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Can clinicopathological parameters predict for lymph node metastases in ypT0-2 rectal carcinoma? Results of the CAO/ARO/AIO-94 and CAO/ARO/AIO-04 phase 3 trials.
CONCLUSION: Advanced ypT-stage, lymphatic invasion and RTD ≥10 mm were prognostic factors for LNM in patients ypT0-2 rectal carcinoma treated with CRT and surgery within both phase 3 trials. The high incidence of LNM in the ypT1-2 group needs to be taken into consideration in the context of oncological safety and indicate that LE should be advocated with great caution in this patient subgroup. The prognostic pathological factor identified here could help guide decision of LE vs TME after standard CRT. PMID: 29929861 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European S...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 18, 2018 Category: Radiology Authors: von den Grün JM, Hartmann A, Fietkau R, Ghadimi M, Liersch T, Hohenberger W, Weitz J, Sauer R, Wittekind C, Ströbel P, Rödel C, Fokas E, German Rectal Cancer Study Group Tags: Radiother Oncol Source Type: research

Changing the global radiation therapy paradigm.
PMID: 29921460 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 16, 2018 Category: Radiology Authors: Pistenmaa DA, Dosanjh M, Amaldi U, Jaffray D, Zubizarreta E, Holt K, Lievens Y, Pipman Y, Coleman CN, Workshop Participants Tags: Radiother Oncol Source Type: research

Clinical feasibility and positional stability of an implanted wired transmitter in a novel electromagnetic positioning system for prostate cancer radiotherapy.
ndblom J Abstract PURPOSE: Three aspects of the RayPilot real-time tracking system were investigated: (1) feasibility of the transmitter with respect to implantation and explantation procedures, (2) user and patients' experiences and (3) quantification of the transmitter positional stability in relation to fiducial markers. METHODS AND MATERIALS: Ten prostate cancer patients scheduled for radiotherapy received transmitter implantation in the prostate, concomitantly with fiducial markers. Transmitter and marker positions were assessed in 3D by orthogonal kV-imaging at daily treatment setup in eight patients. ...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 16, 2018 Category: Radiology Authors: Braide K, Lindencrona U, Welinder K, Götstedt J, Ståhl I, Pettersson N, Kindblom J Tags: Radiother Oncol Source Type: research

Long-term risks of secondary cancer for various whole and partial breast irradiation techniques.
CONCLUSIONS: APBI reduces the risk of secondary cancer 2-4 fold compared to WBI. These techniques are well suited for long-living early stage breast cancer patients. HDR brachytherapy and 3D-conformal APBI achieve mean lung doses between 1 and 1.5 Gy, which could serve as reference. PMID: 29914648 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 15, 2018 Category: Radiology Authors: Hoekstra N, Fleury E, Merino Lara TR, van der Baan P, Bahnerth A, Struik G, Hoogeman M, Pignol JP Tags: Radiother Oncol Source Type: research

Toward A variable RBE for proton beam therapy.
Abstract In the clinic, proton beam therapy (PBT) is based on the use of a generic relative biological effectiveness (RBE) of 1.1 compared to photons in human cancers and normal tissues. However, the experimental basis for this RBE lacks any significant number of representative tumor models and clinically relevant endpoints for dose-limiting organs at risk. It is now increasingly appreciated that much of the variations of treatment responses in cancers are due to inter-tumoral genomic heterogeneity. Indeed, recently it has been shown that defects in certain DNA repair pathways, which are found in subsets of many c...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 14, 2018 Category: Radiology Authors: Willers H, Allen A, Grosshans D, McMahon SJ, von Neubeck C, Wiese C, Vikram B Tags: Radiother Oncol Source Type: research

An overview on personalisation of radiotherapy prescriptions in locally advanced non-small cell lung cancer: Are we there yet?
Abstract Standard of care radiotherapy in LA-NSCLC is 60-66 Gy in 30-33 fractions. However outcomes for these patients are poor with 5-year survival in the range of 10-20%. Randomised controlled trials have shown that dose escalation in a linear fashion does not improve outcomes for all patients, thus there is a need to tailor the prescription to the individual patient. This review assesses the strategies published to personalise the radiation therapy dose prescription in LA-NSCLC. A systematic and scoping search of the literature was performed to identify studies that met the inclusion criteria. 19 relevant stu...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 13, 2018 Category: Radiology Authors: Barrett S, Hanna GG, Marignol L Tags: Radiother Oncol Source Type: research

