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Comparison of SUVmax and SUVpeak based segmentation to determine primary lung tumour volume on FDG PET-CT correlated with pathology data.
CONCLUSION: No benefit was shown on clinical data for the SUVpeak based segmentation method over a SUVmax based one. Both methods can be used to determine the tumour volumes in resected NSCLC tumours. PMID: 29983260 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 5, 2018 Category: Radiology Authors: Mercieca S, Belderbos J, van Loon J, Gilhuijs K, Julyan P, van Herk M Tags: Radiother Oncol Source Type: research

Predictors for poor cosmetic outcome in patients with early stage breast cancer treated with breast conserving therapy: Results of the Young boost trial.
CONCLUSION: Important risk factors for worse CO were the use of a photon boost instead of an electron boost, a high boost dose, cosmesis at baseline, adjuvant chemotherapy and boost volume. These results can be used to define strategies aimed at improving CO. PMID: 29980320 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 3, 2018 Category: Radiology Authors: Brouwers PJAM, van Werkhoven E, Bartelink H, Fourquet A, Lemanski C, van Loon J, Maduro JH, Russell NS, Scheijmans LJEE, Schinagl DAX, Westenberg AH, Poortmans P, Boersma LJ, Young Boost Trial research group Tags: Radiother Oncol Source Type: research

Fully automated, multi-criterial planning for Volumetric Modulated Arc Therapy - An international multi-center validation for prostate cancer.
Abstract BACKGROUND AND PURPOSE: Reported plan quality improvements with autoplanning of radiotherapy of the prostate and seminal vesicles are poor. A system for automated multi-criterial planning has been validated for this treatment in a large international multi-center study. The system is configured with training plans using a mechanism that strives for quality improvements relative to those plans. MATERIAL AND METHODS: Each of the four participating centers included thirty manually generated clinical Volumetric Modulated Arc Therapy prostate plans (manVMAT). Ten plans were used for autoplanning training....
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 30, 2018 Category: Radiology Authors: Heijmen B, Voet P, Fransen D, Penninkhof J, Milder M, Akhiat H, Bonomo P, Casati M, Georg D, Goldner G, Henry A, Lilley J, Lohr F, Marrazzo L, Pallotta S, Pellegrini R, Seppenwoolde Y, Simontacchi G, Steil V, Stieler F, Wilson S, Breedveld S Tags: Radiother Oncol Source Type: research

Radiotherapy dose-volume parameters predict videofluoroscopy-detected dysphagia per DIGEST after IMRT for oropharyngeal cancer: Results of a prospective registry.
CONCLUSION: The findings from this prospective longitudinal registry validate prior observations that dose to submental musculature predicts for increased burden of dysphagia after oropharyngeal IMRT. Findings also support dichotomization of DIGEST grade ≥2 as a dose-dependent split for use as an endpoint in trials or predictive dose-response analysis of videofluoroscopy results. PMID: 29961581 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 28, 2018 Category: Radiology Authors: Kamal M, Mohamed ASR, Volpe S, Zaveri J, Barrow MP, Gunn GB, Lai SY, Ferrarotto R, Lewin JS, Rosenthal DI, Jethanandani A, Meheissen MAM, Mulder SL, Cardenas CE, Fuller CD, Hutcheson KA, MD Anderson Head, Neck Cancer Symptom Working Group Tags: Radiother Oncol Source Type: research

Response to Spartalis et al.
PMID: 29961582 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 28, 2018 Category: Radiology Authors: Jumeau R, Ozsahin M, Moeckli R, Pruvot E, Bourhis J Tags: Radiother Oncol Source Type: research

Adjuvant postoperative high-dose radiotherapy for atypical and malignant meningioma: A phase-II parallel non-randomized and observation study (EORTC 22042-26042).
CONCLUSIONS: These data show that 3-year PFS for WHO grade II meningioma patients undergoing a complete resection (Simpson I-III) is superior to 70% when treated with high-dose (60 Gy) RT. PMID: 29960684 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 27, 2018 Category: Radiology Authors: Weber DC, Ares C, Villa S, Peerdeman SM, Renard L, Baumert BG, Lucas A, Veninga T, Pica A, Jefferies S, Ricardi U, Miralbell R, Stelmes JJ, Liu Y, Collette L, Collette S Tags: Radiother Oncol Source Type: research

