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Randomized trial comparing two methods of re-irradiation after salvage surgery in head and neck squamous cell carcinoma: Once daily split-course radiotherapy with concomitant chemotherapy or twice daily radiotherapy with cetuximab.
The objective of this randomized trial was to compare two methods of re-irradiation in terms of toxicity and survival. PATIENTS AND METHODS: Patients with recurrence/second primary in previously irradiated area were randomly allocated to receive either 60 Gy over 11 weeks with concomitant 5FU - hydroxyurea (VP-arm), or 60 Gy (1.2 Gy twice daily) over 5 weeks with cetuximab (HFR-arm). Primary endpoint was treatment interruption>15 days (acute toxicity). RESULTS: Twenty-six patients were included in VP-arm and 27 in HFR-arm. One patient in VP-arm experienced>15 days interruption due to toxicity,...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 18, 2018 Category: Radiology Authors: Tao Y, Faivre L, Laprie A, Boisselier P, Ferron C, Jung GM, Racadot S, Gery B, Even C, Breuskin I, Bourhis J, Janot F Tags: Radiother Oncol Source Type: research

Regulation of the oxidative balance with coenzyme Q10 sensitizes human glioblastoma cells to radiation and temozolomide.
CONCLUSIONS: CoQ acts as sensitizer for cytotoxic therapies, disarming GBM cells, but not normal astrocytes, against further pro-oxidant injuries, being potentially useful in clinical practice for this fatal pathology. PMID: 29784452 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 18, 2018 Category: Radiology Authors: Frontiñán-Rubio J, Santiago-Mora RM, Nieva-Velasco CM, Ferrín G, Martínez-González A, Gómez MV, Moreno M, Ariza J, Lozano E, Arjona-Gutiérrez J, Gil-Agudo A, De la Mata M, Pesic M, Peinado JR, Villalba JM, Pérez-Romasanta L, Pérez-García VM, Alc Tags: Radiother Oncol Source Type: research

Tracking tumor biology with radiomics: A systematic review utilizing a radiomics quality score.
In this study, we performed a systematic literature search linking radiomics to tumor biology. All but two studies (n = 39) revealed that radiomic features derived from ultrasound, CT, PET and/or MR are significantly associated with one or several specific tumor biologic substrates, from somatic mutation status to tumor histopathologic grading and metabolism. Considerable inter-observer differences were found with regard to RQS scoring, while important questions were raised concerning the interpretability of the outcome of such scores. PMID: 29779918 [PubMed - as supplied by publisher] (Source: Radiotherapy and On...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 18, 2018 Category: Radiology Authors: Sanduleanu S, Woodruff HC, de Jong EEC, van Timmeren JE, Jochems A, Dubois L, Lambin P Tags: Radiother Oncol Source Type: research

Radiation dose constraints for organs at risk in neuro-oncology; the European Particle Therapy Network consensus.
CONCLUSION: The use of the European Particle Therapy Network-consensus OAR dose constraints summarized in this article is recommended for the model-based approach comparing photon and proton beam irradiation as well as for prospective clinical trials including novel radiation techniques and/or modalities. PMID: 29779919 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 17, 2018 Category: Radiology Authors: Lambrecht M, Eekers DBP, Alapetite C, Burnet NG, Calugaru V, Coremans IEM, Fossati P, Høyer M, Langendijk JA, Romero AM, Paulsen F, Perpar A, Renard L, de Ruysscher D, Timmermann B, Vitek P, Weber DC, van der Weide HL, Whitfield GA, Wiggenraad R, Roelofs Tags: Radiother Oncol Source Type: research

Preoperative radiotherapy or chemoradiotherapy in rectal cancer - Is survival improved? An update of the "Nordic" LARC study in non-resectable cancers.
Preoperative radiotherapy or chemoradiotherapy in rectal cancer - Is survival improved? An update of the "Nordic" LARC study in non-resectable cancers. Radiother Oncol. 2018 May 16;: Authors: Brændengen M, Glimelius B Abstract The randomized "Nordic" LARC study compared preoperative long-course radiotherapy alone (RT) or with chemotherapy (CRT) in the most locally advanced/ugly rectal cancers. Despite significantly better local control in the CRT group, no overall survival benefit was seen after 10 years follow-up. The relations between local control and survival are discus...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 16, 2018 Category: Radiology Authors: Brændengen M, Glimelius B Tags: Radiother Oncol Source Type: research

