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Response to evaluation of post-lung SABR imaging: A proposed pathway
Radiother Oncol. 2024 Jan 12:110080. doi: 10.1016/j.radonc.2024.110080. Online ahead of print.NO ABSTRACTPMID:38219909 | DOI:10.1016/j.radonc.2024.110080 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 14, 2024 Category: Radiology Authors: Stephanie Gulstene David A Palma Source Type: research

The impact of transportation mode, socioeconomic deprivation and rurality on travel times to radiotherapy and surgical services for patients with prostate cancer: A national population-based evaluation
CONCLUSION: Travel times to cancer centres vary widely according to mode of transport, socioeconomic deprivation, and rurality. Policies changing the geographical configuration of cancer services should consider the impact on the expected travel times both by car and by public transport to avoid enhancing existing inequalities in access to treatment and patient outcomes.PMID:38219910 | DOI:10.1016/j.radonc.2024.110092 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 14, 2024 Category: Radiology Authors: Lu Han Richard Sullivan Alison Tree Daniel Lewis Pat Price Vijay Sangar Jan van der Meulen Ajay Aggarwal Source Type: research

Evaluation of post-lung SABR imaging: A proposed pathway
Radiother Oncol. 2024 Jan 11:110083. doi: 10.1016/j.radonc.2024.110083. Online ahead of print.NO ABSTRACTPMID:38216087 | DOI:10.1016/j.radonc.2024.110083 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 12, 2024 Category: Radiology Authors: De Bruycker Aur élie Schneiders Famke Senan Suresh Source Type: research

Worsening of 2-year patient-reported intestinal functionality after radiotherapy for prostate cancer including pelvic node irradiation
CONCLUSION: A modest but significant deterioration of two-year patient-reported intestinal symptoms from PNI compared to baseline was found. Patients experiencing more severe acute symptoms are at higher risk of symptom persistence at 2 years, with a much larger prevalence of clinically significant symptoms.PMID:38199284 | DOI:10.1016/j.radonc.2024.110088 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 10, 2024 Category: Radiology Authors: Giuseppe Sanguineti Maddalena Pavarini Fernando Munoz Alessandro Magli Domenico Cante Elisabetta Garibaldi Andrea Gebbia Barbara Noris Chiorda Giuseppe Girelli Elisa Villa Adriana Faiella Justyna Magdalena Waskiewicz Barbara Avuzzi Alice Pastorino Eugenia Source Type: research

Non-invasive decision support for clinical treatment of non-small cell lung cancer using a multiscale radiomics approach
CONCLUSIONS: We validated multiscale radiomic signatures across tumor genotypes and immunophenotypes in a multi-institutional cohort. This imaging-based biomarker offers a non-invasive approach to select patients with NSCLC who are sensitive to targeted therapies or immunotherapy, which is promising for developing personalized treatment strategies during therapy.PMID:38195018 | DOI:10.1016/j.radonc.2024.110082 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 9, 2024 Category: Radiology Authors: Xingping Zhang Guijuan Zhang Xingting Qiu Jiao Yin Wenjun Tan Xiaoxia Yin Hong Yang Hua Wang Yanchun Zhang Source Type: research

Concurrent chemoradiotherapy versus radiotherapy alone in older patients with stage II nasopharyngeal carcinoma after intensity-modulated radiotherapy: A propensity score-matched cohort study
CONCLUSION: CCRT significantly improved the survival benefits for the older patients with stage II NPC compared with IMRT alone without adding late complications, whereas increased some of the treatment-associated acute toxicities.PMID:38185256 | DOI:10.1016/j.radonc.2024.110081 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 7, 2024 Category: Radiology Authors: Fang Wang Lu Zhou Li-Jun Zhang Chang-Bin Xie Zhi-Wei Liao Xiao-Dan Lin Yue-Feng Wen Source Type: research

Intratumor genetic heterogeneity and head and neck cancer relapse
CONCLUSION: Intratumor genetic heterogeneity at the level of the cancer driver mutations might explain the discordant mutational profiles in LRs after CRT, while there are no indications in xenograft models that these changes are induced by CRT.PMID:38185257 | DOI:10.1016/j.radonc.2024.110087 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 7, 2024 Category: Radiology Authors: A S Pierik J B Poell A Brink M Stigter-van Walsum R H de Roest T Poli A Yaromin P Lambin C R Leemans R H Brakenhoff Source Type: research

Concurrent chemoradiotherapy versus radiotherapy alone in older patients with stage II Nasopharyngeal Carcinoma after Intensity-Modulated Radiotherapy: a propensity score-matched cohort study
CONCLUSION: CCRT significantly improved the survival benefits for the older patients with stage II NPC compared with IMRT alone without adding late complications, whereas increased some of the treatment-associated acute toxicities.PMID:38185256 | DOI:10.1016/j.radonc.2024.110081 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 7, 2024 Category: Radiology Authors: Fang Wang Lu Zhou Li-Jun Zhang Chang-Bin Xie Zhi-Wei Liao Xiao-Dan Lin Yue-Feng Wen Source Type: research

