Trilobatin Induces Apoptosis and Attenuates Stemness Phenotype of Acquired Gefitinib Resistant Lung Cancer Cells via Suppression of NF- κB Pathway
In this study, MTT assays, EdU incorporation assays, DAPI staining, tumor sphere formation assays, immunofluorescent staining and Western blot analysis were performed to explore the functional role of trilobatin on gefitinib resistant lung cancer cells. The results showed that trilobatin inhibits proliferation of gefitinib resistant lung cancer cells. In addition, the proportions of apoptotic cells were increased along with down-regulated expression levels of Bcl-2 and mitochondrial Cytochrome C while up-regulated Bax, Cleaved Caspase-3, -9, and cytosolic Cytochrome C expression. Moreover, trilobatin decreased tumor sphere...
Source: Nutrition and Cancer - April 16, 2021 Category: Cancer & Oncology Authors: Wang Li Xu Zihan Wei Yizhe Liu Yanyang Li Zhixi Yan Xi Source Type: research

Trilobatin Induces Apoptosis and Attenuates Stemness Phenotype of Acquired Gefitinib Resistant Lung Cancer Cells via Suppression of NF- κB Pathway
In this study, MTT assays, EdU incorporation assays, DAPI staining, tumor sphere formation assays, immunofluorescent staining and Western blot analysis were performed to explore the functional role of trilobatin on gefitinib resistant lung cancer cells. The results showed that trilobatin inhibits proliferation of gefitinib resistant lung cancer cells. In addition, the proportions of apoptotic cells were increased along with down-regulated expression levels of Bcl-2 and mitochondrial Cytochrome C while up-regulated Bax, Cleaved Caspase-3, -9, and cytosolic Cytochrome C expression. Moreover, trilobatin decreased tumor sphere...
Source: Nutrition and Cancer - April 16, 2021 Category: Cancer & Oncology Authors: Wang Li Xu Zihan Wei Yizhe Liu Yanyang Li Zhixi Yan Xi Source Type: research

Trilobatin Induces Apoptosis and Attenuates Stemness Phenotype of Acquired Gefitinib Resistant Lung Cancer Cells via Suppression of NF- κB Pathway
. (Source: Nutrition and Cancer)
Source: Nutrition and Cancer - April 16, 2021 Category: Cancer & Oncology Authors: Wang Li Xu Zihan Wei Yizhe Liu Yanyang Li Zhixi Yan Xi Source Type: research

Emu Oil Attenuates Disease Severity and Results in Fewer Large Colonic Tumors in a Mouse Model of Colitis-Associated Colorectal Cancer
Nutr Cancer. 2021 Apr 12:1-10. doi: 10.1080/01635581.2021.1909737. Online ahead of print.ABSTRACTUlcerative colitis patients have an increased risk of developing colorectal cancer (CRC). The aim of the current study was to determine whether Emu Oil (EO) could reduce the severity of colitis, thereby inhibiting colitis-associated CRC (CA-CRC) development. Female C57BL/6 mice (n = 8/group) were injected (i.p.) with saline or azoxymethane (AOM) (7.4 mg/kg). Mice underwent three dextran sulfate sodium (DSS)/water cycles. Mice were orally-administered either water (160 µL) or EO (80 µL or 160 µL) thrice weekly ...
Source: Nutrition and Cancer - April 12, 2021 Category: Cancer & Oncology Authors: Suzanne Mashtoub Lauren C Chartier Debbie Trinder Ian C Lawrance Gordon S Howarth Source Type: research

A New Score for Quantifying Adherence to a Cancer-Preventive Mediterranean Diet
Nutr Cancer. 2021 Apr 10:1-13. doi: 10.1080/01635581.2021.1909738. Online ahead of print.ABSTRACTHerein a Mediterranean Cancer Preventive Diet Score (MCAP Score) is proposed to quantify adherence to both traditional Mediterranean fat intakes and the current dietary recommendations for cancer prevention. The scoring uses research-backed cutoff values, unlike other scores that are based on a population-specific median value. The MCAP score awards positive points for seven preventive food categories, including Mediterranean fats (monounsaturated fats, ω-3 fatty acids) associated with reduced adiposity, and negative poin...
Source: Nutrition and Cancer - April 12, 2021 Category: Cancer & Oncology Authors: Zora Djuric Samara Rifkin Source Type: research

Anti-Angiogenic Effect of < em > Cantharellus cibarius < /em > Extracts, its Correlation with Lipoxygenase Inhibition, and Role of the Bioactives Therein
Nutr Cancer. 2021 Apr 10:1-11. doi: 10.1080/01635581.2021.1909739. Online ahead of print.ABSTRACTAngiogenesis is a complex physiological process that cannot be treated with single agent therapy. Several edible fungi have been known to encompass bioactive compounds, and are promising sources of multi-component drugs. One such widely consumed edible fungi is Cantharellus cibarius, which has been explored for its biological activities. The present study focused on assessing the anti-angiogenic activity of petroleum ether and ethanol extracts of C. cibarius using chick chorioallantoic membrane (CAM) assay. Both the extracts sh...
Source: Nutrition and Cancer - April 12, 2021 Category: Cancer & Oncology Authors: Sandesh J Marathe Wahiba Hamzi Abdulla M Bashein Jan Deska Tuulikki Sepp änen-Laakso Rekha S Singhal Salem Shamekh Source Type: research

