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Automated delineation of the clinical target volume using anatomically constrained 3D expansion of the gross tumor volume.
CONCLUSIONS: Barrier structures for CTV definition can be auto-delineated with outstanding precision using a CNN. An algorithm for automated calculation of the CTV by 3D expansion of the GTV while respecting anatomical barriers has been developed. It shows good agreement with manual CTV definition for brain tumors. PMID: 32114264 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 26, 2020 Category: Radiology Authors: Shusharina N, Söderberg J, Edmunds D, Löfman F, Shih H, Bortfeld T Tags: Radiother Oncol Source Type: research

The prognostic value of volumetric changes of the primary tumor measured on Cone Beam-CT during radiotherapy for concurrent chemoradiation in NSCLC patients.
CONCLUSIONS: Three different subgroups of GTV-volume change during treatment were identified. Surprisingly, these subgroups did not differ in their risk of treatment outcomes. Only patients with a larger GTV at baseline had a significantly worse OS. Therefore, risk stratification at baseline might already be accurate in identifying the best treatment strategy for most patients. PMID: 32114265 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 26, 2020 Category: Radiology Authors: Kwint M, Stam B, Proust-Lima C, Philipps V, Hoekstra T, Aalbersberg E, Rossi M, Sonke JJ, Belderbos J, Walraven I Tags: Radiother Oncol Source Type: research

The use of real-world evidence to audit normal tissue complication probability models for acute esophageal toxicity in non-small cell lung cancer patients.
CONCLUSION: RWD is a useful method to audit NTCP models in clinical practice. The NTCP models to predict AET in NSCLC patients showed moderate predictive accuracy. For clinical practice, the V50Gy seems to be most stable for dose de-escalation without compromising safety and efficacy. PMID: 32114266 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 26, 2020 Category: Radiology Authors: Kwint MH, Walraven I, Verheij M, Sonke JJ, Belderbos JSA, Janssen TM Tags: Radiother Oncol Source Type: research

Pre-treatment radiomic features predict individual lymph node failure for head and neck cancer patients.
Abstract BACKGROUND AND PURPOSE: To develop and validate a pre-treatment radiomics-based prediction model to identify pathological lymph nodes (pLNs) at risk of failures after definitive radiotherapy in head and neck squamous cell carcinoma patients. MATERIALS AND METHODS: Training and validation cohorts consisted of 165 patients with 558 pLNs and 112 patients with 467 pLNs, respectively. All patients were primarily treated with definitive radiotherapy, with or without systemic treatment. The endpoint was the cumulative incidence of nodal failure. For each pLN, 82 pre-treatment CT radiomic features and 7 clin...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 26, 2020 Category: Radiology Authors: Zhai TT, Langendijk JA, van Dijk LV, van der Schaaf A, Sommers L, Vemer-van den Hoek JGM, Bijl HP, Halmos GB, Witjes MJH, Oosting SF, Noordzij W, Sijtsema NM, Steenbakkers RJHM Tags: Radiother Oncol Source Type: research

Quantitative imaging for radiotherapy purposes.
Abstract Quantitative imaging biomarkers show great potential for use in radiotherapy. Quantitative images based on microscopic tissue properties and tissue function can be used to improve contouring of the radiotherapy targets. Furthermore, quantitative imaging biomarkers might be used to predict treatment response for several treatment regimens and hence be used as a tool for treatment stratification, either to determine which treatment modality is most promising or to determine patient-specific radiation dose. Finally, patient-specific radiation doses can be further tailored to a tissue/voxel specific radiation...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 26, 2020 Category: Radiology Authors: Gurney-Champion OJ, Mahmood F, van Schie M, Julian R, George B, Philippens MEP, van der Heide UA, Thorwarth D, Redalen KR Tags: Radiother Oncol Source Type: research

Single fraction radiosurgery, fractionated radiosurgery, and conventional radiotherapy for spinal oligometastasis (SAFFRON): A systematic review and meta-analysis.
Abstract BACKGROUND AND PURPOSE: To perform a systematic review/meta-analysis of outcomes for patients with spinal metastases treated with stereotactic radiosurgery (SRS) (either single-fraction (SF-SRS) or multiple-fraction (MF-SRS)) or conventional radiotherapy (RT). MATERIALS AND METHODS: Thirty-seven studies were identified. Primary outcomes were 1-year local control (LC) and acute/late grade 3-5 toxicities (including vertebral compression fractures (VCF)). Weighted random effects meta-analyses using the DerSimonian and Laird methods and meta-regressions were conducted to characterize and compare effect s...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 26, 2020 Category: Radiology Authors: Singh R, Lehrer EJ, Dahshan B, Palmer JD, Sahgal A, Gerszten PC, Zaorsky NG, Trifiletti DM Tags: Radiother Oncol Source Type: research

