Current Paradigms in COVID-19 Research: Proposed Treatment Strategies, Recent Trends and Future Directions.
CONCLUSIONS: It is anticipated that this review would certainly assist the public in general and scientific community in particular to recognize and effectively deal with COVID-19, providing a reference guide for futuristic studies. PMID: 32651959 [PubMed - as supplied by publisher] (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - July 11, 2020 Category: Chemistry Authors: Sharma AK, Sharma V, Sharma A, Pallikkuth S Tags: Curr Med Chem Source Type: research

Transcriptional dysregulation in Huntington's Disease. The role in pathogenesis and potency for pharmacological targeting.
Abstract Huntington's disease (HD) is an inherited neurodegenerative disorder caused by a mutation in the gene that encodes a critical cell regulatory protein, huntingtin (Htt). The expansion of cytosine-adenine-guanine (CAG) trinucleotide repeats causes improper folding of functional proteins and is an initial trigger of pathological changes in the brain. Recent research has indicated that the functional dysregulation of many transcription factors underlies the neurodegenerative processes that accompany HD. These disturbances are caused not only by the loss of wild-type Htt (WT Htt) function but also by the occur...
Source: Current Medicinal Chemistry - July 5, 2020 Category: Chemistry Authors: Pogoda A, Chmielewska N, Maciejak P, Szyndler J Tags: Curr Med Chem Source Type: research

NMR spectroscopy in the conformational analysis of peptides: an overview.
CONCLUSION: NMR is a leading technique in the study of conformational preferences of small flexible peptides whose structure can be often only described by an ensemble of conformations. Although NMR studies of peptides can be easily and fast performed by canonical protocols established a few decades ago, more recently we have assisted to tremendous improvements of NMR spectroscopy to investigate instead large systems and overcome its molecular weight limit. PMID: 32614739 [PubMed - as supplied by publisher] (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - July 2, 2020 Category: Chemistry Authors: Vincenzi M, Mercurio FA, Leone M Tags: Curr Med Chem Source Type: research

The chronicle of COVID-19: possible strategies to curb the pandemic.
Abstract COVID-19, an epidemic that emerged in Wuhan, has become a pandemic affecting worldwide and is in a rapidly evolving condition. Day by day, the confirmed cases and deaths are increasing many folds. SARS-CoV-2 is a novel virus; therefore, limited data are available to curb the disease. Epidemiological approaches, isolation, quarantine, social distancing, lockdown, and curfew are being employed to halt the spread of the disease. Individual and joint efforts all over the world are producing a wealth of data and information which are expected to produce therapeutic strategies against COVID-19. Current research...
Source: Current Medicinal Chemistry - July 2, 2020 Category: Chemistry Authors: Kumar R, Harilal S, Al-Sehemi AG, Mathew GE, Carradori S, Mathew B Tags: Curr Med Chem Source Type: research

Negative air ions in neuropsychiatric disorders.
CONCLUSION: A growing evidence of data, although not yet conclusive, would suggest that NAIs might improve cognitive processes. These findings require specific and urgent controlled trials adopting systems based on AIs release to possible prevent and treat cognitive dysfunctions present in a broad range of neuropsychiatric conditions. PMID: 32603272 [PubMed - as supplied by publisher] (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - June 29, 2020 Category: Chemistry Authors: Della Vecchia A, Mucci F, Pozza A, Marazziti D Tags: Curr Med Chem Source Type: research

Advances In Drug Therapy For Systemic Lupus Erythematosus.
CONCLUSION: This article summarizes the pathogenesis of systemic lupus erythematosus, and summarizes the traditional and new therapeutic drugs, which is not only beneficial to the treatment of lupus erythematosus patients, but also plays a vital reference significance for the future development of new systemic lupus erythematosus drugs. PMID: 32586244 [PubMed - as supplied by publisher] (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - June 25, 2020 Category: Chemistry Authors: Zhao X, Zhang J, Liang Y, Li J, Ding S, Wang Y, Chen Y, Liu J Tags: Curr Med Chem Source Type: research