Hematologic variables associated with brain failure in patients with small-cell lung cancer.
Abstract BACKGROUND AND PURPOSE: We sought factors associated with the development of brain metastases after treatment of small cell lung cancer (SCLC) in patients without brain involvement at diagnosis. METHODS: We analyzed 293 patients with SCLC without brain metastases who received chemotherapy, thoracic radiation therapy (TRT), or both in 2001-2015. Pretreatment hematologic markers (platelet count, neutrophil count, lymphocyte count, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and lactate dehydrogenase) and other clinical characteristics were evaluated for correlation with brain metastas...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 12, 2018 Category: Radiology Authors: Suzuki R, Wei X, Allen PK, Welsh JW, Komaki R, Lin SH Tags: Radiother Oncol Source Type: research

Artificial intelligence in radiation oncology: A specialty-wide disruptive transformation?
Abstract Artificial intelligence (AI) is emerging as a technology with the power to transform established industries, and with applications from automated manufacturing to advertising and facial recognition to fully autonomous transportation. Advances in each of these domains have led some to call AI the "fourth" industrial revolution [1]. In healthcare, AI is emerging as both a productive and disruptive force across many disciplines. This is perhaps most evident in Diagnostic Radiology and Pathology, specialties largely built around the processing and complex interpretation of medical images, where the ...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 12, 2018 Category: Radiology Authors: Thompson RF, Valdes G, Fuller CD, Carpenter CM, Morin O, Aneja S, Lindsay WD, Aerts HJWL, Agrimson B, Deville C, Rosenthal SA, Yu JB, Thomas CR Tags: Radiother Oncol Source Type: research

Response to Alongi et al.
Solberg A PMID: 29907339 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 12, 2018 Category: Radiology Authors: Tøndel H, Lund JÅ, Solberg A Tags: Radiother Oncol Source Type: research

Late toxicity in the randomized multicenter HYPRO trial for prostate cancer analyzed with automated treatment planning.
Abstract PURPOSE/OBJECTIVE: Assess to what extent the use of automated treatment planning would have reduced organ-at-risk dose delivery observed in the randomized HYPRO trial for prostate cancer, and estimate related toxicity reductions. Investigate to what extent improved plan quality for hypofractionation scheme as achieved with automated planning can potentially reduce observed enhanced toxicity for the investigated hypofractionation scheme to levels observed for conventional fractionation scheme. MATERIAL/METHODS: For 725 trial patients, VMAT plans were generated with an algorithm for automated multi-cri...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 6, 2018 Category: Radiology Authors: Sharfo AWM, Dirkx MLP, Bijman RG, Schillemans W, Breedveld S, Aluwini S, Pos F, Incrocci L, Heijmen BJM Tags: Radiother Oncol Source Type: research

Testing criterion-based benchmarking for the appropriate use of radiotherapy.
Abstract INTRODUCTION: Planning for radiotherapy (RT) services requires information on the proportion of patients who should be given radiotherapy. Criterion-Based Benchmark (CBB) has been proposed in Canada to estimate the proportion of cancer patients who should be treated with radiotherapy. The aim of this study was to assess CBB in a health system outside of Canada. METHODS: Radiotherapy data for all new cases of cancer in New South Wales (NSW), and the Australian Capital Territory (ACT) Australia in 2004-06 and were linked to Central Cancer Registry records. Road distances between patient residence and t...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 4, 2018 Category: Radiology Authors: Barton MB, Gabriel GS, Delaney GP Tags: Radiother Oncol Source Type: research

Bowel morbidity following radiochemotherapy and image-guided adaptive brachytherapy for cervical cancer: Physician- and patient reported outcome from the EMBRACE study.
CONCLUSION: Bowel morbidity reported in this large cohort of LACC patients was limited regarding severe/life-threatening events. Mild-moderate diarrhea, flatulence and incontinence were prevalent after treatment with PROs indicating a considerable and clinically relevant burden. Critical knowledge based on the extent and manifestation pattern of treatment-related morbidity will serve future patient management. PMID: 29880222 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 4, 2018 Category: Radiology Authors: Jensen NBK, Pötter R, Kirchheiner K, Fokdal L, Lindegaard JC, Kirisits C, Mazeron R, Mahantshetty U, Jürgenliemk-Schulz IM, Segedin B, Hoskin P, Tanderup K, EMBRACE Collaborative Group Tags: Radiother Oncol Source Type: research