Target motion mitigation promotes high-precision treatment planning and delivery of extreme hypofractionated prostate cancer radiotherapy: Results from a phase II study.
CONCLUSION: The unique spatial configuration of this prostate motion mitigation protocol enabled precise treatment planning and delivery that optimized outcomes of ultra-high 5 × 9 Gy hypofractionated radiotherapy of organ-confined prostate cancer. PMID: 32087469 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 18, 2020 Category: Radiology Authors: Greco C, Pares O, Pimentel N, Louro V, Morales J, Nunes B, Vasconcelos AL, Antunes I, Kociolek J, Stroom J, Viera S, Mateus D, Cardoso MJ, Soares A, Marques J, Freitas E, Coelho G, Fuks Z Tags: Radiother Oncol Source Type: research

In Regard to Fernando et al.: Synchronous versus sequential chemo-radiotherapy in patients with early stage breast cancer (SECRAB): A randomised, phase III, trial.
PMID: 32085932 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 17, 2020 Category: Radiology Authors: Gultekin M, Tilki B, Yildiz F Tags: Radiother Oncol Source Type: research

Pattern of relapse and dosimetric analysis of a single dose 19  Gy HDR-brachytherapy phase II trial.
CONCLUSIONS: This dosimetric analysis demonstrates a dose-response relationship in patients treated with single fraction 19 Gy. Patients with intermediate risk disease, with visible DIL on mpMRI and patients treated with cooler implants have higher incidence of biochemical and local failure. PMID: 32086047 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 17, 2020 Category: Radiology Authors: Gomez-Iturriaga A, Buchser D, Mayrata E, San Miguel I, Gonzalez A, Suarez F, Martinez-Indart L, Minguez P, Espinosa J, Perez F, Cacicedo J, Casquero F Tags: Radiother Oncol Source Type: research

First magnetic resonance imaging-guided cardiac radioablation of sustained ventricular tachycardia.
CONCLUSION: Real-time tracking and beam-gating were successfully applied in this first MRgRA to treat sustained VT. PMID: 32067819 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 13, 2020 Category: Radiology Authors: Mayinger M, Kovacs B, Tanadini-Lang S, Ehrbar S, Wilke L, Chamberlain M, Moreira A, Weitkamp N, Brunckhorst C, Duru F, Steffel J, Breitenstein A, Alkadhi H, Garcia Schueler HI, Manka R, Ruschitzka F, Guckenberger M, Saguner AM, Andratschke N Tags: Radiother Oncol Source Type: research

Examining geographic accessibility to radiotherapy in Canada and Greenland for indigenous populations: Measuring inequities to inform solutions.
CONCLUSIONS: Geography is an important barrier to accessing radiotherapy for indigenous populations in Canada and Greenland. A significant disparity exists between indigenous and non-indigenous peoples in Canada. Geospatial analyses can help highlight disparities in access to inform radiotherapy service planning. PMID: 32065874 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 13, 2020 Category: Radiology Authors: Chan J, Friborg J, Zubizarreta E, van Eck JW, Hanna TP, Bourque JM, Gaudet M, Dennis K, Olson R, Coleman CN, Petersen AJ, Grau C, Abdel-Wahab M, Brundage M, Slotman B, Polo A Tags: Radiother Oncol Source Type: research

Development and validation of a radiomics signature on differentially expressed features of 18F-FDG PET to predict treatment response of concurrent chemoradiotherapy in thoracic esophagus squamous cell carcinoma.
Abstract BACKGROUND AND PURPOSE: To investigate potential image markers for early prediction of treatment response on thoracic esophagus squamous cell carcinoma (ESCC) treated with concurrent chemoradiotherapy (CCRT). MATERIALS AND METHODS: 159 thoracic ESCC patients enrolled from two institutions were divided into training and validation sets. A total of 944 radiomics features were extracted from pretreatment 18F-FDG PET images. We first performed the inter-observer reproducibility test in 10 pairs of patients (responders vs. nonresponders), and the limma package was used to identify differentially expressed...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 13, 2020 Category: Radiology Authors: Cao Q, Li Y, Li Z, An D, Li B, Lin Q Tags: Radiother Oncol Source Type: research

The financial impact of SBRT for oligometastatic disease: A population-level analysis in Belgium.
CONCLUSION: Although the financial impact of SBRT for OMD in Belgium is forecasted to remain acceptable, even in extreme scenarios, further clinical trials and real-life clinical and financial monitoring with prospective data gathering are necessary to refine the data. PMID: 32065901 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 13, 2020 Category: Radiology Authors: Nevens D, Kindts I, Defourny N, Boesmans L, Van Damme N, Engels H, Van de Voorde C, Lievens Y Tags: Radiother Oncol Source Type: research

