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Treating patients with Dynamic Wave Arc: First clinical experience.
CONCLUSION: For the first time, DWA has been translated into the clinic and used to treat various treatment sides. DWA has been successfully added to the noncoplanar rotational IMRT techniques arsenal, allowing additional flexibility in dose shaping while preserving dosimetrically robust delivery. PMID: 28117078 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 20, 2017 Category: Radiology Authors: Burghelea M, Verellen D, Dhont J, Hung C, Gevaert T, Van den Begin R, Collen C, Poels K, Tournel K, Boussaer M, Jaudet C, Reynders T, Simon V, de Ridder M Tags: Radiother Oncol Source Type: research

A national dosimetry audit for stereotactic ablative radiotherapy in lung.
CONCLUSIONS: Alanine and film is an effective combination for verifying dosimetric and geometric accuracy. There were some differences across dose algorithms, and geometric accuracy was better for VMAT and CK compared with conformal techniques. The alanine dosimetry results showed that planned and delivered doses were within ±3.0% for 25/27 SABR plans. PMID: 28117079 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 20, 2017 Category: Radiology Authors: Distefano G, Lee J, Jafari S, Gouldstone C, Baker C, Mayles H, Clark CH Tags: Radiother Oncol Source Type: research

Patterns of failure for patients with glioblastoma following O-(2-[(18)F]fluoroethyl)-L-tyrosine PET- and MRI-guided radiotherapy.
Abstract BACKGROUND AND PURPOSE: To evaluate the patterns of failure following clinical introduction of amino-acid O-(2-[(18)F]fluoroethyl)-L-tyrosine (FET)-PET-guided target definition for radiotherapy (RT) of glioblastoma patients. MATERIALS AND METHODS: The first 66 consecutive patients with confirmed histology, scanned using FET-PET/CT and MRI were selected for evaluation. Chemo-radiotherapy was delivered to a volume based on both MRI and FET-PET (PETvol). The volume of recurrence (RV) was defined on MRI data collected at the time of progression according to RANO criteria. RESULTS: Fifty patients wer...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 19, 2017 Category: Radiology Authors: Lundemann M, Costa JC, Law I, Engelholm SA, Muhic A, Poulsen HS, Munck Af Rosenschold P Tags: Radiother Oncol Source Type: research

Dose-effect analysis of radiation induced rib fractures after thoracic SBRT.
CONCLUSIONS: The risk of symptomatic rib fractures after SBRT was significantly correlated to dose, and was
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 19, 2017 Category: Radiology Authors: Stam B, van der Bijl E, Peulen H, Rossi MM, Belderbos JS, Sonke JJ Tags: Radiother Oncol Source Type: research

Cost-effectiveness of prophylactic cranial irradiation with hippocampal avoidance in limited stage small cell lung cancer.
CONCLUSION: This study demonstrates that HA-PCI is more cost-effective than C-PCI in LS-SCLC. Our results support the use of HA-PCI in this patient population, should results from RTOG0933 be confirmed by the ongoing NRGCC003 trial. PMID: 28109544 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 18, 2017 Category: Radiology Authors: Qu XM, Mishra MV, Bauman GS, Slotman B, Mehta M, Gondi V, Louie AV Tags: Radiother Oncol Source Type: research

Brachytherapy for the palliation of dysphagia owing to esophageal cancer: A systematic review and meta-analysis of prospective studies.
CONCLUSION: Brachytherapy is a highly effective and relatively safe treatment option therefore its underuse is no longer justified. Further studies should investigate the optimal radiation dose and number of fractions able to achieve the highest DFS rates. PMID: 28104297 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 16, 2017 Category: Radiology Authors: Fuccio L, Mandolesi D, Farioli A, Hassan C, Frazzoni L, Guido A, de Bortoli N, Cilla S, Pierantoni C, Violante FS, Bazzoli F, Repici A, Morganti AG Tags: Radiother Oncol Source Type: research

