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Monitoring early changes in rectal tumor morphology and volume during 5  weeks of preoperative chemoradiotherapy - An evaluation with sequential MRIs.
CONCLUSION: Results of this exploratory pilot study suggest that changes in rectal tumor morphology (fibrosis) and volume can already be observed early during radiation, both when measured quantitatively and when assessed visually. These changes appear to be indicative of the final treatment outcome. PMID: 29343409 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 15, 2018 Category: Radiology Authors: Lambregts DMJ, Yassien AB, Lahaye MJ, Betgen A, Maas M, Beets GL, van der Heide UA, van Triest B, Beets-Tan RGH Tags: Radiother Oncol Source Type: research

Response to 'Perilesional edema in brain cancer: Independent prognosticator or epiphenomenon of biomolecular signature?'
PMID: 29343408 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 14, 2018 Category: Radiology Authors: Liang HT, Tseng WI Tags: Radiother Oncol Source Type: research

Standard whole prostate gland radiotherapy with and without lesion boost in prostate cancer: Toxicity in the FLAME randomized controlled trial.
CONCLUSIONS: In intermediate- and high-risk prostate cancer patients, focal dose escalation integrated with standard EBRT did not result in an increase in GU and GI toxicity when compared to the standard treatment up to two years after treatment. This suggests that the described focal dose escalation technique is safe and feasible. PMID: 29336835 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 11, 2018 Category: Radiology Authors: Monninkhof EM, van Loon JWL, van Vulpen M, Kerkmeijer LGW, Pos FJ, Haustermans K, van den Bergh L, Isebaert S, McColl GM, Jan Smeenk R, Noteboom J, Walraven I, Peeters PHM, van der Heide UA Tags: Radiother Oncol Source Type: research

Perilesional edema in brain cancer: Independent prognosticator or epiphenomenon of biomolecular signature?
PMID: 29331541 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 10, 2018 Category: Radiology Authors: Nardone V, Vinciguerra C, Federico A, Cerase A, Pirtoli L, Tini P Tags: Radiother Oncol Source Type: research

Concurrent chemoradiotherapy alone is feasible for esophageal squamous cell carcinoma patients not suitable for surgery.
PMID: 29331542 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 10, 2018 Category: Radiology Authors: Chen Y, Wang J Tags: Radiother Oncol Source Type: research

Consolidation chemotherapy after definite concurrent chemoradiation in patients with non-operable esophageal cancer: Is it useful?
PMID: 29331543 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 10, 2018 Category: Radiology Authors: Adenis A, Castan F, Conroy T Tags: Radiother Oncol Source Type: research

Letter to the Editor on Nevens et al.
PMID: 29317113 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 6, 2018 Category: Radiology Authors: Elicin O, Giger R Tags: Radiother Oncol Source Type: research

Proton beam therapy for skull base chordomas in 106 patients: A dose adaptive radiation protocol.
CONCLUSIONS: This study suggests that the probability of LC of skull base chordomas depends on postoperative GTV. The dose adaptive protocol achieves acceptable local control. Future studies should investigate whether further dose escalation to doses in excess of 74 Gy(RBE) would achieve better results. PMID: 29310903 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 6, 2018 Category: Radiology Authors: Fung V, Calugaru V, Bolle S, Mammar H, Alapetite C, Maingon P, De Marzi L, Froelich S, Habrand JL, Dendale R, Noël G, Feuvret L Tags: Radiother Oncol Source Type: research

Upfront vs. no upfront neck dissection in primary head and neck cancer radio(chemo)therapy: Reply to Elicin et al.
PMID: 29307729 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 4, 2018 Category: Radiology Authors: Nevens D, Duprez F, Bonte K, Deron P, Huvenne W, Laenen A, De Neve W, Nuyts S Tags: Radiother Oncol Source Type: research

Short- and long-term risks of cardiovascular disease following radiotherapy in rectal cancer in four randomized controlled trials and a population-based register.
DISCUSSION: Preoperative radiotherapy did not affect rectal cancer patients' risk of CVD overall. Although an excess risk of short-term venous thromboembolism was noted, the small increase in absolute numbers does not call for general changes in routine prophylactic treatment, but might do so for patients already at high risk of venous thromboembolism. PMID: 29306497 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 3, 2018 Category: Radiology Authors: Chen L, Eloranta S, Martling A, Glimelius I, Neovius M, Glimelius B, Smedby KE Tags: Radiother Oncol Source Type: research

