Therapeutic Potential of Lymphoid Infiltrates in Breast Cancer
Curr Med Chem. 2021 Apr 30. doi: 10.2174/0929867328666210430132701. Online ahead of print.ABSTRACTDespite diagnostic and therapeutic advances in breast cancer, it remains the most frequently diagnosed malignancy in females, with the highest cancer-related mortality rate in women globally. With an improved understanding of the complex interactions between breast cancer and the immune system, immunotherapy has shown great potential in clinical management, potentially adding to current treatment modalities. These immunotherapeutic approaches include adoptive cell transfer therapy, cancer vaccination, monoclonal antibody thera...
Source: Current Medicinal Chemistry - May 3, 2021 Category: Chemistry Authors: Xiao-Yang Chen Puay Hoon Tan Source Type: research

Dietary Phytochemicals in Cancer Signalling Pathways: Role of miRNA targeting
Curr Med Chem. 2021 Apr 19. doi: 10.2174/0929867328666210420101605. Online ahead of print.ABSTRACTCancer is a multi-factorial health condition involving uncontrolled cell divisions. The disease has its roots in genetic mutation. This disease affects men, women, and even children. Chemotherapy, photodynamic, photothermal, and hormonal therapies have been used to treat this deadliest disease but a huge percentage of patients have chances of disease recurrence or resistance. Nowadays dysregulation in miRNAs is considered one of the key factors for the development and progression of different types of cancers as they control t...
Source: Current Medicinal Chemistry - April 21, 2021 Category: Chemistry Authors: Ambreen Shoaib Mohammad Tabish Shafat Ali Azher Arafah Muneeb U Rehman Shadma Wahab Feras M Al-Marshadh Summya Rashid Source Type: research

SARS-CoV-2 Entry inhibitors targeting virus-ACE2 or virus-TMPRSS2 interactions
Curr Med Chem. 2021 Apr 19. doi: 10.2174/0929867328666210420103021. Online ahead of print.ABSTRACTCOVID-19 is an infectious disease caused by SARS-CoV-2. The life cycle of SARS-CoV-2 includes the entry into the target cells, replicase translation, replicating and transcribing genomes, translating structural proteins, assembling and releasing new virions. Entering host cells is a crucial stage in the early life cycle of the virus, and blocking this stage can effectively prevent virus infection. SARS enters the target cells mediated by the interaction between the viral S protein and the target cell surface receptor angiotens...
Source: Current Medicinal Chemistry - April 21, 2021 Category: Chemistry Authors: Hao Lin Srinivasulu Cherukupalli Da Feng Shenghua Gao Dongwei Kang Peng Zhan Xinyong Liu Source Type: research

Encapsulation of lipid-based formulations in porous carriers for controlled drug delivery
Curr Med Chem. 2021 Apr 19. doi: 10.2174/0929867328666210420103841. Online ahead of print.ABSTRACTLipid-based formulations have recently been investigated as a promising approach to enhance the bioavailability of drugs, especially poorly water-soluble drugs. The encapsulation of lipid-based formulations in porous materials can result in a transformation of liquids or semisolid forms to solid dosage forms. Moreover, the specific structure of porous carriers could offer an enhanced ability to load and control active pharmaceutical ingredients. Although there have been prominent reports on lipid-based formulations and porous ...
Source: Current Medicinal Chemistry - April 21, 2021 Category: Chemistry Authors: Phuong H L Tran Thao T D Tran Source Type: research

Dietary Phytochemicals in Cancer Signalling Pathways: Role of miRNA targeting
Curr Med Chem. 2021 Apr 19. doi: 10.2174/0929867328666210420101605. Online ahead of print.ABSTRACTCancer is a multi-factorial health condition involving uncontrolled cell divisions. The disease has its roots in genetic mutation. This disease affects men, women, and even children. Chemotherapy, photodynamic, photothermal, and hormonal therapies have been used to treat this deadliest disease but a huge percentage of patients have chances of disease recurrence or resistance. Nowadays dysregulation in miRNAs is considered one of the key factors for the development and progression of different types of cancers as they control t...
Source: Current Medicinal Chemistry - April 21, 2021 Category: Chemistry Authors: Ambreen Shoaib Mohammad Tabish Shafat Ali Azher Arafah Muneeb U Rehman Shadma Wahab Feras M Al-Marshadh Summya Rashid Source Type: research

SARS-CoV-2 Entry inhibitors targeting virus-ACE2 or virus-TMPRSS2 interactions
Curr Med Chem. 2021 Apr 19. doi: 10.2174/0929867328666210420103021. Online ahead of print.ABSTRACTCOVID-19 is an infectious disease caused by SARS-CoV-2. The life cycle of SARS-CoV-2 includes the entry into the target cells, replicase translation, replicating and transcribing genomes, translating structural proteins, assembling and releasing new virions. Entering host cells is a crucial stage in the early life cycle of the virus, and blocking this stage can effectively prevent virus infection. SARS enters the target cells mediated by the interaction between the viral S protein and the target cell surface receptor angiotens...
Source: Current Medicinal Chemistry - April 21, 2021 Category: Chemistry Authors: Hao Lin Srinivasulu Cherukupalli Da Feng Shenghua Gao Dongwei Kang Peng Zhan Xinyong Liu Source Type: research