Tumor in 3D: in vitro complex cellular models to improve nanodrugs cancer therapy.
Abstract Nanodrugs represent novel solutions to reshuffle repurposed drugs for cancer therapy. They might offer different therapeutic options by combining targeted drug delivery and imaging in unique platforms. Such nanomaterials are deemed to overcome the limitations of currently available treatments, ultimately improving patients' life quality. However, despite these promises being made for over three decades, the poor clinical translation of nanoparticle-based therapies calls for deeper in vitro and in vivo investigations. Translational issues arise very early during the development of nanodrugs, where complex ...
Source: Current Medicinal Chemistry - June 25, 2020 Category: Chemistry Authors: Fernandes S, Cassani M, Pagliari S, Filipensky P, Cavalieri F, Forte G Tags: Curr Med Chem Source Type: research

Cholecystokinin-2 receptor targeting with radiolabeled peptides: current status and future directions.
EV Abstract A wide variety of radiolabeled peptide analogs for specific targeting of cholecystokinin-2 receptors has been developed in the last decades. Peptide probes based on the natural ligands minigastrin (MG) and cholecystokinin (CCK) have high potential for molecular imaging and targeted radiotherapy of different human tumors, such as medullary thyroid carcinoma (MTC) and small cell lung cancer (SCLC). MG analogs with high persistent uptake in CCK2R expressing tumors have been preferably used for the development of radiolabeled peptide analogs. The clinical translation of CCK2R targeting has been prevented ...
Source: Current Medicinal Chemistry - June 25, 2020 Category: Chemistry Authors: Klingler M, Hörmann AA, Guggenberg EV Tags: Curr Med Chem Source Type: research

Recent Advances in Bio-medicinal and Pharmaceutical Applications of Bio-based Materials.
PMID: 32571198 [PubMed - as supplied by publisher] (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - June 21, 2020 Category: Chemistry Authors: Si C, Xu J Tags: Curr Med Chem Source Type: research

Commentary on "Antimicrobial Capacity of Plant Polyphenols against Gram-positive Bacteria: A Comprehensive Review" authored by Enrique Barraj ón-Catalán, Institute of Molecular and Cell Biology (IBMC), Miguel Hernandez University (UMH), Avda. Universidad s/n, Elche 03202. Spain.
Commentary on "Antimicrobial Capacity of Plant Polyphenols against Gram-positive Bacteria: A Comprehensive Review" authored by Enrique Barrajón-Catalán, Institute of Molecular and Cell Biology (IBMC), Miguel Hernandez University (UMH), Avda. Universidad s/n, Elche 03202. Spain. Curr Med Chem. 2020 Jun 21;: Authors: Abraham WR PMID: 32571199 [PubMed - as supplied by publisher] (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - June 21, 2020 Category: Chemistry Authors: Abraham WR Tags: Curr Med Chem Source Type: research

Commentary on "Non-Steroidal Anti-inflammatory Drugs Loaded Liposomes for Topical Treatment of Inflammatory and Degenerative Conditions" by Carla Matos, FP-ENAS- UFP Energy, Environment and Health Research Unit/CEBIMED-Centro de Estudos em Biomedicina, Fernando Pessoa University, Porto, Portugal. Challenges and Prospects of Topical Treatment of Inflammatory and Degenerative Conditions: A Vesicular Approach.
Commentary on "Non-Steroidal Anti-inflammatory Drugs Loaded Liposomes for Topical Treatment of Inflammatory and Degenerative Conditions" by Carla Matos, FP-ENAS- UFP Energy, Environment and Health Research Unit/CEBIMED-Centro de Estudos em Biomedicina, Fernando Pessoa University, Porto, Portugal. Challenges and Prospects of Topical Treatment of Inflammatory and Degenerative Conditions: A Vesicular Approach. Curr Med Chem. 2020 Jun 19;: Authors: Nasr M PMID: 32571195 [PubMed - as supplied by publisher] (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - June 19, 2020 Category: Chemistry Authors: Nasr M Tags: Curr Med Chem Source Type: research

Innovative Therapeutic Strategies in the Molecular Targeting Era.
PMID: 32571196 [PubMed - as supplied by publisher] (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - June 19, 2020 Category: Chemistry Authors: Nishimura JI Tags: Curr Med Chem Source Type: research

Cardiovascular Disease: From Diagnosis to Therapy.
PMID: 32571197 [PubMed - as supplied by publisher] (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - June 19, 2020 Category: Chemistry Authors: Papageorgiou N Tags: Curr Med Chem Source Type: research

