Recent Natural Anticancer Agents
Curr Med Chem. 2022;29(2):164-165. doi: 10.2174/092986732902220103145922.NO ABSTRACTPMID:35038976 | DOI:10.2174/092986732902220103145922 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - January 18, 2022 Category: Chemistry Authors: Luciana Scotti Marcus T Scotti Source Type: research

Targeted Biologics: The New Frontier for Precision Therapy
Curr Med Chem. 2022;29(3):383-384. doi: 10.2174/092986732903220103161049.NO ABSTRACTPMID:35038978 | DOI:10.2174/092986732903220103161049 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - January 18, 2022 Category: Chemistry Authors: Stefano Bruno Paul W Buehler Andrea Mozzarelli Source Type: research

Urinary miRNAs as diagnostic biomarkers for prostatic cancer: Current dilemmas and novel potential role for digital rectal examination
Curr Med Chem. 2022 Jan 18. doi: 10.2174/0929867329666220118101733. Online ahead of print.NO ABSTRACTPMID:35040397 | DOI:10.2174/0929867329666220118101733 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - January 18, 2022 Category: Chemistry Authors: Ilias Giannakodimos Source Type: research

Ferroptosis inducers for prostate cancer therapy
Curr Med Chem. 2022 Jan 11. doi: 10.2174/0929867329666220111120924. Online ahead of print.ABSTRACTLipid peroxidation-driven iron-dependent ferroptosis is a regulated cell death mechanism implicated in numerous disease, such as neurological diseases, kidney injury, ischemia, and tumors, including prostate cancer. The cellular mechanisms of ferrosptosis are strongly associated with iron, reactive oxygen species and aminoacid metabolic pathways. Several compounds, namely ferroptosis inducers, impact on these pathways and trigger ferroptosis by i) inhibiting Xc- transporter system, ii) impairing GPX4 functions and iii) oxidizi...
Source: Current Medicinal Chemistry - January 13, 2022 Category: Chemistry Authors: Nadia Zaffaroni Giovanni Luca Beretta Source Type: research

Diarylurea: A Privileged Scaffold in Drug Discovery and Therapeutic Development
Curr Med Chem. 2022 Jan 11. doi: 10.2174/0929867329666220111121251. Online ahead of print.NO ABSTRACTPMID:35021967 | DOI:10.2174/0929867329666220111121251 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - January 13, 2022 Category: Chemistry Authors: Alessia Catalano Source Type: research

Determination of Both TP53 Mutation Status and the Amount of p53 Protein Has Limited Diagnostic Importance for Patients with Ovarian Cancer
CONCLUSION: In ovarian tumors both determination of TP53 status as well as p53 protein amount has only limited diagnostic importance.PMID:35023452 | DOI:10.2174/0929867329666220112141211 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - January 13, 2022 Category: Chemistry Authors: Sebastian M Klein Maria Bozko Astrid Toennie ßen Nisar P Malek Przemyslaw Bozko Source Type: research

Ferroptosis inducers for prostate cancer therapy
Curr Med Chem. 2022 Jan 11. doi: 10.2174/0929867329666220111120924. Online ahead of print.ABSTRACTLipid peroxidation-driven iron-dependent ferroptosis is a regulated cell death mechanism implicated in numerous disease, such as neurological diseases, kidney injury, ischemia, and tumors, including prostate cancer. The cellular mechanisms of ferrosptosis are strongly associated with iron, reactive oxygen species and aminoacid metabolic pathways. Several compounds, namely ferroptosis inducers, impact on these pathways and trigger ferroptosis by i) inhibiting Xc- transporter system, ii) impairing GPX4 functions and iii) oxidizi...
Source: Current Medicinal Chemistry - January 13, 2022 Category: Chemistry Authors: Nadia Zaffaroni Giovanni Luca Beretta Source Type: research

Diarylurea: A Privileged Scaffold in Drug Discovery and Therapeutic Development
Curr Med Chem. 2022 Jan 11. doi: 10.2174/0929867329666220111121251. Online ahead of print.NO ABSTRACTPMID:35021967 | DOI:10.2174/0929867329666220111121251 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - January 13, 2022 Category: Chemistry Authors: Alessia Catalano Source Type: research