Kr üpple-like factor 10 regulates radio-sensitivity of pancreatic cancer via UV radiation resistance-associated gene.
CONCLUSIONS: Klf10 is a potential biomarker in predicting and sensitizing radiation effect in pancreatic cancer. PMID: 28104298 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 16, 2017 Category: Radiology Authors: Chang VH, Tsai YC, Tsai YL, Peng SL, Chen SL, Chang TM, Yu WC, Ch'ang HJ Tags: Radiother Oncol Source Type: research

Liquid fiducial marker applicability in proton therapy of locally advanced lung cancer.
CONCLUSION: The dose perturbations introduced by the LFM were considerably smaller than the solid markers investigated. The RSP of the fiducial marker should be corrected in the treatment planning system to avoid errors. The investigated LFM introduced clinically acceptable dose perturbations for image-guided PBSPT of LALC. PMID: 28104299 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 16, 2017 Category: Radiology Authors: Scherman Rydhög J, Perrin R, Jølck RI, Gagnon-Moisan F, Larsen KR, Clementsen P, Riisgaard de Blanck S, Fredberg Persson G, Weber DC, Lomax T, Andresen TL, Munck Af Rosenschold P Tags: Radiother Oncol Source Type: research

Challenges and opportunities in primary CNS lymphoma: A systematic review.
CONCLUSION: WBRT for consolidation is a well-studied modality; however emerging options to selected population such as HDC-ASCT, dose-reduced WBRT or chemotherapy alone are associated with similar survival outcome and less neurotoxicity in selected series. Ongoing and future clinical trials will better define the best approach on this rare disease. PMID: 28104300 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 16, 2017 Category: Radiology Authors: Kerbauy MN, Moraes FY, Lok BH, Ma J, Kerbauy LN, Spratt DE, Santos FP, Perini GF, Berlin A, Chung C, Hamerschlak N, Yahalom J Tags: Radiother Oncol Source Type: research

Farewell to Prof. Jens Overgaard.
PMID: 28094074 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 13, 2017 Category: Radiology Authors: Baumann M Tags: Radiother Oncol Source Type: research

Efficacy of multiple fraction conventional radiation therapy for painful uncomplicated bone metastases: A systematic review.
CONCLUSION: No major difference exists between the schedules and toxic events studied in these trials. This is consistent with the wealth of randomized data which show no dose response for pain relief after radiotherapy for metastatic bone pain. PMID: 28089482 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 12, 2017 Category: Radiology Authors: Chow R, Hoskin P, Chan S, Mesci A, Hollenberg D, Lam H, DeAngelis C, Chow E Tags: Radiother Oncol Source Type: research

Patterns of failure after radiotherapy for pediatric patients with intracranial ependymoma.
CONCLUSIONS: Local relapse in the tumor bed and the higher dose regions was the predominant pattern of failure. Improving coverage of the target volume and increasing the dose to the high radioresistant regions, taking into consideration other clinical and biological pronostic factors, may be an effective way of reducing local failures. PMID: 28089483 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 12, 2017 Category: Radiology Authors: Tensaouti F, Ducassou A, Chaltiel L, Bolle S, Muracciole X, Coche-Dequeant B, Alapetite C, Bernier V, Claude L, Supiot S, Huchet A, Kerr C, le Prisé E, Laprie A, radiotherapy committee of the French Society for Childhood Cancer (SFCE) Tags: Radiother Oncol Source Type: research

Dosimetric parameters correlate with duodenal histopathologic damage after stereotactic body radiotherapy for pancreatic cancer: Secondary analysis of a prospective clinical trial.
CONCLUSIONS: Duodenal histologic damage correlates with mean duodenal dose, V20-V35, and PTV mean/maximum doses. PMID: 28089484 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 12, 2017 Category: Radiology Authors: Verma V, Lazenby AJ, Zheng D, Bhirud AR, Ly QP, Are C, Sasson AR, Lin C Tags: Radiother Oncol Source Type: research

Development of delineation for the left anterior descending coronary artery region in left breast cancer radiotherapy: An optimized organ at risk.
CONCLUSION: Delineation of the LADR significantly improved contouring similarity and consistency for dose reporting. This could optimize dose estimation for breast radiotherapy. PMID: 28087071 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 10, 2017 Category: Radiology Authors: Lee J, Hua KL, Hsu SM, Lin JB, Lee CH, Lu KW, Dai KY, Huang XN, Huang JZ, Wu MH, Chen YJ Tags: Radiother Oncol Source Type: research

