Dose-dependent changes in cardiac function, strain and remodelling in a preclinical model of heart base irradiation

CONCLUSIONS: Functional features of RICT displayed a BED dependence in this study. GLS showed an early change at 10 weeks post-irradiation. Cardiac remodelling was observed as increases in mass and volume of the LV, further supporting our hypothesis that dose to the base of the heart drives the global heart toxicity.PMID:38301958 | DOI:10.1016/j.radonc.2024.110113

Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 1, 2024 Category: Radiology Authors: Mihaela Ghita-Pettigrew Kevin S Edgar Refik Kuburas Kathryn H Brown Gerard M Walls Cecilia Facchi David J Grieve Chris J Watson Alan McWilliam Marcel van Herk Kaye J Williams Karl T Butterworth Source Type: research