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Competing risk nomograms for nasopharyngeal carcinoma in the intensity-modulated radiotherapy era: A big-data, intelligence platform-based analysis.
Abstract BACKGROUND AND PURPOSE: Lacking quantitative evaluations of competing risk data of nasopharyngeal carcinoma (NPC), we aimed to evaluate the probability of NPC- and other cause-specific mortality (NPC-SM; OCSM) and develop competing risk nomograms to quantify survival differences. MATERIAL AND METHOD: Using the institutional big-data intelligence platform, 7251 NPC patients undergoing intensity-modulated radiotherapy between 2009-2014 were identified to establish nomograms based on Fine and Gray's competing risk analysis. RESULTS: The 5-year NPC-SM and OCSM of the cohort were 13.1% and 1.2%, resp...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 27, 2018 Category: Radiology Authors: Huang XD, Zhou GQ, Lv JW, Zhou HQ, Zhong CW, Wu CF, Zheng ZQ, He XJ, Peng L, Ma J, Sun Y Tags: Radiother Oncol Source Type: research

Retrospective analysis of safety profile of high-dose concurrent chemoradiotherapy for patients with oesophageal squamous cell carcinoma.
CONCLUSIONS: Compared with standard-dose CCRT, high-dose CCRT yielded more favourable local control and survival outcomes for patients with OSCC. Grades 2-3 acute oesophagitis toxicity in patients undergoing high-dose CCRT increased, whereas severe, life-threatening toxicities (>grade 3) did not. PMID: 30270099 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 27, 2018 Category: Radiology Authors: Ren X, Wang L, Han C, Ren L Tags: Radiother Oncol Source Type: research

Diabetes mellitus and radiation induced lung injury after thoracic stereotactic body radiotherapy.
We examined the association between radiographic lung changes and lung tissue dose-density response over time with clinical risk factors for RILI, such as diabetes. METHODS: 424 baseline and follow up CT scans at 3, 6, and 12 months post-treatment were analyzed in 116 patients (27 with diabetes) undergoing thoracic SBRT. Volumes of dense/hazy regions and lung parenchyma dose-density response curves were evaluated with respect to follow up time, diabetes, and other factors. RESULTS: Dense and hazy tissue regions were larger in the diabetic population, with the effect most pronounced at 3 months. Similarly, dos...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 22, 2018 Category: Radiology Authors: Kalman NS, Hugo GD, Mahon RN, Deng X, Mukhopadhyay ND, Weiss E Tags: Radiother Oncol Source Type: research

Effect of ESA as a modifier of radiotherapy in curative intended treatment of squamous cell carcinoma of the head and neck (HNSCC).
PMID: 30249347 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 21, 2018 Category: Radiology Authors: Overgaard J, Alsner J Tags: Radiother Oncol Source Type: research

Influence of PD-L1 expression in immune cells on the response to radiation therapy in patients with oropharyngeal squamous cell carcinoma.
CONCLUSIONS: In addition to tumor p16 expression, PD-L1 expression in TC and IC can be useful for predicting the response of OPSCC to radiotherapy. PMID: 30249348 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 21, 2018 Category: Radiology Authors: Fukushima Y, Someya M, Nakata K, Hori M, Kitagawa M, Hasegawa T, Tsuchiya T, Gocho T, Ikeda H, Hirohashi Y, Torigoe T, Sugita S, Hasegawa T, Himi T, Sakata KI Tags: Radiother Oncol Source Type: research

Comparison of butterfly volumetric modulated arc therapy to full arc with or without deep inspiration breath hold for the treatment of mediastinal lymphoma.
CONCLUSION: B-VMAT and DIBH are both effective in reducing organ doses and the dosimetric benefit is additive for some parameters and complementary for others. PMID: 30245037 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 20, 2018 Category: Radiology Authors: Starke A, Bowden J, Lynn R, Hall K, Hudson K, Rato A, Aldridge E, Robb D, Steele P, Brady J, Mikhaeel NG Tags: Radiother Oncol Source Type: research

MRI-based automated detection of implanted low dose rate (LDR) brachytherapy seeds using quantitative susceptibility mapping (QSM) and unsupervised machine learning (ML).
CONCLUSIONS: The proposed MRI-based workflow enabling an accurate and robust means to localize the seeds (position and orientation) upon validation on complex seed configurations, has the potential to replace the current widely practiced CT-based workflow. PMID: 30243670 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 19, 2018 Category: Radiology Authors: Nosrati R, Soliman A, Safigholi H, Hashemi M, Wronski M, Morton G, Pejović-Milić A, Stanisz G, Song WY Tags: Radiother Oncol Source Type: research