Prophylactic cranial irradiation after definitive chemoradiotherapy for limited-stage small cell lung cancer: Do all patients benefit?
Abstract PURPOSE: Prophylactic cranial irradiation (PCI) can improve overall survival (OS) and suppress brain metastases (BM) in patients with limited-stage small cell lung cancer (LS-SCLC) after complete response to primary therapy. However, PCI can be toxic. We sought to identify characteristics of patients who may not benefit from PCI. METHODS: We identified 658 patients who received chemoradiotherapy at MD Anderson in 1986-2012; 364 received PCI and 294 did not. Median follow-up time was 21.2months (range 1.2-240.8months). Cox proportional hazards regression, competing-risk regression, and Kaplan-Meier an...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 7, 2017 Category: Radiology Authors: Farooqi AS, Holliday EB, Allen PK, Wei X, Cox JD, Komaki R Tags: Radiother Oncol Source Type: research

Robustness of 4D-optimized scanned carbon ion beam therapy against interfractional changes in lung cancer.
CONCLUSION: 4D-optimization appears feasible also under interfractional changes and maintains a dosimetric advantage over less conformal ITV irradiations. Further studies are needed to identify patients benefiting most from the technically more complex 4D-optimization. PMID: 28073579 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 7, 2017 Category: Radiology Authors: Graeff C Tags: Radiother Oncol Source Type: research

Post-WBRT cognitive impairment and hippocampal neuronal depletion measured by in vivo metabolic MR spectroscopy: Results of prospective investigational study.
CONCLUSIONS: Our results suggest hippocampal NAA concentrations decline after WBRT and MRS may be a useful biomarker for monitoring neuronal loss after radiotherapy. PMID: 28063694 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 4, 2017 Category: Radiology Authors: Pospisil P, Kazda T, Hynkova L, Bulik M, Dobiaskova M, Burkon P, Laack NN, Slampa P, Jancalek R Tags: Radiother Oncol Source Type: research

Ipsilateral axillary recurrence after breast conservative surgery: The protective effect of whole breast radiotherapy.
Abstract BACKGROUND AND PURPOSE: Whole breast radiotherapy (WBRT) is one of the possible reasons for the low rate of axillary recurrence after breast-conserving surgery (BCS). PATIENTS AND METHODS: We retrospectively collected data from 4,129 consecutive patients with breast cancer ⩽2cm and negative sentinel lymph node who underwent BCS between 1997 and 2007. We compared the risk of axillary lymph node recurrence between patients treated by WBRT (n=2939) and patients who received partial breast irradiation (PBI; n=1,190) performed by a single dose of electron intraoperative radiotherapy. RESULTS: Media...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 4, 2017 Category: Radiology Authors: Gentilini O, Botteri E, Leonardi MC, Rotmensz N, Vila J, Peradze N, Thomazini MV, Jereczek BA, Galimberti V, Luini A, Veronesi P, Orecchia R Tags: Radiother Oncol Source Type: research

Association of post-treatment positron emission tomography with locoregional control and survival after radiation therapy for squamous cell carcinoma of the vulva.
Abstract BACKGROUND/PURPOSE: The aim of this study was to investigate the use of post-treatment F-18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) for vulvar cancer and compare metabolic response to clinical outcomes. MATERIALS/METHODS: This retrospective study included 21 patients with vulvar squamous cell carcinoma treated with curative-intent radiation between 2007 and 2015. All patients received intensity-modulated radiation treatment (IMRT), a pre-treatment FDG/PET-CT, and a post-treatment FDG-PET/CT performed at a median time of 3months post-IMRT. RESULTS: Media...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 4, 2017 Category: Radiology Authors: Rao YJ, Hassanzadeh C, Chundury A, Hui C, Siegel BA, Dehdashti F, DeWees T, Mullen D, Powell MA, Mutch DG, Schwarz JK, Grigsby PW Tags: Radiother Oncol Source Type: research

