Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Dose-dependent changes in cardiac function, strain and remodelling in a preclinical model of heart base irradiation
CONCLUSIONS: Functional features of RICT displayed a BED dependence in this study. GLS showed an early change at 10 weeks post-irradiation. Cardiac remodelling was observed as increases in mass and volume of the LV, further supporting our hypothesis that dose to the base of the heart drives the global heart toxicity.PMID:38301958 | DOI:10.1016/j.radonc.2024.110113 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 1, 2024 Category: Radiology Authors: Mihaela Ghita-Pettigrew Kevin S Edgar Refik Kuburas Kathryn H Brown Gerard M Walls Cecilia Facchi David J Grieve Chris J Watson Alan McWilliam Marcel van Herk Kaye J Williams Karl T Butterworth Source Type: research
DNA-dependent protein kinase regulates cytosolic double-stranded DNA secretion from irradiated macrophages to increase radiosensitivity of tumors
CONCLUSIONS: Irradiated macrophages can increase antitumor efficacy of radiotherapy through secretion of c-dsDNA under the regulation of DNA-PK.PMID:38286241 | DOI:10.1016/j.radonc.2024.110111 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 29, 2024 Category: Radiology Authors: Taerim Oh Gi-Sue Kang Hye-Ju Jo Hye-Joon Park Ye-Rim Lee G-One Ahn Source Type: research
Obstructive sleep apnea syndrome: A frequent and difficult-to-detect complication of radiotherapy for oropharyngeal cancers
Radiother Oncol. 2024 Jan 26;192:110109. doi: 10.1016/j.radonc.2024.110109. Online ahead of print.ABSTRACTThis pilot study reveals a higher prevalence of obstructive sleep apnea syndrome (OSAS) in patients treated for oropharyngeal squamous cell carcinoma with radiotherapy compared to the general population. OSAS indicators such as the Epworth Sleepiness Scale seem insufficient in the diagnostic approach to OSAS in this population and systematic screenings should be considered.PMID:38280437 | DOI:10.1016/j.radonc.2024.110109 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 27, 2024 Category: Radiology Authors: Florent Carsuzaa El éonore Chary Juliette Thariat Xavier Dufour Valentin Favier Source Type: research
Moderate hypofractionated radiotherapy for prostate cancer: 3-year toxicity results of a multicentre randomized phase 3, non-inferiority trial
CONCLUSION: This analysis confirms that both HFRT regimens are safe and equivalent in terms of acute grade ≥ 2 gastrointestinal toxicity.PMID:38278333 | DOI:10.1016/j.radonc.2024.110089 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 26, 2024 Category: Radiology Authors: V Fonteyne C Berghen C Van Praet B Vanderstraeten S Verbeke G Villeirs R Colman B Vanneste P Ost G De Meerleer N Lumen Source Type: research
Evaluating AI-generated CBCT-based synthetic CT images for target delineation in palliative treatments of pelvic bone metastasis at conventional C-arm linacs
CONCLUSION: The evaluated sCT quality allowed for accurate delineation for most targets. sCTs with insufficient quality could be identified accurately upfront. A moderate PTV margin expansion could address remaining delineation inaccuracies. Therefore, these findings support further exploration of CBCT based one-table treatments on C-arm linacs.PMID:38272314 | DOI:10.1016/j.radonc.2024.110110 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 25, 2024 Category: Radiology Authors: Nienke Hoffmans-Holtzer Alba Magallon-Baro Ilse de Pree Cleo Slagter Jiaofeng Xu Daniel Thill Manouk Olofsen-van Acht Mischa Hoogeman Steven Petit Source Type: research
DIVE-ART: A tool to guide clinicians towards dosimetrically informed volume editions of automatically segmented volumes in adaptive radiation therapy
Radiother Oncol. 2024 Jan 23;192:110108. doi: 10.1016/j.radonc.2024.110108. Online ahead of print.NO ABSTRACTPMID:38272315 | DOI:10.1016/j.radonc.2024.110108 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 25, 2024 Category: Radiology Authors: Benjamin Roberfroid John A Lee Xavier Geets Edmond Sterpin Ana M Barrag án-Montero Source Type: research
Differences in the association of time to treatment initiation and survival according to various head and neck cancer sites in a nationwide cohort
CONCLUSION: The relationship between longer TTI and decreased survival was confirmed, but slight variations in the pattern of the hazard of dying by TTI by tumour site were observed. These findings could support decisions on prioritizing treatment. However, other aspects such as extent of treatment and quality of life should be investigated further so this can also be included.PMID:38262531 | DOI:10.1016/j.radonc.2024.110107 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 23, 2024 Category: Radiology Authors: Micha ël H Frank Boukje A C van Dijk Rosanne C Schoonbeek Jaap Zindler Lot A Devriese Robert J J van Es Matthias A W Merkx Remco de Bree Source Type: research
Using multiparametric Magnetic Resonance Imaging and Prostate Specific Membrane Antigen Positron Emission Tomography to detect and delineate the gross tumour volume of intraprostatic lesions - A systematic review and meta-analysis
CONCLUSION: All of mpMRI, PSMA PET or their combination were found to have very good diagnostic outcomes for detecting IPLs. Recommendations for delineating IPLs varied based on the imaging modalities used and between research groups. Consensus guidelines for IPL delineation would help with creating consistency for focal boost radiation treatments in future studies.PMID:38262815 | DOI:10.1016/j.radonc.2023.110070 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 23, 2024 Category: Radiology Authors: Aneesh Dhar Jose de Jesus Cendejas-Gomez Lucas Castro Mendez Gabriel Boldt Eric McArthur Constantinos Zamboglou Glenn Bauman Source Type: research
