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Multi-criterial patient positioning based on dose recalculation on scatter-corrected CBCT images.
CONCLUSIONS: Dose guided patient positioning using in-room CBCT data is feasible and offers increased control over target coverage and doses to OARs. PMID: 29033253 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 12, 2017 Category: Radiology Authors: Hofmaier J, Haehnle J, Kurz C, Landry G, Maihoefer C, Schüttrumpf L, Süss P, Teichert K, Söhn M, Spahr N, Brachmann C, Weiler F, Thieke C, Küfer KH, Belka C, Parodi K, Kamp F Tags: Radiother Oncol Source Type: research

Nodal areas of potential geographic error in adjuvant radiotherapy for biliary tract cancer.
CONCLUSIONS: In view of discrepancies between pathological-surgical data and the CTVs used in common practice, there is an obvious need for international consensus guidelines. PMID: 29033254 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 12, 2017 Category: Radiology Authors: Socha J, Michalak M, Wołąkiewicz G, Kepka L Tags: Radiother Oncol Source Type: research

Multi-atlas-based segmentation of prostatic urethra from planning CT imaging to quantify dose distribution in prostate cancer radiotherapy.
Abstract BACKGROUND AND PURPOSE: Segmentation of intra-prostatic urethra for dose assessment from planning CT may help explaining urinary toxicity in prostate cancer radiotherapy. This work sought to: i) propose an automatic method for urethra segmentation in CT, ii) compare it with previously proposed surrogate models and iii) quantify the dose received by the urethra in patients treated with IMRT. MATERIALS AND METHODS: A weighted multi-atlas-based urethra segmentation method was devised from a training data set of 55 CT scans of patients receiving brachytherapy with visible urinary catheters. Leave-one-out...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 11, 2017 Category: Radiology Authors: Acosta O, Mylona E, Le Dain M, Voisin C, Lizee T, Rigaud B, Lafond C, Gnep K, de Crevoisier R Tags: Radiother Oncol Source Type: research

Characteristics of 2.5  MV beam and imaging dose to patients.
CONCLUSION: We provide dosimetric data, as well as estimates of organ imaging doses, for this 2.5 MV beam. When clinical default imaging protocols are used, the imaging dose from the 2.5 MV beam is about 50% of that from a 6 MV beam. The information can be used to select image procedures and to estimate organ dose from imaging procedures. PMID: 29031610 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 11, 2017 Category: Radiology Authors: Ding GX, Munro P Tags: Radiother Oncol Source Type: research

Dose to mass for evaluation and optimization of lung cancer radiation therapy.
CONCLUSIONS: DVH- and DMH-dose indices differ by>5% in lung and lung target volumes for fixed dose distributions, but optimizing DMH did not reduce dose to OARs. The primary difference observed in DVH- and DMH-optimized plans were variations in fluence to the periphery of lung target PTVs, where low density lung surrounds tumor. PMID: 29031611 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 11, 2017 Category: Radiology Authors: Tyler Watkins W, Moore JA, Hugo GD, Siebers JV Tags: Radiother Oncol Source Type: research

Tumour auto-contouring on 2d cine MRI for locally advanced lung cancer: A comparative study.
CONCLUSION: Auto-contouring of tumours on cine MRI is feasible in LA lung cancer patients. Despite large variations in implementation complexity, the different algorithms all have relatively similar performance. PMID: 29029832 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 10, 2017 Category: Radiology Authors: Fast MF, Eiben B, Menten MJ, Wetscherek A, Hawkes DJ, McClelland JR, Oelfke U Tags: Radiother Oncol Source Type: research

Interim (18)F-FDG-PET/CT during chemo-radiotherapy in the management of oesophageal cancer patients. A systematic review.
Abstract Oesophageal cancer is an aggressive disease. The possibility to early stratify patients as responsive and non-responsive with a non-invasive method is extremely appealing. The uptake of Fluorodeoxyglucose ((18)F-FDG) in tumours, provided by positron emission tomography (PET) images, has been proved to be useful to assess the initial staging of the disease, recurrence, and response to chemotherapy and chemo-radiotherapy (CRT). In the last years, efforts have been focused on the possibility to use ad interim (18)F-FDG-PET/CT (PETint) to evaluate response during radiation therapy. However, controversial find...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 10, 2017 Category: Radiology Authors: Cremonesi M, Garibaldi C, Timmerman R, Ferrari M, Ronchi S, Grana CM, Travaini L, Gilardi L, Starzyńska A, Ciardo D, Orecchia R, Jereczek-Fossa BA, Leonardi MC Tags: Radiother Oncol Source Type: research

