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Inhibition of ataxia telangiectasia related-3 (ATR) improves therapeutic index in preclinical models of non-small cell lung cancer (NSCLC) radiotherapy.
CONCLUSION: Inhibition of ATR with AZD6738 in combination with radiotherapy increases tumour growth delay without observable augmentation of late radiation induced toxicity further underpinning translation towards clinical evaluation in NSCLC. PMID: 28697853 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 8, 2017 Category: Radiology Authors: Dunne V, Ghita M, Small DM, Coffey CBM, Weldon S, Taggart CC, Osman SO, McGarry CK, Prise KM, Hanna GG, Butterworth KT Tags: Radiother Oncol Source Type: research

A prospective study of proton reirradiation for recurrent and secondary soft tissue sarcoma.
CONCLUSIONS: Proton reirradiation of recurrent/secondary soft tissue sarcomas is well tolerated. While longer follow-up is needed, early survival outcomes in this high-risk population are encouraging. PMID: 28697854 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 8, 2017 Category: Radiology Authors: Guttmann DM, Frick MA, Carmona R, Deville C, Levin WP, Berman AT, Chinniah C, Hahn SM, Plastaras JP, Simone CB Tags: Radiother Oncol Source Type: research

Reply to Nevens et al.
PMID: 28693883 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 7, 2017 Category: Radiology Authors: Amdur RJ, Dagan R, Mendenhall WM Tags: Radiother Oncol Source Type: research

Heterogeneous FDG-guided dose-escalation for locally advanced NSCLC (the NARLAL2 trial): Design and early dosimetric results of a randomized, multi-centre phase-III study.
CONCLUSIONS: FDG-driven inhomogeneous dose-escalation achieves large increment in tumour and lymph node dose, while delivering similar doses to normal tissue as homogenous standard plans. PMID: 28688525 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 5, 2017 Category: Radiology Authors: Møller DS, Nielsen TB, Brink C, Hoffmann L, Lutz CM, Drøgemüller Lund M, Hansen O, Schytte T, Khalil AA, Knap MM, Nyhus CH, Ottosson W, Sibolt P, Borissova S, Josipovic M, Persson G, Appelt AL Tags: Radiother Oncol Source Type: research

Multi-centre audit of VMAT planning and pre-treatment verification.
CONCLUSIONS: All plans fulfilled dosimetric constraints, but plan quality and complexity did not correlate and were strongly dependent on the planner and the vendor. In-house measurements cannot completely replace external audits for credentialing. PMID: 28687395 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 4, 2017 Category: Radiology Authors: Jurado-Bruggeman D, Hernández V, Sáez J, Navarro D, Pino F, Martínez T, Alayrach ME, Ailleres N, Melero A, Jornet N Tags: Radiother Oncol Source Type: research

The impact of histology on recurrence patterns in esophageal cancer treated with definitive chemoradiotherapy.
Abstract BACKGROUND: To assess the impact of histology on recurrence patterns and survival outcomes in patients with esophageal cancer (EC) treated with definitive chemoradiotherapy (CRT). METHODS: We analyzed 590 consecutive EC patients who received definitive CRT from 1998 to 2014, including 182 patients (30.8%) with squamous cell carcinoma (SCC) and 408 (69.2%) with adenocarcinoma. Recurrence pattern and timing, survival, and potential prognostic factors were compared. RESULTS: After a median follow-up time of 58.0months, the SCC group demonstrated a comparable locoregional recurrence rate (42.9% vs. ...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 4, 2017 Category: Radiology Authors: Xi M, Xu C, Liao Z, Hofstetter WL, Blum Murphy M, Maru DM, Bhutani MS, Lee JH, Weston B, Komaki R, Lin SH Tags: Radiother Oncol Source Type: research

ESTRO ACROP consensus guideline on implementation and practice of stereotactic body radiotherapy for peripherally located early stage non-small cell lung cancer.
len D Abstract BACKGROUND: Stereotactic body radiotherapy (SBRT) has become the standard of care for medically inoperable patients with peripherally located, early stage non-small cell lung cancer (NSCLC), and for those refusing surgical resection. Despite the availability of national and international guidelines, there exists substantial variability in many aspects of SBRT practice. METHODS: The ESTRO ACROP guideline is based on a questionnaire covering all aspects of SBRT implementation and practice (n=114 items). The questionnaire was answered by the 11 faculty members of the ESTRO course "Clinical pr...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 4, 2017 Category: Radiology Authors: Guckenberger M, Andratschke N, Dieckmann K, Hoogeman MS, Hoyer M, Hurkmans C, Lang S, Lartigau E, Méndez Romero A, Senan S, Verellen D Tags: Radiother Oncol Source Type: research