Stereotactic radiosurgery and immunotherapy in melanoma brain metastases: Patterns of care and treatment outcomes.
Abstract PURPOSE: Preclinical studies have suggested that radiation therapy (RT) enhances antitumor immune response and can act synergistically when administered with immunotherapy. However, this effect in melanoma brain metastasis is not well studied. We aim to explore the clinical effect of combining RT and immunotherapy in patients with melanoma brain metastasis (MBM). MATERIALS AND METHODS: Patients with MBM between 2011 and 2013 were obtained from the National Cancer Database. Patients who did not have identifiable sites of metastasis and who did not receive RT for the treatment of their MBM were exclude...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 27, 2018 Category: Radiology Authors: Gabani P, Fischer-Valuck BW, Johanns TM, Hernandez-Aya LF, Keller JW, Rich KM, Kim AH, Dunn GP, Robinson CG, Chicoine MR, Huang J, Abraham CD Tags: Radiother Oncol Source Type: research

Parotid gland fat related Magnetic Resonance image biomarkers improve prediction of late radiation-induced xerostomia.
CONCLUSION: Pre-treatment MR-IBMs were associated to radiation-induced xerostomia, which supported the hypothesis that the amount of predisposed fat within the parotid glands is associated with Xer12m. In addition, xerostomia prediction was improved with MR-IBMs compared to the reference model. PMID: 29958772 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 26, 2018 Category: Radiology Authors: van Dijk LV, Thor M, Steenbakkers RJHM, Apte A, Zhai TT, Borra R, Noordzij W, Estilo C, Lee N, Langendijk JA, Deasy JO, Sijtsema NM Tags: Radiother Oncol Source Type: research

A global Unified Dosimetry Index (gUDI) to evaluate simultaneous integrated boost radiotherapy plans in prostate cancer.
CONCLUSION: gUDI score can be a useful tool to quantify treatment plans quality also when volumes with different dose-prescription are treated. PMID: 29945720 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 23, 2018 Category: Radiology Authors: Mambretti M, Romanò C, Marvaso G, Comi S, Cambria R, Ciardo D, Emiro F, Fodor C, Zerini D, Riva G, Petralia G, De Cobelli O, Orecchia R, Cattani F, Jereczek-Fossa BA Tags: Radiother Oncol Source Type: research

Statistical motion modelling for robust evaluation of clinically delivered accumulated dose distributions after curative radiotherapy of locally advanced prostate cancer.
CONCLUSION: The planned dose escalation was not received by more than half-of-the patients. Robustness of the prostate target (CTV67.5) should therefore be better prioritized in these patients given the low toxicity profile. Estimates of delivered dose were less conservative for dose-accumulation due to interaction of random organ motion with the dose matrix. PMID: 29941300 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 22, 2018 Category: Radiology Authors: Hysing LB, Ekanger C, Zolnay Á, Helle SI, Rasi M, Heijmen BJM, Sikora M, Söhn M, Muren LP, Thörnqvist S Tags: Radiother Oncol Source Type: research

Proton therapy for pediatric malignancies: Fact, figures and costs. A joint consensus statement from the pediatric subcommittee of PTCOG, PROS and EPTN.
Abstract Radiotherapy plays an important role in the management of childhood cancer, with the primary aim of achieving the highest likelihood of cure with the lowest risk of radiation-induced morbidity. Proton therapy (PT) provides an undisputable advantage by reducing the radiation 'bath' dose delivered to non-target structures/volume while optimally covering the tumor with tumoricidal dose. This treatment modality comes, however, with an additional costs compared to conventional radiotherapy that could put substantial financial pressure to the health care systems with societal implications. In this review we ass...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 21, 2018 Category: Radiology Authors: Weber DC, Habrand JL, Hoppe BS, Hill Kayser C, Laack NN, Langendijk JA, MacDonald SM, McGovern SL, Pater L, Perentesis JP, Thariat J, Timmerman B, Yock TI, Mahajan A Tags: Radiother Oncol Source Type: research

