Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology RSS feedThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Transition to practice in radiation oncology: Mind the gap.
CONCLUSION: There are gaps in TtP education for RO trainees with opportunities for enrichment through the forthcoming implementation of a competency-based medical education framework in 2019. The gap in perceived competency in physician-related radiotherapy tasks may be caused by the complex interaction of clinical workflow processes, people and technology that has led to ineffective integration of trainees. The data are informative to medical education leaders for the development of comprehensive TtP curricula. PMID: 31252294 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the Euro...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 25, 2019 Category: Radiology Authors: Best LR, Sengupta A, Murphy RJL, de Metz C, Trotter T, Loewen SK, Ingledew PA, Sargeant J Tags: Radiother Oncol Source Type: research

MRI-guided mid-position liver radiotherapy: Validation of image processing and registration steps.
CONCLUSION: The feasibility of an MRI-guided mid-position workflow for liver SBRT is supported by the demonstrated high precision of all image processing and registration steps. PMID: 31252295 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 25, 2019 Category: Radiology Authors: van de Lindt TN, Fast MF, van Kranen SR, Nowee ME, Jansen EM, van der Heide UA, Sonke JJ Tags: Radiother Oncol Source Type: research

Radiomics analysis of magnetic resonance imaging improves diagnostic performance of lymph node metastasis in patients with cervical cancer.
CONCLUSIONS: The decision tree, which incorporates radiomics model of T2tumor+peri and c-LN status can be potentially applied in the preoperative prediction of LNM in locally advanced cervical cancer patients. PMID: 31252296 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 25, 2019 Category: Radiology Authors: Wu Q, Wang S, Chen X, Wang Y, Dong L, Liu Z, Tian J, Wang M Tags: Radiother Oncol Source Type: research

Immunotherapy with hypofractionated radiotherapy in metastatic non-small cell lung cancer: An analysis of the National Cancer Database.
Abstract PURPOSE: Metastatic non-small cell lung cancer (NSCLC) is associated with an exceedingly poor prognosis. Recent advances in immunotherapy offer promise in enhancing overall survival (OS) in these patients. Preclinical evidence suggests that radiotherapy (RT), especially when offered in a high-dose per fraction hypofractionated RT (HRT) as in stereotactic ablative body radiotherapy (SABR), may augment the efficacy of immunotherapy. We aimed to assess the role of RT in patients with metastatic NSCLC receiving immunotherapy in a national hospital-based database. METHODS: Using the National Cancer Databa...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 25, 2019 Category: Radiology Authors: Bates JE, Morris CG, Milano MT, Yeung AR, Hoppe BS Tags: Radiother Oncol Source Type: research

Low incidence of late failure and toxicity after spine stereotactic radiosurgery: Secondary analysis of phase I/II trials with long-term follow-up.
CONCLUSION: SSRS maintains excellent disease control and a favorable late toxicity profile even among long-term survivors, with very few failures or toxicities after 2 years in this prospectively-treated population. Overall, these data support the durable control and long-term safety of SSRS with extended follow-up. PMID: 31252298 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 25, 2019 Category: Radiology Authors: Ning MS, Deegan BJ, Ho JC, Chapman BV, Bishop AJ, Allen PK, Tannir NM, Amini B, Briere TM, Wang XA, Tatsui CE, Rhines LD, Brown PD, Li J, Ghia AJ Tags: Radiother Oncol Source Type: research

Is preoperative chemoradiation in rectal cancer patients modulated by ACE inhibitors? Results from the Dutch Cancer Registry.
CONCLUSION: In this retrospective cohort, the use of ACEIs/ARBs was not associated with tumor response to preoperative chemoradiation in rectal cancer patients. Thereby, the suggested potentiating effect of ACEIS/ARBs could not be confirmed in our study. Further research could be directed to investigate a possible benefit of beta-blockers or other anti-hypertensive drugs. PMID: 31252299 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 25, 2019 Category: Radiology Authors: Rombouts AJ, Hugen N, Verhoeven RH, Kuiper JG, Poortmans PM, de Wilt JH, Nagtegaal ID Tags: Radiother Oncol Source Type: research

Radiation-induced hypoglossal nerve palsy after definitive radiotherapy for nasopharyngeal carcinoma: Clinical predictors and dose-toxicity relationship.
This study sets to evaluate its incidence and clinical predictive factors, and to propose relevant dosimetric constraints for this structure to guide radiotherapy planning. MATERIALS AND METHODS: We undertook a retrospective review of 797 NPC patients who underwent definitive intensity-modulated radiotherapy (IMRT) between 2003 and 2011. Cumulative incidence and clinical predictors for radiation-induced hypoglossal nerve palsy were evaluated. Archived radiotherapy plans were retrieved and 330 independent hypoglossal nerves were retrospectively contoured following standardized atlas. Optimal threshold analyses of dosim...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 25, 2019 Category: Radiology Authors: Chow JCH, Cheung KM, Au KH, Zee BCY, Lee J, Ngan RKC, Lee AWM, Yiu HHY, Li KWS, Leung AKC, Chan JCH, Lee FKH, Wong KH Tags: Radiother Oncol Source Type: research

