Getting What You Pay For: Finding Value in Cancer Care.
Authors: Tempero M PMID: 30181413 [PubMed - in process] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - September 6, 2018 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Letter to the Editor: Significance of Clonal Hematopoiesis of Indeterminate Potential.
Authors: Sorscher S, Usha L, Burgess K, Klapko O, Buckingham L PMID: 30181414 [PubMed - in process] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - September 6, 2018 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Targeting BRAF Mutations in High-Grade Neuroendocrine Carcinoma of the Colon.
This report presents 2 patients with high-grade colorectal NECs who had different responses to treatment with combined BRAF/MEK inhibition after experiencing disease progression through first-line platinum-based chemotherapy. One patient experienced an excellent initial response to therapy before ultimately experiencing progression, and in the other patient initially had stable disease before eventually experiencing progression. These cases highlight the complicated role BRAF mutations play in gastrointestinal NECs, and the need for further research to identify not only patients who may benefit from BRAF-directed therapies...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - September 6, 2018 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

NCCN Guidelines Insights: Bladder Cancer, Version 5.2018.
Authors: Flaig TW, Spiess PE, Agarwal N, Bangs R, Boorjian SA, Buyyounouski MK, Downs TM, Efstathiou JA, Friedlander T, Greenberg RE, Guru KA, Hahn N, Herr HW, Hoimes C, Inman BA, Jimbo M, Kader AK, Lele SM, Meeks JJ, Michalski J, Montgomery JS, Pagliaro LC, Pal SK, Patterson A, Petrylak DP, Plimack ER, Pohar KS, Porter MP, Preston MA, Sexton WJ, Siefker-Radtke AO, Tward J, Wile G, Johnson-Chilla A, Dwyer MA, Gurski LA Abstract The NCCN Clinical Practice Guidelines in Oncology for Bladder Cancer provide recommendations for the diagnosis, evaluation, treatment, and follow-up of patients with bladder cancer. These NC...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - September 6, 2018 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Use of Inpatient Palliative Care Services in Patients With Advanced Cancer Receiving Critical Care Therapies.
This study investigated the use pattern of IPC, outcomes (in-hospital mortality, length of stay [LOS], discharge destination, and cost of care), and predictors of IPC use in patients with metastatic cancer who received CCTs. We hypothesized that IPC services are underused in this cohort. Methods: In this retrospective cohort study, we used the 2010 California State Inpatient Databases to identify adults with metastatic cancer who received CCTs that are common and reliably coded (IMV, tracheostomy, percutaneous endoscopic gastrostomy tube, dialysis for acute kidney failure, and total parenteral nutrition). We determined IPC...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - September 6, 2018 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Ability to Predict New-Onset Psychological Distress Using Routinely Collected Health Data: A Population-Based Cohort Study of Women Diagnosed With Breast Cancer.
Conclusions: This study identified the predictors of new-onset psychological distress available in routinely collected administrative health databases, and showed how predictors change between hospital-based treatment and transitional survivorship periods. The results highlight the importance of developing predictive models tailored to the period of cancer care. PMID: 30181418 [PubMed - in process] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - September 6, 2018 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Benchmarking Cancer Centers: From Care Pathways to Integrated Practice Units.
Conclusions: A benchmark tool for care pathways was successfully developed and tested, and is available in an open format. Our tool allows for the assessment of pathway organization and can be used to assess the status of IPU development. Opportunities for improvement were identified regarding the organization of care pathways and the development toward IPUs. Three centers are in varying degrees of implementation and can be characterized as breast cancer IPUs. Organizing cancer care in an IPU could yield multiple performance improvements. PMID: 30181419 [PubMed - in process] (Source: Journal of the National Comprehensi...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - September 6, 2018 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Impact of Nonconcordance With NCCN Guidelines on Resource Utilization, Cost, and Mortality in De Novo Metastatic Breast Cancer.
Conclusions: Despite a lack of survival benefit, concordant care was associated with lower costs, suggesting potential benefit to increasing standardization of care. These findings may influence policy decisions regarding implementation of pathway programs as health systems transition to value-based models. PMID: 30181420 [PubMed - in process] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - September 6, 2018 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Chimeric Antigen Receptor T-Cell Therapy.
