Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology RSS feedThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Late normal tissue effects in the arm and shoulder following lymphatic radiotherapy: Results from the UK START (Standardisation of Breast Radiotherapy) trials.
CONCLUSIONS: The START trial results suggest that appropriately-dosed hypofractionated LNRT is safe in the long-term, according to patient and physician-assessed arm and shoulder symptoms. These findings are consistent with those reported after the same schedules delivered to the breast/chest wall. PMID: 29153463 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 15, 2017 Category: Radiology Authors: Haviland JS, Mannino M, Griffin C, Porta N, Sydenham M, Bliss JM, Yarnold JR, START Trialists' Group Tags: Radiother Oncol Source Type: research

International guideline for the delineation of the clinical target volumes (CTV) for nasopharyngeal carcinoma.
CONCLUSION: Through this comprehensive review of available evidence and best practices at major institutions, as well as interactive exchange of vast experience by international experts, this set of consensus guidelines has been developed to provide a practical reference for appropriate contouring to ensure optimal target coverage. However, the final decision on the treatment volumes should be based on full consideration of individual patients' factors and facilities of an individual centre (including the quality of imaging methods and the precision of treatment delivery). PMID: 29153464 [PubMed - as supplied by publi...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 15, 2017 Category: Radiology Authors: Lee AW, Ng WT, Pan JJ, Poh SS, Ahn YC, AlHussain H, Corry J, Grau C, Grégoire V, Harrington KJ, Hu CS, Kwong DL, Langendijk JA, Le QT, Lee NY, Lin JC, Lu TX, Mendenhall WM, O'Sullivan B, Ozyar E, Peters LJ, Rosenthal DI, Soong YL, Tao Y, Yom SS, Wee JT Tags: Radiother Oncol Source Type: research

Impact of hybrid PET/MR technology on multiparametric imaging and treatment response assessment of cervix cancer.
g D Abstract BACKGROUND AND PURPOSE: Multimodal tissue characterization by combined MRI and PET has high clinical potential in the context of sub-target definition for dose painting and response assessment but its clinical exploration is yet limited. The aim of this study was to prove the potential and feasibility of hybrid PET/MRI to non-invasively measure tumor hypoxia, perfusion and microstructure at one stop in tumors of the uterine cervix during chemoradiotherapy. MATERIAL AND METHODS: Ten cervix cancer patients were subjected to simultaneous multiparametric PET/MRI with [(18)F]fluoromisonidazole ([(18)F...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 15, 2017 Category: Radiology Authors: Daniel M, Andrzejewski P, Sturdza A, Majercakova K, Baltzer P, Pinker K, Wadsak W, Mitterhauser M, Pötter R, Georg P, Helbich T, Georg D Tags: Radiother Oncol Source Type: research

Medical physics in radiation Oncology: New challenges, needs and roles.
PMID: 29150160 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 14, 2017 Category: Radiology Authors: Georg D, Thwaites D Tags: Radiother Oncol Source Type: research

Improved pharmacodynamic (PD) assessment of low dose PARP inhibitor PD activity for radiotherapy and chemotherapy combination trials.
CONCLUSIONS: Combination trials of radiotherapy and novel targeted agent(s) often require different and more sensitive PD assessments than in the monotherapy setting. This study shows the benefit and relevance of sensitive and adapted PD-assays for such combination purposes and provides proof of clinically relevant cellular PARP inhibitory activities at low daily olaparib doses. PMID: 29150161 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 14, 2017 Category: Radiology Authors: de Haan R, Pluim D, van Triest B, van den Heuvel M, Peulen H, van Berlo D, George J, Verheij M, Schellens JHM, Vens C Tags: Radiother Oncol Source Type: research

Geometric and dosimetric accuracy of dynamic tumor tracking during volumetric-modulated arc therapy using a gimbal mounted linac.
CONCLUSIONS: The positional, mechanical and dosimetric accuracy of DTT-VMAT were evaluated. DTT-VMAT with a gimbal-mounted linac had sufficient accuracy and presents a new strategy for treatment of several tumors with respiratory motion. PMID: 29137808 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 11, 2017 Category: Radiology Authors: Ono T, Miyabe Y, Takahashi K, Akimoto M, Mukumoto N, Ishihara Y, Nakamura M, Mizowaki T, Hiraoka M Tags: Radiother Oncol Source Type: research