Isodose surface volumes in cervix cancer brachytherapy: Change of practice from standard (Point A) to individualized image guided adaptive (EMBRACE I) brachytherapy.
CONCLUSIONS: MR-IGABT and individualized dose prescription during EMBRACE I resulted in improved target dose coverage and decreased ISVs compared to standard plans used with classical Point A based brachytherapy. The ISVs depended strongly on CTVHR volume which demonstrates that dose adaptation was performed per individual tumour size and response during EBRT. PMID: 30243671 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 19, 2018 Category: Radiology Authors: Serban M, Kirisits C, Pötter R, de Leeuw A, Nkiwane K, Dumas I, Nesvacil N, Swamidas J, Hudej R, Lowe G, Hellebust TP, Menon G, Oinam A, Bownes P, Oosterveld B, De Brabandere M, Koedooder K, Marthinsen ABL, Lindegaard J, Tanderup K, EMBRACE Collaborative Tags: Radiother Oncol Source Type: research

Minimum breast distance largely explains individual variability in doses to contralateral breast from breast-cancer radiotherapy.
CONCLUSION: The results enable personalized assessment of CB doses from tangential whole-breast irradiation, based only on parameters assessable from CT data. This may help support clinical decision-making processes as well as analyse retrospective studies on CB risks. PMID: 30241788 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 18, 2018 Category: Radiology Authors: Kundrát P, Remmele J, Rennau H, Sebb S, Simonetto C, Eidemüller M, Wolf U, Hildebrandt G Tags: Radiother Oncol Source Type: research

External validation of an NTCP model for acute esophageal toxicity in locally advanced NSCLC patients treated with intensity-modulated (chemo-)radiotherapy.
Abstract BACKGROUND AND PURPOSE: We externally validated a previously established multivariable normal-tissue complication probability (NTCP) model for Grade ≥2 acute esophageal toxicity (AET) after intensity-modulated (chemo-)radiotherapy or volumetric-modulated arc therapy for locally advanced non-small cell lung cancer. MATERIALS AND METHODS: A total of 603 patients from five cohorts (A-E) within four different Dutch institutes were included. Using the NTCP model, containing predictors concurrent chemoradiotherapy, mean esophageal dose, gender and clinical tumor stage, the risk of Grade ≥2 AET was es...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 18, 2018 Category: Radiology Authors: Dankers FJWM, Wijsman R, Troost EGC, Tissing-Tan CJA, Kwint MH, Belderbos J, de Ruysscher D, Hendriks LE, de Geus-Oei LF, Rodwell L, Dekker A, Monshouwer R, Hoffmann AL, Bussink J Tags: Radiother Oncol Source Type: research

In response to Rydzewski NR et al. "Role of adjuvant external beam radiotherapy and chemotherapy in one versus two or more node-positive vulvar cancer: A National Cancer Database study".
In response to Rydzewski NR et al. "Role of adjuvant external beam radiotherapy and chemotherapy in one versus two or more node-positive vulvar cancer: A National Cancer Database study". Radiother Oncol. 2018 Sep 18;: Authors: van der Velden J, Fons G PMID: 30241790 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 18, 2018 Category: Radiology Authors: van der Velden J, Fons G Tags: Radiother Oncol Source Type: research

Treatment of brain metastases with stereotactic radiosurgery and immune checkpoint inhibitors: An international meta-analysis of individual patient data.
ti DM Abstract BACKGROUND AND PURPOSE: While the combination of stereotactic radiosurgery (SRS) and immune checkpoint inhibitors (ICI) is becoming more widely used in the treatment of brain metastases (BM), there is a paucity of prospective data to validate both the safety and efficacy, as well as the optimal timing of these two therapies relative to one another. METHODS: A PICOS/PRISMA/MOOSE selection protocol was used to identify 17 studies across 15 institutions in 3 countries. Inclusion criteria were patients: diagnosed with BMs; treated with SRS/ICI, either concurrently or non-concurrently; with at least...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 18, 2018 Category: Radiology Authors: Lehrer EJ, Peterson J, Brown PD, Sheehan JP, Quiñones-Hinojosa A, Zaorsky NG, Trifiletti DM Tags: Radiother Oncol Source Type: research