The impact of comorbidities on the benefits of prolonged androgen ablation in patients with T3-4 prostate cancer treated with external beam radiation therapy.
Abstract PURPOSE: To determine whether the survival benefit associated with prolonged androgen deprivation therapy (ADT) and radiotherapy (EBRT) varies with baseline estimates of overall survival in cT3-4 prostate cancer patients (PCa). METHODS AND MATERIALS: In 1997, the BC Cancer Agency adopted as standard a policy of prolonged ADT (>18months) with EBRT for locally advanced PCa. Two cohorts of cT3-T4 PCa treated with EBRT were selected: 1993-1995 (early: N=725) and 1999-2001 (late: N=584). Duration of ADT and baseline prognostic factors (age, clinical stage, grade, presenting PSA, and Charlson index (CCI...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 4, 2017 Category: Radiology Authors: Tran E, Paquette M, Jay J, Hamm J, Liu M, Duncan G, Pickles T, Tyldesley S Tags: Radiother Oncol Source Type: research

New perspectives for patients with primary CNS lymphoma.
PMID: 28687399 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 4, 2017 Category: Radiology Authors: Fabbri A, Cencini E, Cerase A, Bocchia M Tags: Radiother Oncol Source Type: research

Phase I dose escalation study of concurrent palliative radiation therapy with sorafenib in three anatomical cohorts (Thorax, Abdomen, Pelvis): The TAP study.
CONCLUSIONS: The MTD of sorafenib when used with 30Gy in 10 fractions was not established due to sorafenib-related systemic toxicity. Severe radiotherapy-related toxicities were also observed. These events suggest this concurrent combination does not warrant further study. PMID: 28668472 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 28, 2017 Category: Radiology Authors: Murray L, Longo J, Wan J, Chung C, Wang L, Dawson L, Milosevic M, Oza A, Brade A Tags: Radiother Oncol Source Type: research

European Organization for Research and Treatment of Cancer (EORTC) recommendations for planning and delivery of high-dose, high precision radiotherapy for lung cancer.
CONCLUSION: Recommendations for the clinical implementation of high-precision conformal radiotherapy and stereotactic body radiotherapy for lung tumours were identified from the literature. Techniques that were considered investigational at present are highlighted. PMID: 28666551 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 27, 2017 Category: Radiology Authors: De Ruysscher D, Faivre-Finn C, Moeller D, Nestle U, Hurkmans CW, Le Péchoux C, Belderbos J, Guckenberger M, Senan S, Lung Group and the Radiation Oncology Group of the European Organization for Research and Treatment of Cancer (EORTC) Tags: Radiother Oncol Source Type: research

Single-dose high-dose-rate brachytherapy compared to two and three fractions for locally advanced prostate cancer.
Abstract BACKGROUND: Single-dose high-dose-rate brachytherapy (HDR-BT), in a Phase-II study, was compared to two or three fractions in intermediate and high-risk localized prostate cancer. PATIENTS AND METHODS: 293 patients received 1×19Gy or 1×20Gy (A=49), 2×13Gy (B=138), or 3×10.5Gy (C=106) and assessed with prospective measures of serum PSA, late genitourinary (GU) and gastrointestinal (GI) morbidity using RTOG scales and the International Prostate Symptom Score (IPSS). RESULTS: Median follow-up is 49, 63 and 108months (A, B and C, respectively). At 4years biochemical relapse f...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 27, 2017 Category: Radiology Authors: Hoskin P, Rojas A, Ostler P, Hughes R, Alonzi R, Lowe G Tags: Radiother Oncol Source Type: research