Ghrelin Based Therapy of Metabolic Diseases.
CONCLUSION: Various compounds targeting the ghrelin-GHSR system have shown promising efficacy for intervention of obesity and relevant metabolic disorders in animals and in vitro. Further clinical trials to validate their efficacy in human being are urgently needed. PMID: 32538716 [PubMed - as supplied by publisher] (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - June 15, 2020 Category: Chemistry Authors: Liang Y, Yin W, Yin Y, Zhang W Tags: Curr Med Chem Source Type: research

Radiolabeled peptides for molecular imaging of apoptosis.
Abstract Apoptosis is a regulated cell death induced by extrinsic and intrinsic stimulants. Tracking of apoptosis provides an opportunity for assessment of cardiovascular and neurodegenerative diseases and also monitoring of cancer therapy at early stages. There are some key mediators in apoptosis cascade which could be considered as specific targets for delivering imaging or therapeutic agents. The targeted radioisotope-based imaging agents are able to sensitively detect the physiological signal pathways which make them suitable for apoptosis imaging at a single-cell level. Radiopeptides take advantage of both th...
Source: Current Medicinal Chemistry - June 12, 2020 Category: Chemistry Authors: Mosayebnia M, Hajiramezanali M, Shahhosseini S Tags: Curr Med Chem Source Type: research

Commentary on "Peptide-Conjugated Nanoparticles as Targeted Anti-angiogenesis Therapeutic and Diagnostic in Cancer" by Shaker A. Mousa, Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY 12144, United States - Peptide-Conjugated Nanoparticles for Multimodal Nanomedicine.
Commentary on "Peptide-Conjugated Nanoparticles as Targeted Anti-angiogenesis Therapeutic and Diagnostic in Cancer" by Shaker A. Mousa, Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY 12144, United States - Peptide-Conjugated Nanoparticles for Multimodal Nanomedicine. Curr Med Chem. 2020;27(17):2927-2928 Authors: Singh AV PMID: 32515306 [PubMed - in process] (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - June 11, 2020 Category: Chemistry Authors: Singh AV Tags: Curr Med Chem Source Type: research

Hydrogels based on Natural Polymers for Medicinal Applications.
PMID: 32515308 [PubMed - in process] (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - June 11, 2020 Category: Chemistry Authors: Chen Y Tags: Curr Med Chem Source Type: research

Chemo-drug controlled-release strategies of nanocarrier in the development of cancer therapeutics.
Abstract Nanoparticles have been widely used in cancer therapy because of its nanoscale, high surface ratio, multifuntions and so on. With specific construction of nanoparticles, such as choosing magnetic nanomaterials or citric acid coated nanoparticle, scientists can kill tumor cells effectively and accurately,importantly, reducing the side effect of conventional chemotherapy. Currently, they have been continually applied in cancer therapeutics research. Scientists not only designed nanoparticles loading with therapeutic drugs, but also equipped with targeted molecules. These works make nanoparticles become ...
Source: Current Medicinal Chemistry - June 5, 2020 Category: Chemistry Authors: Liu Y, Ou H, Pei X, Jiang B, Ma Y, Liu N, Wen C, Peng C, Hu X Tags: Curr Med Chem Source Type: research

Advancing the Therapeutic Efficacy of Bioactive Molecules by Delivery Vehicle Platforms.
Abstract Drugs have to overcome numerous barriers to reach their desired therapeutic targets. In several cases drugs, especially the highly lipophilic molecules, suffer from low solubility and bioavailability and therefore their desired targeting is hampered. In addition, undesired metabolic products might be produced or off-targets could be recognized. Along these lines, nanopharmacology has provided new technological platforms, to overcome these boundaries. Specifically, numerous vehicle platforms such as cyclodextrins and calixarenes have been widely utilized to host lipophilic drugs such as antagonists of the ...
Source: Current Medicinal Chemistry - June 5, 2020 Category: Chemistry Authors: Tsiailanis AD, Tzakos AG, Mavromoustakos T Tags: Curr Med Chem Source Type: research

