Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

A systematic review of circulating predictive and prognostic biomarkers to aid the personalised use of radiotherapy in the radical treatment of patients with oesophageal cancer
CONCLUSIONS: There is consistent evidence for the potential predictive and prognostic value of a small number of biomarkers in OSCC and OAC, though these data are insufficient for translation to current clinical practice. Well-designed prospective studies are now required to validate their role in stratified and personalised RT treatment approaches.PMID:38479442 | DOI:10.1016/j.radonc.2024.110224 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 13, 2024 Category: Radiology Authors: Dylan McClurg Chandan Sanghera Somnath Mukherjee Rebecca C Fitzgerald Christopher M Jones Source Type: research

A population-based analysis of the impact of 1 vs. 2 doses of mitomycin on patterns of failure of anal cancer patients treated with concurrent chemoradiotherapy
CONCLUSIONS: Our analysis showed that 1 vs. 2 cycles of MMC along with 5FU and radiation is associated with comparable treatment outcomes in general. However, in patients with stage IIIb and IIIc cancer, 2 doses of MMC were associated with improved ASCC-SS and distant DFS.PMID:38479443 | DOI:10.1016/j.radonc.2024.110219 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 13, 2024 Category: Radiology Authors: Kurian Joseph Zainab Al Habsi Aswin Abraham Arun Elangovan Sunita Ghosh Truo-Mingh Pham Devika Shreekumar Zeyana Ramji Kim Paulson Keith Tankel Nawaid Usmani Diane Severin Dan Schiller Clarence Wong Karen Mulder Hatim Karachiwala Corinne Doll Karen King T Source Type: research

Dosimetric impact of bone marrow sparing for robustly optimized IMPT for locally advanced cervical cancer
CONCLUSION: Achieving 1 GyRBE BMS for IMPT is feasible for LACC patients with limited dosimetric impact on other OARs. While further bone marrow dose reduction is possible for some patients, it may increase OAR doses substantially for others. Hence, we recommend a personalized approach when introducing BMS into clinical IMPT treatment planning to carefully assess individual patient benefits and risks.PMID:38471634 | DOI:10.1016/j.radonc.2024.110222 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 12, 2024 Category: Radiology Authors: S C Kuipers J Godart A Corbeau S Breedveld J W M Mens S M de Boer R A Nout M S Hoogeman Source Type: research

Optimal hypofractionated radiation therapy schemes for early-stage hepatocellular carcinoma
CONCLUSION: From the fits to the clinical TCP data, we presented the first determination of radiobiological parameters and model-independent optimal fractionation regimens in 1-20 fractions to achieve maximal tumor control whenever safe for SBRT and hypofractionated radiation therapy of early-stage HCC. The determined optimal fractionation schemes agree well with clinical practice for SBRT of early-stage HCC. However, most existing hypofractionated radiation therapy schemes of 3-5 Gy/fraction are not optimal, higher doses are required to maximize tumor control, further validation of these findings is essential with clinica...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 11, 2024 Category: Radiology Authors: Feng Liu Doris R Brown Michael T Munley Source Type: research

Longitudinal changes in the carotid arteries of head and neck cancer patients following radiation therapy: Results from a prospective serial imaging biomarker characterization study
CONCLUSIONS: Functional and morphologic changes of the carotid arteries detected by carotid ultrasound, such as changes in global circumferential strain at 6 months and carotid IMT at 18 months, may be useful for the early detection of radiation-induced carotid artery injury, can guide future research aiming to mitigate carotid artery stenosis, and should be considered for clinical surveillance survivorship recommendations after head and neck RT.PMID:38467343 | DOI:10.1016/j.radonc.2024.110220 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 11, 2024 Category: Radiology Authors: Efstratios Koutroumpakis Abdallah Sherif Radwan Mohamed Peter Chaftari David I Rosenthal Dorothy Gujral Christopher Nutting Serageldin Kamel Mohamed A Naser Peter Kim Roland Bassett Clifton D Fuller Elie Mouhayar MD Anderson Head Neck Radiation Oncology C Source Type: research