Concurrent chemoradiotherapy for bladder cancer: Practice patterns and outcomes in the general population.
We describe uptake of CRT and comparative effectiveness in routine practice. METHODS: Electronic treatment records were linked to the population-based Ontario Cancer Registry to identify all patients with bladder cancer treated with curative-intent RT in 1999-2013. Modified Poisson regression was used to analyze factors associated with use of CRT. Cox model and propensity score analyses were used to explore factors associated with cancer-specific (CSS) and overall survival (OS). RESULTS: 1192 patients underwent RT during 1999-2013; median age was 79. Use of CRT increased over time: 36% (124/341) in 1999-2003, 38%...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 3, 2018 Category: Radiology Authors: Ghate K, Brennan K, Karim S, Siemens DR, Mackillop WJ, Booth CM Tags: Radiother Oncol Source Type: research

Comparison of detection methods for HPV status as a prognostic marker for loco-regional control after radiochemotherapy in patients with HNSCC.
Baretton GB, Buchholz F, Krause M, Belka C, Baumann M, DKTK-ROG Abstract OBJECTIVE: To compare six HPV detection methods in pre-treatment FFPE tumour samples from patients with locally advanced head and neck squamous cell carcinoma (HNSCC) who received postoperative (N = 175) or primary (N = 90) radiochemotherapy. MATERIALS AND METHODS: HPV analyses included detection of (i) HPV16 E6/E7 RNA, (ii) HPV16 DNA (PCR-based arrays, A-PCR), (iii) HPV DNA (GP5+/GP6+ qPCR, (GP-PCR)), (iv) p16 (immunohistochemistry, p16 IHC), (v) combining p16 IHC and the A-PCR result and (vi) combining p16 IHC and the GP-PCR r...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 30, 2017 Category: Radiology Authors: Linge A, Schötz U, Löck S, Lohaus F, Neubeck CV, Gudziol V, Nowak A, Tinhofer I, Budach V, Sak A, Stuschke M, Balermpas P, Rödel C, Bunea H, Grosu AL, Abdollahi A, Debus J, Ganswindt U, Lauber K, Pigorsch S, Combs SE, Mönnich D, Zips D, Baretton GB, B Tags: Radiother Oncol Source Type: research

Hypofractionated radiation therapy (HFRT) versus conventional fractionated radiation therapy (CRT) for newly diagnosed glioblastoma patients. A propensity score matched analysis.
CONCLUSIONS: A short course of radiation therapy would seem comparable to CRT in terms of outcome and less burdensome for these poor prognosis patients. PMID: 29291951 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 29, 2017 Category: Radiology Authors: Navarria P, Pessina F, Franzese C, Tomatis S, Perrino M, Cozzi L, Simonelli M, Bello L, Clerici E, Riva M, Santoro A, Scorsetti M Tags: Radiother Oncol Source Type: research

CT ventilation imaging derived from breath hold CT exhibits good regional accuracy with Galligas PET.
CONCLUSIONS: High quality CT imaging is a key requirement for accurate CT ventilation imaging. The use of exhale/inhale BHCT can improve the accuracy of CTVI for human subjects. PMID: 29290405 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 28, 2017 Category: Radiology Authors: Eslick EM, Kipritidis J, Gradinscak D, Stevens MJ, Bailey DL, Harris B, Booth JT, Keall PJ Tags: Radiother Oncol Source Type: research

Response to Stephane Renaud et al.
PMID: 29287737 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 26, 2017 Category: Radiology Authors: Yang WC, Shih JY, Ho CC, Hsu FM Tags: Radiother Oncol Source Type: research