The incidence of symptomatic brain metastases from extra-pulmonary small cell carcinoma: Is there a role for prophylactic cranial irradiation in a clinically relevant population cohort?
CONCLUSIONS: The incidence of brain metastases in patients with EPSCC is comparatively low, even in a cohort of patients that were suitable for PCI. Based on our analysis, we cannot recommend PCI for patients with EPSCC. PMID: 28662868 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 26, 2017 Category: Radiology Authors: De Caluwé A, Bowering G, Nichol A, Hsu F Tags: Radiother Oncol Source Type: research

Radiation and PD-1 inhibition: Favorable outcomes after brain-directed radiation.
CONCLUSIONS: Incorporation of palliative radiation does not preclude favorable outcomes in patients treated with PD-1 inhibitors; patients irradiated after the start of PD-1 inhibition can remain on therapy and demonstrate prolonged survival. Of note, patients irradiated for brain metastases demonstrate favorable outcomes compared with historical controls. PMID: 28662869 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 26, 2017 Category: Radiology Authors: Pike LRG, Bang A, Ott P, Balboni T, Taylor A, Catalano P, Rawal B, Spektor A, Krishnan M, Cagney D, Alexander B, Aizer AA, Buchbinder E, Awad M, Gandhi L, Hodi FS, Schoenfeld JD Tags: Radiother Oncol Source Type: research

Survival and central photopenia detected by fluorine-18 fluoro-deoxy-glucose positron emission tomography (FDG-PET) in patients with locoregional non-small cell lung cancer treated with radiotherapy.
Abstract BACKGROUND: Primary non-small cell lung cancer cavitation and central photopenia, detected by radiology and FDG-PET scanning respectively, are thought to be the result of tumor necrosis. Such regions may contain hypoxic but viable carcinoma cells which may be relatively radioresistant compared with fully oxygenated regions. We hypothesized that photopenic tumors treated with radiotherapy with or without chemotherapy would be associated with worse survival compared with tumors not showing central photopenia. PATIENTS AND METHODS: The data were from a prospective trial (TROG 99-05) investigating the pr...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 26, 2017 Category: Radiology Authors: Ashley Cox R, Akhurst T, Bressel M, MacManus M, Ball D Tags: Radiother Oncol Source Type: research

External validation of leukocytosis and neutrophilia as a prognostic marker in anal carcinoma treated with definitive chemoradiation.
Abstract PURPOSE: To validate the prognostic value of leukocyte disorders in anal squamous cell carcinoma (SCC) patients receiving definitive concurrent chemoradiation. MATERIALS AND METHODS: Bi-institutional clinical records from consecutive patients treated between 2001 and 2015 with definitive chemoradiation for anal SCC were retrospectively reviewed. Prognostic value of pretreatment leukocyte disorders was examined, with focus on patterns of relapse and survival. Leukocytosis and neutrophilia were defined as leukocyte or neutrophil count exceeding 10G/L and 7G/L, respectively. RESULTS: We identified ...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 26, 2017 Category: Radiology Authors: Schernberg A, Huguet F, Moureau-Zabotto L, Chargari C, Rivin Del Campo E, Schlienger M, Escande A, Touboul E, Deutsch E Tags: Radiother Oncol Source Type: research

MLC tracking for lung SABR reduces planning target volumes and dose to organs at risk.
CONCLUSION: MLC tracking showed reduction in PTV volume, superior GTV dose coverage and organ dose sparing than MidV and ITV-based strategies. PMID: 28655454 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 24, 2017 Category: Radiology Authors: Caillet V, Keall PJ, Colvill E, Hardcastle N, O'Brien R, Szymura K, Booth JT Tags: Radiother Oncol Source Type: research

Attention, processing speed, and executive functioning in pediatric brain tumor survivors treated with proton beam radiation therapy.
This study examines attention, processing speed, and executive functioning in pediatric brain tumor survivors treated with proton beam radiation therapy (PBRT). MATERIAL AND METHODS: We examined 39 survivors (age 6-19years) who were 3.61years post-PBRT on average. Craniospinal (CSI; n=21) and focal (n=18) subgroups were analyzed. Attention, processing speed, and executive functioning scores were compared to population norms, and clinical/demographic risk factors were examined. RESULTS: As a group, survivors treated with focal PBRT exhibited attention, processing speed, and executive functioning that did not diffe...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 24, 2017 Category: Radiology Authors: Antonini TN, Ris MD, Grosshans DR, Mahajan A, Okcu MF, Chintagumpala M, Paulino A, Child AE, Orobio J, Stancel HH, Kahalley LS Tags: Radiother Oncol Source Type: research