MRI predicts increased eligibility for sphincter preservation after CRT in low rectal cancer.
Abstract Chemoradiation increases the eligibility for sphincter preservation in low rectal cancer, as assessed by MRI. INTRODUCTION: We evaluated whether MRI can predict sphincter preservation after chemoradiation (CRT), and whether the feasibility of sphincter preservation increases after CRT, when compared with MRI before neoadjuvant treatment. METHODS: 85 patients with low rectal tumour (≤5 cm from anorectal junction (ARJ)) were included. Radiologist and a surgeon measured the tumour distance to ARJ, and assigned confidence level scores (CLS) for the feasibility of sphincter preserving surgery...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 13, 2020 Category: Radiology Authors: Krdzalic J, Beets-Tan RGH, Engelen SME, van Griethuysen J, Lahaye MJ, Lambregts DMJ, Bakers FCH, Vliegen RFA, Beets GL, Maas M Tags: Radiother Oncol Source Type: research

Post-mastectomy radiotherapy is associated with improved overall survival in T3N0 patients who do not receive chemotherapy.
Abstract BACKGROUND AND PURPOSE: There is limited retrospective evidence addressing the utility of post-mastectomy radiotherapy (PMRT) in patients with T3N0 breast cancer. We performed a retrospective analysis of the National Cancer Database (NCDB) comparing overall survival (OS) in T3N0 patients treated with mastectomy alone (MTX) or with PMRT. MATERIALS AND METHODS: We performed a matched-cohort analysis of NCDB breast cancer patients with pT3N0 disease who did not receive NAC, or cT3N0 patients who received NAC treated between 2006 and 2014. Patients were matched for all available baseline characteristics ...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 13, 2020 Category: Radiology Authors: Almahariq MF, Quinn TJ, Siddiqui ZA, Thompson AB, Jawad MS, Chen PY, Gustafson GS, Dilworth JT Tags: Radiother Oncol Source Type: research

An improved method for analyzing and reporting patterns of in-field recurrence after stereotactic ablative radiotherapy in early-stage non-small cell lung cancer.
We describe a method for analyzing and reporting patterns of in-field recurrence after SABR, incorporating dosimetric parameters from initial treatment plan as well as geometric information from diagnostic images at recurrence. MATERIAL AND METHODS: Diagnostic CT images at recurrence were registered with initial treatment planning images and radiation dose by deformable image registration. Recurrent gross tumor volume (rGTV) and centroid (geometric center of rGTV) were delineated. In-field failure was classified as centroids originating within the original planning target volume. Dose-volume histograms for each rGTV w...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 12, 2020 Category: Radiology Authors: Nantavithya C, Gomez DR, Chang JY, Mohamed ASR, Fuller CD, Li H, Brooks ED, Gandhi SJ Tags: Radiother Oncol Source Type: research

Quantifying the dose accumulation uncertainty after deformable image registration in head-and-neck radiotherapy.
CONCLUSION: The uncertainty in accumulated dose using DIR can be accurately quantified and incorporated in dose-volume histograms (DVHs). This method can be used to prospectively assess the adequacy of target coverage during treatment in an objective manner. PMID: 32063377 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 12, 2020 Category: Radiology Authors: Lowther NJ, Marsh SH, Louwe RJW Tags: Radiother Oncol Source Type: research

Radiotherapy after primary CHEMotherapy (RAPCHEM): Practice variation in a Dutch registration study (BOOG 2010-03).
CONCLUSION: Substantial deviation from the SG for post-operative RT was observed after PST, especially in patients with an intermediate-risk. Future analyses will evaluate outcome of these patients in relation to risk factors and the actual RT given. PMID: 32058873 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 9, 2020 Category: Radiology Authors: Boersma LJ, Verloop J, Voogd AC, Elkhuizen PHM, Houben R, van Leeuwen AE, Linn S, de Munck L, Pijnappel R, Strobbe L, van Dalen T, Wesseling J, Poortmans P Tags: Radiother Oncol Source Type: research

Auto-segmentation of pancreatic tumor in multi-parametric MRI using deep convolutional neural networks.
CONCLUSION: We developed a CNN-based model for auto-segmentation of pancreatic GTV in multi-parametric MRI. Model performance was comparable to expert radiation oncologists. This model provides a framework to incorporate multimodality images and daily MRI for GTV auto-segmentation in MRgOART. PMID: 32045787 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 7, 2020 Category: Radiology Authors: Liang Y, Schott D, Zhang Y, Wang Z, Nasief H, Paulson E, Hall W, Knechtges P, Erickson B, Li XA Tags: Radiother Oncol Source Type: research