MRI evaluation of sacral chordoma treated with carbon ion radiotherapy alone.
Abstract BACKGROUND AND PURPOSE: To compare RECIST 1.1 with volume modifications in patients with sacral chordoma not suitable for surgery treated with carbon ions radiotherapy (CIRT) alone. To evaluate patients pain before and after CIRT. To detect if baseline Apparent Diffusion Coefficient values (ADC) from Diffusion Weighted sequences could predict response to treatment. MATERIAL AND METHODS: Patients included had one cycle of CIRT and underwent MRI before and after treatment. For each MRI, lesion maximum diameter and volume were obtained, and ADC values were analyzed within the whole lesion volume. Patien...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 23, 2017 Category: Radiology Authors: Preda L, Stoppa D, Fiore MR, Fontana G, Camisa S, Sacchi R, Ghitti M, Viselner G, Fossati P, Valvo F, Vitolo V, Bonora M, Iannalfi A, Vischioni B, Vai A, Mastella E, Baroni G, Orecchia R Tags: Radiother Oncol Source Type: research

Phase I trial of stereotactic MR-guided online adaptive radiation therapy (SMART) for the treatment of oligometastatic or unresectable primary malignancies of the abdomen.
Abstract PURPOSE/OBJECTIVES: SBRT is used to treat oligometastatic or unresectable primary abdominal malignancies, although ablative dose delivery is limited by proximity of organs-at-risk (OAR). Stereotactic, magnetic resonance (MR)-guided online-adaptive radiotherapy (SMART) may improve SBRT's therapeutic ratio. This prospective Phase I trial assessed feasibility and potential advantages of SMART to treat abdominal malignancies. MATERIALS/METHODS: Twenty patients with oligometastatic or unresectable primary liver (n = 10) and non-liver (n = 10) abdominal malignancies underwent SMART. Initial plans p...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 22, 2017 Category: Radiology Authors: Henke L, Kashani R, Robinson C, Curcuru A, DeWees T, Bradley J, Green O, Michalski J, Mutic S, Parikh P, Olsen J Tags: Radiother Oncol Source Type: research

Treatment of advanced nasopharyngeal cancer using low- or high-dose concurrent chemoradiotherapy with intensity-modulated radiotherapy: A propensity score-matched, nationwide, population-based cohort study.
CONCLUSION: LD-CCRT or HD-CCRT with IMRT can be a standard treatment that can prolong the survival of patients with advanced NPC. PMID: 29277447 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 22, 2017 Category: Radiology Authors: Chen TM, Lin KC, Yuan KS, Chang CL, Chow JM, Wu SY Tags: Radiother Oncol Source Type: research

Predicting hypoxia status using a combination of contrast-enhanced computed tomography and [18F]-Fluorodeoxyglucose positron emission tomography radiomics features.
CONCLUSION: A radiomics signature built from 18F-FDG PET and contrast-enhanced CT features correlates with 18F-FMISO TBRmax in head and neck cancer patients, providing significantly better performance with respect to models based on 18F-FDG PET only. Such a biomarker could potentially be useful to personalize head and neck cancer treatment at centers for which dedicated hypoxia imaging PET radiotracers are unavailable. PMID: 29273260 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 19, 2017 Category: Radiology Authors: Crispin-Ortuzar M, Apte A, Grkovski M, Oh JH, Lee NY, Schöder H, Humm JL, Deasy JO Tags: Radiother Oncol Source Type: research

Genotype-driven phase I study of weekly irinotecan in combination with capecitabine-based neoadjuvant chemoradiation for locally advanced rectal cancer.
CONCLUSION: A higher dose of weekly irinotecan in combination with capecitabine-based CRT is feasible under the guidance of the UGT1A1∗28 genotype. Further clinical trials at these dose levels are warranted. PMID: 29273261 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 19, 2017 Category: Radiology Authors: Zhu J, Li X, Shen Y, Guan Y, Gu W, Lian P, Sheng W, Cai S, Zhang Z Tags: Radiother Oncol Source Type: research

Long-term quality of life in inoperable non-small cell lung cancer patients treated with conventionally fractionated compared to hyperfractionated accelerated radiotherapy - Results of the randomized CHARTWEL trial.
CONCLUSIONS: Over three years, QoL was similar or more favorable under CHARTWEL compared to CF. Modeling QoL together with disease states provided additional insight into treatment comparisons. PMID: 29273262 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 19, 2017 Category: Radiology Authors: Hechtner M, Krause M, König J, Appold S, Hornemann B, Singer S, Baumann M Tags: Radiother Oncol Source Type: research