Risk factors for near-miss events and safety incidents in pediatric radiation therapy.
CONCLUSIONS: Variances in children occurred in early treatment phases, but were detected at later workflow stages. Quality measures should be implemented during early treatment phases with a focus on younger children and those cared for by cross-covering physicians. PMID: 29776675 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 15, 2018 Category: Radiology Authors: Baig N, Wang J, Elnahal S, McNutt T, Wright J, DeWeese T, Terezakis S Tags: Radiother Oncol Source Type: research

Treatment-related toxicity in men who received Intensity-modulated versus 3D-conformal radiotherapy after radical prostatectomy: A national population-based study.
CONCLUSIONS: The use of post-prostatectomy IMRT compared to 3D-CRT is not associated with a statistically significant reduction in rates of severe GU and GI toxicity, although there is some evidence that GU toxicity is lower with IMRT. We would caution against rapid transition to post-prostatectomy IMRT until further evidence is available supporting its superiority. PMID: 29773442 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 14, 2018 Category: Radiology Authors: Sujenthiran A, Nossiter J, Parry M, Charman SC, Cathcart PJ, van der Meulen J, Clarke NW, Payne H, Aggarwal A Tags: Radiother Oncol Source Type: research

Combined high dose rate brachytherapy and external beam radiotherapy for clinically localised prostate cancer.
CONCLUSION: HDR-BRT with supplemental EBRT results in low biochemical relapse-free survival rates associated with a very low incidence of higher-grade late adverse events. PMID: 29764692 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 12, 2018 Category: Radiology Authors: Strouthos I, Chatzikonstantinou G, Zamboglou N, Milickovic N, Papaioannou S, Bon D, Zamboglou C, Rödel C, Baltas D, Tselis N Tags: Radiother Oncol Source Type: research

SBRT for pancreatic cancer: In regard of Bohoudi et al.
PMID: 29759683 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 11, 2018 Category: Radiology Authors: Bohoudi O, Bruynzeel AM, Senan S, Cuijpers JP, Slotman BJ, Lagerwaard FJ, Palacios MA Tags: Radiother Oncol Source Type: research

Overall survival after stereotactic radiotherapy or surgical metastasectomy in oligometastatic renal cell carcinoma patients treated at two Swedish centres 2005-2014.
CONCLUSIONS: OS after SRT was comparable to SM and longer than expected considering patients with adverse risk profiles were common. Fit patients with non-brain metastases treated after an initial period of watchful waiting had the best prognosis. PMID: 29754859 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 10, 2018 Category: Radiology Authors: Stenman M, Sinclair G, Paavola P, Wersäll P, Harmenberg U, Lindskog M Tags: Radiother Oncol Source Type: research

Respiratory motion-resolved, self-gated 4D-MRI using Rotating Cartesian K-space (ROCK): Initial clinical experience on an MRI-guided radiotherapy system.
CONCLUSION: Our study demonstrated the clinical feasibility of using the ROCK-4D-MRI to acquire high quality, respiratory motion-resolved 4D-MRI in a low-field MRgRT system. The 4D-MRI image could provide accurate dynamic information for radiotherapy treatment planning. PMID: 29753549 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 9, 2018 Category: Radiology Authors: Han F, Zhou Z, Du D, Gao Y, Rashid S, Cao M, Shaverdian N, Hegde JV, Steinberg M, Lee P, Raldow A, Low DA, Sheng K, Yang Y, Hu P Tags: Radiother Oncol Source Type: research

Rescue procedure for an electrical storm using robotic non-invasive cardiac radio-ablation.
We report here an intensive care patient suffering from an electrical storm due to incessant VT, unresponsive to catheter ablation and anti-arrhythmic drugs, showing an immediate and durable response to electrophysiology-guided cardiac SBRT. PMID: 29753550 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 9, 2018 Category: Radiology Authors: Jumeau R, Ozsahin M, Schwitter J, Vallet V, Duclos F, Zeverino M, Moeckli R, Pruvot E, Bourhis J Tags: Radiother Oncol Source Type: research

Development of quality indicators to monitor radiotherapy care for men with prostate cancer: A modified Delphi method.
CONCLUSION: This study developed a core set of 17 QIs which will be used to report from the Prostate Cancer Outcomes Registry-Australia & New Zealand, to monitor the quality of radiotherapy care prostate cancer patients receive. PMID: 29753551 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 9, 2018 Category: Radiology Authors: Tsiamis E, Millar J, Baxi S, Borg M, De Ieso P, Elsaleh H, Foroudi F, Higgs B, Holt T, Martin J, Moretti K, Pryor D, Skala M, Evans S Tags: Radiother Oncol Source Type: research