Comparison of gamma- and DVH-based in vivo dosimetric plan evaluation for pelvic VMAT treatments.
CONCLUSIONS: Strong correlations between some γ- and DVH indicators were found. Our comparison of multi-parametric alert strategies showed clinical equivalence for γ- and DVH-based methods. PMID: 29017719 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 7, 2017 Category: Radiology Authors: van der Bijl E, van Oers RFM, Olaciregui-Ruiz I, Mans A Tags: Radiother Oncol Source Type: research

The long- and short-term variability of breathing induced tumor motion in lung and liver over the course of a radiotherapy treatment.
Abstract PURPOSE: To evaluate the short and long-term variability of breathing induced tumor motion. MATERIALS AND METHODS: 3D tumor motion of 19 lung and 18 liver lesions captured over the course of an SBRT treatment were evaluated and compared to the motion on 4D-CT. An implanted fiducial could be used for unambiguous motion information. Fast orthogonal fluoroscopy (FF) sequences, included in the treatment workflow, were used to evaluate motion during treatment. Several motion parameters were compared between different FF sequences from the same fraction to evaluate the intrafraction variability. To assess ...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 6, 2017 Category: Radiology Authors: Dhont J, Vandemeulebroucke J, Burghelea M, Poels K, Depuydt T, Van Den Begin R, Jaudet C, Collen C, Engels B, Reynders T, Boussaer M, Gevaert T, De Ridder M, Verellen D Tags: Radiother Oncol Source Type: research

Improving the quality of radiation oncology: 10years' experience of QUATRO audits in the IAEA Europe Region.
CONCLUSIONS: This analysis points to barriers to quality care such as insufficient staffing, education/training, equipment and lack of quality management. It highlights the correlation between the human resources availability and quality of care. It has also identified common action items for enhancing quality of radiotherapy programmes in the Region. PMID: 28988660 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 5, 2017 Category: Radiology Authors: Izewska J, Coffey M, Scalliet P, Zubizarreta E, Santos T, Vouldis I, Dunscombe P Tags: Radiother Oncol Source Type: research

Treating locally advanced lung cancer with a 1.5T MR-Linac - Effects of the magnetic field and irradiation geometry on conventionally fractionated and isotoxic dose-escalated radiotherapy.
CONCLUSION: It is feasible to generate treatment plans for LA NSCLC patients on a 1.5T MR-Linac. Margin reduction, facilitated by an envisioned MRI-guided workflow, enables increased OAR sparing and isotoxic target dose escalation for the respective treatment approaches. PMID: 28987747 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 4, 2017 Category: Radiology Authors: Bainbridge HE, Menten MJ, Fast MF, Nill S, Oelfke U, McDonald F Tags: Radiother Oncol Source Type: research

Consequences of introducing geometric GTV to CTV margin expansion in DAHANCA contouring guidelines for head and neck radiotherapy.
CONCLUSION: Introduction of geometric margins resulted in more uniform CTV1 and CTV2 delineation. Geometric CTV expansion was easier, left less room for misinterpretation, and resulted in more uniform treatment plans with similar irradiated high and intermediate dose volumes across all centres. PMID: 28987748 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 4, 2017 Category: Radiology Authors: Hansen CR, Johansen J, Samsøe E, Andersen E, Petersen JBB, Jensen K, Andersen LJ, Sand HMB, Bertelsen AS, Grau C Tags: Radiother Oncol Source Type: research

Different manifestation of irradiation induced coronary artery disease detected with coronary computed tomography compared with matched non-irradiated controls.
This study aimed to evaluate potential differences in the presence, extent, severity, composition and location of CAD in patients treated with mediastinal irradiation compared with non-irradiated controls matched on age, gender and cardiovascular risk factors. MATERIAL AND METHODS: Seventy-nine asymptomatic Hodgkin and non-Hodgkin lymphoma survivors, all treated with mediastinal irradiation with or without chemotherapy, who underwent coronary computed tomography angiography (CTA) to exclude or detect CAD were included. Patients were 1:3 matched with non-irradiated controls (n=237) for age, gender, diabetes, hypertensi...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 4, 2017 Category: Radiology Authors: van Rosendael AR, Daniëls LA, Dimitriu-Leen AC, Smit JM, van Rosendael PJ, Schalij MJ, Bax JJ, Scholte AJHA Tags: Radiother Oncol Source Type: research