Encapsulation of lipid-based formulations in porous carriers for controlled drug delivery
Curr Med Chem. 2021 Apr 19. doi: 10.2174/0929867328666210420103841. Online ahead of print.ABSTRACTLipid-based formulations have recently been investigated as a promising approach to enhance the bioavailability of drugs, especially poorly water-soluble drugs. The encapsulation of lipid-based formulations in porous materials can result in a transformation of liquids or semisolid forms to solid dosage forms. Moreover, the specific structure of porous carriers could offer an enhanced ability to load and control active pharmaceutical ingredients. Although there have been prominent reports on lipid-based formulations and porous ...
Source: Current Medicinal Chemistry - April 21, 2021 Category: Chemistry Authors: Phuong H L Tran Thao T D Tran Source Type: research

Dietary Phytochemicals in Cancer Signalling Pathways: Role of miRNA targeting
Curr Med Chem. 2021 Apr 19. doi: 10.2174/0929867328666210420101605. Online ahead of print.ABSTRACTCancer is a multi-factorial health condition involving uncontrolled cell divisions. The disease has its roots in genetic mutation. This disease affects men, women, and even children. Chemotherapy, photodynamic, photothermal, and hormonal therapies have been used to treat this deadliest disease but a huge percentage of patients have chances of disease recurrence or resistance. Nowadays dysregulation in miRNAs is considered one of the key factors for the development and progression of different types of cancers as they control t...
Source: Current Medicinal Chemistry - April 21, 2021 Category: Chemistry Authors: Ambreen Shoaib Mohammad Tabish Shafat Ali Azher Arafah Muneeb U Rehman Shadma Wahab Feras M Al-Marshadh Summya Rashid Source Type: research

SARS-CoV-2 Entry inhibitors targeting virus-ACE2 or virus-TMPRSS2 interactions
Curr Med Chem. 2021 Apr 19. doi: 10.2174/0929867328666210420103021. Online ahead of print.ABSTRACTCOVID-19 is an infectious disease caused by SARS-CoV-2. The life cycle of SARS-CoV-2 includes the entry into the target cells, replicase translation, replicating and transcribing genomes, translating structural proteins, assembling and releasing new virions. Entering host cells is a crucial stage in the early life cycle of the virus, and blocking this stage can effectively prevent virus infection. SARS enters the target cells mediated by the interaction between the viral S protein and the target cell surface receptor angiotens...
Source: Current Medicinal Chemistry - April 21, 2021 Category: Chemistry Authors: Hao Lin Srinivasulu Cherukupalli Da Feng Shenghua Gao Dongwei Kang Peng Zhan Xinyong Liu Source Type: research

Encapsulation of lipid-based formulations in porous carriers for controlled drug delivery
Curr Med Chem. 2021 Apr 19. doi: 10.2174/0929867328666210420103841. Online ahead of print.ABSTRACTLipid-based formulations have recently been investigated as a promising approach to enhance the bioavailability of drugs, especially poorly water-soluble drugs. The encapsulation of lipid-based formulations in porous materials can result in a transformation of liquids or semisolid forms to solid dosage forms. Moreover, the specific structure of porous carriers could offer an enhanced ability to load and control active pharmaceutical ingredients. Although there have been prominent reports on lipid-based formulations and porous ...
Source: Current Medicinal Chemistry - April 21, 2021 Category: Chemistry Authors: Phuong H L Tran Thao T D Tran Source Type: research

Dietary Phytochemicals in Cancer Signalling Pathways: Role of miRNA targeting
Curr Med Chem. 2021 Apr 19. doi: 10.2174/0929867328666210420101605. Online ahead of print.ABSTRACTCancer is a multi-factorial health condition involving uncontrolled cell divisions. The disease has its roots in genetic mutation. This disease affects men, women, and even children. Chemotherapy, photodynamic, photothermal, and hormonal therapies have been used to treat this deadliest disease but a huge percentage of patients have chances of disease recurrence or resistance. Nowadays dysregulation in miRNAs is considered one of the key factors for the development and progression of different types of cancers as they control t...
Source: Current Medicinal Chemistry - April 21, 2021 Category: Chemistry Authors: Ambreen Shoaib Mohammad Tabish Shafat Ali Azher Arafah Muneeb U Rehman Shadma Wahab Feras M Al-Marshadh Summya Rashid Source Type: research

SARS-CoV-2 Entry inhibitors targeting virus-ACE2 or virus-TMPRSS2 interactions
Curr Med Chem. 2021 Apr 19. doi: 10.2174/0929867328666210420103021. Online ahead of print.ABSTRACTCOVID-19 is an infectious disease caused by SARS-CoV-2. The life cycle of SARS-CoV-2 includes the entry into the target cells, replicase translation, replicating and transcribing genomes, translating structural proteins, assembling and releasing new virions. Entering host cells is a crucial stage in the early life cycle of the virus, and blocking this stage can effectively prevent virus infection. SARS enters the target cells mediated by the interaction between the viral S protein and the target cell surface receptor angiotens...
Source: Current Medicinal Chemistry - April 21, 2021 Category: Chemistry Authors: Hao Lin Srinivasulu Cherukupalli Da Feng Shenghua Gao Dongwei Kang Peng Zhan Xinyong Liu Source Type: research

