Drug Design and Development for Neglected Diseases.
Abstract PMID: 31618168 [PubMed - in process] (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - October 18, 2019 Category: Chemistry Authors: Ferreira EI Tags: Curr Med Chem Source Type: research

Special Issue on New Cellular, Genetic and Proteomic Tools in the Prevention and Management of Diabetes Mellitus.
Abstract PMID: 31612806 [PubMed - in process] (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - October 17, 2019 Category: Chemistry Authors: Rosado JA, Redondo Liberal PC Tags: Curr Med Chem Source Type: research

Managing Side Effects on Ocular Surface Caused by Glaucoma Eye Drops.
Abstract PMID: 31612807 [PubMed - in process] (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - October 17, 2019 Category: Chemistry Authors: Ferreras A, Figus M, Fogagnolo P, Iester M, Frezzotti P Tags: Curr Med Chem Source Type: research

Advances in pharmacological activities and mechanisms of glycyrrhizic acid.
This article gives an overview of the pharmacological activities and mechanisms of licorice metabolites and the adverse reactions that need attention. This review helps to further investigate the possibility of licorice as a potential drug for various diseases. It is hoped that this review can provide relevant theoretical basis for relevant scholars' research and their own learning. PMID: 31612817 [PubMed - as supplied by publisher] (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - October 11, 2019 Category: Chemistry Authors: Chen K, Yang R, Shen F, Zhu HL Tags: Curr Med Chem Source Type: research

Targeting inflammatory mediators: An anticancer mechanism of thymoquinone action.
CONCLUSION: This article reviewed the role of inflammation on cancer development, and the action of thymoquinone on inflammatory molecules, which have been proved in vitro and in vivo. Much more attention is required for studying the immunotherapeutic role of thymoquinone and developing this molecule as future immunotherapeutic drug. PMID: 31604405 [PubMed - as supplied by publisher] (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - October 11, 2019 Category: Chemistry Authors: Akter Z, Ahmed FR, Tania M, Khan MA Tags: Curr Med Chem Source Type: research

Diabetic Theory in Anti-Alzheimer's Drug Research and Development. Part 1: Therapeutic Potential of Antidiabetic Agents.
Abstract Alzheimer's disease (AD) is a chronic and progressive neurodegenerative disorder that affects over 46 million people worldwide. It is characterized by a decline in cognitive abilities, including memory and thinking skills. AD patients also suffer from behavioral and psychological symptoms of dementia of which depression is the most prevalent. Currently available drugs provide modest symptomatic relief and do not reduce pathological hallmarks (senile plaques and neurofibrillary tangles) and neuroinflammation, both of which are integral parts of AD. Studies suggest that AD is a type of diabetes manifested i...
Source: Current Medicinal Chemistry - October 11, 2019 Category: Chemistry Authors: Jankowska A, Wesołowska A, Pawłowski M, Rzepa GC Tags: Curr Med Chem Source Type: research

Encapsulation of plant-derived bioactive ingredients through electrospraying for nutraceuticals and functional foods applications.
bio A Abstract The electrospraying technique, which consists of electrohydrodynamic atomization of polymeric fluids, can be used to generate dry nano- and microparticles by subjecting a polymer solution, suspension or melt to a high voltage (typically in the range of 7-20 kV) electric field. This potential can be exploited for developing nano- and microencapsulation structures under mild temperature conditions and, thus, constitutes a promising alternative to conventional microencapsulation techniques for sensitive ingredients, like most plant-derived bioactive compounds, especially for their application in the fo...
Source: Current Medicinal Chemistry - October 10, 2019 Category: Chemistry Authors: Gómez-Mascaraque LG, Lopez-Rubio A Tags: Curr Med Chem Source Type: research

Targeting bacterial antioxidant systems for antibiotics development.
Abstract The emergence of multidrug-resistant bacteria has become an urgent issue in modern medicine which requires novel strategies to develop antibiotics. Recent studies have supported the hypothesis that antibiotic-induced bacterial cell death is mediated by reactive oxygen species (ROS). The hypothesis also highlighted the importance of antioxidant systems the defense mechanism which contribute to antibiotic resistance. Thioredoxin and glutathione systems are the two major thiol-dependent systems not only provide antioxidant capacity but also participate in various biological events in bacteria, such as DNA sy...
Source: Current Medicinal Chemistry - October 7, 2019 Category: Chemistry Authors: Ren X, Zou L, Holmgren A Tags: Curr Med Chem Source Type: research