Bevacizumab reduces toxicity of reirradiation in recurrent high-grade glioma.
CONCLUSION: Concomitant BEV effectively reduces treatment toxicity of reRT and should be reconsidered in future reRT protocols. PMID: 31252301 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 25, 2019 Category: Radiology Authors: Fleischmann DF, Jenn J, Corradini S, Ruf V, Herms J, Forbrig R, Unterrainer M, Thon N, Kreth FW, Belka C, Niyazi M Tags: Radiother Oncol Source Type: research

Clinical translation of FLASH radiotherapy: Why and how?
in MC Abstract Over the past decades, technological advances have transformed radiation therapy (RT) into a precise and powerful treatment for cancer patients. Nevertheless, the treatment of radiation-resistant tumors is still restricted by the dose-limiting normal tissue complications. In this context, FLASH-RT is emerging in the field. Consisting of delivering doses within an extremely short irradiation time, FLASH-RT has been identified as a promising new tool to enhance the differential effect between tumors and normal tissues. Indeed, preclinical studies on various animal models and a veterinarian clinical tr...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 25, 2019 Category: Radiology Authors: Bourhis J, Montay-Gruel P, Gonçalves Jorge P, Bailat C, Petit B, Ollivier J, Jeanneret-Sozzi W, Ozsahin M, Bochud F, Moeckli R, Germond JF, Vozenin MC Tags: Radiother Oncol Source Type: research

Reduced cognitive deficits after FLASH irradiation of whole mouse brain are associated with less hippocampal dendritic spine loss and neuroinflammation.
CONCLUSION: Reduced cognitive impairment and associated neurodegeneration were observed with FLASH compared to conventional delivery time irradiation, potentially through decreased induction of neuroinflammation, suggesting a promising approach to increasing therapeutic index in radiation therapy of brain tumors. PMID: 31253467 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 25, 2019 Category: Radiology Authors: Simmons DA, Lartey FM, Schüler E, Rafat M, King G, Kim A, Ko R, Semaan S, Gonzalez S, Jenkins M, Pradhan P, Shih Z, Wang J, von Eyben R, Graves EE, Maxim PG, Longo FM, Loo BW Tags: Radiother Oncol Source Type: research

Prognostic value of retropharyngeal lymph node metastasis laterality in nasopharyngeal carcinoma and a proposed modification to the UICC/AJCC N staging system.
CONCLUSION: Patients with NPC and unilateral RLN metastasis had better survival than did patients with bilateral RLN metastasis. Upgrading cases with bilateral RLN metastasis from N1 to N2 may help improve prognostication using the 8th AJCC system. PMID: 31195216 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 10, 2019 Category: Radiology Authors: Huang L, Zhang Y, Liu Y, Li H, Wang S, Liang S, Zhou J, Cui C, Sun Y, Chen M, Xu S, Li J, Liu L Tags: Radiother Oncol Source Type: research

Post-mastectomy intensity modulated proton therapy after immediate breast reconstruction: Initial report of reconstruction outcomes and predictors of complications.
CONCLUSIONS: IMPT following IBR spared underlying organs and had low rates of acute toxicity. Reconstruction complications are more common in irradiated breasts, and reconstructive outcomes appear comparable with photon literature. Hypofractionation was associated with higher reconstruction failure rates. Further investigation of optimal dose-fractionation after IBR is needed. PMID: 31185327 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 8, 2019 Category: Radiology Authors: Smith NL, Jethwa KR, Viehman JK, Harmsen WS, Gonuguntla K, Elswick SM, Grauberger JN, Amundson AC, Whitaker TJ, Remmes NB, Harless CA, Boughey JC, Nguyen MT, Park SS, Corbin KS, Mutter RW Tags: Radiother Oncol Source Type: research

Anti-epidermal growth factor receptor therapy in combination with chemoradiotherapy for the treatment of locally advanced anal canal carcinoma: Results of a phase I dose-escalation study with panitumumab (FFCD 0904).
CONCLUSIONS: The MTD is 5FU at 400 mg/m2/day, MMC at 10 mg/m2 and Pmab at 3 mg/kg. The effect of the MTD on tumour response is evaluated in the phase 2 study. PMID: 31185328 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 8, 2019 Category: Radiology Authors: Vendrely V, Lemanski C, Gnep K, Barbier E, Hajbi FE, Lledo G, Dahan L, Terrebonne E, Manfredi S, Mirabel X, Mammar V, Cowen D, Lepage C, Aparicio T, for FFCD investigators/Collaborators Tags: Radiother Oncol Source Type: research

