EACVP: An ESM-2 LM Framework Combined CNN and CBAM Attention to Predict Anti-coronavirus Peptides
CONCLUSION: The results prove that this model EACVP could fully characterize the peptide information and achieve high prediction accuracy. It can be generalized to different data sets. The data and code of the article have been uploaded to https://github.- com/JYY625/EACVP.git.PMID:38494930 | DOI:10.2174/0109298673287899240303164403 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - March 18, 2024 Category: Chemistry Authors: Shengli Zhang Yuanyuan Jing Yunyun Liang Source Type: research
We Must Abandon the Myth: Oxidized Low-density Lipoprotein is not a Lipoprotein that Plays a Key Role in Atherogenesis
Curr Med Chem. 2024 Mar 15. doi: 10.2174/0109298673301236240311113807. Online ahead of print.ABSTRACTThe purpose of this review is to revisit in detail the arguments supporting or disproving the hypothesis that oxidized low-density lipoprotein (LDL) plays a key role in atherosclerotic lesion development. The detection of oxidized LDL in vivo was extremely important for confirming its key role in atherogenesis. Indirect evidence of its existence included the presence of autoantibodies against malondialdehyde-treated LDL in human blood; however, the affinity of circulating antibodies to another LDL modification, such as desi...
Source: Current Medicinal Chemistry - March 18, 2024 Category: Chemistry Authors: Alexander N Orekhov Source Type: research
Therapeutic Potential of Traditional Oriental Medicines in Targeting Tau Pathology: Insights from Cell-free and Cell-based Screening
CONCLUSION: Our results suggest that five TOMs are potential therapeutic candidates for tau pathology. In particular, Hwanglyeonhaedoktang showed the greatest efficacy among the five TOMs in cell-free and cell-based screening approaches. These findings suggest that Hwanglyeonhaedoktang is suitable for treating AD patients with tau pathology.PMID:38486385 | DOI:10.2174/0109298673295901240311072440 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - March 15, 2024 Category: Chemistry Authors: Hyun Ha Park Byeong-Hyeon Kim Seol Hwa Leem Yong Ho Park Hyunju Chung Doo-Han Yoo Insu Park Yunkwon Nam Sujin Kim Soo Jung Shin Minho Moon Source Type: research
Therapeutic Potential of Traditional Oriental Medicines in Targeting Tau Pathology: Insights from Cell-free and Cell-based Screening
CONCLUSION: Our results suggest that five TOMs are potential therapeutic candidates for tau pathology. In particular, Hwanglyeonhaedoktang showed the greatest efficacy among the five TOMs in cell-free and cell-based screening approaches. These findings suggest that Hwanglyeonhaedoktang is suitable for treating AD patients with tau pathology.PMID:38486385 | DOI:10.2174/0109298673295901240311072440 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - March 15, 2024 Category: Chemistry Authors: Hyun Ha Park Byeong-Hyeon Kim Seol Hwa Leem Yong Ho Park Hyunju Chung Doo-Han Yoo Insu Park Yunkwon Nam Sujin Kim Soo Jung Shin Minho Moon Source Type: research
Therapeutic Potential of Traditional Oriental Medicines in Targeting Tau Pathology: Insights from Cell-free and Cell-based Screening
CONCLUSION: Our results suggest that five TOMs are potential therapeutic candidates for tau pathology. In particular, Hwanglyeonhaedoktang showed the greatest efficacy among the five TOMs in cell-free and cell-based screening approaches. These findings suggest that Hwanglyeonhaedoktang is suitable for treating AD patients with tau pathology.PMID:38486385 | DOI:10.2174/0109298673295901240311072440 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - March 15, 2024 Category: Chemistry Authors: Hyun Ha Park Byeong-Hyeon Kim Seol Hwa Leem Yong Ho Park Hyunju Chung Doo-Han Yoo Insu Park Yunkwon Nam Sujin Kim Soo Jung Shin Minho Moon Source Type: research