Determination of Both TP53 Mutation Status and the Amount of p53 Protein Has Limited Diagnostic Importance for Patients with Ovarian Cancer
CONCLUSION: In ovarian tumors both determination of TP53 status as well as p53 protein amount has only limited diagnostic importance.PMID:35023452 | DOI:10.2174/0929867329666220112141211 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - January 13, 2022 Category: Chemistry Authors: Sebastian M Klein Maria Bozko Astrid Toennie ßen Nisar P Malek Przemyslaw Bozko Source Type: research

Ferroptosis inducers for prostate cancer therapy
Curr Med Chem. 2022 Jan 11. doi: 10.2174/0929867329666220111120924. Online ahead of print.ABSTRACTLipid peroxidation-driven iron-dependent ferroptosis is a regulated cell death mechanism implicated in numerous disease, such as neurological diseases, kidney injury, ischemia, and tumors, including prostate cancer. The cellular mechanisms of ferrosptosis are strongly associated with iron, reactive oxygen species and aminoacid metabolic pathways. Several compounds, namely ferroptosis inducers, impact on these pathways and trigger ferroptosis by i) inhibiting Xc- transporter system, ii) impairing GPX4 functions and iii) oxidizi...
Source: Current Medicinal Chemistry - January 13, 2022 Category: Chemistry Authors: Nadia Zaffaroni Giovanni Luca Beretta Source Type: research

Diarylurea: A Privileged Scaffold in Drug Discovery and Therapeutic Development
Curr Med Chem. 2022 Jan 11. doi: 10.2174/0929867329666220111121251. Online ahead of print.NO ABSTRACTPMID:35021967 | DOI:10.2174/0929867329666220111121251 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - January 13, 2022 Category: Chemistry Authors: Alessia Catalano Source Type: research

Determination of Both TP53 Mutation Status and the Amount of p53 Protein Has Limited Diagnostic Importance for Patients with Ovarian Cancer
CONCLUSION: In ovarian tumors both determination of TP53 status as well as p53 protein amount has only limited diagnostic importance.PMID:35023452 | DOI:10.2174/0929867329666220112141211 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - January 13, 2022 Category: Chemistry Authors: Sebastian M Klein Maria Bozko Astrid Toennie ßen Nisar P Malek Przemyslaw Bozko Source Type: research

Ferroptosis inducers for prostate cancer therapy
Curr Med Chem. 2022 Jan 11. doi: 10.2174/0929867329666220111120924. Online ahead of print.ABSTRACTLipid peroxidation-driven iron-dependent ferroptosis is a regulated cell death mechanism implicated in numerous disease, such as neurological diseases, kidney injury, ischemia, and tumors, including prostate cancer. The cellular mechanisms of ferrosptosis are strongly associated with iron, reactive oxygen species and aminoacid metabolic pathways. Several compounds, namely ferroptosis inducers, impact on these pathways and trigger ferroptosis by i) inhibiting Xc- transporter system, ii) impairing GPX4 functions and iii) oxidizi...
Source: Current Medicinal Chemistry - January 13, 2022 Category: Chemistry Authors: Nadia Zaffaroni Giovanni Luca Beretta Source Type: research

Diarylurea: A Privileged Scaffold in Drug Discovery and Therapeutic Development
Curr Med Chem. 2022 Jan 11. doi: 10.2174/0929867329666220111121251. Online ahead of print.NO ABSTRACTPMID:35021967 | DOI:10.2174/0929867329666220111121251 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - January 13, 2022 Category: Chemistry Authors: Alessia Catalano Source Type: research

Determination of Both TP53 Mutation Status and the Amount of p53 Protein Has Limited Diagnostic Importance for Patients with Ovarian Cancer
CONCLUSION: In ovarian tumors both determination of TP53 status as well as p53 protein amount has only limited diagnostic importance.PMID:35023452 | DOI:10.2174/0929867329666220112141211 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - January 13, 2022 Category: Chemistry Authors: Sebastian M Klein Maria Bozko Astrid Toennie ßen Nisar P Malek Przemyslaw Bozko Source Type: research