Harnessing drug/radiation interaction through daily routine practice: Leverage medical and methodological point of view (MORSE 02-17 study).
CONCLUSION: Drug-radiation interaction remains a subject of major interest, not only for conventional anticancer drugs, but also for NACTs. New trial designs are thus required. PMID: 29937210 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 21, 2018 Category: Radiology Authors: Vallard A, Rancoule C, Espenel S, Garcia MA, Langrand-Escure J, He MY, Ben Mrad M, El Meddeb Hamrouni A, Ouni S, Trone JC, Rehailia-Blanchard A, Guillaume E, Vial N, Riocreux C, Guy JB, Magné N Tags: Radiother Oncol Source Type: research

Long term patient reported swallowing function following chemoradiotherapy for oropharyngeal carcinoma.
Abstract BACKGROUND AND PURPOSE: Limited data are available to inform on long term swallowing outcomes following concurrent chemoradiotherapy for oropharyngeal carcinoma. The aims of this study are to determine long term patient-reported swallowing outcomes across two large UK centres in routine clinical practice and identify associated factors. MATERIAL AND METHODS: All patients treated for oropharyngeal squamous cell carcinoma with concurrent chemoradiotherapy, and irradiation of the bilateral neck, between 2011 and 2013 were identified. Those requiring therapeutic enteral feeding prior to treatment, or hav...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 21, 2018 Category: Radiology Authors: Dixon L, Ramasamy S, Cardale K, Dyker K, Garcez K, Lee LW, McPartlin A, Murray P, Sen M, Slevin N, Sykes A, Prestwich R, Thomson D Tags: Radiother Oncol Source Type: research

Survival gain with re-Op/RT for recurred high-grade gliomas depends upon risk groups.
CONCLUSION: Re-RT after re-Op was tolerable with a cumulative median EQD2 of 99.3 Gy and resulted in clear benefit in PFS and marginal gain in OS. Survival gain with re-Op/RT was more prominent in patients with two or more risk factors (age ≥50, WHO pathologic grade IV, unmethylated MGMT promoter), and needs to be validated. PMID: 29937212 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 21, 2018 Category: Radiology Authors: Chun SJ, Park SH, Park CK, Kim JW, Kim TM, Choi SH, Lee ST, Kim IH Tags: Radiother Oncol Source Type: research

Safety concerns regarding ablative radiotherapy for ventricular tachycardia.
PMID: 29937213 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 21, 2018 Category: Radiology Authors: Spartalis M, Spartalis E, Athanasiou A, Nikiteas N Tags: Radiother Oncol Source Type: research

Determinants for local tumour control probability after radiotherapy of anal cancer.
CONCLUSIONS: Our results basically support current guidelines recommending: (1) lower RT dose in small tumours (
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 19, 2018 Category: Radiology Authors: Johnsson A, Leon O, Gunnlaugsson A, Nilsson P, Höglund P Tags: Radiother Oncol Source Type: research

Estimating the need for palliative radiotherapy for non-small cell lung cancer: A criterion-based benchmarking approach.
CONCLUSIONS: Approximately 56% of patients who die of NSCLC in Ontario need PRT, but many are never treated. PMID: 29934108 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 19, 2018 Category: Radiology Authors: Jin CJ, Kong W, Mackillop WJ Tags: Radiother Oncol Source Type: research

Inverse planning and inverse implanting for breast interstitial brachytherapy. Introducing a new anatomy specific breast interstitial template (ASBIT).
Abstract An innovative template, based on thoracic cage surface reconstructions for breast interstitial brachytherapy was developed. Hybrid-inverse-planning-optimisation-based implantations and brachytherapy plans, using three custom anthropomorphic breast phantoms, were utilised for its validation. A user independent, inverse planning and inverse implanting technique is proposed. PMID: 29934109 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 19, 2018 Category: Radiology Authors: Karagiannis E, Leczynski A, Tselis N, Psanis E, Steckenreiter O, Milickovic N, Bon D, Strouthos I, Ferentinos K, Hass P, Gademann G, Baltas D, Zamboglou N Tags: Radiother Oncol Source Type: research

Cardiac mortality in limited-stage small cell lung cancer.
CONCLUSIONS: Although causation between radiotherapy and CSM in LS-SCLC cannot be stated based on these data, we encourage clinical attentiveness to cardiac-sparing radiotherapy for LS-SCLC, along with further investigation evaluating dosimetric correlates for cardiotoxicity. PMID: 29934110 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 19, 2018 Category: Radiology Authors: Verma V, Fakhreddine MH, Haque W, Butler EB, Teh BS, Simone CB Tags: Radiother Oncol Source Type: research