Effects of biodegradable hydrogel spacer injection on contralateral submandibular gland sparing in radiotherapy for head and neck cancers.
Abstract Xerostomia is the most common late toxicity after head and neck radiation. We demonstrate injection of a hydrogel spacer anteriorly displacing the submandibular gland. This procedure enables reduced dose to the displaced submandibular gland in cadaveric models of oropharynx cancer treated with IMRT, with potential implications in reducing xerostomia risk. PMID: 28985953 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 3, 2017 Category: Radiology Authors: Rao AD, Coquia S, De Jong R, Gourin C, Page B, Latronico D, Dah S, Su L, Clarke S, Schultz J, Rosati LM, Fakhry C, Wong J, DeWeese TL, Quon H, Ding K, Kiess A Tags: Radiother Oncol Source Type: research

Experimental verification of dose enhancement effects in a lung phantom from inline magnetic fields.
CONCLUSIONS: This experimental work has demonstrated how strong inline magnetic fields act to enhance the dose to lower density mediums such as lung tissue. Clinically, such scenarios will arise in inline MRI-linac systems for treatment of small lung tumours. PMID: 28985954 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 3, 2017 Category: Radiology Authors: Oborn BM, Gargett MA, Causer TJ, Alnaghy SJ, Hardcastle N, Metcalfe PE, Keall PJ Tags: Radiother Oncol Source Type: research

Bladder-sparing radiotherapy for muscle-invasive bladder cancer: A survey of providers to determine barriers and enablers.
CONCLUSIONS: We have identified factors associated with referral for RT among patients with bladder cancer. These factors should be addressed as part of a concerted effort to increase utilization of RT. PMID: 28974310 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 30, 2017 Category: Radiology Authors: Walker M, French SD, Doiron RC, Brennan K, Feldman-Stewart D, Siemens DR, Mackillop WJ, Booth CM Tags: Radiother Oncol Source Type: research

Investigation of magnetic field effects on the dose-response of 3D dosimeters for magnetic resonance - image guided radiation therapy applications.
CONCLUSIONS: The percent differences in responses with and without strong magnetic fields were minimal for all three 3D dosimeter systems. These 3D dosimeters therefore can be applied to MR-IGRT without requiring a correction factor. PMID: 28964533 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 27, 2017 Category: Radiology Authors: Lee HJ, Roed Y, Venkataraman S, Carroll M, Ibbott GS Tags: Radiother Oncol Source Type: research

Preliminary results of the association of Palbociclib and radiotherapy in metastatic breast cancer patients.
PMID: 28964534 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 27, 2017 Category: Radiology Authors: Hans S, Cottu P, Kirova YM Tags: Radiother Oncol Source Type: research

(18)F-FDG PET image biomarkers improve prediction of late radiation-induced xerostomia.
CONCLUSION: Prediction of Xer12m was significantly improved with pre-treatment PET-IBMs, indicating that high metabolic parotid gland activity is associated with lower risk of developing late xerostomia. This study highlights the potential of incorporating patient-specific PET-derived functional characteristics into NTCP model development. PMID: 28951007 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 23, 2017 Category: Radiology Authors: van Dijk LV, Noordzij W, Brouwer CL, Boellaard R, Burgerhof JGM, Langendijk JA, Sijtsema NM, Steenbakkers RJHM Tags: Radiother Oncol Source Type: research

Patient-specific bolus for range shifter air gap reduction in intensity-modulated proton therapy of head-and-neck cancer studied with Monte Carlo based plan optimization.
CONCLUSIONS: Quantification of the dosimetric advantage of patient-specific bolus shows significant reductions compared to conventional RS solutions for xerostomia and dysphagia probability. These results motivate the development of a patient-specific bolus solution in IMPT for HNC. PMID: 28951008 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 23, 2017 Category: Radiology Authors: Michiels S, Barragán AM, Souris K, Poels K, Crijns W, Lee JA, Sterpin E, Nuyts S, Haustermans K, Depuydt T Tags: Radiother Oncol Source Type: research