Recent In Silico Resources for Drug Design and Discovery.
Abstract PMID: 31584358 [PubMed - in process] (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - October 5, 2019 Category: Chemistry Authors: Veljkovic N Tags: Curr Med Chem Source Type: research

Organic Molecule Based Chemosensors for Biomedical Application.
Abstract PMID: 31584359 [PubMed - in process] (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - October 5, 2019 Category: Chemistry Authors: Ding Y Tags: Curr Med Chem Source Type: research

Stem Cell Transplant for Advanced Stage Liver Disorders: Current Scenario and Future Prospects.
CONCLUSION: The SC-based interventions provide significant improvement in patients with CLD, however, there is a need of randomized, controlled studies with analysis of long-term follow-up. PMID: 31584360 [PubMed - as supplied by publisher] (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - October 4, 2019 Category: Chemistry Authors: Mahmood A, Seetharaman R, Kshatriya P, Patel D, Srivastava AS Tags: Curr Med Chem Source Type: research

Insights into Design of p97-targeting Small Molecules from Structural Studies on p97 Functional Mechanism.
Abstract p97, also known as valosin-containing protein or CDC48, is a member of the AAA+ protein family that is highly conserved in eukaryotes. It binds to various cofactors in the body to perform its protein-unfolding function and participates in DNA repair, degradation of subcellular membrane proteins, and protein quality control pathways, among other processes. Its malfunction can lead to many diseases, such as inclusion body myopathy, associated with Paget's disease of bone and/or frontotemporal dementia, amyotrophic lateral sclerosis disease, and others. In recent years, many small molecule inhibitors have be...
Source: Current Medicinal Chemistry - October 4, 2019 Category: Chemistry Authors: Sui X, Pan M, Li YM Tags: Curr Med Chem Source Type: research

Molecular markers of regulatory T cells and their importance in anticancer chemotherapy - A comprehensive review.
Abstract Immunological principles based on Treg cell self-stabilization and the discovery that tumors are capable of evading the body's defense mechanism have led to more effective immuno-oncology therapies. Hence, next generation immunotherapy can only be effective if researchers have an in-depth understanding of the function and regulation of Treg cells in antitumor immunity combined with the discovery of new immunity targets. This can enhance clinical efficacy of future and novel therapies and reduces any adverse reactions arising from the latter. This review of the literature discusses tumor treatment strategi...
Source: Current Medicinal Chemistry - October 4, 2019 Category: Chemistry Authors: Kaboli PJ, Zhang L, Xiang S, Shen J, Li M, Zhao Y, Wu X, Zhao Q, Zhang H, Lin L, Yin J, Wu Y, Wan L, Yi T, Li X, Cho CH, Li J, Xiao Z, Wen Q Tags: Curr Med Chem Source Type: research

Tubulin inhibitors binding to colchicine-site: A Review from 2015 to 2019.
Abstract Based on three domains of colchicine-site which is conducive to the combination with small molecular compounds, colchicine-site on the tubulin has become a popular target for antitumor, that resulted in a great number of tubulin inhibitors binding to colchicine-site were reported and evaluated over the past years. Here, tubulin inhibitors targeting colchicine-site and their application to antitumor were reviewed from 2015 to 2019. Tubulin inhibitors were classified to ten categories according to structural features, as colchicine derivates, CA-4 analogues, chalcone analogues, coumarin analogs, indole hybr...
Source: Current Medicinal Chemistry - October 3, 2019 Category: Chemistry Authors: Xia LY, Zhang YL, Yang R, Wang ZC, Lu YD, Wang BZ, Zhu HL Tags: Curr Med Chem Source Type: research

