Reassessing the Net Benefit of Cancer Drugs With Evolution of Evidence Using the ASCO Value Framework
CONCLUSIONS: Because there were changes in classification for more than one-quarter of indications, in either direction, reassessing the ASCO-VF NHB as more evidence becomes available may be beneficial to inform clinical shared decision-making. On average, there was no overall improvement in the ASCO-VF NHB with longer follow-up and evolution of evidence.PMID:33636693 | DOI:10.6004/jnccn.2020.7677 (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - February 26, 2021 Category: Cancer & Oncology Authors: Seanthel Delos Santos Noah Witzke Bishal Gyawali Vanessa Sarah Arciero Amanda Putri Rahmadian Louis Everest Matthew C Cheung Kelvin K Chan Source Type: research

SOURCE: Prediction Models for Overall Survival in Patients With Metastatic and Potentially Curable Esophageal and Gastric Cancer
CONCLUSIONS: The SOURCE prediction models show fair to good c-indices and an overall good calibration. The models are the first in esophageal and gastric cancer to predict survival at diagnosis for a variety of treatments. Future research is needed to demonstrate their value for shared decision-making in clinical practice.PMID:33636694 | DOI:10.6004/jnccn.2020.7631 (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - February 26, 2021 Category: Cancer & Oncology Authors: H éctor G van den Boorn Ameen Abu-Hanna Nadia Haj Mohammad Maarten C C M Hulshof Suzanne S Gisbertz Bastiaan R Klarenbeek Marije Slingerland Laurens V Beerepoot Tom Rozema Mirjam A G Sprangers Rob H A Verhoeven Martijn G H van Oijen Koos H Zwinderman Han Source Type: research

Reassessing the Net Benefit of Cancer Drugs With Evolution of Evidence Using the ASCO Value Framework
CONCLUSIONS: Because there were changes in classification for more than one-quarter of indications, in either direction, reassessing the ASCO-VF NHB as more evidence becomes available may be beneficial to inform clinical shared decision-making. On average, there was no overall improvement in the ASCO-VF NHB with longer follow-up and evolution of evidence.PMID:33636693 | DOI:10.6004/jnccn.2020.7677 (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - February 26, 2021 Category: Cancer & Oncology Authors: Seanthel Delos Santos Noah Witzke Bishal Gyawali Vanessa Sarah Arciero Amanda Putri Rahmadian Louis Everest Matthew C Cheung Kelvin K Chan Source Type: research

SOURCE: Prediction Models for Overall Survival in Patients With Metastatic and Potentially Curable Esophageal and Gastric Cancer
CONCLUSIONS: The SOURCE prediction models show fair to good c-indices and an overall good calibration. The models are the first in esophageal and gastric cancer to predict survival at diagnosis for a variety of treatments. Future research is needed to demonstrate their value for shared decision-making in clinical practice.PMID:33636694 | DOI:10.6004/jnccn.2020.7631 (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - February 26, 2021 Category: Cancer & Oncology Authors: H éctor G van den Boorn Ameen Abu-Hanna Nadia Haj Mohammad Maarten C C M Hulshof Suzanne S Gisbertz Bastiaan R Klarenbeek Marije Slingerland Laurens V Beerepoot Tom Rozema Mirjam A G Sprangers Rob H A Verhoeven Martijn G H van Oijen Koos H Zwinderman Han Source Type: research

Reassessing the Net Benefit of Cancer Drugs With Evolution of Evidence Using the ASCO Value Framework
CONCLUSIONS: Because there were changes in classification for more than one-quarter of indications, in either direction, reassessing the ASCO-VF NHB as more evidence becomes available may be beneficial to inform clinical shared decision-making. On average, there was no overall improvement in the ASCO-VF NHB with longer follow-up and evolution of evidence.PMID:33636693 | DOI:10.6004/jnccn.2020.7677 (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - February 26, 2021 Category: Cancer & Oncology Authors: Seanthel Delos Santos Noah Witzke Bishal Gyawali Vanessa Sarah Arciero Amanda Putri Rahmadian Louis Everest Matthew C Cheung Kelvin K Chan Source Type: research

