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Radiation with concurrent radiosensitizing capecitabine tablets and single-dose mitomycin-C for muscle-invasive bladder cancer: a convenient alternative to 5-fluorouracil.
Abstract BACKGROUND AND PURPOSE: Chemoradiation (CRT) with mitomycin-C (MMC) and 5-fluorouracil (5-FU) has been shown to be superior to radiation alone in patients with muscle-invasive bladder cancer (MIBC). MMC/capecitabine is an effective replacement for 5FU as a radiosensitizer in other malignancies but has not been studied in bladder cancer. We evaluated the outcomes of MIBC patients treated with concurrent radiation and MMC/capecitabine. MATERIALS AND METHODS: MIBC patients treated with CRT (60Gy in 5 weeks with single-dose MMC and capecitabine orally twice daily) between 2014 and 2019 were identified. Acute (
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - August 5, 2020 Category: Radiology Authors: Voskuilen CS, van de Kamp MW, Schuring N, Mertens LS, Noordzij A, Pos F, van Rhijn BWG, van der Heijden MS, Schaake EE Tags: Radiother Oncol Source Type: research

First experience with model-based selection of head and neck cancer patients for proton therapy.
CONCLUSION: Model-based selection of patients with HNC for proton therapy is clinically feasible. Approximately one third of HNC patients qualify for protons and these patients have the highest probability to benefit from protons in terms of toxicity prevention. PMID: 32768508 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - August 5, 2020 Category: Radiology Authors: Tambas M, J H M Steenbakkers R, van der Laan HP, Wolters AM, Kierkels RGJ, Scandurra D, Korevaar EW, Oldehinkel E, van Zon-Meijer TWH, Both S, van den Hoek JGM, Langendijk JA Tags: Radiother Oncol Source Type: research

Evaluation of interplay and organ motion effects by means of 4D dose reconstruction and accumulation.
CONCLUSIONS: 4D dose reconstruction and accumulation enables the clinical estimation of actual exhibited interplay and motion effects. In the patients considered here, the loss of homogeneity caused by interplay and organ motion did not show systematic pattern and smeared out throughout the course of fractionated PBS-PT treatment. Dose degradation due to anatomical changes showed to be more severe and triggered treatment adaptations for five patients. PMID: 32768509 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - August 5, 2020 Category: Radiology Authors: Meijers A, Knopf AC, Crijns APG, Ubbels JF, Niezink AGH, Langendijk JA, Wijsman R, Both S Tags: Radiother Oncol Source Type: research

Intensified Systemic Therapy and Stereotactic Ablative Radiotherapy Dose for Patients with Unresectable Pancreatic Adenocarcinoma.
Abstract PURPOSE: We aimed to report the long-term impact of modern chemotherapy and SABR dose regimens on oncologic outcomes of unresectable pancreatic adenocarcinoma (PA). MATERIALS AND METHODS: We reviewed the treatment characteristics and outcomes of all patients who received multi-fraction SABR for unresectable PA between February 2007 and August 2018 at our institution. Time-to-events were calculated from date of diagnosis treating death as a competing risk. RESULTS: A total of 149 patients were identified. Median follow-up was 15 months (range: 5-47). Median SABR dose was 33 Gy (range: 20-45) deli...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - August 4, 2020 Category: Radiology Authors: Toesca DAS, Ahmed F, Kashyap M, Richelcyn M Baclay J, von Eyben R, Pollom EL, Koong AC, Chang DT Tags: Radiother Oncol Source Type: research

Relationships between rectal and perirectal doses and rectal bleeding or tenesmus in pooled voxel-based analysis of 3 randomised phase III trials.
CONCLUSIONS: The serial response of the rectum with respect to RB has been demonstrated in patients with posteriorly extended lateral beams. Similarly, the parallel response of the PRFS with respect to tenesmus has been demonstrated in patients treated with the posterior beam. PMID: 32745667 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 31, 2020 Category: Radiology Authors: Marcello M, Denham JW, Kennedy A, Haworth A, Steigler A, Greer PB, Holloway LC, Dowling JA, Jameson MG, Roach D, Joseph DJ, Gulliford SL, Dearnaley DP, Sydes MR, Hall E, Ebert MA Tags: Radiother Oncol Source Type: research

