Radio-chemotherapy of glioblastoma cells promotes phagocytosis by macrophages in vitro

CONCLUSIONS: and Perspectives We showed that macrophage phagocytic activity increased when exposed to supernatant from GBM cells treated by radio-chemotherapy. However, as efferocytosis-associated receptors were up-regulated, this effect could be deleterious for the anti-GBM immune response. We speculate that by inducing GBM cell apoptosis in parallel to an increase in efferocytosis receptor expression, the impact of radio-chemotherapy on phagocytic activity could promote anti-inflammatory and pro-tumoral TAM functions.PMID:38072365 | DOI:10.1016/j.radonc.2023.110049

Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 10, 2023 Category: Radiology Authors: Marc Lecoultre Sylvie Chliate Felipe I Espinoza Stoyan Tankov Val érie Dutoit Paul R Walker Source Type: research