A retrospective cohort study to assess adjuvant concurrent chemoradiation (CCRT) compared to adjuvant radiation therapy (RT) in the treatment of grade 2 and 3 extremity soft tissue sarcomas.
Abstract PURPOSE: To evaluate the efficacy and tolerance of adjuvant concurrent chemoradiation (CCRT) as treatment of grade 2 and 3 (G2-3) localized extremity soft tissue sarcomas (STS) by comparing CCRT with standard adjuvant radiation therapy (RT). PATIENTS AND METHODS: This monocentric retrospective study included non-pediatric patients (>16years) treated by adjuvant RT with or without chemotherapy (CT) after conservative resection of non-recurrent G2-3 extremity STS. RESULTS: A total of 80 patients were treated between 1990 and 2012: 51 by RT and 29 by CCRT. Of the 29 CCRT patients, 25 received do...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 23, 2017 Category: Radiology Authors: Nesseler JP, Salleron J, Rios M, Nickers P, Marchal F, Brocard F, Peiffert D, Vogin G Tags: Radiother Oncol Source Type: research

Spatiotemporal fractionation schemes for liver stereotactic body radiotherapy.
CONCLUSIONS: Spatiotemporal fractionation may reduce the risk of liver toxicity or facilitate dose escalation in liver SBRT in circumstances where the mean dose to the non-involved liver is the prescription-limiting factor. PMID: 28951010 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 23, 2017 Category: Radiology Authors: Unkelbach J, Papp D, Gaddy MR, Andratschke N, Hong T, Guckenberger M Tags: Radiother Oncol Source Type: research

Cost evaluation to optimise radiation therapy implementation in different income settings: A time-driven activity-based analysis.
CONCLUSIONS: The results indicate trends that are useful for optimising local and regional circumstances. This methodology can provide input into a uniform and accepted approach to evaluating the cost of radiotherapy. PMID: 28947098 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 22, 2017 Category: Radiology Authors: Van Dyk J, Zubizarreta E, Lievens Y Tags: Radiother Oncol Source Type: research

Radiation-induced lung toxicity in non-small-cell lung cancer: Understanding the interactions of clinical factors and cytokines with the dose-toxicity relationship.
CONCLUSIONS: Although the added prognostic benefit from cytokine data in our model was modest, understanding how clinical and biologic factors interact with the MLD-RILT relationship represents a novel framework for understanding and investigating the multiple factors contributing to radiation-induced toxicity. PMID: 28947099 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 22, 2017 Category: Radiology Authors: Hawkins PG, Boonstra PS, Hobson ST, Hearn JWD, Hayman JA, Ten Haken RK, Matuszak MM, Stanton P, Kalemkerian GP, Ramnath N, Lawrence TS, Schipper MJ, Spring Kong FM, Jolly S Tags: Radiother Oncol Source Type: research

Prognostic factors for tube feeding dependence after curative (chemo-) radiation in head and neck cancer: A systematic review of literature.
Abstract BACKGROUND: Tube feeding dependence is a commonly observed debilitating side-effect of curative (chemo-) radiation in head and neck cancer patients that severely affects quality of life. Prevention of this side-effect can be obtained using advanced radiation techniques, such as IMRT. For radiotherapy treatment plan optimization, it has become increasingly important to develop prediction models that enable clinicians to predict the risk of tube feeding dependence for individual patients. To develop such a tool, information regarding the most relevant prognostic factors for tube feeding dependence is necess...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 21, 2017 Category: Radiology Authors: Wopken K, Bijl HP, Langendijk JA Tags: Radiother Oncol Source Type: research

Radical radiation therapy for oligometastatic breast cancer: Results of a prospective phase II trial.
CONCLUSIONS: Patients with oligometastatic breast cancer treated with radical radiotherapy to all metastatic sites may achieve long-term progression-free survival, without significant treatment-related toxicity. While waiting for data from randomized trials, the use of radical radiation therapy to all metastatic sites in patients with oligometastatic breast cancer should be considered a valuable option, and its recommendation should be individualized. PMID: 28943046 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 21, 2017 Category: Radiology Authors: Trovo M, Furlan C, Polesel J, Fiorica F, Arcangeli S, Giaj-Levra N, Alongi F, Del Conte A, Militello L, Muraro E, Martorelli D, Spazzapan S, Berretta M Tags: Radiother Oncol Source Type: research

Systematic assessment of clinical outcomes and toxicities of proton radiotherapy for reirradiation.
Abstract Reirradiation (reRT) for locoregional recurrences poses unique challenges and risks; re-treatment using proton beam radiotherapy (PBT) could prove advantageous. Assessing clinical outcomes and toxicity profiles, this systematic review comprehensively evaluated available evidence regarding PBT reRT. Fourteen original investigations across central nervous system (CNS) (n=6), head/neck (H&N) (n=4), lung (n=2), and gastrointestinal (n=2) malignancies were analyzed. PBT for recurrent uveal melanoma achieved 5-year eye retention of 55%; for chordomas, reRT afforded a 2-year local control and overall surviva...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 20, 2017 Category: Radiology Authors: Verma V, Rwigema JM, Malyapa RS, Regine WF, Simone CB Tags: Radiother Oncol Source Type: research