SOURCE: Prediction Models for Overall Survival in Patients With Metastatic and Potentially Curable Esophageal and Gastric Cancer
CONCLUSIONS: The SOURCE prediction models show fair to good c-indices and an overall good calibration. The models are the first in esophageal and gastric cancer to predict survival at diagnosis for a variety of treatments. Future research is needed to demonstrate their value for shared decision-making in clinical practice.PMID:33636694 | DOI:10.6004/jnccn.2020.7631 (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - February 26, 2021 Category: Cancer & Oncology Authors: H éctor G van den Boorn Ameen Abu-Hanna Nadia Haj Mohammad Maarten C C M Hulshof Suzanne S Gisbertz Bastiaan R Klarenbeek Marije Slingerland Laurens V Beerepoot Tom Rozema Mirjam A G Sprangers Rob H A Verhoeven Martijn G H van Oijen Koos H Zwinderman Han Source Type: research

Reassessing the Net Benefit of Cancer Drugs With Evolution of Evidence Using the ASCO Value Framework
CONCLUSIONS: Because there were changes in classification for more than one-quarter of indications, in either direction, reassessing the ASCO-VF NHB as more evidence becomes available may be beneficial to inform clinical shared decision-making. On average, there was no overall improvement in the ASCO-VF NHB with longer follow-up and evolution of evidence.PMID:33636693 | DOI:10.6004/jnccn.2020.7677 (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - February 26, 2021 Category: Cancer & Oncology Authors: Seanthel Delos Santos Noah Witzke Bishal Gyawali Vanessa Sarah Arciero Amanda Putri Rahmadian Louis Everest Matthew C Cheung Kelvin K Chan Source Type: research

SOURCE: Prediction Models for Overall Survival in Patients With Metastatic and Potentially Curable Esophageal and Gastric Cancer
CONCLUSIONS: The SOURCE prediction models show fair to good c-indices and an overall good calibration. The models are the first in esophageal and gastric cancer to predict survival at diagnosis for a variety of treatments. Future research is needed to demonstrate their value for shared decision-making in clinical practice.PMID:33636694 | DOI:10.6004/jnccn.2020.7631 (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - February 26, 2021 Category: Cancer & Oncology Authors: H éctor G van den Boorn Ameen Abu-Hanna Nadia Haj Mohammad Maarten C C M Hulshof Suzanne S Gisbertz Bastiaan R Klarenbeek Marije Slingerland Laurens V Beerepoot Tom Rozema Mirjam A G Sprangers Rob H A Verhoeven Martijn G H van Oijen Koos H Zwinderman Han Source Type: research