Emu Oil Attenuates Disease Severity and Results in Fewer Large Colonic Tumors in a Mouse Model of Colitis-Associated Colorectal Cancer
Nutr Cancer. 2021 Apr 12:1-10. doi: 10.1080/01635581.2021.1909737. Online ahead of print.ABSTRACTUlcerative colitis patients have an increased risk of developing colorectal cancer (CRC). The aim of the current study was to determine whether Emu Oil (EO) could reduce the severity of colitis, thereby inhibiting colitis-associated CRC (CA-CRC) development. Female C57BL/6 mice (n = 8/group) were injected (i.p.) with saline or azoxymethane (AOM) (7.4 mg/kg). Mice underwent three dextran sulfate sodium (DSS)/water cycles. Mice were orally-administered either water (160 µL) or EO (80 µL or 160 µL) thrice weekly ...
Source: Nutrition and Cancer - April 12, 2021 Category: Cancer & Oncology Authors: Suzanne Mashtoub Lauren C Chartier Debbie Trinder Ian C Lawrance Gordon S Howarth Source Type: research

A New Score for Quantifying Adherence to a Cancer-Preventive Mediterranean Diet
Nutr Cancer. 2021 Apr 10:1-13. doi: 10.1080/01635581.2021.1909738. Online ahead of print.ABSTRACTHerein a Mediterranean Cancer Preventive Diet Score (MCAP Score) is proposed to quantify adherence to both traditional Mediterranean fat intakes and the current dietary recommendations for cancer prevention. The scoring uses research-backed cutoff values, unlike other scores that are based on a population-specific median value. The MCAP score awards positive points for seven preventive food categories, including Mediterranean fats (monounsaturated fats, ω-3 fatty acids) associated with reduced adiposity, and negative poin...
Source: Nutrition and Cancer - April 12, 2021 Category: Cancer & Oncology Authors: Zora Djuric Samara Rifkin Source Type: research

Anti-Angiogenic Effect of < em > Cantharellus cibarius < /em > Extracts, its Correlation with Lipoxygenase Inhibition, and Role of the Bioactives Therein
Nutr Cancer. 2021 Apr 10:1-11. doi: 10.1080/01635581.2021.1909739. Online ahead of print.ABSTRACTAngiogenesis is a complex physiological process that cannot be treated with single agent therapy. Several edible fungi have been known to encompass bioactive compounds, and are promising sources of multi-component drugs. One such widely consumed edible fungi is Cantharellus cibarius, which has been explored for its biological activities. The present study focused on assessing the anti-angiogenic activity of petroleum ether and ethanol extracts of C. cibarius using chick chorioallantoic membrane (CAM) assay. Both the extracts sh...
Source: Nutrition and Cancer - April 12, 2021 Category: Cancer & Oncology Authors: Sandesh J Marathe Wahiba Hamzi Abdulla M Bashein Jan Deska Tuulikki Sepp änen-Laakso Rekha S Singhal Salem Shamekh Source Type: research

Emu Oil Attenuates Disease Severity and Results in Fewer Large Colonic Tumors in a Mouse Model of Colitis-Associated Colorectal Cancer
Nutr Cancer. 2021 Apr 12:1-10. doi: 10.1080/01635581.2021.1909737. Online ahead of print.ABSTRACTUlcerative colitis patients have an increased risk of developing colorectal cancer (CRC). The aim of the current study was to determine whether Emu Oil (EO) could reduce the severity of colitis, thereby inhibiting colitis-associated CRC (CA-CRC) development. Female C57BL/6 mice (n = 8/group) were injected (i.p.) with saline or azoxymethane (AOM) (7.4 mg/kg). Mice underwent three dextran sulfate sodium (DSS)/water cycles. Mice were orally-administered either water (160 µL) or EO (80 µL or 160 µL) thrice weekly ...
Source: Nutrition and Cancer - April 12, 2021 Category: Cancer & Oncology Authors: Suzanne Mashtoub Lauren C Chartier Debbie Trinder Ian C Lawrance Gordon S Howarth Source Type: research

A New Score for Quantifying Adherence to a Cancer-Preventive Mediterranean Diet
Nutr Cancer. 2021 Apr 10:1-13. doi: 10.1080/01635581.2021.1909738. Online ahead of print.ABSTRACTHerein a Mediterranean Cancer Preventive Diet Score (MCAP Score) is proposed to quantify adherence to both traditional Mediterranean fat intakes and the current dietary recommendations for cancer prevention. The scoring uses research-backed cutoff values, unlike other scores that are based on a population-specific median value. The MCAP score awards positive points for seven preventive food categories, including Mediterranean fats (monounsaturated fats, ω-3 fatty acids) associated with reduced adiposity, and negative poin...
Source: Nutrition and Cancer - April 12, 2021 Category: Cancer & Oncology Authors: Zora Djuric Samara Rifkin Source Type: research

