De novo adult acute myeloid leukemia with two new mutations in juxtatransmembrane domain of the FLT3 gene: a case report
ConclusionsTo the best of our knowledge, a combination of twoFLT3-ITD mutations in JMD together with anNPM1 type A mutation were not previously reported in adult AML. Further studies are necessary to prove or rule out whether the size of theseFLT3-ITDs mutations and potential other double mutations inFLT3-ITD are correlated with the observed adverse outcome. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - January 26, 2021 Category: General Medicine Source Type: research

COVID-19 myopericarditis with cardiac tamponade in the absence of respiratory symptoms: a case report
ConclusionsOur case demonstrates that patients without respiratory symptoms could have COVID-19 and develop cardiac complications. These findings can aid timely diagnosis of potentially life-threatening COVID-19 myopericarditis with cardiac tamponade. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - January 25, 2021 Category: General Medicine Source Type: research

Systemic lupus erythematosus manifestation following COVID-19: a case report
ConclusionsThis is the first case of SLE manifestation following COVID-19. SARS-CoV-2 may produce autoantibodies or develop the clinical features of subclinical SLE. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - January 25, 2021 Category: General Medicine Source Type: research

Genetic developmental disability diagnosed in adulthood: a case report
ConclusionsThis case highlights that the underlying cause of developmental delay is often multifactorial, and underscores the importance of a full medical evaluation, including genetic testing, for children with intellectual disability. Using this approach, healthcare professionals can identify potential diagnoses and provide more targeted resources to families. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - January 25, 2021 Category: General Medicine Source Type: research

Free air after laparoscopic hysterectomy; from sigmoid perforation to upper airway compromise: a case report
ConclusionsUpon mobilization of the patient, air from sigmoid perforation moved cephalad. Through the same path, pneumoperitoneum, causes subcutaneous emphysema in the neck and face, pneumomediastinum and pneumothorax. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - January 25, 2021 Category: General Medicine Source Type: research

Successful treatment with Cinryze ® replacement therapy of a pregnant patient with hereditary angioedema: a case report
ConclusionsIn the case presented, the angioedema attacks worsened as the pregnancy progressed. The treatment with Cinryze ® replacement therapy was effective and safe during pregnancy, with no adverse effects on the infant. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - January 24, 2021 Category: General Medicine Source Type: research

Faecopneumothorax due to missing diaphragmatic hernia: a case report
ConclusionsAcquired diaphragmatic hernia may be asymptomatic or may present with complications leading to sepsis. In this report, acquired diaphragmatic hernia and associated colonic perforation of a patient with a history of stab wounds was presented. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - January 23, 2021 Category: General Medicine Source Type: research

The pterional approach for the surgical resection of an orbital cholesteatoma: a case report
ConclusionsOur results support the use of the pterional craniotomy as a safe procedure for the surgical resection of cholesteatomas arising at the superotemporal walls of the orbit, with low postoperative morbidity. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - January 22, 2021 Category: General Medicine Source Type: research

The usefulness of measuring the anion gap in diagnosing metformin-associated lactic acidosis: a case series
ConclusionsIn patients with MALA, there is a significant variability in the anion gap values, which is not related to the level of metformin accumulation, and therefore, it is doubtful whether measuring anion gaps is useful as an approach for MALA diagnosis. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - January 21, 2021 Category: General Medicine Source Type: research

Intra-operative scleral rupture during 23 gauge pars plana vitrectomy: a case report
ConclusionPFCL injection, a crucial step of vitreoretina surgery, should be performed slowly with extreme caution maintaining an optimal intraocular pressure to prevent devastating complications like scleral rupture. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - January 20, 2021 Category: General Medicine Source Type: research

A late systemic and brain metastasis from subcutaneous leiomyosarcoma of the right forearm: a case report and review of the literature
ConclusionsLeiomyosarcomas represent a rare entity of mesenchymal tumors. Intracerebral metastasis of these tumors is even less frequent. This case shows the importance of long-term follow-up in patients with leiomyosarcoma. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - January 19, 2021 Category: General Medicine Source Type: research