High-dose-rate brachytherapy boost for prostate cancer treatment: Different combinations of hypofractionated regimens and clinical outcomes.
CONCLUSIONS: The increase in BED with the hypofractionated regimens correlates with an improvement in biochemical control with of urinary toxicity. This increase in urinary toxicity is small and clinically acceptable. PMID: 28652094 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 23, 2017 Category: Radiology Authors: Vigneault E, Mbodji K, Magnan S, Després P, Lavallée MC, Aubin S, Beaulieu L, Foster W, Martin AG Tags: Radiother Oncol Source Type: research

Google Trends can provide objective data on the impact of radiation oncology related media events and the level of interest in specific types of treatment.
PMID: 28648722 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 22, 2017 Category: Radiology Authors: Dahele M, Tol J Tags: Radiother Oncol Source Type: research

Quantitative imaging outperforms molecular markers when predicting response to chemoradiotherapy for rectal cancer.
CONCLUSIONS: Combining (18)F-FDG PET/CT, DWI, and T2-weighted MRI volumetry obtained before CRT and prior to surgery may help physicians in selecting rectal cancer patients for organ-preservation. PMID: 28647399 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 21, 2017 Category: Radiology Authors: Joye I, Debucquoy A, Deroose CM, Vandecaveye V, Cutsem EV, Wolthuis A, D'Hoore A, Sagaert X, Zhou M, Gevaert O, Haustermans K Tags: Radiother Oncol Source Type: research

Intraoperative Registered Ultrasound and Fluoroscopy (iRUF) for dose calculation during prostate brachytherapy: Improved accuracy compared to standard ultrasound-based dosimetry.
CONCLUSIONS: iRUF approximated post-implant CT/MRI prostate and urethral dosimetry to a greater degree than USD. A phase II trial utilizing iRUF for intraoperative dynamic plan modification is underway, with the goal to confirm capability to minimize and correct for prostate underdosage not otherwise detected. PMID: 28647400 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 21, 2017 Category: Radiology Authors: Lee J, Mian OY, Le Y, Bae HJ, Burdette EC, DeWeese TL, Prince JL, Song DY Tags: Radiother Oncol Source Type: research

Human papillomavirus infection increases the chemoradiation response of esophageal squamous cell carcinoma based on P53 mutation.
Abstract BACKGROUND AND PURPOSE: A retrospective study was carried out to analyze multiple prognostic predictors, including human papillomavirus (HPV) infection for chemoradiation treatment of esophageal squamous cell carcinoma (ESCC). MATERIALS AND METHODS: DNA extracted from a total of 192 patients treated with chemoradiation for locally advanced ESCC was examined to determine HPV status by polymerase chain reaction (PCR) and P53 gene mutation by genetic sequencing. The relationships between the chemoradiation response (CRR) and overall survival (OS) rate with HPV status and P53 gene mutation were analyzed....
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 21, 2017 Category: Radiology Authors: Zhang D, Zhang W, Liu W, Mao Y, Fu Z, Liu J, Huang W, Zhang Z, An D, Li B Tags: Radiother Oncol Source Type: research

Clinical implementation of combined modulated electron and photon beams with conventional MLC for accelerated partial breast irradiation.
CONCLUSIONS: Results showed that MERT+IMRT with the MLC is a feasible and secure technique, and easy to be extended to other centers with the implementation of the adequate software for planning. PMID: 28645692 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 20, 2017 Category: Radiology Authors: Míguez C, Jiménez-Ortega E, Palma BA, Miras H, Ureba A, Arráns R, Carrasco-Peña F, Illescas-Vacas A, Leal A Tags: Radiother Oncol Source Type: research

Displacement patterns of stranded I-125 seeds after permanent brachytherapy of the prostate: Dosimetry in the operating room put into perspective.
Abstract BACKGROUND AND PURPOSE: The reliability of post-implant dosimetry in the OR depends on the geometrical variability of implant and anatomy after the procedure. The purpose was to gain detailed information on seed displacement patterns in different sectors of the prostate. MATERIALS AND METHODS: Of 33 patients with stranded seed implants the seed geometry and the dose distribution were compared between the situation in the OR just after the procedure, based on ultrasound images, and the situation after 1month, based on registered CT and MR images. RESULTS: There was a substantial displacement of v...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 17, 2017 Category: Radiology Authors: Steggerda MJ, van den Boom F, Witteveen T, Moonen LMF Tags: Radiother Oncol Source Type: research