Discovery of Multiple Effects of Reactive Oxygen Species on Lung Adenocarcinoma at the Single-cell and Bulk Tissue Levels
CONCLUSION: The current study provided novel insights into the impact of ROS on LUAD pathology at both single-cell and bulk-tissue levels, facilitating the prognostic evaluation and drug therapy development for patients with LUAD.PMID:38485675 | DOI:10.2174/0109298673291009240219055808 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - March 14, 2024 Category: Chemistry Authors: Cong Zhang Bin Liu Xianjin Xie Degan Lu Source Type: research
3D Bioprinting and Microfluidic-Based Devices for Cancer Detection and Drug Treatment: Focus on Prostate Cancer
Curr Med Chem. 2024 Mar 8. doi: 10.2174/0109298673298382240307040239. Online ahead of print.ABSTRACTThe burden of increasing cancer incidence among the population, and, in particular, of prostate cancer in men living in highly developed countries, brings with it, on one hand, the need for new devices that allow a faster and earlier diagnosis, ideally in a non-invasive way and with low consumption of expensive reagents, and on the other the need for the assessment of new in vitro models that allow a more reliable assessment of cancer features, including its microenvironment and sensibility to different drugs. At the crossro...
Source: Current Medicinal Chemistry - March 12, 2024 Category: Chemistry Authors: Jay Sibbits Lucia Di Pietro Anna Privitera Vincenzo Cardaci Salvatore Maugeri Massimo Camarda Giuseppe Caruso Source Type: research
Regulating Triplet Excitons of Organic Luminophores for Promoted Bioimaging
Curr Med Chem. 2024 Mar 11. doi: 10.2174/0109298673301552240305064259. Online ahead of print.ABSTRACTAfterglow materials with organic room temperature phosphorescence (RTP) or thermally activated delayed fluorescence (TADF) exhibit significant potential in biological imaging due to their long lifetime. By utilizing time-resolved technology, interference from biological tissue fluorescence can be mitigated, enabling high signal-- to-background ratio imaging. Despite the continued emergence of individual reports on RTP or TADF in recent years, comprehensive reviews addressing these two materials are rare. Therefore, this rev...
Source: Current Medicinal Chemistry - March 12, 2024 Category: Chemistry Authors: Zhipeng Zhao Rui Du Xiaodi Feng Zhengshuo Wang Tianjie Wang Zongzhao Xie Hua Yuan Yeqiang Tan Hanlin Ou Source Type: research
SGPocket: A New Graph Convolutional Neural Network for Ligand-protein Binding Site Prediction
CONCLUSION: Thus, SGPocket allows the reduction of the exploration surface in the molecular docking process by restricting the simulation only to the site(s) predicted to be interesting.PMID:38468517 | DOI:10.2174/0109298673289137240304165758 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - March 12, 2024 Category: Chemistry Authors: Kevin Crampon Cedric Bourrasset Stephanie Baud Luiz Angelo Steffenel Source Type: research
3D Bioprinting and Microfluidic-Based Devices for Cancer Detection and Drug Treatment: Focus on Prostate Cancer
Curr Med Chem. 2024 Mar 8. doi: 10.2174/0109298673298382240307040239. Online ahead of print.ABSTRACTThe burden of increasing cancer incidence among the population, and, in particular, of prostate cancer in men living in highly developed countries, brings with it, on one hand, the need for new devices that allow a faster and earlier diagnosis, ideally in a non-invasive way and with low consumption of expensive reagents, and on the other the need for the assessment of new in vitro models that allow a more reliable assessment of cancer features, including its microenvironment and sensibility to different drugs. At the crossro...