Delineating sites of failure following post-prostatectomy radiation treatment using (68)Ga-PSMA-PET.
CONCLUSION: Post-prostatectomy radiation treatment resulted in excellent in-field control rates. Isolated pelvic nodal failure was rare in those receiving radiotherapy to the prostatic fossa and pelvic nodes but accounted for one third of failures in those receiving PF alone treatment. PMID: 29132644 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 10, 2017 Category: Radiology Authors: Byrne K, Eade T, Kneebone A, Guo L, Hsiao E, Schembri G, Kwong C, Hunter J, Emmett L, Hruby G Tags: Radiother Oncol Source Type: research

A prospective evaluation of hippocampal radiation dose volume effects and memory deficits following cranial irradiation.
CONCLUSIONS: This prospective study demonstrates an association between hippocampal dose volume effects and memory decline measured by HVLT-R DR over a wide dose range. These data support a potential benefit of hippocampal sparing and encourage continued trial enrollment. PMID: 29128167 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 8, 2017 Category: Radiology Authors: Ma TM, Grimm J, McIntyre R, Anderson-Keightly H, Kleinberg LR, Hales RK, Moore J, Vannorsdall T, Redmond KJ Tags: Radiother Oncol Source Type: research

Is dose de-escalation possible in sarcoma patients treated with enlarged limb sparing resection?
oux C Abstract PURPOSE: To evaluate the impact of dose de-escalation in a large series of resected limbs soft tissue sarcomas (STS). METHODS: Data were retrospectively analysed from 414 consecutive patients treated for limb STS by enlarged surgery and radiotherapy at Gustave Roussy from 05/1993 to 05/2012. Radiotherapy (RT) dose level was decided by the multidisciplinary staff and depended upon the quality of surgery and margins size. RESULTS: RT was delivered prior (13%) or after (87%) surgery. Seven patients (2%) had pre- and a postoperative RT boost. Median delivered RT dose was 50 Gy (36-70 Gy), ...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 7, 2017 Category: Radiology Authors: Levy A, Bonvalot S, Bellefqih S, Terrier P, Le Cesne A, Le Péchoux C Tags: Radiother Oncol Source Type: research

Post-radiochemotherapy PET radiomics in head and neck cancer - The influence of radiomics implementation on the reproducibility of local control tumor models.
CONCLUSION: The two post-RCT PET radiomic models, based on two different software implementations, were prognostic for local tumor control in HNSCC. However, 88% of the features was not reproducible between the implementations. PMID: 29122358 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 6, 2017 Category: Radiology Authors: Bogowicz M, Leijenaar RTH, Tanadini-Lang S, Riesterer O, Pruschy M, Studer G, Unkelbach J, Guckenberger M, Konukoglu E, Lambin P Tags: Radiother Oncol Source Type: research

Prognostic impact of RITA expression in patients with anal squamous cell carcinoma treated with chemoradiotherapy.
l;del C, Yuan J Abstract BACKGROUND: RBP-J interacting and tubulin-associated protein (RITA) has been identified as a negative regulator of the Notch signalling pathway and its deregulation is involved in the pathogenesis of several tumour entities. RITA's impact on the response of anal squamous cell carcinoma (SCC) to anticancer treatment, however, remains elusive. MATERIALS AND METHODS: In our retrospective study immunohistochemical evaluation of RITA was performed on 140 pre-treatment specimens and was correlated with clinical and histopathologic characteristics and clinical endpoints cumulative incidence ...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 6, 2017 Category: Radiology Authors: Rödel F, Steinhäuser K, Kreis NN, Friemel A, Martin D, Wieland U, Rave-Fränk M, Balermpas P, Fokas E, Louwen F, Rödel C, Yuan J Tags: Radiother Oncol Source Type: research

Association between treatment planning and delivery factors and disease progression in prostate cancer radiotherapy: Results from the TROG 03.04 RADAR trial.
Abstract BACKGROUND AND PURPOSE: To evaluate the impact of treatment planning and delivery factors on treatment outcome as measured by post-treatment disease progression. MATERIALS AND METHODS: Accruing 813 external beam radiotherapy participants during 2003-2007, the RADAR trial collected a comprehensive range of clinical treatment factor data for each participant. Both the Fine and Gray competing risks modelling and the Kaplan-Meier (KM) analysis were undertaken to determine the impact of these factors on local-composite progression (LCP), with 709 participants available for analysis. RESULTS: Particip...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 6, 2017 Category: Radiology Authors: Marcello M, Ebert M, Haworth A, Steigler A, Kennedy A, Joseph D, Denham J Tags: Radiother Oncol Source Type: research