Cucurbitacins and the Immune System: Update in Research on Anti-inflammatory, Antioxidant, and Immunomodulatory Mechanisms
Curr Med Chem. 2022 Jan 7. doi: 10.2174/0929867329666220107153253. Online ahead of print.ABSTRACTCucurbitacins are a wide group of natural products found in several plant families, especially in the Cucurbitaceae family. In the last decade, there has been a significant increase in studies aimed at identifying new biological activities of cucurbitacins and describing their mechanisms of action. The most researched pharmacological activities are antineoplastic and anti-inflammatory activity, the first being recently reviewed. The present review explains the anti-inflammatory, antioxidant, and immunomodulatory potential of cu...
Source: Current Medicinal Chemistry - January 7, 2022 Category: Chemistry Authors: Geovana F Guedes Silvestre Renally Pereira de Lucena Harley da Silva Alves Source Type: research

Polypharmacy- Purpose, Benefits and Limitations
Curr Med Chem. 2022 Jan 7. doi: 10.2174/0929867329666220107153813. Online ahead of print.ABSTRACTWith what has become increasingly common among nearly all medical specialties, the number of patients who have various comorbid diseases both psychiatrically and mentally challenges the field of psychiatry. As a result, it is not uncommon physicians are imposed with treatment decisions regarding polypharmacy- the use of multiple medications to treat either different diseases, or even many times, the same illness. In recent years the concept of polypharmacy has been known to have a negative undertone, implying its use is inappro...
Source: Current Medicinal Chemistry - January 7, 2022 Category: Chemistry Authors: Douglas Grover Michelle Tom Gerald Maguire Stephen Stahl Source Type: research

Cucurbitacins and the Immune System: Update in Research on Anti-inflammatory, Antioxidant, and Immunomodulatory Mechanisms
Curr Med Chem. 2022 Jan 7. doi: 10.2174/0929867329666220107153253. Online ahead of print.ABSTRACTCucurbitacins are a wide group of natural products found in several plant families, especially in the Cucurbitaceae family. In the last decade, there has been a significant increase in studies aimed at identifying new biological activities of cucurbitacins and describing their mechanisms of action. The most researched pharmacological activities are antineoplastic and anti-inflammatory activity, the first being recently reviewed. The present review explains the anti-inflammatory, antioxidant, and immunomodulatory potential of cu...
Source: Current Medicinal Chemistry - January 7, 2022 Category: Chemistry Authors: Geovana F Guedes Silvestre Renally Pereira de Lucena Harley da Silva Alves Source Type: research

Polypharmacy- Purpose, Benefits and Limitations
Curr Med Chem. 2022 Jan 7. doi: 10.2174/0929867329666220107153813. Online ahead of print.ABSTRACTWith what has become increasingly common among nearly all medical specialties, the number of patients who have various comorbid diseases both psychiatrically and mentally challenges the field of psychiatry. As a result, it is not uncommon physicians are imposed with treatment decisions regarding polypharmacy- the use of multiple medications to treat either different diseases, or even many times, the same illness. In recent years the concept of polypharmacy has been known to have a negative undertone, implying its use is inappro...
Source: Current Medicinal Chemistry - January 7, 2022 Category: Chemistry Authors: Douglas Grover Michelle Tom Gerald Maguire Stephen Stahl Source Type: research

Cucurbitacins and the Immune System: Update in Research on Anti-inflammatory, Antioxidant, and Immunomodulatory Mechanisms
Curr Med Chem. 2022 Jan 7. doi: 10.2174/0929867329666220107153253. Online ahead of print.ABSTRACTCucurbitacins are a wide group of natural products found in several plant families, especially in the Cucurbitaceae family. In the last decade, there has been a significant increase in studies aimed at identifying new biological activities of cucurbitacins and describing their mechanisms of action. The most researched pharmacological activities are antineoplastic and anti-inflammatory activity, the first being recently reviewed. The present review explains the anti-inflammatory, antioxidant, and immunomodulatory potential of cu...
Source: Current Medicinal Chemistry - January 7, 2022 Category: Chemistry Authors: Geovana F Guedes Silvestre Renally Pereira de Lucena Harley da Silva Alves Source Type: research

Polypharmacy- Purpose, Benefits and Limitations
Curr Med Chem. 2022 Jan 7. doi: 10.2174/0929867329666220107153813. Online ahead of print.ABSTRACTWith what has become increasingly common among nearly all medical specialties, the number of patients who have various comorbid diseases both psychiatrically and mentally challenges the field of psychiatry. As a result, it is not uncommon physicians are imposed with treatment decisions regarding polypharmacy- the use of multiple medications to treat either different diseases, or even many times, the same illness. In recent years the concept of polypharmacy has been known to have a negative undertone, implying its use is inappro...
Source: Current Medicinal Chemistry - January 7, 2022 Category: Chemistry Authors: Douglas Grover Michelle Tom Gerald Maguire Stephen Stahl Source Type: research