An invasive mole with pulmonary metastases in a 55-year-old postmenopausal Syrian woman: a case report and review of the literature
ConclusionAlthough invasive moles in postmenopausal women have been reported previously, we believe our case is the first reported from Syria. Our case highlights the difficulties in diagnosing invasive moles in the absence of significant history of gestational trophoblastic diseases. The present study further reviews the diagnostic methods, histological characteristics and treatment recommendations. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - January 18, 2021 Category: General Medicine Source Type: research

Synovial sarcoma of the hand-wrist: a case report and review of the literature
ConclusionsThis paper aims to characterize the demographic, pathologic, and clinical features with a literature review. The present literature review confirms that hand-wrist synovial sarcomas are more frequent among males and subjects 10 to 40 years old. Most cases in this location are usually not larger than 5 cm in size. The five-year survival rate is higher than that reported in a previous review on hand synovial sarcomas, and this suggests an improved survival in recent decades. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - January 17, 2021 Category: General Medicine Source Type: research

Suicidal attempt with caffeine overdose treated with dexmedetomidine: a case report
ConclusionCases of acute caffeine intoxication with agitation, sympathetic overactivity and adverse cardiac events would benefit with dexmedetomidine treatment. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - January 16, 2021 Category: General Medicine Source Type: research

Retinal imaging study diagnoses in  COVID-19: a case report
ConclusionsOcular signs and symptoms in COVID-19 cases are rarely reported, but may be underestimated, especially those that affect the retina and occur in asymptomatic or paucisymptomatic cases. We present a case of COVID-19 diagnosis based on retinal ophthalmic examination. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - January 15, 2021 Category: General Medicine Source Type: research

Intestinal obstruction due to small bowel herniation through foramen of Winslow: a case report  
ConclusionSince delayed diagnosis of bowel obstruction is detrimental, it is of utmost importance to diagnose it early. Because internal herniation of the small bowel through the foramen of Winslow presents with nonspecific symptoms including features of gastroesophageal reflux disease, as documented in several cases worldwide and also presented by our patient, there should be a high degree of suspicion of internal herniation of the bowel causing bowel obstruction and low threshold for extensive investigation of patients presenting with symptoms of gastroesophageal reflux disease which does not resolve with usual medicatio...
Source: Journal of Medical Case Reports - January 15, 2021 Category: General Medicine Source Type: research

Delayed management of atrial lead dislodgment after pacemaker implantation: a case report
ConclusionsFor patients with sick sinus syndrome with dual-chamber pacemaker indication, atrial lead dislodgement should be appropriately managed if the atrioventricular function is normal. As the consequences are subtle and appear gradually, they might be overlooked by patients and even doctors. Implanting a new atrial lead is the right thing to do rather than just passively waiting or treating with symptom relief medications. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - January 14, 2021 Category: General Medicine Source Type: research

Unilateral lower limb atrophy associated with glomus tumors: a case report
ConclusionThis case suggests that small glomus tumors located in deep tissue may cause disuse atrophy because of their long delay before diagnosis. Clinicians should consider the potential for glomus tumors when patients exhibit unilateral lower limb muscular atrophy with pain. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - January 13, 2021 Category: General Medicine Source Type: research

Ovarian borderline tumor presenting as ovarian torsion in a 17-year-old patient: a case report
ConclusionsMalignant ovarian torsion in pediatric age groups is rare. Ultrasound examination should be recognized as a powerful tool for diagnosis and management, especially when performed by an experienced ultrasonographer. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - January 12, 2021 Category: General Medicine Source Type: research

Effective treatment of osmotic demyelination syndrome with plasmapheresis: a case report and review of the literature
ConclusionPlasmapheresis can be considered as an effective treatment modality in chronic osmotic demyelination syndrome. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - January 11, 2021 Category: General Medicine Source Type: research

Familial chylomicronemia syndrome: a case report
ConclusionsOur case reports an extremely rare and fatal condition and illustrated the significance of timely diagnosis and intervention for saving the life of the baby. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - January 8, 2021 Category: General Medicine Source Type: research