A review of patterns of practice and clinical guidelines in the palliative radiation treatment of uncomplicated bone metastases.
CONCLUSION: Although there is some variation between groups, the majority of guidelines recommend use of SFRT and others consider it to be a reasonable alternative to MFRT. PMID: 28629871 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 16, 2017 Category: Radiology Authors: Ganesh V, Chan S, Raman S, Chow R, Hoskin P, Lam H, Wan BA, Drost L, DeAngelis C, Chow E Tags: Radiother Oncol Source Type: research

Population-based assessment of relationship between volume of practice and outcomes in head and neck cancer patients treated in a provincially coordinated radiotherapy program.
CONCLUSIONS: In our provincially coordinated radiotherapy program, there was no significant difference in survival between cancer centers after controlling for differences in rurality, physician case volume and other potential confounding variables. PMID: 28625605 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 15, 2017 Category: Radiology Authors: McLay M, Stedford A, Yurkowski E, Matlock S, Cheung W, Tran E, Berthelet E, Wu J, Olson R Tags: Radiother Oncol Source Type: research

Evaluation of clinical target volume expansion required for involved site neck radiotherapy for lymphoma to account for the absence of a pre-chemotherapy PET-CT in the radiotherapy treatment position.
CONCLUSIONS: In the absence of treatment-position PET-CT, CTV expansion cranially and caudally by 10mm and 18mm respectively, along with generous contouring in the axial plane, was required to encompass pre-chemotherapy disease. PMID: 28600083 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 6, 2017 Category: Radiology Authors: Bird D, Patel C, Scarsbrook AF, Cosgrove V, Thomas E, Gilson D, Prestwich RJD Tags: Radiother Oncol Source Type: research

Modelling duodenum radiotherapy toxicity using cohort dose-volume-histogram data.
CONCLUSIONS: LKB parameters derived using published data are shown to be consistent to those previously obtained using individual patient data, supporting a small volume-effect and dependence on exposure to high threshold dose. PMID: 28600084 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 6, 2017 Category: Radiology Authors: Holyoake DLP, Aznar M, Mukherjee S, Partridge M, Hawkins MA Tags: Radiother Oncol Source Type: research

Improved outcome of (131)I-mIBG treatment through combination with external beam radiotherapy in the SK-N-SH mouse model of neuroblastoma.
CONCLUSIONS: This study demonstrates that combining EBRT and MRT has an enhanced therapeutic effect and emphasizes the importance of treatment scheduling according to pathophysiological criteria such as tumour vessel permeability and tumour growth kinetics. PMID: 28595752 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 5, 2017 Category: Radiology Authors: Corroyer-Dulmont A, Falzone N, Kersemans V, Thompson J, Allen DP, Able S, Kartsonaki C, Malcolm J, Kinchesh P, Hill MA, Vojnovic B, Smart SC, Gaze MN, Vallis KA Tags: Radiother Oncol Source Type: research

ITV, mid-ventilation, gating or couch tracking - A comparison of respiratory motion-management techniques based on 4D dose calculations.
-Lang S Abstract PURPOSE: Respiratory motion-management techniques (MMT) aim to ensure tumor dose coverage while sparing lung tissue. Dynamic treatment-couch tracking of the moving tumor is a promising new MMT and was compared to the internal-target-volume (ITV) concept, the mid-ventilation (MidV) principle and the gating approach in a planning study based on 4D dose calculations. METHODS: For twenty patients with lung lesions, planning target volumes (PTV) were adapted to the MMT and stereotactic body radiotherapy treatments were prepared with the 65%-isodose enclosing the PTV. For tracking, three concepts f...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 3, 2017 Category: Radiology Authors: Ehrbar S, Jöhl A, Tartas A, Stark LS, Riesterer O, Klöck S, Guckenberger M, Tanadini-Lang S Tags: Radiother Oncol Source Type: research