Cucurbitacins and the Immune System: Update in Research on Anti-inflammatory, Antioxidant, and Immunomodulatory Mechanisms
Curr Med Chem. 2022 Jan 7. doi: 10.2174/0929867329666220107153253. Online ahead of print.ABSTRACTCucurbitacins are a wide group of natural products found in several plant families, especially in the Cucurbitaceae family. In the last decade, there has been a significant increase in studies aimed at identifying new biological activities of cucurbitacins and describing their mechanisms of action. The most researched pharmacological activities are antineoplastic and anti-inflammatory activity, the first being recently reviewed. The present review explains the anti-inflammatory, antioxidant, and immunomodulatory potential of cu...
Source: Current Medicinal Chemistry - January 7, 2022 Category: Chemistry Authors: Geovana F Guedes Silvestre Renally Pereira de Lucena Harley da Silva Alves Source Type: research

Polypharmacy- Purpose, Benefits and Limitations
Curr Med Chem. 2022 Jan 7. doi: 10.2174/0929867329666220107153813. Online ahead of print.ABSTRACTWith what has become increasingly common among nearly all medical specialties, the number of patients who have various comorbid diseases both psychiatrically and mentally challenges the field of psychiatry. As a result, it is not uncommon physicians are imposed with treatment decisions regarding polypharmacy- the use of multiple medications to treat either different diseases, or even many times, the same illness. In recent years the concept of polypharmacy has been known to have a negative undertone, implying its use is inappro...
Source: Current Medicinal Chemistry - January 7, 2022 Category: Chemistry Authors: Douglas Grover Michelle Tom Gerald Maguire Stephen Stahl Source Type: research

Recent Advances in Combretastatin A-4 Inspired Inhibitors of Tubulin Polymerization-An Update
This article summarizes the new molecule development efforts to reach CA-4 analogs by modifications on its pharmacophore groups, published since 2015.PMID:34986762 | DOI:10.2174/1871526522666220105114437 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - January 6, 2022 Category: Chemistry Authors: Sultan Nacak Baytas Source Type: research

New uses of Melatonin as a Drug, a Review
Curr Med Chem. 2022 Jan 5. doi: 10.2174/0929867329666220105115755. Online ahead of print.ABSTRACTMelatonin is a simple compound with a proper chemical name N-acetyl-5-methoxy tryptamine and known as a hormone controlling circadian rhythm. Humans produce melatonin at night which is the reason for sleeping in the night and awakening over the day. Melatonin interacts with melatonin receptors MT1 and MT2 but it was also revealed that melatonin is a strong antioxidant and it also has a role in regulation of cell cycle. Currently, melatonin is used as a drug for some types of sleep disorder but the recent research points to the ...
Source: Current Medicinal Chemistry - January 6, 2022 Category: Chemistry Authors: Miroslav Pohanka Source Type: research

Molecules Containing Cyclobutyl Fragments as Therapeutic Tools: A Review on Cyclobutyl Drugs
This article provides details of the research progress of the structure types, structure-activity relationships, targets, and mechanisms of cyclobutyl drugs that have been on the market or are in the clinical stage, and provides ideas for the discovery and synthesis of novel cyclobutyl-containing drugs.PMID:34986764 | DOI:10.2174/0929867329666220105120722 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - January 6, 2022 Category: Chemistry Authors: Shuang Ren Fei Pan Wen Zhang Guo-Wu Rao Source Type: research

Host microbiomes in tumor precision medicine: how far are we?
Curr Med Chem. 2022 Jan 5. doi: 10.2174/0929867329666220105121754. Online ahead of print.ABSTRACTThe human gut microbiome has received a crescendo of attention in recent years, due to the countless influences on human pathophysiology, including cancer. Research on cancer and anticancer therapy is constantly looking for new hints to improve the response to therapy while reducing the risk of relapse. In this scenario, the gut microbiome and the plethora of microbial-derived metabolites are considered a new opening in the development of innovative anticancer treatments for a better prognosis. This narrative review summarizes ...
Source: Current Medicinal Chemistry - January 6, 2022 Category: Chemistry Authors: Federica D'Amico Monica Barone Teresa Tavella Simone Rampelli Patrizia Brigidi Silvia Turroni Source Type: research