This report describes the current state of CAR T-cell therapy and future strategies that should be considered as the application of this novel immunotherapy expands and evolves. PMID: 30181421 [PubMed - in process] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - September 6, 2018 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Chronic Myeloid Leukemia, Version 1.2019, NCCN Clinical Practice Guidelines in Oncology.
Authors: Radich JP, Deininger M, Abboud CN, Altman JK, Berman E, Bhatia R, Bhatnagar B, Curtin P, DeAngelo DJ, Gotlib J, Hobbs G, Jagasia M, Kantarjian HM, Maness L, Metheny L, Moore JO, Pallera A, Pancari P, Patnaik M, Purev E, Rose MG, Shah NP, Smith BD, Snyder DS, Sweet KL, Talpaz M, Thompson J, Yang DT, Gregory KM, Sundar H Abstract Chronic myeloid leukemia (CML) is defined by the presence of Philadelphia chromosome (Ph), resulting from a reciprocal translocation between chromosomes 9 and 22 [t(9;22] that gives rise to a BCR-ABL1 fusion gene. CML occurs in 3 different phases (chronic, accelerated, and blast pha...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - September 6, 2018 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Management of Primary Ovarian Insufficiency Symptoms in Survivors of Childhood and Adolescent Cancer.
This article systematically reviews the literature on the prevalence, surveillance, and treatment of POI in survivors of pediatric and adolescent and young adult (AYA) cancers. A systematic review of the literature was conducted in January 2018 through a search of Medline, Embase, Web of Science, and SCOPUS, alongside the screening of relevant reference lists. An initial search identified 746 potentially relevant studies. A total of 36 studies were included in the final review. Studies were categorized into one of the following categories: incidence/prevalence of POI, measurement of ovarian reserve, and other. Depending on...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - September 6, 2018 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Resurrection of PARP Inhibitors in Breast Cancer.
Authors: Lyons TG, Robson ME Abstract PARP enzymes are essential for DNA damage repair. Cancers with defective homologous recombination DNA repair, such has BRCA1- and BRCA2-mutated breast cancers, are targets for PARP inhibitors (PARPi) through the exploitation of synthetic lethality. A number of PARPi are currently undergoing clinical evaluation in breast cancer, with olaparib and talazoparib having demonstrated superior efficacy compared with standard chemotherapy in advanced germline BRCA-mutated cancer. This review describes the biological rationale for PARPi and presents the accumulating data on PARPi use in ...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - September 6, 2018 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Being Critical of Critical Care Given to People With Metastatic Cancer: Get Palliative Care Involved.
Authors: Mehmood T, Smith TJ PMID: 30181425 [PubMed - in process] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - September 6, 2018 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Notes From the Other Side.
Authors: Tempero M PMID: 30099366 [PubMed - in process] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - August 14, 2018 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Letter to the Editor: Integrating Skeletal Muscle Mass and Radiodensity Improves Outcome Prediction and Correlation in Oncologic Studies.
Authors: Williams GR, Weinberg MS, Shachar SS, Chaves GV PMID: 30099367 [PubMed - in process] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - August 14, 2018 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Evaluating Antiretroviral Therapy Initiation in HIV-Associated Malignancy: Is There Enough Evidence to Inform Clinical Guidelines?
Authors: Oseso LN, Chiao EY, Ignacio RAB PMID: 30099368 [PubMed - in process] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - August 14, 2018 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

DNA Repair Gene Alterations and PARP Inhibitor Response in Patients With Metastatic Castration-Resistant Prostate Cancer.
Conclusions: Our results demonstrate that not all DNA repair alterations are equally predictive of PARP inhibitor response. Importantly, all responding patients had tumors harboring BRCA2 DNA repair alterations, including one without a known pathogenic mutation. Conversely, among the 4 nonresponders, several DNA repair alterations in genes other than BRCA2 were identified that were not clearly pathogenic. This demonstrates the need to carefully examine the functional relevance of the DNA repair alterations identified, especially in genes other than BRCA2, when considering patients for PARP inhibitor treatment. PMID: 30...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - August 14, 2018 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

NCCN Guidelines Insights: Colorectal Cancer Screening, Version 1.2018.