Priorities of Unmet Needs for Those Affected by Colorectal Cancer: Considerations From a Series of Nominal Group Technique Sessions.
CONCLUSIONS: These findings highlight gaps in support for individuals affected by CRC, and lay a foundation for ongoing assistance. Future studies exploring differences based on disease stage, race/ethnicity, age, gender identity, geographic location, and tumor location are needed to further tailor support for those experiencing CRC. Themes identified in this project require a multidisciplinary approach to ensure that the unmet needs of survivors are addressed. PMID: 33607609 [PubMed - as supplied by publisher] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - February 21, 2021 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Uptake Rates of Novel Therapies and Survival Among Privately Insured Versus Publicly Insured Patients With Colorectal Cancer in Germany.
CONCLUSIONS: We observed major differences in uptake of targeted therapy between patients with PHI and those with SHI but no differences in patient survival after adjusting for relevant sociodemographic, clinical, and tumor characteristics. Further studies are needed on factors associated with the uptake of therapeutic innovations and their impact on patient survival by health insurance type. PMID: 33578373 [PubMed - as supplied by publisher] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - February 13, 2021 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Prognosis of Incidental Brain Metastases in Patients With Advanced Renal Cell Carcinoma.
CONCLUSIONS: This large multi-institutional mRCC cohort study identified occult brain metastasis in a notable proportion of patients (4.3%) and highlights that the risk of asymptomatic CNS involvement extends to those with favorable risk features per IMDC risk assessment. These data provide rationale for brain screening in patients with advanced RCC. PMID: 33578374 [PubMed - as supplied by publisher] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - February 13, 2021 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Variation in Use of High-Cost Technologies for Palliative Radiation Therapy by Radiation Oncologists.
CONCLUSIONS: Differences in radiation oncologists' practice and choices, rather than differences in patient case-mix, accounted for a greater proportion of the variation in the use of advanced technologies and high-cost radiation services. PMID: 33578375 [PubMed - as supplied by publisher] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - February 13, 2021 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Medicare/Medicaid Insurance, Rurality, and Black Race Associated With Provision of Hepatocellular Carcinoma Treatment and Survival.
Authors: Moon AM, Sanoff HK, Chang Y, Lund JL, Barritt AS, Hayashi PH, Stitzenberg KB Abstract BACKGROUND: Early treatment of hepatocellular carcinoma (HCC) is associated with improved survival, but many patients with HCC do not receive therapy. We aimed to examine factors associated with HCC treatment and survival among incident patients with HCC in a statewide cancer registry. MATERIALS AND METHODS: All patients with HCC from 2003 through 2013 were identified in the North Carolina cancer registry. These patients were linked to insurance claims from Medicare, Medicaid, and large private insurers in North Carol...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - February 13, 2021 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Sex- and Age-Related Differences in the Distribution of Metastases in Patients With Upper Urinary Tract Urothelial Carcinoma.
CONCLUSIONS: Lung, bone, and liver metastases are the most common metastatic sites in both sexes. However, the distribution of metastases varies according to sex and age. These observations apply to everyday clinical practice and may be used, for example, to advocate for universal bone imaging in patients with UTUC. Moreover, our findings may also be used for design considerations of randomized trials. PMID: 33571954 [PubMed - as supplied by publisher] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - February 12, 2021 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Barriers to Optimal End-of-Life Care for Adolescents and Young Adults With Cancer: Bereaved Caregiver Perspectives.
CONCLUSIONS: Bereaved family caregivers of AYAs with cancer noted a need for timely prognostic communication, emotional support to enhance acceptance of a poor prognosis, and care delivery models that would support both life-prolonging and palliative goals of care. Work to address these challenges offers the potential to improve the quality of EoL care for young people with cancer. PMID: 33571955 [PubMed - as supplied by publisher] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - February 12, 2021 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Impact of Facility Surgical Volume on Survival in Patients With Cancer.
CONCLUSIONS: Patients treated surgically at higher-volume facilities consistently had improved overall survival compared with those treated at low-volume centers, although the magnitude of difference was cancer-specific. PMID: 33561825 [PubMed - as supplied by publisher] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - February 11, 2021 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Radiotherapy Remains Underused in the Treatment of Soft-Tissue Sarcomas: Disparities in Practice Patterns in the United States.
CONCLUSIONS: Although use of neoadjuvant RT and IMRT has increased over time, a significant number of patients with STS are not receiving adjuvant or neoadjuvant RT. Our findings also note potential sociodemographic disparities and highlight the concern that not all patients with STS are being equally considered for RT. PMID: 33556919 [PubMed - as supplied by publisher] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - February 9, 2021 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Status of the Clinician Investigator in America: An Essential Healthcare Provider Driving Advances in Cancer Care.
CONCLUSIONS: This study highlights the importance of the CI in translational cancer medicine and represents a call to action for institutions and research funding agencies to develop new programs targeted toward CI support to ensure continued progress against cancer. PMID: 33545684 [PubMed - as supplied by publisher] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - February 6, 2021 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Tumor Mutational Burden and Mismatch Repair Deficiency Discordance as a Mechanism of Immunotherapy Resistance.
This report describes 3 patients with Lynch syndrome who each had 2 primary malignancies: 1 with dMMR and a high tumor mutational burden (TMB), and 1 with dMMR but, unexpectedly, a low TMB. Two of these patients received immunotherapy for their TMB-low tumors but experienced no response. We have found that not all Lynch-associated dMMR tumors have a high TMB and propose that tumors with dMMR and TMB discordance may be resistant to immunotherapy. The possibility of dMMR/TMB discordance should be considered, particularly in less-typical Lynch cancers, in which TMB evaluation could guide the use of immune checkpoint inhibitor...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - February 6, 2021 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Learning From Our Mistakes.
Authors: Tempero M PMID: 33545686 [PubMed - as supplied by publisher] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - February 6, 2021 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

