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Direct Visualization of Tracer Permeation into the Endolymph in Human Patients Using MR Imaging
CONCLUSION: This study provides the first in vivo systematic confirmation of GBCA entering the endolymph following intravenous administration. Notably, endolymph uptake peaked at 24h, significantly later than perilymph and CSF. The lack of a link between endolymph contrast and both perilymph and age suggests distinct uptake mechanisms. These findings shed light on inner ear fluid dynamics and their potential implications in Ménière's disease and other inner ear disorders.PMID:38569839 | DOI:10.2463/mrms.mp.2024-0011 (Source: Magnetic Resonance in Medical Sciences)
Source: Magnetic Resonance in Medical Sciences - April 3, 2024 Category: Radiology Authors: Shinji Naganawa Rintaro Ito Mariko Kawamura Toshiaki Taoka Tadao Yoshida Michihiko Sone Source Type: research

Diffusion Tensor Image Analysis ALong the Perivascular Space (DTI-ALPS): Revisiting the Meaning and Significance of the Method
Magn Reson Med Sci. 2024 Apr 2. doi: 10.2463/mrms.rev.2023-0175. Online ahead of print.ABSTRACTMore than 5 years have passed since the Diffusion Tensor Image Analysis ALong the Perivascular Space (DTI-ALPS) method was proposed with the intention of evaluating the glymphatic system. This method is handy due to its noninvasiveness, provision of a simple index in a straightforward formula, and the possibility of retrospective analysis. Therefore, the ALPS method was adopted to evaluate the glymphatic system for many disorders in many studies. The purpose of this review is to look back and discuss the ALPS method at this momen...
Source: Magnetic Resonance in Medical Sciences - April 3, 2024 Category: Radiology Authors: Toshiaki Taoka Rintaro Ito Rei Nakamichi Toshiki Nakane Hisashi Kawai Shinji Naganawa Source Type: research

Direct Visualization of Tracer Permeation into the Endolymph in Human Patients Using MR Imaging
CONCLUSION: This study provides the first in vivo systematic confirmation of GBCA entering the endolymph following intravenous administration. Notably, endolymph uptake peaked at 24h, significantly later than perilymph and CSF. The lack of a link between endolymph contrast and both perilymph and age suggests distinct uptake mechanisms. These findings shed light on inner ear fluid dynamics and their potential implications in Ménière's disease and other inner ear disorders.PMID:38569839 | DOI:10.2463/mrms.mp.2024-0011 (Source: Magnetic Resonance in Medical Sciences)
Source: Magnetic Resonance in Medical Sciences - April 3, 2024 Category: Radiology Authors: Shinji Naganawa Rintaro Ito Mariko Kawamura Toshiaki Taoka Tadao Yoshida Michihiko Sone Source Type: research

Diffusion Tensor Image Analysis ALong the Perivascular Space (DTI-ALPS): Revisiting the Meaning and Significance of the Method
Magn Reson Med Sci. 2024 Apr 2. doi: 10.2463/mrms.rev.2023-0175. Online ahead of print.ABSTRACTMore than 5 years have passed since the Diffusion Tensor Image Analysis ALong the Perivascular Space (DTI-ALPS) method was proposed with the intention of evaluating the glymphatic system. This method is handy due to its noninvasiveness, provision of a simple index in a straightforward formula, and the possibility of retrospective analysis. Therefore, the ALPS method was adopted to evaluate the glymphatic system for many disorders in many studies. The purpose of this review is to look back and discuss the ALPS method at this momen...
Source: Magnetic Resonance in Medical Sciences - April 3, 2024 Category: Radiology Authors: Toshiaki Taoka Rintaro Ito Rei Nakamichi Toshiki Nakane Hisashi Kawai Shinji Naganawa Source Type: research

Direct Visualization of Tracer Permeation into the Endolymph in Human Patients Using MR Imaging
CONCLUSION: This study provides the first in vivo systematic confirmation of GBCA entering the endolymph following intravenous administration. Notably, endolymph uptake peaked at 24h, significantly later than perilymph and CSF. The lack of a link between endolymph contrast and both perilymph and age suggests distinct uptake mechanisms. These findings shed light on inner ear fluid dynamics and their potential implications in Ménière's disease and other inner ear disorders.PMID:38569839 | DOI:10.2463/mrms.mp.2024-0011 (Source: Magnetic Resonance in Medical Sciences)
Source: Magnetic Resonance in Medical Sciences - April 3, 2024 Category: Radiology Authors: Shinji Naganawa Rintaro Ito Mariko Kawamura Toshiaki Taoka Tadao Yoshida Michihiko Sone Source Type: research