Proton beam therapy for olfactory neuroblastoma.
CONCLUSION: PBT was a safe and effective modality for ONB. PMID: 28062086 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 3, 2017 Category: Radiology Authors: Nakamura N, Zenda S, Tahara M, Okano S, Hayashi R, Hojo H, Hotta K, Kito S, Motegi A, Arahira S, Tachibana H, Akimoto T Tags: Radiother Oncol Source Type: research

Does an integrated boost increase acute toxicity in prone hypofractionated breast irradiation? A randomized controlled trial.
CONCLUSIONS: The primary endpoint, moist desquamation, was not significantly different between treatment arms. PMID: 28062087 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 3, 2017 Category: Radiology Authors: Paelinck L, Gulyban A, Lakosi F, Vercauteren T, De Gersem W, Speleers B, Monten C, Mulliez T, Berkovic P, van Greveling A, Decoster F, Coucke P, De Neve W, Veldeman L Tags: Radiother Oncol Source Type: research

Hyperfractionated accelerated reirradiation for rectal cancer: An analysis of outcomes and toxicity.
Abstract BACKGROUND AND PURPOSE: To evaluate outcomes and toxicity in patients treated with hyperfractionated pelvic reirradiation for recurrent rectal cancer. MATERIALS AND METHODS: 102 patients with recurrent rectal adenocarcinoma were treated with pelvic reirradiation with a hyperfractionated accelerated approach, consisting of 1.5Gy twice daily fractions to a total dose of 30-45Gy (median 39Gy), with the most common total dose 39Gy (n=90, 88%). The median dose of prior pelvic radiation therapy (RT) was 50.4Gy (range: 25-63Gy). RESULTS: The median follow-up was 40months for living patients (range, 3-1...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 2, 2017 Category: Radiology Authors: Tao R, Tsai CJ, Jensen G, Eng C, Kopetz S, Overman MJ, Skibber JM, Rodriguez-Bigas M, Chang GJ, You YN, Bednarski BK, Minsky BD, Delclos ME, Koay E, Krishnan S, Crane CH, Das P Tags: Radiother Oncol Source Type: research

GEC-ESTRO/ACROP recommendations for performing bladder-sparing treatment with brachytherapy for muscle-invasive bladder carcinoma.
Abstract The standard treatment for muscle-invasive bladder cancer (MIBC) is a radical cystectomy with pelvic lymph node dissection with or without neoadjuvant chemotherapy. In selected cases a bladder sparing approach is possible, for example a limited surgical excision combined with external beam radiotherapy and brachytherapy. To perform brachytherapy flexible catheters have to be implanted in the bladder wall. The implantation is done either by the open retropubic approach or the endoscopic surgical approach. The largest experience for brachytherapy is with low-dose rate and pulsed-dose rate, although some sho...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 31, 2016 Category: Radiology Authors: Pieters BR, van der Steen-Banasik E, Smits GA, De Brabandere M, Bossi A, Van Limbergen E Tags: Radiother Oncol Source Type: research

Adaptation is mandatory for intensity modulated proton therapy of advanced lung cancer to ensure target coverage.
CONCLUSIONS: Proton therapy for loco-regional lung cancer demands daily imaging and therapy adaptation for a high proportion of patients. PMID: 28043645 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 31, 2016 Category: Radiology Authors: Hoffmann L, Alber M, Jensen MF, Holt MI, Møller DS Tags: Radiother Oncol Source Type: research

Delineating biochemical failure with (68)Ga-PSMA-PET following definitive external beam radiation treatment for prostate cancer.
CONCLUSIONS: PSMA was positive in all patients with BF. Site of failure following dose-escalated EBRT was generally distant. Isolated LR (on PSMA) occurred in only 8 of 419 patients post-EBRT. PMID: 28040309 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 28, 2016 Category: Radiology Authors: Hruby G, Eade T, Kneebone A, Emmett L, Guo L, Ho B, Hsiao E, Schembri G, Hunter J, Kwong C Tags: Radiother Oncol Source Type: research