ESTRO ACROP: Technology for precision small animal radiotherapy research: Optimal use and challenges.
This report discusses the combination of precision irradiation systems, small animal imaging (CT, MRI, PET, SPECT, bioluminescence) systems, image registration, treatment planning, and data processing. It also provides guidelines for reporting on studies. PMID: 29269093 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 18, 2017 Category: Radiology Authors: Verhaegen F, Dubois L, Gianolini S, Hill MA, Karger CP, Lauber K, Prise KM, Sarrut D, Thorwarth D, Vanhove C, Vojnovic B, Weersink R, Wilkens JJ, Georg D Tags: Radiother Oncol Source Type: research

Prospect of robotic assistance for fully automated brachytherapy seed placement into skull base: Experimental validation in phantom and cadaver.
Abstract BACKGROUND AND PURPOSE: To investigate the feasibility and accuracy of robot-assisted brachytherapy for skull base tumours. MATERIAL AND METHODS: A custom robot system was tested on both phantom and cadaveric specimen. Cone beam CT (CBCT) images were transferred to the graphical user interface (GUI) for planning trajectories and the data were sent to the robot control unit. Following registration, the puncture needle was inserted into the target by the robot under navigation guidance, and seeds were implanted. Placement error was instantly displayed on the GUI; the result was verified after postopera...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 18, 2017 Category: Radiology Authors: Zhu JH, Wang J, Wang YG, Li M, Liu XJ, Guo CB Tags: Radiother Oncol Source Type: research

Systematic intrafraction shifts of mediastinal lymph node targets between setup imaging and radiation treatment delivery in lung cancer patients.
CONCLUSIONS: Systematic cranial and posterior intrafraction baseline shifts between CBCT and treatment delivery were observed for mediastinal LN targets. Intrafraction motion amplitudes were stable. PMID: 29258694 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 16, 2017 Category: Radiology Authors: Schmidt ML, Hoffmann L, Møller DS, Knap MM, Rasmussen TR, Folkersen BH, Poulsen PR Tags: Radiother Oncol Source Type: research

Nomogram to predict the benefit of additional induction chemotherapy to concurrent chemoradiotherapy in locoregionally advanced nasopharyngeal carcinoma: Analysis of a multicenter, phase III randomized trial.
CONCLUSION: We developed a convenient nomogram to estimate the benefit of IC for individual patients with LANPC. This tool can serve as a catalyst of individual treatment discussions and facilitator of informed decision-making. PMID: 29258695 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 16, 2017 Category: Radiology Authors: Zhang Y, Li WF, Liu X, Chen L, Sun R, Sun Y, Liu Q, Ma J Tags: Radiother Oncol Source Type: research

Comment on "Epidermal growth factor receptor mutation predicts favorable outcomes in non-small cell lung cancer patients with brain metastases treated with stereotactic radiosurgery", by Yang WC et al.
Comment on "Epidermal growth factor receptor mutation predicts favorable outcomes in non-small cell lung cancer patients with brain metastases treated with stereotactic radiosurgery", by Yang WC et al. Radiother Oncol. 2017 Dec 15;: Authors: Renaud S, Seitlinger J, Truntzer P, Noel G, Massard G PMID: 29254842 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 15, 2017 Category: Radiology Authors: Renaud S, Seitlinger J, Truntzer P, Noel G, Massard G Tags: Radiother Oncol Source Type: research

Severe lymphopenia during neoadjuvant chemoradiation for esophageal cancer: A propensity matched analysis of the relative risk of proton versus photon-based radiation therapy.
Abstract BACKGROUND AND PURPOSE: Circulating lymphocytes are exquisitely sensitive to radiation exposure, even to low scattered doses which can vary drastically between radiation modalities. We compared the relative risk of radiation-induced lymphopenia between intensity modulated radiation therapy (IMRT) or proton beam therapy (PBT) in esophageal cancer (EC) patients undergoing neoadjuvant chemoradiation therapy (nCRT). MATERIAL AND METHODS: EC patients treated with IMRT and PBT were propensity matched based on key clinical variables. Treatment-associated lymphopenia was graded using CTCAE v.4.0. Using match...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 13, 2017 Category: Radiology Authors: Shiraishi Y, Fang P, Xu C, Song J, Krishnan S, Koay EJ, Mehran RJ, Hofstetter WL, Blum-Murphy M, Ajani JA, Komaki R, Minsky B, Mohan R, Hsu CC, Hobbs BP, Lin SH Tags: Radiother Oncol Source Type: research