Outcomes of radiosensitisation in elderly patients with advanced bladder cancer.
DISCUSSION: Radiosensitisation is safe and effective and should be considered for fit elderly patients with MIBC. PMID: 29871812 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 2, 2018 Category: Radiology Authors: Christodoulou M, Reeves KJ, Hodgson C, Zeniou A, Slevin F, Kennedy J, Hoskin PJ, Henry A, Choudhury A Tags: Radiother Oncol Source Type: research

Super-resolution T2-weighted 4D MRI for image guided radiotherapy.
Abstract BACKGROUND AND PURPOSE: The superior soft-tissue contrast of 4D-T2w MRI motivates its use for delineation in radiotherapy treatment planning. We address current limitations of slice-selective implementations, including thick slices and artefacts originating from data incompleteness and variable breathing. MATERIALS AND METHODS: A method was developed to calculate midposition and 4D-T2w images of the whole thorax from continuously acquired axial and sagittal 2D-T2w MRI (1.5 × 1.5 × 5.0 mm3). The method employed image-derived respiratory surrogates, deformable image registration a...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 2, 2018 Category: Radiology Authors: Freedman JN, Collins DJ, Gurney-Champion OJ, McClelland JR, Nill S, Oelfke U, Leach MO, Wetscherek A Tags: Radiother Oncol Source Type: research

Potential of memory T cells in bridging preoperative chemoradiation and immunotherapy in rectal cancer.
Abstract The management of locally advanced rectal cancer has passed a long way of developments, where total mesorectal excision and preoperative radiotherapy are crucial to secure clinical outcome. These and other aspects of multidisciplinary strategies are in-depth summarized in the literature, while our mini-review pursues a different goal. From an ethical and medical standpoint, we witness a delayed implementation of novel therapies given the cost/time consuming process of organizing randomized trials that would bridge an already excellent local control in cT3-4 node-positive disease with long-term survival. T...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 2, 2018 Category: Radiology Authors: de Mey S, Jiang H, Wang H, Engels B, Gevaert T, Dufait I, Feron O, Aerts J, Verovski V, De Ridder M Tags: Radiother Oncol Source Type: research

"Radiobiology of Proton Therapy": Results of an international expert workshop.
This report summarizes the main results of the international expert workshop "Radiobiology of Proton Therapy" that was held in November 2016 in Dresden. It addresses the major topics (1) relative biological effectiveness (RBE) in proton beam therapy, (2) interaction of proton radiobiology with radiation physics in current treatment planning, (3) biological effects in proton therapy combined with systemic treatments, and (4) testing biological effects of protons in clinical trials. Finally, important research avenues for improvement of proton radiotherapy based on radiobiological knowledge are identified. The clin...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 31, 2018 Category: Radiology Authors: Lühr A, von Neubeck C, Pawelke J, Seidlitz A, Peitzsch C, Bentzen SM, Bortfeld T, Debus J, Deutsch E, Langendijk JA, Loeffler JS, Mohan R, Scholz M, Sørensen BS, Weber DC, Baumann M, Krause M, “Radiobiology of Proton Therapy” Tags: Radiother Oncol Source Type: research

Retrospective estimation of heart and lung doses in pediatric patients treated with spinal irradiation.
odin NP Abstract BACKGROUND AND PURPOSE: The purpose of this study was to investigate whether treatment information from medical records can be used to estimate radiation doses to heart and lungs retrospectively in pediatric patients receiving spinal irradiation with conventional posterior fields. MATERIAL AND METHODS: An algorithm for retrospective dosimetry in children treated with spinal irradiation was developed in a cohort of 21 pediatric patients with available CT-scans and treatment plans. We developed a multivariable linear regression model with explanatory variables identifiable in case note review f...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 30, 2018 Category: Radiology Authors: Gasic D, Rosenschöld PMA, Vogelius IR, Maraldo MV, Aznar MC, Nysom K, Björk-Eriksson T, Bentzen SM, Brodin NP Tags: Radiother Oncol Source Type: research

Cardiac dose is associated with immunosuppression and poor survival in locally advanced non-small cell lung cancer.
CONCLUSION: RT related immunosuppression is associated with worse patient outcomes, and may represent a source of increased mortality beyond cardiac toxicity alone. PMID: 29859754 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 30, 2018 Category: Radiology Authors: Contreras JA, Lin AJ, Weiner A, Speirs C, Samson P, Mullen D, Campian J, Bradley J, Roach M, Robinson C Tags: Radiother Oncol Source Type: research