Oxidative and nitrosative stress involvement in the pathogenesis of obstructive lung diseases of increasing severity.
Abstract The imbalance between increased oxidative agents and antioxidant defence mechanisms is central in the pathogenesis of obstructive lung diseases such as asthma and COPD. In these patients, there are increased levels of reactive oxygen species. Superoxide anions (O2 - ), hydrogen peroxide (H2O2) and hydroxyl radicals (.OH) are critical for the formation of further cytotoxic radicals in the bronchi and lung parenchyma. Chronic inflammation, partly induced by oxidative stress, can further increase the oxidant burden through activated phagocytic cells (neutrophils, eosinophils, macrophages), particularly in se...
Source: Current Medicinal Chemistry - June 4, 2020 Category: Chemistry Authors: Di Stefano A, Maniscalco M, Balbi B, Ricciardolo FLM Tags: Curr Med Chem Source Type: research

Current film coating designs for colon-targeted oral delivery.
Abstract Colon-targeted oral delivery has recently attracted a substantial number of studies on both systemic and local treatments. Among approaches for colonic delivery, film coatings have been demonstrated as effective elements of the drug delivery systems because they can integrate multiple release strategies, such as pH-controlled release, time-controlled release and enzyme-triggered release. Moreover, coating layer modulations, natural film materials and nanoparticle coatings have been vigorously investigated with promising applications. This review aims to describe the primary approaches for improving drug d...
Source: Current Medicinal Chemistry - June 4, 2020 Category: Chemistry Authors: Tran PHL, Tran TTD Tags: Curr Med Chem Source Type: research

"New perspectives in the pharmacological potential of naringin in medicine".
CONCLUSION: NAR is endowed with broad biological effects that could improve human health. Since a scarce number of clinical studies have been performed, the use of them requires more investigation in order to know better their safety, efficacy, delivery and bioavailability in humans. PMID: 32496985 [PubMed - as supplied by publisher] (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - June 4, 2020 Category: Chemistry Authors: Rivoira MA, Rodriguez V, Talamoni G, de Talamoni NT Tags: Curr Med Chem Source Type: research

Clinical Values of Nitric Oxide Parameters from the Respiratory System.
CONCLUSION: NO parameters may be useful for diagnosis, prediction of disease progression and prediction of treatment responses in different parenchymal lung and airway diseases. Formal trials to test the added clinical value of NO parameters are needed. PMID: 32493184 [PubMed - as supplied by publisher] (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - June 3, 2020 Category: Chemistry Authors: Lehtimäki L, Karvonen T, Högman M Tags: Curr Med Chem Source Type: research

Natural product inhibitors of cyclooxygenase (COX) enzyme: A Review on Current status and future perspectives.
CONCLUSION: COX inhibitors served as a potential source of lead molecules for discovery and development of anti-inflammatory drugs. Compilation of natural product and semi-synthetic inhibitors of COX may serve as valuable information to the researchers who are looking for possible lead molecules from natural source to conduct further preclinical and clinical studies. PMID: 32484764 [PubMed - as supplied by publisher] (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - June 2, 2020 Category: Chemistry Authors: Ambati G G, Jachak SM Tags: Curr Med Chem Source Type: research

Antitumor effects of triterpenes in hepatocellular carcinoma.
CONCLUSION: Triterpenes could become a future strategy to address HCC or at least improve results when administered in combination with chemotherapeutic agents. PMID: 32484765 [PubMed - as supplied by publisher] (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - June 2, 2020 Category: Chemistry Authors: Sureda A, Martorell M, Capó X, Monserrat-Mesquida M, Quetglas-Llabrés MM, Rasekhian M, Nabavi SM, Tejada S Tags: Curr Med Chem Source Type: research

Recent Advances in Peptide Nucleic Acids as Antibacterial Agents.
Abstract The emergence of antibiotic-resistant bacteria and the slow progress in searching for new antimicrobial agents make it hard to treat bacterial infections and cause problems for the healthcare system worldwide, including high costs, prolonged hospitalizations, and increased mortality. Therefore, the discovery of effective antibacterial agents is of great importance. One attractive alternative is antisense peptide nucleic acid (PNA), which inhibits or eliminates gene expression by binding to the complementary messenger RNA (mRNA) sequence of essential genes or the accessible and functionally important regio...
Source: Current Medicinal Chemistry - June 2, 2020 Category: Chemistry Authors: Chen W, Dong B, Liu W, Liu Z Tags: Curr Med Chem Source Type: research