Epigenetic marks in Polycystic Ovary Syndrome.
Abstract Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder that affects women in their reproductive age. Recent studies have shown that genes have an important role in the etiology of PCOS. However, the precise way in which these genes are transcriptionally and post-transcriptionally regulated is poorly understood. The aim of the present review is to provide updated information on miRNAs and DNA methylation as epigenetic marks of PCOS. The data presented here allow concluding that both microRNAs and DNA methylation can be considered as possible useful biomarkers when choosing the treatm...
Source: Current Medicinal Chemistry - October 3, 2019 Category: Chemistry Authors: Motta AB Tags: Curr Med Chem Source Type: research

Fluorine-Containing Inhalation Anesthetics: Chemistry, Properties, and Pharmacologies.
Abstract The stories of fluorinated inhalation anesthetics, including synthesis, physicochemistry and pharmacologies, were summarized in this review. Retrospecting the history of inhalation anesthetics revealed their increasing reliance on fluorine and ether structures. Halothane causes a rare but severe immune-based hepatotoxicity, which was resplaced by enflurane in the 1970s. Isoflurane took the place of enflurane in the 1980s, showing modest advantages (e.g., lower solubility, better metabolic stability, and without convulsive predisposition). Desflurane and sevoflurane came into use in the 1990s, which are be...
Source: Current Medicinal Chemistry - October 3, 2019 Category: Chemistry Authors: Wang Y, Ming XX, Zhang CP Tags: Curr Med Chem Source Type: research

Medicinal Diets: From Molecules to Nutrients to Foods: Basic and Clinical Implications.
Abstract PMID: 31564245 [PubMed - in process] (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - October 2, 2019 Category: Chemistry Authors: Portincasa P, De Angelis M, Lammert F, Stokes CS Tags: Curr Med Chem Source Type: research

Therapeutic Aptamers: Evolving to Find Their Clinical Niche.
CONCLUSION: In this manuscript, we hope the reader appreciates that the success of aptamers becoming a class of drugs is less about nucleic acid biochemistry and more about target validation and overall drug chemistry. PMID: 31573879 [PubMed - as supplied by publisher] (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - October 1, 2019 Category: Chemistry Authors: Nimjee SM, Sullenger BA Tags: Curr Med Chem Source Type: research

Discovery and Development of the Oral Complement Factor D Inhibitor ACH-4471.
CONCLUSION: ACH-4471 is well tolerated and demonstrates meaningful improvement in clinical efficacy endpoints for the treatment of PNH. Because CFD is not required for activation of either the CP or LP, selective CFD inhibition by ACH-4471 presents a favorable therapeutic approach to modulating complement activity that leaves intact the effector functions following CP and LP activation and thus poses a lower risk of bacterial infection than other complement-directed approaches. PMID: 31573880 [PubMed - as supplied by publisher] (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - October 1, 2019 Category: Chemistry Authors: Wiles JA, Galvan MD, Podos SD, Geffner M, Huang M Tags: Curr Med Chem Source Type: research

Mercury exposure, epigenetic alterations, and brain tumorigenesis: A possible relationship?
eth J Abstract The risk assessment of mercury (Hg), in both wildlife and humans, represents an increasing challenge. Increased production of reactive oxygen species (ROS) is a known Hg-induced toxic effect, which can be accentuated by other environmental pollutants and by complex interactions between environmental and genetic factors. Some epidemiological and experimental studies have investigated a possible correlation between brain tumors and heavy metals. Epigenetic modifications in brain tumors include aberrant activation of genes, hypomethylation of specific genes, changes in various histones, and CpG hyperme...
Source: Current Medicinal Chemistry - September 30, 2019 Category: Chemistry Authors: Bjørklund G, Pivina L, Dadar M, Semenova Y, Chirumbolo S, Aaseth J Tags: Curr Med Chem Source Type: research

Aging Brain: In Search of Better Neurotherapeutics.
Abstract PMID: 31553282 [PubMed - in process] (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - September 27, 2019 Category: Chemistry Authors: Bagetta G, Scuteri D Tags: Curr Med Chem Source Type: research