Response to Gultekin et al. regarding SECRAB trial toxicity.
PMID: 32046873 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 7, 2020 Category: Radiology Authors: Fernando IN, Lax S, Ahmed I Tags: Radiother Oncol Source Type: research

Randomized clinical trial on reduction of radiotherapy dose to the elective neck in head and neck squamous cell carcinoma; update of the long-term tumor outcome.
CONCLUSION: At 5-years, no statistically significant differences regarding OS, local recurrence, RR nor distant metastases were observed between both treatment arms. This study is underpowered to undoubtedly demonstrate non-inferiority. However, since in both arms only two RR in the PTVelect were observed, reducing the dose to PTVelect appears safe and should be further investigated. PMID: 32044165 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 6, 2020 Category: Radiology Authors: Sarah D, Daan N, Frederic D, Jean-François D, Rüveyda D, Annouschka L, Mia V, Wilfried N, Sandra N Tags: Radiother Oncol Source Type: research

Single dose high-dose rate (HDR) brachytherapy (BT) as monotherapy for localised prostate cancer: Early results of a UK national cohort study.
CONCLUSION: This is the largest cohort of single dose HDR brachytherapy patients treated with a single dose published to date. It shows that with 19 Gy there is 100% bRFS at 3 years in low risk patients but results in intermediate and high risk groups are less encouraging falling to 86% and 75% at 3 years with relapse predominantly in the prostate. Limited by the short follow up period of this study, the long-term outcomes of this single dose HDR approach remains uncertain. It is important to have close ongoing surveillance of this cohort as the data matures. PMID: 32044166 [PubMed - as supplied by publ...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 6, 2020 Category: Radiology Authors: Tharmalingam H, Tsang Y, Ostler P, Wylie J, Bahl A, Lydon A, Ahmed I, Elwell C, Nikapota AR, Hoskin PJ, National UK HDR Prostate Brachytherapy Database Tags: Radiother Oncol Source Type: research

Corrigendum to "Including anatomical variations in robust optimization for head and neck proton therapy can reduce the need of adaptation" [Radiother Oncol 131 (2019) 127-134].
Corrigendum to "Including anatomical variations in robust optimization for head and neck proton therapy can reduce the need of adaptation" [Radiother Oncol 131 (2019) 127-134]. Radiother Oncol. 2020 Feb 07;: Authors: Cubillos-Mesías M, Troost EGC, Lohaus F, Agolli L, Rehm M, Richter C, Stützer K PMID: 32044167 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 6, 2020 Category: Radiology Authors: Cubillos-Mesías M, Troost EGC, Lohaus F, Agolli L, Rehm M, Richter C, Stützer K Tags: Radiother Oncol Source Type: research

Neoadjuvant treatment strategies for resectable pancreas cancer: A propensity-matched analysis of the National Cancer Database.
CONCLUSIONS: Neoadjuvant chemotherapy with SBRT is associated with favorable survival and pathological outcomes, warranting consideration for prospective validation. PMID: 32044168 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 6, 2020 Category: Radiology Authors: Xiang M, Heestand GM, Chang DT, Pollom EL Tags: Radiother Oncol Source Type: research

Effectivity and applicability of the German DEGRO/DGK-guideline for radiotherapy in CIED-bearing patients.
CONCLUSIONS: Implementation of the German DEGRO/DGK-guideline effectively prevented radiation-associated CIED failures in patients treated with photons. Limitation of photon energy to 6 MV, suspension of defibrillation therapy in ICDs, surveillance of patients according to risk stratification and avoidance of direct irradiation of CIEDs should become standard of care. PMID: 32044169 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 6, 2020 Category: Radiology Authors: Gauter-Fleckenstein B, Barthel C, Büttner S, Wenz F, Borggrefe M, Tülümen E Tags: Radiother Oncol Source Type: research

Neurocognitive function and quality of life after proton beam therapy for brain tumour patients.
CONCLUSION: Self-reported and objectively measured neurocognition and most other QoL domains remained largely stable over time during recurrence-free follow-up for brain tumour patients treated with PBT. The association between reduced cognitive function and irradiated volume of the anterior cerebellum requires validation in larger studies and comparison to patients treated with photon therapy. PMID: 32044170 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 6, 2020 Category: Radiology Authors: Dutz A, Agolli L, Bütof R, Valentini C, Baumann M, Lühr A, Löck S, Krause M Tags: Radiother Oncol Source Type: research

Fecal microbiota transplantation: A promising treatment for radiation enteritis?
CONCLUSION: The present case series first demonstrated that FMT might be safe and effective to improve intestinal symptoms and mucosal injury in patients with CRE for a period of time. Trial registration ID: NCT03516461. PMID: 32044171 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 6, 2020 Category: Radiology Authors: Ding X, Li Q, Li P, Chen X, Xiang L, Bi L, Zhu J, Huang X, Cui B, Zhang F Tags: Radiother Oncol Source Type: research