Validation of a novel molecular RPA classification in glioblastoma (GBM-molRPA) treated with chemoradiation: A multi-institutional collaborative study.
Abstract BACKGROUND AND PURPOSE: A novel molecular recursive partitioning analysis classification has recently been reported integrating the MGMT promoter methylation (MGMTmeth) and IDH1 mutation (IDH1mut) status for glioblastoma (GBM-molRPA) patients treated with temozolomide-based chemoradiation. The current study was initiated to validate the model in a multi-institutional study. MATERIALS AND METHODS: Four-hundred seventy-one newly diagnosed GBM patients (validation cohort) were allocated to classes I-III of the previously reported GBM-molRPA model. Of the patients, 15.7%, 56.1%, and 28.2% patients were G...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 17, 2018 Category: Radiology Authors: Wee CW, Kim IH, Park CK, Kim JW, Dho YS, Ohka F, Aoki K, Motomura K, Natsume A, Kim N, Suh CO, Chang JH, Kim SH, Cho WK, Lim DH, Nam DH, Choi JW, Kim IA, Kim CY, Oh YT, Cho O, Chung WK, Kim SH, Kim E Tags: Radiother Oncol Source Type: research

A single institutional experience of combined carbon-ion radiotherapy and chemotherapy for unresectable locally advanced pancreatic cancer.
CONCLUSIONS: The clinical results of C-ion RT for LAPC at our institution were comparable to those of a recent multi-institutional analysis. PMID: 30224179 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 14, 2018 Category: Radiology Authors: Shinoto M, Terashima K, Suefuji H, Matsunobu A, Toyama S, Fukunishi K, Shioyama Y Tags: Radiother Oncol Source Type: research

Diffusion-weighted MRI and ADC versus FET-PET and GdT1w-MRI for gross tumor volume (GTV) delineation in re-irradiation of recurrent glioblastoma.
CONCLUSION: Unexpectedly, GTV-ADClow overlapped only partially with FET-PET and GdT1w-MRI in rGBM. Moreover, GTV-ADClow correlated poorly with later rGBM-recurrences. Seeing as a restricted diffusion is known to correlate with hypercellularity, this imaging discrepancy could only be further explained in histopathological studies. PMID: 30219612 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 12, 2018 Category: Radiology Authors: Popp I, Bott S, Mix M, Oehlke O, Schimek-Jasch T, Nieder C, Nestle U, Bock M, Yuh WTC, Meyer PT, Weber WA, Urbach H, Mader I, Grosu AL Tags: Radiother Oncol Source Type: research

Prediction of overall survival after re-irradiation with stereotactic body radiation therapy for pancreatic cancer with a novel prognostic model (the SCAD score).
Abstract PURPOSE: To develop a predictive model for stratification of patients with pancreatic cancer who may achieve survival benefits from re-irradiation with stereotactic body radiation therapy (SBRT). METHODS: The score was developed based on clinical predictors of OS in 31 patients receiving two courses of SBRT with Cox proportional hazards model. Results were then validated in another cohort with 11 participants to assess the performance of the score. RESULTS: In the training cohort, the median BED10 of the first and second SBRT was 59.5 Gy (48-85.5 Gy) and 50.2 Gy (43.7-66.9 Gy) in 5-8 fra...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 11, 2018 Category: Radiology Authors: Zhu X, Li F, Ju X, Shen Y, Cao Y, Cao F, Fang F, Qing S, Jia Z, Zhang H Tags: Radiother Oncol Source Type: research

A prospective longitudinal assessment of MRI signal intensity kinetics of non-target muscles in patients with advanced stage oropharyngeal cancer in relationship to radiotherapy dose and post-treatment radiation-associated dysphagia: Preliminary findings from a randomized trial.
Abstract PURPOSE: To assess quantitative signal intensity (SI) kinetics obtained from serial MRI of swallowing muscles as a potential imaging biomarker of radiation-induced dysphagia in oropharyngeal cancer (OPC) patients receiving radiotherapy (RT). METHODS: Patients were enrolled under an IRB approved Phase II/III randomized trial. Patients underwent serial MRIs at pre-, mid-, and post-RT. Normalized T1, T1+ contrast (T1 + C), and T2 SI for swallowing muscle volumes-of-interest (VOIs) were collected and delta SI changes (Δ) were calculated. Mid- and post-RT SI relative to baseline were assessed an...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 8, 2018 Category: Radiology Authors: Joint Head and Neck Radiotherapy-MRI Development Cooperative Tags: Radiother Oncol Source Type: research

Practical clinical guidelines for contouring the trigeminal nerve (V) and its branches in head and neck cancers.
CONCLUSION: Trigeminal nerve (V) invasion is an important component of the natural history of various head and neck cancers. Recognizing the radio-anatomy and potential routes of invasion is essential for optimal contouring, as presented in these guidelines. PMID: 30206021 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 8, 2018 Category: Radiology Authors: Biau J, Dunet V, Lapeyre M, Simon C, Ozsahin M, Grégoire V, Bourhis J Tags: Radiother Oncol Source Type: research