Diffusion Tensor Image Analysis ALong the Perivascular Space (DTI-ALPS): Revisiting the Meaning and Significance of the Method
Magn Reson Med Sci. 2024 Apr 2. doi: 10.2463/mrms.rev.2023-0175. Online ahead of print.ABSTRACTMore than 5 years have passed since the Diffusion Tensor Image Analysis ALong the Perivascular Space (DTI-ALPS) method was proposed with the intention of evaluating the glymphatic system. This method is handy due to its noninvasiveness, provision of a simple index in a straightforward formula, and the possibility of retrospective analysis. Therefore, the ALPS method was adopted to evaluate the glymphatic system for many disorders in many studies. The purpose of this review is to look back and discuss the ALPS method at this momen...
Source: Magnetic Resonance in Medical Sciences - April 3, 2024 Category: Radiology Authors: Toshiaki Taoka Rintaro Ito Rei Nakamichi Toshiki Nakane Hisashi Kawai Shinji Naganawa Source Type: research

Direct Visualization of Tracer Permeation into the Endolymph in Human Patients Using MR Imaging
CONCLUSION: This study provides the first in vivo systematic confirmation of GBCA entering the endolymph following intravenous administration. Notably, endolymph uptake peaked at 24h, significantly later than perilymph and CSF. The lack of a link between endolymph contrast and both perilymph and age suggests distinct uptake mechanisms. These findings shed light on inner ear fluid dynamics and their potential implications in Ménière's disease and other inner ear disorders.PMID:38569839 | DOI:10.2463/mrms.mp.2024-0011 (Source: Magnetic Resonance in Medical Sciences)
Source: Magnetic Resonance in Medical Sciences - April 3, 2024 Category: Radiology Authors: Shinji Naganawa Rintaro Ito Mariko Kawamura Toshiaki Taoka Tadao Yoshida Michihiko Sone Source Type: research

Diffusion Tensor Image Analysis ALong the Perivascular Space (DTI-ALPS): Revisiting the Meaning and Significance of the Method
Magn Reson Med Sci. 2024 Apr 2. doi: 10.2463/mrms.rev.2023-0175. Online ahead of print.ABSTRACTMore than 5 years have passed since the Diffusion Tensor Image Analysis ALong the Perivascular Space (DTI-ALPS) method was proposed with the intention of evaluating the glymphatic system. This method is handy due to its noninvasiveness, provision of a simple index in a straightforward formula, and the possibility of retrospective analysis. Therefore, the ALPS method was adopted to evaluate the glymphatic system for many disorders in many studies. The purpose of this review is to look back and discuss the ALPS method at this momen...
Source: Magnetic Resonance in Medical Sciences - April 3, 2024 Category: Radiology Authors: Toshiaki Taoka Rintaro Ito Rei Nakamichi Toshiki Nakane Hisashi Kawai Shinji Naganawa Source Type: research

Direct Visualization of Tracer Permeation into the Endolymph in Human Patients Using MR Imaging
CONCLUSION: This study provides the first in vivo systematic confirmation of GBCA entering the endolymph following intravenous administration. Notably, endolymph uptake peaked at 24h, significantly later than perilymph and CSF. The lack of a link between endolymph contrast and both perilymph and age suggests distinct uptake mechanisms. These findings shed light on inner ear fluid dynamics and their potential implications in Ménière's disease and other inner ear disorders.PMID:38569839 | DOI:10.2463/mrms.mp.2024-0011 (Source: Magnetic Resonance in Medical Sciences)
Source: Magnetic Resonance in Medical Sciences - April 3, 2024 Category: Radiology Authors: Shinji Naganawa Rintaro Ito Mariko Kawamura Toshiaki Taoka Tadao Yoshida Michihiko Sone Source Type: research

Diffusion Tensor Image Analysis ALong the Perivascular Space (DTI-ALPS): Revisiting the Meaning and Significance of the Method
Magn Reson Med Sci. 2024 Apr 2. doi: 10.2463/mrms.rev.2023-0175. Online ahead of print.ABSTRACTMore than 5 years have passed since the Diffusion Tensor Image Analysis ALong the Perivascular Space (DTI-ALPS) method was proposed with the intention of evaluating the glymphatic system. This method is handy due to its noninvasiveness, provision of a simple index in a straightforward formula, and the possibility of retrospective analysis. Therefore, the ALPS method was adopted to evaluate the glymphatic system for many disorders in many studies. The purpose of this review is to look back and discuss the ALPS method at this momen...
Source: Magnetic Resonance in Medical Sciences - April 3, 2024 Category: Radiology Authors: Toshiaki Taoka Rintaro Ito Rei Nakamichi Toshiki Nakane Hisashi Kawai Shinji Naganawa Source Type: research