Encapsulation of lipid-based formulations in porous carriers for controlled drug delivery
Curr Med Chem. 2021 Apr 19. doi: 10.2174/0929867328666210420103841. Online ahead of print.ABSTRACTLipid-based formulations have recently been investigated as a promising approach to enhance the bioavailability of drugs, especially poorly water-soluble drugs. The encapsulation of lipid-based formulations in porous materials can result in a transformation of liquids or semisolid forms to solid dosage forms. Moreover, the specific structure of porous carriers could offer an enhanced ability to load and control active pharmaceutical ingredients. Although there have been prominent reports on lipid-based formulations and porous ...
Source: Current Medicinal Chemistry - April 21, 2021 Category: Chemistry Authors: Phuong H L Tran Thao T D Tran Source Type: research

Dietary Phytochemicals in Cancer Signalling Pathways: Role of miRNA targeting
Curr Med Chem. 2021 Apr 19. doi: 10.2174/0929867328666210420101605. Online ahead of print.ABSTRACTCancer is a multi-factorial health condition involving uncontrolled cell divisions. The disease has its roots in genetic mutation. This disease affects men, women, and even children. Chemotherapy, photodynamic, photothermal, and hormonal therapies have been used to treat this deadliest disease but a huge percentage of patients have chances of disease recurrence or resistance. Nowadays dysregulation in miRNAs is considered one of the key factors for the development and progression of different types of cancers as they control t...
Source: Current Medicinal Chemistry - April 21, 2021 Category: Chemistry Authors: Ambreen Shoaib Mohammad Tabish Shafat Ali Azher Arafah Muneeb U Rehman Shadma Wahab Feras M Al-Marshadh Summya Rashid Source Type: research

SARS-CoV-2 Entry inhibitors targeting virus-ACE2 or virus-TMPRSS2 interactions
Curr Med Chem. 2021 Apr 19. doi: 10.2174/0929867328666210420103021. Online ahead of print.ABSTRACTCOVID-19 is an infectious disease caused by SARS-CoV-2. The life cycle of SARS-CoV-2 includes the entry into the target cells, replicase translation, replicating and transcribing genomes, translating structural proteins, assembling and releasing new virions. Entering host cells is a crucial stage in the early life cycle of the virus, and blocking this stage can effectively prevent virus infection. SARS enters the target cells mediated by the interaction between the viral S protein and the target cell surface receptor angiotens...
Source: Current Medicinal Chemistry - April 21, 2021 Category: Chemistry Authors: Hao Lin Srinivasulu Cherukupalli Da Feng Shenghua Gao Dongwei Kang Peng Zhan Xinyong Liu Source Type: research

Encapsulation of lipid-based formulations in porous carriers for controlled drug delivery
Curr Med Chem. 2021 Apr 19. doi: 10.2174/0929867328666210420103841. Online ahead of print.ABSTRACTLipid-based formulations have recently been investigated as a promising approach to enhance the bioavailability of drugs, especially poorly water-soluble drugs. The encapsulation of lipid-based formulations in porous materials can result in a transformation of liquids or semisolid forms to solid dosage forms. Moreover, the specific structure of porous carriers could offer an enhanced ability to load and control active pharmaceutical ingredients. Although there have been prominent reports on lipid-based formulations and porous ...
Source: Current Medicinal Chemistry - April 21, 2021 Category: Chemistry Authors: Phuong H L Tran Thao T D Tran Source Type: research

Dietary Phytochemicals in Cancer Signalling Pathways: Role of miRNA targeting
Curr Med Chem. 2021 Apr 19. doi: 10.2174/0929867328666210420101605. Online ahead of print.ABSTRACTCancer is a multi-factorial health condition involving uncontrolled cell divisions. The disease has its roots in genetic mutation. This disease affects men, women, and even children. Chemotherapy, photodynamic, photothermal, and hormonal therapies have been used to treat this deadliest disease but a huge percentage of patients have chances of disease recurrence or resistance. Nowadays dysregulation in miRNAs is considered one of the key factors for the development and progression of different types of cancers as they control t...
Source: Current Medicinal Chemistry - April 21, 2021 Category: Chemistry Authors: Ambreen Shoaib Mohammad Tabish Shafat Ali Azher Arafah Muneeb U Rehman Shadma Wahab Feras M Al-Marshadh Summya Rashid Source Type: research

SARS-CoV-2 Entry inhibitors targeting virus-ACE2 or virus-TMPRSS2 interactions
Curr Med Chem. 2021 Apr 19. doi: 10.2174/0929867328666210420103021. Online ahead of print.ABSTRACTCOVID-19 is an infectious disease caused by SARS-CoV-2. The life cycle of SARS-CoV-2 includes the entry into the target cells, replicase translation, replicating and transcribing genomes, translating structural proteins, assembling and releasing new virions. Entering host cells is a crucial stage in the early life cycle of the virus, and blocking this stage can effectively prevent virus infection. SARS enters the target cells mediated by the interaction between the viral S protein and the target cell surface receptor angiotens...
Source: Current Medicinal Chemistry - April 21, 2021 Category: Chemistry Authors: Hao Lin Srinivasulu Cherukupalli Da Feng Shenghua Gao Dongwei Kang Peng Zhan Xinyong Liu Source Type: research