PHASER: A platform for clinical translation of FLASH cancer radiotherapy.
Abstract Pluridirectional high-energy agile scanning electronic radiotherapy (PHASER) is next-generation medical linac technology for ultra-rapid highly conformal image-guided radiation, fast enough to "freeze" physiological motion, affording improved accuracy, precision, and potentially superior FLASH radiobiological therapeutic index. Designed for compactness, economy, and clinical efficiency, it is also intended to address barriers to global access to curative radiotherapy. PMID: 31178058 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for ...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 6, 2019 Category: Radiology Authors: Maxim PG, Tantawi SG, Loo BW Tags: Radiother Oncol Source Type: research

Early biochemical predictors of survival in intermediate and high-risk prostate cancer treated with radiation and androgen deprivation therapy.
Abstract BACKGROUND AND PURPOSE: To identify early biochemical predictors of survival in intermediate- and high-risk prostate cancer patients with a pre-treatment PSA
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 6, 2019 Category: Radiology Authors: Patel MA, Kollmeier M, McBride S, Gorovets D, Varghese M, Chan L, Knezevic A, Zhang Z, Zelefsky MJ Tags: Radiother Oncol Source Type: research

The prognostic role of 18F-fluorodeoxyglucose PET in head and neck cancer depends on HPV status.
Abstract BACKGROUND AND PURPOSE: Standardized uptake value (SUV) and related parameters derived from 2-deoxy-2-[18F]-fluoro-d-glucose (FDG) PET/CT prior to radiochemotherapy of head and neck cancer (HNC) were significantly associated with survival in a number of studies. The aim of this study was to validate these findings and to evaluate the prognostic role of PET parameters also including clinical factors and HPV status. MATERIALS AND METHODS: We reviewed 166 HNC cases with a radiotherapy planning FDG PET/CT scan. All patients received radiotherapy, 68-70 Gy with or without concomitant cisplatin. Primary ...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 6, 2019 Category: Radiology Authors: Moan JM, Amdal CD, Malinen E, Svestad JG, Bogsrud TV, Dale E Tags: Radiother Oncol Source Type: research

Radiotherapy for node-positive prostate cancer: 2019 Recommendations of the Australian and New Zealand Radiation Oncology Genito-Urinary group.
Abstract The management of node-positive prostate cancer is highly variable, with both locoregional and systemic treatment options available. With the increasing use of novel imaging techniques such as PSMA-PET and MRI, combined with the increasing use of surgery for high-risk prostate cancer, clinical and pathological regional nodal disease is being detected at a higher rate and at an earlier stage than previously. This creates a window for a potentially curative management approach. The role of radiotherapy including optimal radiation target volumes and dose, as well as the timing and duration of accompanying sy...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 6, 2019 Category: Radiology Authors: Lieng H, Kneebone A, Hayden AJ, Christie DRH, Davis BJ, Eade TN, Emmett L, Holt T, Hruby G, Pryor D, Sidhom M, Skala M, Yaxley J, Shakespeare TP Tags: Radiother Oncol Source Type: research

Practical effectiveness of re-irradiation with or without surgery for locoregional recurrence of rectal cancer: A meta-analysis and systematic review.
Abstract BACKGROUND AND PURPOSE: Re-irradiation might yield local control (LC) or palliation for locoregionally recurrent rectal cancer (LRRC), but iatrogenic complications are a possible hindrance. We aimed to evaluate the efficacy of re-irradiation to determine optimal treatment of LRRC. METHODS: We performed a systematic review of PubMed, MEDLINE, Cochrane Library, and Embase. RESULTS: A total of 17 studies involving 744 patients with LRRC were included; median OS ranging from 10 to 45 months (median: 24.5 months). Pooled 1-, 2-, and 3-year OS rates for all patients were 76.1%, 49.1%, and 38.3%, r...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 5, 2019 Category: Radiology Authors: Lee J, Kim CY, Koom WS, Rim CH Tags: Radiother Oncol Source Type: research

Postoperative adjuvant IMRT for patients with HCC and portal vein tumor thrombus: An open-label randomized controlled trial.
CONCLUSIONS: Postoperative IMRT significantly improved the overall survival outcomes in patients with HCC and PVTT after partial hepatectomy +/- thrombectomy. PMID: 31176205 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 5, 2019 Category: Radiology Authors: Sun J, Yang L, Shi J, Liu C, Zhang X, Chai Z, Lau WY, Meng Y, Cheng SQ Tags: Radiother Oncol Source Type: research