A solitary brain metastasis as the only site of recurrence of HR positive, HER2 negative breast cancer: a case report and review of the literature
ConclusionBased on our case, although rare, patients with treated, operable, hormone receptor positive, HER2 negative breast cancer can present with solitary brain metastasis as the only sign of disease recurrence. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - January 7, 2021 Category: General Medicine Source Type: research

A severe case of thrombocytopenia, anasarca, fever, renal insufficiency or reticulin fibrosis, and organomegaly syndrome with myocardial and skeletal muscle calcification despite hypocalcemia: a case report
ConclusionThis is the first report of a patient with TAFRO syndrome and the complication of organ calcification. The etiology of calcification in this case is not clear. Systemic inflammation with possible hypercytokinemia might have been involved in the unexpected complication of systemic calcification. It is important to carefully handle the general management of TAFRO syndrome because of the possibility of various complications. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - January 6, 2021 Category: General Medicine Source Type: research

Clostridium difficile appendicitis in an immunocompromised patient: a case report and review of the literature
ConclusionsOur case highlights the importance of maintaining a high index of suspicion forC. difficile in a patient presenting with both appendicitis and colitis, with prompt diagnosis and treatment being essential. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - January 5, 2021 Category: General Medicine Source Type: research

The utility of hyperbaric oxygen therapy in post-transplant cyclophosphamide-induced hemorrhagic cystitis: a case report and review of the  literature
ConclusionHBO can be a safe, noninvasive, alternative treatment modality for PTCy-induced HC developing in allogeneic SCT patients. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - January 4, 2021 Category: General Medicine Source Type: research

Late-onset myocardial infarction and autoimmune haemolytic anaemia in a COVID-19 patient without respiratory symptoms, concomitant with a paradoxical increase in inflammatory markers: a case report
ConclusionsBoth complications occurred quite late after COVID-19 diagnosis and were probably precipitated by systemic inflammation, as indicated by a significant delayed increase in inflammatory markers, including interleukin-6 (IL-6). (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - December 18, 2020 Category: General Medicine Source Type: research

Double-hit lymphoma of the male breast: a case report
ConclusionThe present case adds to the understanding of the pathogenesis of male breast lymphomas, about which hardly any molecular characterization has been published  yet. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - December 18, 2020 Category: General Medicine Source Type: research

Incidental squamous cell carcinoma of renal pelvis presenting as skin invasion: a case report
ConclusionIt is extremely rare for renal squamous cell carcinoma to present as skin invasion. Recurrent percutaneous nephrolithotomy may be a risk factor for squamous cell carcinoma of the renal pelvis. The possibility of renal squamous cell carcinoma should be kept in mind in patients who have hydronephrosis, nephrolithiasis, or chronic pyelonephritis for a long time or with renal anomalies. More radiological examinations are suggested for such patients. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - December 15, 2020 Category: General Medicine Source Type: research

A retrospective study of 323 total laparoscopic hysterectomy cases for various indications and a case report treating caesarean scar pregnancy
ConclusionsConsidering the factors detected in this analysis, the indications for TLH may be expanded. Owing to the increase in TLH for indications other than leiomyoma/adenomyoma, a more accurate determination of the treatment approach can be achieved. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - December 14, 2020 Category: General Medicine Source Type: research

Detection of SARS-CoV-2 pneumonia: two case reports  
ConclusionsNegative PCR findings in both the pharynx and bronchoalveolar lavage do not exclude COVID-19 pneumonia. Computed tomography is a crucial diagnostic prerequisite in this context. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - December 11, 2020 Category: General Medicine Source Type: research

Bilateral hypotropic dissociated vertical deviation: a case report  
ConclusionThis is a rare case of hypotropic DVD showing bilateral hypotropic DVD with different characteristics from those previously reported cases (bilateral hypotropic DVD with intermittent exotropia, dissociated horizontal deviation, manifest latent nystagmus, and bilateral inferior oblique overaction). The hypotropic DVD only appeared when covering each eye, and thus there was no need for surgery. Moreover, the inferior oblique recession did not seem to negatively affect the appearance of the eyes. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - December 10, 2020 Category: General Medicine Source Type: research