Authors: Provenzale D, Gupta S, Ahnen DJ, Markowitz AJ, Chung DC, Mayer RJ, Regenbogen SE, Blanco AM, Bray T, Cooper G, Early DS, Ford JM, Giardiello FM, Grady W, Hall MJ, Halverson AL, Hamilton SR, Hampel H, Klapman JB, Larson DW, Lazenby AJ, Llor X, Lynch PM, Mikkelson J, Ness RM, Slavin TP, Sugandha S, Weiss JM, Dwyer MA, Ogba N Abstract The NCCN Guidelines for Colorectal Cancer (CRC) Screening outline various screening modalities as well as recommended screening strategies for individuals at average or increased-risk of developing sporadic CRC. The NCCN panel meets at least annually to review comments from revi...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - August 14, 2018 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Chemoradiation Improves Survival Compared With Chemotherapy Alone in Unresected Nonmetastatic Gastric Cancer.
Authors: Li R, Hou WH, Chao J, Woo Y, Glaser S, Amini A, Nelson RA, Chen YJ Abstract Background: Limited data are available to guide management of patients with stage I-III gastric cancer not undergoing potentially curative surgical resection. We compared survival outcomes associated with chemotherapy alone versus chemoradiation (CRT) in the treatment of nonmetastatic gastric cancer. Methods: Patients with gastric adenocarcinoma from 2004 to 2015 were identified using the National Cancer Database. Patients were excluded if they had surgery, metastatic disease, or T0, Tis, or T1a disease. Logistic regression was use...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - August 14, 2018 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Swedish Version of the Distress Thermometer: Validity Evidence in Patients With Colorectal Cancer.
The objective of this study was to validate the NCCN Distress Thermometer (DT), including the accompanying Problem List (PL), in a Swedish population of patients diagnosed with colorectal cancer (CRC). Methods: A total of 488 patients diagnosed with CRC completed the DT/PL and EORTC core quality-of-life questionnaire (QLQ-C30) before surgery. Construct validity of the PL was analyzed using a confirmatory factor analysis. Internal consistency reliability (ICR) was tested using Cronbach's alpha coefficient. Correlations between the reported PL areas and QLQ-C30 function scales were used to explore convergent validity. Discri...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - August 14, 2018 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Genomic Profiling in Patients With Malignant Peripheral Nerve Sheath Tumors Reveals Multiple Pathways With Targetable Mutations.
Conclusions: All MPNSTs would benefit from a comprehensive genomic analysis. Treatments targeted to RAS/RAF, DNA repair, and CDKN2A/B pathways should be used and/or developed to treat this uncommon tumor. PMID: 30099373 [PubMed - in process] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - August 14, 2018 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Determinants and Outcomes of Satisfaction With Healthcare Provider Communication Among Cancer Survivors.
Conclusions: We identified potential differences in cancer survivors' needs and expectations of provider communication based on comorbidities and baseline service use. These results emphasize the need for individualized communication strategies for patients with cancer and survivors shaped by their distinct requirements. Our findings of better health, lower service use, and lower expenditures among more satisfied cancer survivors suggest that interventions to improve provider communication could lead to a more efficient use of healthcare resources. PMID: 30099374 [PubMed - in process] (Source: Journal of the National C...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - August 14, 2018 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Cancer in People Living With HIV, Version 1.2018, NCCN Clinical Practice Guidelines in Oncology.