Pre-treatment serum bicarbonate predicts for primary tumor control after stereotactic body radiation therapy in patients with localized non-small cell lung cancer.
Abstract BACKGROUND: Tumor aggressiveness and hypoxia are linked to acidosis in the tumor microenvironment (TME). We hypothesized that low pre-treatment serum bicarbonate, potentially correlating with an acidic and hypoxic TME, predicts for poor outcomes after stereotactic body radiation therapy (SBRT) for non-small cell lung cancer (NSCLC). METHODS: We included patients with localized NSCLC treated to a biologically effective dose (BED) ≥ 100 Gy, with available pre-treatment bicarbonate values within 3 months of treatment. We used receiver operating characteristic analysis to determine the bicarbo...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 5, 2019 Category: Radiology Authors: Sebastian N, Wu T, Driscoll E, Willers H, Kelly S, Musunuru HB, Mo X, Tan Y, Bazan J, Haglund K, Xu-Welliver M, Baschnagel AM, Ju A, Keane F, Williams TM Tags: Radiother Oncol Source Type: research

Quantifying effects of radiotherapy-induced microvascular injury; review of established and emerging brain MRI techniques.
Abstract Microvascular changes are increasingly recognised not only as primary drivers of radiotherapy treatment response in brain tumours, but also as an important contributor to short- and long-term (cognitive) side effects arising from irradiation of otherwise healthy brain tissue. As overall survival of patients with brain tumours is increasing, monitoring long-term sequels of radiotherapy-induced microvascular changes in the context of their potential predictive power for outcome, such as cognitive disability, has become increasingly relevant. Ideally, radiotherapy-induced significant microvascular changes in...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 5, 2019 Category: Radiology Authors: Kłos J, van Laar PJ, Sinnige PF, Enting RH, Kramer MCA, van der Weide HL, van Buchem MA, Dierckx RAJO, Borra RJH, van der Hoorn A Tags: Radiother Oncol Source Type: research

Robot-assisted radical prostatectomy versus volumetric modulated arc therapy: Comparison of front-line therapies for localized prostate cancer.
Abstract BACKGROUND: Although radical prostatectomy and external beam radiotherapy are recognized as comparable treatment options for localized prostate cancer, robot-assisted radical prostatectomy (RARP) and volumetric modulated arc therapy (VMAT) as the leading respective techniques have yet to be compared. METHODS: We retrospectively analyzed 860 patients with cT1-4N0M0 prostate cancer who underwent RARP (n = 500) or VMAT (n = 360) between 2011 and 2016. Biochemical recurrence-free survival (bRFS; two consecutive prostate-specific antigen measurements ≥0.2 ng/ml for RARP and Phoenix definition...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 5, 2019 Category: Radiology Authors: Taguchi S, Shiraishi K, Fujimura T, Naito A, Kawai T, Nakagawa K, Abe O, Kume H, Fukuhara H Tags: Radiother Oncol Source Type: research

Dosimetric and preparation procedures for irradiating biological models with pulsed electron beam at ultra-high dose-rate.
CONCLUSION: We developed procedures to accurately irradiate biological models. Our method is based on validated absolute dosimeters and extends their use to routine FLASH irradiations. We reached an agreement of 3% between the delivered and prescribed dose and developed the requirements needed for workflows of preclinical and clinical studies. PMID: 31174897 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 4, 2019 Category: Radiology Authors: Jorge PG, Jaccard M, Petersson K, Gondré M, Durán MT, Desorgher L, Germond JF, Liger P, Vozenin MC, Bourhis J, Bochud F, Moeckli R, Bailat C Tags: Radiother Oncol Source Type: research

Clinical practice and outcomes of palliative radiation therapy in pediatric oncology patients: An international comparison of experiences from two distinct countries and health care systems.
CONCLUSION: Despite different practices, the clinical results using palliative RT for pediatric patients treated in two unique healthcare environments demonstrated it is an effective tool for pediatric oncology patients across systems. PMID: 31174104 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 4, 2019 Category: Radiology Authors: Rao AD, Figueiredo MLS, Yegya-Raman N, Sehgal S, Chen Q, Alcorn SR, Chen MJ, Ladra M, Villar R, Terezakis SA Tags: Radiother Oncol Source Type: research

Locally advanced hypopharyngeal and laryngeal cancer: Influence of HPV status.
CONCLUSIONS: These data suggest that HPV status may be a prognostic factor in patients with T4a LSCC. Further, it supports further investigation into the usefulness of HPV status as a selection factor for larynx preservation with CRT in these patients. PMID: 31174105 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 4, 2019 Category: Radiology Authors: Bates JE, Morris CG, Hitchcock KE, Dziegielewski PT, Mendenhall WM, Amdur RJ Tags: Radiother Oncol Source Type: research