Early ultrasonographic tumor regression after linear accelerator stereotactic fractionated photon radiotherapy of choroidal melanoma as a predictor for metastatic spread.
i R Abstract BACKGROUND AND PURPOSE: During extended follow-up (of up to 15 years), approximately fifty percent of patients with choroidal melanoma will develop metastatic disease and eventually die. Thus, continuing research on prognostic factors, early detection and treatment is necessary. Height regression rates both after plaque brachytherapy and proton beam irradiation have been shown to have prognostic value. The purpose of this study was to analyze the influence of early tumor regression rate after treatment of choroidal melanoma with LINAC stereotactic fractionated radiotherapy (SFRT) as an independent r...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 8, 2018 Category: Radiology Authors: Mitsch C, Zehetmayer M, Gleiss A, Georg D, Dieckmann K, Pötter R, Sayegh R, Schmidt-Erfurth U, Dunavoelgyi R Tags: Radiother Oncol Source Type: research

Is prophylactic cranial irradiation (PCI) needed in patients with extensive-stage small cell lung cancer showing complete response to first-line chemotherapy?
Abstract Throughout the entire world, prophylactic cranial irradiation (PCI) is the standard care for patients with small cell lung cancer (SCLC) in whom a favorable therapeutic effect is achieved after front-line treatment, regardless of whether the disease is in the limited stage or extensive stage. In the EORTC study, PCI was shown to confer a survival benefit for patients with extensive-stage small cell lung cancer (ES-SCLC) who experienced any positive response after initial chemotherapy. However, the Japan study failed to confirm a survival benefit. As a result, the guidelines in Japan recommend that PCI sho...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 7, 2018 Category: Radiology Authors: Nosaki K, Seto T, Shimokawa M, Takahashi T, Yamamoto N Tags: Radiother Oncol Source Type: research

Assessment of image quality of a radiotherapy-specific hardware solution for PET/MRI in head and neck cancer patients.
CONCLUSIONS: Simultaneous PET/MRI in HNC patients using radiotherapy positioning aids is clinically feasible. Though SNR was reduced, the image quality obtained with a radiotherapy setup meets RTP requirements and the data can thus be used for personalized RTP. PMID: 29747873 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 7, 2018 Category: Radiology Authors: Winter RM, Leibfarth S, Schmidt H, Zwirner K, Mönnich D, Welz S, Schwenzer NF, la Fougère C, Nikolaou K, Gatidis S, Zips D, Thorwarth D Tags: Radiother Oncol Source Type: research

Is prophylactic cranial irradiation indicated for patients with extensive-stage small cell lung cancer with a complete response to first-line treatment?
Abstract Prophylactic cranial irradiation (PCI) has been considered standard of care for patients with limited-stage small-cell lung cancer who achieve complete response to definitive treatment after a meta-analysis revealed its favorable effects on survival. In a European trial, PCI was also shown to confer a survival advantage for patients with extensive-stage (ES) SCLC who experienced any positive response after initial chemotherapy, leading to PCI also being considered a standard treatment for these patients as well. However, a recent Japanese trial investigating PCI for patients with ES-SCLC was stopped early...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 7, 2018 Category: Radiology Authors: Suzuki R, Komaki R Tags: Radiother Oncol Source Type: research

Radiotherapy is essential after complete response to asparaginase-containing chemotherapy in early-stage extranodal nasal-type NK/T-cell lymphoma: A multicenter study from the China Lymphoma Collaborative Group (CLCG).
This study aimed to clarify the benefit of radiotherapy (RT) in patients with early-stage extranodal NK/T-cell lymphoma (NKTCL) who achieve a complete response (CR) after asparaginase-containing chemotherapy (CT). PATIENTS AND METHODS: Of 240 patients achieved a CR after asparaginase-containing CT, 202 patients received additional RT (CT + RT), and 38 patients did not (CT alone). RESULTS: Compared to CT alone, CT + RT significantly improved overall survival (OS), disease-free survival (DFS) and locoregional control (LRC). The 5-year OS, DFS and LRC rates were 84.9%, 76.2% and 84.9% for CT + RT, compar...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 5, 2018 Category: Radiology Authors: Deng XW, Wu JX, Wu T, Zhu SY, Shi M, Su H, Wang Y, He X, Xu LM, Yuan ZY, Zhang LL, Wu G, Qu BL, Qian LT, Hou XR, Zhang FQ, Zhang YJ, Zhu Y, Cao JZ, Lan SM, Dong M, Qi SN, Yang Y, Li YX Tags: Radiother Oncol Source Type: research