Authors: Reid E, Suneja G, Ambinder RF, Ard K, Baiocchi R, Barta SK, Carchman E, Cohen A, Gupta N, Johung KL, Klopp A, LaCasce AS, Lin C, Makarova-Rusher OV, Mehta A, Menon MP, Morgan D, Nathwani N, Noy A, Palella F, Ratner L, Rizza S, Rudek MA, Taylor J, Tomlinson B, Wang CJ, Dwyer MA, Freedman-Cass DA Abstract People living with HIV (PLWH) are diagnosed with cancer at an increased rate over the general population and generally have a higher mortality due to delayed diagnoses, advanced cancer stage, comorbidities, immunosuppression, and cancer treatment disparities. Lack of guidelines and provider education has le...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - August 14, 2018 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Evolving Paradigms in HIV Malignancies: Review of Ongoing Clinical Trials.
Authors: Ignacio RAB, Lin LL, Rajdev L, Chiao E Abstract This review highlights current interventional clinical trials for HIV-associated malignancies (HIVAMs), with emphasis on 4 mechanistic areas: immunomodulatory therapies and gene therapies, including immune checkpoint inhibitors; cytotoxic therapies; novel tumor-targeted and virally targeted therapies in both AIDS-defining and non-AIDS-defining cancers (NADC); and other screening or topical/ablative interventions. A search on ClinicalTrials.gov located 35 trials, including 12 immunomodulatory or gene therapy trials, 6 cytotoxic therapy trials, 10 trials of the...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - August 14, 2018 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Does Chemoradiation Benefit Patients With Gastric Cancer Managed Without Surgery?
Authors: Johung KL, Stein SM PMID: 30099377 [PubMed - in process] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - August 14, 2018 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Genomic Medicine Takes the Stage, Again!
Authors: Tempero M PMID: 30006420 [PubMed - in process] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - July 15, 2018 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Response to Checkpoint Inhibitor Therapy in Advanced Classic Kaposi Sarcoma: A Case Report and Immunogenomic Study.
We report a case of advanced classic KS refractory to multiple lines of chemotherapy that experienced a partial response to anti-PD-1 therapy. Comprehensive molecular profiling was performed on a diagnostic tumor biopsy sample. Molecular profiling data from 8 additional male patients with KS were reviewed and compared with those of the index case. The genomic profile of the index case was notable for higher-than-typical somatic mutational burden, including pathogenic mutation in multiple well-described cancer genes, such as TP53, CDKN2A, NOTCH1, and KRAS Our case suggests that further clinical study of checkpoint inhibitor...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - July 15, 2018 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Addressing Survivorship in Cancer Care.
This article encapsulates the findings of the thorough environmental scan and the discussion from the NCCN Patient Advocacy Summit, including identified gaps and needs in addressing survivorship in cancer care. PMID: 30006422 [PubMed - in process] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - July 15, 2018 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

NCCN Guidelines Insights: Non-Small Cell Lung Cancer, Version 5.2018.
Authors: Ettinger DS, Aisner DL, Wood DE, Akerley W, Bauman J, Chang JY, Chirieac LR, D'Amico TA, Dilling TJ, Dobelbower M, Govindan R, Gubens MA, Hennon M, Horn L, Lackner RP, Lanuti M, Leal TA, Lilenbaum R, Lin J, Loo BW, Martins R, Otterson GA, Patel SP, Reckamp K, Riely GJ, Schild SE, Shapiro TA, Stevenson J, Swanson SJ, Tauer K, Yang SC, Gregory K, Hughes M Abstract The NCCN Guidelines for Non-Small Cell Lung Cancer (NSCLC) address all aspects of management for NSCLC. These NCCN Guidelines Insights focus on recent updates to the targeted therapy and immunotherapy sections in the NCCN Guidelines. For the 2018 u...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - July 15, 2018 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Evaluation of a Completion Total Mesorectal Excision in Patients After Local Excision of Rectal Cancer: A Word of Caution.
This study evaluated cTME after local excision at a national level with possible determinants for decision-making. Methods: All patients in the Dutch Colorectal Audit (DCRA) who underwent local excision of rectal cancer between 2012 and 2015 were included. Guideline adherence for performing cTME was determined with univariate and multivariate analyses to identify factors related to noncompliance. Results: According to the guidelines, of 530 included patients, cTME was indicated in 283 (53%), and among those, was performed in 82 (29%). Guideline adherence for performing cTME improved significantly (P
Source: Journal of the National Comprehensive Cancer Network : JNCCN - July 15, 2018 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Geographic Variation in Postoperative Imaging for Low-Risk Breast Cancer.