Encapsulation of lipid-based formulations in porous carriers for controlled drug delivery
Curr Med Chem. 2021 Apr 19. doi: 10.2174/0929867328666210420103841. Online ahead of print.ABSTRACTLipid-based formulations have recently been investigated as a promising approach to enhance the bioavailability of drugs, especially poorly water-soluble drugs. The encapsulation of lipid-based formulations in porous materials can result in a transformation of liquids or semisolid forms to solid dosage forms. Moreover, the specific structure of porous carriers could offer an enhanced ability to load and control active pharmaceutical ingredients. Although there have been prominent reports on lipid-based formulations and porous ...
Source: Current Medicinal Chemistry - April 21, 2021 Category: Chemistry Authors: Phuong H L Tran Thao T D Tran Source Type: research

Dietary Phytochemicals in Cancer Signalling Pathways: Role of miRNA targeting
Curr Med Chem. 2021 Apr 19. doi: 10.2174/0929867328666210420101605. Online ahead of print.ABSTRACTCancer is a multi-factorial health condition involving uncontrolled cell divisions. The disease has its roots in genetic mutation. This disease affects men, women, and even children. Chemotherapy, photodynamic, photothermal, and hormonal therapies have been used to treat this deadliest disease but a huge percentage of patients have chances of disease recurrence or resistance. Nowadays dysregulation in miRNAs is considered one of the key factors for the development and progression of different types of cancers as they control t...
Source: Current Medicinal Chemistry - April 21, 2021 Category: Chemistry Authors: Ambreen Shoaib Mohammad Tabish Shafat Ali Azher Arafah Muneeb U Rehman Shadma Wahab Feras M Al-Marshadh Summya Rashid Source Type: research

SARS-CoV-2 Entry inhibitors targeting virus-ACE2 or virus-TMPRSS2 interactions
Curr Med Chem. 2021 Apr 19. doi: 10.2174/0929867328666210420103021. Online ahead of print.ABSTRACTCOVID-19 is an infectious disease caused by SARS-CoV-2. The life cycle of SARS-CoV-2 includes the entry into the target cells, replicase translation, replicating and transcribing genomes, translating structural proteins, assembling and releasing new virions. Entering host cells is a crucial stage in the early life cycle of the virus, and blocking this stage can effectively prevent virus infection. SARS enters the target cells mediated by the interaction between the viral S protein and the target cell surface receptor angiotens...
Source: Current Medicinal Chemistry - April 21, 2021 Category: Chemistry Authors: Hao Lin Srinivasulu Cherukupalli Da Feng Shenghua Gao Dongwei Kang Peng Zhan Xinyong Liu Source Type: research

Encapsulation of lipid-based formulations in porous carriers for controlled drug delivery
Curr Med Chem. 2021 Apr 19. doi: 10.2174/0929867328666210420103841. Online ahead of print.ABSTRACTLipid-based formulations have recently been investigated as a promising approach to enhance the bioavailability of drugs, especially poorly water-soluble drugs. The encapsulation of lipid-based formulations in porous materials can result in a transformation of liquids or semisolid forms to solid dosage forms. Moreover, the specific structure of porous carriers could offer an enhanced ability to load and control active pharmaceutical ingredients. Although there have been prominent reports on lipid-based formulations and porous ...
Source: Current Medicinal Chemistry - April 21, 2021 Category: Chemistry Authors: Phuong H L Tran Thao T D Tran Source Type: research

Dietary Phytochemicals in Cancer Signalling Pathways: Role of miRNA targeting
Curr Med Chem. 2021 Apr 19. doi: 10.2174/0929867328666210420101605. Online ahead of print.ABSTRACTCancer is a multi-factorial health condition involving uncontrolled cell divisions. The disease has its roots in genetic mutation. This disease affects men, women, and even children. Chemotherapy, photodynamic, photothermal, and hormonal therapies have been used to treat this deadliest disease but a huge percentage of patients have chances of disease recurrence or resistance. Nowadays dysregulation in miRNAs is considered one of the key factors for the development and progression of different types of cancers as they control t...
Source: Current Medicinal Chemistry - April 21, 2021 Category: Chemistry Authors: Ambreen Shoaib Mohammad Tabish Shafat Ali Azher Arafah Muneeb U Rehman Shadma Wahab Feras M Al-Marshadh Summya Rashid Source Type: research

SARS-CoV-2 Entry inhibitors targeting virus-ACE2 or virus-TMPRSS2 interactions
Curr Med Chem. 2021 Apr 19. doi: 10.2174/0929867328666210420103021. Online ahead of print.ABSTRACTCOVID-19 is an infectious disease caused by SARS-CoV-2. The life cycle of SARS-CoV-2 includes the entry into the target cells, replicase translation, replicating and transcribing genomes, translating structural proteins, assembling and releasing new virions. Entering host cells is a crucial stage in the early life cycle of the virus, and blocking this stage can effectively prevent virus infection. SARS enters the target cells mediated by the interaction between the viral S protein and the target cell surface receptor angiotens...
Source: Current Medicinal Chemistry - April 21, 2021 Category: Chemistry Authors: Hao Lin Srinivasulu Cherukupalli Da Feng Shenghua Gao Dongwei Kang Peng Zhan Xinyong Liu Source Type: research