The crosstalk between gut microbiota, intestinal immunological niche and visceral adipose tissue as a new model for the pathogenesis of metabolic and inflammatory diseases: the paradigm of type 2 diabetes mellitus
Curr Med Chem. 2022 Jan 5. doi: 10.2174/0929867329666220105121124. Online ahead of print.ABSTRACTGut microbiota (GM) comprises more than one thousand microorganisms between bacterial species, viruses, fungi, and protozoa, and represents the main actor of a wide net of molecular interactions, involving, among others, the endocrine system, immune responses, and metabolism. GM influences many endocrine functions such as adrenal steroidogenesis, thyroid function, sexual hormones, IGF-1 pathway and peptides produced in gastrointestinal system. It is fundamental in glycaemic control and obesity, while also exerting an important ...
Source: Current Medicinal Chemistry - January 6, 2022 Category: Chemistry Authors: Cianci Rossella Franza Laura Massaro Maria Grazia Borriello Raffaele Tota Antonio Pallozzi Maria De Vito Francesco Gambassi Giovanni Source Type: research

Nanoparticle mediated gene therapy: a trailblazer armament to fight CNS disorders
Curr Med Chem. 2022 Jan 5. doi: 10.2174/0929867329666220105122318. Online ahead of print.ABSTRACTCentral nervous system (CNS) disorders account for boundless socioeconomic burdens with devastating effects among the population, especially the elderly. The major symptoms of these disorders are neurodegeneration, neuroinflammation, and cognitive dysfunction caused by inherited genetic mutations or by genetic and epigenetic changes due to injury, environmental factors, and disease-related events. Currently available clinical treatment for CNS diseases, i.e., Alzheimer's disease, Parkinson's disease, stroke, and brain tumor hav...
Source: Current Medicinal Chemistry - January 6, 2022 Category: Chemistry Authors: None Annu Saleha Rehman Bushra Nabi Ali Sartaj Sanjula Baboota Shadab Md P K Sahoo Javed Ali Source Type: research

Applications of lipid-based nanocarriers for parenteral drug delivery
Curr Med Chem. 2022 Jan 4. doi: 10.2174/0929867329666220104111949. Online ahead of print.ABSTRACTThis review describes the use of Lipid-based Nanocarriers (LNCs) for the parenteral delivery of pharmaceutical actives. Firstly, the two generation of LNCs such as ''solid lipid nanoparticles'' (SLNs) and ''nanostructured lipid carriers'' (NLCs) are explained in term of preparation, characterization and stability. Although the use of LNCs through parenteral administration has shown many benefits, their use is limited by opsonization, an immune process that causes their short half-life (3-5 min). Therefore, many strategies are d...
Source: Current Medicinal Chemistry - January 5, 2022 Category: Chemistry Authors: Debora Santonocito Carmelo Puglia Source Type: research

Natural Biopolymers: Property, Modifications and Applications in Pharmaceutical Fields
Curr Med Chem. 2021;28(40):8239-8242. doi: 10.2174/092986732840211224105955.NO ABSTRACTPMID:34983339 | DOI:10.2174/092986732840211224105955 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - January 5, 2022 Category: Chemistry Authors: Chuanling Si Kun Liu Haishun Du Source Type: research

Colorectal Serrated Lesions: A Current View on Clinical, Morphological, Molecular, and Genetic Diagnostic Criteria
CONCLUSION: Although significant efforts were made in attempt to improve our understanding and diagnostic criteria of serrated polyps of colorectum, very little has changed since the original morphologic description of preneoplastic serrated lesions in early 2000s. There remains a need for more research in order to develop more definitive immuophenotypic and molecular biomarkers in order to distinguish between non-neoplastic and neoplastic serrated lesions.PMID:34984965 | DOI:10.2174/0929867328666210715125428 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - January 5, 2022 Category: Chemistry Authors: Liudmila M Mikhaleva Rositsa A Vandysheva Konstantin Yu Midiber Olesya A Vasyukova Valentina V Pechnikova Olga I Patsap Ozal Beylerli Siva G Somasundaram Cecil E Kirkland Gjumrakch Aliev Source Type: research