Source: Current Medicinal Chemistry - March 12, 2024 Category: Chemistry Authors: Jay Sibbits Lucia Di Pietro Anna Privitera Vincenzo Cardaci Salvatore Maugeri Massimo Camarda Giuseppe Caruso Source Type: research
Regulating Triplet Excitons of Organic Luminophores for Promoted Bioimaging
Curr Med Chem. 2024 Mar 11. doi: 10.2174/0109298673301552240305064259. Online ahead of print.ABSTRACTAfterglow materials with organic room temperature phosphorescence (RTP) or thermally activated delayed fluorescence (TADF) exhibit significant potential in biological imaging due to their long lifetime. By utilizing time-resolved technology, interference from biological tissue fluorescence can be mitigated, enabling high signal-- to-background ratio imaging. Despite the continued emergence of individual reports on RTP or TADF in recent years, comprehensive reviews addressing these two materials are rare. Therefore, this rev...
Source: Current Medicinal Chemistry - March 12, 2024 Category: Chemistry Authors: Zhipeng Zhao Rui Du Xiaodi Feng Zhengshuo Wang Tianjie Wang Zongzhao Xie Hua Yuan Yeqiang Tan Hanlin Ou Source Type: research
SGPocket: A New Graph Convolutional Neural Network for Ligand-protein Binding Site Prediction
CONCLUSION: Thus, SGPocket allows the reduction of the exploration surface in the molecular docking process by restricting the simulation only to the site(s) predicted to be interesting.PMID:38468517 | DOI:10.2174/0109298673289137240304165758 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - March 12, 2024 Category: Chemistry Authors: Kevin Crampon Cedric Bourrasset Stephanie Baud Luiz Angelo Steffenel Source Type: research
3D Bioprinting and Microfluidic-Based Devices for Cancer Detection and Drug Treatment: Focus on Prostate Cancer
Curr Med Chem. 2024 Mar 8. doi: 10.2174/0109298673298382240307040239. Online ahead of print.ABSTRACTThe burden of increasing cancer incidence among the population, and, in particular, of prostate cancer in men living in highly developed countries, brings with it, on one hand, the need for new devices that allow a faster and earlier diagnosis, ideally in a non-invasive way and with low consumption of expensive reagents, and on the other the need for the assessment of new in vitro models that allow a more reliable assessment of cancer features, including its microenvironment and sensibility to different drugs. At the crossro...
Source: Current Medicinal Chemistry - March 12, 2024 Category: Chemistry Authors: Jay Sibbits Lucia Di Pietro Anna Privitera Vincenzo Cardaci Salvatore Maugeri Massimo Camarda Giuseppe Caruso Source Type: research
Regulating Triplet Excitons of Organic Luminophores for Promoted Bioimaging
Curr Med Chem. 2024 Mar 11. doi: 10.2174/0109298673301552240305064259. Online ahead of print.ABSTRACTAfterglow materials with organic room temperature phosphorescence (RTP) or thermally activated delayed fluorescence (TADF) exhibit significant potential in biological imaging due to their long lifetime. By utilizing time-resolved technology, interference from biological tissue fluorescence can be mitigated, enabling high signal-- to-background ratio imaging. Despite the continued emergence of individual reports on RTP or TADF in recent years, comprehensive reviews addressing these two materials are rare. Therefore, this rev...
Source: Current Medicinal Chemistry - March 12, 2024 Category: Chemistry Authors: Zhipeng Zhao Rui Du Xiaodi Feng Zhengshuo Wang Tianjie Wang Zongzhao Xie Hua Yuan Yeqiang Tan Hanlin Ou Source Type: research
SGPocket: A New Graph Convolutional Neural Network for Ligand-protein Binding Site Prediction
CONCLUSION: Thus, SGPocket allows the reduction of the exploration surface in the molecular docking process by restricting the simulation only to the site(s) predicted to be interesting.PMID:38468517 | DOI:10.2174/0109298673289137240304165758 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - March 12, 2024 Category: Chemistry Authors: Kevin Crampon Cedric Bourrasset Stephanie Baud Luiz Angelo Steffenel Source Type: research