Risk stratification of symptomatic brain metastases by clinical and FDG PET parameters for selective use of prophylactic cranial irradiation in patients with extensive disease of small cell lung cancer.
Abstract PURPOSE: To identify risk factors for developing symptomatic brain metastases and evaluate the impact of prophylactic cranial irradiation (PCI) on brain metastasis-free survival (BMFS) and overall survival (OS) in extensive disease small cell lung cancer (ED-SCLC). MATERIALS AND METHODS: Among 190 patients diagnosed with ED-SCLC who underwent FDG PET/CT and brain Magnetic Resonance Imaging (MRI) prior to treatment, 53 (27.9%) received PCI while 137 (72.1%) did not. Prognostic index predicting a high risk of symptomatic brain metastases was calculated for the group without receiving PCI (observation g...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 6, 2020 Category: Radiology Authors: Chung JH, Kang SY, Wu HG, Seo YS, Kim DW, Kang KW, Kim HJ, Cheon GJ Tags: Radiother Oncol Source Type: research

Comparing local control and distant metastasis in NSCLC patients between CyberKnife and conventional SBRT.
This study included 422 stage I NSCLC patients from 2 institutions who received SBRT: 217 treated conventionally and 205 with CyberKnife. The dose behavior outside the PTV of both sub-cohorts were compared by analyzing the mean dose in continuous shells extending 1, 2, 3, …, 100 mm from the PTV. Kaplan-Meier analysis was performed between the two sub-cohorts with respect to DM-free survival and local progression-free survival. A multivariable Cox proportional hazards model was fitted to the combined cohort (n = 422) with respect to DM incidence and local failure. RESULTS: The shell-averaged dose ...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 6, 2020 Category: Radiology Authors: Diamant A, Heng VJ, Chatterjee A, Faria S, Bahig H, Filion E, Doucet R, Khosrow-Khavar F, Naqa IE, Seuntjens J Tags: Radiother Oncol Source Type: research

Randomized phase-III-trial of concurrent chemoradiation for locally advanced head and neck cancer comparing dose reduced radiotherapy with paclitaxel/cisplatin to standard radiotherapy with fluorouracil/cisplatin: The PacCis-trial.
CONCLUSION: Paclitaxel/cisplatin-CRT with a reduced RT-dose is not superior to standard fluorouracil/cisplatin-CRT. Subgroup analyses indicate that a reduced radiation dose seems to be sufficient for p16+ oropharyngeal cancer or non-smokers. CLINICAL TRIAL INFORMATION: NCT01126216; EudraCT Number 2005-003484-23. PMID: 32044419 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 6, 2020 Category: Radiology Authors: Fietkau R, Hecht M, Hofner B, Lubgan D, Iro H, Gefeller O, Rödel C, Hautmann MG, Kölbl O, Salay A, Rübe C, Melchior P, Breinl P, Krings W, Gripp S, Wollenberg B, Keerl R, Schreck U, Siekmeyer B, Grabenbauer GG, Balermpas P, PacCis-Study Group Tags: Radiother Oncol Source Type: research

Feasibility and impact of national peer reviewed clinical audits in radiotherapy departments.
CONCLUSION: This first round of audits in Belgium allowed for the identification of common areas for improvements of practice in radiation oncology departments, with a focus on process optimization and infrastructure elements. Similarly, the audits' emitted recommendations were globally deemed very relevant. Encouraged, by this analysis, a second cycle of audits has started in Belgium with a modified version of the QUATRO document (B-QUATRO). PMID: 32044420 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 6, 2020 Category: Radiology Authors: Aude V, Yolande L, Pierre S, Belgian College for Physicians in Radiation Oncology Tags: Radiother Oncol Source Type: research

Dose assessment for patients with stage I non-small cell lung cancer receiving passive scattering carbon-ion radiotherapy using daily computed tomographic images: A prospective study.
This study aimed to assess dose distributions for stage I non-small cell lung cancer (NSCLC) with passive scattering carbon-ion radiotherapy (C-ion RT) using daily computed tomography (CT) images. MATERIALS AND METHODS: We enrolled 10 patients with stage I NSCLC and acquired a total of 40 pre-fractional CT image series under the same settings as the planning CT images. These CT images were registered with planning CT images for dose evaluation using both bone matching (BM) and tumor matching (TM). Using deformable image registration, we generated accumulated doses. Moreover, the volumetric dose parameters were compare...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 6, 2020 Category: Radiology Authors: Li Y, Kubota Y, Kubo N, Mizukami T, Sakai M, Kawamura H, Irie D, Okano N, Tsuda K, Matsumura A, Saitoh JI, Nakano T, Ohno T Tags: Radiother Oncol Source Type: research