Volumetric modulated arc therapy of head-and-neck cancer on a fast-rotating O-ring linac: Plan quality and delivery time comparison with a C-arm linac.
CONCLUSION: For VMAT of HNC, the fast-rotating O-ring linac at least maintains the plan quality of two arcs on a C-arm linac while reducing the image acquisition and plan delivery time. PMID: 29739713 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 5, 2018 Category: Radiology Authors: Michiels S, Poels K, Crijns W, Delombaerde L, De Roover R, Vanstraelen B, Haustermans K, Nuyts S, Depuydt T Tags: Radiother Oncol Source Type: research

Comparison of survival and prognostic factors in patients treated with stereotactic body radiotherapy for oligometastases or oligoprogression.
CONCLUSION: Survival and distant relapse following SBRT to OM/OP is determined by the extent of metastatic disease and performance status. Future research should address the benefit of integrating SBRT with systemic therapies to allow deferral or continuation of therapeutic agents. PMID: 29735409 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 4, 2018 Category: Radiology Authors: Pembroke CA, Fortin B, Kopek N Tags: Radiother Oncol Source Type: research

Distinct shifts in the oral microbiota are associated with the progression and aggravation of mucositis during radiotherapy.
CONCLUSION: Our results suggest that dysbiosis of oral mucosal microbiota may contribute to exacerbating the severity of mucositis in patients undergoing radiotherapy for nasopharyngeal carcinoma. PMID: 29735410 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 4, 2018 Category: Radiology Authors: Hou J, Zheng H, Li P, Liu H, Zhou H, Yang X Tags: Radiother Oncol Source Type: research

SBRT for pancreatic cancer: In regard of Bohoudi et al.
PMID: 29731159 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 3, 2018 Category: Radiology Authors: Garibaldi C, Moretti E, Russo S, Talamonti C, Villaggi E, Mancosu P, Italian Medical Physicists SBRT Working Group Tags: Radiother Oncol Source Type: research

Contouring of prostate tumors on multiparametric MRI: Evaluation of clinical delineations in a multicenter radiotherapy trial.
CONCLUSION: Regression coefficients revealed considerably different interpretations of mp-MRI in tumor contouring between institutes and demonstrated the need for contouring guidelines. Based on AUC values outlying delineations could efficiently be identified for review. PMID: 29731160 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 3, 2018 Category: Radiology Authors: van Schie MA, Dinh CV, Houdt PJV, Pos FJ, Heijmink SWTJP, Kerkmeijer LGW, Kotte ANTJ, Oyen R, Haustermans K, van der Heide UA Tags: Radiother Oncol Source Type: research

Implications of improved diagnostic imaging of small nodal metastases in head and neck cancer: Radiotherapy target volume transformation and dose de-escalation.
In this report the radiobiological consequences of target volume transformation caused by modern imaging of the neck are evaluated, and theoretically derived reductions of dose in radiotherapy for head and neck cancer are proposed. The concept of target volume transformation and subsequent strategies for dose adaptation applies to many other tumor types as well. Awareness of this concept may result in new strategies for target definition and selection of dose levels with the aim to provide optimal tumor control with less toxicity. PMID: 29731161 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : ...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 3, 2018 Category: Radiology Authors: van den Bosch S, Vogel WV, Raaijmakers CP, Dijkema T, Terhaard CHJ, Al-Mamgani A, Kaanders JHAM Tags: Radiother Oncol Source Type: research

Plan optimization for mediastinal radiotherapy: Estimation of coronary arteries motion with ECG-gated cardiac imaging and creation of compensatory expansion margins.
CONCLUSION: CA showed relevant displacements over the heart cycle, suggesting the need for a specific PRV margin to accurately estimate the dose received by these structures and optimize the planning process. PMID: 29729845 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 2, 2018 Category: Radiology Authors: Levis M, De Luca V, Fiandra C, Veglia S, Fava A, Gatti M, Giorgi M, Bartoncini S, Cadoni F, Garabello D, Ragona R, Filippi AR, Ricardi U Tags: Radiother Oncol Source Type: research