The Impact of Early Referrals to Dietitians for Patients With Esophagogastric Cancer.
Authors: Roeland EJ, Dunne RF PMID: 33545687 [PubMed - as supplied by publisher] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - February 6, 2021 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Cost-Effectiveness of Durvalumab After Chemoradiotherapy in Unresectable Stage III NSCLC: A US Healthcare Perspective.
CONCLUSIONS: In a US healthcare setting, durvalumab was cost-effective compared with cCRT alone, further supporting the adoption of durvalumab following cCRT as the new standard of care in patients with unresectable stage III NSCLC. PMID: 33545688 [PubMed - as supplied by publisher] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - February 6, 2021 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

NCCN Guidelines Insights: Prostate Cancer, Version 1.2021.
This article summarizes the panel's discussions for the 2021 update of the guidelines with regard to systemic therapy for metastatic castration-resistant prostate cancer. PMID: 33545689 [PubMed - as supplied by publisher] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - February 6, 2021 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Ovarian Cancer, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology.
Authors: Armstrong DK, Alvarez RD, Bakkum-Gamez JN, Barroilhet L, Behbakht K, Berchuck A, Chen LM, Cristea M, DeRosa M, Eisenhauer EL, Gershenson DM, Gray HJ, Grisham R, Hakam A, Jain A, Karam A, Konecny GE, Leath CA, Liu J, Mahdi H, Martin L, Matei D, McHale M, McLean K, Miller DS, O'Malley DM, Percac-Lima S, Ratner E, Remmenga SW, Vargas R, Werner TL, Zsiros E, Burns JL, Engh AM Abstract Epithelial ovarian cancer is the leading cause of death from gynecologic cancer in the United States and is the country's fifth most common cause of cancer mortality in women. A major challenge in treating ovarian cancer is that ...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - February 6, 2021 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Microsatellite Instability and KRAS Mutation in Stage IV Colorectal Cancer: Prevalence, Geographic Discrepancies, and Outcomes From the National Cancer Database.
This study sought to assess microsatellite and KRAS status, prevalence, and impact on outcome in stage IV colorectal cancer (CRC). MATERIALS AND METHODS: The 2010 to 2016 US National Cancer Database was queried for adult patients with stage IV CRC. Prevalence of microsatellite status (microsatellite instability-high [MSI-H] or microsatellite stable [MSS]) and KRAS status (KRAS mutation or wild-type) of the primary CRC was assessed. Overall survival (OS) was evaluated using multivariable Cox proportional hazards models in patients with complete data on both microsatellite and KRAS status and information on follow-up. ...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - February 3, 2021 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Prevalence of Anemia and Compliance With NCCN Guidelines for Evaluation and Treatment of Anemia in Patients With Gynecologic Cancer.
CONCLUSIONS: Anemia is pervasive among patients with gynecologic cancer, but compliance with the NCCN Guidelines is low. Our data suggest that there are opportunities for improvement in the evaluation and management of anemia. PMID: 33524941 [PubMed - as supplied by publisher] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - February 2, 2021 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Impact of the Examined Numbers and Stations of Lymph Nodes on Precise Staging and Survival in Radiologically Pure-Solid Lung Cancer.
This study sought to determine the optimal number of examined lymph nodes (ELNs) and examined node stations (ENSs) in patients with radiologically pure-solid non-small cell lung cancer (NSCLC) who underwent lobectomy and ipsilateral lymphadenectomy by investigating the impact of ELNs and ENSs on accurate staging and long-term survival. MATERIALS AND METHODS: Data from 6 institutions in China on resected clinical stage I-II (cI-II) NSCLCs presenting as pure-solid tumors were analyzed for the impact of ELNs and ENSs on nodal upstaging, stage migration, recurrence-free survival (RFS), and overall survival (OS). Correlatio...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - January 30, 2021 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Associations of Skeletal Muscle With Symptom Burden and Clinical Outcomes in Hospitalized Patients With Advanced Cancer.
Authors: van Seventer E, Marquardt JP, Troschel AS, Best TD, Horick N, Azoba C, Newcomb R, Roeland EJ, Rosenthal M, Bridge CP, Greer JA, El-Jawahri A, Temel J, Fintelmann FJ, Nipp RD Abstract BACKGROUND: Low muscle mass (quantity) is common in patients with advanced cancer, but little is known about muscle radiodensity (quality). We sought to describe the associations of muscle mass and radiodensity with symptom burden, healthcare use, and survival in hospitalized patients with advanced cancer. METHODS: We prospectively enrolled hospitalized patients with advanced cancer from September 2014 through May 2016. Up...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - January 30, 2021 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