Interfractional variability of respiration-induced esophageal tumor motion quantified using fiducial markers and four-dimensional cone-beam computed tomography.
CONCLUSIONS: The limited interfractional variability of amplitudes and trajectory shapes and small amplitude difference between 4D-CT-based and 4D-CBCT-based measurements imply that a single 4D-CT would be sufficient for predicting the respiration-induced esophageal tumor motion during the treatment course. PMID: 28579281 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 1, 2017 Category: Radiology Authors: Jin P, Hulshof MCCM, van Wieringen N, Bel A, Alderliesten T Tags: Radiother Oncol Source Type: research

A radiosensitivity gene signature and PD-L1 status predict clinical outcome of patients with invasive breast carcinoma in The Cancer Genome Atlas (TCGA) dataset.
Abstract BACKGROUND AND PURPOSE: We investigated the link between the radiosensitivity gene signature and programmed cell death ligand 1 (PD-L1) status and clinical outcome in order to identify a group of patients that would possibly receive clinical benefit of radiotherapy (RT) combined with anti-PD1/PD-L1 therapy. MATERIAL AND METHODS: We validated the identified gene signature related to radiosensitivity and analyzed the PD-L1 status of invasive breast cancer in The Cancer Genome Atlas (TCGA) dataset. To validate the gene signature, 1045 patients were selected and divided into two clusters using a consensu...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 1, 2017 Category: Radiology Authors: Jang BS, Kim IA Tags: Radiother Oncol Source Type: research

Head and neck cancer cell radiosensitization upon dual targeting of c-Abl and beta1-integrin.
Abstract Integrin-mediated cell adhesion to extracellular matrix (ECM) critically contributes to cancer cell therapy resistance and DNA double strand break (DSB) repair. c-Abl tyrosine kinase has been linked to both of these processes. Based on our previous findings indicating c-Abl hyperphosphorylation on tyrosine (Y) 412 and threonine (T) 735 upon beta1-integrin inhibition, we hypothesized c-Abl tyrosine kinase as an important mediator of beta1-integrin signaling for radioresistance. In a panel of 8 cell lines from different solid cancer types grown in 3D laminin-rich ECM cultures, we targeted beta1 integrin wit...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 31, 2017 Category: Radiology Authors: Koppenhagen P, Dickreuter E, Cordes N Tags: Radiother Oncol Source Type: research

An evaluation of motion mitigation techniques for pancreatic SBRT.
CONCLUSION: Respiratory gating is the most effective strategy for reducing motion in pancreatic SBRT, and may allow for dose escalation through a reduction in target margin. PMID: 28571887 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 29, 2017 Category: Radiology Authors: Campbell WG, Jones BL, Schefter T, Goodman KA, Miften M Tags: Radiother Oncol Source Type: research

Reply to the Letter to the Editor by Vargo et al.
PMID: 28554499 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 26, 2017 Category: Radiology Authors: Chang JS, Byun HK, Kim YB Tags: Radiother Oncol Source Type: research

The pattern of cervical lymph node metastasis in thoracic esophageal squamous cell carcinoma may affect the target decision for definitive radiotherapy.
Abstract BACKGROUND: Metastasis to lymph nodes is a key determinant of thoracic esophageal squamous cell carcinoma (TE-SCC) prognosis. We sought to identify factors linked with cervical lymph node metastasis, which could be used to inform the decision of surgical and definitive radiotherapy. METHODS: We retrospectively reviewed records from 1715 patients who had had radical esophagectomy with three-field lymphadenectomy between January 1993 and March 2007 in our hospital. All patients included in the study had pathologically confirmed TE-SCC and no clinical evidence of cervical metastasis. RESULTS: Cervi...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 24, 2017 Category: Radiology Authors: Chen J, Cai W, Zheng X, Chen Y, Lin Y, Chen X, Zhu K, Chen C Tags: Radiother Oncol Source Type: research