Anti-Angiogenic Effect of < em > Cantharellus cibarius < /em > Extracts, its Correlation with Lipoxygenase Inhibition, and Role of the Bioactives Therein
Nutr Cancer. 2021 Apr 10:1-11. doi: 10.1080/01635581.2021.1909739. Online ahead of print.ABSTRACTAngiogenesis is a complex physiological process that cannot be treated with single agent therapy. Several edible fungi have been known to encompass bioactive compounds, and are promising sources of multi-component drugs. One such widely consumed edible fungi is Cantharellus cibarius, which has been explored for its biological activities. The present study focused on assessing the anti-angiogenic activity of petroleum ether and ethanol extracts of C. cibarius using chick chorioallantoic membrane (CAM) assay. Both the extracts sh...
Source: Nutrition and Cancer - April 12, 2021 Category: Cancer & Oncology Authors: Sandesh J Marathe Wahiba Hamzi Abdulla M Bashein Jan Deska Tuulikki Sepp änen-Laakso Rekha S Singhal Salem Shamekh Source Type: research

Emu Oil Attenuates Disease Severity and Results in Fewer Large Colonic Tumors in a Mouse Model of Colitis-Associated Colorectal Cancer
Nutr Cancer. 2021 Apr 12:1-10. doi: 10.1080/01635581.2021.1909737. Online ahead of print.ABSTRACTUlcerative colitis patients have an increased risk of developing colorectal cancer (CRC). The aim of the current study was to determine whether Emu Oil (EO) could reduce the severity of colitis, thereby inhibiting colitis-associated CRC (CA-CRC) development. Female C57BL/6 mice (n = 8/group) were injected (i.p.) with saline or azoxymethane (AOM) (7.4 mg/kg). Mice underwent three dextran sulfate sodium (DSS)/water cycles. Mice were orally-administered either water (160 µL) or EO (80 µL or 160 µL) thrice weekly ...
Source: Nutrition and Cancer - April 12, 2021 Category: Cancer & Oncology Authors: Suzanne Mashtoub Lauren C Chartier Debbie Trinder Ian C Lawrance Gordon S Howarth Source Type: research

A New Score for Quantifying Adherence to a Cancer-Preventive Mediterranean Diet
Nutr Cancer. 2021 Apr 10:1-13. doi: 10.1080/01635581.2021.1909738. Online ahead of print.ABSTRACTHerein a Mediterranean Cancer Preventive Diet Score (MCAP Score) is proposed to quantify adherence to both traditional Mediterranean fat intakes and the current dietary recommendations for cancer prevention. The scoring uses research-backed cutoff values, unlike other scores that are based on a population-specific median value. The MCAP score awards positive points for seven preventive food categories, including Mediterranean fats (monounsaturated fats, ω-3 fatty acids) associated with reduced adiposity, and negative poin...
Source: Nutrition and Cancer - April 12, 2021 Category: Cancer & Oncology Authors: Zora Djuric Samara Rifkin Source Type: research

Anti-Angiogenic Effect of < em > Cantharellus cibarius < /em > Extracts, its Correlation with Lipoxygenase Inhibition, and Role of the Bioactives Therein
Nutr Cancer. 2021 Apr 10:1-11. doi: 10.1080/01635581.2021.1909739. Online ahead of print.ABSTRACTAngiogenesis is a complex physiological process that cannot be treated with single agent therapy. Several edible fungi have been known to encompass bioactive compounds, and are promising sources of multi-component drugs. One such widely consumed edible fungi is Cantharellus cibarius, which has been explored for its biological activities. The present study focused on assessing the anti-angiogenic activity of petroleum ether and ethanol extracts of C. cibarius using chick chorioallantoic membrane (CAM) assay. Both the extracts sh...
Source: Nutrition and Cancer - April 12, 2021 Category: Cancer & Oncology Authors: Sandesh J Marathe Wahiba Hamzi Abdulla M Bashein Jan Deska Tuulikki Sepp änen-Laakso Rekha S Singhal Salem Shamekh Source Type: research

Emu Oil Attenuates Disease Severity and Results in Fewer Large Colonic Tumors in a Mouse Model of Colitis-Associated Colorectal Cancer
. (Source: Nutrition and Cancer)
Source: Nutrition and Cancer - April 12, 2021 Category: Cancer & Oncology Authors: Suzanne Mashtoub Lauren C. Chartier Debbie Trinder Ian C. Lawrance Gordon S. Howarth Source Type: research

Anti-Angiogenic Effect of Cantharellus cibarius Extracts, its Correlation with Lipoxygenase Inhibition, and Role of the Bioactives Therein
. (Source: Nutrition and Cancer)
Source: Nutrition and Cancer - April 10, 2021 Category: Cancer & Oncology Authors: Sandesh J. Marathe Wahiba Hamzi Abdulla M. Bashein Jan Deska Tuulikki Sepp änen-Laakso Rekha S. Singhal Salem Shamekh Source Type: research

A New Score for Quantifying Adherence to a Cancer-Preventive Mediterranean Diet
. (Source: Nutrition and Cancer)
Source: Nutrition and Cancer - April 10, 2021 Category: Cancer & Oncology Authors: Zora Djuric Samara Rifkin Source Type: research