Patient safety in external beam radiotherapy, results of the ACCIRAD project: Recommendations for radiotherapy institutions and national authorities on assessing risks and analysing adverse error-events and near misses.
Abstract The ACCIRAD project, commissioned by the European Commission (EC) to develop guidelines for risk analysis of accidental and unintended exposures in external beam radiotherapy (EBRT), was completed in the year 2014. In 2015, the "General guidelines on risk management in external beam radiotherapy" were published as EC report Radiation Protection (RP)-181. The present document is the third and final report of the findings from the ACCIRAD project. The main aim of this paper is to describe the key features of the risk management process and to provide general guidelines for radiotherapy departments...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 2, 2018 Category: Radiology Authors: Malicki J, Bly R, Bulot M, Godet JL, Jahnen A, Krengli M, Maingon P, Prieto Martin C, Skrobala A, Valero M, Jarvinen H Tags: Radiother Oncol Source Type: research

SIOPE - Brain tumor group consensus guideline on craniospinal target volume delineation for high-precision radiotherapy.
CONCLUSION: This consensus guideline has the potential to improve consistency of craniospinal TV delineation in an era of high-precision radiotherapy. This proposal will be incorporated in the RTQA guidelines of future SIOPE-BTG trials using CSI. PMID: 29729847 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 2, 2018 Category: Radiology Authors: Ajithkumar T, Horan G, Padovani L, Thorp N, Timmermann B, Alapetite C, Gandola L, Ramos M, Van Beek K, Christiaens M, Lassen-Ramshad Y, Magelssen H, Nilsson K, Saran F, Rombi B, Kortmann R, Janssens GO, SIOPE BTG Radiotherapy Group Tags: Radiother Oncol Source Type: research

Submandibular function recovery after IMRT in head and neck cancer: A prospective dose modelling study.
Abstract PURPOSE: To estimate the dose response relationship for submandibular gland (SMG) recovery using salivary scintigraphy in patients diagnosed with head and neck cancer treated with curative image guided chemoradiation. MATERIAL AND METHODS: Ninety newly diagnosed head and neck cancer patients (T1-3, N0-2c, M0) treated with intensity modulated radiotherapy on a prospective clinical trial were assessed for salivary toxicity at predefined intervals using dynamic salivary scintigraphy. The SMG function was measured using salivary excretion fraction (SEF) ratios at baseline and 6 monthly. Tolerance dose (T...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 30, 2018 Category: Radiology Authors: Murthy V, Lewis S, Kannan S, Khadanga CR, Rangarajan V, Joshi K, Gandhi M, Dey S, Rokde G, Budrukkar A, Gupta T, Laskar S, Agarwal JP Tags: Radiother Oncol Source Type: research

Anal and rectal function after intensity-modulated prostate radiotherapy with endorectal balloon.
Abstract BACKGROUND AND PURPOSE: Late anorectal toxicity influences quality of life after external beam radiotherapy (EBRT) for prostate cancer. A daily inserted endorectal balloon (ERB) during EBRT aims to reduce anorectal toxicity. Our goal is to objectify anorectal function over time after prostate intensity-modulated radiotherapy (IMRT) with ERB. MATERIAL AND METHODS: Sixty men, irradiated with IMRT and an ERB, underwent barostat measurements and anorectal manometry prior to EBRT and 6 months, one year and 2 years after radiotherapy. Primary outcome measures were rectal distensibility and rectal sensi...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 28, 2018 Category: Radiology Authors: Krol R, McColl GM, Hopman WPM, Smeenk RJ Tags: Radiother Oncol Source Type: research

A secondary analysis of FDG spatio-temporal consistency in the randomized phase II PET-boost trial in stage II-III NSCLC.
CONCLUSION: FDG redistributed boosting did not reduce FDG spatial consistency from pre-treatment to post-treatment, which was highly variable among patients. The study found high numbers of patients with lung inflammation after treatment. PMID: 29709378 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 27, 2018 Category: Radiology Authors: La Fontaine M, Vogel W, van Diessen J, van Elmpt W, Reymen B, Persson G, Westman G, De Ruysscher D, Belderbos J, Sonke JJ Tags: Radiother Oncol Source Type: research

In reply to "A Long-Awaited Guideline for the Delineation of Primary Tumor in Head and Neck Cancer, and a Few Concerns about It" by Sezin Yuce Sari et al.
In reply to "A Long-Awaited Guideline for the Delineation of Primary Tumor in Head and Neck Cancer, and a Few Concerns about It" by Sezin Yuce Sari et al. Radiother Oncol. 2018 Apr 27;: Authors: Grégoire V, Grau C PMID: 29709379 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 27, 2018 Category: Radiology Authors: Grégoire V, Grau C Tags: Radiother Oncol Source Type: research