Radiotherapy utilization in developing countries: An IAEA study.
CONCLUSIONS: The optimal RTU rate in middle-income countries did not differ significantly from that previously found in high-income countries. The actual RTU rates were consistently lower than the optimal, in particular in countries with limited resources and a large population. PMID: 29859755 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 30, 2018 Category: Radiology Authors: Rosenblatt E, Fidarova E, Zubizarreta EH, Barton MB, Jones GW, Mackillop WJ, Cordero L, Yarney J, Lim G, Gan JV, Cernea V, Stojanovic-Rundic S, Strojan P, Kochbati L, Quarneti A Tags: Radiother Oncol Source Type: research

Delineation guideline for the para-aortic lymph node region in cervical cancer.
PMID: 29807836 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 26, 2018 Category: Radiology Authors: Lee J, Wu MH, Chen YJ Tags: Radiother Oncol Source Type: research

Randomized phase II trial evaluating pain response in patients with spinal metastases following stereotactic body radiotherapy versus three-dimensional conformal radiotherapy.
CONCLUSIONS: This randomized trial demonstrates the utility of palliative SBRT for spinal metastases, which was associated with a quicker and improved pain response. Larger ongoing randomized studies will assist in further addressing these endpoints. PMID: 29843899 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 26, 2018 Category: Radiology Authors: Sprave T, Verma V, Förster R, Schlampp I, Bruckner T, Bostel T, Welte SE, Tonndorf-Martini E, Nicolay NH, Debus J, Rief H Tags: Radiother Oncol Source Type: research

Daily IGRT for prostate cancer: Can we stop the train?
ari B PMID: 29807835 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 25, 2018 Category: Radiology Authors: Alongi F, de Crevoisier R, Corradini S, Créhange G, De Bari B Tags: Radiother Oncol Source Type: research

Evaluation of a magnetic resonance guided linear accelerator for stereotactic radiosurgery treatment.
CONCLUSIONS: Our experience demonstrates that excellent plan quality and delivery accuracy was achievable on the MR-Linac for treating multiple brain metastases with a single isocenter. PMID: 29807837 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 25, 2018 Category: Radiology Authors: Wen N, Kim J, Doemer A, Glide-Hurst C, Chetty IJ, Liu C, Laugeman E, Xhaferllari I, Kumarasiri A, Victoria J, Bellon M, Kalkanis S, Siddiqui MS, Movsas B Tags: Radiother Oncol Source Type: research

Retrospective self-sorted 4D-MRI for the liver.
Abstract PURPOSE: Daily MRI-guidance for liver radiotherapy is becoming possible on an MR-Linac. The purpose of this study was to develop a 4D-MRI strategy using an image-based respiratory signal with an acquisition-reconstruction time
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 24, 2018 Category: Radiology Authors: van de Lindt TN, Fast MF, van der Heide UA, Sonke JJ Tags: Radiother Oncol Source Type: research

Can dose outside the PTV influence the risk of distant metastases in stage I lung cancer patients treated with stereotactic body radiotherapy (SBRT)?
This study included 217 stage I NSCLC patients across 2 institutions who received SBRT. Correlations between clinical and dosimetric factors were investigated. The clinical factors considered were distant metastasis (DM), loco-regional control (LRC) and radiation pneumonitis (RP). The dose (converted to EQD2) delivered to regions of varying size directly outside of the PTV was computed. For each feature, area under the curve (AUC) and odds ratios with respect to the outcome parameters DM, LRC and RP were estimated; Kaplan-Meier (KM) analysis was also performed. RESULTS: Thirty-seven (17%) patients developed DM after a...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 22, 2018 Category: Radiology Authors: Diamant A, Chatterjee A, Faria S, Naqa IE, Bahig H, Filion E, Robinson C, Al-Halabi H, Seuntjens J Tags: Radiother Oncol Source Type: research

Respiratory motion of lymph node stations in pancreatic cancer: Analyses using contrast-enhanced four-dimensional computed tomography.
CONCLUSIONS: We observed significant differences in respiratory motion between the GTV and the LN stations in pancreatic cancer. PMID: 29801722 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 22, 2018 Category: Radiology Authors: Takahashi S, Anada M, Kinoshita T, Shibata T Tags: Radiother Oncol Source Type: research

