Pelvic bone marrow dose-volume predictors of late lymphopenia following pelvic lymph node radiation therapy for prostate cancer

CONCLUSIONS: Two-year lymphopenia after PNI for PCa is largely modulated by baseline ALC, with an independent role of acute G3+ lymphopenia. BMLS-V24 was the best dosimetry predictor: constraints for BMTOT (V10Gy < 1520 cc, V20Gy < 1250 cc, V30Gy < 850 cc), and BMLS (V24y < 307 cc) were suggested to potentially reduce the risk.PMID:38503355 | DOI:10.1016/j.radonc.2024.110230

Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 19, 2024 Category: Radiology Authors: Maddalena Pavarini Lisa Alborghetti Stefania Aimonetto Angelo Maggio Valeria Landoni Paolo Ferrari Antonella Bianculli Edoardo Petrucci Alessandro Cicchetti Bruno Farina Maria Giulia Ubeira-Gabellini Paolo Salmoiraghi Eugenia Moretti Barbara Avuzzi Tommas Source Type: research