Local control and fracture risk following stereotactic body radiation therapy for non-spine bone metastases.
CONCLUSIONS: The results of this study confirm that SBRT yields high rates of long-term local control for non-spine bone metastases with a low fracture risk. PMID: 29706460 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 26, 2018 Category: Radiology Authors: Erler D, Brotherston D, Sahgal A, Cheung P, Loblaw A, Chu W, Soliman H, Chung H, Kiss A, Chow E, Poon I Tags: Radiother Oncol Source Type: research

Abnormal neuronal response to rectal and anal stimuli in patients treated with primary radiotherapy for anal cancer.
Abstract INTRODUCTION: Sphincter-sparing radiotherapy or chemoradiation (RT/CRT) have become the standard treatments for most patients with anal cancer. Unfortunately, long-term survivors often suffer from severe bowel symptoms indicating sensory dysfunction. The aim of the present study was to characterize the sensory pathways of the brain-gut axis after radiotherapy for anal cancer. METHOD: Cortical evoked potentials (CEPs) were recorded during repeated, rapid balloon distensions of the rectum and anal canal in 13 patients with anal cancer treated with radiotherapy or chemoradiation and in 17 healthy volunt...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 26, 2018 Category: Radiology Authors: Haas S, Faaborg P, Gram M, Lundby L, Brock C, Drewes AM, Laurberg S, Krogh K, Christensen P Tags: Radiother Oncol Source Type: research

Cost-effectiveness analysis of stereotactic body radiotherapy and surgery for medically operable early stage non small cell lung cancer.
CONCLUSIONS: This is the first medico-economic study evaluating SBRT and lobectomy in stage I NSCLC based on randomized studies, and our analyses suggest that SBRT is dominant over lobectomy in operable early-stage NSCLC treatment. Deterministic and probabilistic sensitivity analyses confirmed that this result was robust and that it was not modified by the assumptions made in the Markov model building. PMID: 29706462 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 26, 2018 Category: Radiology Authors: Paix A, Noel G, Falcoz PE, Levy P Tags: Radiother Oncol Source Type: research

Quality of radiotherapy services in post-Soviet countries: An IAEA survey.
CONCLUSIONS: Most countries need modernization of their radiotherapy infrastructure coupled with adequate staffing numbers and updated education programmes focusing on evidence-based medicine, quality, and safety. PMID: 29705501 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 25, 2018 Category: Radiology Authors: Rosenblatt E, Fidarova E, Ghosh S, Zubizarreta E, Unterkirhere O, Semikoz N, Sinaika V, Kim V, Karamyan N, Isayev I, Akbarov K, Lomidze D, Bondareva O, Tuzlucov P, Zardodkhonova M, Tkachev S, Kislyakova M, Alimov J, Pidlubna T, Barton M, Mackillop W Tags: Radiother Oncol Source Type: research

A long-awaited guideline for the delineation of primary tumor in head and neck cancer, and a few concerns about it.
PMID: 29703497 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 24, 2018 Category: Radiology Authors: Yuce Sari S, Yeginer M, Cengiz M Tags: Radiother Oncol Source Type: research

Automatic quantification of calcifications in the coronary arteries and thoracic aorta on radiotherapy planning CT scans of Western and Asian breast cancer patients.
CONCLUSIONS: CAC and TAC prevalence was considerable and increased with age. Deep learning software is a reliable method to automatically measure CAC and TAC on radiotherapy breast CT scans. PMID: 29703498 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 24, 2018 Category: Radiology Authors: Gernaat SAM, van Velzen SGM, Koh V, Emaus MJ, Išgum I, Lessmann N, Moes S, Jacobson A, Tan PW, Grobbee DE, van den Bongard DHJ, Tang JI, Verkooijen HM Tags: Radiother Oncol Source Type: research

Efficacy of thoracic radiotherapy in patients with stage IIIB-IV epidermal growth factor receptor-mutant lung adenocarcinomas who received and responded to tyrosine kinase inhibitor treatment.
CONCLUSIONS: Thoracic RT might be associated with overall survival in patients with unresectable stage IIIB-IV EGFR-mutant lung adenocarcinomas who received and responded to EGFR TKI treatment. PMID: 29703499 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 24, 2018 Category: Radiology Authors: Yen YC, Hsu HL, Chang JH, Lin WC, Chang YC, Chang CL, Chow JM, Yuan KS, Wu ATH, Wu SY Tags: Radiother Oncol Source Type: research