Low risk of radiation myelopathy with relaxed spinal cord dose constraints in de novo, single fraction spine stereotactic radiosurgery.
Abstract BACKGROUND AND PURPOSE: Spine stereotactic radiosurgery (SSRS) offers high rates of local control in a critical anatomic area by delivering precise, ablative doses of radiation for treatment of spine metastases. However, the dose tolerance of the spinal cord (SC) after SSRS with relation to radiation myelopathy (RM) is not well-described. MATERIALS AND METHODS: We reviewed patients who underwent single fraction, de novo SSRS from 2012-2017 and received>12 Gy Dmax to the SC, defined using MRI-CT fusion without PRV expansion. The standard SC constraint was D0.01cc ≤12 Gy. Local control was estima...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 31, 2020 Category: Radiology Authors: Diao K, Song J, Thall PF, McGinnis GJ, Boyce-Fappiano D, Amini B, Brown PD, Yeboa DN, Bishop AJ, Li J, Briere TM, Tatsui CE, Rhines LD, Chang EL, Ghia AJ Tags: Radiother Oncol Source Type: research

An especially high rate of radiation pneumonitis observed in patients treated with thoracic radiotherapy and simultaneous osimertinib.
Abstract Our study is the first to report an especially high rate of grade 2 or worse radiation pneumonitis in patients treated with thoracic radiotherapy and simultaneous Osimertinib, despite total lung V5, V20 and MLD seeming unlikely to induce radiation pneumonitis. PMID: 32745669 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 31, 2020 Category: Radiology Authors: Jia W, Guo H, Jing W, Jing X, Li J, Wang M, Yu J, Zhu H Tags: Radiother Oncol Source Type: research

Dose dependent cerebellar atrophy in glioma patients after radio(chemo)therapy.
EGC Abstract BACKGROUND AND PURPOSE: Radiotherapy is a standard treatment option for high-grade gliomas. Brain atrophy has previously been associated with radiotherapy. The goal of this study was to investigate dose dependent cerebellar atrophy using prospective, longitudinal MR data from adult glioma patients who received radiotherapy. MATERIALS AND METHODS: Cerebellar volumes were measured using T1-weighted MR images from 91 glioma patients before radiotherapy (N = 91) and from longitudinal follow-ups acquired in three monthly intervals (N = 349). Relative cerebellar volumes were calculated as ratios to the...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 30, 2020 Category: Radiology Authors: Raschke F, Seidlitz A, Wesemann T, Löck S, Jentsch C, Platzek I, Petr J, van den Hoff J, Kotzerke J, Beuthien-Baumann B, Baumann M, Linn J, Krause M, Troost EGC Tags: Radiother Oncol Source Type: research

Liver-directed combined radiotherapy as a bridge to curative surgery in locally advanced hepatocellular carcinoma beyond the milan criteria.
Abstract BACKGROUND AND PURPOSE: Liver-directed combined radiotherapy (LDCRT) can provide substantial tumor control, which may be an effective bridge to curative surgery for selected patients. We aimed to investigate the outcomes of LDCRT for locally advanced hepatocellular carcinoma (LAHCC) beyond the Milan criteria. MATERIALS AND METHODS: We identified 1078 patients diagnosed with LAHCC who received LDCRT and compared the outcomes based on no surgery, conversion to surgical resection, and liver transplantation (LT). Predictive factors for conversion to curative surgery were identified using logistic regress...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 30, 2020 Category: Radiology Authors: Lee WH, Byun HK, Choi JS, Choi GH, Han DH, Joo DJ, Kim DY, Han KH, Seong J Tags: Radiother Oncol Source Type: research

Changes in gastric anatomy after delivery of breath-hold MR-guided SABR for adrenal metastases.
n S Abstract Delivery of breath-hold MR-guided SABR is time-consuming, and the use of real-time tumor-tracking in a sagittal plane may fail to detect out-of-plane displacements of organs-at-risk. Analysis of daily MR-scans performed pre- and post-SABR revealed frequent decreases in stomach volumes, and in the planned stomach doses. PMID: 32739318 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 30, 2020 Category: Radiology Authors: van Sörnsen de Koste JR, Palacios MA, Chen H, Schneiders FL, Bruynzeel AME, Slotman BJ, Haasbeek CJA, Senan S Tags: Radiother Oncol Source Type: research