Convolutional Neural Network Based Virtual Screening.
Abstract Virtual screening is an important means for lead compound discovery. The scoring function is the key to selecting hit compounds. Many scoring functions are currently available; however, there are no all-purpose scoring functions because different scoring functions tend to have conflicting results. Recently, neural networks, especially convolutional neural networks, have been constantly penetrating drug design and most CNN-based virtual screening methods are superior to traditional docking methods, such as Dock and AutoDock. CNN-based virtual screening is expected to improve the previous model of overrelia...
Source: Current Medicinal Chemistry - May 26, 2020 Category: Chemistry Authors: Shan W, Li X, Yao H, Lin K Tags: Curr Med Chem Source Type: research

The Effect of Oxidative Stress and Antioxidant Therapies on Pancreatic B-cell Dysfunction: Results from in Vitro and in Vivo Studies.
CONCLUSION: Antioxidants hold promise for developing strategies aimed at the prevention or treatment of diabetes mellitus associated with pancreatic β-cells dysfunction, as supported by in vitro and in vivo studies. However, more in vitro studies are required about drugs. PMID: 32452321 [PubMed - as supplied by publisher] (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - May 26, 2020 Category: Chemistry Authors: Anastasiou IA, Eleftheriadou I, Tentolouris A, Koliaki C, Kosta OA, Tentolouris N Tags: Curr Med Chem Source Type: research

The effect of chalcones on the main sources of reactive species production: possible therapeutic implications in diabetes mellitus.
Abstract Diabetes mellitus (DM) is characterized by hyperglycemia, resulting from defects in insulin secretion, insulin action or both. There are several factors such as hyperlipidemia and oxidative stress (OS), namely the production of reactive oxygen/nitrogen species (ROS/RNS), that actively contribute to the development and worsening of DM. Chalcones, also termed as benzalacetophenone or benzylidene acetophenone, present a 1,3-diaryl-2-propen-1-one scaffold that has been shown to be highly promising in the development of new antioxidant compounds. Considering the potential interest of antioxidant therapy, the p...
Source: Current Medicinal Chemistry - May 24, 2020 Category: Chemistry Authors: Sousa A, Ribeiro D, Fernandes E, Freitas M Tags: Curr Med Chem Source Type: research

The nitric oxide pathway in pulmonary arterial hypertension: pathomechanism, biomarkers and drug targets.
záros M, Bikov A Abstract The altered nitric oxide (NO) pathway in the pulmonary endothelium leads to increased vascular smooth muscle tone and vascular remodelling, and thus contributes to the development and progression of pulmonary arterial hypertension (PAH). The pulmonary NO signalling is abrogated by the decreased expression and dysfunction of the endothelial NO synthase (eNOS) and the accumulation of factors blocking eNOS functionality. The NO deficiency of the pulmonary vasculature can be assessed by detecting nitric oxide in the exhaled breath or measuring the degradation products of NO (nitrite, n...
Source: Current Medicinal Chemistry - May 22, 2020 Category: Chemistry Authors: Lázár Z, Mészáros M, Bikov A Tags: Curr Med Chem Source Type: research

Tanshinones: An update in the medicinal chemistry in recent 5 years.
This article present a review of the anti-atherosclerotic effects, cardioprotective effects, anticancer activities, antibacterial activities and antiviral activities of tanshinones and structural modification work in recent years. PMID: 32436817 [PubMed - as supplied by publisher] (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - May 21, 2020 Category: Chemistry Authors: Lai Z, He J, Zhou C, Zhao H, Cui S Tags: Curr Med Chem Source Type: research

Curcumin: a dietary phytochemical for targeting the phenotype and function of dendritic cells.
Abstract Dendritic cells (DCs) are the most powerful antigen-presenting cells which link the innate and adaptive immune responses. Depending on the context DCs initiate the immune responses or contribute to immune tolerance. Any disturbance in their phenotypes and functions may initiate inflammatory or autoimmune diseases. Hence, dysregulated DCs are the most attractive pharmacological target for the development of new therapies aiming at reducing their immunogenicity and at enhancing their tolerogenicity. Curcumin is the polyphenolic phytochemical component of the spice turmeric with a wide range of pharmacologic...
Source: Current Medicinal Chemistry - May 14, 2020 Category: Chemistry Authors: Rahimi K, Hassanzadeh K, Khanbabaei H, Haftcheshmeh SM, Ahmadi A, Izadpanah E, Mohammadi A, Sahebkar A Tags: Curr Med Chem Source Type: research

