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Tumor volume and cancer stem cell expression as prognostic markers for high-dose loco-regional failure in head and neck squamous cell carcinoma - a DAHANCA 19 study
CONCLUSION: Tumor volume, p16, and CSC markers are potential biomarkers for HDF for patients with HNSCC treated with (C-)RT. Lower expression of CSC in p16+ OPSCC may contribute to better tumor control.PMID:38341096 | DOI:10.1016/j.radonc.2024.110149 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 10, 2024 Category: Radiology Authors: Morten Horsholt Kristensen Mia Kristina S ørensen Trine Tramm Jan Alsner Brita Singers S ørensen Christian Maare J ørgen Johansen Hanne Primdahl Åse Bratland Claus Andrup Kristensen Maria Andersen Jacob Kinggaard Lilja-Fischer Anne Ivalu Sander Holm E Source Type: research

Short course radiotherapy versus radiochemotherapy for locally advanced rectal cancers in the elderly (UNICANCER PRODIGE 42/GERICO 12 study): Quality of life and comprehensive geriatric assessment
CONCLUSION: Short course radiotherapy achieves better results in terms of Quality of Life and preservation of autonomy in patients aged ≥75 treated for locally advanced rectal cancer.PMID:38341097 | DOI:10.1016/j.radonc.2024.110144 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 10, 2024 Category: Radiology Authors: Eric Fran çois Nicolas Magn é Rabia Boulahssass Philippe Ronchin Virginie Huguenet Blandine De Lavigerie Elodie Nouhaud Catherine Cattenoz Isabelle Martel-Lafay Catherine Terret Pascal Artru Pierre Clavere Achille Tchalla V éronique Vendrely Sophie Duc Source Type: research

Multi-domain neurocognitive impairment following definitive intensity-modulated radiotherapy for nasopharyngeal cancer: a cross-sectional study
CONCLUSIONS: Neurocognitive impairment is prevalent and profound in post-IMRT NPC survivors. Cognitive assessment and rehabilitation should be considered part of survivorship care.PMID:38341098 | DOI:10.1016/j.radonc.2024.110143 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 10, 2024 Category: Radiology Authors: James C H Chow Jack Lee Maria M P Lai Sara Li Adelina M C Lau Beni S Y Ng Gigi G G Leung Sharon T Y Li Jeffrey C F Lui K M Cheung K H Au K H Wong Alexander Y L Lau Benny C Y Zee Source Type: research

Diagnosis and management of pneumonitis following chemoradiotherapy and immunotherapy in stage III non-small cell lung cancer
CONCLUSIONS: In patients treated using the PACIFIC regimen, multidisciplinary assessment of CT-scans, radiation doses and patient symptoms, resulted in fewer diagnoses of immune-related pneumonitis (8.9%). Our study underscores the challenges in accurately diagnosing either IO-related or radiation pneumonitis in patients undergoing adjuvant immunotherapy after chemoradiotherapy and highlights the need for multidisciplinary review in order to avoid inappropriate cessation of adjuvant IO.PMID:38341099 | DOI:10.1016/j.radonc.2024.110147 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 10, 2024 Category: Radiology Authors: I Smesseim O M Mets J M A Daniels I Bahce S Senan Source Type: research

Shared decision making with breast cancer patients - does it work? Results of the cluster-randomized, multicenter DBCG RT SDM trial
CONCLUSION: Patient engagement in medical decision making was significantly improved with the use of an in-consultation patient decision aid compared to standard. The DH on adjuvant whole breast irradiation is now recommended as standard of care in the Danish guideline.PMID:38316191 | DOI:10.1016/j.radonc.2024.110115 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 5, 2024 Category: Radiology Authors: Stine Rauff S øndergaard Troels Bechmann Else Maae Anders W M ølby Nielsen Mette Holck Nielsen Mette M øller Signe Timm Ebbe Laugaard Lorenzen Leonard L Berry Robert Zachariae Birgitte Vrou Offersen Karina Dahl Steffensen Source Type: research

Common Sense (Radiation) Oncology: Redefining targets in radiotherapy
Radiother Oncol. 2024 Feb 3;193:110118. doi: 10.1016/j.radonc.2024.110118. Online ahead of print.ABSTRACTIn 2023, the Common Sense Oncology (CSO) movement was launched with the goal of recalibrating cancer care to focus on outcomes that matter to patients. We extend the three CSO pillars - evidence generation, interpretation and communication - to radiation oncology and advocate for better evidence demonstrating the value of our modality.PMID:38316192 | DOI:10.1016/j.radonc.2024.110118 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 5, 2024 Category: Radiology Authors: Nina N Sanford Yolande Lievens Ajay Aggarwal Timothy P Hanna Laura A Dawson Jeffrey White Bishal Gyawali Christopher Booth Fabio Ynoe de Moraes Source Type: research

Cost-effectiveness of weekly adaptive radiotherapy versus standard IMRT in head and neck cancer alongside the ARTIX trial
CONCLUSION: The ART strategy was deemed to be not cost-effective compared with standard IMRT for patients with locally advanced oropharyngeal cancer.PMID:38316193 | DOI:10.1016/j.radonc.2024.110116 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 5, 2024 Category: Radiology Authors: Lionel Perrier Fr édéric Balusson Magali Morelle Jo ël Castelli Juliette Thariat Karen Benezery Ali Hasbini Bernard Gery Antoine Berger Xavier Liem S ébastien Guihard Sophie Chapet S ébastien Thureau Pierre Auberdiac Pascal Pommier Amandine Ruffier A Source Type: research