Effect of baseline sarcopenia on adjuvant treatment for D2 dissected gastric cancer: Analysis of the ARTIST phase III trial.
CONCLUSIONS: Superior clinical outcomes of adjuvant XP-RT over XP were only observed in patients without preoperative sarcopenia. PMID: 32739319 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 30, 2020 Category: Radiology Authors: Il Yu J, Choi C, Lee J, Kang WK, Park SH, Kim ST, Hong JY, Kim S, Sohn TS, Lee JH, An JY, Choi MG, Bae JM, Kim KM, Han H, Kim K, Nam H, Lim DH Tags: Radiother Oncol Source Type: research

The use of hyaluronic acid hydrogel as a tumour bed marker in breast-conserving therapy.
CONCLUSION: HA hydrogel used as a tumour bed marker improves tumour bed visibility and reduces inter- and intraobserver variability of EBRT boost target volume delineations. PMID: 32738260 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 29, 2020 Category: Radiology Authors: Wiercińska J, Winiecki J, Wronczewska A, Lebioda A, Pławski K, Rhone P, Makarewicz R Tags: Radiother Oncol Source Type: research

Reprint of: Practice recommendations for risk-adapted head and neck cancer radiotherapy during the COVID-19 pandemic: An ASTRO-ESTRO consensus statement.
CONCLUSIONS: This urgent practice recommendation was issued in the knowledge of the very difficult circumstances in which our patients find themselves at present, navigating strained health care systems functioning with limited resources and at heightened risk to their health during the COVID-19 pandemic. The aim of this consensus statement is to ensure high-quality HNC treatments continue, to save lives and for symptomatic benefit. PMID: 32730830 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 27, 2020 Category: Radiology Authors: Thomson DJ, Palma D, Guckenberger M, Balermpas P, Beitler JJ, Blanchard P, Brizel D, Budach W, Caudell J, Corry J, Corvo R, Evans M, Garden AS, Giralt J, Gregoire V, Harari PM, Harrington K, Hitchcock YJ, Johansen J, Kaanders J, Koyfman S, Langendijk JA, Tags: Radiother Oncol Source Type: research

Interpreting clinical significance of machine learning approaches and radiomics in radiation oncology trials.
PMID: 32730831 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 27, 2020 Category: Radiology Authors: Boon IS, Yap MH, Au Yong TPT, Boon CS Tags: Radiother Oncol Source Type: research

Variation in the use of radiotherapy fractionation for breast cancer: Survival outcome and cost implications.
CONCLUSION: Hypofractionation appears underused for breast radiation therapy in NSW over time. This study highlights that evidence-based practice will translate to reduced health care treatment costs. PMID: 32721419 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 25, 2020 Category: Radiology Authors: Batumalai V, Delaney GP, Descallar J, Gabriel G, Wong K, Shafiq J, Barton M Tags: Radiother Oncol Source Type: research

Hospital volume and physician volume in association with survival in patients with nasopharyngeal cancer after radiation therapy.
CONCLUSIONS: NPC patients receiving RT at higher-volume hospitals saw better survival. Treatment for NPC should be centralized to high-volume hospitals rather than high-volume physicians. PMID: 32721420 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 25, 2020 Category: Radiology Authors: Lai TY, Yeh CM, Hu YW, Liu CJ Tags: Radiother Oncol Source Type: research

Re-irradiation in the thorax - An analysis of efficacy and safety based on accumulated EQD2 doses.
CONCLUSION: Even though several organs at risk received maximum accumulated doses of>100 Gy3, thoracic reirradiation resulted in an acceptable toxicity profile. Local tumor control and overall survival remained encouraging even after multiple courses of thoracic radiotherapy. PMID: 32717358 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 24, 2020 Category: Radiology Authors: Schröder C, Stiefel I, Tanadini-Lang S, Pytko I, Vu E, Guckenberger M, Andratschke N Tags: Radiother Oncol Source Type: research