Catecholaminergic polymorphic ventricular tachycardia in pregnancy: a case report
ConclusionsCPVT is likely underdiagnosed and, given that cardiovascular disease is a leading cause of death in pregnancy, it is important to bring further awareness to the diagnosis and management of this inherited arrhythmia syndrome in pregnancy. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - December 9, 2020 Category: General Medicine Source Type: research

Unexpected tumor response to palliative pelvic radiotherapy in mismatch repair-deficient advanced prostate cancer: a case report
ConclusionsRoutine evaluation of MSI in patients with locally problematic advanced tumors might change treatment strategy and treatment aim in this setting, from a purely palliative approach to a quasi-curative paradigm. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - December 8, 2020 Category: General Medicine Source Type: research

Use of low-molecular-weight heparin in severe paraquat poisoning: a case report
ConclusionsAlthough the amount of paraquat ingested by the patient was large and the UDT indicated severe poisoning with a somber prognosis, unexpected survival of the patient was observed, and the addition of enoxaparin was the only change from the standard treatment. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - December 8, 2020 Category: General Medicine Source Type: research

Recurrent obstructive uropathy secondary to pyometrocolpos in an 8-month-old infant: a case report
ConclusionPyometrocolpos is rare in childhood but should be suspected in a girl presenting with a midline lower abdominal mass accompanied with urinary obstructive symptoms associated with fever and gastrointestinal symptoms.Escherichia coli seems to be the most probable offending organism, but pus culture is crucial for antibiotic stewardship in proper management of the infection. Definitive treatment should focus on correcting the obstructive anatomical congenital deformity that caused the obstruction in order to avoid recurrence. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - December 7, 2020 Category: General Medicine Source Type: research

Refractory secondary pneumothorax complicated with lung cancer treated by bronchial occlusion: a case report
ConclusionsRefractory secondary pneumothorax, which affected multiple bronchi and developed into collateral ventilation due to lung cancer, was treated successfully with bronchial occlusion and EWS. In cases where the affected bronchi cannot be determined by the balloon occlusion test, bronchography with iopamidol might be an effective treatment. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - December 5, 2020 Category: General Medicine Source Type: research

Treatment of pseudobulbar affect (PBA) in a patient with a history of traumatic brain injury, partial brain resection, and brainstem stroke: a case report
ConclusionsThis case provides anecdotal evidence for the efficacy of dextromethorphan/quinidine in the treatment of pseudobulbar affect with remarkably swift and complete cessation of symptoms. As a secondary point, it is worth noting that our  patient had experienced two devastating neurological traumas, both in anatomical areas that have been implicated in the corticopontine–cerebellar circuit thought to be responsible for pseudobulbar affect. However, only the second trauma, an acute left pontine infarction, produced symptoms of emo tional disinhibition. The authors hope that reporting this case will provide ...
Source: Journal of Medical Case Reports - December 4, 2020 Category: General Medicine Source Type: research

Gastric carcinoma and renal cell carcinoma as an atypical presentation of multiple primary malignancies: a  case report and review of the literature
ConclusionGastric carcinoma is the second most frequent neoplasm of the GI tract and the main neoplasm that presents a SPM. MPM screening is recommended in patients with gastric cancer. The clinical discovery of MPM of renal origin is rare and hence the importance of the current report. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - December 2, 2020 Category: General Medicine Source Type: research

Genetic and histopathological analysis of transverse testicular ectopia without persistent M üllerian duct syndrome: two case reports
ConclusionsBecause UTF1, a specific marker of spermatogonial stem cell activity, was expressed in both the affected and unaffected sides in the testicular tissues of two patients, the risk of malignancy may be high in these patients. Although the etiology of TTE without PMDS remains unclear, our variant analysis results were consistent with previous reports, and variants in theAMH gene (rs10407022) may contribute to the specific phenotype of TTE without PMDS. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - December 1, 2020 Category: General Medicine Source Type: research

An abnormal course of the interazygos vein: a case report
ConclusionsThis variation is important in mediastinal surgery and radiographic interpretation. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - November 30, 2020 Category: General Medicine Source Type: research