Local recurrences after curative IMRT for HNSCC: Effect of different GTV to high-dose CTV margins.
CONCLUSIONS: No relation was found between the recurrences' distributions as function of the margins used at three centers. In multivariate analysis, local control was not influenced by the centers. PMID: 29248171 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 13, 2017 Category: Radiology Authors: Zukauskaite R, Hansen CR, Grau C, Samsøe E, Johansen J, Petersen JBB, Andersen E, Brink C, Overgaard J, Eriksen JG Tags: Radiother Oncol Source Type: research

Serial 4DCT/4DPET imaging to predict and monitor response for locally-advanced non-small cell lung cancer chemo-radiotherapy.
Abstract BACKGROUND AND PURPOSE: A FDG-PET/CT image feature with optimal prognostic potential for locally-advanced non-small cell lung cancer (LA-NSCLC) patients has yet to be identified, and neither has the optimal time for FDG-PET/CT response assessment; furthermore, nodal features have been largely ignored in the literature. We propose to identify image features or imaging time point with maximal prognostic power. MATERIALS AND METHODS: Consecutive consenting patients with LA-NSCLC receiving curative intent CRT were enrolled. 4DPET/4DCT scans were acquired 0, 2, 4, and 7 weeks during IMRT treatment. Elev...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 12, 2017 Category: Radiology Authors: Bissonnette JP, Yap ML, Clarke K, Shessel A, Higgins J, Vines D, Atenafu EG, Becker N, Leavens C, Bezjak A, Jaffray DA, Sun A Tags: Radiother Oncol Source Type: research

Exposure of the lungs in breast cancer radiotherapy: A systematic review of lung doses published 2010-2015.
We report a systematic review of lung radiation doses from breast cancer radiotherapy. METHODS AND MATERIALS: Studies describing breast cancer radiotherapy regimens published during 2010-2015 and reporting lung dose were included. Doses were compared between different countries, anatomical regions irradiated, techniques and use of breathing adaptation. RESULTS: 471 regimens from 32 countries were identified. The average mean ipsilateral lung dose (MLDipsi) was 9.0 Gy. MLDipsi for supine radiotherapy with no breathing adaption was 8.4 Gy for whole breast/chest wall (WB/CW) radiotherapy, 11.2 Gy when the axil...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 12, 2017 Category: Radiology Authors: Aznar MC, Duane FK, Darby SC, Wang Z, Taylor CW Tags: Radiother Oncol Source Type: research

Comparison of radiation therapy modalities for hepatocellular carcinoma with portal vein thrombosis: A meta-analysis and systematic review.
CONCLUSIONS: OS did not differ among the modalities, although the response rates vary among modalities. PMID: 29233562 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 9, 2017 Category: Radiology Authors: Rim CH, Kim CY, Yang DS, Yoon WS Tags: Radiother Oncol Source Type: research

The population benefit of evidence-based radiotherapy: 5-Year local control and overall survival benefits.
Abstract BACKGROUND: To describe the population benefit of radiotherapy in a high-income setting if evidence-based guidelines were routinely followed. METHODS: Australian decision tree models were utilized. Radiotherapy alone (RT) benefit was defined as the absolute proportional benefit of radiotherapy compared with no treatment for radical indications, and of radiotherapy over surgery alone for adjuvant indications. Chemoradiotherapy (CRT) benefit was the absolute incremental benefit of concurrent chemoradiotherapy over RT. Five-year local control (LC) and overall survival (OS) benefits were measured. Citati...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 8, 2017 Category: Radiology Authors: Hanna TP, Shafiq J, Delaney GP, Vinod SK, Thompson SR, Barton MB Tags: Radiother Oncol Source Type: research