Reirradiation of salivary gland tumors with carbon ion radiotherapy at CNAO.
CONCLUSIONS: CIRT is a good option for retreatment of inoperable recurrent salivary gland tumors with acceptable rates of acute and late toxicity. Longer follow up time is needed to assess the effectiveness of CIRT in reirradiation setting of salivary gland tumors. PMID: 32044529 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 6, 2020 Category: Radiology Authors: Vischioni B, Dhanireddy B, Severo C, Bonora M, Ronchi S, Vitolo V, Fiore MR, D'Ippolito E, Petrucci R, Barcellini A, Ciurlia E, Iannalfi A, Hasegawa A, Molinelli S, Mirandola A, Valvo F, Orecchia R Tags: Radiother Oncol Source Type: research

Stereotactic ablative radiation therapy for pulmonary metastases: Improving overall survival and identifying subgroups at high risk of local failure.
Abstract BACKGROUND & PURPOSE: Stereotactic ablative radiation therapy (SABR) is an emerging treatment option for patients with pulmonary metastases; identifying patients who would benefit from SABR can improve outcomes. MATERIALS & METHODS: We retrospectively analyzed local failure (LF), distant failure (DF), overall survival (OS), and toxicity in 317 patients with 406 pulmonary metastases treated with SABR in January 2006-September 2017 at a tertiary cancer center. RESULTS: Median follow-up time was 23 months. Primary adrenal, colorectal, sarcoma, or pancreatic ("less responsive"...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 6, 2020 Category: Radiology Authors: Pasalic D, Lu Y, Betancourt-Cuellar SL, Taku N, Mesko SM, Bagley AF, Chance WW, Allen PK, Tang C, Antonoff MB, Balter PA, Mehran RJ, Welsh JW, Liao Z, Gomez D, Erasmus JJ, Nguyen QN Tags: Radiother Oncol Source Type: research

Automatic delineation of the clinical target volume and organs at risk by deep learning for rectal cancer postoperative radiotherapy.
Abstract BACKGROUND AND PURPOSE: Manual delineation of clinical target volumes (CTVs) and organs at risk (OARs) is time-consuming, and automatic contouring tools lack clinical validation. We aimed to construct and validate the use of convolutional neural networks (CNNs) to set better contouring standards for rectal cancer radiotherapy. MATERIALS AND METHODS: We retrospectively collected and evaluated computed tomography (CT) scans of 199 rectal cancer patients treated at our hospital from February 2018 to April 2019. Two CNNs-DeepLabv3+ for extracting high-level semantic information and ResUNet for extracting...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 6, 2020 Category: Radiology Authors: Song Y, Hu J, Wu Q, Xu F, Nie S, Zhao Y, Bai S, Yi Z Tags: Radiother Oncol Source Type: research

Corrigendum to "A feasibility study of high-dose hypofractionated carbon ion radiation therapy using four fractions for localized hepatocellular carcinoma measuring 3  cm or larger" [Radiother. Oncol. 132 (2019) 230-235].
Corrigendum to "A feasibility study of high-dose hypofractionated carbon ion radiation therapy using four fractions for localized hepatocellular carcinoma measuring 3 cm or larger" [Radiother. Oncol. 132 (2019) 230-235]. Radiother Oncol. 2020 Jan 30;: Authors: Shibuya K, Ohno T, Katoh H, Okamoto M, Shiba S, Koyama Y, Kakizaki S, Shirabe K, Nakano T PMID: 32008869 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 29, 2020 Category: Radiology Authors: Shibuya K, Ohno T, Katoh H, Okamoto M, Shiba S, Koyama Y, Kakizaki S, Shirabe K, Nakano T Tags: Radiother Oncol Source Type: research

Impact of internal target volume definition for pencil beam scanned proton treatment planning in the presence of respiratory motion variability for lung cancer: A proof of concept.
CONCLUSION: Irregular respiration significantly affects CTV coverage when ITVs are only defined by single 4DCTs. A probabilistic ITV50 provides an adequate compromise between target coverage and lung dose for most motion and patient scenarios investigated. PMID: 32007759 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 29, 2020 Category: Radiology Authors: Krieger M, Giger A, Salomir R, Bieri O, Celicanin Z, Cattin PC, Lomax AJ, Weber DC, Zhang Y Tags: Radiother Oncol Source Type: research