Endothelium in aortic aneurysm disease: New insights.
Abstract Inflammation is recognized as a fundamental element in the development and growth of aortic aneurysms. Aortic aneurysm is correlated with aortic wall deformities and injury, as a result of inflammation, matrix metalloproteinases activation, oxidative stress, and apoptosis of vascular smooth muscle cells. Endothelial wall has a critical part in the inflammation of the aorta and endothelial heterogeneity has proven to be significant for modeling aneurysm formation. Endothelial shear stress and blood flow affects the aortic wall through hindrance of cytokines and adhesion molecules excreted by endothelial ce...
Source: Current Medicinal Chemistry - September 23, 2019 Category: Chemistry Authors: Spartalis E, Spartalis M, Athanasiou A, Paschou SA, Patelis N, Voudris V, Iliopoulos DC Tags: Curr Med Chem Source Type: research

Novel Therapeutic Strategies for the Treatment of Chronic Diseases.
Abstract PMID: 31526336 [PubMed - in process] (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - September 20, 2019 Category: Chemistry Authors: Testa G, Passaro F, Cinquegrana A, Palma M, Abete P, Tocchetti CG Tags: Curr Med Chem Source Type: research

G-quadruplex - Characterization of Functions and Potential Therapeutic Uses of Non-canonical DNA Structures.
Abstract PMID: 31526337 [PubMed - in process] (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - September 20, 2019 Category: Chemistry Authors: Prosperi M Tags: Curr Med Chem Source Type: research

Enzyme Inhibitors as the Attractive Targets for the Treatment of Various Diseases.
Abstract PMID: 31526340 [PubMed - in process] (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - September 20, 2019 Category: Chemistry Authors: Orhan IE Tags: Curr Med Chem Source Type: research

Cancer Immunotherapy and Immunomodulation.
Abstract PMID: 31526344 [PubMed - in process] (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - September 20, 2019 Category: Chemistry Authors: Wang G Tags: Curr Med Chem Source Type: research

Treatment of Ciliopathies: Current Perspectives.
Abstract PMID: 31526345 [PubMed - in process] (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - September 20, 2019 Category: Chemistry Authors: Gerhardt C Tags: Curr Med Chem Source Type: research

Commentary on "Current Challenges in the Development of Vaccines and Drugs Against Emerging Vector-borne Diseases" by Professor Kwang-sun Kim, Pusan National University, Republic of Korea.
Commentary on "Current Challenges in the Development of Vaccines and Drugs Against Emerging Vector-borne Diseases" by Professor Kwang-sun Kim, Pusan National University, Republic of Korea. Curr Med Chem. 2019;26(17):3201-3204 Authors: Honek JF Abstract PMID: 31526346 [PubMed - in process] (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - September 20, 2019 Category: Chemistry Authors: Honek JF Tags: Curr Med Chem Source Type: research

Neuromedin U and Structural Analogs: an Overview of Their Structure, Function and Selectivity.
let S Abstract The neuromedin U peptide sequence is highly conserved between various species. Neuromedin U is involved in a variety of physiological processes. It exerts its effects via two neuromedin U receptors, NMUR1 and NMUR2. These receptors are characterized by a distinct, yet complementary, tissue distribution with NMUR1 mostly found in the periphery, while NMUR2 is most abundant in the central nervous system. The capability of the neuropeptide to reduce food intake in rodents triggered the design and synthesis of broad range of modified peptide ligands. The purpose of these ligands is to develop novel ther...
Source: Current Medicinal Chemistry - September 16, 2019 Category: Chemistry Authors: De Prins A, Van Eeckhaut A, Smolders I, Tourwé D, Ballet S Tags: Curr Med Chem Source Type: research

Bioactive secondary metabolites from endophytic fungi.
CONCLUSION: Endophytes represent an inexhaustible reservoir of pharmacologically important compounds. Moreover, endophytic fungi could be exploited for sustainable production of bioactive "plant metabolites" in the future. Towards this aim, further insights into the dynamic endophyte - host plant interactions and origin of endophytic fungal genes would be of utmost importance. PMID: 31526342 [PubMed - as supplied by publisher] (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - September 16, 2019 Category: Chemistry Authors: Ancheeva E, Daletos G, Proksch P Tags: Curr Med Chem Source Type: research