End-of-Life Characteristics Associated With Short Hospice Length of Stay for Patients With Solid Tumors Enrolled in Phase I Clinical Trials.
Authors: Sedhom R, Blackford AL, Gupta A, Griffiths K, Heussner J, Carducci MA Abstract BACKGROUND: Patients participating in phase I trials represent a population with advanced cancer and symptoms, with quality-of-life implications arising from both disease and treatment. Transitions to end-of-life care for these patients have received little attention. Good empirical data are needed to better understand the role of advance care planning and palliative care during phase I trial transitions. We investigated how physician-patient communication at the time of disease progression, patient characteristics, and patterns...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - January 23, 2021 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Association of Polypharmacy and Potentially Inappropriate Medications With Physical Functional Impairments in Older Adults With Cancer.
CONCLUSIONS: Physical function, an important component of outcomes for older adults with cancer, is cross-sectionally associated with polypharmacy (defined as ≥8 medications) and with PIMs. Future studies should evaluate the association of polypharmacy with functional outcomes in this population in a longitudinal fashion. PMID: 33482631 [PubMed - as supplied by publisher] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - January 23, 2021 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Cachexia and Dietetic Interventions in Patients With Esophagogastric Cancer: A Multicenter Cohort Study.
Authors: Dijksterhuis WPM, Latenstein AEJ, van Kleef JJ, Verhoeven RHA, de Vries JHM, Slingerland M, Steenhagen E, Heisterkamp J, Timmermans LM, de van der Schueren MAE, van Oijen MGH, Beijer S, van Laarhoven HWM Abstract BACKGROUND: Cachexia is common in patients with esophagogastric cancer and is associated with increased mortality. Nutritional screening and dietetic interventions can be helpful in preventing evolvement of cachexia. Our aim was to study the real-world prevalence and prognostic value of pretreatment cachexia on overall survival (OS) using patient-reported weight loss, and to explore dietetic inter...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - January 10, 2021 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Longitudinal Analysis of Mental Disorder Burden Among Elderly Patients With Gastrointestinal Malignancies.
CONCLUSIONS: This study suggests a larger role for incorporating psychiatric symptom screening and management throughout oncologic care. PMID: 33401234 [PubMed - as supplied by publisher] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - January 7, 2021 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Body Mass Index and Weight Change in Patients With HER2-Positive Early Breast Cancer: Exploratory Analysis of the ALTTO BIG 2-06 Trial.
This study aimed to determine the impact of body mass index (BMI) at baseline and weight change after 2 years on outcomes of patients with HER2-positive early breast cancer. METHODS: ALTTO was a randomized phase III trial in patients with HER2-positive early breast cancer. BMI was collected at randomization and 2 years after. WHO BMI categories were used: underweight,
Source: Journal of the National Comprehensive Cancer Network : JNCCN - January 7, 2021 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Risk of Cardiovascular Diseases Among Older Breast Cancer Survivors in the United States: A Matched Cohort Study.
CONCLUSIONS: Women with a history of breast cancer were at increased risk of several CVDs, persisting into survivorship. Monitoring and managing cardiovascular risk throughout the long-term follow-up of women diagnosed with breast cancer should be a priority. PMID: 33401236 [PubMed - as supplied by publisher] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - January 7, 2021 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology.
Authors: Daly MB, Pal T, Berry MP, Buys SS, Dickson P, Domchek SM, Elkhanany A, Friedman S, Goggins M, Hutton ML, CGC, Karlan BY, Khan S, Klein C, Kohlmann W, CGC, Kurian AW, Laronga C, Litton JK, Mak JS, LCGC, Menendez CS, Merajver SD, Norquist BS, Offit K, Pederson HJ, Reiser G, CGC, Senter-Jamieson L, CGC, Shannon KM, Shatsky R, Visvanathan K, Weitzel JN, Wick MJ, Wisinski KB, Yurgelun MB, Darlow SD, Dwyer MA Abstract The NCCN Guidelines for Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic focus primarily on assessment of pathogenic or likely pathogenic variants associated with increased ri...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - January 7, 2021 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