Intratumor genetic heterogeneity and head and neck cancer relapse
CONCLUSION: Intratumor genetic heterogeneity at the level of the cancer driver mutations might explain the discordant mutational profiles in LRs after CRT, while there are no indications in xenograft models that these changes are induced by CRT.PMID:38185257 | DOI:10.1016/j.radonc.2024.110087 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 7, 2024 Category: Radiology Authors: A S Pierik J B Poell A Brink M Stigter-van Walsum R H de Roest T Poli A Yaromin P Lambin C R Leemans R H Brakenhoff Source Type: research

Concurrent chemoradiotherapy versus radiotherapy alone in older patients with stage II Nasopharyngeal Carcinoma after Intensity-Modulated Radiotherapy: a propensity score-matched cohort study
CONCLUSION: CCRT significantly improved the survival benefits for the older patients with stage II NPC compared with IMRT alone without adding late complications, whereas increased some of the treatment-associated acute toxicities.PMID:38185256 | DOI:10.1016/j.radonc.2024.110081 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 7, 2024 Category: Radiology Authors: Fang Wang Lu Zhou Li-Jun Zhang Chang-Bin Xie Zhi-Wei Liao Xiao-Dan Lin Yue-Feng Wen Source Type: research

Intratumor genetic heterogeneity and head and neck cancer relapse
CONCLUSION: Intratumor genetic heterogeneity at the level of the cancer driver mutations might explain the discordant mutational profiles in LRs after CRT, while there are no indications in xenograft models that these changes are induced by CRT.PMID:38185257 | DOI:10.1016/j.radonc.2024.110087 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 7, 2024 Category: Radiology Authors: A S Pierik J B Poell A Brink M Stigter-van Walsum R H de Roest T Poli A Yaromin P Lambin C R Leemans R H Brakenhoff Source Type: research

Pulmonary vein dose and risk of atrial fibrillation in patients with non-small cell lung cancer following definitive radiotherapy: an NI-HEART analysis
CONCLUSION: Radiation dose to the PVs during treatment of NSCLC was associated with the onset of AF. Actively sparing the PVs during treatment planning could reduce the incidence of AF during follow-up.PMID:38184145 | DOI:10.1016/j.radonc.2024.110085 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 6, 2024 Category: Radiology Authors: Gerard M Walls Conor McCann John O'Connor Anna O'Sullivan David I Johnston Jonathan McAleese Conor K McGarry Aidan J Cole Suneil Jain Karl T Butterworth Gerard G Hanna Source Type: research

Selectively sparing of the supraclavicular area during intensity-modulated radiotherapy in nasopharyngeal carcinoma: A double-center observation study
CONCLUSION: Omitting the supraclavicular area (levels IVb and Vc) during IMRT should be safe and feasible for N1-2 disease (except N1 disease with purely RPN involvement). Well-designed multicenter prospective trials should be conducted to confirm our findings.PMID:38184146 | DOI:10.1016/j.radonc.2024.110086 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 6, 2024 Category: Radiology Authors: Qiaojuan Guo Tianzhu Lu Wanfang Huang Hanchuan Xu Quxia Zhang Yun Xiao Jing Zhong Honghui Xie Jihong Chen Jingfeng Zong Xiaochang Gong Jianji Pan Jingao Li Shaojun Lin Source Type: research

Brachytherapy for high grade prostate cancer induces distinct changes in circulating CD4 and CD8 T cells - implications for systemic control
Radiother Oncol. 2024 Jan 2:110077. doi: 10.1016/j.radonc.2023.110077. Online ahead of print.ABSTRACTThis exploratory study is a follow up to our previous investigation of immune response in the circulation of high-grade Gleason 9 prostate cancer patients treated with EBRT+BT compared to EBRT alone. Notably, EBRT+BT demonstrates the potential to elicit an effect on CD4/CD8 ratio which may attributed to improved clinical response to therapy. Our findings show promise for leveraging circulating immune cells as predictive biomarkers for radiotherapy response.PMID:38176656 | DOI:10.1016/j.radonc.2023.110077 (Source: Radiothera...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 4, 2024 Category: Radiology Authors: H Wang L Mendez G Morton A Loblaw H T Chung P Cheung A Mesci V Escueta T N Petchiny X Huang S D White M Downes D Vesprini S K Liu Source Type: research

Brachytherapy for high grade prostate cancer induces distinct changes in circulating CD4 and CD8 T cells - implications for systemic control
Radiother Oncol. 2024 Jan 2:110077. doi: 10.1016/j.radonc.2023.110077. Online ahead of print.ABSTRACTThis exploratory study is a follow up to our previous investigation of immune response in the circulation of high-grade Gleason 9 prostate cancer patients treated with EBRT+BT compared to EBRT alone. Notably, EBRT+BT demonstrates the potential to elicit an effect on CD4/CD8 ratio which may attributed to improved clinical response to therapy. Our findings show promise for leveraging circulating immune cells as predictive biomarkers for radiotherapy response.PMID:38176656 | DOI:10.1016/j.radonc.2023.110077 (Source: Radiothera...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 4, 2024 Category: Radiology Authors: H Wang L Mendez G Morton A Loblaw H T Chung P Cheung A Mesci V Escueta T N Petchiny X Huang S D White M Downes D Vesprini S K Liu Source Type: research