Risk-adapted simultaneous integrated boost-proton beam therapy (SIB-PBT) for advanced hepatocellular carcinoma with tumour vascular thrombosis.
Abstract PURPOSE: To evaluate clinical effectiveness and safety of simultaneous integrated boost-proton beam therapy (SIB-PBT) in hepatocellular carcinoma (HCC) patients with tumour vascular thrombosis (TVT). MATERIAL AND METHODS: Forty-one HCC patients with TVT underwent SIB-PBT using three dose-fractionation schemes: if gross tumour volume
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 26, 2016 Category: Radiology Authors: Kim DY, Park JW, Kim TH, Kim BH, Moon SH, Kim SS, Woo SM, Koh YH, Lee WJ, Kim CM Tags: Radiother Oncol Source Type: research

Leukocytosis and neutrophilia predicts outcome in anal cancer.
Abstract OBJECTIVE: Leukocytosis and neutrophilia could be the tip of the iceberg in the inflammatory tumor microenvironment. We aimed to validate their prognostic significance in a cohort of patients treated with definitive chemoradiation for anal squamous cell carcinoma (SCC). MATERIALS & METHODS: Clinical records from all consecutive patients treated in a single institution between 2006 and 2016 with curative-intent radiotherapy were retrospectively analyzed. Leukocytosis and neutrophilia, defined as leukocyte or neutrophil count over 10,000 and 7500/mm(3), respectively, were studied in terms of overal...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 23, 2016 Category: Radiology Authors: Schernberg A, Escande A, Rivin Del Campo E, Ducreux M, Nguyen F, Goere D, Chargari C, Deutsch E Tags: Radiother Oncol Source Type: research

Double strand break induction and kinetics indicate preserved hypersensitivity in keratinocytes to subtherapeutic doses for 7weeks of radiotherapy.
CONCLUSIONS: These results represented the first evidence of preserved HRS, assessed by γH2AX- and 53BP1-labelled DSB foci, throughout a 7-week treatment course with daily repeated subtherapeutic dose fractions. PMID: 28017476 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 22, 2016 Category: Radiology Authors: Qvarnström F, Simonsson M, Nyman J, Hermansson I, Book M, Johansson KA, Turesson I Tags: Radiother Oncol Source Type: research

Reply to Alongi et al.
PMID: 28012792 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 21, 2016 Category: Radiology Authors: Nyman J, Hallqvist A Tags: Radiother Oncol Source Type: research

PET imaging of zirconium-89 labelled cetuximab: A phase I trial in patients with head and neck and lung cancer.
CONCLUSIONS: Both presented (89)Zr-cetuximab administration schedules are safe. The recommended dose for future trials is 60MBq, with a minimum time interval for scanning of 6days. PMID: 28012793 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 21, 2016 Category: Radiology Authors: van Loon J, Even AJ, Aerts HJ, Öllers M, Hoebers F, van Elmpt W, Dubois L, Dingemans AC, Lalisang RI, Kempers P, Brans B, Winnepenninckx V, Speel EJ, Thunnissen E, Smits KM, Boellaard R, Vugts DJ, De Ruysscher D, Lambin P Tags: Radiother Oncol Source Type: research

Improved overall survival with adjuvant radiotherapy for high-intermediate and high risk Stage I endometrial cancer.
Abstract BACKGROUND/PURPOSE: To perform a large analysis of Stage I endometrioid-type endometrial cancer patients to determine the impact of adjuvant radiotherapy (ART) on survival. MATERIAL/METHODS: 132,976 FIGO Stage I endometrioid-type endometrial cancer patients treated surgically were identified within the National Cancer Database (NCDB) comprising Commission on Cancer facilities in the United States. Patients were categorized as observation (OBS) or ART (vaginal brachytherapy, external beam radiotherapy, or both). Univariable generalized linear mixed effects models were used to estimate the odds of rece...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 21, 2016 Category: Radiology Authors: Harkenrider MM, Adams W, Block AM, Kliethermes S, Small W, Grover S Tags: Radiother Oncol Source Type: research

Determining the need and utilization of radiotherapy in cancers of the breast, cervical, lung, prostate and rectum: A population level study.
CONCLUSIONS: RT shortfalls exist in the utilization of RT in AB, Canada despite centralized cancer care and a publically funded health care system. Decisions to address shortfalls need to be mindful of how model selection can impact on findings. PMID: 28012795 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 21, 2016 Category: Radiology Authors: Shack L, Lu S, Weeks LA, Craighead P, Kerba M Tags: Radiother Oncol Source Type: research