Intensity-modulated proton therapy and osteoradionecrosis in oropharyngeal cancer.
Abstract PURPOSE: We compared mandibular doses and osteoradionecrosis in patients with oropharyngeal cancer after intensity-modulated radiation therapy (IMRT) or intensity-modulated proton therapy (IMPT). METHODS AND MATERIALS: We identified 584 patients who received definitive radiotherapy for oropharyngeal cancer from January 2011 through June 2014 at MD Anderson Cancer Center (534 IMRT and 50 IMPT). The dosimetric variables and osteoradionecrosis were compared with Chi-square test or Fisher's exact test. RESULTS: Median follow-up time for all patients (534 IMRT and IMPT) was 33.8months (33.8months IMR...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 23, 2017 Category: Radiology Authors: Zhang W, Zhang X, Yang P, Blanchard P, Garden AS, Gunn B, Fuller CD, Chambers M, Hutcheson KA, Ye R, Lai SY, Radwan MAS, Zhu XR, Frank SJ Tags: Radiother Oncol Source Type: research

Comparison of particle beam therapy and stereotactic body radiotherapy for early stage non-small cell lung cancer: A systematic review and hypothesis-generating meta-analysis.
CONCLUSION: Although hypo-fractionated PBT may lead to additional clinical benefit when compared with photon SBRT, no statistically significant survival benefit from PBT over SBRT was observed in the treatment of ES NSCLC in this hypothesis-generating meta-analysis after adjusting for potential confounding variables. PMID: 28545956 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 22, 2017 Category: Radiology Authors: Chi A, Chen H, Wen S, Yan H, Liao Z Tags: Radiother Oncol Source Type: research

Irradiation in a flash: Unique sparing of memory in mice after whole brain irradiation with dose rates above 100Gy/s.
This study shows for the first time that normal brain tissue toxicities after WBI can be reduced with increased dose rate. Spatial memory is preserved after WBI with mean dose rates above 100Gy/s, whereas 10Gy WBI at a conventional radiotherapy dose rate (0.1Gy/s) totally impairs spatial memory. PMID: 28545957 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 22, 2017 Category: Radiology Authors: Montay-Gruel P, Petersson K, Jaccard M, Boivin G, Germond JF, Petit B, Doenlen R, Favaudon V, Bochud F, Bailat C, Bourhis J, Vozenin MC Tags: Radiother Oncol Source Type: research

Efficacy of postoperative radiation treatment for bone metastases in the extremities.
CONCLUSION: Rates of prosthesis displacement and progression of bone metastases at site of surgery were low after postoperative radiation. There were few incidences of second surgery and re-irradiation observed in the cohort. These findings provide support for the benefit of postoperative radiation. PMID: 28545958 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 22, 2017 Category: Radiology Authors: Drost L, Ganesh V, Wan BA, Raman S, Chan S, Christakis M, Tsao M, Barnes E, Ford M, Finkelstein J, Yee A, Turner A, Lam H, Chow E Tags: Radiother Oncol Source Type: research

Risk of hypothyroidism among patients with nasopharyngeal carcinoma treated with radiation therapy: A Population-Based Cohort Study.
CONCLUSION: The risk of hypothyroidism requiring thyroxin was significantly higher in NPC patients after RT than in the general Taiwanese population and HNC patients. Regular clinical and serum thyroid function tests are essential among NPC survivors after RT. PMID: 28532605 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 19, 2017 Category: Radiology Authors: Fan CY, Lin CS, Chao HL, Huang WY, Su YF, Lin KT, Tsai IJ, Kao CH Tags: Radiother Oncol Source Type: research

Verifying tumor position during stereotactic body radiation therapy delivery using (limited-arc) cone beam computed tomography imaging.
CONCLUSIONS: (Limited-arc) CBCT reconstructions of kV images acquired during irradiation can identify the dominant position of the tumor during treatment delivery. PMID: 28532606 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 19, 2017 Category: Radiology Authors: Hazelaar C, Dahele M, Scheib S, Slotman BJ, Verbakel WFAR Tags: Radiother Oncol Source Type: research

Three-dimensional intrafractional internal target motions in accelerated partial breast irradiation using three-dimensional conformal external beam radiotherapy.
CONCLUSIONS: The magnitude of the intrafractional motion was not uniform according to the direction, patients' physical characteristics, or tumour cavity location due to the baseline drift. Therefore, the intrafractional systematic movement should be properly managed. PMID: 28532607 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 19, 2017 Category: Radiology Authors: Hirata K, Yoshimura M, Mukumoto N, Nakamura M, Inoue M, Sasaki M, Fujimoto T, Yano S, Nakata M, Mizowaki T, Hiraoka M Tags: Radiother Oncol Source Type: research