Ventilation measured on clinical 4D-CBCT: Increased ventilation accuracy through improved image quality.
CONCLUSION: The study showed that the combination of improved projection correction and the SART reconstruction increased the accuracy of CBCT ventilation and this result can be a stepping stone to extract dynamic changes in respiration pattern of patients during radiotherapy. PMID: 29122361 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 6, 2017 Category: Radiology Authors: Jensen KR, Brink C, Hansen O, Bernchou U Tags: Radiother Oncol Source Type: research

With or without consolidation chemotherapy using cisplatin/5-FU after concurrent chemoradiotherapy in stage II-III squamous cell carcinoma of the esophagus: A propensity score-matched analysis.
CONCLUSIONS: Compared to CCRT alone, consolidation chemotherapy did not further prolong progression-free survival and overall survival for patients with stage II-III squamous cell carcinoma of the esophagus. The role of consolidation therapy needs to be studied further. PMID: 29122362 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 6, 2017 Category: Radiology Authors: Chen Y, Guo L, Cheng X, Wang J, Zhang Y, Wang Y, Ke S, Shi W Tags: Radiother Oncol Source Type: research

Clustering of multi-parametric functional imaging to identify high-risk subvolumes in non-small cell lung cancer.
CONCLUSIONS: We designed a subregional analysis for multi-parametric imaging in NSCLC, and showed the potential of subregion classification as a biomarker for prognosis. This methodology allows for a comprehensive data-driven analysis of multi-parametric functional images. PMID: 29122363 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 6, 2017 Category: Radiology Authors: Even AJG, Reymen B, La Fontaine MD, Das M, Mottaghy FM, Belderbos JSA, De Ruysscher D, Lambin P, van Elmpt W Tags: Radiother Oncol Source Type: research

Sensitivity of a prompt-gamma slit-camera to detect range shifts for proton treatment verification.
CONCLUSIONS: Detection of global and local range shifts under close-to-clinical conditions is possible with the PGI slit-camera. Especially for PBS, high sensitivity and high accuracy in shift detection were found. PMID: 29113697 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 4, 2017 Category: Radiology Authors: Nenoff L, Priegnitz M, Janssens G, Petzoldt J, Wohlfahrt P, Trezza A, Smeets J, Pausch G, Richter C Tags: Radiother Oncol Source Type: research

Impact of dose intensified salvage radiation therapy on urinary continence recovery after radical prostatectomy: Results of the randomized trial SAKK 09/10.
CONCLUSIONS: Dose intensification of sRT had no impact on early urinary continence recovery or prevalence of de novo incontinence. PMID: 29103826 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 3, 2017 Category: Radiology Authors: Ghadjar P, Hayoz S, Bernhard J, Zwahlen DR, Stein J, Hölscher T, Gut P, Polat B, Hildebrandt G, Müller AC, Putora PM, Papachristofilou A, Schär C, Dal Pra A, Biaggi Rudolf C, Wust P, Aebersold DM, Thalmann GN, Swiss Group for Clinical Cancer Research ( Tags: Radiother Oncol Source Type: research

Whole-body total lesion glycolysis is an independent predictor in patients with esophageal cancer treated with definitive chemoradiotherapy.
CONCLUSION: TLGWB and MTVWB are independent predictors in patients with esophageal cancer. PMID: 29108779 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 3, 2017 Category: Radiology Authors: Takahashi N, Umezawa R, Takanami K, Yamamoto T, Ishikawa Y, Kozumi M, Takeda K, Kadoya N, Jingu K Tags: Radiother Oncol Source Type: research

Automated, reference-free local error assessment of multimodal deformable image registration for radiotherapy in the head and neck.
CONCLUSIONS: b-MI and b-pmMI algorithms have been validated as providing accurate reference-free quantitative assessment of DIR accuracy on a per-patient basis. b-pmMI is faster and more robust in the presence of modality-specific information. PMID: 29100697 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 31, 2017 Category: Radiology Authors: Nix MG, Prestwich RJD, Speight R Tags: Radiother Oncol Source Type: research