Conclusions: In patients with breast cancer treated for low-risk disease, geography has effects on the rates of posttreatment imaging, suggesting that some patients are not receiving beneficial dedicated breast imaging, and high-cost nonbreast imaging may not be targeted to those groups most likely to benefit. PMID: 30006425 [PubMed - in process] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - July 15, 2018 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Searching for Survivor-Specific Services at NCI-Designated Comprehensive Cancer Centers: A Qualitative Assessment.
Conclusions: The CCCs have an opportunity to serve as information hubs and to lessen the amount of work associated with survivorship. As models of cancer care delivery, the CCCs can also set the standard for community oncologists and clinics for delivery of care that improves the quality of life for survivors. PMID: 30006426 [PubMed - in process] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - July 15, 2018 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Outcomes Following Neoadjuvant Chemotherapy for Breast Cancer in Women Aged 40 Years and Younger: Impact of Pathologic Nodal Response.
Authors: Kozak MM, Jacobson CE, von Eyben R, Pollom EL, Telli M, Horst KC Abstract Purpose: We sought to evaluate whether pathologic nodal response was predictive of outcomes in women aged ≤40 years with breast cancer treated with neoadjuvant chemotherapy (NAC). Methods: A total of 220 patients treated with NAC between 1991 and 2015 were retrospectively reviewed. Pathologic complete response (pCR) was defined as no evidence of residual invasive tumor in the breast and lymph nodes (LNs) (ypT0/Tis ypN0); partial response if there was no tumor in the LNs but residual tumor in the breast (ypT+ ypN0) or residual tumo...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - July 15, 2018 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Anal Carcinoma, Version 2.2018, NCCN Clinical Practice Guidelines in Oncology.
Authors: Benson AB, Venook AP, Al-Hawary MM, Cederquist L, Chen YJ, Ciombor KK, Cohen S, Cooper HS, Deming D, Engstrom PF, Grem JL, Grothey A, Hochster HS, Hoffe S, Hunt S, Kamel A, Kirilcuk N, Krishnamurthi S, Messersmith WA, Meyerhardt J, Mulcahy MF, Murphy JD, Nurkin S, Saltz L, Sharma S, Shibata D, Skibber JM, Sofocleous CT, Stoffel EM, Stotsky-Himelfarb E, Willett CG, Wuthrick E, Gregory KM, Freedman-Cass DA Abstract The NCCN Guidelines for Anal Carcinoma provide recommendations for the management of patients with squamous cell carcinoma of the anal canal or perianal region. Primary treatment of anal cancer us...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - July 15, 2018 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Rectal Cancer, Version 2.2018, NCCN Clinical Practice Guidelines in Oncology.
Authors: Benson AB, Venook AP, Al-Hawary MM, Cederquist L, Chen YJ, Ciombor KK, Cohen S, Cooper HS, Deming D, Engstrom PF, Grem JL, Grothey A, Hochster HS, Hoffe S, Hunt S, Kamel A, Kirilcuk N, Krishnamurthi S, Messersmith WA, Meyerhardt J, Mulcahy MF, Murphy JD, Nurkin S, Saltz L, Sharma S, Shibata D, Skibber JM, Sofocleous CT, Stoffel EM, Stotsky-Himelfarb E, Willett CG, Wuthrick E, Gregory KM, Gurski L, Freedman-Cass DA Abstract The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Rectal Cancer address diagnosis, staging, surgical management, perioperative treatment, management of recurrent an...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - July 15, 2018 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Role of Immunotherapy in the Treatment of Squamous Cell Carcinoma of the Anal Canal.
This article reviews the early successes of anti-PD-1 therapies and adoptive T-cell therapies for metastatic anal cancer as a potential foundation for novel combination immunotherapy trials in the future. PMID: 30006430 [PubMed - in process] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - July 15, 2018 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Evolving Treatment Paradigm in the Treatment of Locally Advanced Rectal Cancer.