Biomimetic nanostructures with compositional gradient grown by combinatorial matrix-assisted pulsed laser evaporation for tissue engineering.
Abstract There is permanent progress with the fabrication of smart bioactive surfaces that could govern tissue regeneration. Thin coatings of two or more materials with compositional gradient allow the construction of arrays with different chemical and physical features on a solid substrate. With such intelligent bio-platforms, cells can be exposed to a tissue-like biomimetic micro-environment with precise characteristics that directs cells fate towards specific phenotypes. We have introduced combinatorial matrix-assisted pulsed laser evaporation (C-MAPLE) as an alternative approach for the fabrication in a single...
Source: Current Medicinal Chemistry - September 16, 2019 Category: Chemistry Authors: Sima F, Axente E Tags: Curr Med Chem Source Type: research

The Molecular Oncology of Drug Resistance: Targets, Drugs and Chemical Biology.
PMID: 31518215 [PubMed - as supplied by publisher] (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - September 13, 2019 Category: Chemistry Authors: Beretta GL Tags: Curr Med Chem Source Type: research

Computational Analysis of Dipyrone Metabolite 4-Aminoantipyrine as a Cannabinoid Receptor 1 Agonist.
CONCLUSION: Analysis of the complex of 4-aminoantipyrine and Cannabinoid Receptor 1 revealed the pivotal role played by residues Phe 170, Phe 174, Phe 177, Phe 189, Leu 193, Val 196, and Phe 379, besides the conserved hydrogen bond at Ser 383. The mechanistic analysis and the present computational study suggest that the dipyrone metabolite 4-aminoantipyrine interacts with Cannabinoid Receptor 1. PMID: 31490743 [PubMed - as supplied by publisher] (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - September 6, 2019 Category: Chemistry Authors: Russo S, de Azevedo WF Tags: Curr Med Chem Source Type: research

Targeting the endothelial Ca 2+ tool kit to rescue endothelial dysfunction in obesity associated-hypertension.
CONCLUSION: The endothelial Ca 2+ toolkit could be targeted to reduce vascular damage and rescue endothelium-dependent vasodilation in obese vessels. This hypothesis remains, however, to be probed on truly obese endothelial cells. PMID: 31486745 [PubMed - as supplied by publisher] (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - September 5, 2019 Category: Chemistry Authors: Moccia F, Negri S, Faris P, Berra-Romani R Tags: Curr Med Chem Source Type: research

Trojan Microparticles Potential for Ophthalmic Drug Delivery.
The objective of the present review is to show the state of art concerning the design, preparation and characterization of trojan microparticles for drug delivery and to remark their potential and limitations as IODDS, one of the most important challenge faced by pharmaceutical technology at the moment. PMID: 31486746 [PubMed - as supplied by publisher] (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - September 5, 2019 Category: Chemistry Authors: Bravo-Osuna I, Perez SE, Guerrero VA, Martínez ITM, Vanrell RH Tags: Curr Med Chem Source Type: research

Electrochemical and Optical Biosensing Strategies for DNA Methylation Analysis.
This article reviewed the development of electrochemistry and optical biosensing analysis of DNA methylation in recent years, in addition, we also reviewed some recent advances in the detection of DNA methylation using new techniques, such as nanopore biosensors, and highlighted the key technical and biological challenges involved in these methods. We hope this paper will provide useful information for the selection and establishment of analysis of DNA methylation. PMID: 31480993 [PubMed - as supplied by publisher] (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - September 3, 2019 Category: Chemistry Authors: Zhang S, Huang J, Lu JR, Liu M, Chen X, Su SS, Mo F, Zheng JS Tags: Curr Med Chem Source Type: research

A review of drug repositioning based chemical-induced cell line expression data.
Abstract Drug repositioning is an important area of biomedical research. The drug repositioning studies have shifted to computational approaches. Large-scale perturbation databases, such as the Connectivity Map and the Library of Integrated Network-Based Cellular Signatures, contain a number of chemical-induced gene expression profiles and provide great opportunities for computational biology and drug repositioning. One reason is that the profiles provided by the Connectivity Map and the Library of Integrated Network-Based Cellular Signatures databases show an overall view of biological mechanism in drugs, disease...
Source: Current Medicinal Chemistry - September 3, 2019 Category: Chemistry Authors: Wang F, Lei X, Wu FX Tags: Curr Med Chem Source Type: research

