Central Nervous System Cancers, Version 3.2020, NCCN Clinical Practice Guidelines in Oncology.
This article describes NCCN Guidelines recommendations for WHO grade I, II, III, and IV gliomas. Treatment of brain metastases, the most common intracranial tumors in adults, is also described. PMID: 33152694 [PubMed - in process] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - November 7, 2020 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Prostate Cancer Grade and Stage Misclassification in Active Surveillance Candidates: Black Versus White Patients.
This study aimed to address this void. METHODS: Within the SEER database (2010-2015), we focused on patients with very low, low, and favorable intermediate risk for prostate cancer who underwent radical prostatectomy and had available stage and grade information. Descriptive analyses, temporal trend analyses, and multivariate logistic regression analyses were used. RESULTS: Overall, 4,704 patients with very low risk (701 Black vs 4,003 White), 17,785 with low risk (2,696 Black vs 15,089 White), and 11,040 with favorable intermediate risk (1,693 Black vs 9,347 White) were identified. Rates of upgrading and/or upstag...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - November 7, 2020 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Validating a Patient-Reported Outcomes-Derived Algorithm for Classifying Symptom Complexity Levels Among Patients With Cancer.
CONCLUSIONS: The validity of the PRO-derived symptom complexity algorithm is established in this study. The algorithm demonstrated satisfactory accuracy against a clinician-driven complexity assessment and a strong correlation with the known group analysis. Furthermore, the algorithm showed a higher screening capacity compared with the algorithm generated from 2-step cluster analysis, reinforcing the importance of contextualization when classifying patients' symptoms, rather than purely relying on statistical outcomes. The algorithm carries importance in clinical settings, acting as a symptom complexity flag, helping healt...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - November 7, 2020 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Lessons From Adaptive Randomization: Spying the I-SPY2 Trial in Breast Cancer.
Authors: Gyawali B, Niraula S PMID: 33152697 [PubMed - in process] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - November 7, 2020 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

A New Surveillance Algorithm After Resection of Colorectal Liver Metastases Based on Changes in Recurrence Risk and RAS Mutation Status.
Authors: Kawaguchi Y, Kopetz S, Lillemoe HA, Hwang H, Wang X, Tzeng CD, Chun YS, Aloia TA, Vauthey JN Abstract BACKGROUND: The optimal surveillance strategy after resection of colorectal liver metastases (CLM) is unknown. We evaluated changes in recurrence risk after CLM resection and developed a surveillance algorithm. METHODS: Patients undergoing CLM resection during 1998 to 2015 were identified from a prospectively compiled database and analyzed if they had the potential for follow-up longer than the longest observed time to recurrence in this cohort. Changes in recurrence risk and risk factors for recurrenc...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - November 7, 2020 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

The Internet as a Route to Health Information, Support, and Healthcare for Cancer Survivors.
Authors: Bender JL PMID: 33152699 [PubMed - in process] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - November 7, 2020 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Challenges in the Treatment of Newly Diagnosed and Recurrent Primary Central Nervous System Lymphoma.
This article aims to provide a clinically practical approach to PCNSL, including special considerations for older patients and those with impaired renal function. The benefits and risks of HD-MTX or high-dose chemotherapy with autologous stem cell transplantation versus other, better tolerated strategies are also discussed. In all settings, the preferred treatment is always enrollment in a clinical trial if one is available. PMID: 33152700 [PubMed - in process] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - November 7, 2020 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Molecular Insights in Transmission of Cancer From an Organ Donor to Four Transplant Recipients.
We describe the detection of a gastrointestinal adenocarcinoma transmitted from a young donor to 4 transplant recipients. Multidimensional histopathologic and genomic profiling showed a CDH1 mutation and MET amplification, consistent with gastric origin. At the time of writing, one patient in this series remains alive and without evidence of cancer after prompt organ explant after cancer was reported in other recipients. Because identification of a donor-derived malignancy changes management, our recommendation is to routinely perform short tandem repeat testing (or a comparable assay) immediately upon diagnosis of cancer ...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - November 7, 2020 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Lasting Effects of COVID-19: Reimbursement Reform?
Authors: Tempero M PMID: 33152702 [PubMed - in process] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - November 7, 2020 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