A virtual dosimetry audit - Towards transferability of gamma index analysis between clinical trial QA groups.
Abstract PURPOSE: Quality assurance (QA) for clinical trials is important. Lack of compliance can affect trial outcome. Clinical trial QA groups have different methods of dose distribution verification and analysis, all with the ultimate aim of ensuring trial compliance. The aim of this study was to gain a better understanding of different processes to inform future dosimetry audit reciprocity. MATERIALS: Six clinical trial QA groups participated. Intensity modulated treatment plans were generated for three different cases. A range of 17 virtual 'measurements' were generated by introducing a variety of simula...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 31, 2017 Category: Radiology Authors: Hussein M, Clementel E, Eaton DJ, Greer PB, Haworth A, Ishikura S, Kry SF, Lehmann J, Lye J, Monti AF, Nakamura M, Hurkmans C, Clark CH, Global Quality Assurance of Radiation Therapy Clinical Trial Harmonisation Group Tags: Radiother Oncol Source Type: research

Glucose starvation impairs DNA repair in tumour cells selectively by blocking histone acetylation.
CONCLUSIONS: In resting tumour cells, glucose starvation combined with irradiation resulted in the impairment of late DSB repair and the reduction of clonogenic survival, which was associated with disrupted radiation-induced histone acetylation. However, in normal cells, DNA repair and radiosensitivity were not affected by glucose depletion. PMID: 29100699 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 31, 2017 Category: Radiology Authors: Ampferl R, Rodemann HP, Mayer C, Höfling TTA, Dittmann K Tags: Radiother Oncol Source Type: research

Prognostic impact of HPV-associated p16-expression and smoking status on outcomes following radiotherapy for oropharyngeal cancer: The MARCH-HPV project.
CONCLUSIONS: No predictive impact of p16-status on response to AFRT could be detected but the strong prognostic impact of p16-status was confirmed and especially p16-positive never smoking patients have superior outcome after RT. PMID: 29100700 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 31, 2017 Category: Radiology Authors: Lassen P, Lacas B, Pignon JP, Trotti A, Zackrisson B, Zhang Q, Overgaard J, Blanchard P, MARCH Collaborative Group Tags: Radiother Oncol Source Type: research

Robustness of patient positioning for interfractional error in carbon ion radiotherapy for stage I lung cancer: Bone matching versus tumor matching.
Abstract BACKGROUND AND PURPOSE: Patient positioning was compared by tumor matching (TM) and conventional bony structure matching (BM) in carbon ion radiotherapy for stage I non-small cell lung cancer to evaluate the robustness of TM and BM in determining interfractional error. MATERIAL AND METHODS: Sixty irradiation fields were analyzed. Computed tomography (CT) images acquired before treatment initiation for confirmation (Conf-CT) were obtained under the same settings as the treatment planning CT images and used to evaluate both positioning methods. The dose distributions were recalculated for Conf-CT using...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 31, 2017 Category: Radiology Authors: Sakai M, Kubota Y, Saitoh JI, Irie D, Shirai K, Okada R, Torikoshi M, Ohno T, Nakano T Tags: Radiother Oncol Source Type: research

Intensity-based dual model method for generation of synthetic CT images from standard T2-weighted MR images - Generalized technique for four different MR scanners.
CONCLUSIONS: The study provides a generalized method for sCT creation from standard T2w images of the pelvis. The method produced clinically acceptable dose calculation results for all the included scanners and MR sequences. PMID: 29097012 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 30, 2017 Category: Radiology Authors: Koivula L, Kapanen M, Seppälä T, Collan J, Dowling JA, Greer PB, Gustafsson C, Gunnlaugsson A, Olsson LE, Wee L, Korhonen J Tags: Radiother Oncol Source Type: research

Is the coronary artery calcium score associated with acute coronary events in breast cancer patients treated with radiotherapy?
CONCLUSIONS: High pre-treatment CAC is associated with ACE in BC patients treated with postoperative RT, even after correction for confounding factors such as MHD. PMID: 29089148 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 28, 2017 Category: Radiology Authors: Roos CTG, van den Bogaard VAB, Greuter MJW, Vliegenthart R, Schuit E, Langendijk JA, van der Schaaf A, Crijns APG, Maduro JH Tags: Radiother Oncol Source Type: research

Prognostic value of tissue necrosis, hypoxia-related markers and correlation with HPV status in head and neck cancer patients treated with bio- or chemo-radiotherapy.
CONCLUSIONS: The combination of MVD and CA-IX expression might give additional prognostic information in HNSCC patients with known HPV status. PMID: 29079308 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 24, 2017 Category: Radiology Authors: Ou D, Garberis I, Adam J, Blanchard P, Nguyen F, Levy A, Casiraghi O, Gorphe P, Breuskin I, Janot F, Temam S, Scoazec JY, Deutsch E, Tao Y Tags: Radiother Oncol Source Type: research