Paediatric radiation therapy without anaesthesia - Are the children moving?
CONCLUSION: Children receiving RT with audiovisual distraction while awake had small magnitudes of observed intrafraction movement, with minimal movement in >97 % of observed RT fractions. This study validates methods of anaesthesia avoidance using audiovisual distraction for selected children.PMID:38311029 | DOI:10.1016/j.radonc.2024.110120 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 4, 2024 Category: Radiology Authors: Tatiana Ritchie Susan Awrey Manjula Maganti Rehab Chahin Michael Velec David C Hodgson Hitesh Dama Sameera Ahmed Jeff D Winter Normand Laperriere Derek S Tsang Source Type: research

Definitive single fraction spine stereotactic radiosurgery for metastatic sarcoma: Simultaneous integrated boost is associated with high tumor control and low vertebral fracture risk
CONCLUSION: This study represents one of the most homogenously treated and the largest cohorts of patients with SSM treated with single-fraction SSRS. Despite inherent radioresistance, SSRS confers durable and high rates of local control in SSM without unexpected long-term toxicity rates.PMID:38311030 | DOI:10.1016/j.radonc.2024.110119 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 4, 2024 Category: Radiology Authors: Mihir D Shanker Adriana P Cavazos Jing Li Thomas H Beckham Debra N Yeboa Chenyang Wang Mary Frances McAleer Tina Marie Briere Behrang Amini Claudio E Tatsui Robert Y North Christopher A Alvarez-Breckenridge Phillip Cem Cezayirli Laurence D Rhines Amol J G Source Type: research

Survival outcomes and toxicity of adjuvant immunotherapy after definitive concurrent chemotherapy with proton beam radiation therapy for patients with inoperable locally advanced non-small cell lung carcinoma
CONCLUSION: This study, one of the first to investigate CPBT followed by IO for inoperable LA-NSCLC, showed that IO conferred survival benefits with no increased rates of toxicity.PMID:38311031 | DOI:10.1016/j.radonc.2024.110121 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 4, 2024 Category: Radiology Authors: Kelsey L Corrigan Ting Xu Yuki Sasaki Ruitao Lin Aileen B Chen James W Welsh Steven H Lin Joe Y Chang Matthew S Ning Saumil Gandhi Michael S O'Reilly Carl M Gay Mehmet Altan Charles Lu Tina Cascone Efstratios Koutroumpakis Ajay Sheshadri Xiaodong Zhang Li Source Type: research

GEC-ESTRO survey of < sup > 106 < /sup > Ru eye applicator practice for ocular melanoma - Physicist survey
CONCLUSION: The physics survey showed a wide variability regarding quality control of the 106Ru sources and treatment planning practice.PMID:38309583 | DOI:10.1016/j.radonc.2024.110114 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 3, 2024 Category: Radiology Authors: Marisol De Brabandere Elisa Placidi Frank-Andr é Siebert Åsa Carlsson Tedgren Andrea Slocker Escarpa Luca Tagliaferri Michael Andr ássy Carmen Schulz Lotte S Fog Source Type: research

Application of postoperative adjuvant radiotherapy in limited-stage small cell lung cancer: A systematic review and meta-analysis
CONCLUSIONS: With respect to OS, PORT is not advisable in patients with pN0 or pN1 stage LS-SCLC but is highly recommended in pN2 stage LS-SCLC. Further research is warranted to confirm these findings.PMID:38309584 | DOI:10.1016/j.radonc.2024.110123 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 3, 2024 Category: Radiology Authors: Chuanhao Zhang Genghao Zhao Huajian Wu Jianing Jiang Wenyue Duan Zhijun Fan Zhe Wang Ruoyu Wang Source Type: research

Comprehensive insights on the underlying potential and advantage of proton therapy over intensity-modulated photon radiation therapy as highlighted in a wide real world data analysis
Radiother Oncol. 2024 Feb 1:110122. doi: 10.1016/j.radonc.2024.110122. Online ahead of print.NO ABSTRACTPMID:38309585 | DOI:10.1016/j.radonc.2024.110122 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 3, 2024 Category: Radiology Authors: Ester Orlandi Giulia Fontana Lisa Licitra Carmine Tinelli Anna Maria Camarda Cai Grau Steven Jay Frank Source Type: research

Magnetic resonance imaging for assessment of rectal cancer nodes after chemoradiotherapy: a single center experience
CONCLUSION: A reduction in size of 70% of the largest limph-node on MRI at rectal cancer restaging has high sensitivity and NPV for prediction of ypN0 stage after nCRT. The high NPV of node disappearance and of a ≤ 2.2 mm short-axis diameter is confirmed.PMID:38309586 | DOI:10.1016/j.radonc.2024.110124 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 3, 2024 Category: Radiology Authors: Brunella Barbaro Maria Rachele Pia Carafa Laura Maria Minordi Priscilla Testa Giulia Tatulli Davide Carano Claudio Fiorillo Giuditta Chiloiro Angela Romano Vincenzo Valentini Maria Antonietta Gambacorta Source Type: research

Disease and toxicity outcomes for a modern cohort of patients with squamous cell carcinoma of cutaneous origin involving the parotid gland: Comparison of volumetric modulated arc therapy and pencil beam scanning proton therapy
CONCLUSIONS: Cutaneous SCC involving the parotid can be an aggressive clinical entity despite modern multimodal therapy. PBT offers significantly lower dose to organs at risk compared to VMAT, which seemingly yields diminished acute toxicities.PMID:38309587 | DOI:10.1016/j.radonc.2024.110112 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 3, 2024 Category: Radiology Authors: Reza Zarinshenas Peter Campbell Kai Sun Jason K Molitoris Akshar N Patel Matthew E Witek Kevin J Cullen Ranee Mehra Kyle M Hatten Kelly F Moyer Rodney J Taylor Kalpesh T Vakharia Jeffrey S Wolf Matthew J Ferris Source Type: research