Interdisciplinary training for cancer specialists: The time has come.
PMID: 30197152 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 6, 2018 Category: Radiology Authors: O'Higgins N, Eriksen JG, Wyld L, Benstead K Tags: Radiother Oncol Source Type: research

Good prognosis following a PSA bounce after high dose rate brachytherapy and external radiotherapy in prostate cancer.
CONCLUSION: PSA bounce after HDR-BT combined with ERT is common and associated with a good prognosis. As the relapse risk after an early bounce is very low, the findings should alert clinicians not to initiate salvage treatment too early. Research in prospective identification of PSA bounce is clinically relevant. PMID: 30193693 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 4, 2018 Category: Radiology Authors: Åström L, Sandin F, Holmberg L Tags: Radiother Oncol Source Type: research

Comparison of three moderate fractionated schedules employed in high-dose-rate brachytherapy monotherapy for clinically localized prostate cancer.
CONCLUSIONS: The 3 schedules showed equivocal outcomes in each risk group, with different toxicity profiles. HDR-BT monotherapy with these schedules is an acceptable treatment option for localized prostate cancer. PMID: 30190166 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 3, 2018 Category: Radiology Authors: Yamazaki H, Masui K, Suzuki G, Nakamura S, Yoshida K, Kotsuma T, Tanaka E, Otani K, Yoshioka Y, Ogawa K Tags: Radiother Oncol Source Type: research

A nomogram for predicting survival of patients with locally advanced pancreatic cancer treated with chemoradiotherapy.
Abstract BACKGROUND: We developed a nomogram for predicting survival of patients with locally advanced pancreatic cancer (LAPC) after concurrent chemoradiotherapy (CRT) using 18F-flurodeoxyglucose-positron emission tomography (FDG-PET) parameters and CA 19-9 levels. METHODS: Based on 426 patients with LAPC who received concurrent CRT between 2004 and 2015, we investigated significant prognostic factors for survival to build a nomogram, including the maximum standardized uptake value (SUVmax) and CA 19-9 levels. Predictive accuracy and discriminative ability were then measured. RESULTS: Median progression...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - August 31, 2018 Category: Radiology Authors: Choi SH, Park SW, Seong J Tags: Radiother Oncol Source Type: research

Texture analysis of 3D dose distributions for predictive modelling of toxicity rates in radiotherapy.
Abstract BACKGROUND AND PURPOSE: To explore the use of texture analysis (TA) features of patients' 3D dose distributions to improve prediction modelling of treatment complication rates in prostate cancer radiotherapy. MATERIAL AND METHODS: Late toxicity scores, dose distributions, and non-treatment related (NTR) predictors for late toxicity, such as age and baseline symptoms, of 351 patients of the hypofractionation arm of the HYPRO randomized trial were used in this study. Apart from DVH parameters, also TA features of rectum and bladder 3D dose distributions were used for predictive modelling of gastrointes...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - August 31, 2018 Category: Radiology Authors: Rossi L, Bijman R, Schillemans W, Aluwini S, Cavedon C, Witte M, Incrocci L, Heijmen B Tags: Radiother Oncol Source Type: research

High-resolution FLAIR MRI at 7 Tesla for treatment planning in glioblastoma patients.
Abstract Ultra-high field MRI is an emerging technique promising high-resolution images for radiotherapy planning. We compared a 7 Tesla FLAIR sequence with clinical FLAIR imaging at 3 Tesla in glioblastoma patients before radiotherapy. High-resolution 7 Tesla FLAIR imaging may enhance the depiction of organs at risk and possibly modify target volumes. PMID: 30177373 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - August 31, 2018 Category: Radiology Authors: Regnery S, Knowles BR, Paech D, Behl N, Meissner JE, Windisch P, Ben Harrabi S, Bernhardt D, Schlemmer HP, Ladd ME, Rieken S, Debus J, Adeberg S Tags: Radiother Oncol Source Type: research

X-rays can trigger the FLASH effect: Ultra-high dose-rate synchrotron light source prevents normal brain injury after whole brain irradiation in mice.
This study is the first proof of concept that the FLASH effect can be triggered by X-rays. Our results show that a 10 Gy whole-brain irradiation delivered at ultra-high dose-rate with synchrotron generated X-rays does not induce memory deficit; it reduces hippocampal cell-division impairment and induces less reactive astrogliosis. PMID: 30177374 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - August 31, 2018 Category: Radiology Authors: Montay-Gruel P, Bouchet A, Jaccard M, Patin D, Serduc R, Aim W, Petersson K, Petit B, Bailat C, Bourhis J, Bräuer-Krisch E, Vozenin MC Tags: Radiother Oncol Source Type: research