Receipt of thoracic radiation therapy and radiotherapy dose are correlated with outcomes in a retrospective study of three hundred and six patients with extensive stage small-cell lung cancer.
Abstract BACKGROUND: The importance of the thoracic radiation therapy (TRT) dose has not been clearly defined in extensive stage small-cell lung cancer (ES-SCLC) and it is unclear whether improved TRT dose translates into a survival benefit. METHODS: 306 patients with ES-SCLC were retrospectively reviewed, of which 170 received IMRT/CRT fractionation RT after ChT, and 136 received chemotherapy (ChT) alone. We adopted the time-adjusted BED (tBED) for effective dose fractionation calculation. Due to the nonrandomized nature of this study, we compared the ChT+RT with ChT groups that matched on possible confoundi...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 24, 2017 Category: Radiology Authors: Li-Ming X, Zhao LJ, Simone CB, Cheng C, Kang M, Wang X, Gong LL, Pang QS, Wang J, Yuan ZY, Wang P Tags: Radiother Oncol Source Type: research

Dosimetric feasibility of the hybrid Magnetic Resonance Imaging (MRI)-linac System (MRL) for brain metastases: The impact of the magnetic field.
Abstract BACKGROUND AND PURPOSE: We aimed to investigate the suitability of treating patients with single brain metastases using stereotactic radiosurgery (SRS) with the MRL and to characterize the dosimetric impact at tissue-air interfaces resulting primarily from the electron return effect (ERE). MATERIAL AND METHODS: 24 patients treated for intact single brain metastases were analyzed. Three radiotherapy plans with the same prescribed dose were generated for each case: (1) noncoplanar volumetric modulated arc therapy (VMAT), (2) coplanar step-and-shoot intensity modulated radiotherapy (IMRT) on the MRL in ...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 24, 2017 Category: Radiology Authors: Tseng CL, Eppinga W, Seravalli E, Hackett S, Brand E, Ruschin M, Lee YK, Atenafu EG, Sahgal A Tags: Radiother Oncol Source Type: research

The impact of treatment accuracy on proton therapy patient selection for oropharyngeal cancer patients.
CONCLUSIONS: Treatment accuracy has a significant impact on the number of patients selected for proton therapy. Therefore, it cannot be ignored in estimating the number of patients for proton therapy. PMID: 29074078 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 23, 2017 Category: Radiology Authors: Arts T, Breedveld S, de Jong MA, Astreinidou E, Tans L, Keskin-Cambay F, Krol ADG, van de Water S, Bijman RG, Hoogeman MS Tags: Radiother Oncol Source Type: research

High dose rate brachytherapy as monotherapy for localised prostate cancer.
CONCLUSIONS: Our results confirm HDR BRT to be a safe and effective monotherapeutic treatment modality for clinically localised prostate cancer. PMID: 29074079 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 23, 2017 Category: Radiology Authors: Strouthos I, Tselis N, Chatzikonstantinou G, Butt S, Baltas D, Bon D, Milickovic N, Zamboglou N Tags: Radiother Oncol Source Type: research

Pelvic re-irradiation using stereotactic ablative radiotherapy (SABR): A systematic review.
CONCLUSIONS: For previously irradiated patients with recurrent pelvic disease, SABR re-irradiation could be a feasible intervention for those who otherwise have limited options. Evidence to support this technique is limited but shows initial promise. Based on the available literature, suggestions for a more formal SABR re-irradiation pathway are proposed. Prospective studies and a multidisciplinary approach are required to optimise future treatment. PMID: 29066125 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 21, 2017 Category: Radiology Authors: Murray LJ, Lilley J, Hawkins MA, Henry AM, Dickinson P, Sebag-Montefiore D Tags: Radiother Oncol Source Type: research