Micro cone beam computed tomography for sensitive assessment of radiation-induced late lung toxicity in preclinical models.
CONCLUSION: µCBCT after right lung µIGRT enables the sensitive detection of effects inflicted by relative small dose increments or radio-sensitizers. Our preclinical model therefore facilitates the determination of lung damage exacerbation for the safety assessment of novel RT-drug combinations. PMID: 31146069 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 27, 2019 Category: Radiology Authors: van Berlo D, Khmelinskii A, Gasparini A, Salguero FJ, Floot B, de Wit N, van de Ven M, Song JY, Coppes RP, Verheij M, Sonke JJ, Vens C Tags: Radiother Oncol Source Type: research

Toward personalized dose-prescription in locally advanced non-small cell lung cancer: Validation of published normal tissue complication probability models.
Abstract PURPOSE: To identify published normal tissue complication probability (NTCP) models suitable for patient-specific dose-prescription in locally advanced non-small cell lung cancer (LA-NSCLC) through in-house validation. MATERIAL AND METHODS: From eight previously published candidate NTCP models (≥grade 2 acute esophagitis and radiation pneumonitis; AE2, RP2), patient-specific dose-responses were calculated using model variables and fractionation-corrected doses for 241 LA-NSCLC patients treated with chemo-IMRT to 50-80 Gy@1.8-2.0 Gy between 2004 and 2014 (AE2/RP2 rate: 50%/12%). A model was jud...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 27, 2019 Category: Radiology Authors: Thor M, Deasy J, Iyer A, Bendau E, Fontanella A, Apte A, Yorke E, Rimner A, Jackson A Tags: Radiother Oncol Source Type: research

Inclusion of heart substructures in the optimization process of volumetric modulated arc therapy techniques may reduce the risk of heart disease in Hodgkin's lymphoma patients.
This study aimed to reduce the risk of cardiovascular events through an optimization of the dose distribution on heart substructures in mediastinal HL patients with the adoption of different volumetric modulated arc therapy (VMAT) techniques, while maintaining the same risk of second cancer induction on lungs and breasts. MATERIALS AND METHODS: Thirty patients (15 males and 15 females, 15 bulky lesions) treated between 2012 and 2017 at our institution were selected. Disease extent was mediastinum plus neck (n = 10), mediastinum plus unilateral axilla (n = 10) and mediastinum alone (n = 10). Lungs, breasts,...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 27, 2019 Category: Radiology Authors: Levis M, Filippi AR, Fiandra C, De Luca V, Bartoncini S, Vella D, Ragona R, Ricardi U Tags: Radiother Oncol Source Type: research

REQUITE: A prospective multicentre cohort study of patients undergoing radiotherapy for breast, lung or prostate cancer.
CONCLUSION: The comprehensive centralised database and linked biobank is a valuable resource for the radiotherapy community for validating predictive models and biomarkers. PATIENT SUMMARY: Up to half of cancer patients undergo radiation therapy and irradiation of surrounding healthy tissue is unavoidable. Damage to healthy tissue can affect short- and long-term quality-of-life. Not all patients are equally sensitive to radiation "damage" but it is not possible at the moment to identify those who are. REQUITE was established with the aim of trying to understand more about how we could predict radiation sensi...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 27, 2019 Category: Radiology Authors: Seibold P, Webb A, Aguado-Barrera ME, Azria D, Bourgier C, Brengues M, Briers E, Bultijnck R, Calvo-Crespo P, Carballo A, Choudhury A, Cicchetti A, Claßen J, Delmastro E, Dunning AM, Elliott RM, Farcy-Jacquet MP, Gabriele P, Garibaldi E, Gómez-Caamaño Tags: Radiother Oncol Source Type: research

Benefits of deep learning for delineation of organs at risk in head and neck cancer.
Abstract PURPOSE/OBJECTIVE: Precise delineation of organs at risk (OARs) in head and neck cancer (HNC) is necessary for accurate radiotherapy. Although guidelines exist, significant interobserver variability (IOV) remains. The aim was to validate a 3D convolutional neural network (CNN) for semi-automated delineation of OARs with respect to delineation accuracy, efficiency and consistency compared to manual delineation. MATERIAL/METHODS: 16 OARs were manually delineated in 15 new HNC patients by two trained radiation oncologists (RO) independently, using international consensus guidelines. OARs were also autom...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 27, 2019 Category: Radiology Authors: van der Veen J, Willems S, Deschuymer S, Robben D, Crijns W, Maes F, Nuyts S Tags: Radiother Oncol Source Type: research

Multi-object tracking in MRI-guided radiotherapy using the tracking-learning-detection framework.
Abstract The application of the tracking-learning-detection (TLD) framework; a performant tracking algorithm for real-life objects in CCD video, was evaluated and successfully optimized for tracking anatomical structures in low-quality 2D cine-MRI acquired during MRI-guided radiotherapy. Sub-pixel tracking accuracy and>95% precision and recall was achieved despite significant deformations and periodical disappearance. PMID: 31136959 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 25, 2019 Category: Radiology Authors: Dhont J, Vandemeulebroucke J, Cusumano D, Boldrini L, Cellini F, Valentini V, Verellen D Tags: Radiother Oncol Source Type: research