Authors: Smith CA, Kachnic LA Abstract Locally advanced rectal cancer (LARC) carries higher risks of local and distant recurrence when treated with surgical resection alone. Multiple treatment strategies have been investigated to reduce recurrence risk and improve survival. Currently, there are 3 primary strategies for managing LARC: (1) preoperative long-course radiotherapy (RT) combined with radiosensitizing chemotherapy, which is better tolerated than postoperative chemoradiotherapy and provides tumor downstaging and improved pathologic complete response (pCR), followed by postoperative chemotherapy; (2) preoper...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - July 15, 2018 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Appropriate Use of Imaging to Detect Primary, Second Primary, and Recurrent Breast Cancer.
Authors: Niell BL PMID: 30006432 [PubMed - in process] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - July 15, 2018 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Movin' On Up!
Authors: Tempero M PMID: 29891517 [PubMed - in process] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - June 14, 2018 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Integrated Histogenetic Analysis Reveals BAP1-Mutated Epithelioid Mesothelioma in a Patient With Cancer of Unknown Primary.
Authors: Bochtler T, Endris V, Reiling A, Leichsenring J, Schweiger MR, Klein S, Stögbauer F, Goeppert B, Schirmacher P, Krämer A, Stenzinger A Abstract This case report presents a male patient with epithelioid mesothelioma that was initially misdiagnosed as cancer of unknown primary (CUP) and correctly identified using molecular panel sequencing. The patient had a prior history of colon and breast cancer. To assess the enlarged mediastinal lymph nodes, retrosternal lymphadenectomy was performed in 2016. The lymph nodes were histologically deemed unrelated to the known breast cancer by the reference patho...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - June 14, 2018 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Metachronous Medulloblastoma in a Child With Successfully Treated Neuroblastoma: Case Report and Novel Findings of DNA Sequencing.
This report presents the clinical case of a 23-month-old child who was diagnosed with an anaplastic medulloblastoma 5 months after completing treatment for stage IV neuroblastoma. The patient was treated with complete surgical resection and adjuvant chemoradiation followed by maintenance chemotherapy at an outside institution and came to our institution for further management. A pathologic diagnosis and review of both the suprarenal and posterior fossa masses were performed, as well as a genetic analysis of both cerebellar tumor tissue and blood using next-generation gene sequencing. At our institution, the patient was sub...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - June 14, 2018 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

NCCN Guidelines Insights: Neuroendocrine and Adrenal Tumors, Version 2.2018.
Authors: Shah MH, Goldner WS, Halfdanarson TR, Bergsland E, Berlin JD, Halperin D, Chan J, Kulke MH, Benson AB, Blaszkowsky LS, Eads J, Engstrom PF, Fanta P, Giordano T, He J, Heslin MJ, Kalemkerian GP, Kandeel F, Khan SA, Kidwai WZ, Kunz PL, Kuvshinoff BW, Lieu C, Pillarisetty VG, Saltz L, Sosa JA, Strosberg JR, Sussman CA, Trikalinos NA, Uboha NA, Whisenant J, Wong T, Yao JC, Burns JL, Ogba N, Zuccarino-Catania G Abstract The NCCN Guidelines for Neuroendocrine and Adrenal Tumors provide recommendations for the management of adult patients with neuroendocrine tumors (NETs), adrenal gland tumors, pheochromocytomas,...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - June 14, 2018 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Receipt of Guideline-Concordant Care Among Older Women With Stage I-III Breast Cancer: A Population-Based Study.
Conclusions: Fewer than half of older women with breast cancer received GCC, with the lowest rates observed among the oldest age groups, racial/ethnic minorities, and women with later-stage cancers. However, patients with more aggressive tumor characteristics and greater access to oncology resources were more likely to receive GCC. Considering that older women have the highest incidence of breast cancer and that many are diagnosed at stages requiring more aggressive treatment, efforts to increase rates of earlier stage diagnosis and the development of less toxic treatments could help improve GCC and survival while preservi...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - June 14, 2018 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Clinical Impact of Local Progression in Pancreatic Cancer.