Retrospective evaluation of decision-making for pancreatic stereotactic MR-guided adaptive radiotherapy.
CONCLUSIONS: Daily-image visual review is not reliable to determine benefit or not for adaptive radiation-therapy. Online predicted plan, based on deformed and manually adjusted contours, should be generated for every fraction that is delivered using SMART in order to reliably optimize treatment plans daily. PMID: 30174107 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - August 30, 2018 Category: Radiology Authors: Tyran M, Jiang N, Cao M, Raldow A, Lamb JM, Low D, Luterstein E, Steinberg ML, Lee P Tags: Radiother Oncol Source Type: research

Could radiotherapy play a major role in misidentification of sentinel lymph node in breast cancer recurrence?
di GB Abstract Misidentification of sentinel lymph node via lymphoscintigraphy for breast cancer is an infrequent event. We analysed 35.022 consecutive procedures from a single institution and tried to find a correlation between failures of sentinel node identification and previous oncologic treatments received by the patients. PMID: 30174108 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - August 30, 2018 Category: Radiology Authors: Lissidini G, Trifirò G, Veronesi P, Grana C, Zurrida S, Galimberti V, Corso G, Vellani C, Ivaldi GB Tags: Radiother Oncol Source Type: research

Prognostic factors of colostomy free survival in patients presenting with locally advanced anal canal carcinoma: A pooled analysis of two prospective trials (KANAL 2 and ACCORD 03).
Abstract BACKGROUND: To carry out a prognosis study of the prospective studies KANAL 2 and ACCORD 03 in order to highlight new prognostic factors of colostomy-free survival in patients with locally advanced anal canal carcinoma. PATIENTS AND METHODS: KANAL 2 and ACCORD 03 were phase 2 and phase 3 multicenter trials with same inclusion criteria: anal canal squamous cell carcinoma of ≥4 cm or pelvic node involvement treated with conformal radiotherapy (45 Gy/25 fractions plus a boost) and concomitant fluorouracyl and cisplatin at weeks 1 and 5. A multivariate analysis of potential factors (patients, tumo...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - August 29, 2018 Category: Radiology Authors: Faivre JC, Peiffert D, Vendrely V, Lemanski C, Hannoun-Levi JM, Mirabel X, Stanbury T, Salleron J, Guillemin F Tags: Radiother Oncol Source Type: research

Practical contouring guidelines with an MR-based atlas of brainstem structures involved in radiation-induced nausea and vomiting.
CONCLUSIONS: This RINV-atlas was feasible and reproducible for the delineation of RINV structures on planning CT using fused MRI. It may be used to prospectively assess dose-volume relationship for RINV structures and occurrence of nausea vomiting during intracranial or head and neck irradiation. PMID: 30172454 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - August 29, 2018 Category: Radiology Authors: Beddok A, Faivre JC, Coutte A, Guévelou JL, Welmant J, Clavier JB, Guihard S, Janoray G, Calugaru V, Pointreau Y, Lacout A, Salleron J, Lefranc M, Hasboun D, Duvernoy HM, Thariat J Tags: Radiother Oncol Source Type: research

Influence of tumor-associated macrophages and HLA class I expression according to HPV status in head and neck cancer patients receiving chemo/bioradiotherapy.
Abstract BACKGROUND AND PURPOSE: To investigate the prognostic value of tumor-associated macrophages (TAM) and HLA class I expression according to HPV status in patients with head and neck squamous cell carcinoma treated with definitive radiotherapy combining cisplatin (CRT) or cetuximab (BRT). MATERIAL AND METHODS: Ninety-five patients were enrolled. The density of CD68+ cells and CD68+ CD163+ cells (further referred as M2) in the intraepithelial and the stromal compartments, respectively, as well as HLA class I expression in tumor cells, were evaluated semi-quantitatively. Correlations between biomarker exp...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - August 29, 2018 Category: Radiology Authors: Ou D, Adam J, Garberis I, Blanchard P, Nguyen F, Levy A, Casiraghi O, Gorphe P, Breuskin I, Janot F, Temam S, Scoazec JY, Deutsch E, Tao Y Tags: Radiother Oncol Source Type: research

Total-body irradiation using linac-based volumetric modulated arc therapy: Its clinical accuracy, feasibility and reliability.
CONCLUSION: Linac-based VMAT increased the dose homogeneity of TBI treatment more than extended SSD techniques. Partial cone-beam CT and optical surface-guided system assure patient positioning. DVH-based 3D patient dose verification QA was possible with linac-based VMAT showing small differences between planned and delivered doses. It is feasible, accurate, and reliable. PMID: 30172456 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - August 29, 2018 Category: Radiology Authors: Tas B, Durmus IF, Okumus A, Uzel OE, Gokce M, Goksoy HS, Ozsahin EM Tags: Radiother Oncol Source Type: research