Application of presurgical navigated transcranial magnetic stimulation motor mapping for adjuvant radiotherapy planning in patients with high-grade gliomas.
This study evaluates the implementation of nTMS motor mapping in RT planning in patients harboring motor-eloquent HGGs with the aim of reducing dose applications to the motor cortex. METHODS: nTMS motor maps of 30 patients diagnosed with motor-eloquent HGGs were fused with RT planning imaging and volumetric modulated RT plans were optimized using nTMS motor maps as an organ at risk (OAR). Doses to nTMS motor maps were evaluated using dose-volume histogram (DVH) parameters. RESULTS: Mean dose (Dmean) to the nTMS motor maps was 42.3 Gy (3.7-61.1 Gy) and was significantly reduced by 14.3% to 37.0 Gy (3.6-55.8 Gy, p 
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 25, 2019 Category: Radiology Authors: Diehl CD, Schwendner MJ, Sollmann N, Oechsner M, Meyer B, Combs SE, Krieg SM Tags: Radiother Oncol Source Type: research

Systematic review and meta-analysis of small bowel dose-volume and acute toxicity in conventionally-fractionated rectal cancer radiotherapy.
Abstract INTRODUCTION: The limited radiation tolerance of the small-bowel causes toxicity for patients receiving conventionally-fractionated radiotherapy for rectal cancer. Safe radiotherapy dose-escalation will require a better understanding of such toxicity. We conducted a systematic review and meta-analysis using published datasets of small bowel dose-volume and outcomes to analyse the relationship with acute toxicity. MATERIALS AND METHODS: SCOPUS, EMBASE & MEDLINE were searched to identify twelve publications reporting small-bowel dose-volumes and toxicity data or analysis. Where suitable data were a...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 25, 2019 Category: Radiology Authors: Holyoake DLP, Partridge M, Hawkins MA Tags: Radiother Oncol Source Type: research

A hepatocyte growth factor/MET-induced antiapoptotic pathway protects against radiation-induced salivary gland dysfunction.
CONCLUSIONS: These results suggest that HGF is a key effector of radioprotection and that HGF-MET-PI3K-AKT axis is involved in protecting the salivary glands from radiation-induced apoptosis. PMID: 31136962 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 25, 2019 Category: Radiology Authors: Yoon YJ, Shin HS, Lim JY Tags: Radiother Oncol Source Type: research

Hyperthermia with radiotherapy reduces tumour alpha/beta: Insights from trials of thermoradiotherapy vs radiotherapy alone.
This study estimates the clinical α/βHTRT values from clinical trials of thermoradiotherapy (HTRT) vs radiotherapy (RT) in recurrent breast (RcBC), head and neck (III/IV) (LAHNC) and cervix cancers (IIB-IVA) (LACC). METHODS: Three recently published meta-analyses for HTRT vs RT in RcBC, LAHNC and LACC were evaluated for complete response (CR). Studies with specified RT dose (D), dose/fraction (d) and corresponding CRs were selected. Tumour biological effective dose (BED) for each study with RT (BEDRT) was computed assuming an α/βRT of 10 Gy. As outcomes were favourable with HTRT, thermoradiobio...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 24, 2019 Category: Radiology Authors: Datta NR, Bodis S Tags: Radiother Oncol Source Type: research

EGCG, a green tea polyphenol, as one more weapon in the arsenal to fight radiation esophagitis?
PMID: 31133342 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 24, 2019 Category: Radiology Authors: Kępka L, Rychter A Tags: Radiother Oncol Source Type: research

Imaging of regional ventilation: Is CT ventilation imaging the answer? A systematic review of the validation data.
Abstract Computed Tomography Ventilation Imaging (CTVI) is an experimental imaging modality that derives regional lung function information from non-contrast respiratory-correlated CT datasets. Despite CTVI being extensively studied in cross-modality imaging comparisons, there is a lack of consensus on the state of its clinical validation in humans. This systematic review evaluates the CTVI clinical validation studies to date, highlights their common strengths and weaknesses and makes recommendations. We performed a PUBMED and EMBASE search of all English language papers on CTVI between 2000 and 2018. The results ...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 23, 2019 Category: Radiology Authors: Hegi-Johnson F, de Ruysscher D, Keall P, Hendriks L, Vinogradskiy Y, Yamamoto T, Tahir B, Kipritidis J Tags: Radiother Oncol Source Type: research