Patient reported dry mouth: Instrument comparison and model performance for correlation with quality of life in head and neck cancer survivors.
Cardoso R, Chambers MS, Sturgis EM, Mendoza TR, Lu C, Mohamed ASR, Fuller CD, Gunn GB Abstract PURPOSE: To identify a clinically meaningful cut-point for the single item dry mouth question of the MD Anderson Symptom Inventory-Head and Neck module (MDASI-HN). METHODS: Head and neck cancer survivors who had received radiation therapy (RT) completed the MDASI-HN, the University of Michigan Hospital Xerostomia Questionnaire (XQ), and the health visual analog scale (VAS) of the EuroQol Five Dimension Questionnaire (EQ-5D). The Bayesian information criteria (BIC) were used to test the prediction power of each tool ...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 8, 2017 Category: Radiology Authors: MD Anderson Head and Neck Cancer Symptom Working Group, Kamal M, Rosenthal DI, Volpe S, Goepfert RP, Garden AS, Hutcheson KA, Al Feghali KA, Meheissen MAM, Eraj SA, Dursteler AE, Williams B, Smith JB, Aymard JM, Berends J, White AL, Frank SJ, Morrison WH, Tags: Radiother Oncol Source Type: research

A method to combine target volume data from 3D and 4D planned thoracic radiotherapy patient cohorts for machine learning applications.
CONCLUSIONS: Accurate synthesis of GTV size from the iGTV permits the combination of lung cancer patient cohorts, facilitating machine learning applications in thoracic radiotherapy. PMID: 29223683 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 6, 2017 Category: Radiology Authors: Johnson C, Price G, Khalifa J, Faivre-Finn C, Dekker A, Moore C, van Herk M Tags: Radiother Oncol Source Type: research

Benefit of using motion compensated reconstructions for reducing inter-observer and intra-observer contouring variation for organs at risk in lung cancer patients.
CONCLUSIONS: This work shows that there is benefit in using motion compensated reconstructions for reducing both inter-observer and intra-observer contouring variations for organs at risk in lung cancer patients. PMID: 29221648 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 5, 2017 Category: Radiology Authors: McWilliam A, Lee L, Harris M, Sheikh H, Pemberton L, Faivre-Finn C, van Herk M Tags: Radiother Oncol Source Type: research

Phase I-III development of the EORTC QLQ-ANL27, a health-related quality of life questionnaire for anal cancer.
CONCLUSION: We have developed a 27 item questionnaire to supplement the EORTC QLQ-C30, for use with patients treated for anal cancer. This has been pilot tested and is now available upon request for use in clinical trials as well as clinical practice in 8 languages (http://groups.eortc.be/qol/). PMID: 29217122 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 4, 2017 Category: Radiology Authors: Sodergren SC, Johnson CD, Gilbert A, Tomaszewski KA, Chu W, Chung HT, Dennis K, Desideri I, Glynne-Jones R, Grønlie Guren M, Kardamakis D, Nugent K, Schmidt H, Sebag-Montefiore D, Vassiliou V, EORTC Quality of Life Group Tags: Radiother Oncol Source Type: research

Interobserver variability in the delineation of the primary lung cancer and lymph nodes on different four-dimensional computed tomography reconstructions.
Abstract PURPOSE: The study compared interobserver variation in the delineation of the primary tumour (GTVp) and lymph nodes (GTVln) between three different 4DCT reconstruction types; Maximum Intensity Projection (MIP), Mid-Ventilation (Mid-V) and Mid-Position (Mid-P). MATERIAL AND METHODS: Seven radiation oncologists delineated the GTVp and GTVln on the MIP, Mid-V and Mid-P 4DCT image reconstructions of 10 lung cancer patients. The volumes, the mean standard deviation (SD) and distribution of SD (SD/area) over the median surface contour were compared for different tumour regions. RESULTS: The overall me...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 2, 2017 Category: Radiology Authors: Mercieca S, Belderbos JSA, De Jaeger K, Schinagl DAX, van der Voort Van Zijp N, Pomp J, Theuws J, Khalifa J, van de Vaart P, van Herk M Tags: Radiother Oncol Source Type: research