Feasibility of markerless 3D position monitoring of the central airways using kilovoltage projection images: Managing the risks of central lung stereotactic radiotherapy.
CONCLUSIONS: High-frequency 3D PBT position verification during free-breathing is technically feasible using markerless template matching + triangulation of kilovoltage projection images acquired during gantry rotation. Applications include organ-at-risk position monitoring during central lung SBRT. PMID: 30172457 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - August 29, 2018 Category: Radiology Authors: Hazelaar C, van der Weide L, Mostafavi H, Slotman BJ, Verbakel WFAR, Dahele M Tags: Radiother Oncol Source Type: research

Predicting tumour motion during the whole radiotherapy treatment: a systematic approach for thoracic and abdominal lesions based on real time MR.
CONCLUSION: Lesions moving with small amplitude show limited amplitude variability throughout treatment, making passive motion management strategies seem adequate. However, other variations such as baseline drifts and shifts still cause significant geometrical uncertainty, favouring real-time monitoring and an active approach for all lesions influenced by respiratory motion. PMID: 30144955 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - August 22, 2018 Category: Radiology Authors: Cusumano D, Dhont J, Boldrini L, Chiloiro G, Teodoli S, Massaccesi M, Fionda B, Cellini F, Azario L, Vandemeulebroucke J, De Spirito M, Valentini V, Verellen D Tags: Radiother Oncol Source Type: research

MRI guided focal HDR brachytherapy for localized prostate cancer: Toxicity, biochemical outcome and quality of life.
Abstract PURPOSE: To describe toxicity, biochemical outcome and quality of life after MRI guided focal high dose rate brachytherapy (HDR-BT) in a single fraction of 19 Gy for localized prostate cancer. MATERIALS AND METHODS: Between May 2013 and April 2016, 30 patients were treated by MRI-guided focal HDR-BT. Patients with visible tumour on MRI were included. All patients were ≥65 years, T-stage
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - August 18, 2018 Category: Radiology Authors: Maenhout M, Peters M, Moerland MA, Meijer RP, van den Bosch MAAJ, Frank SJ, Nguyen PL, van Vulpen M, van der Voort van Zyp JRN Tags: Radiother Oncol Source Type: research

Geometric and dosimetric evaluation of atlas based auto-segmentation of cardiac structures in breast cancer patients.
CONCLUSIONS: The atlas based auto-segmentation approach delineates heart structures with sufficient accuracy for research purposes. Our results indicate that quality of auto-segmented contours cannot be determined by geometric values only. PMID: 30107948 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - August 11, 2018 Category: Radiology Authors: Kaderka R, Gillespie EF, Mundt RC, Bryant AK, Sanudo-Thomas CB, Harrison AL, Wouters EL, Moiseenko V, Moore KL, Atwood TF, Murphy JD Tags: Radiother Oncol Source Type: research

A cost-effectiveness analysis of consolidative local therapy in oligometastatic non-squamous non-small cell lung cancer (NSCLC).
CONCLUSIONS: LT may be cost-effective for selected patients with oligometastatic NSCLC responding to first-line systemic therapy. PMID: 30104008 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - August 10, 2018 Category: Radiology Authors: Panje CM, Dedes KJ, Matter-Walstra K, Schwenkglenks M, Gautschi O, Siano M, Aebersold DM, Plasswilm L, Lupatsch JE, Swiss Group for Clinical Cancer Research (SAKK) Tags: Radiother Oncol Source Type: research

Reserve stem cell population in intestinal crypts found to be consistently small by analysis of in vivo clonogenic assays with a biomathematical dynamic model.
CONCLUSION: We established a precision tool for the quantitative analysis of radiation insult to the intestinal crypts, which we employ to show that the reserve stem cell population is small, radio-resistant, and remarkably immutable against a large variety of interventions. The increased resolution of the model allows not only a reduction of the number of animals by about 75%, but also to quantify experimentally the influence of additional agents on damage and on regeneration of the stem cell niche. PMID: 30100258 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - August 9, 2018 Category: Radiology Authors: Bahn E, van Heerden M, Gueulette J, Slabbert JP, Shaw W, Debus J, Alber M Tags: Radiother Oncol Source Type: research