Complex cytogenetic abnormalities in chronic myeloid leukemia resulting in early progression to blast crisis: a case report
ConclusionCytogenetic monitoring is an important pillar in the management of patients with chronic myeloid leukemia that cannot be ignored. It should therefore be a part of patient management not only during diagnosis but also during management. We present an unusual cytogenetic abnormality in a patient with chronic myeloid leukemia that resulted in early disease progression. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - November 27, 2020 Category: General Medicine Source Type: research

Ursodeoxycholic acid and bezafibrate were useful for steroid-refractory, immune-related hepatitis: a case report
ConclusionsUrsodeoxycholic acid and bezafibrate may be useful for treatment of steroid-refractory immune-related adverse event hepatitis. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - November 26, 2020 Category: General Medicine Source Type: research

Partial laryngectomy and reconstruction with rotation of the epiglottis in the treatment of a rare laryngeal schwannoma: a case report
ConclusionThe definitive diagnosis of laryngeal lesions can be difficult, and histopathology plays a pivotal role. Laryngeal schwannomas are rare; however, tumors can become large and may ultimately lead to airway obstruction. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - November 25, 2020 Category: General Medicine Source Type: research

Bladder rupture due to urogenital tract trauma caused by ox horn injury in a patient with pelvic organ prolapse: a case report
ConclusionOx horn injury involving the female lower urogenital tract in the presence of POP is extremely rare. Late presentation after sustaining injury is associated with increased risk of morbidity and long hospital stay, and treatment requires multistage surgery. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - November 24, 2020 Category: General Medicine Source Type: research

Acute respiratory failure as initial manifestation of conventional osteosarcoma rich in giant cells: a  case report
ConclusionsThe giant cell-rich osteosarcoma is a very rare histological variant of conventional osteosarcoma. Few cases of this type of osteosarcoma originating from the spine have been reported in the literature, and to our knowledge none of the reported cases included invasion to the chest cavity with airway compression and fatal acute respiratory failure that was present our case. Radiological and histological features of the GCRO must be taken into account to make a prompt diagnosis. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - November 23, 2020 Category: General Medicine Source Type: research

Intimal angiosarcoma of the thoracic aorta diagnosed by endobronchial ultrasound-guided transbronchial needle aspiration: a case report
ConclusionTumors of the aorta are rare and difficult to diagnose; they are a challenge during the diagnosis, since they usually require open surgical procedures. Endobronchial ultrasound-guided transbronchial needle aspiration associated with rapid on-site examination offered, in this case, the possibility of a successful diagnosis, avoiding major procedures. This is the first case reported in the literature of an intimal angiosarcoma of the thoracic aorta diagnosed using endobronchial ultrasound-guided transbronchial needle aspiration. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - November 21, 2020 Category: General Medicine Source Type: research

Cabozantinib as the causative agent of high-grade fever in a patient with a background of metastatic clear cell renal cell carcinoma: a case report
ConclusionsWe have demonstrated that cabozantinib should always be considered in the aetiology of high-grade fever in relevant patients. Further, we demonstrate that temporary cessation of cabozantinib and a course of short-term steroids can induce resolution of fever and allow for recommencement of cabozantinib safely thereafter. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - November 20, 2020 Category: General Medicine Source Type: research

Peripheral vascular disease – a new vascular disease associated with normal tension glaucoma: a case report
ConclusionAfter ruling out other systemic diseases and vascular abnormalities related to normal-tension glaucoma, we found peripheral arterial disease as a probable vascular abnormality related to normal-tension glaucoma in our patient. To our knowledge, this is the first time such a case has been reported. Thus, further research is needed to determine the relevance of these results to the general population. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - November 19, 2020 Category: General Medicine Source Type: research

Development of pre-syrinx state and syringomyelia following a minor injury: a case report
ConclusionsWe conclude that even after a minor trauma PTS can occur and that medullary edema (pre-syrinx state) may precede syrinx formation. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - November 18, 2020 Category: General Medicine Source Type: research

Three distinct hematological malignancies from a single germ cell tumor: a case report
ConclusionsThis is an extreme case that highlights the pluripotency and aggressiveness of these GCT-derived hematological malignancies, and the need for novel therapeutic approaches. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - November 17, 2020 Category: General Medicine Source Type: research