Biofilm formation as valuable target to fight severe chronic infections
Curr Med Chem. 2022 Jan 3. doi: 10.2174/0929867329666220103095551. Online ahead of print.NO ABSTRACTPMID:34979887 | DOI:10.2174/0929867329666220103095551 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - January 4, 2022 Category: Chemistry Authors: Camilla Pecoraro Daniela Carbone Deng Dongmei Stella Maria Cascioferro Patrizia Diana Elisa Giovannetti Source Type: research

Ιmmunity, Vascular Aging, and Stroke
Curr Med Chem. 2022 Jan 3. doi: 10.2174/0929867329666220103101700. Online ahead of print.ABSTRACTStroke is one of the most devastating manifestations of cardiovascular disease. Growing age, arterial hypertension, and atherosclerosis are identified as independent risk factors for stroke, primarily due to structural and functional alterations in the cerebrovascular tree. Recent data from in vitro and clinical studies have suggested that the immune system influences atherosclerosis, promoting vascular stiffness and vascular aging and contributing to ischemic stroke, intracranial haemorrhage and microbleeds, white matter disea...
Source: Current Medicinal Chemistry - January 4, 2022 Category: Chemistry Authors: Anna-Maria Louka Dimitrios Sagris George Ntaios Source Type: research

Role of Non-Coding RNA of Human Platelet in Cardiovascular Disease
Curr Med Chem. 2021 Dec 30. doi: 10.2174/0929867329666211230104955. Online ahead of print.ABSTRACTCardiovascular diseases (CVD) are the major cause of death in the world. Numerous genetic studies involving transcriptomic approaches aimed at the detailed understanding of the disease and the development of new therapeutic strategies have been conducted over recent years. There has been an increase in research on platelets, which are implicated in CVD due to their capacity to release regulatory molecules that affect various pathways. Platelets secrete over 500 various kinds of molecules to plasma including large amounts of no...
Source: Current Medicinal Chemistry - December 30, 2021 Category: Chemistry Authors: None Inzulza-Tapia A None Alarc ón M Source Type: research

Role of Non-Coding RNA of Human Platelet in Cardiovascular Disease
Curr Med Chem. 2021 Dec 30. doi: 10.2174/0929867329666211230104955. Online ahead of print.ABSTRACTCardiovascular diseases (CVD) are the major cause of death in the world. Numerous genetic studies involving transcriptomic approaches aimed at the detailed understanding of the disease and the development of new therapeutic strategies have been conducted over recent years. There has been an increase in research on platelets, which are implicated in CVD due to their capacity to release regulatory molecules that affect various pathways. Platelets secrete over 500 various kinds of molecules to plasma including large amounts of no...
Source: Current Medicinal Chemistry - December 30, 2021 Category: Chemistry Authors: None Inzulza-Tapia A None Alarc ón M Source Type: research

Role of Non-Coding RNA of Human Platelet in Cardiovascular Disease
Curr Med Chem. 2021 Dec 30. doi: 10.2174/0929867329666211230104955. Online ahead of print.ABSTRACTCardiovascular diseases (CVD) are the major cause of death in the world. Numerous genetic studies involving transcriptomic approaches aimed at the detailed understanding of the disease and the development of new therapeutic strategies have been conducted over recent years. There has been an increase in research on platelets, which are implicated in CVD due to their capacity to release regulatory molecules that affect various pathways. Platelets secrete over 500 various kinds of molecules to plasma including large amounts of no...
Source: Current Medicinal Chemistry - December 30, 2021 Category: Chemistry Authors: None Inzulza-Tapia A None Alarc ón M Source Type: research

Role of Non-Coding RNA of Human Platelet in Cardiovascular Disease
Curr Med Chem. 2021 Dec 30. doi: 10.2174/0929867329666211230104955. Online ahead of print.ABSTRACTCardiovascular diseases (CVD) are the major cause of death in the world. Numerous genetic studies involving transcriptomic approaches aimed at the detailed understanding of the disease and the development of new therapeutic strategies have been conducted over recent years. There has been an increase in research on platelets, which are implicated in CVD due to their capacity to release regulatory molecules that affect various pathways. Platelets secrete over 500 various kinds of molecules to plasma including large amounts of no...
Source: Current Medicinal Chemistry - December 30, 2021 Category: Chemistry Authors: None Inzulza-Tapia A None Alarc ón M Source Type: research