Hospital variance in neoadjuvant rectal cancer treatment and the influence of a national guideline update: Results of a nationwide population-based study.
JHW Abstract INTRODUCTION: The aim of this study was to examine the hospital variation in neoadjuvant treatment of rectal cancer according to the different risk groups (low-, intermediate- and high-risk) and evaluate the influence on survival. MATERIALS AND METHODS: Patients with non-metastasized rectal cancer diagnosed between 2009 and 2016 were selected from the Netherlands Cancer Registry. The observed and case-mix adjusted distribution of the different neoadjuvant treatment schemes (none, radiotherapy (RT), chemoradiotherapy (CRT)) by hospital of diagnosis were generated for each risk group in the cohorts...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 29, 2020 Category: Radiology Authors: Koëter T, Elferink MA, Verhoeven RHA, Zimmerman DDE, Wasowicz DK, Verheij M, de Wilt JHW Tags: Radiother Oncol Source Type: research

Radical (chemo)radiotherapy in oropharyngeal squamous cell carcinoma: Comparison of TNM 7th and 8th staging systems.
CONCLUSION: The 8th edition TNM staging system provides better OS stratification in oropharyngeal cancer after definitive CRT compared with the 7th edition. Other clinical variables, such as complete response at 3 months, alcohol and tobacco smoking, should also be considered in future classifications as they provide additional risk stratification information in both HPV-positive and HPV-negative disease. PMID: 31981964 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 21, 2020 Category: Radiology Authors: De Felice F, Bird T, Michaelidou A, Thavaraj S, Odell E, Sandison A, Hall G, Morgan P, Lyons A, Cascarini L, Fry A, Oakley R, Simo R, Jeannon JP, Lei M, Guerrero Urbano T Tags: Radiother Oncol Source Type: research

Variation in radiotherapy patterns of care in the radical treatment of South Australian men with non-metastatic prostate cancer between 2005-2015.
Abstract BACKGROUND AND PURPOSE: To investigate associations between socio-demographic characteristics and radiotherapy patterns of care in non-metastatic prostate cancer [nmPCa] in South Australia [SA] between 2005-2015 and document practice patterns over time. MATERIALS AND METHODS: Men with nmPCa receiving primary curative radiotherapy were identified from SA Prostate Cancer Clinical Outcomes Collaborative database. Adjuvant, salvage and palliative therapies were excluded. Associations between socio-demographic factors (age, residence, socio-economic status, diagnostic period) and radiotherapy mode (extern...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 20, 2020 Category: Radiology Authors: Morias S, Buckley E, Beckmann K, O'Callaghan M, Borg M, Short M Tags: Radiother Oncol Source Type: research

Interaction between CIEDs and modern radiotherapy techniques: Flattening filter free-VMAT, dose-rate effects, scatter radiation, and neutron-generating energies.
CONCLUSIONS: 6 MV FFF-VMAT is safe even at high dose-rates of 2500 cGy/min, regardless whether CIEDs are located close (2.5 cm) or distant (35 cm) to the radiation beam. CIEDs should never be placed within radiation and energy should always be limited to 6 MV. At 6 MV, VMAT at high dose-rates can be used to treat tumors, which are located close to CIEDs. PMID: 31973882 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 19, 2020 Category: Radiology Authors: Gauter-Fleckenstein B, Nguyen J, Jahnke L, Gaiser T, Rudic B, Büttner S, Wenz F, Borggrefe M, Tülümen E Tags: Radiother Oncol Source Type: research

Authors' Response to Letter to the Editor "Comments on 'Risk factors for vertebral compression fracture after spine stereotactic body radiation therapy: Long-term results of a prospective phase 2 study'".
Authors' Response to Letter to the Editor "Comments on 'Risk factors for vertebral compression fracture after spine stereotactic body radiation therapy: Long-term results of a prospective phase 2 study'". Radiother Oncol. 2020 Jan 18;145:125-126 Authors: Mantel F, Guckenberger M PMID: 31962253 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 17, 2020 Category: Radiology Authors: Authors' Response to Letter to the Editor "Comments on 'Risk factors for vertebral compression fracture after spine stereotactic body radiation therapy: Long-term results of a prospective phase 2 study'". Tags: Radiother Oncol Source Type: research

Comments on "Risk factors for vertebral compression fracture after spine stereotactic body radiation therapy: Long-term results of a prospective phase 2 study".
Comments on "Risk factors for vertebral compression fracture after spine stereotactic body radiation therapy: Long-term results of a prospective phase 2 study". Radiother Oncol. 2020 Jan 18;145:127 Authors: Yilmaz MT, Hurmuz P PMID: 31962254 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 17, 2020 Category: Radiology Authors: Yilmaz MT, Hurmuz P Tags: Radiother Oncol Source Type: research