Machine Learning-Based Scoring Functions. Development and Applications with SAnDReS.
CONCLUSION: Here, we reviewed the development of machine learning scoring functions to predict binding affinity through the application of the program SAnDReS. Our studies show the superior predictive performance of the SAnDReS-developed models when compared with classical scoring functions available in the programs such as AutoDock4, Molegro Virtual Docker, and AutoDock Vina. PMID: 32410551 [PubMed - as supplied by publisher] (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - May 14, 2020 Category: Chemistry Authors: Bitencourt-Ferreira G, Rizzotto C, de Azevedo Junior WF Tags: Curr Med Chem Source Type: research

Antiangiogenic Agents: A Review on Vascular Endothelial Growth Factor Receptor-2 (VEGFR-2) Inhibitors.
Abstract Tumor growth inhibition can be achieved by inhibiting angiogenesis, which has been a field of great concern in recent years. Important targets to inhibit angiogenesis include vascular endothelial growth factor receptor (VEGFR) and its homologous tyrosine kinase receptor. Anti-angiogenic therapy based on inhibition of VEGFR-2 is an effective clinical treatment strategy. The research progress of VEGFR-2 inhibitors is reviewed in this paper from the aspects of the drug development and chemical synthesis. PMID: 32407259 [PubMed - as supplied by publisher] (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - May 13, 2020 Category: Chemistry Authors: Cheng K, Liu CF, Rao GW Tags: Curr Med Chem Source Type: research

In vitro data of current therapies for SARS-CoV-2.
CONCLUSION: Scientist all over the world should work together and increase their efforts in order to find feasible and efficient solutions against this new global viral threat. PMID: 32400323 [PubMed - as supplied by publisher] (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - May 12, 2020 Category: Chemistry Authors: Anastasiou IA, Eleftheriadou I, Tentolouris A, Tsilingiris D, Tentolouris N Tags: Curr Med Chem Source Type: research

Highlights Regarding The Use Of Metallic Nanoparticles Against Pathogens Considered A Priority By The World Health Organization.
lli M Abstract The indiscriminate use of antibiotics has facilitated the growing resistance of bacteria, and this has become a serious public health problem worldwide. Several microorganisms are still resistant to multiple antibiotics, and are particularly dangerous in the hospital and nursing home environment, and to patients whose care requires devices such as ventilators and intravenous catheters. A list of twelve pathogenic genera, which especially included bacteria that were not affected by different antibiotics, was released by the World Health Organization (WHO) in 2017, and the research and development of ...
Source: Current Medicinal Chemistry - May 12, 2020 Category: Chemistry Authors: da Silva PB, Araújo VHS, Fonseca-Santos B, Solcia MC, Ribeiro CM, da Silva IC, Alves RC, Pironi AM, Silva ACL, Victorelli FD, Fernandes MA, Ferreira PS, da Silva GH, Pavan FR, Chorilli M Tags: Curr Med Chem Source Type: research

Biotechnological Potential of Streptomyces Siderophores as New Antibiotics.
CONCLUSION: This review confirms the importance of Streptomyces as a rich source of siderophores, and underlines their potential as antibacterial agents. PMID: 32389112 [PubMed - as supplied by publisher] (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - May 10, 2020 Category: Chemistry Authors: Terra L, Dyson P, Ratcliffe N, Castro HC, Vicente ACP Tags: Curr Med Chem Source Type: research

Chemistry and Pharmacology of Modulators of Oxidative Stress.
PMID: 32368965 [PubMed - as supplied by publisher] (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - May 6, 2020 Category: Chemistry Authors: Saso L, Suzen S, Borges F, Csont T Tags: Curr Med Chem Source Type: research