Prostate cancer post-prostatectomy radiotherapy: CT vs MRI for vesico-urethral anastomosis target delineation.
Abstract BACKGROUND: Vesico-urethral anastomosis (VUA) is critical to the clinical target volume (CTV) in post-prostatectomy radiotherapy (PPRT), as it is the commonest site of recurrence. Typically, this is performed on a CT alone but guidelines recommend MRI. OBJECTIVE: To evaluate the VUA spatial differences between CT (ctVUA) and MRI (mrVUA) and analyse its impact on the CT defined CTV (ctCTV) as recommended by published guidelines. MATERIALS AND METHODS: We identified 34 patients with a co-registered simulation CT and T2 weighted MRI. The VUA was located on CT and MRI whilst blinded to the opposing ...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 19, 2017 Category: Radiology Authors: Lim Joon D, Lim A, Schneider M, Hiew CY, Lawrentschuk N, Sengupta S, Foroudi F, Jenkins T, Angus D, Wada M, Chao M, Khoo V Tags: Radiother Oncol Source Type: research

Heart dose associated with overall survival in locally advanced NSCLC patients treated with hypofractionated chemoradiotherapy.
Abstract Association of heart dose and overall survival was investigated in a cohort including 469 locally-advanced NSCLC patients receiving daily low-dose hypofractionated chemo-radiotherapy. Significant associations were found over a range of dose parameters. Multivariate analysis showed significant associations of heart_V2Gy:HR=1.007%(-1) (95% CI:1.002-1.013; p=0.006), age:HR=1.026year(-1) (1.011-1.042; p=0.001) and GTV volume:HR=1.001cc(-1) (1.000-1.002; p=0.006) with overall survival. PMID: 28939179 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society f...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 19, 2017 Category: Radiology Authors: Stam B, van der Bijl E, van Diessen J, Rossi MMG, Tijhuis A, Belderbos JSA, Damen E, Sonke JJ Tags: Radiother Oncol Source Type: research

What is the optimal number of library plans in ART for locally advanced cervical cancer?
CONCLUSION: Patients with large uterus motion (HD99>30mm) would benefit from an extension of the plan library to 3. HD99 is an easy-to-implement criteria to select those patients pre-treatment. PMID: 28939180 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 19, 2017 Category: Radiology Authors: Nováková E, Heijkoop ST, Quint S, Zolnay AG, Mens JWM, Godart J, Heijmen BJM, Hoogeman MS Tags: Radiother Oncol Source Type: research

Comparison of multi-leaf collimator tracking and treatment-couch tracking during stereotactic body radiation therapy of prostate cancer.
CONCLUSIONS: MLC and couch tracking at a conventional linear accelerator significantly improved the accuracy of prostate SBRT in the presence of motion, whereby couch tracking showed slightly better performance than MLC tracking. PMID: 28935181 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 18, 2017 Category: Radiology Authors: Ehrbar S, Schmid S, Jöhl A, Klöck S, Guckenberger M, Riesterer O, Tanadini-Lang S Tags: Radiother Oncol Source Type: research

A systematic review of health economic evaluation in adjuvant breast radiotherapy: Quality counted by numbers.
CONCLUSION: Quantitative CHEERS evaluation is feasible and yields comparable results to validated instruments. HEE in adjuvant breast radiotherapy is of acceptable quality, however, further efforts are needed to improve comprehensive reporting of all data, indispensable for assessing relevance, reliability and generalizability of results. PMID: 28923574 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 15, 2017 Category: Radiology Authors: Monten C, Veldeman L, Verhaeghe N, Lievens Y Tags: Radiother Oncol Source Type: research

Radioresistance of the breast tumor is highly correlated to its level of cancer stem cell and its clinical implication for breast irradiation.
CONCLUSIONS: Percentage of CSCs strongly correlated to overall tumor radioresistance. This observation suggested potential individualized radiotherapy to account for heterogeneous population of CSCs and their distinct radiosensitivity for breast cancer. PMID: 28923575 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 15, 2017 Category: Radiology Authors: Qi XS, Pajonk F, McCloskey S, Low DA, Kupelian P, Steinberg M, Sheng K Tags: Radiother Oncol Source Type: research

