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Harnessing the Therapeutic Potential of Antimicrobial peptides for cancers: State of the art
Curr Top Med Chem. 2023 Mar 28. doi: 10.2174/1568026623666230328161236. Online ahead of print.ABSTRACTDespite significant breakthroughs in cancer treatment, cancer remains a serious global health concern that takes thousands of lives each year. Still, drug resistance and adverse effects are the main problems in conventional cancer therapeutic approaches. Thus, the discovery of new anti-cancer agents with distinct mechanisms of action is a critical requirement that offers significant obstacles. Antimicrobial peptides (AMPs), which can be found in various forms of life, are recognized as defensive weapons against infections ...
Source: Current Topics in Medicinal Chemistry - March 30, 2023 Category: Chemistry Authors: Maryam Mahjoubin-Tehran Samaneh Rezaei Seyed Hamid Aghaee-Bakhtiari Amirhossein Sahebkar Reza Kazemi Oskuee Ali Mahmoudi Amin Jalili Source Type: research

Natural Products as Potential Therapeutic Agents for SARS-CoV-2: A Medicinal Chemistry Perspective
Curr Top Med Chem. 2023 Mar 27. doi: 10.2174/1568026623666230327125918. Online ahead of print.ABSTRACTCoronavirus is a single-stranded RNA virus discovered by virologist David Tyrrell in 1960. Till now seven human corona viruses have been identified including HCoV-229E, HCoV-OC43, HCoV-NL63, HCoV-HKU1, SARS-CoV, MERS-CoV and SARS-CoV-2. In the present scenario, the SARS-CoV-2 outbreak causing SARS-CoV-2 pandemic, became the most serious public health emergency of the century worldwide. Natural products have long history and advantages for the drug discovery process. Almost 80% of drugs present in market are evolved from th...
Source: Current Topics in Medicinal Chemistry - March 28, 2023 Category: Chemistry Authors: Varun Aggarwal Ekta Bala Pawan Kumar Pankaj Raizada Pardeep Singh Praveen Kumar Verma Source Type: research

Propolis: Antineoplastic Activity, Constituents, and Mechanisms of Action
CONCLUSION: A summary of several antiproliferative activities of different types of propolis is exposed. The potential health benefits of propolis are discussed. The variable plant origin of propolis partially accounts for its anti-cancer activities. Even when some mechanisms of action of propolis have been proposed, much of the genesis of how this effect is produced is yet to be answered, including several molecular mechanisms in different biological systems.PMID:36959133 | DOI:10.2174/1568026623666230321120631 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - March 24, 2023 Category: Chemistry Authors: Patricia Ruiz-Bustos Efrain Alday Adriana Garibay-Escobar Jose Mauricio Sforcin Yulia Lipovka Javier Hernandez Carlos Arturo Vel ázquez-Contreras Source Type: research

Challenges and Discoveries in Polypharmacology
Curr Top Med Chem. 2023;23(5):331-333. doi: 10.2174/156802662305230217155933.NO ABSTRACTPMID:36960645 | DOI:10.2174/156802662305230217155933 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - March 24, 2023 Category: Chemistry Authors: Marcus T Scotti Luciana Scotti Source Type: research

Ionizing Radiation: Chemical kinetics, chemical bounds, and radiation chemistry on polymers
Curr Top Med Chem. 2023 Mar 15. doi: 10.2174/1568026623666230315122855. Online ahead of print.ABSTRACTIonizing radiation has been used for decades and expanded to several applications in multivariate sectors, becoming an important tool to promote controlled chemical reactions in polymeric structures, according to their chemical properties for developing new materials. In addition, the use of radiation can also be applied in order to reduce or eliminate compounds from solutions that may be harmful or of low interest. In this review, we overviewed the chemistry behind material irradiation and the attractive use of ionizing r...
Source: Current Topics in Medicinal Chemistry - March 16, 2023 Category: Chemistry Authors: Martha Sahyl í Ortega Pijeira Tais Monteiro Magne Nat ália Cristina Gomes da Silva Elisabete Regina Fernandes Ramos Ribeiro Yuri Jos é Albuquerque Silva Eduardo Ricci-Junior Luciana Magalh ães Rebelo Alencar Ralph Santos-Oliveira Source Type: research