Toxicity in combination immune checkpoint inhibitor and radiation therapy: a systematic review and meta-analysis.
CONCLUSIONS: The random effects model showed comparable grade 3-4 toxicity in using ICI + RT compared to ICI alone in CNS melanoma metastases, NSCLC, and prostate cancer. ICI + RT is safe for future clinical trials in these cancers. PMID: 32717359 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 24, 2020 Category: Radiology Authors: Sha CM, Lehrer EJ, Hwang C, Trifiletti DM, Mackley HB, Drabick JJ, Zaorsky NG Tags: Radiother Oncol Source Type: research

A multimodal treatment of carbon ions irradiation, miRNA-34 and mTOR inhibitor specifically control high-grade chondrosarcoma cancer stem cells.
CONCLUSION: Our results show that particle therapy combined with molecular treatments effectively controls cancer stem cells and may overcome treatment resistance of high-grade chondrosarcoma. PMID: 32717360 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 24, 2020 Category: Radiology Authors: Vares G, Ahire V, Sunada S, Ho Kim E, Sai S, Chevalier F, Romeo PH, Yamamoto T, Nakajima T, Saintigny Y Tags: Radiother Oncol Source Type: research

Is prostate brachytherapy a dying art? Trends and variation in the definitive management of prostate cancer in ontario, canada.
Abstract BACKGROUND AND PURPOSE: Declining prostate brachytherapy utilization has been reported in several studies, despite strong evidence for efficacy and safety compared to alternatives. We sought to evaluate contemporary trends in brachytherapy, external beam radiotherapy (EBRT) and prostatectomy utilization in a publicly funded healthcare system. MATERIALS AND METHODS: Men with localized prostate cancer diagnosed and treated between 2006 and 2017 in Ontario, Canada were identified using administrative data. Men received EBRT, brachytherapy (monotherapy or boost) or prostatectomy as initial definitive man...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 24, 2020 Category: Radiology Authors: Corkum MT, Morton G, Louie AV, Bauman GS, Mendez LC, Chin J, D'Souza DP, Dinniwell RE, Velker VM, Saskin R, Warner A, Rodrigues GB Tags: Radiother Oncol Source Type: research

HPV-positive HNSCC cell lines show strongly enhanced radiosensitivity after photon but not after carbon ion irradiation.
CONCLUSION: While HPV pos. cells are significantly more radiosensitive to photons than HPV neg. cells, no significant difference was seen after 12C-irradiation. This needs to be considered when planning new clinical protocols for the treatment of HPV neg. and pos. tumors with 12C-ions. PMID: 32717362 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 24, 2020 Category: Radiology Authors: Lerch S, Berthold S, Ziemann F, Dreffke K, Subtil FSB, Senger Y, Jensen A, Engenhart-Cabillic R, Dikomey E, Wittig A, Eberle F, Schötz U Tags: Radiother Oncol Source Type: research

Improvement of prediction and classification performance for gamma passing rate by using plan complexity and dosiomics features.
CONCLUSIONS: A combination of both plan and dosiomics features with machine learning technique can improve the prediction and classification performance for GPR. PMID: 32712247 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 23, 2020 Category: Radiology Authors: Hirashima H, Ono T, Nakamura M, Miyabe Y, Mukumoto N, Iramina H, Mizowaki T Tags: Radiother Oncol Source Type: research

Anal Cancer Treatment Regimen Considerations for the COVID-19 Era: In Regard to Tchelebi et al.
PMID: 32710989 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 22, 2020 Category: Radiology Authors: Noticewala SS, Ludmir EB, Eng C, Holliday EB, Minsky BD, Morris VK, Das P Tags: Radiother Oncol Source Type: research

Prognostic factors for overall survival of stage III non-small cell lung cancer patients on computed tomography: a systematic review and meta-analysis.
CONCLUSIONS: Tumor-size and nodal size-related factors are prognostic for OS in stage III NSCLC. Future studies should carefully report study characteristics and contrast factors with guideline recognized factors to improve evidence evaluation and validation. PMID: 32710990 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 22, 2020 Category: Radiology Authors: van Laar M, van Amsterdam WAC, van Lindert ASR, de Jong PA, Verhoeff JJC Tags: Radiother Oncol Source Type: research