Outcomes of adjuvant treatments for resectable intrahepatic cholangiocarcinoma: Chemotherapy alone, sequential chemoradiotherapy, or concurrent chemoradiotherapy.
CONCLUSIONS: Adjuvant CCRT improved survival in resected ICC with advanced pathologic stages or a positive margin in early pathologic stages compared with adjuvant CT alone or adjuvant sequential CT and RT. PMID: 29801723 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 22, 2018 Category: Radiology Authors: Lin YK, Hsieh MC, Wang WW, Lin YC, Chang WW, Chang CL, Cheng YF, Wu SY Tags: Radiother Oncol Source Type: research

A radiosensitivity gene signature and PD-L1 predict the clinical outcomes of patients with lower grade glioma in TCGA.
CONCLUSION: We tested the predictive value of a "31-gene signature" and PD-L1 expression status in a dataset of patients with lower grade glioma. Our results suggest that the patient population classified as the PD-L1-high-RR may benefit most from radiotherapy combined with anti-PD-1/PD-L1 treatment. Prospective clinical trial is necessary to validate the findings in a homogenous treated patient cohort. PMID: 29784449 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 18, 2018 Category: Radiology Authors: Jang BS, Kim IA Tags: Radiother Oncol Source Type: research

Physician assessed and patient reported urinary morbidity after radio-chemotherapy and image guided adaptive brachytherapy for locally advanced cervical cancer.
derup K Abstract BACKGROUND AND PURPOSE: The EMBRACE study is a prospective multi-institutional study on MRI guided adaptive brachytherapy (IGABT) in locally advanced cervix cancer (LACC). This analysis describes early to late urinary morbidity assessed by physicians and patients (PRO). MATERIAL AND METHODS: A total of 1176 patients were analysed. Median follow up (FU) was 27 (1-83) months. Morbidity (CTCAE v.3) and PRO (EORTC QLQ-C30&CX24) was prospectively assessed at baseline (BL), and during FU. RESULTS: The most frequent symptoms were frequency/urgency, incontinence, and cystitis with grade 2-...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 18, 2018 Category: Radiology Authors: Fokdal L, Pötter R, Kirchheiner K, Lindegaard JC, Jensen NBK, Kirisits C, Chargari C, Mahantshetty U, Jürgenliemk-Schulz IM, Segedin B, Hoskin P, Tanderup K Tags: Radiother Oncol Source Type: research

Randomized trial comparing two methods of re-irradiation after salvage surgery in head and neck squamous cell carcinoma: Once daily split-course radiotherapy with concomitant chemotherapy or twice daily radiotherapy with cetuximab.
The objective of this randomized trial was to compare two methods of re-irradiation in terms of toxicity and survival. PATIENTS AND METHODS: Patients with recurrence/second primary in previously irradiated area were randomly allocated to receive either 60 Gy over 11 weeks with concomitant 5FU - hydroxyurea (VP-arm), or 60 Gy (1.2 Gy twice daily) over 5 weeks with cetuximab (HFR-arm). Primary endpoint was treatment interruption>15 days (acute toxicity). RESULTS: Twenty-six patients were included in VP-arm and 27 in HFR-arm. One patient in VP-arm experienced>15 days interruption due to toxicity,...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 18, 2018 Category: Radiology Authors: Tao Y, Faivre L, Laprie A, Boisselier P, Ferron C, Jung GM, Racadot S, Gery B, Even C, Breuskin I, Bourhis J, Janot F Tags: Radiother Oncol Source Type: research

Regulation of the oxidative balance with coenzyme Q10 sensitizes human glioblastoma cells to radiation and temozolomide.
CONCLUSIONS: CoQ acts as sensitizer for cytotoxic therapies, disarming GBM cells, but not normal astrocytes, against further pro-oxidant injuries, being potentially useful in clinical practice for this fatal pathology. PMID: 29784452 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 18, 2018 Category: Radiology Authors: Frontiñán-Rubio J, Santiago-Mora RM, Nieva-Velasco CM, Ferrín G, Martínez-González A, Gómez MV, Moreno M, Ariza J, Lozano E, Arjona-Gutiérrez J, Gil-Agudo A, De la Mata M, Pesic M, Peinado JR, Villalba JM, Pérez-Romasanta L, Pérez-García VM, Alc Tags: Radiother Oncol Source Type: research