Direct Visualization of Tracer Permeation into the Endolymph in Human Patients Using MR Imaging
CONCLUSION: This study provides the first in vivo systematic confirmation of GBCA entering the endolymph following intravenous administration. Notably, endolymph uptake peaked at 24h, significantly later than perilymph and CSF. The lack of a link between endolymph contrast and both perilymph and age suggests distinct uptake mechanisms. These findings shed light on inner ear fluid dynamics and their potential implications in Ménière's disease and other inner ear disorders.PMID:38569839 | DOI:10.2463/mrms.mp.2024-0011 (Source: Magnetic Resonance in Medical Sciences)
Source: Magnetic Resonance in Medical Sciences - April 3, 2024 Category: Radiology Authors: Shinji Naganawa Rintaro Ito Mariko Kawamura Toshiaki Taoka Tadao Yoshida Michihiko Sone Source Type: research

Diffusion Tensor Image Analysis ALong the Perivascular Space (DTI-ALPS): Revisiting the Meaning and Significance of the Method
Magn Reson Med Sci. 2024 Apr 2. doi: 10.2463/mrms.rev.2023-0175. Online ahead of print.ABSTRACTMore than 5 years have passed since the Diffusion Tensor Image Analysis ALong the Perivascular Space (DTI-ALPS) method was proposed with the intention of evaluating the glymphatic system. This method is handy due to its noninvasiveness, provision of a simple index in a straightforward formula, and the possibility of retrospective analysis. Therefore, the ALPS method was adopted to evaluate the glymphatic system for many disorders in many studies. The purpose of this review is to look back and discuss the ALPS method at this momen...
Source: Magnetic Resonance in Medical Sciences - April 3, 2024 Category: Radiology Authors: Toshiaki Taoka Rintaro Ito Rei Nakamichi Toshiki Nakane Hisashi Kawai Shinji Naganawa Source Type: research

Direct Visualization of Tracer Permeation into the Endolymph in Human Patients Using MR Imaging
CONCLUSION: This study provides the first in vivo systematic confirmation of GBCA entering the endolymph following intravenous administration. Notably, endolymph uptake peaked at 24h, significantly later than perilymph and CSF. The lack of a link between endolymph contrast and both perilymph and age suggests distinct uptake mechanisms. These findings shed light on inner ear fluid dynamics and their potential implications in Ménière's disease and other inner ear disorders.PMID:38569839 | DOI:10.2463/mrms.mp.2024-0011 (Source: Magnetic Resonance in Medical Sciences)
Source: Magnetic Resonance in Medical Sciences - April 3, 2024 Category: Radiology Authors: Shinji Naganawa Rintaro Ito Mariko Kawamura Toshiaki Taoka Tadao Yoshida Michihiko Sone Source Type: research

Diffusion Tensor Image Analysis ALong the Perivascular Space (DTI-ALPS): Revisiting the Meaning and Significance of the Method
Magn Reson Med Sci. 2024 Apr 2. doi: 10.2463/mrms.rev.2023-0175. Online ahead of print.ABSTRACTMore than 5 years have passed since the Diffusion Tensor Image Analysis ALong the Perivascular Space (DTI-ALPS) method was proposed with the intention of evaluating the glymphatic system. This method is handy due to its noninvasiveness, provision of a simple index in a straightforward formula, and the possibility of retrospective analysis. Therefore, the ALPS method was adopted to evaluate the glymphatic system for many disorders in many studies. The purpose of this review is to look back and discuss the ALPS method at this momen...
Source: Magnetic Resonance in Medical Sciences - April 3, 2024 Category: Radiology Authors: Toshiaki Taoka Rintaro Ito Rei Nakamichi Toshiki Nakane Hisashi Kawai Shinji Naganawa Source Type: research

Direct Visualization of Tracer Permeation into the Endolymph in Human Patients Using MR Imaging
CONCLUSION: This study provides the first in vivo systematic confirmation of GBCA entering the endolymph following intravenous administration. Notably, endolymph uptake peaked at 24h, significantly later than perilymph and CSF. The lack of a link between endolymph contrast and both perilymph and age suggests distinct uptake mechanisms. These findings shed light on inner ear fluid dynamics and their potential implications in Ménière's disease and other inner ear disorders.PMID:38569839 | DOI:10.2463/mrms.mp.2024-0011 (Source: Magnetic Resonance in Medical Sciences)
Source: Magnetic Resonance in Medical Sciences - April 3, 2024 Category: Radiology Authors: Shinji Naganawa Rintaro Ito Mariko Kawamura Toshiaki Taoka Tadao Yoshida Michihiko Sone Source Type: research