NCCN Guidelines Insights: Acute Myeloid Leukemia, Version 2.2021.
Authors: Pollyea DA, Bixby D, Perl A, Bhatt VR, Altman JK, Appelbaum FR, de Lima M, Fathi AT, Foran JM, Gojo I, Hall AC, Jacoby M, Lancet J, Mannis G, Marcucci G, Martin MG, Mims A, Neff J, Nejati R, Olin R, Percival ME, Prebet T, Przespolewski A, Rao D, Ravandi-Kashani F, Shami PJ, Stone RM, Strickland SA, Sweet K, Vachhani P, Wieduwilt M, Gregory KM, Ogba N, Tallman MS Abstract The NCCN Guidelines for Acute Myeloid Leukemia (AML) provide recommendations for the diagnosis and treatment of adults with AML based on clinical trials that have led to significant improvements in treatment, or have yielded new informatio...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - January 7, 2021 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Patterns and Trends of Cancer Screening in Canada: Results From a Contemporary National Survey.
CONCLUSIONS: More than one-third of eligible individuals are missing timely screening tests for CRC. Moreover, at least one-quarter of eligible women are missing their recommended breast and cervical cancer screening tests. More efforts from federal and provincial health authorities are needed to deal with socioeconomic disparities in access to cancer screening. PMID: 33406489 [PubMed - in process] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - January 7, 2021 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

New Persistent Opioid and Benzodiazepine Use After Curative-Intent Treatment in Patients With Breast Cancer.
CONCLUSIONS: A large percentage of patients receiving curative-intent treatment of breast cancer were prescribed new opioids; however, only a small number developed new persistent opioid use. In contrast, a smaller proportion of patients received a new benzodiazepine prescription; however, new persistent use after completion of treatment was more likely and particularly related to concurrent treatment with tamoxifen. PMID: 33406490 [PubMed - in process] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - January 7, 2021 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Letter to the Editor: Clinical Implications of Postoperative Radiotherapy on Patient Survival in Stage IIIA Resected Lung Cancer: More Variables Should Be Considered.
Authors: Chen D, Wang X, Ding Q, Chen Y PMID: 33406491 [PubMed - in process] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - January 7, 2021 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Targeting the NTRK Fusion Gene in Pancreatic Acinar Cell Carcinoma: A Case Report and Review of the Literature.
Authors: Gupta M, Sherrow C, Krone ME, Blais EM, Pishvaian MJ, Petricoin EF, Matrisian LM, DeArbeloa P, Gregory G, Brown A, Zalewski O, Prinzing G, Roche C, Kanehira K, Mukherjee S, Iyer R, Fountzilas C Abstract Pancreatic acinar cell carcinoma (PACC) is a rare pancreatic exocrine malignancy. Compared with the more common pancreatic ductal adenocarcinoma (PDAC), PACC is more common in younger White men, has earlier stages and a lower mean age (56 vs 70 years) at the time of presentation, and has a better prognosis. In addition to differences in demographic, histologic, and clinical characteristics, PACC has a genom...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - January 7, 2021 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Gastrostomy Tube for Nutrition and Malignant Bowel Obstruction in Patients With Cancer.
This study aimed to better understand the risks and benefits associated with the placement and maintenance of G-tubes. METHODS: Patients who underwent placement of a G-tube for cancer from January 2013 through December 2017 at a tertiary care center were considered for inclusion. Clinical data were retrospectively collected from medical records. RESULTS: A total of 242 patients with cancer, whose average age at diagnosis was 61 years (range, 21-94 years), underwent G-tube placement for nutrition (76.4%), decompression (22.7%), or both (0.8%). Successful insertion was achieved in 96.8%, but 8 patients required>1 ...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - January 7, 2021 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Financial Toxicity in Patients With Cancer: What a Tangled Web We Weave.
Authors: Muluneh B PMID: 33406494 [PubMed - in process] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - January 7, 2021 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Impact of Axillary Dissection Among Patients With Sentinel Node-Positive Breast Cancer Undergoing Mastectomy.
CONCLUSIONS: CLND is not significantly correlated with reduced recurrence or improved OS among patients who have cN0, SLN-positive breast cancer treated with mastectomy. CLND was significantly correlated with receipt of adjuvant systemic therapy. Completion of postmastectomy radiotherapy was associated with improved OS. PMID: 33406495 [PubMed - in process] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - January 7, 2021 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