Does deep inspiration breath-hold prolong life? Individual risk estimates of ischaemic heart disease after breast cancer radiotherapy.
C, Corradini S Abstract PURPOSE: Aim of the current comparative modelling study was to estimate the individual radiation-induced risk for death of ischaemic heart disease (IHD) under free breathing (FB) and deep inspiration breath-hold (DIBH) in a real-world population. MATERIALS AND METHODS: Eighty-nine patients with left-sided early breast cancer were enrolled in the prospective SAVE-HEART study. For each patient three-dimensional conformal treatment plans were created in FB and DIBH and corresponding radiation-induced risks of IHD mortality were estimated based on expected survival, individual IHD risk fa...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - August 7, 2018 Category: Radiology Authors: Simonetto C, Eidemüller M, Gaasch A, Pazos M, Schönecker S, Reitz D, Kääb S, Braun M, Harbeck N, Niyazi M, Belka C, Corradini S Tags: Radiother Oncol Source Type: research

A machine learning-based prediction model of H3K27M mutations in brainstem gliomas using conventional MRI and clinical features.
CONCLUSIONS: Using conventional MRI and clinical features, we established a machine learning-based model with high accuracy and a simplified model with improved clinical utility to predict H3K27M mutations in BSGs. PMID: 30097251 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - August 7, 2018 Category: Radiology Authors: Pan CC, Liu J, Tang J, Chen X, Chen F, Wu YL, Geng YB, Xu C, Zhang X, Wu Z, Gao PY, Zhang JT, Yan H, Liao H, Zhang LW Tags: Radiother Oncol Source Type: research

Circulating cell-free DNA: A potential biomarker to differentiate inflammation and infection during radiochemotherapy.
CONCLUSION: CfDNA levels are correlated with infections during radiochemotherapy and could represent an informative complemental biomarker to drive therapeutic decision-making. Estimated levels of circulating cell-free tumour DNA (ctDNA) in plasma should be interpreted cautiously when monitoring tumour outcome by next-generation-sequencing, as confounders like infections or drug application might influence the fraction of ctDNA in total cfDNA. PMID: 30097252 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - August 7, 2018 Category: Radiology Authors: Zwirner K, Hilke FJ, Demidov G, Ossowski S, Gani C, Rieß O, Zips D, Welz S, Schroeder C Tags: Radiother Oncol Source Type: research

CT imaging during treatment improves radiomic models for patients with locally advanced head and neck cancer.
CONCLUSION: Incorporation of imaging during treatment may be a promising way to improve radiomic risk models for clinical treatment adaption, i.e., to select patients that may benefit from dose modification. PMID: 30087056 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - August 4, 2018 Category: Radiology Authors: Leger S, Zwanenburg A, Pilz K, Zschaeck S, Zöphel K, Kotzerke J, Schreiber A, Zips D, Krause M, Baumann M, Troost EGC, Richter C, Löck S Tags: Radiother Oncol Source Type: research

SPECT/CT-guided elective nodal irradiation for head and neck cancer: Estimation of clinical benefits using NTCP models.
CONCLUSIONS: Selective SPECT/CT-guided ENI results in significant dose reductions to various organs-at-risk and corresponding NTCP values, and will subsequently reduce the incidence and severity of different troublesome radiation-related toxicities and improve quality-of-life. PMID: 30087057 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - August 4, 2018 Category: Radiology Authors: de Veij Mestdagh PD, Janssen T, Lamers E, Carbaat C, Hamming-Vrieze O, Vogel WV, Sonke JJ, Al-Mamgani A Tags: Radiother Oncol Source Type: research

The prognostic value of COX-2 expression on circulating tumor cells in nasopharyngeal carcinoma: A prospective analysis.
CONCLUSION: The study demonstrated that post-therapeutic COX-2 expression on CTCs was a novel and promising prognostic indicator for NPC patients. Future studies are needed to validate our findings and further clarify the value of integrating the indicator with current clinical strategies in improving survival of NPC patients. PMID: 30082142 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - August 3, 2018 Category: Radiology Authors: Li YJ, Luo Y, Xie XQ, Li P, Wang F Tags: Radiother Oncol Source Type: research

Functional lung imaging in radiation therapy for lung cancer: A systematic review and meta-analysis.
CONCLUSION: Functional lung imaging may have potential utility in radiation therapy planning and delivery, although significant heterogeneity was identified in approaches and reporting. Recommendations have been made based on the available evidence for future functional lung trials. PMID: 30082143 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - August 3, 2018 Category: Radiology Authors: Bucknell NW, Hardcastle N, Bressel M, Hofman MS, Kron T, Ball D, Siva S Tags: Radiother Oncol Source Type: research