Anti-Atherosclerotic Effects of Spice-Derived Phytochemicals.
Abstract Cardiovascular diseases are the leading cause of death in the world. Atherosclerosis is characterized by oxidized lipid deposition, and inflammation in the arterial wall and represents a significant problem in public health and medicine. Some dietary spices have been widely used in many countries; however, the mechanism of their action as it relates to the prevention and treatment of atherosclerosis is still poorly understood. In this review, we focus on the properties of various spice-derived active ingredients used in the prevention and treatment of atherosclerosis, as well as associated atherosclerotic...
Source: Current Medicinal Chemistry - May 4, 2020 Category: Chemistry Authors: Enayati A, Johnston TP, Sahebkar A Tags: Curr Med Chem Source Type: research

Recent Advances in Asialoglycoprotein Receptor and Glycyrrhetinic Acid Receptor-Mediated and/or pH Responsive Hepatocellular Carcinoma-Targeted Drug Delivery.
CONCLUSION: The multifunctional DDS may prolong systemic circulation, continuously release drugs, increase drugs tumor accumulation at targeted site,enhance anticancer effect, and reduce side effects both in vitro or vivo. But it is rarely used to investigate MDR of HCC, it is need to further study before in clinical. PMID: 32368967 [PubMed - as supplied by publisher] (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - May 4, 2020 Category: Chemistry Authors: Li YL, Zhu XM, Liang H, Orvig C, Chen ZF Tags: Curr Med Chem Source Type: research

The roles of dietary, nutritional, and lifestyle interventions in adipose tissue adaptation and obesity.
ova O Abstract The obesity and the associated non-communicable diseases (NCDs) were globally increasing in their prevalence. While the modern-day lifestyle required less ventilation of metabolic energy through muscular activities, this lifestyle transition also provided the unlimited accession to foods around the clock, which prolonged the daily eating period of foods that contained high calorie and high glycemic load. These situations promoted the high continuous flux of carbon substrate availability in mitochondria and induced the indecisive bioenergetic switches. The disrupted bioenergetic milieu increased the ...
Source: Current Medicinal Chemistry - May 4, 2020 Category: Chemistry Authors: Bjørklund G, Tippairote T, Dadar M, Lizcano F, Aaseth J, Borisova O Tags: Curr Med Chem Source Type: research

Three Musketeers for Lowering Cholesterol: Statins, Ezetimibe and Evolocumab.
Abstract Coronary heart disease (CHD) is closely related to hypercholesterolemia, and lowering serum cholesterol is currently the most important strategy in reducing CHD. In humans, the serum cholesterol level is determined mainly by three metabolic pathways, namely, dietary cholesterol intake, cholesterol synthesis, and cholesterol degradation in vivo. An intervention that targets the key molecules in the three pathways is an important strategy in lowering serum lipids. Statins inhibit 3-hydroxyl-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase) to reduce lowdensity lipoprotein (LDL) by about 20% to 45%. ...
Source: Current Medicinal Chemistry - May 4, 2020 Category: Chemistry Authors: Xu Q, Deng Y, Xiao J, Liu X, Zhou M, Ren Z, Peng J, Tang Y, Jiang Z, Tang Z, Liu L Tags: Curr Med Chem Source Type: research

Cytotoxicity and Anti-cancer Activity of the Genus Achillea L.
CONCLUSION: The genus Achillea L. is a valuable source of bioactive secondary metabolites. The most significant outcome of the investigation of medicinal plants is the documentation and the assessment of the traditional information and its use and perspectives in the light of modern pharmacology. PMID: 32368970 [PubMed - as supplied by publisher] (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - May 4, 2020 Category: Chemistry Authors: Papakosta K, Grafakou ME, Barda C, Kostopoulos IV, Tsitsilonis O, Skaltsa H Tags: Curr Med Chem Source Type: research

An up-to-date review on bio-resource therapeutics effective against bacterial species frequently associated with chronic sinusitis and tonsillitis.
Abstract Infections of the upper respiratory tract include inflammations of the nose, sinuses (sinusitis), pharynx (tonsillitis, pharyngitis) and larynx (laryngitis) with bacteria or viruses as the main cause of these conditions. Due to their repetitive nature, chronic respiratory infections represent a global problem which is often a result of an improper treatment. If not treated adequately, these conditions may have serious consequences. On the other hand, mis - and overuse of antibiotics has reduced their efficiency and accelerated the development of resistant bacterial strains, which further complicates the t...
Source: Current Medicinal Chemistry - May 4, 2020 Category: Chemistry Authors: Kostić M, Ivanov M, Babić SS, Petrović J, Soković M, Ćirić A Tags: Curr Med Chem Source Type: research

