Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

A potential biomarker of radiosensitivity in metastatic hormone sensitive prostate cancer patients treated with combination external beam radiotherapy and radium-223
CONCLUSIONS: While some patients responded to this combination treatment, others relapsed within one year of treatment initiation. This study identifies a biomarker based approach that may be useful in predicting which patients will respond to treatment, by monitoring both increases in DNA damage above baseline levels in circulating lymphocytes and decreases in red blood cell and hemoglobin counts during treatment. All data generated and analyzed during this study are included in this published article.PMID:38135185 | DOI:10.1016/j.radonc.2023.110063 (Source: Radiotherapy and Oncology : journal of the European Society for ...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 22, 2023 Category: Radiology Authors: K M Redmond P G Turner A Cole S Jain K M Prise J M O'Sullivan Source Type: research

Identification of the unfolded protein response pathway as target for radiosensitization in pancreatic cancer
CONCLUSION: So, our data show evidence that the UPR is involved in radioresistance of PDAC. Increased apoptosis and a G1 cell cycle arrest seem to be responsible for the radiosensitizing effect of UPR inhibition. These findings are supportive for developing novel combination treatment concepts in PDAC to overcome radioresistance.PMID:38135186 | DOI:10.1016/j.radonc.2023.110059 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 22, 2023 Category: Radiology Authors: Jana Kern Daniela Schilling Christian Schneeweis Roland M Schmid G ünter Schneider Stephanie E Combs Sophie Dobiasch Source Type: research

Stereotactic MR-guided on-table adaptive radiation therapy (SMART) for borderline resectable and locally advanced pancreatic cancer: a multi-center, open-label phase 2 study
CONCLUSIONS: Long-term outcomes from the phase 2 SMART trial demonstrate encouraging OS and limited severe toxicity. Additional prospective evaluation of this novel strategy is warranted.PMID:38135187 | DOI:10.1016/j.radonc.2023.110064 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 22, 2023 Category: Radiology Authors: Michael D Chuong Percy Lee Daniel A Low Joshua Kim Kathryn E Mittauer Michael F Bassetti Carri K Glide-Hurst Ann C Raldow Yingli Yang Lorraine Portelance Kyle R Padgett Bassem Zaki Rongxiao Zhang Hyun Kim Lauren E Henke Alex T Price Joseph D Mancias Chris Source Type: research

Phase I dose-escalation study of nab-paclitaxel combined with cisplatin and capecitabin as induction chemotherapy followed by concurrent chemoradiotherapy in patients with nasopharyngeal carcinoma
CONCLUSION: The RP2D is nab-paclitaxel 200 mg/m2 on day 1, combined with cisplatin 75 mg/mg2 on day 1 and capecitabin1000 mg/m2 on days 1-14, twice a day, every 3 weeks, for three cycles as an IC regimen prior to CCRT.TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT04850235.PMID:38135184 | DOI:10.1016/j.radonc.2023.110051 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 22, 2023 Category: Radiology Authors: None Yu-Chen Mei-Juan Luo Rong-Ping Liu Jing Jin Sheng-Wen Deng Lin-Quan Tang Xiao-Yun Li Li-Ting Liu Dong-Hua Luo Rui Sun Sai-Lan Liu Ji-Bin Li Qing Liu Pan Wang Qiu-Yan Chen Hai-Qiang Mai Shan-Shan Guo Source Type: research

Comment on: Improved Local Control following Dose-Escalated Stereotactic Ablative Radiation Therapy (SABR) for Metastatic Sarcomas: An International Multi-Institutional Experience
Radiother Oncol. 2023 Dec 18:110062. doi: 10.1016/j.radonc.2023.110062. Online ahead of print.NO ABSTRACTPMID:38122849 | DOI:10.1016/j.radonc.2023.110062 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 20, 2023 Category: Radiology Authors: Yupeng Di Jiazhao Song Lingling Meng Source Type: research

Deep learning-based automatic segmentation of cardiac substructures for lung cancers
CONCLUSION: We demonstrated the effectiveness of our nnU-Net model for delineating cardiac substructures, including coronary arteries. Our results indicate that this model has promise for studies regarding radiation dose to cardiac substructures.PMID:38122850 | DOI:10.1016/j.radonc.2023.110061 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 20, 2023 Category: Radiology Authors: Xinru Chen Raymond P Mumme Kelsey L Corrigan Yuki Mukai-Sasaki Efstratios Koutroumpakis Nicolas L Palaskas Callistus M Nguyen Yao Zhao Kai Huang Cenji Yu Ting Xu Aji Daniel Peter A Balter Xiaodong Zhang Joshua S Niedzielski Sanjay S Shete Anita Deswal Lau Source Type: research

An open source auto-segmentation algorithm for delineating heart and substructures - Development and validation within a multicenter lung cancer cohort
Radiother Oncol. 2023 Dec 18:110065. doi: 10.1016/j.radonc.2023.110065. Online ahead of print.NO ABSTRACTPMID:38122851 | DOI:10.1016/j.radonc.2023.110065 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 20, 2023 Category: Radiology Authors: Agon Olloni Ebbe Laugaard Lorenzen Stefan Starup Jeppesen Axel Diederichsen Robert Finnegan Lone Hoffmann Charlotte Kristiansen Marianne Knap Marie Louise Holm Milo Ditte Sloth M øller Mette P øhl Gitte Persson Hella Mb Sand Nis Sarup Rune Thing Carsten Source Type: research

Essential requirements for reporting radiation therapy in breast cancer clinical trials: an international multi-disciplinary consensus endorsed by the European SocieTy for Radiotherapy and Oncology (ESTRO)
This article is grounded in a consensus recommendation endorsed by ESTRO, formulated by international breast cancer experts. The consensus was reached through a modified Delphi process and was presented at an international meeting convened in Florence, Italy, in June 2023. These recommendations are regarded as both optimal and essential standards, with the latter aiming to define the minimum requirements. A template for a case report form (CRF) has been devised, which can be utilised by all clinical breast cancer trials involving RT. Optimal requirements include adherence to predefined RT planning protocols and centralised...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 20, 2023 Category: Radiology Authors: Orit Kaidar-Person Icro Meattini Liesbeth J Boersma Carlotta Becherini Javier Cortes Giuseppe Curigliano Evandro de Azambuja Nadia Harbeck Hope S Rugo Lucia Del Mastro Alessandra Gennari Clare M Isacke Maja Vestm ø Maraldo Elisabetta Marangoni Gustavo Na Source Type: research

In Reply To: Comment on: Improved Local Control following Dose-Escalated Stereotactic Ablative Radiation Therapy (SABR) for Metastatic Sarcomas: An International Multi-Institutional Experience
Radiother Oncol. 2023 Dec 18:110058. doi: 10.1016/j.radonc.2023.110058. Online ahead of print.NO ABSTRACTPMID:38122853 | DOI:10.1016/j.radonc.2023.110058 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 20, 2023 Category: Radiology Authors: Raj Singh Source Type: research