Dose escalation intensity-modulated radiotherapy-based concurrent chemoradiotherapy is effective for advanced-stage thoracic esophageal squamous cell carcinoma.
Abstract PURPOSE: No studies have investigated the effects of irradiation-dose escalation intensity-modulated radiotherapy (IMRT)-based concurrent chemoradiotherapy (CCRT) in patients with thoracic esophageal squamous cell carcinoma (TESCC). PATIENTS AND METHODS: We analyzed data from patients with TESCC who were enrolled in the Taiwan Cancer Registry database. To compare treatment outcomes, the patients were categorized into two groups according to their radiotherapy doses: group 1, who received CCRT
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 15, 2017 Category: Radiology Authors: Chang CL, Tsai HC, Lin WC, Chang JH, Hsu HL, Chow JM, Yuan KS, Wu ATH, Wu SY Tags: Radiother Oncol Source Type: research

Inter-observer agreement in GTV delineation of bone metastases on CT and impact of MR imaging: A multicenter study.
CONCLUSIONS: Large inter-observer variation in GTV delineation exists for CT, CT-MRI and MRI. MRI-based GTV delineation resulted in larger volumes and highest consistency between observers. PMID: 28919003 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 14, 2017 Category: Radiology Authors: Gerlich AS, van der Velden JM, Kotte ANTJ, Tseng CL, Fanetti G, Eppinga WSC, Kasperts N, Intven MPW, Pameijer FA, Philippens MEP, Verkooijen HM, Seravalli E Tags: Radiother Oncol Source Type: research

Stereotactic body radiotherapy for lung cancer patients with idiopathic interstitial pneumonias.
Abstract PURPOSE: To compare toxicity and survival after stereotactic body radiotherapy (SBRT) between lung cancer patients with or without idiopathic interstitial pneumonias (IIPs), and to investigate the potential value of SBRT for the patients. METHODS: Among lung cancer patients receiving SBRT between 2005 and 2016, we evaluated those treated with a total dose of 40-60Gy in five fractions with curative intent who either were staged as cT1-4N0M0 or experienced postoperative isolated local recurrence. We analyzed the incidence of radiation pneumonitis (RP) in all patients and local recurrence and overall su...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 14, 2017 Category: Radiology Authors: Tsurugai Y, Takeda A, Sanuki N, Enomoto T, Kaneko T, Hara Y, Mizuno T, Saeki N, Aoki Y, Oku Y, Akiba T, Kunieda E Tags: Radiother Oncol Source Type: research

Ex vivo γH2AX radiation sensitivity assay in prostate cancer: Inter-patient and intra-patient heterogeneity.
CONCLUSIONS: In prostate cancer inter-patient heterogeneity in tumour cell radiation sensitivity is pronounced and higher than intra-patient heterogeneity supporting the further development of the γH2AX ex vivo assay as a biomarker for individualized treatment. PMID: 28919005 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 14, 2017 Category: Radiology Authors: De-Colle C, Yaromina A, Hennenlotter J, Thames H, Mueller AC, Neumann T, Stenzl A, Scharpf M, Fend F, Ricardi U, Baumann M, Zips D, Menegakis A Tags: Radiother Oncol Source Type: research

Histology of non-small cell lung cancer predicts the response to stereotactic body radiotherapy.
CONCLUSION: In the current study, histologic subtypes of NSCLC predicted local control probabilities following SBRT. Prospective, multi-center studies are needed to evaluate the prognostic impact of histology and consecutively the need for SBRT dose adaptation. PMID: 28919006 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 14, 2017 Category: Radiology Authors: Hörner-Rieber J, Bernhardt D, Dern J, König L, Adeberg S, Paul A, Heussel CP, Kappes J, Hoffmann H, Herth FJP, Debus J, Warth A, Rieken S Tags: Radiother Oncol Source Type: research