Characterisation of quantitative imaging biomarkers for inflammatory and fibrotic radiation-induced lung injuries using preclinical radiomics
CONCLUSIONS: This study demonstrates the application of deep learning radiomics to establish predictive models of acute and late lung injury. This approach supports the wider application of radiomics as a non-invasive tool for detection of radiation-induced lung complications.PMID:38253201 | DOI:10.1016/j.radonc.2024.110106 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 22, 2024 Category: Radiology Authors: Kathryn H Brown Mihaela Ghita-Pettigrew Brianna N Kerr Letitia Mohamed-Smith Gerard M Walls Conor K McGarry Karl T Butterworth Source Type: research
Explainable deep learning-based survival prediction for non-small cell lung cancer patients undergoing radical radiotherapy
CONCLUSION: We show that, using pre-treatment covariables, a DL approach demonstrates superior performance over CPH and RSF for OS prediction and use explainable techniques to provide transparency and interpretability.PMID:38244779 | DOI:10.1016/j.radonc.2024.110084 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 20, 2024 Category: Radiology Authors: Joshua R Astley James M Reilly Stephen Robinson Jim M Wild Matthew Q Hatton Bilal A Tahir Source Type: research
A taskforce for national improvement of innovation implementation in radiotherapy
CONCLUSION: This study showed that RTCs experience comparable challenges when implementing innovations, thereby underlining the need for a platform to share implementation-lessons learned. The first concept of this platform was evaluated positively.PMID:38244780 | DOI:10.1016/j.radonc.2024.110105 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 20, 2024 Category: Radiology Authors: Maria Jacobs Hanneke Martinussen Rachelle Swart Anne Gubbels Maarten Dirkx Hans de Boer Gabrielle Speijer Karin Mondriaan Katrien de Jaeger Johan Cuijpers Mirjam Mast Floortje de Vreugt Liesbeth Boersma Source Type: research
MR-guided stereotactic radiotherapy of infra-diaphragmatic oligometastases: Evaluation of toxicity and dosimetric parameters
CONCLUSION: In this phase II study of MR-guided SABR of oligometastases in the infra-diaphragmatic region, we found a low incidence of toxicity despite half of the lesions being within 10 mm of a radiosensitive OAR. GI OAR D0.1cc, D1cc, and D20cc were associated with grade ≥ 2 GI toxicity.PMID:38224916 | DOI:10.1016/j.radonc.2024.110090 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 15, 2024 Category: Radiology Authors: Mette van Overeem Felter Pia Krause M øller Mirjana Josipovic Susanne N ørring Bekke Uffe Bernchou Eva Serup-Hansen Kasper Madsen Parag J Parikh Joshua Kim Poul Geertsen Claus P Behrens Ivan R Vogelius Mette P øhl Tine Schytte Gitte Fredberg Persson Source Type: research
The radiopharmaceutical radium-223 has immunomodulatory effects in patients and facilitates anti-programmed death receptor-1 therapy in murine models of bone metastatic prostate cancer
CONCLUSION: The inflammatory cytokine IL-6 and the angiogenic biomarker PlGF at baseline were promising outcome biomarkers after standard Ra223 treatment. In mouse models, Ra223 increased intratumoral CD8+ T cell infiltration and proliferation and could improve OS when combined with anti-PD-1 ICI.PMID:38224917 | DOI:10.1016/j.radonc.2024.110091 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 15, 2024 Category: Radiology Authors: Philip J Saylor Sergey V Kozin Aya Matsui Saveli I Goldberg Shuichi Aoki Kohei Shigeta Emilie Mamessier Matthew R Smith M Dror Michaelson Richard J Lee Dan G Duda Source Type: research
Sub-lobar resections for peripheral non-small cell lung cancer measuring ≤ 2 cm: Insights from recent clinical trials
Radiother Oncol. 2024 Jan 14;192:110094. doi: 10.1016/j.radonc.2024.110094. Online ahead of print.ABSTRACTThe findings of two well conducted trials that randomised 1803 patients with a peripheral non-small cell lung cancer measuring ≤ 2 cm to a lobar to sub-lobar resection have established the latter as a new standard of care. It is important for non-surgical oncologists to appreciate the details of study design and outcomes of both studies, given the possible impact they have for considerations of stereotactic ablative radiotherapy (SABR) for operable patients with early-stage NSCLC. Differences in overall survival betw...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 15, 2024 Category: Radiology Authors: Suresh Senan Famke L Schneiders Drew Moghanaki Source Type: research
Functionality of bone marrow mesenchymal stromal cells derived from head and neck cancer patients - A FDA-IND enabling study regarding MSC-based treatments for radiation-induced xerostomia
CONCLUSIONS: MSC (M) from previously treated HNC patients can be expanded for auto-transplantation and are functionally active. Furthermore IFNγ-stimulated MSC(M) express proteins implicated in salivary gland regeneration. This study provides preliminary data supporting the feasibility of using autologous MSC(M) from HNC patients to treat RT-induced salivary dysfunction.PMID:38224919 | DOI:10.1016/j.radonc.2024.110093 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 15, 2024 Category: Radiology Authors: Grace C Blitzer Cristina Paz Annemarie Glassey Olga R Ganz Jayeeta Giri Andrea Pennati Ross O Meyers Amber M Bates Kwangok P Nickel Marissa Weiss Zachary S Morris Ryan J Mattison Kimberly A McDowell Emma Croxford Richard J Chappell Tiffany A Glazer Nicole Source Type: research