SDF-1/CXCR4 expression is an independent negative prognostic biomarker in patients with head and neck cancer after primary radiochemotherapy.
CONCLUSIONS: Our data support the importance of SDF-1 and CXCR4 expression for loco-regional control and overall survival in HNSCC after primary radiochemotherapy. Prospective multivariate validation and further studies into CXCR4 inhibition to overcome radiation resistance are warranted. PMID: 29061496 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 20, 2017 Category: Radiology Authors: De-Colle C, Menegakis A, Mönnich D, Welz S, Boeke S, Sipos B, Fend F, Mauz PS, Tinhofer I, Budach V, Abu Jawad J, Stuschke M, Balermpas P, Rödel C, Grosu AL, Abdollahi A, Debus J, Belka C, Ganswindt U, Pigorsch S, Combs SE, Lohaus F, Linge A, Krause M, Tags: Radiother Oncol Source Type: research

Prospective clinical validation of independent DVH prediction for plan QA in automatic treatment planning for prostate cancer patients.
CONCLUSION: A high accuracy DVH prediction tool was developed and used for independent QA of automatically generated plans. In 28% of plans, minor dosimetric deviations were observed that could be improved by plan adjustments. Larger gains are expected for manually generated plans. PMID: 29061497 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 20, 2017 Category: Radiology Authors: Wang Y, Heijmen BJM, Petit SF Tags: Radiother Oncol Source Type: research

The extent of edema and tumor synchronous invasion into the subventricular zone and corpus callosum classify outcomes and radiotherapy strategies of glioblastomas.
CONCLUSIONS: Our results support the need for developing individualized irradiation strategies for glioblastomas according to EPE and sSVZCC. PMID: 29056290 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 19, 2017 Category: Radiology Authors: Liang HT, Chen WY, Lai SF, Su MY, You SL, Chen LH, Tseng HM, Chen CM, Kuo SH, Tseng WI Tags: Radiother Oncol Source Type: research

ATR/CHK1 inhibitors and cancer therapy.
Abstract The cell cycle checkpoint proteins ataxia-telangiectasia-mutated-and-Rad3-related kinase (ATR) and its major downstream effector checkpoint kinase 1 (CHK1) prevent the entry of cells with damaged or incompletely replicated DNA into mitosis when the cells are challenged by DNA damaging agents, such as radiation therapy (RT) or chemotherapeutic drugs, that are the major modalities to treat cancer. This regulation is particularly evident in cells with a defective G1 checkpoint, a common feature of cancer cells, due to p53 mutations. In addition, ATR and/or CHK1 suppress replication stress (RS) by inhibiting ...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 17, 2017 Category: Radiology Authors: Qiu Z, Oleinick NL, Zhang J Tags: Radiother Oncol Source Type: research

Patterns and correlates of treatment failure in relation to isodose distribution in non-small cell lung cancer: An analysis of 1522 patients in the modern era.
CONCLUSION: In this large study of patients treated in the modern era with varying dose fractionation regimens, higher BED was associated with improved freedom from in-field failure, and that this relationship appeared to be consistent with the classically described sigmoid shape. We also found that increased BED was associated with higher field-edge failures, implying that margin size may need to be further studied in patients receiving ablative regimens of radiation. PMID: 29054376 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 17, 2017 Category: Radiology Authors: Pezzi TA, Tang C, Swanick CW, Fang P, Hess K, Xu T, Hahn SM, Chang JY, Liao Z, Gomez D Tags: Radiother Oncol Source Type: research

Patterns of care and outcomes for use of concurrent chemoradiotherapy over radiotherapy alone for anaplastic gliomas.
CONCLUSION: Use of concurrent CRT is associated with more recent year of diagnosis and improved survival relative to RT alone. PMID: 29054377 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 17, 2017 Category: Radiology Authors: Yeboa DN, Rutter CE, Park HS, Lester-Coll NH, Corso CD, Mancini BR, Bindra RS, Contessa J, Yu JB Tags: Radiother Oncol Source Type: research

Multiple-CT optimization of intensity-modulated proton therapy - Is it possible to eliminate adaptive planning?
CONCLUSIONS: The results of this study indicate that an IMPT plan can meet the dose criteria on both PCT and ACT, and that MCT optimization can improve the plan's robustness to anatomical change. PMID: 29054378 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 17, 2017 Category: Radiology Authors: Wang X, Li H, Zhu XR, Hou Q, Liao L, Jiang B, Li Y, Wang P, Lang J, Zhang X Tags: Radiother Oncol Source Type: research