Epigenetic Modulators as Treatment Alternative to Diverse Types of Cancer
Curr Med Chem. 2021 Dec 28. doi: 10.2174/0929867329666211228111036. Online ahead of print.ABSTRACTDNA is packaged in rolls in an octamer of histones forming a complex of DNA and proteins called chromatin. Chromatin as a structural matrix of a chromosome and its modifications are nowadays considered relevant aspects for regulating gene expression, which has become of high interest in understanding genetic mechanisms regulating various diseases, including cancer. In various types of cancer, the main modifications are found to be DNA methylation in the CpG dinucleotide as a silencing mechanism in transcription, post-translati...
Source: Current Medicinal Chemistry - December 29, 2021 Category: Chemistry Authors: Jorseth Rodelo Guti érrez Arturo Ren é Mendoza Salgadoa Marcio De Ávila Arias Homero San- Juan- Vergara Wendy Rosales Rada Carlos Mario Mel éndez Gómez Source Type: research

Osteopontin in CardioMetabolic Medicine: a risk stratification biomarker with future therapeutic implication?
Curr Med Chem. 2021 Dec 28. doi: 10.2174/0929867329666211228113716. Online ahead of print.NO ABSTRACTPMID:34963431 | DOI:10.2174/0929867329666211228113716 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - December 29, 2021 Category: Chemistry Authors: Federico Montecucco Fabrizio Montecucco Source Type: research

Epigenetic Modulators as Treatment Alternative to Diverse Types of Cancer
Curr Med Chem. 2021 Dec 28. doi: 10.2174/0929867329666211228111036. Online ahead of print.ABSTRACTDNA is packaged in rolls in an octamer of histones forming a complex of DNA and proteins called chromatin. Chromatin as a structural matrix of a chromosome and its modifications are nowadays considered relevant aspects for regulating gene expression, which has become of high interest in understanding genetic mechanisms regulating various diseases, including cancer. In various types of cancer, the main modifications are found to be DNA methylation in the CpG dinucleotide as a silencing mechanism in transcription, post-translati...
Source: Current Medicinal Chemistry - December 29, 2021 Category: Chemistry Authors: Jorseth Rodelo Guti érrez Arturo Ren é Mendoza Salgadoa Marcio De Ávila Arias Homero San- Juan- Vergara Wendy Rosales Rada Carlos Mario Mel éndez Gómez Source Type: research

Osteopontin in CardioMetabolic Medicine: a risk stratification biomarker with future therapeutic implication?
Curr Med Chem. 2021 Dec 28. doi: 10.2174/0929867329666211228113716. Online ahead of print.NO ABSTRACTPMID:34963431 | DOI:10.2174/0929867329666211228113716 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - December 29, 2021 Category: Chemistry Authors: Federico Montecucco Fabrizio Montecucco Source Type: research

The significant role of nutraceutical compounds in ulcerative colitis treatment
Curr Med Chem. 2021 Dec 27. doi: 10.2174/0929867329666211227121321. Online ahead of print.ABSTRACTUlcerative colitis (UC) is a type of inflammatory bowel disease (IBD) mainly affecting the colon and the rectum. Its main characters are represented by relapsing and remitting mucosal inflammation, starting in the rectum and typically extending continuously proximally through part or the entire colon. UC pathogenesis depends on multiple factors, such as genetic predisposition, defects in the epithelial barrier, dysregulated immune responses, and environmental causes. The most frequent symptoms are abdominal pain, weight loss, ...
Source: Current Medicinal Chemistry - December 28, 2021 Category: Chemistry Authors: Azzurra Chiara De Maio Giovanna Basile Domenico Iacopetta Alessia Catalano Jessica Ceramella Danilo Cafaro Carmela Saturnino Maria Stefania Sinicropi Source Type: research

Targeting Cellular Signalling Pathways in Cancer by Natural Compounds
Curr Med Chem. 2021;28(39):7986-7987. doi: 10.2174/092986732839211221230307.NO ABSTRACTPMID:34961437 | DOI:10.2174/092986732839211221230307 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - December 28, 2021 Category: Chemistry Authors: Md Asaduzzaman Khan Mohammad Amjad Kamal Source Type: research