Sensitization of prostate cancer to radiation therapy: Molecules and pathways to target.
This article focuses on the recent findings about molecules and pathways that potentially can be targeted to sensitize prostate cancer cells to ionizing radiation, thereby achieving an improved therapeutic outcome. PMID: 29929859 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 18, 2018 Category: Radiology Authors: Yao M, Rogers L, Suchowerska N, Choe D, Al-Dabbas MA, Narula RS, Lyons JG, Sved P, Li Z, Dong Q Tags: Radiother Oncol Source Type: research

Prospective evaluation of acute toxicity and patient reported outcomes in anal cancer and plan optimization.
CONCLUSIONS: The high incidence of PRO scores and weak agreement to CTCAE suggest that PROs are important tools complementary to CTCAE in evaluating patient symptoms during and after CRT. Proton therapy has the potential to lower radiation doses to most organs at risk. PMID: 29929860 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 18, 2018 Category: Radiology Authors: Kronborg C, Serup-Hansen E, Lefevre A, Wilken EE, Petersen JB, Hansen J, Schouboe A, Nyvang L, Spindler KG Tags: Radiother Oncol Source Type: research

Can clinicopathological parameters predict for lymph node metastases in ypT0-2 rectal carcinoma? Results of the CAO/ARO/AIO-94 and CAO/ARO/AIO-04 phase 3 trials.
CONCLUSION: Advanced ypT-stage, lymphatic invasion and RTD ≥10 mm were prognostic factors for LNM in patients ypT0-2 rectal carcinoma treated with CRT and surgery within both phase 3 trials. The high incidence of LNM in the ypT1-2 group needs to be taken into consideration in the context of oncological safety and indicate that LE should be advocated with great caution in this patient subgroup. The prognostic pathological factor identified here could help guide decision of LE vs TME after standard CRT. PMID: 29929861 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European S...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 18, 2018 Category: Radiology Authors: von den Grün JM, Hartmann A, Fietkau R, Ghadimi M, Liersch T, Hohenberger W, Weitz J, Sauer R, Wittekind C, Ströbel P, Rödel C, Fokas E, German Rectal Cancer Study Group Tags: Radiother Oncol Source Type: research

Changing the global radiation therapy paradigm.
PMID: 29921460 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 16, 2018 Category: Radiology Authors: Pistenmaa DA, Dosanjh M, Amaldi U, Jaffray D, Zubizarreta E, Holt K, Lievens Y, Pipman Y, Coleman CN, Workshop Participants Tags: Radiother Oncol Source Type: research

Clinical feasibility and positional stability of an implanted wired transmitter in a novel electromagnetic positioning system for prostate cancer radiotherapy.
ndblom J Abstract PURPOSE: Three aspects of the RayPilot real-time tracking system were investigated: (1) feasibility of the transmitter with respect to implantation and explantation procedures, (2) user and patients' experiences and (3) quantification of the transmitter positional stability in relation to fiducial markers. METHODS AND MATERIALS: Ten prostate cancer patients scheduled for radiotherapy received transmitter implantation in the prostate, concomitantly with fiducial markers. Transmitter and marker positions were assessed in 3D by orthogonal kV-imaging at daily treatment setup in eight patients. ...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 16, 2018 Category: Radiology Authors: Braide K, Lindencrona U, Welinder K, Götstedt J, Ståhl I, Pettersson N, Kindblom J Tags: Radiother Oncol Source Type: research

Long-term risks of secondary cancer for various whole and partial breast irradiation techniques.
CONCLUSIONS: APBI reduces the risk of secondary cancer 2-4 fold compared to WBI. These techniques are well suited for long-living early stage breast cancer patients. HDR brachytherapy and 3D-conformal APBI achieve mean lung doses between 1 and 1.5 Gy, which could serve as reference. PMID: 29914648 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 15, 2018 Category: Radiology Authors: Hoekstra N, Fleury E, Merino Lara TR, van der Baan P, Bahnerth A, Struik G, Hoogeman M, Pignol JP Tags: Radiother Oncol Source Type: research