Preventive Effect of Combined < em > Zingiber officinale < /em > and < em > Terminalia chebula < /em > against DMBA-Induced Breast Cancer Rats < em > via < /em > mTOR Inhibition
In conclusion, the results obtained suggest that ZOTC can suppress tumor progression in DMBA-induced breast cancer rats via inhibition of the mTOR pathway.PMID:33821702 | DOI:10.1080/01635581.2021.1903948 (Source: Nutrition and Cancer)
Source: Nutrition and Cancer - April 6, 2021 Category: Cancer & Oncology Authors: Jayasindu Mathiyazhagan Ramamoorthy Siva Rama Jayaraj Harishkumar Madhyastha Gothandam Kodiveri Muthukaliannan Source Type: research

Preventive Effect of Combined < em > Zingiber officinale < /em > and < em > Terminalia chebula < /em > against DMBA-Induced Breast Cancer Rats < em > via < /em > mTOR Inhibition
In conclusion, the results obtained suggest that ZOTC can suppress tumor progression in DMBA-induced breast cancer rats via inhibition of the mTOR pathway.PMID:33821702 | DOI:10.1080/01635581.2021.1903948 (Source: Nutrition and Cancer)
Source: Nutrition and Cancer - April 6, 2021 Category: Cancer & Oncology Authors: Jayasindu Mathiyazhagan Ramamoorthy Siva Rama Jayaraj Harishkumar Madhyastha Gothandam Kodiveri Muthukaliannan Source Type: research

Preventive Effect of Combined < em > Zingiber officinale < /em > and < em > Terminalia chebula < /em > against DMBA-Induced Breast Cancer Rats < em > via < /em > mTOR Inhibition
In conclusion, the results obtained suggest that ZOTC can suppress tumor progression in DMBA-induced breast cancer rats via inhibition of the mTOR pathway.PMID:33821702 | DOI:10.1080/01635581.2021.1903948 (Source: Nutrition and Cancer)
Source: Nutrition and Cancer - April 6, 2021 Category: Cancer & Oncology Authors: Jayasindu Mathiyazhagan Ramamoorthy Siva Rama Jayaraj Harishkumar Madhyastha Gothandam Kodiveri Muthukaliannan Source Type: research

Preventive Effect of Combined < em > Zingiber officinale < /em > and < em > Terminalia chebula < /em > against DMBA-Induced Breast Cancer Rats < em > via < /em > mTOR Inhibition
In conclusion, the results obtained suggest that ZOTC can suppress tumor progression in DMBA-induced breast cancer rats via inhibition of the mTOR pathway.PMID:33821702 | DOI:10.1080/01635581.2021.1903948 (Source: Nutrition and Cancer)
Source: Nutrition and Cancer - April 6, 2021 Category: Cancer & Oncology Authors: Jayasindu Mathiyazhagan Ramamoorthy Siva Rama Jayaraj Harishkumar Madhyastha Gothandam Kodiveri Muthukaliannan Source Type: research

Preventive Effect of Combined < em > Zingiber officinale < /em > and < em > Terminalia chebula < /em > against DMBA-Induced Breast Cancer Rats < em > via < /em > mTOR Inhibition
In conclusion, the results obtained suggest that ZOTC can suppress tumor progression in DMBA-induced breast cancer rats via inhibition of the mTOR pathway.PMID:33821702 | DOI:10.1080/01635581.2021.1903948 (Source: Nutrition and Cancer)
Source: Nutrition and Cancer - April 6, 2021 Category: Cancer & Oncology Authors: Jayasindu Mathiyazhagan Ramamoorthy Siva Rama Jayaraj Harishkumar Madhyastha Gothandam Kodiveri Muthukaliannan Source Type: research

Preventive Effect of Combined Zingiber officinale and Terminalia chebula against DMBA-Induced Breast Cancer Rats via mTOR Inhibition
. (Source: Nutrition and Cancer)
Source: Nutrition and Cancer - April 6, 2021 Category: Cancer & Oncology Authors: Jayasindu Mathiyazhagan Ramamoorthy Siva Rama Jayaraj Harishkumar Madhyastha Gothandam Kodiveri Muthukaliannan Source Type: research

Effect of Hesperidin against Induced Colon Cancer in Rats: Impact of Smad4 and Activin A Signaling Pathway
CONCLUSION: This study demonstrated the chemopreventive effect of Hsd against CRC by modulating Smad4 and activin A signaling in vivo. Further studies are needed to demonstrate its clinical value and explore its possible role in advanced malignancy.PMID:33818196 | DOI:10.1080/01635581.2021.1907424 (Source: Nutrition and Cancer)
Source: Nutrition and Cancer - April 5, 2021 Category: Cancer & Oncology Authors: Sahar E M El-Deek Sary K H Abd-Elghaffar Randa S Hna Heba G Mohamed Heba E M El-Deek Source Type: research

Effect of Hesperidin against Induced Colon Cancer in Rats: Impact of Smad4 and Activin A Signaling Pathway
CONCLUSION: This study demonstrated the chemopreventive effect of Hsd against CRC by modulating Smad4 and activin A signaling in vivo. Further studies are needed to demonstrate its clinical value and explore its possible role in advanced malignancy.PMID:33818196 | DOI:10.1080/01635581.2021.1907424 (Source: Nutrition and Cancer)
Source: Nutrition and Cancer - April 5, 2021 Category: Cancer & Oncology Authors: Sahar E M El-Deek Sary K H Abd-Elghaffar Randa S Hna Heba G Mohamed Heba E M El-Deek Source Type: research