Treatment log files as a tool to identify treatment plan sensitivity to inaccuracies in scanned proton beam delivery.
Abstract Dose distributions delivered at Gantry 2 at the Paul Scherrer Institut (PSI) can be reconstructed on the patient anatomy based on machine log files. With the present work, the dependency of the log file calculation on the planning optimization technique and on other planning parameters, such as field direction and tumour size, has been investigated. Interestingly, and despite the typically higher modulation of Intensity Modulated Proton Therapy (IMPT) plans, the results for both Single Field Uniform Distribution and IMPT approaches have been found to be similar. In addition, complex fields with steep in-f...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 17, 2017 Category: Radiology Authors: Belosi MF, van der Meer R, Garcia de Acilu Laa P, Bolsi A, Weber DC, Lomax AJ Tags: Radiother Oncol Source Type: research

Toxicity and efficacy of re-irradiation of high-grade glioma in a phase I dose- and volume escalation trial.
CONCLUSION: Re-irradiation showed limited efficacy and 43% of patients achieving disease control suffered late toxicity that was manageable but not negligible. PMID: 29054380 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 17, 2017 Category: Radiology Authors: Møller S, Munck Af Rosenschöld P, Costa J, Law I, Poulsen HS, Engelholm SA, Engelholm S Tags: Radiother Oncol Source Type: research

Dual-energy CT based proton range prediction in head and pelvic tumor patients.
CONCLUSIONS: The magnitude of patient-specific range deviations between HLUT and the more accurate DECT-based SPR prediction is clinically relevant. A clinical application of the latter seems feasible as demonstrated in this study using medically approved systems from CT acquisition to treatment planning. PMID: 29050953 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 16, 2017 Category: Radiology Authors: Wohlfahrt P, Möhler C, Stützer K, Greilich S, Richter C Tags: Radiother Oncol Source Type: research

The TRENDY multi-center randomized trial on hepatocellular carcinoma - Trial QA including automated treatment planning and benchmark-case results.
ydt T, Dwarkasing RS, Willemsen FEJA, Heijmen BJM, Méndez Romero A Abstract BACKGROUND AND PURPOSE: The TRENDY trial is an international multi-center phase-II study, randomizing hepatocellular carcinoma (HCC) patients between transarterial chemoembolization (TACE) and stereotactic body radiation therapy (SBRT) with a target dose of 48-54 Gy in six fractions. The radiotherapy quality assurance (QA) program, including prospective plan feedback based on automated treatment planning, is described and results are reported. MATERIALS AND METHODS: Scans of a single patient were used as a benchmark case. Con...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 16, 2017 Category: Radiology Authors: Habraken SJM, Sharfo AWM, Buijsen J, Verbakel WFAR, Haasbeek CJA, Öllers MC, Westerveld H, van Wieringen N, Reerink O, Seravalli E, Braam PM, Wendling M, Lacornerie T, Mirabel X, Weytjens R, Depuydt L, Tanadini-Lang S, Riesterer O, Haustermans K, Depuydt Tags: Radiother Oncol Source Type: research

Palliative radiation therapy in the last 30 days of life: A systematic review.
CONCLUSION: Palliative RT was performed in approximately 10% of patients who died of cancer near their end of life, with the most commonly used regimen of 30 Gy in 10 fractions. This study suggests that greater use of shorter or single fraction regimens may be beneficial, especially in patients with poor performance status. PMID: 29050955 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 16, 2017 Category: Radiology Authors: Park KR, Lee CG, Tseng YD, Liao JJ, Reddy S, Bruera E, Yennurajalingam S Tags: Radiother Oncol Source Type: research

Lung toxicity after radiation in childhood: Results of the International Project on Prospective Analysis of Radiotoxicity in Childhood and Adolescence.
This study presents the evaluation of acute and late toxicities of the lung in children and adolescents after irradiation in terms of dose-volume effects. MATERIALS AND METHODS: Irradiated children and adolescents in Germany have prospectively been documented since 2001 in the "Registry for the Evaluation of Side-Effects after Radiotherapy in Childhood and Adolescence (RiSK)"; in Sweden since 2008 in the RADTOX registry. RESULTS: Up to April 2012, 1,392 children were recruited from RiSK, and up to June 2013, 485 from the RADTOX-registry. Of these patients, 295 were irradiated to the lung. Information ab...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 16, 2017 Category: Radiology Authors: Stoppel G, Eich HT, Matuschek C, Kortmann RD, Meyer F, Martinsson U, Nilsson K, Kristensen I, Vordermark D, Willich N, Christiansen H, Koch R, Steinmann D Tags: Radiother Oncol Source Type: research