Toward A variable RBE for proton beam therapy.
Abstract In the clinic, proton beam therapy (PBT) is based on the use of a generic relative biological effectiveness (RBE) of 1.1 compared to photons in human cancers and normal tissues. However, the experimental basis for this RBE lacks any significant number of representative tumor models and clinically relevant endpoints for dose-limiting organs at risk. It is now increasingly appreciated that much of the variations of treatment responses in cancers are due to inter-tumoral genomic heterogeneity. Indeed, recently it has been shown that defects in certain DNA repair pathways, which are found in subsets of many c...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 14, 2018 Category: Radiology Authors: Willers H, Allen A, Grosshans D, McMahon SJ, von Neubeck C, Wiese C, Vikram B Tags: Radiother Oncol Source Type: research

An overview on personalisation of radiotherapy prescriptions in locally advanced non-small cell lung cancer: Are we there yet?
Abstract Standard of care radiotherapy in LA-NSCLC is 60-66 Gy in 30-33 fractions. However outcomes for these patients are poor with 5-year survival in the range of 10-20%. Randomised controlled trials have shown that dose escalation in a linear fashion does not improve outcomes for all patients, thus there is a need to tailor the prescription to the individual patient. This review assesses the strategies published to personalise the radiation therapy dose prescription in LA-NSCLC. A systematic and scoping search of the literature was performed to identify studies that met the inclusion criteria. 19 relevant stu...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 13, 2018 Category: Radiology Authors: Barrett S, Hanna GG, Marignol L Tags: Radiother Oncol Source Type: research

Hematologic variables associated with brain failure in patients with small-cell lung cancer.
Abstract BACKGROUND AND PURPOSE: We sought factors associated with the development of brain metastases after treatment of small cell lung cancer (SCLC) in patients without brain involvement at diagnosis. METHODS: We analyzed 293 patients with SCLC without brain metastases who received chemotherapy, thoracic radiation therapy (TRT), or both in 2001-2015. Pretreatment hematologic markers (platelet count, neutrophil count, lymphocyte count, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and lactate dehydrogenase) and other clinical characteristics were evaluated for correlation with brain metastas...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 12, 2018 Category: Radiology Authors: Suzuki R, Wei X, Allen PK, Welsh JW, Komaki R, Lin SH Tags: Radiother Oncol Source Type: research

Artificial intelligence in radiation oncology: A specialty-wide disruptive transformation?
Abstract Artificial intelligence (AI) is emerging as a technology with the power to transform established industries, and with applications from automated manufacturing to advertising and facial recognition to fully autonomous transportation. Advances in each of these domains have led some to call AI the "fourth" industrial revolution [1]. In healthcare, AI is emerging as both a productive and disruptive force across many disciplines. This is perhaps most evident in Diagnostic Radiology and Pathology, specialties largely built around the processing and complex interpretation of medical images, where the ...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 12, 2018 Category: Radiology Authors: Thompson RF, Valdes G, Fuller CD, Carpenter CM, Morin O, Aneja S, Lindsay WD, Aerts HJWL, Agrimson B, Deville C, Rosenthal SA, Yu JB, Thomas CR Tags: Radiother Oncol Source Type: research

Response to Alongi et al.
Solberg A PMID: 29907339 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 12, 2018 Category: Radiology Authors: Tøndel H, Lund JÅ, Solberg A Tags: Radiother Oncol Source Type: research

Late toxicity in the randomized multicenter HYPRO trial for prostate cancer analyzed with automated treatment planning.
Abstract PURPOSE/OBJECTIVE: Assess to what extent the use of automated treatment planning would have reduced organ-at-risk dose delivery observed in the randomized HYPRO trial for prostate cancer, and estimate related toxicity reductions. Investigate to what extent improved plan quality for hypofractionation scheme as achieved with automated planning can potentially reduce observed enhanced toxicity for the investigated hypofractionation scheme to levels observed for conventional fractionation scheme. MATERIAL/METHODS: For 725 trial patients, VMAT plans were generated with an algorithm for automated multi-cri...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 6, 2018 Category: Radiology Authors: Sharfo AWM, Dirkx MLP, Bijman RG, Schillemans W, Breedveld S, Aluwini S, Pos F, Incrocci L, Heijmen BJM Tags: Radiother Oncol Source Type: research

