Authors: Bhattacharyya T, Koto M, Ikawa H, Hayashi K, Hagiwara Y, Tsuji H Tags: Radiother Oncol Source Type: research

Axial cortical involvement of metastatic lesions to identify impending femoral fractures; a clinical validation study.
This study aims to validate the clinical reliability of axial cortical involvement with a 30 mm threshold on conventional radiographs to assess fracture risk in femoral bone metastases. MATERIALS AND METHODS: All patients with bone metastases who received radiotherapy for pain included in two multicentre prospective studies were selected. Conventional radiographs obtained at a maximum of two months prior to radiotherapy were collected. Three experts independently measured lesions and scored radiographic characteristics. Sensitivity, specificity, positive (PPV) and negative predictive value (NPV) were calculated. ...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 12, 2019 Category: Radiology Authors: van der Wal CWPG, Eggermont FE, Fiocco M, Kroon HM, Ayu O, Slot A, Snyers A, Rozema T, Verdonschot NJJ, Dijkstra PDS, Tanck EJ, van der Linden YM Tags: Radiother Oncol Source Type: research

Health-related quality of life after prophylactic cranial irradiation for stage III non-small cell lung cancer patients: Results from the NVALT-11/DLCRG-02 phase III study.
CONCLUSION: No statistically significant nor a clinically relevant impact of PCI on HRQoL was observed. PMID: 31733490 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 12, 2019 Category: Radiology Authors: Witlox WJA, Ramaekers BLT, Joore MA, Dingemans AC, Praag J, Belderbos J, Tissing-Tan C, Herder G, Haitjema T, Ubbels JF, Lagerwaard J, El Sharouni SY, Stigt JA, Smit EF, van Tinteren H, van der Noort V, Groen HJM, De Ruysscher DKM Tags: Radiother Oncol Source Type: research

Heterogeneity in tumours: Validating the use of radiomic features on 18F-FDG PET/CT scans of lung cancer patients as a prognostic tool.
CONCLUSION: The pre-selected RFs were insignificant in predicting PFS in combination with GTV, clinical stage and histology. These results might be due to variations in technical parameters. However, it is relevant to question whether RFs are stable enough to provide clinically useful information. PMID: 31733491 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 12, 2019 Category: Radiology Authors: Krarup MMK, Nygård L, Vogelius IR, Andersen FL, Cook G, Goh V, Fischer BM Tags: Radiother Oncol Source Type: research

The risk of distant metastases in rectal cancer managed by a watch-and-wait strategy - A systematic review and meta-analysis.
CONCLUSIONS: The additional risk of DM seems to be low. However, the high probability of bias, heterogeneity of the patients' population and low quality of evidence make our estimation uncertain. PMID: 31710938 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 7, 2019 Category: Radiology Authors: Socha J, Kępka L, Michalski W, Paciorek K, Bujko K Tags: Radiother Oncol Source Type: research

Prognostic importance of radiologic extranodal extension in HPV-positive oropharyngeal carcinoma and its potential role in refining TNM-8 cN-classification.
This study examines outcome heterogeneity and potential to refine the TNM-8 cN-classification using radiologic extranodal extension (rENE) in a contemporary HPV-positive (HPV+) oropharyngeal carcinoma (OPC) cohort. METHODS: All HPV+ OPC treated with definitive IMRT from 2010-2015 were included. Pre-treatment CT/MR of cN+ cases were reviewed by a head-neck radiologist for rENE. Overall survival (OS) and disease-free survival (DFS) were compared between rENE-positive (rENE+) vs rENE-negative (rENE-). Multivariable analysis (MVA) for OS confirmed the prognostic value of rENE. Refined cN-classifications for new TNM stagin...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 7, 2019 Category: Radiology Authors: Huang SH, O'Sullivan B, Su J, Bartlett E, Kim J, Waldron JN, Ringash J, de Almeida JR, Bratman S, Hansen A, Bayley A, Cho J, Giuliani M, Hope A, Hosni A, Spreafico A, Siu L, Chepeha D, Tong L, Xu W, Yu E Tags: Radiother Oncol Source Type: research

Prognostic factors for local control and survival for inoperable pulmonary colorectal oligometastases treated with stereotactic body radiotherapy.
Abstract PURPOSE: The study aimed to evaluate overall survival and local control, and to identify factors independently associated with overall survival (OS) and local control (LC). MATERIALS AND METHODS: This retrospective study examined 118 patients with primary colorectal cancer, in whom 202 inoperable pulmonary oligometastases were treated with stereotactic body radiotherapy between 2005 and 2015. Primary endpoint was to evaluate OS and identify prognostic factors associated with OS. Secondary aim was to evaluate LC and identify prognostic factors associated with LC. RESULTS: Median follow-up was 31...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 7, 2019 Category: Radiology Authors: Sharma A, Baker S, Duijm M, Oomen-de Hoop E, Cornelissen R, Verhoef C, Hoogeman M, Jan Nuyttens J Tags: Radiother Oncol Source Type: research