A multidimensional cohort study of late toxicity after intensity modulated radiotherapy for sinonasal cancer.
rau C Abstract PURPOSE: To evaluate the occurrence of late toxicity after curatively intended intensity modulated radiotherapy (IMRT) for sinonasal cancer and assess dose-response associations. METHODS: Patients treated with IMRT in 2008-2016 were included. Cross sectional examinations of toxicity from the optic pathway, the brain, the pituitary gland and the nose were performed along with quality of life- (QoL) and dose-response analyses. RESULTS: Twenty-seven patients were enrolled; median age was 67 years (range 47-83). Five patients (19 %) had radiation-related ocular toxicity. The risk of visual acu...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 19, 2020 Category: Radiology Authors: Sharma MB, Jensen K, Urbak SF, Funding M, Johansen J, Bechtold D, Amidi A, Eskildsen SF, Jørgensen JOL, Grau C Tags: Radiother Oncol Source Type: research

Dynamics of cell-free tumour DNA correlate with treatment response of head and neck cancer patients receiving radiochemotherapy.
en K Abstract PURPOSE: Definitive radiochemotherapy (RCTX) with curative intent is one of the standard treatment options in patients with locally advanced head and neck squamous cell carcinoma (HNSCC). Despite this intensive therapy protocol, disease recurrence remains an issue. Therefore, we tested the predictive capacity of liquid biopsies as a novel biomarker during RCTX in patients with HNSCC. MATERIAL AND METHODS: We sequenced the tumour samples of 20 patients with locally advanced HNSCC to identify driver mutations. Subsequently, we performed a longitudinal analysis of circulating tumour DNA (ctDNA) dyn...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 17, 2020 Category: Radiology Authors: Hilke FJ, Muyas F, Admard J, Kootz B, Nann D, Welz S, Rieß O, Zips D, Ossowski S, Schroeder C, Clasen K Tags: Radiother Oncol Source Type: research

Significance of lymphocyte recovery from treatment-related lymphopenia in locally advanced pancreatic cancer.
Abstract BACKGROUND AND PURPOSE: Radiation-induced lymphopenia is associated with poor prognosis in resected pancreatic cancer and locally advanced pancreatic cancer. However, whether lymphocyte recovery contributes to pancreatic cancer prognosis has not been well-investigated. MATERIALS AND METHODS: We evaluated 497 locally advanced pancreatic cancer patients who underwent concurrent chemoradiotherapy (CCRT). Complete blood counts of patients were obtained before, during, and after CCRT until the 12-month follow-up visit. Patients were categorized into 3 groups according to the development of and recovery fr...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 15, 2020 Category: Radiology Authors: Lee BM, Byun HK, Seong J Tags: Radiother Oncol Source Type: research

In response to leung.
PMID: 32681929 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 15, 2020 Category: Radiology Authors: Franco P, Tesio V, Castelli L Tags: Radiother Oncol Source Type: research

Training and validation of a robust PET radiomic-based index to predict distant-relapse-free-survival after radio-chemotherapy for locally advanced pancreatic cancer.
CONCLUSIONS: A radiomic-based index including only two robust PET-RFs predicted DRFS of LAPC patients after radio-chemotherapy. The current results could find relevant applications in the treatment personalization of LAPC. A multi-institution independent validation has been planned. PMID: 32681930 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 15, 2020 Category: Radiology Authors: Mori M, Passoni P, Incerti E, Bettinardi V, Broggi S, Reni M, Whybra P, Spezi E, Vanoli EG, Gianolli L, Picchio M, Di Muzio NG, Fiorino C Tags: Radiother Oncol Source Type: research