How Have Multigene Panels Changed the Clinical Practice of Genetic Counseling and Testing.
Authors: Pilarski R Abstract Historically, genetic testing (and billing) for hereditary cancer risk was essentially performed gene by gene, with clinicians ordering testing only for the genes most likely to explain a patient's or family's cancer presentation, with laboratories typically charging $1,000 to $1,500 for each gene that was sequenced. Given the expense, only patients at high risk of having a hereditary syndrome were offered testing. With the introduction of next-generation sequencing technologies, however, laboratories are able to test for multiple genes at the same time with greater efficiency, signific...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - January 7, 2021 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

New Year's Resolutions - A Different Perspective.
Authors: Tempero M PMID: 33406497 [PubMed - in process] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - January 7, 2021 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Authors' Reply to Letter to the Editor by Chen et al.
Authors: Gao F, Li N, Xu Y, Yang G PMID: 33406498 [PubMed - in process] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - January 7, 2021 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Opioid and Benzodiazepine Use in Women With Breast Cancer: More Work on the Horizon.
Authors: Cata JP, Kim DD PMID: 33406499 [PubMed - in process] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - January 7, 2021 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Methylene Blue for the Treatment of Intractable Pain From Oral Mucositis Related to Cancer Treatment: An Uncontrolled Cohort.
Authors: Roldan CJ, Chung M, Feng L, Bruera E Abstract BACKGROUND: Oral mucositis is a complication of cancer therapy, causing severe pain that affects oral functioning, nutrition, and quality of life, as well as therapy nonadherence or dose-limiting toxicity. Anecdotal experience has suggested that methylene blue (MB) oral rinse may be an effective and safe treatment of this oral pain. METHODS: To evaluate the efficacy and safety of MB oral rinse for the treatment of oral pain due to mucositis in patients with cancer, we retrospectively evaluated patients who experienced refractory pain despite conventional th...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - January 6, 2021 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Impact of Telemedicine on Patient Satisfaction and Perceptions of Care Quality in Radiation Oncology.
CONCLUSIONS: This study is the first to assess telemedicine in routine radiation oncology practice, and found high patient satisfaction and confidence in their care. Optimization of telemedicine in oncology should be a priority, specifically access to audiovisual capabilities that can improve patient-oncologist communication. PMID: 33395627 [PubMed - as supplied by publisher] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - January 6, 2021 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Genomic Instability and Clonal Evolution in Chronic Lymphocytic Leukemia: Clinical Relevance.
Authors: Condoluci A, Rossi D Abstract Genomic instability and clonal heterogeneity can influence cancer progression, response to therapy, and relapse. Chronic lymphocytic leukemia (CLL) harbors a variety of clones and subclones that will evolve differently according to intrinsic (microenvironment) and extrinsic (therapy) pressures. Different patterns of clonal evolution have been described, providing insights into the CLL leukemic cell, dynamics, selection, and treatment refractoriness. With the help of genomic technologies allowing a granular resolution of CLL clones, novel synergic therapeutic strategies can be ...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - January 2, 2021 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research