Dosimetric comparison to the heart and cardiac substructure in a large cohort of esophageal cancer patients treated with proton beam therapy or Intensity-modulated radiation therapy.
Abstract PURPOSE: To compare heart and cardiac substructure radiation exposure using intensity-modulated radiotherapy (IMRT) vs. proton beam therapy (PBT) for patients with mid- to distal esophageal cancer who received chemoradiation therapy. METHODS AND MATERIALS: We identified 727 esophageal cancer patients who received IMRT (n=477) or PBT (n=250) from March 2004 to December 2015. All patients were treated to 50.4Gy with IMRT or to 50.4 cobalt Gray equivalents with PBT. IMRT and PBT dose-volume histograms (DVHs) of the whole heart, atria, ventricles, and four coronary arteries were compared. For PBT patient...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 13, 2017 Category: Radiology Authors: Shiraishi Y, Xu C, Yang J, Komaki R, Lin SH Tags: Radiother Oncol Source Type: research

BET-bromodomain inhibitors modulate epigenetic patterns at the diacylglycerol kinase alpha enhancer associated with radiation-induced fibrosis.
CONCLUSION: For the DGKA enhancer, we show that BET-bromodomain inhibitors can alter the epigenetic landscape of fibroblasts, thus counteracting profibrotic transcriptional events. Interference with epigenetic patterns of fibrosis predisposition may provide novel preventive therapies that improve radiotherapy. PMID: 28916223 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 12, 2017 Category: Radiology Authors: Valinciute G, Weigel C, Veldwijk MR, Oakes CC, Herskind C, Wenz F, Plass C, Schmezer P, Popanda O Tags: Radiother Oncol Source Type: research

Lack of differences in radiation-induced immunogenicity parameters between HPV-positive and HPV-negative human HNSCC cell lines.
CONCLUSIONS: Radiation treatment did not increase immunogenicity of HNSCC cell lines assessed by membrane CRT, ATP, HMGB1, cytokines production, and by activation of immature DCs. There was no difference between HPV-positive and HPV-negative cell lines. PMID: 28916224 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 12, 2017 Category: Radiology Authors: Schneider K, Bol V, Grégoire V Tags: Radiother Oncol Source Type: research

Stereotactic radiosurgery of early melanoma brain metastases after initiation of anti-CTL-4 treatment is associated with improved intracranial control.
CONCLUSIONS: In this multi-institutional study, patients who received SRS for new brain metastases within 5.5months after ipilimumab therapy had better intracranial disease control than those who received SRS later. Moreover, higher circulating lymphocyte count was associated with improved intracranial disease control. PMID: 28916225 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 12, 2017 Category: Radiology Authors: An Y, Jiang W, Kim BYS, Qian JM, Tang C, Fang P, Logan J, D'Souza NM, Haydu LE, Wang XA, Hess KR, Kluger H, Glitza IC, Mahajan A, Welsh JW, Lin SH, Yu JB, Davies MA, Hwu P, Sulman EP, Brown PD, Chiang VLS, Li J Tags: Radiother Oncol Source Type: research

Transcriptional-mediated effects of radiation on the expression of immune susceptibility markers in melanoma.
CONCLUSION: This study highlights time-dependent, transcription-mediated changes in tumor immune susceptibility marker expression following RT. These findings may help in the design of strategies to optimize sequencing of RT and immunotherapy in translational and clinical studies. PMID: 28893414 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 8, 2017 Category: Radiology Authors: Werner LR, Kler JS, Gressett MM, Riegert M, Werner LK, Heinze CM, Kern JG, Abbariki M, Erbe AK, Patel RB, Sriramaneni RN, Harari PM, Morris ZS Tags: Radiother Oncol Source Type: research

The prognostic value of derived neutrophil to lymphocyte ratio in oesophageal cancer treated with definitive chemoradiotherapy.
Abstract BACKGROUND AND PURPOSE: The derived neutrophil-lymphocyte ratio (dNLR) is a validated prognostic biomarker for cancer survival but has not been extensively studied in locally-advanced oesophageal cancer treated with definitive chemoradiotherapy (dCRT). We aimed to identify the prognostic value of dNLR in patients recruited to the SCOPE1 trial. MATERIALS AND METHODS: 258 patients were randomised to receive dCRT±cetuximab. Kaplan-Meier's curves and both univariable and multivariable Cox regression models were calculated for overall survival (OS), progression free survival (PFS), local PFS inside...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 8, 2017 Category: Radiology Authors: Cox S, Hurt C, Grenader T, Mukherjee S, Bridgewater J, Crosby T Tags: Radiother Oncol Source Type: research

Molecular radiation biology/oncology and its impact on preclinical and clinical research in radiotherapy.
PMID: 28888706 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 6, 2017 Category: Radiology Authors: Rodemann HP, Datta NR, Bodis S Tags: Radiother Oncol Source Type: research