Endothelial dysfunction in dyslipidaemia: Molecular mechanisms and clinical implications.
Abstract The endothelium consists of a monolayer of endothelial cells (ECs) which form the inner cellular lining of veins, arteries, capillaries and lymphatic vessels. ECs interact with the blood and lymph. The endothelium fulfils functions such as vasodilatation, regulation of adhesion, infiltration of leukocytes, inhibition of platelet adhesion, vessel remodeling and lipoprotein metabolism. ECs synthesize and release compounds such as nitric oxide (NO), metabolites of arachidonic acid, reactive oxygen species (ROS) and enzymes that degrade the extracellular matrix. Endothelial dysfunction represents a phenotype ...
Source: Current Medicinal Chemistry - September 3, 2019 Category: Chemistry Authors: Zaric B, Obradovic M, Trpkovic A, Banach M, Mikhailidis DP, Isenovic E Tags: Curr Med Chem Source Type: research

Natural Polymers Based Hydrogels for Cell Culture Applications.
Abstract It is well known that the extracellular matrix (ECM) plays a vital role in growth, survival and differentiation of cells. Though two-dimensional (2D) materials are generally used as substrates for the standard in vitro experiments, their mechanical, structural, and compositional characteristics can alter cell functions drastically. Many scientists reported that cells behave more natively when cultured in three-dimensional (3D) environments than on 2D substrates, due to the more in vivo-like 3D cell culture environment can mimic the biochemical and mechanical properties of the ECM. In this regard, water-sw...
Source: Current Medicinal Chemistry - September 3, 2019 Category: Chemistry Authors: Jose G, Shalumon KT, Chen JP, Yu C Tags: Curr Med Chem Source Type: research

The role of zinc and copper in insulin resistance and diabetes mellitus.
eth J Abstract The prevalence of type 2 diabetes mellitus (T2DM) is internationally ever-growing. Therefore, prevention, diagnostics, and control of insulin resistance and T2DM are of increasing importance. It has been suggested that mechanisms leading to insulin resistance and diabetes and its complications include high intake of refined and energy-rich food, which is presumed to be accompanied by suboptimal intake of trace elements, such as zinc (Zn), selenium (Se), chromium (Cr), and copper (Cu), which are essential and crucial for various biological processes. The purpose of this review is to highlight the rol...
Source: Current Medicinal Chemistry - September 2, 2019 Category: Chemistry Authors: Bjørklund G, Dadar M, Pivina L, Doşa MD, Semenova Y, Aaseth J Tags: Curr Med Chem Source Type: research

The Development of Lignocellulosic Biomass in Medicinal Applications.
Abstract PMID: 31453775 [PubMed - in process] (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - August 29, 2019 Category: Chemistry Authors: Si C Tags: Curr Med Chem Source Type: research

Alternatives Approaches to Treat Biofilm's Infections.
Abstract PMID: 31453776 [PubMed - in process] (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - August 29, 2019 Category: Chemistry Authors: Henriques M, Rodrigues CF Tags: Curr Med Chem Source Type: research

Metalloenzymes as Therapeutic Targets.
Abstract PMID: 31453777 [PubMed - in process] (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - August 29, 2019 Category: Chemistry Authors: Richichi B, Spyroulias GA, Winum JY, Žalubovskis R Tags: Curr Med Chem Source Type: research

Intranasal Nanoparticulate Systems as Alternative Route of Drug Delivery.
Abstract There is always a need for alternative and efficient methods of drug delivery. The nasal cavity can be considered as a non-invasive and efficient route of administration. It has been used for local, systemic, brain targeting, and vaccination delivery. Although, many intranasal products are currently available on the market, the majority is used for local delivery with fewer products available for the other targets. As nanotechnology utilization in the drug delivery has rapidly spread out, the nasal delivery has become attractive as a promising approach. Nanoparticulate systems facilitate drug transportati...
Source: Current Medicinal Chemistry - August 27, 2019 Category: Chemistry Authors: Alshweiat A, Ambrus R, Csoka I Tags: Curr Med Chem Source Type: research