This study aimed to define the complications and hospitalizations from local versus distant disease progression among a retrospective cohort of patients with pancreatic cancer. Methods: Records of 298 cases of pancreatic cancer treated at a single institution from 2004 through 2015 were retrospectively reviewed, and cancer-related symptoms and complications requiring hospitalization were recorded. Hospitalizations related to pancreatic cancer were attributed to either local or distant progression. Cumulative incidence analyses were used to estimate the incidence of hospitalization, and multivariable Fine-Gray regression mo...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - June 14, 2018 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Outcomes From a Patient-Centered, Interprofessional, Palliative Consult Team in Oncology.
Conclusions: Patients who completed this interdisciplinary palliative consult service appeared to experience a reduction in their most severe symptoms. Visits to patients during existing appointments or having them attend a half-day clinic appears to have reached those referred. With interdisciplinary integration, clinicians are able to collaborate to address patient care needs. Considerations include how to further integrate palliative and psychosocial care to achieve additional benefits and ongoing monitoring of changes in symptom burden. PMID: 29891523 [PubMed - in process] (Source: Journal of the National Comprehen...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - June 14, 2018 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Early Versus Delayed Initiation of Salvage Androgen Deprivation Therapy and Risk of Prostate Cancer-Specific Mortality.
This study sought to ascertain whether there is an association between prostate cancer (PC)-specific mortality (PCSM) and timing of salvage androgen deprivation therapy (ADT) among men with short versus long prostate-specific antigen doubling times (PSA-DTs). Methods: The study cohort was selected from 206 men with localized unfavorable-risk PC randomized to radiation therapy (RT) or RT plus 6 months of ADT between 1995 and 2001. A total of 54 men who received salvage ADT for PSA failure after a median follow-up of 18.72 years following randomization defined the study cohort. The Fine-Gray competing risks regression model ...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - June 14, 2018 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Weekend Effect in Emergency Colon and Rectal Cancer Surgery: A Prospective Study Using Data From the Dutch ColoRectal Audit.
Conclusions: Weekend emergency colon cancer surgery was associated with higher mortality and severe complication rates. More research is needed to understand which factors explain and contribute to these differences. PMID: 29891525 [PubMed - in process] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - June 14, 2018 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Merkel Cell Carcinoma, Version 1.2018, NCCN Clinical Practice Guidelines in Oncology.
Authors: Bichakjian CK, Olencki T, Aasi SZ, Alam M, Andersen JS, Blitzblau R, Bowen GM, Contreras CM, Daniels GA, Decker R, Farma JM, Fisher K, Gastman B, Ghosh K, Grekin RC, Grossman K, Ho AL, Lewis KD, Loss M, Lydiatt DD, Messina J, Nehal KS, Nghiem P, Puzanov I, Schmults CD, Shaha AR, Thomas V, Xu YG, Zic JA, Hoffmann KG, Engh AM Abstract This selection from the NCCN Guidelines for Merkel Cell Carcinoma (MCC) focuses on areas impacted by recently emerging data, including sections describing MCC risk factors, diagnosis, workup, follow-up, and management of advanced disease with radiation and systemic therapy. Inc...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - June 14, 2018 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Radiotherapy in the Multidisciplinary Management of Merkel Cell Carcinoma.
This article discusses the indications, treatment considerations, and recommended dose prescriptions for RT in the management of early- and advanced-stage disease. Considerable hope exists that immunotherapy advances will synergize with RT to further enhance clinical outcomes. PMID: 29891527 [PubMed - in process] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - June 14, 2018 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Advances in Immunotherapy for Metastatic Merkel Cell Carcinoma: A Clinician's Guide.
This article reviews the safety and efficacy data from the key clinical trials of immune checkpoint inhibitors for metastatic MCC, and discusses several issues relevant to the clinical use of these agents. Finally, emerging immunotherapies for MCC, including cellular therapies and adjuvant systemic therapies, are reviewed. PMID: 29891528 [PubMed - in process] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - June 14, 2018 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research