Encapsulation of lipid-based formulations in porous carriers for controlled drug delivery
Curr Med Chem. 2021 Apr 19. doi: 10.2174/0929867328666210420103841. Online ahead of print.ABSTRACTLipid-based formulations have recently been investigated as a promising approach to enhance the bioavailability of drugs, especially poorly water-soluble drugs. The encapsulation of lipid-based formulations in porous materials can result in a transformation of liquids or semisolid forms to solid dosage forms. Moreover, the specific structure of porous carriers could offer an enhanced ability to load and control active pharmaceutical ingredients. Although there have been prominent reports on lipid-based formulations and porous ...
Source: Current Medicinal Chemistry - April 21, 2021 Category: Chemistry Authors: Phuong H L Tran Thao T D Tran Source Type: research

Dietary Phytochemicals in Cancer Signalling Pathways: Role of miRNA targeting
Curr Med Chem. 2021 Apr 19. doi: 10.2174/0929867328666210420101605. Online ahead of print.ABSTRACTCancer is a multi-factorial health condition involving uncontrolled cell divisions. The disease has its roots in genetic mutation. This disease affects men, women, and even children. Chemotherapy, photodynamic, photothermal, and hormonal therapies have been used to treat this deadliest disease but a huge percentage of patients have chances of disease recurrence or resistance. Nowadays dysregulation in miRNAs is considered one of the key factors for the development and progression of different types of cancers as they control t...
Source: Current Medicinal Chemistry - April 21, 2021 Category: Chemistry Authors: Ambreen Shoaib Mohammad Tabish Shafat Ali Azher Arafah Muneeb U Rehman Shadma Wahab Feras M Al-Marshadh Summya Rashid Source Type: research

SARS-CoV-2 Entry inhibitors targeting virus-ACE2 or virus-TMPRSS2 interactions
Curr Med Chem. 2021 Apr 19. doi: 10.2174/0929867328666210420103021. Online ahead of print.ABSTRACTCOVID-19 is an infectious disease caused by SARS-CoV-2. The life cycle of SARS-CoV-2 includes the entry into the target cells, replicase translation, replicating and transcribing genomes, translating structural proteins, assembling and releasing new virions. Entering host cells is a crucial stage in the early life cycle of the virus, and blocking this stage can effectively prevent virus infection. SARS enters the target cells mediated by the interaction between the viral S protein and the target cell surface receptor angiotens...
Source: Current Medicinal Chemistry - April 21, 2021 Category: Chemistry Authors: Hao Lin Srinivasulu Cherukupalli Da Feng Shenghua Gao Dongwei Kang Peng Zhan Xinyong Liu Source Type: research

Encapsulation of lipid-based formulations in porous carriers for controlled drug delivery
Curr Med Chem. 2021 Apr 19. doi: 10.2174/0929867328666210420103841. Online ahead of print.ABSTRACTLipid-based formulations have recently been investigated as a promising approach to enhance the bioavailability of drugs, especially poorly water-soluble drugs. The encapsulation of lipid-based formulations in porous materials can result in a transformation of liquids or semisolid forms to solid dosage forms. Moreover, the specific structure of porous carriers could offer an enhanced ability to load and control active pharmaceutical ingredients. Although there have been prominent reports on lipid-based formulations and porous ...
Source: Current Medicinal Chemistry - April 21, 2021 Category: Chemistry Authors: Phuong H L Tran Thao T D Tran Source Type: research

Notch Signaling Pathway: Find New Channel during Liver Repair and Regeneration
Curr Med Chem. 2021 Apr 19. doi: 10.2174/0929867328666210419123200. Online ahead of print.ABSTRACTThe liver is one of the significant regenerative organs in the body. Nevertheless, underlying molecular mechanisms regulating liver repair and regeneration following resection or damage remain largely unknown. The Notch signaling pathway is a profoundly evolutionarily well-conserved cell signaling system that plays mostly in multicellular organisms' development. Malfunctions in this pathway lead to the progression of several liver disorders, including hepatoblastoma (HB), cholangiocarcinoma (CCA), hepatocellular carcinoma (HCC...
Source: Current Medicinal Chemistry - April 20, 2021 Category: Chemistry Authors: Amir Valizadeh Ali Sayadmanesh Zatollah Asemi Forough Alemi Ata Mahmoodpoor Bahman Yousefi Source Type: research

Three-dimensional Printing-Driving Liver Therapies
Curr Med Chem. 2021 Apr 19. doi: 10.2174/0929867328666210419124246. Online ahead of print.ABSTRACTEnd-stage liver diseases have long been a threat to human health, and so far, the treatment of these diseases lacks of effective means. Allogenic organ transplantation has become the last straw for most of the patients with end-stage liver diseases. However, this technique has been greatly limited by the serious shortage of donors and other factors, such as immune rejection, drug syndrome, and high cost. Recently, the emergence of three-dimensional (3D) bioprinting technologies, together with the magnetic resonance imaging (MR...
Source: Current Medicinal Chemistry - April 20, 2021 Category: Chemistry Authors: Xiaohong Li Liang Wen Jiao Liu Xiaohong Wang Source Type: research