Tracking tumor biology with radiomics: A systematic review utilizing a radiomics quality score.
In this study, we performed a systematic literature search linking radiomics to tumor biology. All but two studies (n = 39) revealed that radiomic features derived from ultrasound, CT, PET and/or MR are significantly associated with one or several specific tumor biologic substrates, from somatic mutation status to tumor histopathologic grading and metabolism. Considerable inter-observer differences were found with regard to RQS scoring, while important questions were raised concerning the interpretability of the outcome of such scores. PMID: 29779918 [PubMed - as supplied by publisher] (Source: Radiotherapy and On...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 18, 2018 Category: Radiology Authors: Sanduleanu S, Woodruff HC, de Jong EEC, van Timmeren JE, Jochems A, Dubois L, Lambin P Tags: Radiother Oncol Source Type: research

Radiation dose constraints for organs at risk in neuro-oncology; the European Particle Therapy Network consensus.
CONCLUSION: The use of the European Particle Therapy Network-consensus OAR dose constraints summarized in this article is recommended for the model-based approach comparing photon and proton beam irradiation as well as for prospective clinical trials including novel radiation techniques and/or modalities. PMID: 29779919 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 17, 2018 Category: Radiology Authors: Lambrecht M, Eekers DBP, Alapetite C, Burnet NG, Calugaru V, Coremans IEM, Fossati P, Høyer M, Langendijk JA, Romero AM, Paulsen F, Perpar A, Renard L, de Ruysscher D, Timmermann B, Vitek P, Weber DC, van der Weide HL, Whitfield GA, Wiggenraad R, Roelofs Tags: Radiother Oncol Source Type: research

Preoperative radiotherapy or chemoradiotherapy in rectal cancer - Is survival improved? An update of the "Nordic" LARC study in non-resectable cancers.
Preoperative radiotherapy or chemoradiotherapy in rectal cancer - Is survival improved? An update of the "Nordic" LARC study in non-resectable cancers. Radiother Oncol. 2018 May 16;: Authors: Brændengen M, Glimelius B Abstract The randomized "Nordic" LARC study compared preoperative long-course radiotherapy alone (RT) or with chemotherapy (CRT) in the most locally advanced/ugly rectal cancers. Despite significantly better local control in the CRT group, no overall survival benefit was seen after 10 years follow-up. The relations between local control and survival are discus...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 16, 2018 Category: Radiology Authors: Brændengen M, Glimelius B Tags: Radiother Oncol Source Type: research

Risk factors for near-miss events and safety incidents in pediatric radiation therapy.
CONCLUSIONS: Variances in children occurred in early treatment phases, but were detected at later workflow stages. Quality measures should be implemented during early treatment phases with a focus on younger children and those cared for by cross-covering physicians. PMID: 29776675 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 15, 2018 Category: Radiology Authors: Baig N, Wang J, Elnahal S, McNutt T, Wright J, DeWeese T, Terezakis S Tags: Radiother Oncol Source Type: research

Treatment-related toxicity in men who received Intensity-modulated versus 3D-conformal radiotherapy after radical prostatectomy: A national population-based study.
CONCLUSIONS: The use of post-prostatectomy IMRT compared to 3D-CRT is not associated with a statistically significant reduction in rates of severe GU and GI toxicity, although there is some evidence that GU toxicity is lower with IMRT. We would caution against rapid transition to post-prostatectomy IMRT until further evidence is available supporting its superiority. PMID: 29773442 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 14, 2018 Category: Radiology Authors: Sujenthiran A, Nossiter J, Parry M, Charman SC, Cathcart PJ, van der Meulen J, Clarke NW, Payne H, Aggarwal A Tags: Radiother Oncol Source Type: research

Combined high dose rate brachytherapy and external beam radiotherapy for clinically localised prostate cancer.
CONCLUSION: HDR-BRT with supplemental EBRT results in low biochemical relapse-free survival rates associated with a very low incidence of higher-grade late adverse events. PMID: 29764692 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 12, 2018 Category: Radiology Authors: Strouthos I, Chatzikonstantinou G, Zamboglou N, Milickovic N, Papaioannou S, Bon D, Zamboglou C, Rödel C, Baltas D, Tselis N Tags: Radiother Oncol Source Type: research

SBRT for pancreatic cancer: In regard of Bohoudi et al.
PMID: 29759683 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 11, 2018 Category: Radiology Authors: Bohoudi O, Bruynzeel AM, Senan S, Cuijpers JP, Slotman BJ, Lagerwaard FJ, Palacios MA Tags: Radiother Oncol Source Type: research