Effect of Hesperidin against Induced Colon Cancer in Rats: Impact of Smad4 and Activin A Signaling Pathway
. (Source: Nutrition and Cancer)
Source: Nutrition and Cancer - April 5, 2021 Category: Cancer & Oncology Authors: Sahar E. M. El-Deek Sary K. H. Abd-Elghaffar Randa S. Hna Heba G. Mohamed Heba E. M. El-Deek Source Type: research

Randomized, Placebo-Controlled Six-Month Intervention Study of Soy Protein Isolate in Men with Biochemical Recurrence after Radical Prostatectomy: A Pilot Study
We examined the effect of 6-8 mo soy protein supplementation on prostate specific antigen (PSA) serum levels in men who recurred (PSA> 0.1 ng/ml) within three years of prostatectomy. Sixteen men were randomized to 20 g soy protein (∼24-26/day genistein; ∼40-43/day total isoflavones) or casein placebo. PSA was measured at base line and at 1, 2, 4, and 6-8 mo. Serum genistein levels greatly increased from baseline and cholesterol decreased in the soy group. In both treatment arms PSA increased similarly and PSA doubling times were not different over the 6-8 mo study duration. Two subjects in each group had stable ...
Source: Nutrition and Cancer - March 25, 2021 Category: Cancer & Oncology Authors: Maarten C Bosland Joanne Schmoll Hiroko Watanabe Carla Randolph Ikuko Kato Source Type: research

Randomized, Placebo-Controlled Six-Month Intervention Study of Soy Protein Isolate in Men with Biochemical Recurrence after Radical Prostatectomy: A Pilot Study
We examined the effect of 6-8 mo soy protein supplementation on prostate specific antigen (PSA) serum levels in men who recurred (PSA> 0.1 ng/ml) within three years of prostatectomy. Sixteen men were randomized to 20 g soy protein (∼24-26/day genistein; ∼40-43/day total isoflavones) or casein placebo. PSA was measured at base line and at 1, 2, 4, and 6-8 mo. Serum genistein levels greatly increased from baseline and cholesterol decreased in the soy group. In both treatment arms PSA increased similarly and PSA doubling times were not different over the 6-8 mo study duration. Two subjects in each group had stable ...
Source: Nutrition and Cancer - March 25, 2021 Category: Cancer & Oncology Authors: Maarten C Bosland Joanne Schmoll Hiroko Watanabe Carla Randolph Ikuko Kato Source Type: research

Randomized, Placebo-Controlled Six-Month Intervention Study of Soy Protein Isolate in Men with Biochemical Recurrence after Radical Prostatectomy: A Pilot Study
We examined the effect of 6-8 mo soy protein supplementation on prostate specific antigen (PSA) serum levels in men who recurred (PSA> 0.1 ng/ml) within three years of prostatectomy. Sixteen men were randomized to 20 g soy protein (∼24-26/day genistein; ∼40-43/day total isoflavones) or casein placebo. PSA was measured at base line and at 1, 2, 4, and 6-8 mo. Serum genistein levels greatly increased from baseline and cholesterol decreased in the soy group. In both treatment arms PSA increased similarly and PSA doubling times were not different over the 6-8 mo study duration. Two subjects in each group had stable ...
Source: Nutrition and Cancer - March 25, 2021 Category: Cancer & Oncology Authors: Maarten C Bosland Joanne Schmoll Hiroko Watanabe Carla Randolph Ikuko Kato Source Type: research

Randomized, Placebo-Controlled Six-Month Intervention Study of Soy Protein Isolate in Men with Biochemical Recurrence after Radical Prostatectomy: A Pilot Study
We examined the effect of 6-8 mo soy protein supplementation on prostate specific antigen (PSA) serum levels in men who recurred (PSA> 0.1 ng/ml) within three years of prostatectomy. Sixteen men were randomized to 20 g soy protein (∼24-26/day genistein; ∼40-43/day total isoflavones) or casein placebo. PSA was measured at base line and at 1, 2, 4, and 6-8 mo. Serum genistein levels greatly increased from baseline and cholesterol decreased in the soy group. In both treatment arms PSA increased similarly and PSA doubling times were not different over the 6-8 mo study duration. Two subjects in each group had stable ...
Source: Nutrition and Cancer - March 25, 2021 Category: Cancer & Oncology Authors: Maarten C Bosland Joanne Schmoll Hiroko Watanabe Carla Randolph Ikuko Kato Source Type: research

Randomized, Placebo-Controlled Six-Month Intervention Study of Soy Protein Isolate in Men with Biochemical Recurrence after Radical Prostatectomy: A Pilot Study
We examined the effect of 6-8 mo soy protein supplementation on prostate specific antigen (PSA) serum levels in men who recurred (PSA> 0.1 ng/ml) within three years of prostatectomy. Sixteen men were randomized to 20 g soy protein (∼24-26/day genistein; ∼40-43/day total isoflavones) or casein placebo. PSA was measured at base line and at 1, 2, 4, and 6-8 mo. Serum genistein levels greatly increased from baseline and cholesterol decreased in the soy group. In both treatment arms PSA increased similarly and PSA doubling times were not different over the 6-8 mo study duration. Two subjects in each group had stable ...
Source: Nutrition and Cancer - March 25, 2021 Category: Cancer & Oncology Authors: Maarten C Bosland Joanne Schmoll Hiroko Watanabe Carla Randolph Ikuko Kato Source Type: research