Selective effects of radiotherapy on viability and function of invariant natural killer T cells in vitro.
DISCUSSION: Exposure of iNKT cell to radiation can negatively affect their viability and function. PMID: 31962255 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 17, 2020 Category: Radiology Authors: Melo AM, Maher SG, O'Leary SM, Doherty DG, Lysaght J Tags: Radiother Oncol Source Type: research

FLASH-radiotherapy: A new perspective in immunotherapy era?
PMID: 31962256 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 17, 2020 Category: Radiology Authors: Yilmaz MT, Hurmuz P, Yazici G Tags: Radiother Oncol Source Type: research

MRI-detected residual retropharyngeal lymph node after intensity-modulated radiotherapy in nasopharyngeal carcinoma: Prognostic value and a nomogram for the pretherapy prediction of it.
CONCLUSION: MRI-detected RRLN at three months after IMRT was an unfavorable prognostic factor for patients with NPC. We developed and validated an easy-to-use nomogram for the pretherapy prediction of RRLN. PMID: 31931288 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 9, 2020 Category: Radiology Authors: Li WZ, Liu GY, Lin LF, Lv SH, Qiang MY, Lv X, Wu YS, Liang H, Ke LR, Wang DL, Yu YH, Qiu WZ, Liu KY, Guo X, Li JP, Zou YJ, Xiang YQ, Xia WX Tags: Radiother Oncol Source Type: research

Radiation therapy to the primary tumor for de novo metastatic breast cancer and overall survival in a retrospective multicenter cohort analysis.
, Mouret-Reynier MA, Petit T, Courtinard C, Filleron T, Robain M, Dalenc F Abstract BACKGROUND: The impact of locoregional treatment (LRT) on overall survival (OS) in de novo metastatic breast cancer (dnMBC) is still under debate, with very few data available regarding exclusive radiotherapy (ERT) as a therapeutic modality. METHODS: We evaluated the impact of ERT, exclusive surgery, or a combination of surgery plus radiotherapy (bimodality therapy, BMT) on survival outcomes in a national real-life dnMBC cohort. The primary and secondary end points were OS and progression free survival (PFS) according to LRT (...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 9, 2020 Category: Radiology Authors: Pons-Tostivint E, Kirova Y, Lusque A, Campone M, Geffrelot J, Rivera S, Mailliez A, Pasquier D, Madranges N, Firmin N, Crouzet A, Gonçalves A, Jankowski C, De La Motte Rouge T, Pouget N, De La Lande B, Mouttet-Boizat D, Ferrero JM, Uwer L, Eymard JC, Mou Tags: Radiother Oncol Source Type: research

MRI-based contouring of functional sub-structures of the lower urinary tract in gynaecological radiotherapy.
l L Abstract INTRODUCTION: Research in radiation-induced urinary morbidity is limited by lack of guidelines for contouring and dose assessment of the lower urinary tract. Based on literature regarding anatomy, physiology and imaging of the lower urinary tract, this study aimed to provide advice on contouring of relevant sub-structures, reference points and reference dimensions for gynaecological radiotherapy. MATERIAL AND METHODS: 210 MRIs for Image-Guided Adaptive Brachytherapy (IGABT) were analysed in 105 locally advanced cervical cancer patients treated with radio(chemo)therapy. Sub-structures (trigone, bl...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 9, 2020 Category: Radiology Authors: Spampinato S, Tanderup K, Marinovskij E, Axelsen S, Pedersen EM, Pötter R, Lindegaard JC, Fokdal L Tags: Radiother Oncol Source Type: research

Automatic reconstruction of the delivered dose of the day using MR-linac treatment log files and online MR imaging.
CONCLUSIONS: The presented end-to-end workflow is able to reliably, non-invasively and automatically reconstruct the delivered prostate radiotherapy dose by processing MR-linac treatment log files and online MR images. In the future, we envision this workflow to be adapted to other cancer sites and ultimately to enter widespread clinical use. PMID: 31931291 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 9, 2020 Category: Radiology Authors: Menten MJ, Mohajer JK, Nilawar R, Bertholet J, Dunlop A, Pathmanathan AU, Moreau M, Marshall S, Wetscherek A, Nill S, Tree AC, Oelfke U Tags: Radiother Oncol Source Type: research

Lymphopenia during radiotherapy in patients with oropharyngeal cancer.
CONCLUSION: In this large cohort of patients with oropharyngeal cancer, the development of lymphopenia during radiotherapy did not impact outcomes. PMID: 31931292 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 9, 2020 Category: Radiology Authors: Ng SP, Bahig H, Jethanandani A, Pollard C, Berends J, Sturgis EM, Johnson FM, Elgohari B, Elhalawani H, Rosenthal DI, Skinner HD, Gunn GB, Phan J, Frank SJ, Mohamed ASR, Fuller CD, Garden AS Tags: Radiother Oncol Source Type: research