Overall survival after stereotactic radiotherapy or surgical metastasectomy in oligometastatic renal cell carcinoma patients treated at two Swedish centres 2005-2014.
CONCLUSIONS: OS after SRT was comparable to SM and longer than expected considering patients with adverse risk profiles were common. Fit patients with non-brain metastases treated after an initial period of watchful waiting had the best prognosis. PMID: 29754859 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 10, 2018 Category: Radiology Authors: Stenman M, Sinclair G, Paavola P, Wersäll P, Harmenberg U, Lindskog M Tags: Radiother Oncol Source Type: research

Respiratory motion-resolved, self-gated 4D-MRI using Rotating Cartesian K-space (ROCK): Initial clinical experience on an MRI-guided radiotherapy system.
CONCLUSION: Our study demonstrated the clinical feasibility of using the ROCK-4D-MRI to acquire high quality, respiratory motion-resolved 4D-MRI in a low-field MRgRT system. The 4D-MRI image could provide accurate dynamic information for radiotherapy treatment planning. PMID: 29753549 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 9, 2018 Category: Radiology Authors: Han F, Zhou Z, Du D, Gao Y, Rashid S, Cao M, Shaverdian N, Hegde JV, Steinberg M, Lee P, Raldow A, Low DA, Sheng K, Yang Y, Hu P Tags: Radiother Oncol Source Type: research

Rescue procedure for an electrical storm using robotic non-invasive cardiac radio-ablation.
We report here an intensive care patient suffering from an electrical storm due to incessant VT, unresponsive to catheter ablation and anti-arrhythmic drugs, showing an immediate and durable response to electrophysiology-guided cardiac SBRT. PMID: 29753550 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 9, 2018 Category: Radiology Authors: Jumeau R, Ozsahin M, Schwitter J, Vallet V, Duclos F, Zeverino M, Moeckli R, Pruvot E, Bourhis J Tags: Radiother Oncol Source Type: research

Development of quality indicators to monitor radiotherapy care for men with prostate cancer: A modified Delphi method.
CONCLUSION: This study developed a core set of 17 QIs which will be used to report from the Prostate Cancer Outcomes Registry-Australia & New Zealand, to monitor the quality of radiotherapy care prostate cancer patients receive. PMID: 29753551 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 9, 2018 Category: Radiology Authors: Tsiamis E, Millar J, Baxi S, Borg M, De Ieso P, Elsaleh H, Foroudi F, Higgs B, Holt T, Martin J, Moretti K, Pryor D, Skala M, Evans S Tags: Radiother Oncol Source Type: research

Early ultrasonographic tumor regression after linear accelerator stereotactic fractionated photon radiotherapy of choroidal melanoma as a predictor for metastatic spread.
i R Abstract BACKGROUND AND PURPOSE: During extended follow-up (of up to 15 years), approximately fifty percent of patients with choroidal melanoma will develop metastatic disease and eventually die. Thus, continuing research on prognostic factors, early detection and treatment is necessary. Height regression rates both after plaque brachytherapy and proton beam irradiation have been shown to have prognostic value. The purpose of this study was to analyze the influence of early tumor regression rate after treatment of choroidal melanoma with LINAC stereotactic fractionated radiotherapy (SFRT) as an independent r...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 8, 2018 Category: Radiology Authors: Mitsch C, Zehetmayer M, Gleiss A, Georg D, Dieckmann K, Pötter R, Sayegh R, Schmidt-Erfurth U, Dunavoelgyi R Tags: Radiother Oncol Source Type: research

Is prophylactic cranial irradiation (PCI) needed in patients with extensive-stage small cell lung cancer showing complete response to first-line chemotherapy?
Abstract Throughout the entire world, prophylactic cranial irradiation (PCI) is the standard care for patients with small cell lung cancer (SCLC) in whom a favorable therapeutic effect is achieved after front-line treatment, regardless of whether the disease is in the limited stage or extensive stage. In the EORTC study, PCI was shown to confer a survival benefit for patients with extensive-stage small cell lung cancer (ES-SCLC) who experienced any positive response after initial chemotherapy. However, the Japan study failed to confirm a survival benefit. As a result, the guidelines in Japan recommend that PCI sho...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 7, 2018 Category: Radiology Authors: Nosaki K, Seto T, Shimokawa M, Takahashi T, Yamamoto N Tags: Radiother Oncol Source Type: research