Randomized, Placebo-Controlled Six-Month Intervention Study of Soy Protein Isolate in Men with Biochemical Recurrence after Radical Prostatectomy: A Pilot Study
We examined the effect of 6-8 mo soy protein supplementation on prostate specific antigen (PSA) serum levels in men who recurred (PSA> 0.1 ng/ml) within three years of prostatectomy. Sixteen men were randomized to 20 g soy protein (∼24-26/day genistein; ∼40-43/day total isoflavones) or casein placebo. PSA was measured at base line and at 1, 2, 4, and 6-8 mo. Serum genistein levels greatly increased from baseline and cholesterol decreased in the soy group. In both treatment arms PSA increased similarly and PSA doubling times were not different over the 6-8 mo study duration. Two subjects in each group had stable ...
Source: Nutrition and Cancer - March 25, 2021 Category: Cancer & Oncology Authors: Maarten C Bosland Joanne Schmoll Hiroko Watanabe Carla Randolph Ikuko Kato Source Type: research

Randomized, Placebo-Controlled Six-Month Intervention Study of Soy Protein Isolate in Men with Biochemical Recurrence after Radical Prostatectomy: A Pilot Study
We examined the effect of 6-8 mo soy protein supplementation on prostate specific antigen (PSA) serum levels in men who recurred (PSA> 0.1 ng/ml) within three years of prostatectomy. Sixteen men were randomized to 20 g soy protein (∼24-26/day genistein; ∼40-43/day total isoflavones) or casein placebo. PSA was measured at base line and at 1, 2, 4, and 6-8 mo. Serum genistein levels greatly increased from baseline and cholesterol decreased in the soy group. In both treatment arms PSA increased similarly and PSA doubling times were not different over the 6-8 mo study duration. Two subjects in each group had stable ...
Source: Nutrition and Cancer - March 25, 2021 Category: Cancer & Oncology Authors: Maarten C Bosland Joanne Schmoll Hiroko Watanabe Carla Randolph Ikuko Kato Source Type: research

Randomized, Placebo-Controlled Six-Month Intervention Study of Soy Protein Isolate in Men with Biochemical Recurrence after Radical Prostatectomy: A Pilot Study
We examined the effect of 6-8 mo soy protein supplementation on prostate specific antigen (PSA) serum levels in men who recurred (PSA> 0.1 ng/ml) within three years of prostatectomy. Sixteen men were randomized to 20 g soy protein (∼24-26/day genistein; ∼40-43/day total isoflavones) or casein placebo. PSA was measured at base line and at 1, 2, 4, and 6-8 mo. Serum genistein levels greatly increased from baseline and cholesterol decreased in the soy group. In both treatment arms PSA increased similarly and PSA doubling times were not different over the 6-8 mo study duration. Two subjects in each group had stable ...
Source: Nutrition and Cancer - March 25, 2021 Category: Cancer & Oncology Authors: Maarten C Bosland Joanne Schmoll Hiroko Watanabe Carla Randolph Ikuko Kato Source Type: research

Randomized, Placebo-Controlled Six-Month Intervention Study of Soy Protein Isolate in Men with Biochemical Recurrence after Radical Prostatectomy: A Pilot Study
We examined the effect of 6-8 mo soy protein supplementation on prostate specific antigen (PSA) serum levels in men who recurred (PSA> 0.1 ng/ml) within three years of prostatectomy. Sixteen men were randomized to 20 g soy protein (∼24-26/day genistein; ∼40-43/day total isoflavones) or casein placebo. PSA was measured at base line and at 1, 2, 4, and 6-8 mo. Serum genistein levels greatly increased from baseline and cholesterol decreased in the soy group. In both treatment arms PSA increased similarly and PSA doubling times were not different over the 6-8 mo study duration. Two subjects in each group had stable ...
Source: Nutrition and Cancer - March 25, 2021 Category: Cancer & Oncology Authors: Maarten C Bosland Joanne Schmoll Hiroko Watanabe Carla Randolph Ikuko Kato Source Type: research

Randomized, Placebo-Controlled Six-Month Intervention Study of Soy Protein Isolate in Men with Biochemical Recurrence after Radical Prostatectomy: A Pilot Study
. (Source: Nutrition and Cancer)
Source: Nutrition and Cancer - March 25, 2021 Category: Cancer & Oncology Authors: Maarten C. Bosland Joanne Schmoll Hiroko Watanabe Carla Randolph Ikuko Kato Source Type: research