RBE-weighted dose conversions for carbon ionradiotherapy between microdosimetric kinetic model and local effect model for the targets and organs at risk in prostate carcinoma.
This study was performed in the experimental treatment planning system (eTPS, V8A, Raystation, Sweden), which incorporates both MKM and LEM. CIRT plans from 10 PCA patients were collected. There were 5 steps to establish the curves: (1) design MKM plans in eTPS; (2) recalculate the physical doses from MKM to LEM and create a LEM plan in eTPS; (3) plot the RBE-weighted MKM to LEM conversion curves; (4) convert the MKM rectum constraint dose volume histogram (DVH) from NIRS to a LEM DVH; and (5) compare patients' rectum DVHs and follow-up with the converted constraint DVH. RESULTS: The conversion factors for MKM doses o...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 7, 2019 Category: Radiology Authors: Wang W, Huang Z, Sheng Y, Zhao J, Shahnazi K, Zhang Q, Jiang G Tags: Radiother Oncol Source Type: research

Microscopic intramural extension of rectal cancer after neoadjuvant chemoradiation: A meta-analysis based on individual patient data.
Abstract OBJECTIVE: In selected rectal cancer patients with residual local disease following neoadjuvant chemoradiation (CRT) and the preference of an organ preservation pathway, additional treatment with dose escalation by endoluminal radiotherapy (RT) may ultimately result in a clinical complete response. To date, the widespread introduction of selective endoluminal radiation techniques is hampered by a lack of evidence-based guidelines that describe the radiation treatment volume in relation to the residual tumor mass. In order to convert an incomplete response into a complete one with additional treatment such...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 7, 2019 Category: Radiology Authors: Verrijssen AS, Guillem J, Perez R, Bujko K, Guedj N, Habr-Gama A, Houben R, Goudkade D, Melenhorst J, Buijsen J, Vanneste B, Grabsch HI, Bellezzo M, Paiva Fonseca G, Verhaegen F, Berbee M, Van Limbergen EJ Tags: Radiother Oncol Source Type: research

Stereotactic MR-guided adaptive radiation therapy for peripheral lung tumors.
CONCLUSION: Delivery of gated breath-hold SABR using MR-guidance resulted in significantly smaller target volumes than would have been the case with an ITV-based approach. Although on-table adaptation ensured delivery of ablative doses in all fractions, the dosimetric benefits were modest, suggesting that daily online plan adaptation may not benefit most patients with peripheral lung tumors. PMID: 31710943 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 7, 2019 Category: Radiology Authors: Finazzi T, Palacios MA, Haasbeek CJA, Admiraal MA, Spoelstra FOB, Bruynzeel AME, Slotman BJ, Lagerwaard FJ, Senan S Tags: Radiother Oncol Source Type: research

A prospective, multi-centre trial of multi-parametric MRI as a biomarker in anal carcinoma.
CONCLUSION: Several ADC parameters at various time points correlate with recurrence suggesting DW-MRI is a potential biomarker for SCCAC. PMID: 31710944 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 7, 2019 Category: Radiology Authors: Jones M, Hruby G, Coolens C, Driscoll B, Stanwell P, Kumar M, Capp A, Sridharan S, Arm J, Gallagher S, Holder C, Oldmeadow C, Martin J Tags: Radiother Oncol Source Type: research

Radiomic signature: A novel magnetic resonance imaging-based prognostic biomarker in patients with skull base chordoma.
CONCLUSIONS: The radiomics is a low-cost, non-invasive method to predict SBC prognosis preoperatively. Radiomic signature is a potential prognostic biomarker that may allow the individualized evaluation of patients with SBC. PMID: 31668985 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 24, 2019 Category: Radiology Authors: Wei W, Wang K, Liu Z, Tian K, Wang L, Du J, Ma J, Wang S, Li L, Zhao R, Cui L, Wu Z, Tian J Tags: Radiother Oncol Source Type: research

Intrapulmonary percussive ventilation leading to 20-minutes breath-hold potentially useful for radiation treatments.
Abstract We developed a training protocol based on Intrapulmonary Percussive Ventilation in order to prolong breath-hold while nearly suppressing the thorax motion. This protocol allowed ten subjects to achieve a 20-minutes-breath-hold, while reducing the residual surface motion to 1 mm around its mean position for more than 95% of the breath-hold duration. PMID: 31668897 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 23, 2019 Category: Radiology Authors: Audag N, Van Ooteghem G, Liistro G, Salini A, Geets X, Reychler G Tags: Radiother Oncol Source Type: research