Stereotactic precision and conventional radiotherapy evaluation (SPACE)-Trial for medically inoperable Stage I NSCLC: A lost opportunity?
PMID: 28010932 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 20, 2016 Category: Radiology Authors: Alongi F, Tebano U, Mazzola R Tags: Radiother Oncol Source Type: research

Phase I study of stereotactic body radiation therapy for peripheral T2N0M0 non-small cell lung cancer (JCOG0702): Results for the group with PTV ⩾100cc.
CONCLUSIONS: The RD was determined to be 50Gy in 4 fractions in this population. PMID: 27993416 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 16, 2016 Category: Radiology Authors: Onimaru R, Onishi H, Shibata T, Hiraoka M, Ishikura S, Karasawa K, Matsuo Y, Kokubo M, Shioyama Y, Matsushita H, Ito Y, Shirato H Tags: Radiother Oncol Source Type: research

Dynamic CT imaging of volumetric changes in pulmonary nodules correlates with physical measurements of stiffness.
CONCLUSION: We demonstrated proof of concept that PN volume changes measured non-invasively correlate with direct physical measurements of stiffness. These results may translate clinically into a means of improving the specificity of CT screening for lung cancer and/or improving individual prognostic assessments based on lung tumor stiffness. PMID: 27989402 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 15, 2016 Category: Radiology Authors: Lartey FM, Rafat M, Negahdar M, Malkovskiy AV, Dong X, Sun X, Li M, Doyle T, Rajadas J, Graves EE, Loo BW, Maxim PG Tags: Radiother Oncol Source Type: research

The relative biological effectiveness of antiprotons.
CONCLUSIONS: This paper reports the final results of the experiment AD-4/ACE at CERN on the first-ever direct measurement of RBE of antiprotons and constitutes the first step toward developing treatment plans. PMID: 27988058 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 14, 2016 Category: Radiology Authors: Holzscheiter MH, Alsner J, Bassler N, Boll R, Caccia M, Knudsen H, Maggiore C, Petersen JB, Sellner S, Straße T, Singers Sørensen B, Overgaard J Tags: Radiother Oncol Source Type: research

Regional variability in radiation-induced lung damage can be predicted by baseline CT numbers.
CONCLUSIONS: Limited amount of damage was observed in LD subvolumes, while the relative density increase of all subvolumes was well predictable. This could allow dose redistribution preferentially targeting low-density lung regions. PMID: 27979369 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 12, 2016 Category: Radiology Authors: Defraene G, van Elmpt W, Crijns W, De Ruysscher D Tags: Radiother Oncol Source Type: research

Optimal design and patient selection for interventional trials using radiogenomic biomarkers: A REQUITE and Radiogenomics consortium statement.
Abstract The optimal design and patient selection for interventional trials in radiogenomics seem trivial at first sight. However, radiogenomics do not give binary information like in e.g. targetable mutation biomarkers. Here, the risk to develop severe side effects is continuous, with increasing incidences of side effects with higher doses and/or volumes. In addition, a multi-SNP assay will produce a predicted probability of developing side effects and will require one or more cut-off thresholds for classifying risk into discrete categories. A classical biomarker trial design is therefore not optimal, whereas a r...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 12, 2016 Category: Radiology Authors: De Ruysscher D, Defraene G, Ramaekers BL, Lambin P, Briers E, Stobart H, Ward T, Bentzen SM, Van Staa T, Azria D, Rosenstein B, Kerns S, West C Tags: Radiother Oncol Source Type: research

Cardiac atlas development and validation for automatic segmentation of cardiac substructures.
CONCLUSIONS: A set of cardiac atlases was created for auto-contouring from noncontrast CT images. The accuracy of auto-contouring for the heart, chambers, and great vessels was validated for potential clinical use. PMID: 27939201 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 8, 2016 Category: Radiology Authors: Zhou R, Liao Z, Pan T, Milgrom SA, Pinnix CC, Shi A, Tang L, Yang J, Liu Y, Gomez D, Nguyen QN, Dabaja BS, Court L, Yang J Tags: Radiother Oncol Source Type: research