Regulating inflammation associated Ferroptosis-a treatment strategy for Parkinson disease
Curr Med Chem. 2021 Apr 19. doi: 10.2174/0929867328666210419125032. Online ahead of print.ABSTRACTFerroptosis plays a critical regulatory role for a new kind of cell death initiating and developing an array of disorders like neurological diseases, acute injury of kidney, tumors and ischemia etc. This selective deposition of iron is one of the pathogenic reasons for PD and although it's underlying mechanism is still unknown. In this review, the role of neuroinflammation in Parkinson's disease (PD) leading to neurodegeneration has been discussed in detail. The accumulation of brain iron has been found in many chronic neurolo...
Source: Current Medicinal Chemistry - April 20, 2021 Category: Chemistry Authors: Marthandam Asokan Shibu B Mahalakshmi V Bharath Kumar Source Type: research

Regulation of Protein Synthesis: an Approach to Treat Autistic Spectrum Disorder (ASD)
Curr Med Chem. 2021 Apr 19. doi: 10.2174/0929867328666210419125634. Online ahead of print.ABSTRACTAutistic Spectrum Disorder (ASD) is a disorder with different etiologies and poor elucidation, characterized by changes in social and cognitive skills. ASD has been characterized that affect large numbers of people in the world. In spite of its great importance, surprisingly just a modest progress has been achieved toward comprehending this pathology and designing new therapies. The molecular dysfunctions observed in people with autism are evidenced by the interference in the synthesis of synaptic proteins, which impairs thei...
Source: Current Medicinal Chemistry - April 20, 2021 Category: Chemistry Authors: J éssika Poliana Teixeira Teodorico Castro Ramalho Source Type: research

Association of homocysteine level with adverse outcomes in patients with acute ischemic stroke: A meta-analysis
CONCLUSION: Elevated homocysteine level is independently associated with a higher risk of all-cause mortality but not recurrent stroke or poor functional outcome in patients with AIS. However, additional well-designed studies are required to confirm the findings of this meta-analysis.PMID:33874865 | DOI:10.2174/0929867328666210419131016 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - April 20, 2021 Category: Chemistry Authors: Heng Zhang Jiabin Huang Yongjing Zhou Yu Fan Source Type: research

The Role of Cholesterol Homeostasis in Diabetic Kidney Disease
Curr Med Chem. 2021 Apr 19. doi: 10.2174/0929867328666210419132807. Online ahead of print.ABSTRACTConsiderable evidence has proved that disturbed cholesterol metabolism played a crucial role in diabetic kidney disease. Besides, massive cholesterol depositions were found in intrinsic renal cells of diabetic kidney disease patients and animal models, causing cytotoxicity, and affecting renal function. Statins could alleviate cholesterol depositions, podocyte injury and microalbuminuria of diabetic kidney disease. In the review, we summarized the process of disturbed cholesterol metabolism and discussed how it induced kidney ...
Source: Current Medicinal Chemistry - April 20, 2021 Category: Chemistry Authors: Xinyun Chen Qinghua Yin Liang Ma Ping Fu Source Type: research

Characterizing the relationship between the chemical structures of drugs and their activities on primary cultures of pediatric solid tumors
CONCLUSION: It is possible to identify privileged chemical scaffolds and predict the in vitro potency of unseen molecules across these 30 targets This information and models should be helpful to select which molecules to screen against these primary cultures of pediatric solid tumors.PMID:33874867 | DOI:10.2174/0929867328666210419134708 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - April 20, 2021 Category: Chemistry Authors: Saw Simeon Ghita Ghislat Pedro Ballester Source Type: research

Advances in polyaniline for biomedical applications
Curr Med Chem. 2021 Apr 19. doi: 10.2174/0929867328666210419135519. Online ahead of print.ABSTRACTConducting polymers are an outstanding class of materials characterized by electroconducting properties that make them good candidates for applications in several sectors. Among them, polyaniline (PANI) is unique for its extraordinary ability to conduct electricity, biocompatibility and low toxicity. In spite of its surprising features, to date PANI have not yet found application in the practical uses, because of its low solubility and processability. In order to overcome these limitations, different approaches have been devel...
Source: Current Medicinal Chemistry - April 20, 2021 Category: Chemistry Authors: Cristina Della Pina Ermelinda Falletta Source Type: research

Notch Signaling Pathway: Find New Channel during Liver Repair and Regeneration
Curr Med Chem. 2021 Apr 19. doi: 10.2174/0929867328666210419123200. Online ahead of print.ABSTRACTThe liver is one of the significant regenerative organs in the body. Nevertheless, underlying molecular mechanisms regulating liver repair and regeneration following resection or damage remain largely unknown. The Notch signaling pathway is a profoundly evolutionarily well-conserved cell signaling system that plays mostly in multicellular organisms' development. Malfunctions in this pathway lead to the progression of several liver disorders, including hepatoblastoma (HB), cholangiocarcinoma (CCA), hepatocellular carcinoma (HCC...
Source: Current Medicinal Chemistry - April 20, 2021 Category: Chemistry Authors: Amir Valizadeh Ali Sayadmanesh Zatollah Asemi Forough Alemi Ata Mahmoodpoor Bahman Yousefi Source Type: research