Changes in Serum, Red Blood Cell, and Colonic Fatty Acids in a Personalized Omega-3 Fatty Acid Supplementation Trial
This study evaluated changes in fatty acids from sera, red blood cells, and colonic biopsies from a phase Ib clinical trial of personalized ω-3 fatty acid dosing in 47 healthy volunteers. The trial aimed to reduce colonic prostaglandin E2 (PGE2), a pro-inflammatory product of arachidonic acid (AA) oxidation. The personalized doses ranged 2-10 grams/day (54% eicosapentaenoic acid, EPA, 24% other ω-3 fatty acids). In colon, increases in ω-3 highly unsaturated fatty acids (HUFA) and EPA:AA ratios each were correlated with decreases in PGE2. Changes in either colonic EPA:AA ratios or ω-3 HUFA were signi...
Source: Nutrition and Cancer - March 24, 2021 Category: Cancer & Oncology Authors: Yifan Shen Ananda Sen D Kim Turgeon Jianwei Ren Gillian Graifman Mack T Ruffin William L Smith Dean E Brenner Zora Djuric Source Type: research

Luteolin Induces Apoptosis and Autophagy in HCT116 Colon Cancer Cells via p53-Dependent Pathway
In conclusion, the present data showed that luteolin inhibits the growth of HCT116 colon cancer cells through p53-dependent regulation of apoptosis and cell cycle arrest regardless of the induction of autophagy.PMID:33757400 | DOI:10.1080/01635581.2021.1903947 (Source: Nutrition and Cancer)
Source: Nutrition and Cancer - March 24, 2021 Category: Cancer & Oncology Authors: Ho Soo Yoo Sae Bom Won Young Hye Kwon Source Type: research

Changes in Serum, Red Blood Cell, and Colonic Fatty Acids in a Personalized Omega-3 Fatty Acid Supplementation Trial
This study evaluated changes in fatty acids from sera, red blood cells, and colonic biopsies from a phase Ib clinical trial of personalized ω-3 fatty acid dosing in 47 healthy volunteers. The trial aimed to reduce colonic prostaglandin E2 (PGE2), a pro-inflammatory product of arachidonic acid (AA) oxidation. The personalized doses ranged 2-10 grams/day (54% eicosapentaenoic acid, EPA, 24% other ω-3 fatty acids). In colon, increases in ω-3 highly unsaturated fatty acids (HUFA) and EPA:AA ratios each were correlated with decreases in PGE2. Changes in either colonic EPA:AA ratios or ω-3 HUFA were signi...
Source: Nutrition and Cancer - March 24, 2021 Category: Cancer & Oncology Authors: Yifan Shen Ananda Sen D Kim Turgeon Jianwei Ren Gillian Graifman Mack T Ruffin William L Smith Dean E Brenner Zora Djuric Source Type: research

Luteolin Induces Apoptosis and Autophagy in HCT116 Colon Cancer Cells via p53-Dependent Pathway
In conclusion, the present data showed that luteolin inhibits the growth of HCT116 colon cancer cells through p53-dependent regulation of apoptosis and cell cycle arrest regardless of the induction of autophagy.PMID:33757400 | DOI:10.1080/01635581.2021.1903947 (Source: Nutrition and Cancer)
Source: Nutrition and Cancer - March 24, 2021 Category: Cancer & Oncology Authors: Ho Soo Yoo Sae Bom Won Young Hye Kwon Source Type: research

Changes in Serum, Red Blood Cell, and Colonic Fatty Acids in a Personalized Omega-3 Fatty Acid Supplementation Trial
. (Source: Nutrition and Cancer)
Source: Nutrition and Cancer - March 24, 2021 Category: Cancer & Oncology Authors: Yifan Shen Ananda Sen D. Kim Turgeon Jianwei Ren Gillian Graifman Mack T. Ruffin William L. Smith Dean E. Brenner Zora Djuric Source Type: research

Luteolin Induces Apoptosis and Autophagy in HCT116 Colon Cancer Cells via p53-Dependent Pathway
. (Source: Nutrition and Cancer)
Source: Nutrition and Cancer - March 24, 2021 Category: Cancer & Oncology Authors: Ho Soo Yoo Sae Bom Won Young Hye Kwon Source Type: research

Impact of Body Weight Loss on Survival in Patients with Advanced Gastric Cancer Receiving Second-Line Treatment
Nutr Cancer. 2021 Mar 23:1-14. doi: 10.1080/01635581.2021.1902542. Online ahead of print.ABSTRACTLimited information is available regarding the impact of body weight loss (BWL) in patients with advanced gastric cancer (AGC) who receive second-line chemotherapy. We retrospectively reviewed data for consecutive AGC patients who received second-line treatment with taxane-based chemotherapy at our institution between January 2014 and September 2018. We calculated variables, including percent BWL per month during chemotherapy (%BWL/m), and analyzed the correlations between BWL and other clinicopathological parameters with survi...
Source: Nutrition and Cancer - March 23, 2021 Category: Cancer & Oncology Authors: Takuro Mizukami Koki Hamaji Risa Onuki Ayako Yokomizo Yoshie Nagashima Hiroyuki Takeda Kumiko Umemoto Ayako Doi Hiroyuki Arai Mami Hirakawa Yoshiki Horie Naoki Izawa Takashi Ogura Takashi Tsuda Yu Sunakawa Michi Shibata Tsuneaki Tanaka Shinya Mikami Takak Source Type: research