Overview of research and therapy facilities for radiobiological experimental work in particle therapy. Report from the European Particle Therapy Network radiobiology group.
en BS Abstract Particle therapy (PT) as cancer treatment, using protons or heavier ions, can provide a more favorable dose distribution compared to X-rays. While the physical characteristics of particle radiation have been the aim of intense research, less focus has been placed on the actual biological responses arising from particle irradiation. One of the biggest challenges for proton radiobiology is the RBE, with an increasing concern that the clinically-applied generic RBE-value of 1.1 is an approximation, as RBE is a complex quantity, depending on both biological and physical parameters, such as dose, LET, ce...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 24, 2018 Category: Radiology Authors: Dosanjh M, Jones B, Pawelke J, Pruschy M, Sørensen BS Tags: Radiother Oncol Source Type: research

Heart volume reduction during radiotherapy involving the thoracic region in children: An unexplained phenomenon.
Abstract BACKGROUND AND PURPOSE: Radiotherapy involving the thoracic region is associated with cardiotoxicity in long-term childhood cancer survivors. We quantified heart volume changes during radiotherapy in children (
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 24, 2018 Category: Radiology Authors: van Dijk IWEM, Visser J, Wiersma J, van Boggelen JR, Balgobind BV, Feijen EAML, Huijskens SC, Kok WEM, Kremer LCM, Rasch CRN, Bel A Tags: Radiother Oncol Source Type: research

Improving the modelling of irradiation-induced brain activation for in vivo PET verification of proton therapy.
CONCLUSIONS: Current methods used to predict proton-induced brain tissue activation can be improved with MR-based tissue classification and data-driven washout parameters, thus providing a more reliable basis for PT-PET verification. PMID: 29703502 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 24, 2018 Category: Radiology Authors: Bauer J, Chen W, Nischwitz S, Liebl J, Rieken S, Welzel T, Debus J, Parodi K Tags: Radiother Oncol Source Type: research

A novel voxel based homogeneity index: Rationale and clinical implications for whole-brain radiation therapy.
CONCLUSION: Higher sensitivity and feasibility to assess treatment plan quality using the VHI were demonstrated. First clinical implications were found in terms of compromised OS/CNS PFS for WBRT with radiation underdosage. PMID: 29699833 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 23, 2018 Category: Radiology Authors: Thieme AH, Stromberger C, Ghadjar P, Piper SK, Budach V Tags: Radiother Oncol Source Type: research

ESTRO-ACROP guideline: Interstitial multi-catheter breast brachytherapy as Accelerated Partial Breast Irradiation alone or as boost - GEC-ESTRO Breast Cancer Working Group practical recommendations.
CONCLUSIONS: Recent standards and guidelines for the use of APBI with different multi-catheter image-guided brachytherapy techniques have been defined. Different techniques are used to insert the catheters. Guidelines are mandatory to assure precise catheter insertion for coverage of the target volume and to guarantee high-quality dosimetry. The same rules apply for brachytherapy based boost irradiation for breast cancer after whole breast irradiation as well as for partial breast re-irradiation. PMID: 29691075 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 21, 2018 Category: Radiology Authors: Strnad V, Major T, Polgar C, Lotter M, Guinot JL, Gutierrez-Miguelez C, Galalae R, Van Limbergen E, Guix B, Niehoff P, Lössl K, Hannoun-Levi JM Tags: Radiother Oncol Source Type: research

Genistein sensitizes glioblastoma cells to carbon ions via inhibiting DNA-PKcs phosphorylation and subsequently repressing NHEJ and delaying HR repair pathways.
CONCLUSION: Our study demonstrated that genistein holds promise as a radiosensitizer for enhancing the efficacy of carbon ion radiotherapy against DNA-PKcs proficient GBM via inhibiting DNA-PKcs phosphorylation and subsequently repressing NHEJ and delaying HR repair pathways. PMID: 29685705 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 20, 2018 Category: Radiology Authors: Liu X, Li P, Hirayama R, Niu Y, Liu X, Chen W, Jin X, Zhang P, Ye F, Zhao T, Liu B, Li Q Tags: Radiother Oncol Source Type: research

Lung dose and the potential risk of death in postoperative radiation therapy for non-small cell lung cancer: A study using the method of stratified grouping.
CONCLUSIONS: The lung dose was associated with the risk of death in patients with non-small cell lung cancer having the same confounders. Further studies evaluating the risk of death according to the lung dose will be helpful to administer more precise and individualized postoperative radiation therapy. PMID: 29681411 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 19, 2018 Category: Radiology Authors: Heo J, Noh OK, Kim HI, Chun M, Cho O, Park RW, Yoon D, Oh YT Tags: Radiother Oncol Source Type: research