Thoracic Radiotherapy As A Risk Factor For Heart Ischemia In Subjects Treated With Chest Irradiation And Chemotherapy And Without Classic Cardiovascular RISK Factors.
Abstract BACKGROUND AND PURPOSE: Radiation Induced Heart Disease (RIHD) represents a late effect of chest irradiation, contributing in increasing mortality rate in oncological patients by affecting pericardium, myocardium, valvs and coronaries. Currently, regarding the risk of Coronary Artery Disease (CAD), a cardiological screening involving exercise stress electrocardiography after 5-10 years from radiotherapy is advised. We sought to determine the rate of ischemia at exercise stress electrocardiography in a population of patients without cardiovascular risk factors who sustained radiotherapy, using a cohort of ...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 14, 2020 Category: Radiology Authors: Vallerio P, Maloberti A, Palazzini M, Occhi L, Peretti A, Nava S, Soriano F, Musca F, DE Chiara B, Belli O, Moreo A, Bisceglia I, Lestuzzi C, Giannattasio C Tags: Radiother Oncol Source Type: research

Outcome and patterns of radiation associated brain image changes after proton therapy for head and neck skull base cancers.
CONCLUSION: Small RAIC lesions after PT occurred in 17.3% of the patients; the majority in nasopharyngeal or sinonasal cancer. The estimated dose-volume correlations confirm the importance of minimizing focal high doses to brain when achievable. PMID: 32679304 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 14, 2020 Category: Radiology Authors: May Engeseth G, Stieb S, Sherif Radwan Mohamed A, He R, Hanquist Stokkevåg C, Brydøy M, Dave Fuller C, Garden AS, I Rosenthal D, Phan J, Morrison WH, Reddy JP, Wu R, Zhang X, Jay Frank S, Brandon Gunn G Tags: Radiother Oncol Source Type: research

Dose-volume effects of breast cancer radiation therapy on the risk of second oesophageal cancer.
CONCLUSION: This first study investigating the relationship between oesophagus dose-volume distribution and oesophageal cancer risk showed an increased risk per Gy for Dmedian with larger volumes irradiated at high doses. While current techniques allows better oesophagus sparing, constraints applied to Dmedian and V30 could potentially further reduce the risk of oesophageal cancer. PMID: 32679305 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 14, 2020 Category: Radiology Authors: Journy N, Schonfeld SJ, Hauptmann M, Roberti S, Howell RM, Smith SA, Vaalavirta L, Stovall M, van Leeuwen FE, Weathers RE, Hodgson D, Gilbert ES, Berrington de Gonzalez A, Morton LM Tags: Radiother Oncol Source Type: research

Intraoperative radiation therapy (IORT) for soft tissue sarcoma - ESTRO IORT Task Force / ACROP recommendations.
CONCLUSIONS: IORT-containing approaches result in high rates of local control with low to acceptable toxicity rates. Based on the available evidence, we made recommendations for the use of IORT in STS. Clinicians and researchers are encouraged to use these guidelines in clinical routine as well as in the design of future trials. PMID: 32679306 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 14, 2020 Category: Radiology Authors: Roeder F, Morillo V, Saleh-Ebrahimi L, Calvo FA, Poortmans P, Ferrer Albiach C Tags: Radiother Oncol Source Type: research

The use of simulation-CT's as acoronavirus disease 2019screening tool during thesevere acute respiratory syndrome coronavirus 2pandemic.
PMID: 32679307 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 14, 2020 Category: Radiology Authors: Nevens D, Billiet C, Weytjens R, Joye I, Machiels M, Vermylen A, Chiari I, Bauwens W, Vemeulen P, Dirix L, Huget P, Verellen D, Dirix P, Meijnders P Tags: Radiother Oncol Source Type: research

A Tumor-Immune Interaction Model for Hepatocellular Carcinoma based on measured Lymphocyte Counts in Patients undergoing Radiotherapy.
CONCLUSIONS: This study introduces a mathematical model for tumor-immune interactions using clinically extracted radiotherapy patient data, which can be applied to design trials aimed at minimizing lymphocyte depleting effects in radiation therapy. PMID: 32679308 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 14, 2020 Category: Radiology Authors: Sung W, Grassberger C, McNamara AL, Basler L, Ehrbar S, Tanadini-Lang S, Hong TS, Paganetti H Tags: Radiother Oncol Source Type: research