A hierarchical Bayesian approach to calibrating the linear-quadratic model from clonogenic survival assay data.
Abstract We propose a Bayesian hierarchical model applicable to the calibration of the linear-quadratic model of radiation dose-response. Experimental data used in model calibration were taken from a clonogenic survival assay conducted on human breast cancer cells (MDA-MB-231) across a range of radiation doses (0-6Gy). Employing Markov-chain Monte Carlo methods, we calibrated the proposed Bayesian hierarchical model, computed posterior distributions for the model parameters and survival fraction dose-response probability densities. Key contributions include the proposal of a model that incorporates multiple source...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 1, 2017 Category: Radiology Authors: Collis J, Hill MR, Nicol JR, Paine PJ, Coulter JA Tags: Radiother Oncol Source Type: research

Dose-volume histogram analysis of brainstem necrosis in head and neck tumors treated using carbon-ion radiotherapy.
Abstract BACKGROUND AND PURPOSE: We aimed to evaluate the relationship between brainstem necrosis and dose-volume histograms in patients with head and neck tumors after carbon-ion radiotherapy. MATERIAL AND METHODS: We evaluated 85 patients with head and neck tumors who underwent carbon-ion radiotherapy and were followed-up for ≥12months. Brainstem necrosis was evaluated using the Common Terminology Criteria for Adverse Events (version 4.0). RESULTS: The median follow-up was 24months, and four patients developed grade 1 brainstem necrosis, with 2-year and 3-year cumulative rates of 2.8% and 6.5%, resp...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - August 31, 2017 Category: Radiology Authors: Shirai K, Fukata K, Adachi A, Saitoh JI, Musha A, Abe T, Kanai T, Kobayashi D, Shigeta Y, Yokoo S, Chikamatsu K, Ohno T, Nakano T Tags: Radiother Oncol Source Type: research

Treatment outcomes after reduction of the target volume of intensity-modulated radiotherapy following induction chemotherapy in patients with locoregionally advanced nasopharyngeal carcinoma: A prospective, multi-center, randomized clinical trial.
Abstract PURPOSE: To investigate whether reducing the target volume of intensity-modulated radiotherapy (IMRT) after induction chemotherapy (IC) improves the quality of life (QOL) in locoregionally advanced nasopharyngeal carcinoma (NPC) without decreasing the local control and survival rate. PATIENTS AND METHODS: A total number of 212 NPC patients staged as III-IVb were randomly assigned to group A (n=97) or group B (n=115) in this prospective clinical trial. All patients received IC followed by cisplatin concurrent with IMRT. IMRT was planned using the images of pre-IC in group A and post-IC in group B. ...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - August 29, 2017 Category: Radiology Authors: Yang H, Chen X, Lin S, Rong J, Yang M, Wen Q, Shang C, He L, Ren P, Xu S, Zhang J, Liu Q, Pang H, Shi X, Fan J, Sun X, Ma D, Tan B, Zhang T, Zhang L, Hu D, Du X, Zhang Y, Wen S, Zhang X, Wu J Tags: Radiother Oncol Source Type: research

The role of radical radiotherapy in the management of malignant pleural mesothelioma: A systematic review.
Abstract Malignant pleural mesothelioma (MPM) is a devastating disease with limited treatment options and a dismal prognosis. Attempts to employ radical radiotherapy in this disease have been limited by the complex shape of the pleura and the dose restrictions necessitated by the close proximity of radiosensitive structures. Recent shifts towards a 'lung sparing' surgical approach in MPM have further heightened these challenges. The aim of this systematic review is to assess recent advances in radiotherapy planning and delivery, to ascertain how these developments have impacted on the feasibility of delivering pho...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - August 28, 2017 Category: Radiology Authors: Ashton M, O'Rourke N, Currie S, Rimner A, Chalmers A Tags: Radiother Oncol Source Type: research

Evaluation of high dose volumetric CT to reduce inter-observer delineation variability and PTV margins for prostate cancer radiotherapy.
CONCLUSION: Inter-observer variability in delineation remains an important source of systematic error. HDCTV for treatment planning reduces this error without recourse to MRI and permits a PTV reduction of 2mm at the apex. The margins required to account for residual error with any imaging modality are still greater than are used in typical current practice. PMID: 28859933 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - August 28, 2017 Category: Radiology Authors: Alasti H, Cho YB, Catton C, Berlin A, Chung P, Bayley A, Vandermeer A, Kong V, Jaffray D Tags: Radiother Oncol Source Type: research