Intensity-modulated radiotherapy with systemic chemotherapy improves survival in patients with nonmetastatic unresectable pancreatic adenocarcinoma: A propensity score-matched, nationwide, population-based cohort study.
CONCLUSIONS: A combination of IMRT and systemic CT for the treatment of unresectable PAs might increase survival compared with CT alone. PMID: 30082144 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - August 3, 2018 Category: Radiology Authors: Lin YK, Hsieh MC, Chang CL, Chow JM, Yuan KS, Wu ATH, Wu SY Tags: Radiother Oncol Source Type: research

A national multicenter study on 1072 DCIS patients treated with breast-conserving surgery and whole breast radiotherapy (COBCG-01 study).
We reported on the 5- and 10-year local recurrence (LR) rates, overall survival, and breast cancer specific survival (BCSS) employing the Kaplan-Meier method. RESULTS: At a median follow-up of 8.4 years, 67 LR (6.3%) and 47 deaths (4.4%) were observed. LR rates at 5 and 10 years were 3.4% and 7.6%, respectively. BCSS rates at 5 and 10 years were 99.7% and 99.1%, respectively. At univariate regression analysis, postmenopausal state (p = 0.009), estrogen receptor (ER) (p = 0.0001) and progesterone receptor (p = 0.018) positivity and ET (p = 0.006) were inversely correlated with LR. Final surgical margins (FSM) status
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 31, 2018 Category: Radiology Authors: Meattini I, Pasinetti N, Meduri B, De Rose F, De Santis MC, Franco P, Lancellotta V, Rossi F, Saieva C, Desideri I, Delli Paoli C, D'Angelo E, Triggiani L, Bastiani P, Alongi F, Lozza L, Aristei C, Ricardi U, Scorsetti M, Livi L, Clinical Oncology Breast Tags: Radiother Oncol Source Type: research

Post-mastectomy radiation therapy with or without implant-based reconstruction is safe in terms of clinical target volume coverage and survival - A matched cohort study.
CONCLUSIONS: Post-mastectomy radiation therapy and implant-based reconstruction lead to minor under dosage of the target, due to the projection of the subcutaneous tissue in the presence of the implant. However, recurrence and survival rates were equally distributed among IBR+ and IBR- patients indicating that the overall treatment protocol used in our institution is safe. PMID: 30055939 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 25, 2018 Category: Radiology Authors: Bjöhle J, Onjukka E, Rintelä N, Eloranta S, Wickman M, Sandelin K, Gagliardi G, Liljegren A Tags: Radiother Oncol Source Type: research

The safety and effectiveness of stereotactic body radiotherapy for central versus ultracentral lung tumors.
CONCLUSIONS: There were no significant differences in OS, LF, or grade ≥3 toxicity between patients with central and ultracentral lung tumors. Although these results indicate that SBRT for ultracentral tumors may be safe, caution should be applied in selecting and treating these patients until the completion of large prospective trials. PMID: 30049454 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 23, 2018 Category: Radiology Authors: Chang JH, Poon I, Erler D, Zhang L, Cheung P Tags: Radiother Oncol Source Type: research

Anatomical change during radiotherapy for head and neck cancer, and its effect on delivered dose to the spinal cord.
Abstract BACKGROUND AND PURPOSE: The impact of weight loss and anatomical change during head and neck (H&N) radiotherapy on spinal cord dosimetry is poorly understood, limiting evidence-based adaptive management strategies. MATERIALS AND METHODS: 133 H&N patients treated with daily mega-voltage CT image-guidance (MVCT-IG) on TomoTherapy, were selected. Elastix software was used to deform planning scan SC contours to MVCT-IG scans, and accumulate dose. Planned (DP) and delivered (DA) spinal cord D2% (SCD2%) were compared. Univariate relationships between neck irradiation strategy (unilateral vs bilater...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 23, 2018 Category: Radiology Authors: Noble DJ, Yeap PL, Seah SYK, Harrison K, Shelley LEA, Romanchikova M, Bates AM, Zheng Y, Barnett GC, Benson RJ, Jefferies SJ, Thomas SJ, Jena R, Burnet NG Tags: Radiother Oncol Source Type: research

Clustered DNA damage concentrated in particle trajectories causes persistent large-scale rearrangements in chromatin architecture.
CONCLUSION: Clustered damage concentrated in particle trajectories causes persistent rearrangements in chromatin architecture, which may affect structural and functional organization of cell nuclei. PMID: 30049456 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 23, 2018 Category: Radiology Authors: Timm S, Lorat Y, Jakob B, Taucher-Scholz G, Rübe CE Tags: Radiother Oncol Source Type: research