Big data analysis of associations between patient reported outcomes, observer reported toxicities, and overall quality of life in head and neck cancer patients treated with radiation therapy.
CONCLUSIONS: PRO associations identified activity, lifestyle and fatigue as items for strong consideration for inclusion in questionnaires in the clinic, and suggest that outcome information can be captured in fewer items than the 27 in this study. The ability of clinicians to assess patient toxicities is highest with more severe toxicities, underscoring the need for PRO collection in patient visits to understand and address patient symptoms. PMID: 31128357 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 22, 2019 Category: Radiology Authors: Wilkie JR, Mierzwa ML, Yao J, Eisbruch A, Feng M, Weyburne G, Chen X, Holevinski L, Mayo CS Tags: Radiother Oncol Source Type: research

Boron neutron capture therapy for locally recurrent head and neck squamous cell carcinoma: An analysis of dose response and survival.
CONCLUSIONS: Most patients responded to BNCT. A high minimum tumor dose from BNCT was predictive for response and survival. PMID: 31108276 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 17, 2019 Category: Radiology Authors: Koivunoro H, Kankaanranta L, Seppälä T, Haapaniemi A, Mäkitie A, Joensuu H Tags: Radiother Oncol Source Type: research

ESTRO consensus guideline for target volume delineation in the setting of postmastectomy radiation therapy after implant-based immediate reconstruction for early stage breast cancer.
tt Nystrom P, Senkus E, Skyttä T, Tvedskov TF, Verhoeven K, Poortmans P Abstract Immediate breast reconstruction (IBR) rates after mastectomy are increasing. Postmastectomy radiation therapy (PMRT) contouring guidelines for target volumes in the setting of IBR are lacking. Therefore, many patients who have had IBR receive PMRT to target volumes similar to conventional simulator-based whole breast irradiation. The aim of this paper is to describe delineation guidelines for PMRT after implant-based IBR based on a thorough understanding of the surgical procedures, disease stage, patterns of recurrence and radiat...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 17, 2019 Category: Radiology Authors: Kaidar-Person O, Vrou Offersen B, Hol S, Arenas M, Aristei C, Bourgier C, Joao Cardoso M, Chua B, Coles CE, Engberg Damsgaard T, Gabrys D, Jagsi R, Jimenez R, Kirby AM, Kirkove C, Kirova Y, Kouloulias V, Marinko T, Meattini I, Mjaaland I, Nader Marta G, W Tags: Radiother Oncol Source Type: research

Tumor localization accuracy for high-precision radiotherapy during active breath-hold.
CONCLUSIONS: This investigation shows that because variations in the breath-hold volume may cause target dislocation, patient-specific breath-hold setting is required to improve tumor localization accuracy. PMID: 31103912 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 16, 2019 Category: Radiology Authors: Lee S, Zheng Y, Podder T, Biswas T, Verma V, Goss M, Colonias A, Fuhrer R, Zhai Y, Parda D, Sohn J Tags: Radiother Oncol Source Type: research

Clinical features and survival outcomes between ascending and descending types of nasopharyngeal carcinoma in the intensity-modulated radiotherapy era: A big-data intelligence platform-based analysis.
Abstract PURPOSE: To compare clinical features and survival outcomes in patients with ascending type (type A) and descending type (type D) nasopharyngeal carcinoma (NPC) in the intensity-modulated radiotherapy (IMRT) era. MATERIALS AND METHODS: A total of 5194 patients with type A and type D NPC treated at Sun Yat-sen University Cancer Center were randomly selected. Tumors that were mainly advanced local disease (T3-4 stage) with early stage cervical lymph node involvement (N0-1 stage) were determined as type A, while tumors with advanced lymph node disease (N2-3 stage) but early stage local invasion (T1-2 st...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 15, 2019 Category: Radiology Authors: Yao JJ, Qi ZY, Liu ZG, Jiang GM, Xu XW, Chen SY, Zhu FT, Zhang WJ, Lawrence WR, Ma J, Zhou GQ, Sun Y Tags: Radiother Oncol Source Type: research

The first prototype of spot-scanning proton arc treatment delivery.
CONCLUSION: The first prototype of dynamic proton arc delivery on a clinical proton therapy system was successfully performed. The measurements and simulations demonstrated the feasibility of SPArc treatment within the clinical requirements. PMID: 31100606 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 14, 2019 Category: Radiology Authors: Li X, Liu G, Janssens G, De Wilde O, Bossier V, Lerot X, Pouppez A, Yan D, Stevens C, Kabolizadeh P, Ding X Tags: Radiother Oncol Source Type: research

An evaluation of the mid-ventilation method for the planning of stereotactic lung plans.
CONCLUSION: Our results confirm that a mid-V approach can be used to reduce the PTV size, with no loss of tumour coverage. We propose the use of a simplified margin formula equal to the margin ignoring breathing plus 0.15 of the range of motion. PMID: 31085390 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 11, 2019 Category: Radiology Authors: Thomas SJ, Evans BJ, Harihar L, Chantler HJ, Martin AGR, Harden SV Tags: Radiother Oncol Source Type: research