New Insights into the Biosensing of Parkinson's Disease Biomarkers: A Concise Review
CONCLUSION: The development of novel biosensors is required for the early diagnosis of PD as sensitive, rapid, reliable, and cost-effective systems.PMID:34961452 | DOI:10.2174/0929867328666211213111812 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - December 28, 2021 Category: Chemistry Authors: Elaheh Sadat Hosseini Soheila Mohammadi Reza Khodarahmi Mohamad Hassan Fouani Omid Tavallaei Khojaste Rahimi Jaberi Zahra Shabaninejad Sajjad Janfaza Rezvan Yazdian-Robati Soraya Sajadimajd Source Type: research

Gut Microbiota and Cardiovascular Disease: Symbiosis Versus Dysbiosis
Curr Med Chem. 2021 Dec 12. doi: 10.2174/0929867328666211213112949. Online ahead of print.ABSTRACTThe gut microbiome interacts with host physiology through various mechanisms, including the cardiovascular (CV) system. A healthy microbiome has the ability to process and digest complex carbohydrates into short-chain fatty acids (SCFA). These SCFA function as signaling molecules, immune-modulating molecules, and energy sources. However, when the microbiome is altered, it produces gut dysbiosis with overgrowth of certain bacteria that may lead to overproduction of trimethylamine-N-oxide (TMAO) from the metabolism of phosphatid...
Source: Current Medicinal Chemistry - December 28, 2021 Category: Chemistry Authors: Antonis A Manolis Theodora A Manolis Helen Melita Antonis S Manolis Source Type: research

Regulation of homeostasis by neuropeptide Y: involvement in food intake
Curr Med Chem. 2021 Dec 12. doi: 10.2174/0929867328666211213114711. Online ahead of print.ABSTRACTObesity leads to several metabolic disorders and, unfortunately, current pharmacological treatments for obesity are not very effective. In feeding mechanisms, the hypothalamus and some neuropeptides play an important role. Many data show that neuropeptide Y (NPY) is involved in these mechanisms. The aim of this review is to update the physiological actions mediated by the orexigenic peptide NPY, via its receptors, in the control of food intake and to review its involvement in food intake disorders. The relationships between NP...
Source: Current Medicinal Chemistry - December 28, 2021 Category: Chemistry Authors: Pilar Marcos Rabal Rafael Cove ñas Source Type: research

2D Materials-Based Aptamer Biosensors: Present Status and Way Forward
Curr Med Chem. 2021 Dec 12. doi: 10.2174/0929867328666211213115723. Online ahead of print.ABSTRACTCurrent advances in constructing functional nanomaterials and elegantly designed nanostructures have opened up new possibilities for the fabrication of viable field biosensors. Two-dimensional materials (2DMs) have fascinated much attention due to their chemical, optical, physicochemical, and electronic properties. They are ultrathin nanomaterials with unique properties such as high surface-to-volume ratio, surface charge, shape, high anisotropy, and adjustable chemical functionality. 2DMs such as graphene-based 2D materials, ...
Source: Current Medicinal Chemistry - December 28, 2021 Category: Chemistry Authors: Raj Kumar Sen Priyanka Prabhakar Neha Bisht Monika Patel Shruti Mishra Amit Kumar Yadav Divya Vadakkumana Venu Gaurav Kumar Gupta Pratima R Solanki Seeram Ramakrishnan Dehipada Mondal Avanish Kumar Srivastava Neeraj Dwivedi Chetna Dhand Source Type: research

Costimulation Blockade Resistant Rejection
Curr Med Chem. 2021 Dec 13. doi: 10.2174/0929867328666211213153859. Online ahead of print.NO ABSTRACTPMID:34961456 | DOI:10.2174/0929867328666211213153859 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - December 28, 2021 Category: Chemistry Authors: Dimitrios Moris Source Type: research

The Emerging Role of Epigenetic Methylation in Kidney Disease
Curr Med Chem. 2021 Dec 12. doi: 10.2174/1573405617666211213110222. Online ahead of print.ABSTRACTKidney disease has complex and multifactorial pathophysiology and pathogenesis. Recent studies have revealed that epigenetic methylation changes, namely DNA methylation, histone methylation and non-histone methylation, are strongly implicated in various forms of kidney diseases. This review provides a perspective on the emerging role of epigenetic methylation in kidney disease, including the effects of DNA methylation in diverse promoter regions, regulation and implication of histone methylation, and recent advances and potent...
Source: Current Medicinal Chemistry - December 28, 2021 Category: Chemistry Authors: Li Wen Hong-Liu Yang Lin Lin Liang Ma Ping Fu Source Type: research