In silico modelling in the development of novel radiolabelled peptide probes.
Abstract This review describes the usefulness of in silico design approaches in the design of new radiopharmaceuticals; especially peptide-based radiotracers (including peptidomimetics). Although not part of the standard arsenal utilized during radiopharmaceutical design, the use of in silico strategies is steadily increasing in the field of radiochemistry as it contributes to a more rational and scientific approach. The development of new peptide-based radiopharmaceuticals as well as a short introduction to suitable computational approaches are provided in this review. The first section comprises a concise overvi...
Source: Current Medicinal Chemistry - May 3, 2020 Category: Chemistry Authors: Kleynhans J, Kruger HG, Cloete T, Zeevaart JR, Ebenhan T Tags: Curr Med Chem Source Type: research

Targeting mammalian target of rapamycin: prospects for the treatment of inflammatory bowel diseases.
Abstract Inflammatory bowel disease (IBD) is a general term for a group of chronic and progressive disorders. Several cellular and biomolecular pathways are implicated in the pathogenesis of IBD, yet the etiology is unclear. Activation of the mammalian target of rapamycin (mTOR) pathway in the intestinal epithelial cells was also shown to induce inflammation. This review focuses on the inhibition of the mTOR signaling pathway and its potential application in treating IBD. We also provide an overview on plant-derived compounds that are beneficial for the IBD management through modulation of the mTOR pathway. Data w...
Source: Current Medicinal Chemistry - May 3, 2020 Category: Chemistry Authors: Lashgari NA, Roudsari NM, Momtaz S, Ghanaatian N, Kohansal P, Farzaei MH, Afshari K, Sahebkar A, Abdolghaffari AH Tags: Curr Med Chem Source Type: research

Voltage Gated Sodium Channel Blockers: Synthesis of Mexiletine Analogues and Homologues.
Abstract Mexiletine is an antiarrhythmic drug belonging to IB class, acting as sodium channel blocker. Besides its well-known activity on arrhythmias, its usefulness in the treatment of myotonia, myotonic distrophy and amyotrophic lateral sclerosis is now widely recognized. Nevertheless, it has been retired from the market in several countries because of its undesired effects. Thus, several papers were reported in the last years about analogues and homologues of mexiletine being endowed with a wider therapeutic ratio and a more selectivity of action. Some of them showed sodium channel blocking activity higher than...
Source: Current Medicinal Chemistry - May 3, 2020 Category: Chemistry Authors: Catalano A, Franchini C, Carocci A Tags: Curr Med Chem Source Type: research

Biochemical markers in the prediction of contrast-induced acute kidney injury.
ysz J Abstract For many years clinicians have been searching for "kidney troponin"- a simple diagnostic tool to assess risk of acute kidney injury (AKI). Recently, the rise in the variety of contrast-related procedures (contrast computed tomography [CT], percutaneous coronary intervention [PCI] and angiography) have resulted in increased number of contrast-induced acute kidney injuries (CI-AKI). CI-AKI remains important cause of overall mortality, prolonged hospitalization and it increases total costs of therapy. The consequences of kidney dysfunction affect the quality of life and they may lead to disab...
Source: Current Medicinal Chemistry - May 1, 2020 Category: Chemistry Authors: Zdziechowska M, Gluba-Brzózka A, Franczyk B, Rysz J Tags: Curr Med Chem Source Type: research

Therapy Based on the Regulation of Thiol-dependent Redox Systems.
PMID: 32345191 [PubMed - in process] (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - April 30, 2020 Category: Chemistry Authors: Lu J Tags: Curr Med Chem Source Type: research

Dysregulation of Carnosine Metabolism in Progression of Diseases.
PMID: 32340600 [PubMed - in process] (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - April 29, 2020 Category: Chemistry Authors: Bozko M, Drozak J, Malek NP, Bozko P Tags: Curr Med Chem Source Type: research