Testing criterion-based benchmarking for the appropriate use of radiotherapy.
Abstract INTRODUCTION: Planning for radiotherapy (RT) services requires information on the proportion of patients who should be given radiotherapy. Criterion-Based Benchmark (CBB) has been proposed in Canada to estimate the proportion of cancer patients who should be treated with radiotherapy. The aim of this study was to assess CBB in a health system outside of Canada. METHODS: Radiotherapy data for all new cases of cancer in New South Wales (NSW), and the Australian Capital Territory (ACT) Australia in 2004-06 and were linked to Central Cancer Registry records. Road distances between patient residence and t...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 4, 2018 Category: Radiology Authors: Barton MB, Gabriel GS, Delaney GP Tags: Radiother Oncol Source Type: research

Bowel morbidity following radiochemotherapy and image-guided adaptive brachytherapy for cervical cancer: Physician- and patient reported outcome from the EMBRACE study.
CONCLUSION: Bowel morbidity reported in this large cohort of LACC patients was limited regarding severe/life-threatening events. Mild-moderate diarrhea, flatulence and incontinence were prevalent after treatment with PROs indicating a considerable and clinically relevant burden. Critical knowledge based on the extent and manifestation pattern of treatment-related morbidity will serve future patient management. PMID: 29880222 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 4, 2018 Category: Radiology Authors: Jensen NBK, Pötter R, Kirchheiner K, Fokdal L, Lindegaard JC, Kirisits C, Mazeron R, Mahantshetty U, Jürgenliemk-Schulz IM, Segedin B, Hoskin P, Tanderup K, EMBRACE Collaborative Group Tags: Radiother Oncol Source Type: research

Outcomes of radiosensitisation in elderly patients with advanced bladder cancer.
DISCUSSION: Radiosensitisation is safe and effective and should be considered for fit elderly patients with MIBC. PMID: 29871812 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 2, 2018 Category: Radiology Authors: Christodoulou M, Reeves KJ, Hodgson C, Zeniou A, Slevin F, Kennedy J, Hoskin PJ, Henry A, Choudhury A Tags: Radiother Oncol Source Type: research

Super-resolution T2-weighted 4D MRI for image guided radiotherapy.
Abstract BACKGROUND AND PURPOSE: The superior soft-tissue contrast of 4D-T2w MRI motivates its use for delineation in radiotherapy treatment planning. We address current limitations of slice-selective implementations, including thick slices and artefacts originating from data incompleteness and variable breathing. MATERIALS AND METHODS: A method was developed to calculate midposition and 4D-T2w images of the whole thorax from continuously acquired axial and sagittal 2D-T2w MRI (1.5 × 1.5 × 5.0 mm3). The method employed image-derived respiratory surrogates, deformable image registration a...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 2, 2018 Category: Radiology Authors: Freedman JN, Collins DJ, Gurney-Champion OJ, McClelland JR, Nill S, Oelfke U, Leach MO, Wetscherek A Tags: Radiother Oncol Source Type: research

Potential of memory T cells in bridging preoperative chemoradiation and immunotherapy in rectal cancer.
Abstract The management of locally advanced rectal cancer has passed a long way of developments, where total mesorectal excision and preoperative radiotherapy are crucial to secure clinical outcome. These and other aspects of multidisciplinary strategies are in-depth summarized in the literature, while our mini-review pursues a different goal. From an ethical and medical standpoint, we witness a delayed implementation of novel therapies given the cost/time consuming process of organizing randomized trials that would bridge an already excellent local control in cT3-4 node-positive disease with long-term survival. T...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 2, 2018 Category: Radiology Authors: de Mey S, Jiang H, Wang H, Engels B, Gevaert T, Dufait I, Feron O, Aerts J, Verovski V, De Ridder M Tags: Radiother Oncol Source Type: research