Impact of Body Weight Loss on Survival in Patients with Advanced Gastric Cancer Receiving Second-Line Treatment
. (Source: Nutrition and Cancer)
Source: Nutrition and Cancer - March 23, 2021 Category: Cancer & Oncology Authors: Takuro Mizukami Koki Hamaji Risa Onuki Ayako Yokomizo Yoshie Nagashima Hiroyuki Takeda Kumiko Umemoto Ayako Doi Hiroyuki Arai Mami Hirakawa Yoshiki Horie Naoki Izawa Takashi Ogura Takashi Tsuda Yu Sunakawa Michi Shibata Tsuneaki Tanaka Shinya Mikami Takak Source Type: research

Association of Weight Change, Inflammation Markers and Disease Staging with Survival of Patients Undergoing Chemotherapy for Pancreatic Adenocarcinoma
Nutr Cancer. 2021 Mar 22:1-10. doi: 10.1080/01635581.2021.1903049. Online ahead of print.ABSTRACTINTRODUCTION: Cancer-associated-cachexia represents a systemic syndrome of unintended weight-loss (WL) and systemic inflammation, affecting>80% patients with pancreatic adenocarcinoma (PA). We aimed to evaluate the association of weight change (WC) with survival of patients treated with chemotherapy (ChT) for PA and the influence of disease staging. We also studied the prognostic and predictive value of inflammation-based scores.METHODS: Observational, retrospective cohort study. Individuals were divided into two cohorts, ac...
Source: Nutrition and Cancer - March 22, 2021 Category: Cancer & Oncology Authors: Leonor Vasconcelos de Matos Andreia Coelho Renato Cunha Leonor Fernandes M ário Fontes E Sousa Maria Teresa Neves D ébora Cardoso Mariana Malheiro Joana Gra ça Eug énia Santos Silva Ana Pl ácido Ana Martins Source Type: research

Association of Weight Change, Inflammation Markers and Disease Staging with Survival of Patients Undergoing Chemotherapy for Pancreatic Adenocarcinoma
Nutr Cancer. 2021 Mar 22:1-10. doi: 10.1080/01635581.2021.1903049. Online ahead of print.ABSTRACTINTRODUCTION: Cancer-associated-cachexia represents a systemic syndrome of unintended weight-loss (WL) and systemic inflammation, affecting>80% patients with pancreatic adenocarcinoma (PA). We aimed to evaluate the association of weight change (WC) with survival of patients treated with chemotherapy (ChT) for PA and the influence of disease staging. We also studied the prognostic and predictive value of inflammation-based scores.METHODS: Observational, retrospective cohort study. Individuals were divided into two cohorts, ac...
Source: Nutrition and Cancer - March 22, 2021 Category: Cancer & Oncology Authors: Leonor Vasconcelos de Matos Andreia Coelho Renato Cunha Leonor Fernandes M ário Fontes E Sousa Maria Teresa Neves D ébora Cardoso Mariana Malheiro Joana Gra ça Eug énia Santos Silva Ana Pl ácido Ana Martins Source Type: research

Association of Weight Change, Inflammation Markers and Disease Staging with Survival of Patients Undergoing Chemotherapy for Pancreatic Adenocarcinoma
. (Source: Nutrition and Cancer)
Source: Nutrition and Cancer - March 22, 2021 Category: Cancer & Oncology Authors: Leonor Vasconcelos de Matos Andreia Coelho Renato Cunha Leonor Fernandes M ário Fontes e Sousa Maria Teresa Neves D ébora Cardoso Mariana Malheiro Joana Gra ça Eug énia Santos Silva Ana Pl ácido Ana Martins Source Type: research

Frequency of Body Weight Loss is an Independent Prognostic Factor of First-Line Treatment Outcomes in Metastatic Colorectal Cancer
Nutr Cancer. 2021 Mar 19:1-7. doi: 10.1080/01635581.2021.1900300. Online ahead of print.ABSTRACTOne of the main features of wasting in cancer is an involuntary weight loss which is most pronounced in gastrointestinal tract tumors and leads to worse clinical outcomes. The aim of this study is to analyze the frequency of body weight loss (FBWL) as an additional prognostic factor in the treatment of patients with metastatic colorectal cancer (mCRC).In this observational, single-center study, data were retrieved for 236 patients treated for mCRC. FBWL was defined as a percent of change in weight divided by weeks of therapy. Pa...
Source: Nutrition and Cancer - March 19, 2021 Category: Cancer & Oncology Authors: Juraj Prejac Domina Kekez Borislav Belev Marija Prejac Stjepko Ple ština Source Type: research

Frequency of Body Weight Loss is an Independent Prognostic Factor of First-Line Treatment Outcomes in Metastatic Colorectal Cancer
Nutr Cancer. 2021 Mar 19:1-7. doi: 10.1080/01635581.2021.1900300. Online ahead of print.ABSTRACTOne of the main features of wasting in cancer is an involuntary weight loss which is most pronounced in gastrointestinal tract tumors and leads to worse clinical outcomes. The aim of this study is to analyze the frequency of body weight loss (FBWL) as an additional prognostic factor in the treatment of patients with metastatic colorectal cancer (mCRC).In this observational, single-center study, data were retrieved for 236 patients treated for mCRC. FBWL was defined as a percent of change in weight divided by weeks of therapy. Pa...
Source: Nutrition and Cancer - March 19, 2021 Category: Cancer & Oncology Authors: Juraj Prejac Domina Kekez Borislav Belev Marija Prejac Stjepko Ple ština Source Type: research