G2-checkpoint targeting and radiosensitization of HPV/p16-positive HNSCC cells through the inhibition of Chk1 and Wee1.
CONCLUSIONS: Specific Chk1 inhibitors as well as the combined inhibition of Chk1 and Wee1 radiosensitize HPV-positive HNSCC cells. PMID: 27939202 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 8, 2016 Category: Radiology Authors: Busch CJ, Kröger MS, Jensen J, Kriegs M, Gatzemeier F, Petersen C, Münscher A, Rothkamm K, Rieckmann T Tags: Radiother Oncol Source Type: research

Using the Malthus programme to predict the recruitment of patients to MR-linac research trials in prostate and lung cancer.
In this study, we used evidence-based mathematical modelling to predict the patient cohort for MR-linac to assess its feasibility in a time of austerity. We discuss our results and the implications of evidence-based radiotherapy demand modelling tools such as Malthus on the implementation of new technology and value-based healthcare. PMID: 27939554 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 7, 2016 Category: Radiology Authors: Sanderson B, McWilliam A, Faivre-Finn C, Kirkby NF, Jena R, Mee T, Choudhury A Tags: Radiother Oncol Source Type: research

Dosimetric feasibility of ablative dose escalated focal monotherapy with MRI-guided high-dose-rate (HDR) brachytherapy for prostate cancer.
CONCLUSION: Focal ablative dose-escalated radiation is feasible with the proposed protocol. Prospective studies are warranted to determine the clinical outcomes. PMID: 27916416 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 1, 2016 Category: Radiology Authors: Hosni A, Carlone M, Rink A, Ménard C, Chung P, Berlin A Tags: Radiother Oncol Source Type: research

Comparison of toxicity and outcome in advanced stage non-small cell lung cancer patients treated with intensity-modulated (chemo-)radiotherapy using IMRT or VMAT.
Abstract Retrospective evaluation of 188 advanced stage non-small cell lung cancer patients treated with IMRT or VMAT revealed a limited increase of moderate to severe acute esophageal toxicity after VMAT. Acute pulmonary toxicity and severe late toxicity were low. Overall survival did not differ between the IMRT and VMAT groups. PMID: 27914680 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 30, 2016 Category: Radiology Authors: Wijsman R, Dankers F, Troost EG, Hoffmann AL, van der Heijden EH, de Geus-Oei LF, Bussink J Tags: Radiother Oncol Source Type: research

Prophylactic treatment with a potent corticosteroid cream ameliorates radiodermatitis, independent of radiation schedule: A randomized double blinded study.
Abstract BACKGROUND AND PURPOSE: The study will test the hypothesis that preventive topical steroid treatment instituted from start of radiotherapy can ameliorate acute radiation dermatitis. Subgroups of increased risk of dermatitis are included. MATERIAL AND METHODS: A double blinded randomized trial in patients with breast cancer receiving adjuvant radiotherapy (RT) after surgery. In total, 202 patients were randomized to betamethasone-17-valerate cream or Essex® cream, a moisturizer. Treatment was assessed by RTOG clinical scoring. Patients' symptoms were recorded. The analyses were stratified for RT s...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 29, 2016 Category: Radiology Authors: Ulff E, Maroti M, Serup J, Nilsson M, Falkmer U Tags: Radiother Oncol Source Type: research

Volumetric modulated arc therapy with dynamic collimator rotation for improved multileaf collimator tracking of the prostate.
CONCLUSION: Prostate VMAT plans with rotating collimator were of similar quality as fixed collimator plans, but more suitable for MLC tracking with significantly better agreement between planned and delivered dose distributions. MLC tracking for prostate cancer patients can therefore be improved without the requirement of additional efforts or hardware changes. PMID: 27908453 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 28, 2016 Category: Radiology Authors: Murtaza G, Toftegaard J, Khan EU, Poulsen PR Tags: Radiother Oncol Source Type: research