Brachytherapy in Belgium in 2018. A national survey of the brachytherapy study group of the Belgian SocieTy for Radiotherapy and Oncology (BeSTRO).
PMID: 32679309 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 14, 2020 Category: Radiology Authors: Salembier C, De Hertogh O, Daisne JF, Palumbo S, Van Gestel D Tags: Radiother Oncol Source Type: research

Prognostic significance of quantitative metastatic lymph node burden on magnetic resonance imaging in nasopharyngeal carcinoma:a retrospective study of 1224 patients from two centers.
CONCLUSIONS: The number of MRI-positive LNs was a predominant independent prognostic factor for NPC patients' survival. It may be incorporated into the future N-staging system to improve its accuracy in predicting outcomes. PMID: 32679310 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 14, 2020 Category: Radiology Authors: Ma H, Liang S, Cui C, Zhang Y, Xie F, Zhou J, Dong A, Chen M, Xie C, Li H, Liu L Tags: Radiother Oncol Source Type: research

The analysis of absorbed dose by pancreas during gastric cancer radiotherapy.
PMID: 32679311 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 14, 2020 Category: Radiology Authors: Polanowski P, Wydmański J, Tukiendorf A, Składowski K Tags: Radiother Oncol Source Type: research

The importance of IL-6 blockade beyond the COVID-19 pandemic: consideration for cancer care.
PMID: 32673773 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 13, 2020 Category: Radiology Authors: Carlo Iorio G, Ricardi U, Franco P Tags: Radiother Oncol Source Type: research

Response to Chai' letter: What caused the difference in prognosis among different physicians?
PMID: 32673774 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 13, 2020 Category: Radiology Authors: Qiu X, Xu T, Li M, Fei Z, Chen C Tags: Radiother Oncol Source Type: research

Response to, "Role of neoadjuvant radiochemotherapy for esophageal cancers over pre/peri-operative chemotherapy in the era of COVID-19 and beyond".
Response to, "Role of neoadjuvant radiochemotherapy for esophageal cancers over pre/peri-operative chemotherapy in the era of COVID-19 and beyond". Radiother Oncol. 2020 Jul 13;: Authors: Tchelebi LT, Goodman K PMID: 32673775 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 13, 2020 Category: Radiology Authors: Tchelebi LT, Goodman K Tags: Radiother Oncol Source Type: research

Role of neoadjuvant radiochemotherapy for esophageal cancers over pre/peri-operative chemotherapy in the era of COVID-19 and beyond.
PMID: 32673776 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 13, 2020 Category: Radiology Authors: Cellini F, Antonietta Gambacorta M, Carlo Mattiucci G, Valentini V Tags: Radiother Oncol Source Type: research

ESTRO ACROP guidelines for Target Volume Definition in the thoracic radiation treatment of Small cell lung cancer.
e U Abstract Radiotherapy (RT) plays a major role in the treatment of small cell lung cancer (SCLC). Therefore, the ACROP committee was asked by ESTRO to provide recommendations on target volume delineation for standard clinical scenarios in definitive (chemo)-radiotherapy (CRT), adjuvant RT for stages I-III SCLC and consolidation thoracic RT for stage IV disease. The aim of these guidelines is to standardise and optimise the process of RT treatment planning for clinical practice and prospective studies. The process for the development of the guidelines included the evaluation of a structured questionnaire followe...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 13, 2020 Category: Radiology Authors: Le Pechoux C, Faivre-Finn C, Ramella S, McDonald F, Manapov F, Martin Putora P, Slotman B, De Ruysscher D, Ricardi U, Geets X, Belderbos J, Pöttgen C, Dziadiuszko R, Peeters S, Lievens Y, Hurkmans C, Van Houtte P, Nestle U Tags: Radiother Oncol Source Type: research

Comment on professional quality of life and burnout amongst radiation oncologists: the impact of alexithymia and empathy.
PMID: 32673778 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 13, 2020 Category: Radiology Authors: Franzcr JL Tags: Radiother Oncol Source Type: research