Three-dimensional Printing-Driving Liver Therapies
Curr Med Chem. 2021 Apr 19. doi: 10.2174/0929867328666210419124246. Online ahead of print.ABSTRACTEnd-stage liver diseases have long been a threat to human health, and so far, the treatment of these diseases lacks of effective means. Allogenic organ transplantation has become the last straw for most of the patients with end-stage liver diseases. However, this technique has been greatly limited by the serious shortage of donors and other factors, such as immune rejection, drug syndrome, and high cost. Recently, the emergence of three-dimensional (3D) bioprinting technologies, together with the magnetic resonance imaging (MR...
Source: Current Medicinal Chemistry - April 20, 2021 Category: Chemistry Authors: Xiaohong Li Liang Wen Jiao Liu Xiaohong Wang Source Type: research

Regulating inflammation associated Ferroptosis-a treatment strategy for Parkinson disease
Curr Med Chem. 2021 Apr 19. doi: 10.2174/0929867328666210419125032. Online ahead of print.ABSTRACTFerroptosis plays a critical regulatory role for a new kind of cell death initiating and developing an array of disorders like neurological diseases, acute injury of kidney, tumors and ischemia etc. This selective deposition of iron is one of the pathogenic reasons for PD and although it's underlying mechanism is still unknown. In this review, the role of neuroinflammation in Parkinson's disease (PD) leading to neurodegeneration has been discussed in detail. The accumulation of brain iron has been found in many chronic neurolo...
Source: Current Medicinal Chemistry - April 20, 2021 Category: Chemistry Authors: Marthandam Asokan Shibu B Mahalakshmi V Bharath Kumar Source Type: research

Regulation of Protein Synthesis: an Approach to Treat Autistic Spectrum Disorder (ASD)
Curr Med Chem. 2021 Apr 19. doi: 10.2174/0929867328666210419125634. Online ahead of print.ABSTRACTAutistic Spectrum Disorder (ASD) is a disorder with different etiologies and poor elucidation, characterized by changes in social and cognitive skills. ASD has been characterized that affect large numbers of people in the world. In spite of its great importance, surprisingly just a modest progress has been achieved toward comprehending this pathology and designing new therapies. The molecular dysfunctions observed in people with autism are evidenced by the interference in the synthesis of synaptic proteins, which impairs thei...
Source: Current Medicinal Chemistry - April 20, 2021 Category: Chemistry Authors: J éssika Poliana Teixeira Teodorico Castro Ramalho Source Type: research

Association of homocysteine level with adverse outcomes in patients with acute ischemic stroke: A meta-analysis
CONCLUSION: Elevated homocysteine level is independently associated with a higher risk of all-cause mortality but not recurrent stroke or poor functional outcome in patients with AIS. However, additional well-designed studies are required to confirm the findings of this meta-analysis.PMID:33874865 | DOI:10.2174/0929867328666210419131016 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - April 20, 2021 Category: Chemistry Authors: Heng Zhang Jiabin Huang Yongjing Zhou Yu Fan Source Type: research

The Role of Cholesterol Homeostasis in Diabetic Kidney Disease
Curr Med Chem. 2021 Apr 19. doi: 10.2174/0929867328666210419132807. Online ahead of print.ABSTRACTConsiderable evidence has proved that disturbed cholesterol metabolism played a crucial role in diabetic kidney disease. Besides, massive cholesterol depositions were found in intrinsic renal cells of diabetic kidney disease patients and animal models, causing cytotoxicity, and affecting renal function. Statins could alleviate cholesterol depositions, podocyte injury and microalbuminuria of diabetic kidney disease. In the review, we summarized the process of disturbed cholesterol metabolism and discussed how it induced kidney ...
Source: Current Medicinal Chemistry - April 20, 2021 Category: Chemistry Authors: Xinyun Chen Qinghua Yin Liang Ma Ping Fu Source Type: research

Characterizing the relationship between the chemical structures of drugs and their activities on primary cultures of pediatric solid tumors
CONCLUSION: It is possible to identify privileged chemical scaffolds and predict the in vitro potency of unseen molecules across these 30 targets This information and models should be helpful to select which molecules to screen against these primary cultures of pediatric solid tumors.PMID:33874867 | DOI:10.2174/0929867328666210419134708 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - April 20, 2021 Category: Chemistry Authors: Saw Simeon Ghita Ghislat Pedro Ballester Source Type: research