Polyoxometalates in Biomedicine: Update and Overview.
CONCLUSIONS: Although a wide range of biological activities of polyoxometalates was reported, they are not close to clinical trials and the final application in the treatment of diabetes, infectious and malignant diseases. Accordingly, further studies should be directed towards delighting the mechanism of polyoxometalate biological actions, which would enable fine-tuning at the molecular level, and consequently efficient action towards biological targets and as low toxicity as possible. Furthermore, biomedical studies should be performed on solution-stable compounds under physiological conditions and concentrations employe...
Source: Current Medicinal Chemistry - August 27, 2019 Category: Chemistry Authors: Čolović M, Lacković M, Lalatović J, Mougharbel AS, Kortz U, Krstić DZ Tags: Curr Med Chem Source Type: research

The Tangled Mitochondrial Metabolism In Cancer: An Innovative Pharmacological Approach.
CONCLUSIONS: Mitochondria, also by ROS production, have a fundamental pathogenetic role in promoting and maintaining cancer and its spreading. To carefully understand the tangled redox state of cancer cells mitochondria represents a fundamental step to realize therapeutic approaches blocking the typical cancer progression. PMID: 31441723 [PubMed - as supplied by publisher] (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - August 23, 2019 Category: Chemistry Authors: Scatena R, Bottoni P Tags: Curr Med Chem Source Type: research

Molecular insights into the mechanisms underlying the cholesterol-lowering effects of phytosterols.
This article reviews the progress to date in research on the molecular mechanisms underlying the cholesterol-lowering effects of phytosterols. PMID: 31438826 [PubMed - as supplied by publisher] (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - August 22, 2019 Category: Chemistry Authors: Cedó L, Farràs M, Lee-Rueckert M, Escolà-Gil JC Tags: Curr Med Chem Source Type: research

Neutrophils as sentinel cells of the immune system: A role of the MPO-halide-system in innate and adaptive immunity.
Abstract For decades neutrophils were generally regarded as major cells of innate immunity with pro- inflammatory and phagocytic properties involved in a dual activity, beneficial (antimicrobial) and detrimental (tissue damage). Importantly, until discovery of toll-like receptors (TLRs), a role of neutrophils in adaptive immunity was limited to the effector stage of humoral response and phagocytosis of opsonized antigens. Moreover, in a common opinion, neutrophils as well as entire innate immune system were not functionally associated with adaptive immunity. At the time we demonstrated that protein chlorination by...
Source: Current Medicinal Chemistry - August 19, 2019 Category: Chemistry Authors: Marcinkiewicz J, Walczewska M Tags: Curr Med Chem Source Type: research

Chemical Mediators Expression Associated with the Modulation of Pain in Rheumatoid Arthritis.
Conclusion: The expression of all chemical mediators are directly related to RA and the modulation of pain by a complex intra and extracellular signaling pathway, however, transcription factors are involved in acute pain, while the ionic channels are involved in chronic pain in RA. . PMID: 31419924 [PubMed - as supplied by publisher] (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - August 16, 2019 Category: Chemistry Authors: L CJ, A MV, S RL, M G, Bandala C, D CC, A AR Tags: Curr Med Chem Source Type: research

Translational Theragnostic of Ovarian Cancer: Where do we stand?
Conclusion: This review aims at stimulating more multi-disciplinary efforts to identify a panel of novel and more specific biomarkers to be used to screen patients for a very early diagnosis, to have prognosis and therapy efficacy indications. The desired final goal would be to have available tools allowing to reduce the recurrence rate, increase both the disease progression free interval and of course the overall survival at five years from the diagnosis that today is still very low. . PMID: 31419925 [PubMed - as supplied by publisher] (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - August 16, 2019 Category: Chemistry Authors: Perrone MG, Luisi O, De Grassi A, Ferorelli S, Cormio G, Scilimati A Tags: Curr Med Chem Source Type: research