Bringing Clarity to the Murky Problem of Cardiac Allograft Vasculopathy
Am J Pathol. 2022 May 13:S0002-9440(22)00143-2. doi: 10.1016/j.ajpath.2022.05.002. Online ahead of print.NO ABSTRACTPMID:35577009 | DOI:10.1016/j.ajpath.2022.05.002 (Source: Am J Pathol)
Source: Am J Pathol - May 16, 2022 Category: Pathology Authors: Ronald G Gill Source Type: research

This Month in AJP
Am J Pathol. 2022 May 11:S0002-9440(22)00144-4. doi: 10.1016/j.ajpath.2022.05.001. Online ahead of print.NO ABSTRACTPMID:35568108 | PMC:PMC9095256 | DOI:10.1016/j.ajpath.2022.05.001 (Source: Am J Pathol)
Source: Am J Pathol - May 14, 2022 Category: Pathology Authors: Chhavi Chauhan Source Type: research

This Month in AJP
Am J Pathol. 2022 May 11:S0002-9440(22)00144-4. doi: 10.1016/j.ajpath.2022.05.001. Online ahead of print.NO ABSTRACTPMID:35568108 | PMC:PMC9095256 | DOI:10.1016/j.ajpath.2022.05.001 (Source: Am J Pathol)
Source: Am J Pathol - May 14, 2022 Category: Pathology Authors: Chhavi Chauhan Source Type: research

Molecular Signature of Antibody-Mediated Chronic Vasculopathy in Heart Allografts in a Novel Mouse Model
In conclusion, these findings report a novel model of antibody-mediated CAV that will facilitate further understanding of the molecular mechanisms promoting development of CAV.PMID:35490714 | DOI:10.1016/j.ajpath.2022.04.003 (Source: Am J Pathol)
Source: Am J Pathol - May 1, 2022 Category: Pathology Authors: Hidetoshi Tsuda Nina Dvorina Karen S Keslar Jessica Nevarez-Mejia Nicole M Valenzuela Elaine F Reed Robert L Fairchild William M Baldwin Source Type: research

Hepatic Protein and Phosphoprotein Signatures of Alcohol-Associated Cirrhosis and Hepatitis
Am J Pathol. 2022 Apr 28:S0002-9440(22)00121-3. doi: 10.1016/j.ajpath.2022.04.004. Online ahead of print.ABSTRACTAlcohol-associated liver disease is a global health care burden, with alcohol-associated cirrhosis (AC) and hepatitis (AH) being two clinical manifestations with poor prognosis. The limited efficacy of standard care for AC and AH highlights a need for therapeutic targets and strategies. The current study aimed to address this need through the identification of hepatic proteome and phosphoproteome signatures of AC and AH. Proteomic and phosphoproteomic analyses were conducted on explant liver tissue (test cohort)...
Source: Am J Pathol - May 1, 2022 Category: Pathology Authors: Josiah Hardesty Le Day Jeffrey Warner Dennis Warner Marina Gritsenko Aliya Asghar Andrew Stolz Timothy Morgan Craig McClain Jon Jacobs Irina Kirpich Source Type: research

Molecular Signature of Antibody-Mediated Chronic Vasculopathy in Heart Allografts in a Novel Mouse Model
In conclusion, these findings report a novel model of antibody-mediated CAV that will facilitate further understanding of the molecular mechanisms promoting development of CAV.PMID:35490714 | DOI:10.1016/j.ajpath.2022.04.003 (Source: Am J Pathol)
Source: Am J Pathol - May 1, 2022 Category: Pathology Authors: Hidetoshi Tsuda Nina Dvorina Karen S Keslar Jessica Nevarez-Mejia Nicole M Valenzuela Elaine F Reed Robert L Fairchild William M Baldwin Source Type: research

Hepatic Protein and Phosphoprotein Signatures of Alcohol-Associated Cirrhosis and Hepatitis
Am J Pathol. 2022 Apr 28:S0002-9440(22)00121-3. doi: 10.1016/j.ajpath.2022.04.004. Online ahead of print.ABSTRACTAlcohol-associated liver disease is a global health care burden, with alcohol-associated cirrhosis (AC) and hepatitis (AH) being two clinical manifestations with poor prognosis. The limited efficacy of standard care for AC and AH highlights a need for therapeutic targets and strategies. The current study aimed to address this need through the identification of hepatic proteome and phosphoproteome signatures of AC and AH. Proteomic and phosphoproteomic analyses were conducted on explant liver tissue (test cohort)...
Source: Am J Pathol - May 1, 2022 Category: Pathology Authors: Josiah Hardesty Le Day Jeffrey Warner Dennis Warner Marina Gritsenko Aliya Asghar Andrew Stolz Timothy Morgan Craig McClain Jon Jacobs Irina Kirpich Source Type: research

Molecular Signature of Antibody-Mediated Chronic Vasculopathy in Heart Allografts in a Novel Mouse Model
In conclusion, these findings report a novel model of antibody-mediated CAV that will facilitate further understanding of the molecular mechanisms promoting development of CAV.PMID:35490714 | DOI:10.1016/j.ajpath.2022.04.003 (Source: Am J Pathol)
Source: Am J Pathol - May 1, 2022 Category: Pathology Authors: Hidetoshi Tsuda Nina Dvorina Karen S Keslar Jessica Nevarez-Mejia Nicole M Valenzuela Elaine F Reed Robert L Fairchild William M Baldwin Source Type: research