Assessment of the novel online delineation workshop dummy run approach using FALCON within a European multicentre trial in cervical cancer (RAIDs).
, Deutsch E Abstract BACKGROUND AND PURPOSE: Online delineation workshops (ODW) permit training of geographically dispersed participants. The purpose is to evaluate the methodology of an ODW using FALCON to harmonize delineation within a European multicentre trial on locally advanced cervical cancer (LACC). MATERIAL AND METHODS: Two ODW included 46 clinicians (14 centres). Clinicians completed baseline (C1), guideline (C2) and final contours (C3) for external beam radiotherapy (EBRT) and brachytherapy (BT) for LACC. Interobserver and intraobserver variability was evaluated quantitatively (using the DICE index...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 19, 2017 Category: Radiology Authors: Del Campo ER, Rivera S, Martínez-Paredes M, Hupé P, Escarpa AS, Borget I, Mazeron R, Scholl S, Eito AP, Haie-Meder C, Chargari C, Deutsch E Tags: Radiother Oncol Source Type: research

Risk factors for osteonecrosis of the jaw in oral cancer patients after surgery and eventual adjuvant treatment: The potential role of chemotherapy.
Abstract BACKGROUND AND PURPOSE: To identify the risk factors for osteonecrosis of the jaw (ONJ) in oral cancer patients after surgery with and without adjuvant therapy in a nationwide, population-based study. MATERIAL AND METHODS: Using the Taiwan National Health Insurance Research Dataset, we recruited patients with newly diagnosed oral cancer between 1997 and 2011. All of them underwent primary surgery. Data regarding demographic characteristics; tooth extractions; medications; and cancer treatments, including types of mandibular surgery, radiotherapy and platinum-based chemotherapy, were collected for ana...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 19, 2017 Category: Radiology Authors: Lai TY, Wang TH, Liu CJ, Chao TF, Chen TJ, Hu YW Tags: Radiother Oncol Source Type: research

Prognostic factors of adenoid cystic carcinoma of the head and neck in carbon-ion radiotherapy: The impact of histological subtypes.
CONCLUSIONS: CIRT appears able to locally control solid growth pattern ACC in the head and neck. Improved intervention is needed to extend DMFS and OS. PMID: 28528680 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 18, 2017 Category: Radiology Authors: Ikawa H, Koto M, Takagi R, Ebner DK, Hasegawa A, Naganawa K, Takenouchi T, Nagao T, Nomura T, Shibahara T, Tsuji H, Kamada T Tags: Radiother Oncol Source Type: research

In reply to Chang et al.: Contouring guidelines for post-mastectomy radiotherapy a cry for international consensus.
PMID: 28528018 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 17, 2017 Category: Radiology Authors: Vargo JA, Beriwal S Tags: Radiother Oncol Source Type: research

Inadequate target volume delineation and local-regional recurrence after intensity-modulated radiotherapy for human papillomavirus-positive oropharynx cancer.
CONCLUSION: A significant proportion of local-regional recurrences from HPV-positive oropharyngeal cancer represented geographical misses which possibly could have been prevented with more meticulous attention to IMRT planning. This finding has important implications with respect to ongoing attempts to de-escalate radiation dose for this disease. Our data highlight the importance of robust quality assurance with careful review of target volumes prior to the initiation of IMRT. PMID: 28511960 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 13, 2017 Category: Radiology Authors: Chen AM, Chin R, Beron P, Yoshizaki T, Mikaeilian AG, Cao M Tags: Radiother Oncol Source Type: research

Survival prediction of non-small cell lung cancer patients using radiomics analyses of cone-beam CT images.
Conclusions The results show that a subset of radiomic features extracted from CT and CBCT images are interchangeable using simple linear regression. Moreover, a previously developed radiomics signature has prognostic value for overall survival in three CBCT cohorts, showing the potential of CBCT radiomics to be used as prognostic imaging biomarker. PMID: 28506693 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 12, 2017 Category: Radiology Authors: van Timmeren JE, Leijenaar RTH, van Elmpt W, Reymen B, Oberije C, Monshouwer R, Bussink J, Brink C, Hansen O, Lambin P Tags: Radiother Oncol Source Type: research