"Radiobiology of Proton Therapy": Results of an international expert workshop.
This report summarizes the main results of the international expert workshop "Radiobiology of Proton Therapy" that was held in November 2016 in Dresden. It addresses the major topics (1) relative biological effectiveness (RBE) in proton beam therapy, (2) interaction of proton radiobiology with radiation physics in current treatment planning, (3) biological effects in proton therapy combined with systemic treatments, and (4) testing biological effects of protons in clinical trials. Finally, important research avenues for improvement of proton radiotherapy based on radiobiological knowledge are identified. The clin...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 31, 2018 Category: Radiology Authors: Lühr A, von Neubeck C, Pawelke J, Seidlitz A, Peitzsch C, Bentzen SM, Bortfeld T, Debus J, Deutsch E, Langendijk JA, Loeffler JS, Mohan R, Scholz M, Sørensen BS, Weber DC, Baumann M, Krause M, “Radiobiology of Proton Therapy” Tags: Radiother Oncol Source Type: research

Retrospective estimation of heart and lung doses in pediatric patients treated with spinal irradiation.
odin NP Abstract BACKGROUND AND PURPOSE: The purpose of this study was to investigate whether treatment information from medical records can be used to estimate radiation doses to heart and lungs retrospectively in pediatric patients receiving spinal irradiation with conventional posterior fields. MATERIAL AND METHODS: An algorithm for retrospective dosimetry in children treated with spinal irradiation was developed in a cohort of 21 pediatric patients with available CT-scans and treatment plans. We developed a multivariable linear regression model with explanatory variables identifiable in case note review f...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 30, 2018 Category: Radiology Authors: Gasic D, Rosenschöld PMA, Vogelius IR, Maraldo MV, Aznar MC, Nysom K, Björk-Eriksson T, Bentzen SM, Brodin NP Tags: Radiother Oncol Source Type: research

Cardiac dose is associated with immunosuppression and poor survival in locally advanced non-small cell lung cancer.
CONCLUSION: RT related immunosuppression is associated with worse patient outcomes, and may represent a source of increased mortality beyond cardiac toxicity alone. PMID: 29859754 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 30, 2018 Category: Radiology Authors: Contreras JA, Lin AJ, Weiner A, Speirs C, Samson P, Mullen D, Campian J, Bradley J, Roach M, Robinson C Tags: Radiother Oncol Source Type: research

Radiotherapy utilization in developing countries: An IAEA study.
CONCLUSIONS: The optimal RTU rate in middle-income countries did not differ significantly from that previously found in high-income countries. The actual RTU rates were consistently lower than the optimal, in particular in countries with limited resources and a large population. PMID: 29859755 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 30, 2018 Category: Radiology Authors: Rosenblatt E, Fidarova E, Zubizarreta EH, Barton MB, Jones GW, Mackillop WJ, Cordero L, Yarney J, Lim G, Gan JV, Cernea V, Stojanovic-Rundic S, Strojan P, Kochbati L, Quarneti A Tags: Radiother Oncol Source Type: research

Delineation guideline for the para-aortic lymph node region in cervical cancer.
PMID: 29807836 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 26, 2018 Category: Radiology Authors: Lee J, Wu MH, Chen YJ Tags: Radiother Oncol Source Type: research

Randomized phase II trial evaluating pain response in patients with spinal metastases following stereotactic body radiotherapy versus three-dimensional conformal radiotherapy.
CONCLUSIONS: This randomized trial demonstrates the utility of palliative SBRT for spinal metastases, which was associated with a quicker and improved pain response. Larger ongoing randomized studies will assist in further addressing these endpoints. PMID: 29843899 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 26, 2018 Category: Radiology Authors: Sprave T, Verma V, Förster R, Schlampp I, Bruckner T, Bostel T, Welte SE, Tonndorf-Martini E, Nicolay NH, Debus J, Rief H Tags: Radiother Oncol Source Type: research

Daily IGRT for prostate cancer: Can we stop the train?
ari B PMID: 29807835 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 25, 2018 Category: Radiology Authors: Alongi F, de Crevoisier R, Corradini S, Créhange G, De Bari B Tags: Radiother Oncol Source Type: research

Evaluation of a magnetic resonance guided linear accelerator for stereotactic radiosurgery treatment.
CONCLUSIONS: Our experience demonstrates that excellent plan quality and delivery accuracy was achievable on the MR-Linac for treating multiple brain metastases with a single isocenter. PMID: 29807837 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 25, 2018 Category: Radiology Authors: Wen N, Kim J, Doemer A, Glide-Hurst C, Chetty IJ, Liu C, Laugeman E, Xhaferllari I, Kumarasiri A, Victoria J, Bellon M, Kalkanis S, Siddiqui MS, Movsas B Tags: Radiother Oncol Source Type: research