Dose-response of localized renal cell carcinoma after stereotactic body radiation therapy: A meta-analysis
CONCLUSIONS: A significant dose response relationship between oncological outcomes and biologically effective dose was not identified, and excellent local control outcomes were observed at the full range of doses. Until new evidence points otherwise, we support current recommendations against routine dose escalation beyond 25-26 Gy in one fraction or 42-48 Gy in three fractions, and to consider de-escalation or compromising target coverage if required to achieve safe organ at risk doses.PMID:38462092 | DOI:10.1016/j.radonc.2024.110216 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 10, 2024 Category: Radiology Authors: Ryan S Huang Ronald Chow Pradnya Chopade Andrew Mihalache Asad Hasan Gabriel Boldt Rachel Glicksman Charles B Simone Michael Lock Srinivas Raman Source Type: research

Very accelerated partial breast irradiation in 1 or 2 days: Late toxicity and early oncological outcome of the GEC-ESTRO VAPBI cohort
CONCLUSIONS: VAPBI based on 1 or ≥2 days of MIBT represents an attractive de-escalation of irradiation approach for low-risk breast cancer. Late toxicity profile appears acceptable while early oncological outcome shows encouraging local control. Longer follow-up is warranted in order to confirm these preliminary results.PMID:38460552 | DOI:10.1016/j.radonc.2024.110217 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 9, 2024 Category: Radiology Authors: Jean-Michel Hannoun-Levi Marta Gimeno Morales Jocelyn Gal Javier Anchuelo Jose-Luis Guinot Miren Gastanaga Norbert Meszaros Csaba Polgar Vratislav Strnad Renaud Schiappa Cristina Gutierrez Source Type: research

Baseline shift corrections towards the heart: External validation of the impact on survival in early-stage NSCLC patients
CONCLUSIONS: In our SBRT cohort, the shifts towards the heart were not associated with worse OS. Moderate correlations were found between tumor and heart baseline shifts in each direction. Moreover, the distance between the PTV and the heart showed a significant correlation with shifts to the heart.PMID:38458257 | DOI:10.1016/j.radonc.2024.110214 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 8, 2024 Category: Radiology Authors: Celia Juan-Cruz Barbara Stam Maddalena Rossi Jose Belderbos Jan-Jakob Sonke Source Type: research

Low-dose radiotherapy synergizes with iRGD-antiCD3-modified T cells by facilitating T cell infiltration
CONCLUSION: Altogether, we demonstrated that low-dose radiotherapy could improve the antitumor potency of iRGD-antiCD3-modified T cells by promoting T cell infiltration, providing a rationale for exploring low-dose radiotherapy in combination of other adoptive T cell therapies in solid tumors.PMID:38458258 | DOI:10.1016/j.radonc.2024.110213 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 8, 2024 Category: Radiology Authors: Shujuan Zhou Mei Zhu Xiao Wei Peiyuan Mu Lijun Shen Yan Wang Juefeng Wan Hui Zhang Fan Xia Zhen Zhang Source Type: research

European association of urology risk stratification predicts outcome in patients receiving PSMA-PET-planned salvage radiotherapy for biochemical recurrence following radical prostatectomy
CONCLUSION: Our data support the EAU risk group definition. EAU risk grouping for BCR reliably predicted outcome in patients staged lymph node-negative after RP and with PSMA-PET before SRT. To our knowledge, this is the first study validating the EAU risk grouping in patients treated with PSMA-PET-planned SRT.PMID:38458259 | DOI:10.1016/j.radonc.2024.110215 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 8, 2024 Category: Radiology Authors: Sophia Scharl Constantinos Zamboglou Iosif Strouthos Andrea Farolfi Francesca Serani Stefan A Koerber J ürgen Debus Jan C Peeken Marco M E Vogel Stephanie G C Kroeze Matthias Guckenberger Manuel Krafcsik George Hruby Louise Emmett Nina-Sophie Schmidt-Heg Source Type: research