Reply letter to "Texture analysis of parotid gland as a predictive factor of radiation induced xerostomia: A subset analysis".
Reply letter to "Texture analysis of parotid gland as a predictive factor of radiation induced xerostomia: A subset analysis". Radiother Oncol. 2016 Nov 25;: Authors: van Dijk LV, Langendijk JA, Sijtsema NM, Steenbakkers RJ PMID: 27894600 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 25, 2016 Category: Radiology Authors: van Dijk LV, Langendijk JA, Sijtsema NM, Steenbakkers RJ Tags: Radiother Oncol Source Type: research

The changing landscape in radiotherapy for breast cancer: Lessons from long term follow-up in some European breast cancer trials.
Abstract This review describes the developments in the radiation treatment of breast cancer based on some randomized European trials during the past decades. It will focus on the relevance of long term follow-up in breast cancer patients, starting with the surprising and important change in treatment results during follow-up shown in a locally advanced breast cancer trial. Breast conserving therapy (BCT) in stage I and II breast cancer was explored and tested in a randomized trial to prove equivalence between BCT and mastectomy. The positive outcome led to trials in breast conserving therapy with lower doses and p...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 24, 2016 Category: Radiology Authors: Bartelink H Tags: Radiother Oncol Source Type: research

Patient-reported quality of life after stereotactic body radiation therapy versus moderate hypofractionation for clinically localized prostate cancer.
Abstract BACKGROUND AND PURPOSE: Evaluate changes in bowel, urinary and sexual patient-reported quality of life following treatment with moderately hypofractionated radiotherapy (
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 24, 2016 Category: Radiology Authors: Johnson SB, Soulos PR, Shafman TD, Mantz CA, Dosoretz AP, Ross R, Finkelstein SE, Collins SP, Suy S, Brower JV, Ritter MA, King CR, Kupelian PA, Horwitz EM, Pollack A, Abramowitz MC, Hallman MA, Faria S, Gross CP, Yu JB Tags: Radiother Oncol Source Type: research

Internal and external generalizability of temporal dose-response relationships for xerostomia following IMRT for head and neck cancer.
Abstract BACKGROUND AND PURPOSE: To study internal and external generalizability of temporal dose-response relationships for xerostomia after intensity-modulated radiotherapy (IMRT) for head and neck cancer, and to investigate potential amendments of the QUANTEC guidelines. MATERIAL AND METHODS: Objective xerostomia was assessed in 121 patients (nCohort1=55; nCohort2=66) treated to 70Gy@2Gy in 2006-2015. Univariate and multivariate analyses (UVA, MVA with 1000 bootstrap populations) were conducted in Cohort1, and generalizability of the best-performing MVA model was investigated in Cohort2 (performance: AUC, ...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 24, 2016 Category: Radiology Authors: Thor M, Owosho AA, Clark HD, Oh JH, Riaz N, Hovan A, Tsai J, Thomas SD, Yom SH, Wu JS, Huryn JM, Moiseenko V, Lee NY, Estilo CL, Deasy JO Tags: Radiother Oncol Source Type: research

GEC-ESTRO ACROP recommendations for head & neck brachytherapy in squamous cell carcinomas: 1st update - Improvement by cross sectional imaging based treatment planning and stepping source technology.
GEC-ESTRO ACROP recommendations for head & neck brachytherapy in squamous cell carcinomas: 1st update - Improvement by cross sectional imaging based treatment planning and stepping source technology. Radiother Oncol. 2016 Nov 23;: Authors: Kovács G, Martinez-Monge R, Budrukkar A, Guinot JL, Johansson B, Strnad V, Skowronek J, Rovirosa A, Siebert FA, GEC-ESTRO Head & Neck Working Group Abstract The Head and Neck Working Group of the GEC-ESTRO (Groupe Européen de Curiethérapie - European Society for Therapeutic Radiology and Oncology) published in 2009 the consensus recommen...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 23, 2016 Category: Radiology Authors: Kovács G, Martinez-Monge R, Budrukkar A, Guinot JL, Johansson B, Strnad V, Skowronek J, Rovirosa A, Siebert FA, GEC-ESTRO Head & Neck Working Group Tags: Radiother Oncol Source Type: research