Clinical evaluation of atlas and deep learning based automatic contouring for lung cancer.
CONCLUSIONS: User adjustment of software generated contours is a viable strategy to reduce contouring time of OARs for lung radiotherapy while conforming to local clinical standards. In addition, deep learning contouring shows promising results compared to existing solutions. PMID: 29208513 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 2, 2017 Category: Radiology Authors: Lustberg T, van Soest J, Gooding M, Peressutti D, Aljabar P, van der Stoep J, van Elmpt W, Dekker A Tags: Radiother Oncol Source Type: research

Fragmentation level determines mitochondrial damage response and subsequently the fate of cancer cells exposed to carbon ions.
CONCLUSION: We proposed a stress response model to provide a mechanistic explanation for the mitochondrial damage response to high-LET carbon ions. PMID: 29208514 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 2, 2017 Category: Radiology Authors: Jin X, Zheng X, Li F, Liu B, Li H, Hirayama R, Li P, Liu X, Shen G, Li Q Tags: Radiother Oncol Source Type: research

Time and dose-related changes in lung perfusion after definitive radiotherapy for NSCLC.
CONCLUSION: Progressive dose dependent perfusion loss is manifested on SPECT up to 12 months following IMRT. These findings suggest that the dynamic change in perfusion may have prognostic value in predicting radiation pneumonitis in NSCLC patients treated with IMRT. PMID: 29203289 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 1, 2017 Category: Radiology Authors: Farr KP, Khalil AA, Møller DS, Bluhme H, Kramer S, Morsing A, Grau C Tags: Radiother Oncol Source Type: research

Patterns of locoregional failure in locally advanced non-small cell lung cancer treated with definitive conformal radiotherapy: Results from the Gating 2006 trial.
CONCLUSION: In-field failure was the most common pattern of failure. Escalated dose RT with high-dose fractions guided by PET parameters warrants further investigation. PMID: 29203290 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 1, 2017 Category: Radiology Authors: Jouglar E, Isnardi V, Goulon D, Ségura-Ferlay C, Ayadi M, Dupuy C, Douillard JY, Mahé MA, Claude L Tags: Radiother Oncol Source Type: research

Independent component analysis for rectal bleeding prediction following prostate cancer radiotherapy.
CONCLUSION: Among the many various extracted or calculated features, ICA parameters improved RB prediction following prostate cancer radiotherapy. PMID: 29203291 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 1, 2017 Category: Radiology Authors: Fargeas A, Acosta O, Ospina Arrango JD, Ferhat A, Costet N, Albera L, Azria D, Fenoglietto P, Créhange G, Beckendorf V, Hatt M, Kachenoura A, de Crevoisier R Tags: Radiother Oncol Source Type: research

Needle use and dosimetric evaluation in cervical cancer brachytherapy using the Utrecht applicator.
Abstract BACKGROUND AND PURPOSE: To analyse the clinical use of needles and examine the feasibility to meet the planning criteria in three fractions of cervical cancer brachytherapy. Furthermore, to investigate whether the needles with the largest discrepancy between application and loading are essential to treatment planning. MATERIALS AND METHODS: For 22 patients we analysed the applied and loaded needle patterns, and examined the dosimetric results for small (
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 29, 2017 Category: Radiology Authors: Smolic M, Sombroek C, Bloemers MCWM, van Triest B, Nowee ME, Mans A Tags: Radiother Oncol Source Type: research

Estimating the number of fractions by tumour site for European countries in 2012 and 2025: An ESTRO-HERO analysis.
DISCUSSION: An increase in the total number of fractions is expected in many European countries in the coming years following the trends in cancer incidence. In planning radiotherapy resources, these increases should be balanced to the evolution towards hypofractionation, along with increased complexity and quality assurance. PMID: 29198408 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 29, 2017 Category: Radiology Authors: Borras JM, Grau C, Corral J, Wong K, Barton MB, Ferlay J, Bray F, Lievens Y Tags: Radiother Oncol Source Type: research

Prognostic value of combining a quantitative image feature from positron emission tomography with clinical factors in oligometastatic non-small cell lung cancer.
CONCLUSIONS: Incorporating Energy strengthened a CPF model for predicting OS. These findings support further exploration of QIFs, including markers of the primary tumor vs. those of the metastatic sites. PMID: 29196095 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 28, 2017 Category: Radiology Authors: Jensen GL, Yost CM, Mackin DS, Fried DV, Zhou S, Court LE, Gomez DR Tags: Radiother Oncol Source Type: research