Advances in polyaniline for biomedical applications
Curr Med Chem. 2021 Apr 19. doi: 10.2174/0929867328666210419135519. Online ahead of print.ABSTRACTConducting polymers are an outstanding class of materials characterized by electroconducting properties that make them good candidates for applications in several sectors. Among them, polyaniline (PANI) is unique for its extraordinary ability to conduct electricity, biocompatibility and low toxicity. In spite of its surprising features, to date PANI have not yet found application in the practical uses, because of its low solubility and processability. In order to overcome these limitations, different approaches have been devel...
Source: Current Medicinal Chemistry - April 20, 2021 Category: Chemistry Authors: Cristina Della Pina Ermelinda Falletta Source Type: research

A Review on Colorimetric Sensing of Tumor Markers Based on Enzyme-Mimicking Nanomaterials
Curr Med Chem. 2021 Apr 12. doi: 10.2174/0929867328666210412122604. Online ahead of print.ABSTRACTNanomedicine is an arising field that exploits nanotechnology concepts for pioneered therapy and diagnostics. Colorimetric sensors for tumor markers have displayed interesting benefits compared to conventional systems in clinical laboratory diagnosis. Colorimetric immunoassay based approaches show up-and-coming results since the goal cancer marker is determined with high sensitivity but without the utilize of advanced/expensive techniques through an effortless optical color change. Also, colorimetric biosensor has the potentia...
Source: Current Medicinal Chemistry - April 13, 2021 Category: Chemistry Authors: Hayati Filik Asiye Asl ıhan Avan Zehra F üsun Tokatlı Source Type: research

Structure, Function and Modulation of Striatal-enriched Protein Tyrosine Phosphatase (STEP)
Curr Med Chem. 2021 Apr 12. doi: 10.2174/0929867328666210412123304. Online ahead of print.ABSTRACTStriatal-enriched protein tyrosine phosphatase (STEP) is exclusively expressed in the central nervous system and regulates various neuronal signaling factors through the dephosphorylation of different substrates. Dysregulated expression or uncontrollable enzymatic activity of STEP contributes to neurological disorders such as Alzheimer's disease, which makes it a promising pharmaceutical target. Herein, we reviewed the structure and biological functions of STEP, as well as the recent development of small- molecule STEP modulat...
Source: Current Medicinal Chemistry - April 13, 2021 Category: Chemistry Authors: Xiao Liang Xuben Hou Hao Fang Source Type: research

Recent Insights on Biomedical Applications of Bacterial Cellulose based Composite Hydrogels
CONCLUSION: BC based composite hydrogels with the advantages of 3D structure, non-toxicity, high purity, and good biocompatibility, have great prospects in the development of sustainable and multifunctional biomaterials for biomedical applications.PMID:33845720 | DOI:10.2174/0929867328666210412124444 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - April 13, 2021 Category: Chemistry Authors: Wei Liu Haishun Du Ting Zheng Chuanling Si Source Type: research

Translational research of hemoglobin vesicles as a transfusion alternative
Curr Med Chem. 2021 Apr 12. doi: 10.2174/0929867328666210412130035. Online ahead of print.ABSTRACTClinical situations arise in which blood for transfusion becomes scarce or unavailable. Considerable demand for a transfusion alternative persists because of various difficulties posed by blood donation and transfusion systems. Hemoglobin-vesicles (HbV) are artificial oxygen carriers being developed for use as a transfusion alternative. Just as biomembranes of red blood cells (RBCs) do, phospholipid vesicles (liposomes) for Hb encapsulation can protect the human body from toxic effects of molecular Hb. The main HbV component, ...
Source: Current Medicinal Chemistry - April 13, 2021 Category: Chemistry Authors: Hiromi Sakai Naoko Kobayashi Tomoko Kure Chie Okuda Source Type: research

A Review on Colorimetric Sensing of Tumor Markers Based on Enzyme-Mimicking Nanomaterials
Curr Med Chem. 2021 Apr 12. doi: 10.2174/0929867328666210412122604. Online ahead of print.ABSTRACTNanomedicine is an arising field that exploits nanotechnology concepts for pioneered therapy and diagnostics. Colorimetric sensors for tumor markers have displayed interesting benefits compared to conventional systems in clinical laboratory diagnosis. Colorimetric immunoassay based approaches show up-and-coming results since the goal cancer marker is determined with high sensitivity but without the utilize of advanced/expensive techniques through an effortless optical color change. Also, colorimetric biosensor has the potentia...
Source: Current Medicinal Chemistry - April 13, 2021 Category: Chemistry Authors: Hayati Filik Asiye Asl ıhan Avan Zehra F üsun Tokatlı Source Type: research

Structure, Function and Modulation of Striatal-enriched Protein Tyrosine Phosphatase (STEP)
Curr Med Chem. 2021 Apr 12. doi: 10.2174/0929867328666210412123304. Online ahead of print.ABSTRACTStriatal-enriched protein tyrosine phosphatase (STEP) is exclusively expressed in the central nervous system and regulates various neuronal signaling factors through the dephosphorylation of different substrates. Dysregulated expression or uncontrollable enzymatic activity of STEP contributes to neurological disorders such as Alzheimer's disease, which makes it a promising pharmaceutical target. Herein, we reviewed the structure and biological functions of STEP, as well as the recent development of small- molecule STEP modulat...
Source: Current Medicinal Chemistry - April 13, 2021 Category: Chemistry Authors: Xiao Liang Xuben Hou Hao Fang Source Type: research