Preoperative radiotherapy and local excision of rectal cancer: Long-term results of a randomised study.
A, Chalubińska-Fendler J, Michalski W, Bujko K, Polish Colorectal Cancer Study Group Abstract BACKGROUND AND PURPOSE: It is uncertain whether local control is acceptable after preoperative radiotherapy and local excision (LE). An optimal preoperative dose/fractionation schedule has not yet been established. MATERIAL AND METHODS: In a phase III study, patients with cT1-2N0M0 or borderline cT2/T3N0M0 
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 18, 2018 Category: Radiology Authors: Wawok P, Polkowski W, Richter P, Szczepkowski M, Olędzki J, Wierzbicki R, Gach T, Rutkowski A, Dziki A, Kołodziejski L, Sopyło R, Pietrzak L, Kryński J, Wiśniowska K, Spałek M, Pawlewicz K, Polkowski M, Kowalska T, Paprota K, Jankiewicz M, Radkowski Tags: Radiother Oncol Source Type: research

Dose-response in choroidal melanoma.
gen E Abstract PURPOSE: In choroidal melanoma the radiation threshold dose for local control remains largely unknown. The present study examined a group of patients that received a wide range of minimum tumor dose in order to investigate a dose-response relationship. A literature review is performed to compare our results with available evidence in brachytherapy and charged particle external beam radiotherapy. MATERIALS AND METHODS: A retrospective study was conducted on all choroidal melanomas treated with Strontium-90 (Sr-90) at the University Hospital of Leuven between 1983 and 2012. Local failure was defi...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 18, 2018 Category: Radiology Authors: De Caluwé A, Termote K, Van Gestel D, Van Limbergen E Tags: Radiother Oncol Source Type: research

Stereotactic ablative radiotherapy after concomitant chemoradiotherapy in non-small cell lung cancer: A TITE-CRM phase 1 trial.
CONCLUSION: In the treatment of NSCLC with chemoradiotherapy followed by a stereotactic boost, the safe recommended dose in our protocol was a boost dose of 3 × 11 Gy. PMID: 29650404 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 9, 2018 Category: Radiology Authors: Doyen J, Poudenx M, Gal J, Otto J, Guerder C, Naghavi AO, Gérard A, Leysalle A, Cohen C, Padovani B, Ianessi A, Schiappa R, Chamorey E, Bondiau PY Tags: Radiother Oncol Source Type: research

Role of adjuvant external beam radiotherapy and chemotherapy in one versus two or more node-positive vulvar cancer: A National Cancer Database study.
This study sought to identify the optimal adjuvant therapy for each subset of women with node-positive disease. MATERIAL AND METHODS: The National Cancer Database (NCDB) was queried to identify women with inguinal node positive vulvar cancer. Survival analysis was performed using log-rank test, the Kaplan-Meier estimates, and Cox proportional hazards to both clarify prognosis and identify the benefit of each treatment modality in individual subsets of women. RESULTS: A total of 2779 women with inguinal node positive vulvar cancer were identified. On multivariate Cox model hazard ratio, radiotherapy yielded a surv...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 6, 2018 Category: Radiology Authors: Rydzewski NR, Kanis MJ, Donnelly ED, Lurain JR, Strauss JB Tags: Radiother Oncol Source Type: research

Physician assessed and patient reported lower limb edema after definitive radio(chemo)therapy and image-guided adaptive brachytherapy for locally advanced cervical cancer: A report from the EMBRACE study.
CONCLUSION: Severe LLE after definitive radiochemotherapy in LACC is rare. However, the risk for mild LLE is considerable, and related to patient-, diagnostic- and treatment characteristics. Less invasive diagnostic surgical procedures or non-invasive assessment, less invasive radiotherapy management and active rehabilitation are important pathways for future developments. PMID: 29631933 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 6, 2018 Category: Radiology Authors: Najjari Jamal D, Pötter R, Haie-Meder C, Lindegaard JC, Juergenliemk-Schulz IM, Mahantshetty U, Segedin B, Bruheim K, Hoskin P, Rai B, Wiebe E, Cooper R, Tanderup K, Kirchheiner K, EMBRACE collaborative group Tags: Radiother Oncol Source Type: research