Hepatic protein and phosphoprotein signatures of alcohol-associated cirrhosis and hepatitis
Am J Pathol. 2022 Apr 28:S0002-9440(22)00121-3. doi: 10.1016/j.ajpath.2022.04.004. Online ahead of print.ABSTRACTAlcohol-associated liver disease (ALD) is a global healthcare burden with alcohol-associated cirrhosis (AC) and hepatitis (AH) being two clinical manifestations with poor prognosis. The limited efficacy of standard care for AC and AH highlights a need for therapeutic targets and strategies. The current study aimed to address this need through the identification of hepatic proteome and phosphoproteome signatures of AC and AH. Proteomic and phosphoproteomic analyses were conducted on explant liver tissue (test coh...
Source: Am J Pathol - May 1, 2022 Category: Pathology Authors: Josiah Hardesty Le Day Jeffrey Warner Dennis Warner Marina Gritsenko Aliya Asghar Andrew Stolz Timothy Morgan Craig McClain Jon Jacobs Irina Kirpich Source Type: research

Molecular Signature of Antibody-Mediated Chronic Vasculopathy in Heart Allografts in a Novel Mouse Model
In conclusion, these findings report a novel model of antibody-mediated CAV that will facilitate further understanding of the molecular mechanisms promoting development of CAV.PMID:35490714 | DOI:10.1016/j.ajpath.2022.04.003 (Source: Am J Pathol)
Source: Am J Pathol - May 1, 2022 Category: Pathology Authors: Hidetoshi Tsuda Nina Dvorina Karen S Keslar Jessica Nevarez-Mejia Nicole M Valenzuela Elaine F Reed Robert L Fairchild William M Baldwin Source Type: research

Hepatic protein and phosphoprotein signatures of alcohol-associated cirrhosis and hepatitis
Am J Pathol. 2022 Apr 28:S0002-9440(22)00121-3. doi: 10.1016/j.ajpath.2022.04.004. Online ahead of print.ABSTRACTAlcohol-associated liver disease (ALD) is a global healthcare burden with alcohol-associated cirrhosis (AC) and hepatitis (AH) being two clinical manifestations with poor prognosis. The limited efficacy of standard care for AC and AH highlights a need for therapeutic targets and strategies. The current study aimed to address this need through the identification of hepatic proteome and phosphoproteome signatures of AC and AH. Proteomic and phosphoproteomic analyses were conducted on explant liver tissue (test coh...
Source: Am J Pathol - May 1, 2022 Category: Pathology Authors: Josiah Hardesty Le Day Jeffrey Warner Dennis Warner Marina Gritsenko Aliya Asghar Andrew Stolz Timothy Morgan Craig McClain Jon Jacobs Irina Kirpich Source Type: research

Molecular Signature of Antibody-Mediated Chronic Vasculopathy in Heart Allografts in a Novel Mouse Model
In conclusion, these findings report a novel model of antibody-mediated CAV that will facilitate further understanding of the molecular mechanisms promoting development of CAV.PMID:35490714 | DOI:10.1016/j.ajpath.2022.04.003 (Source: Am J Pathol)
Source: Am J Pathol - May 1, 2022 Category: Pathology Authors: Hidetoshi Tsuda Nina Dvorina Karen S Keslar Jessica Nevarez-Mejia Nicole M Valenzuela Elaine F Reed Robert L Fairchild William M Baldwin Source Type: research

Hepatic protein and phosphoprotein signatures of alcohol-associated cirrhosis and hepatitis
Am J Pathol. 2022 Apr 28:S0002-9440(22)00121-3. doi: 10.1016/j.ajpath.2022.04.004. Online ahead of print.ABSTRACTAlcohol-associated liver disease (ALD) is a global healthcare burden with alcohol-associated cirrhosis (AC) and hepatitis (AH) being two clinical manifestations with poor prognosis. The limited efficacy of standard care for AC and AH highlights a need for therapeutic targets and strategies. The current study aimed to address this need through the identification of hepatic proteome and phosphoproteome signatures of AC and AH. Proteomic and phosphoproteomic analyses were conducted on explant liver tissue (test coh...
Source: Am J Pathol - May 1, 2022 Category: Pathology Authors: Josiah Hardesty Le Day Jeffrey Warner Dennis Warner Marina Gritsenko Aliya Asghar Andrew Stolz Timothy Morgan Craig McClain Jon Jacobs Irina Kirpich Source Type: research

Molecular Signature of Antibody-Mediated Chronic Vasculopathy in Heart Allografts in a Novel Mouse Model
In conclusion, these findings report a novel model of antibody-mediated CAV that will facilitate further understanding of the molecular mechanisms promoting development of CAV.PMID:35490714 | DOI:10.1016/j.ajpath.2022.04.003 (Source: Am J Pathol)
Source: Am J Pathol - May 1, 2022 Category: Pathology Authors: Hidetoshi Tsuda Nina Dvorina Karen S Keslar Jessica Nevarez-Mejia Nicole M Valenzuela Elaine F Reed Robert L Fairchild William M Baldwin Source Type: research

Hepatic protein and phosphoprotein signatures of alcohol-associated cirrhosis and hepatitis
Am J Pathol. 2022 Apr 28:S0002-9440(22)00121-3. doi: 10.1016/j.ajpath.2022.04.004. Online ahead of print.ABSTRACTAlcohol-associated liver disease (ALD) is a global healthcare burden with alcohol-associated cirrhosis (AC) and hepatitis (AH) being two clinical manifestations with poor prognosis. The limited efficacy of standard care for AC and AH highlights a need for therapeutic targets and strategies. The current study aimed to address this need through the identification of hepatic proteome and phosphoproteome signatures of AC and AH. Proteomic and phosphoproteomic analyses were conducted on explant liver tissue (test coh...
Source: Am J Pathol - May 1, 2022 Category: Pathology Authors: Josiah Hardesty Le Day Jeffrey Warner Dennis Warner Marina Gritsenko Aliya Asghar Andrew Stolz Timothy Morgan Craig McClain Jon Jacobs Irina Kirpich Source Type: research