Delineation of the primary tumour Clinical Target Volumes (CTV-P) in laryngeal, hypopharyngeal, oropharyngeal and oral cavity squamous cell carcinoma: AIRO, CACA, DAHANCA, EORTC, GEORCC, GORTEC, HKNPCSG, HNCIG, IAG-KHT, LPRHHT, NCIC CTG, NCRI, NRG Oncology, PHNS, SBRT, SOMERA, SRO, SSHNO, TROG consensus guidelines.
CONCLUSION: Implementation of these guidelines in the daily practice of radiation oncology should contribute to reduce treatment variations from clinicians to clinicians, facilitate the conduct of multi-institutional clinical trials, and contribute to improved care of patients with head and neck carcinoma. PMID: 29180076 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 24, 2017 Category: Radiology Authors: Grégoire V, Evans M, Le QT, Bourhis J, Budach V, Chen A, Eisbruch A, Feng M, Giralt J, Gupta T, Hamoir M, Helito JK, Hu C, Hunter K, Johansen J, Kaanders J, Laskar SG, Lee A, Maingon P, Mäkitie A, Micciche' F, Nicolai P, O'Sullivan B, Poitevin A, Porced Tags: Radiother Oncol Source Type: research

Adjuvant breast radiotherapy: How to trade-off cost and effectiveness?
CONCLUSION: Hypofractionation may be considered the most relevant comparator for new strategies in adjuvant breast radiotherapy, with omission of radiotherapy as an interesting alternative in the very favourable subcategories, especially for partial breast techniques. Although comparison of CC and CEA is hampered by the variability in clinical and economic settings, HEE-based evidence can guide decision-making to tailor-made strategies, allocating the optimal treatment in terms of effectiveness as well as efficiency to the right indication. PMID: 29174721 [PubMed - as supplied by publisher] (Source: Radiotherapy and O...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 23, 2017 Category: Radiology Authors: Monten C, Lievens Y Tags: Radiother Oncol Source Type: research

Short interactive workshops reduce variability in contouring treatment volumes for spine stereotactic body radiation therapy: Experience with the ESTRO FALCON programme and EduCase ™ training tool.
We report the results of 4, 2-h contouring workshops on target volume definition for spinal stereotactic radiotherapy. They combined traditional teaching methods with a web-based contouring/contour-analysis platform and led to a significant reduction in delineation variability. Short, interactive workshops can reduce interobserver variability in spine SBRT target volume delineation. PMID: 29169657 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 20, 2017 Category: Radiology Authors: De Bari B, Dahele M, Palmu M, Kaylor S, Schiappacasse L, Guckenberger M, ESTRO FALCON core Tags: Radiother Oncol Source Type: research

Clinical decision support of radiotherapy treatment planning: A data-driven machine learning strategy for patient-specific dosimetric decision making.
CONCLUSIONS: We report on the first artificial-intelligence based clinical decision support system that connects patients to past discrete treatment plans in radiation oncology and demonstrate for the first time how this tool can enable clinicians to use past decisions to help inform current assessments. Clinicians can be informed of dose tradeoffs between critical structures early in the treatment process, enabling more time spent on finding the optimal course of treatment for individual patients. PMID: 29162279 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society f...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 18, 2017 Category: Radiology Authors: Valdes G, Simone CB, Chen J, Lin A, Yom SS, Pattison AJ, Carpenter CM, Solberg TD Tags: Radiother Oncol Source Type: research

Health-related-quality-of-life and toxicity after single fraction 19  Gy high-dose-rate prostate brachytherapy: Phase II trial.
CONCLUSIONS: BRT-HDR-19 Gy demonstrates excellent results in terms of toxicity, tolerance, safety, patient satisfaction and HRQoL. PMID: 29153462 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 15, 2017 Category: Radiology Authors: Gomez-Iturriaga A, Casquero F, Pijoan JI, Minguez P, Espinosa JM, Irasarri A, Bueso A, Cacicedo J, Buchser D, Bilbao P Tags: Radiother Oncol Source Type: research