Assessment of image quality of a radiotherapy-specific hardware solution for PET/MRI in head and neck cancer patients.
CONCLUSIONS: Simultaneous PET/MRI in HNC patients using radiotherapy positioning aids is clinically feasible. Though SNR was reduced, the image quality obtained with a radiotherapy setup meets RTP requirements and the data can thus be used for personalized RTP. PMID: 29747873 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 7, 2018 Category: Radiology Authors: Winter RM, Leibfarth S, Schmidt H, Zwirner K, Mönnich D, Welz S, Schwenzer NF, la Fougère C, Nikolaou K, Gatidis S, Zips D, Thorwarth D Tags: Radiother Oncol Source Type: research

Is prophylactic cranial irradiation indicated for patients with extensive-stage small cell lung cancer with a complete response to first-line treatment?
Abstract Prophylactic cranial irradiation (PCI) has been considered standard of care for patients with limited-stage small-cell lung cancer who achieve complete response to definitive treatment after a meta-analysis revealed its favorable effects on survival. In a European trial, PCI was also shown to confer a survival advantage for patients with extensive-stage (ES) SCLC who experienced any positive response after initial chemotherapy, leading to PCI also being considered a standard treatment for these patients as well. However, a recent Japanese trial investigating PCI for patients with ES-SCLC was stopped early...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 7, 2018 Category: Radiology Authors: Suzuki R, Komaki R Tags: Radiother Oncol Source Type: research

Radiotherapy is essential after complete response to asparaginase-containing chemotherapy in early-stage extranodal nasal-type NK/T-cell lymphoma: A multicenter study from the China Lymphoma Collaborative Group (CLCG).
This study aimed to clarify the benefit of radiotherapy (RT) in patients with early-stage extranodal NK/T-cell lymphoma (NKTCL) who achieve a complete response (CR) after asparaginase-containing chemotherapy (CT). PATIENTS AND METHODS: Of 240 patients achieved a CR after asparaginase-containing CT, 202 patients received additional RT (CT + RT), and 38 patients did not (CT alone). RESULTS: Compared to CT alone, CT + RT significantly improved overall survival (OS), disease-free survival (DFS) and locoregional control (LRC). The 5-year OS, DFS and LRC rates were 84.9%, 76.2% and 84.9% for CT + RT, compar...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 5, 2018 Category: Radiology Authors: Deng XW, Wu JX, Wu T, Zhu SY, Shi M, Su H, Wang Y, He X, Xu LM, Yuan ZY, Zhang LL, Wu G, Qu BL, Qian LT, Hou XR, Zhang FQ, Zhang YJ, Zhu Y, Cao JZ, Lan SM, Dong M, Qi SN, Yang Y, Li YX Tags: Radiother Oncol Source Type: research

Volumetric modulated arc therapy of head-and-neck cancer on a fast-rotating O-ring linac: Plan quality and delivery time comparison with a C-arm linac.
CONCLUSION: For VMAT of HNC, the fast-rotating O-ring linac at least maintains the plan quality of two arcs on a C-arm linac while reducing the image acquisition and plan delivery time. PMID: 29739713 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 5, 2018 Category: Radiology Authors: Michiels S, Poels K, Crijns W, Delombaerde L, De Roover R, Vanstraelen B, Haustermans K, Nuyts S, Depuydt T Tags: Radiother Oncol Source Type: research

Comparison of survival and prognostic factors in patients treated with stereotactic body radiotherapy for oligometastases or oligoprogression.
CONCLUSION: Survival and distant relapse following SBRT to OM/OP is determined by the extent of metastatic disease and performance status. Future research should address the benefit of integrating SBRT with systemic therapies to allow deferral or continuation of therapeutic agents. PMID: 29735409 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 4, 2018 Category: Radiology Authors: Pembroke CA, Fortin B, Kopek N Tags: Radiother Oncol Source Type: research

Distinct shifts in the oral microbiota are associated with the progression and aggravation of mucositis during radiotherapy.
CONCLUSION: Our results suggest that dysbiosis of oral mucosal microbiota may contribute to exacerbating the severity of mucositis in patients undergoing radiotherapy for nasopharyngeal carcinoma. PMID: 29735410 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 4, 2018 Category: Radiology Authors: Hou J, Zheng H, Li P, Liu H, Zhou H, Yang X Tags: Radiother Oncol Source Type: research