Management of gynecologic cancer: choosing radiotherapy wisely by 3 Southern Ontario academic centers during the COVID-19 pandemic.
PMID: 32673779 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 13, 2020 Category: Radiology Authors: Han K, Mendez L, D'Souza D, Velker V, Barnes E, Milosevic MF, Fyles A, Ferguson SE, Taggar A, Croke J, Donovan E, Leung E Tags: Radiother Oncol Source Type: research

Letter to the editor regarding the article "Selection of a high-level physician may help improve outcomes of nasopharyngeal carcinoma" by Fei et al.
Letter to the editor regarding the article "Selection of a high-level physician may help improve outcomes of nasopharyngeal carcinoma" by Fei et al. Radiother Oncol. 2020 Jul 13;: Authors: Hong Rim C PMID: 32673780 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 13, 2020 Category: Radiology Authors: Hong Rim C Tags: Radiother Oncol Source Type: research

Clarifications on our review on estimating dose delivery accuracy in stereotactic body radiation therapy: a review of in-vivo measurement methods: in response to the letter of Kos.
PMID: 32663534 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 11, 2020 Category: Radiology Authors: Esposito M, Villaggi E, Bresciani S, Cilla S, Falco MD, Garibaldi C, Russo S, Talamonti C, Stasi M, Mancosu P Tags: Radiother Oncol Source Type: research

Cardiac sub-volume targeting demonstrates regional radiosensitivity in the mouse heart.
Abstract BACKGROUND AND PURPOSE: Radiation-induced cardiac toxicity (RICT) remains one of the most critical dose limiting constraints in radiotherapy. Recent studies have shown higher doses to the base of the heart are associated with worse overall survival in lung cancer patients receiving radiotherapy. This work aimed to investigate the impact of sub-volume heart irradiation in a mouse model using small animal image-guided radiotherapy. MATERIALS AND METHODS: C57BL/6 mice were irradiated with a single fraction of 16 Gy to the base, middle or apex of the heart using a small animal radiotherapy research platf...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 11, 2020 Category: Radiology Authors: Ghita M, Gill EK, Walls GM, Edgar KS, McMahon SJ, Osorio EV, Bergom C, Grieve DJ, Watson CJ, McWilliam A, Aznar M, van Herk M, Williams KJ, Butterworth KT Tags: Radiother Oncol Source Type: research

Impact of a global radiation oncology scholarship for trainees: An evaluation of early outcomes.
We report on early outcomes of a Canadian Global Oncology elective scholarship program for trainees (2014-2019). The number of global oncology electives increased. Academic deliverables and collaborations were observed. There was evidence of personal and professional development. PMID: 32663536 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 11, 2020 Category: Radiology Authors: Vulpe H, Pereira IJ, Bourque JM, Huang F, Adleman J, Rodin D, Kuk J, Goulart J, Chan J, Wakefield D, Hanna TP Tags: Radiother Oncol Source Type: research

Prostate-specific antigen kinetics and biochemical control following stereotactic body radiation therapy, high dose rate brachytherapy, and low dose rate brachytherapy: A multi-institutional analysis of 3,502 patients.
ettig MB, Chang AJ, Jackson WC, Spratt DE, Lehrer E, Zaorsky NG, Kupelian PA, Steinberg ML, Horwitz EM, Jiang NY, Kishan AU Abstract BACKGROUND AND PURPOSE: Stereotactic body radiation therapy (SBRT), low dose rate brachytherapy (LDR-BT) and high dose rate brachytherapy (HDR-BT) are ablative-intent radiotherapy options for prostate cancer (PCa). These vary considerably in dose delivery, which may impact post-treatment prostate-specific antigen (PSA) patterns and biochemical control. We compared PSA kinetics between SBRT, HDR-BT, and LDR-BT, and assessed their relationships to biochemical recurrence-free survival (...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 11, 2020 Category: Radiology Authors: Levin-Epstein R, Cook RR, Wong JK, Stock RG, Jeffrey Demanes D, Collins SP, Aghdam N, Suy S, Mantz C, Katz AJ, Nickols NG, Miszczyk L, Napieralska A, Namysl-Kaletka A, Prionas ND, Bagshaw H, Buyyounouski MK, Cao M, Mahal BA, Shabsovich D, Dang A, Yuan Y, Tags: Radiother Oncol Source Type: research