The impact of sarcopenia on tolerance of radiation and outcome in patients with head and neck cancer receiving chemoradiation.
Abstract BACKGROUND AND PURPOSE: Sarcopenia is a predictor of poor prognosis in cancer patients. One potential mechanism for worse outcomes in sarcopenic patients is worse tolerance to treatment; this has not been investigated with regard to radiation treatment. We reviewed our institutional experience of head and neck cancer patients receiving concurrent chemoradiation and assessed outcomes with respect to sarcopenia. MATERIALS AND METHODS: Patients treated between 2012 and 2016 were reviewed. Sarcopenia was assessed from radiation planning computed tomography (CT) scans using muscles at the C3 vertebral bod...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 11, 2019 Category: Radiology Authors: Ganju RG, Morse R, Hoover A, TenNapel M, Lominska CE Tags: Radiother Oncol Source Type: research

In vitro biological response of cancer and normal tissue cells to proton irradiation not affected by an added magnetic field.
Abstract To optimize beam delivery and conformality of proton therapy, MRI integration has been proposed. Therefore, we investigated if proton irradiation in a magnetic field would change biological responses. Our data in cancer cell lines and stem cell-derived organoid models suggest that a magnetic field does not modify the biological response. PMID: 31085392 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 11, 2019 Category: Radiology Authors: Nagle PW, van Goethem MJ, Kempers M, Kiewit H, Knopf A, Langendijk JA, Brandenburg S, van Luijk P, Coppes RP Tags: Radiother Oncol Source Type: research

Evaluating radiotherapy treatment delay using Failure Mode and Effects Analysis (FMEA).
CONCLUSION: The FMEA enabled identification of the factors that caused delay in the pre-treatment process of radiation therapy. "CT-Sim" and "treatment planning" stages had more FMs with high RPN values which have higher priority for future improvement. Two new factors, SE and EE, were introduced and appeared to be valuable in evaluating the impact of FMs on radiation oncology department or hospital in general. PMID: 31082631 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 10, 2019 Category: Radiology Authors: Xu Z, Lee S, Albani D, Dobbins D, Ellis RJ, Biswas T, Machtay M, Podder TK Tags: Radiother Oncol Source Type: research

Long-term outcomes and late adverse effects of a prospective study on proton radiotherapy for patients with low-grade glioma.
CONCLUSIONS: The majority of patients with LGG who received proton therapy retained stable cognitive and neuroendocrine function. The IDH1-R132H mutation was present in the majority, while 1p/19q loss was present in a minority. A subset of patients developed neuroendocrine deficiencies and was more common in those with higher dose to the HPA. PMID: 31082632 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 10, 2019 Category: Radiology Authors: Tabrizi S, Yeap BY, Sherman JC, Nachtigall LB, Colvin MK, Dworkin M, Fullerton BC, Daartz J, Royce TJ, Oh KS, Batchelor TT, Curry WT, Loeffler JS, Shih HA Tags: Radiother Oncol Source Type: research

Radiation-induced and neurofibromatosis-associated malignant peripheral nerve sheath tumors (MPNST) have worse outcomes than sporadic MPNST.
CONCLUSIONS: Both radiation-induced and neurofibromatosis-associated MPNSTs have poorer prognosis than sporadic MPNSTs. Complete resection of the tumor is a significant prognostic factor for MPNST. The addition of radiotherapy after surgery should be considered especially when the surgical margins are positive. PMID: 31078939 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 9, 2019 Category: Radiology Authors: Miao R, Wang H, Jacobson A, Lietz AP, Choy E, Raskin KA, Schwab JH, Deshpande V, Nielsen GP, DeLaney TF, Cote GM, Hornicek FJ, Chen YE Tags: Radiother Oncol Source Type: research

Influence of tumour laterality on patient survival in non-small cell lung cancer after radiotherapy.
Abstract BACKGROUND: Lung cancer survival after radiotherapy remains poor and greater knowledge of normal tissue risk factors is needed to further optimise treatments. In this work, we investigate tumour laterality in a large cohort of patients treated with curative-intent radiotherapy, including the effect of dose on the right and left lungs. METHODS: 1101 NSCLC patients were included in the analysis, treated with 55 Gy in 20 fractions. Tumour laterality was determined by comparing the centre of mass of the tumour volume with the centre of mass of the lung. Right and left lungs were segmented from the whol...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 9, 2019 Category: Radiology Authors: McWilliam A, Vasquez Osorio E, Faivre-Finn C, van Herk M Tags: Radiother Oncol Source Type: research