Heart dosimetric analysis of three types of cardiac toxicity in patients treated on dose-escalation trials for Stage III non-small-cell lung cancer.
CONCLUSIONS: Cardiac events were heterogeneous and associated with distinct heart subvolume doses. These data support the hypothesis of distinct etiologies for different types of radiation-associated cardiotoxicity. PMID: 29050957 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 16, 2017 Category: Radiology Authors: Wang K, Pearlstein KA, Patchett ND, Deal AM, Mavroidis P, Jensen BC, Lipner MB, Zagar TM, Wang Y, Lee CB, Eblan MJ, Rosenman JG, Socinski MA, Stinchcombe TE, Marks LB Tags: Radiother Oncol Source Type: research

Metal artefact reduction for accurate tumour delineation in radiotherapy.
Abstract BACKGROUND AND PURPOSE: Two techniques for metal artefact reduction for computed tomography were studied in order to identify their impact on tumour delineation in radiotherapy. MATERIALS AND METHODS: Using specially designed phantoms containing metal implants (dental, spine and hip) as well as patient images, we investigated the impact of two methods for metal artefact reduction on (A) the size and severity of metal artefacts and the accuracy of Hounsfield Unit (HU) representation, (B) the visual impact of metal artefacts on image quality and (C) delineation accuracy. A metal artefact reduction algo...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 16, 2017 Category: Radiology Authors: Kovacs DG, Rechner LA, Appelt AL, Berthelsen AK, Costa JC, Friborg J, Persson GF, Bangsgaard JP, Specht L, Aznar MC Tags: Radiother Oncol Source Type: research

Sequential proton boost after standard chemoradiation for high-grade glioma.
Abstract PURPOSE: To retrospectively assess the feasibility and safety of a sequential proton boost following conventional chemoradiation in high-grade glioma (HGG). METHOD AND MATERIALS: Sixty-six consecutive patients with HGG were treated with 50.0 Gy photons (50.0-50.4 Gy) in 2.0 Gy (1.8-2.0 Gy) fractions, followed by a proton boost with 10 Gy equivalent (Gy(RBE)) in 2.0 Gy(RBE) fractions. Patients were matched one to one with 66 patients with HGG undergoing conventional radiation therapy (RT) with 60.0 Gy photons (59.4-60.0 Gy) in 2.0 Gy fractions (1.8-2.0 Gy). Matching criteria were age...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 16, 2017 Category: Radiology Authors: Adeberg S, Bernhardt D, Harrabi SB, Uhl M, Paul A, Bougatf N, Verma V, Unterberg A, Wick W, Haberer T, Combs SE, Herfarth K, Debus J, Rieken S Tags: Radiother Oncol Source Type: research

Mapping patterns of locoregional recurrence following contemporary treatment with radiation therapy for breast cancer: A multi-institutional validation study of the ESTRO consensus guideline on clinical target volume.
CONCLUSIONS: Our mapping data demonstrated that the ESTRO-CTV, with some considerations, successfully encompassed most LRRs in patients undergoing contemporary management, thus validating ESTRO-CTV to be valuable for highly conformal radiation therapy techniques. PMID: 29050960 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 16, 2017 Category: Radiology Authors: Chang JS, Lee J, Chun M, Shin KH, Park W, Lee JH, Kim JH, Yoon WS, Lee IJ, Kim J, Park HL, Kim YB Tags: Radiother Oncol Source Type: research

Neuroendocrine late effects after tailored photon radiotherapy for children with low grade gliomas: Long term correlation with tumour and treatment parameters.
CONCLUSION: Radiotherapy showed excellent OS and PFS rates and acceptable late neuroendocrine toxicity profile in this population of LGG patients treated over a period of 13years. In our experience, the dose to the HPA was predictive of the risk of late endocrine toxicity. PMID: 29037775 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 13, 2017 Category: Radiology Authors: Aloi D, Belgioia L, Barra S, Giannelli F, Cavagnetto F, Gallo F, Milanaccio C, Garrè M, Di Profio S, Di Iorgi N, Corvò R Tags: Radiother Oncol Source Type: research

A multicentre 'end to end' dosimetry audit of motion management (4DCT-defined motion envelope) in radiotherapy.
CONCLUSIONS: A novel, clinically-relevant, end-to-end dosimetry audit of motion management strategies in radiotherapy is reported. PMID: 29037776 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 13, 2017 Category: Radiology Authors: Palmer AL, Nash D, Kearton JR, Jafari SM, Muscat S Tags: Radiother Oncol Source Type: research