Retrospective self-sorted 4D-MRI for the liver.
Abstract PURPOSE: Daily MRI-guidance for liver radiotherapy is becoming possible on an MR-Linac. The purpose of this study was to develop a 4D-MRI strategy using an image-based respiratory signal with an acquisition-reconstruction time
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 24, 2018 Category: Radiology Authors: van de Lindt TN, Fast MF, van der Heide UA, Sonke JJ Tags: Radiother Oncol Source Type: research

Can dose outside the PTV influence the risk of distant metastases in stage I lung cancer patients treated with stereotactic body radiotherapy (SBRT)?
This study included 217 stage I NSCLC patients across 2 institutions who received SBRT. Correlations between clinical and dosimetric factors were investigated. The clinical factors considered were distant metastasis (DM), loco-regional control (LRC) and radiation pneumonitis (RP). The dose (converted to EQD2) delivered to regions of varying size directly outside of the PTV was computed. For each feature, area under the curve (AUC) and odds ratios with respect to the outcome parameters DM, LRC and RP were estimated; Kaplan-Meier (KM) analysis was also performed. RESULTS: Thirty-seven (17%) patients developed DM after a...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 22, 2018 Category: Radiology Authors: Diamant A, Chatterjee A, Faria S, Naqa IE, Bahig H, Filion E, Robinson C, Al-Halabi H, Seuntjens J Tags: Radiother Oncol Source Type: research

Respiratory motion of lymph node stations in pancreatic cancer: Analyses using contrast-enhanced four-dimensional computed tomography.
CONCLUSIONS: We observed significant differences in respiratory motion between the GTV and the LN stations in pancreatic cancer. PMID: 29801722 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 22, 2018 Category: Radiology Authors: Takahashi S, Anada M, Kinoshita T, Shibata T Tags: Radiother Oncol Source Type: research

Outcomes of adjuvant treatments for resectable intrahepatic cholangiocarcinoma: Chemotherapy alone, sequential chemoradiotherapy, or concurrent chemoradiotherapy.
CONCLUSIONS: Adjuvant CCRT improved survival in resected ICC with advanced pathologic stages or a positive margin in early pathologic stages compared with adjuvant CT alone or adjuvant sequential CT and RT. PMID: 29801723 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 22, 2018 Category: Radiology Authors: Lin YK, Hsieh MC, Wang WW, Lin YC, Chang WW, Chang CL, Cheng YF, Wu SY Tags: Radiother Oncol Source Type: research

A radiosensitivity gene signature and PD-L1 predict the clinical outcomes of patients with lower grade glioma in TCGA.
CONCLUSION: We tested the predictive value of a "31-gene signature" and PD-L1 expression status in a dataset of patients with lower grade glioma. Our results suggest that the patient population classified as the PD-L1-high-RR may benefit most from radiotherapy combined with anti-PD-1/PD-L1 treatment. Prospective clinical trial is necessary to validate the findings in a homogenous treated patient cohort. PMID: 29784449 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 18, 2018 Category: Radiology Authors: Jang BS, Kim IA Tags: Radiother Oncol Source Type: research

Physician assessed and patient reported urinary morbidity after radio-chemotherapy and image guided adaptive brachytherapy for locally advanced cervical cancer.
derup K Abstract BACKGROUND AND PURPOSE: The EMBRACE study is a prospective multi-institutional study on MRI guided adaptive brachytherapy (IGABT) in locally advanced cervix cancer (LACC). This analysis describes early to late urinary morbidity assessed by physicians and patients (PRO). MATERIAL AND METHODS: A total of 1176 patients were analysed. Median follow up (FU) was 27 (1-83) months. Morbidity (CTCAE v.3) and PRO (EORTC QLQ-C30&CX24) was prospectively assessed at baseline (BL), and during FU. RESULTS: The most frequent symptoms were frequency/urgency, incontinence, and cystitis with grade 2-...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 18, 2018 Category: Radiology Authors: Fokdal L, Pötter R, Kirchheiner K, Lindegaard JC, Jensen NBK, Kirisits C, Chargari C, Mahantshetty U, Jürgenliemk-Schulz IM, Segedin B, Hoskin P, Tanderup K Tags: Radiother Oncol Source Type: research