NCCN Guidelines Insights: T-Cell Lymphomas, Version 1.2021.
Authors: Horwitz SM, Ansell S, Ai WZ, Barnes J, Barta SK, Clemens MW, Dogan A, Goodman AM, Goyal G, Guitart J, Halwani A, Haverkos BM, Hoppe RT, Jacobsen E, Jagadeesh D, Jones A, Kim YH, Mehta-Shah N, Olsen EA, Pro B, Rajguru SA, Rozati S, Said J, Shaver A, Shustov A, Sokol L, Torka P, Torres-Cabala C, Wilcox R, William BM, Zain J, Dwyer MA, Sundar H Abstract Hepatosplenic T-cell lymphoma (HSTCL) is a rare subtype of T-cell lymphoma associated with an aggressive clinical course and a worse prognosis. HSTCL develops in the setting of chronic immune suppression or immune dysregulation in up to 20% of cases and is mos...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - November 7, 2020 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Use of 18F-FDG PET/CT as an Initial Staging Procedure for Stage II-III Breast Cancer: A Multicenter Value Analysis.
Authors: Hyland CJ, Varghese F, Yau C, Beckwith H, Khoury K, Varnado W, Hirst GL, Flavell RR, Chien AJ, Yee D, Isaacs CJ, Forero-Torres A, Esserman LJ, Melisko ME Abstract BACKGROUND: Metastatic staging imaging is not recommended for asymptomatic patients with stage I-II breast cancer. Greater distant metastatic disease risk may warrant baseline imaging in patients with stage II-III with high-risk biologic subtypes. NCCN Guidelines recommend considering CT of the chest, abdomen, and pelvis (CT CAP) and bone scan in appropriate patients. CT CAP and bone scan are considered standard of care (SoC), although PET/CT is ...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - November 7, 2020 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Role of Postoperative Radiotherapy in Nonmetastatic Head and Neck Adenoid Cystic Carcinoma.
This study aimed to assess the role of PORT and provide individualized suggestions for postoperative therapy in patients with ACC. PATIENTS AND METHODS: We retrospectively reviewed patients with nonmetastatic head and neck ACC who underwent surgery with or without PORT. Recursive partitioning analysis (RPA) was performed to categorize the patients and predict local recurrence-free survival (LRFS). The survival outcome was compared between non-PORT and PORT groups. RESULTS: A total of 319 patients were included. PORT was identified as a prognostic factor for LRFS in univariate (P=.01) and multivariate analysis (P
Source: Journal of the National Comprehensive Cancer Network : JNCCN - November 7, 2020 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Proposed Additions to the NCCN Guidelines for Adult Medulloblastoma.
Authors: Penas-Prado M, Armstrong TS, Gilbert MR Abstract Medulloblastoma is a rare brain tumor that occurs in both children and adults, with patients aged 15 to 39 years accounting for 30% of all cases. In adults, guidelines for diagnosis and treatment are often based on retrospective data and extrapolated from the pediatric experience due to limited availability of prospective trials or registries involving adults. Importantly, adult patients differ from pediatric patients in many aspects, including the molecular features of the tumor and tolerance to treatment. In 2017, the NCI was granted support from the Cance...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - November 7, 2020 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

General and Health-Related Internet Use Among Cancer Survivors in the United States: A 2013-2018 Cross-Sectional Analysis.
Authors: Dee EC, Muralidhar V, Butler SS, Yu Z, Sha ST, Mahal BA, Nguyen PL, Sanford NN Abstract BACKGROUND: A significant proportion of cancer survivors endorse ongoing health information needs and may use the internet to access information. We assessed patterns and predictors of general and health-specific internet use among cancer survivors. METHODS: Using data from the National Health Interview Survey (NHIS), which was administered in 2013 through 2018, for adults reporting a cancer diagnosis, sample weight-adjusted estimates defined prevalence and multivariable logistic regressions defined adjusted odds ra...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - November 7, 2020 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Cost-Effectiveness of Maintenance Olaparib for Germline BRCA-Mutated Metastatic Pancreatic Cancer.
CONCLUSIONS: Maintenance olaparib is potentially cost-effective compared with placebo for patients with a germline BRCA mutation and MPC. Economic outcomes could be improved by tailoring treatment based on individual patient factors. PMID: 33152708 [PubMed - in process] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - November 7, 2020 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Outcomes of COVID-19 in Patients With a History of Cancer and Comorbid Cardiovascular Disease.
Authors: Ganatra S, Dani SS, Redd R, Rieger-Christ K, Patel R, Parikh R, Asnani A, Bang V, Shreyder K, Brar SS, Singh A, Kazi DS, Guha A, Hayek SS, Barac A, Gunturu KS, Zarwan C, Mosenthal AC, Yunus SA, Kumar A, Patel JM, Patten RD, Venesy DM, Shah SP, Resnic FS, Nohria A, Baron SJ Abstract BACKGROUND: Cancer and cardiovascular disease (CVD) are independently associated with adverse outcomes in patients with COVID-19. However, outcomes in patients with COVID-19 with both cancer and comorbid CVD are unknown. METHODS: This retrospective study included 2,476 patients who tested positive for SARS-CoV-2 at 4 Massach...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - November 4, 2020 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Creative Strategies Implemented During the Coronavirus Pandemic That Will Impact the Future of Cancer Care.
Authors: Sugalski J, Franco T, Shulman LN, Cinar P, Bachman J, Crews JR, Olsen M, Schatz A, Kubal T Abstract The coronavirus pandemic has significantly impacted operations at leading cancer centers across the United States. In the midst of the chaos, at least one silver lining has emerged: the development of new, creative strategies for delivering cancer care that are likely to continue post pandemic. The NCCN Best Practices Committee, which is composed of senior physician, nursing, and administrative leaders at NCCN Member Institutions, conducted a webinar series in June 2020 highlighting the most promising and ef...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - November 1, 2020 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Novel Agents for Metastatic Triple-Negative Breast Cancer: Finding the Positive in the Negative.
Authors: Vidula N, Ellisen LW, Bardia A Abstract Metastatic triple-negative breast cancer (TNBC) is associated with a poor prognosis, and the development of better therapeutics represents a major unmet clinical need. Although the mainstay of treatment of metastatic TNBC is chemotherapy, advances in genomics and molecular profiling have helped better define subtypes of TNBC with distinct biologic drivers to guide the therapeutic development of targeted therapies, including AKT inhibitors for PI3K/AKT-altered TNBC, checkpoint inhibitors for PD-L1-positive TNBC, and PARP inhibitors for BRCA1/2 mutant TNBC. This progre...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - October 22, 2020 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Experience, Perceptions, and Recommendations Concerning COVID-19-Related Clinical Research Adjustments.
CONCLUSIONS: Clinical research professionals perceive that COVID-19-related clinical trial adjustments positively impact multiple aspects of study conduct. Those with greatest experience-both specific to COVID-19-related changes and more generally-are more likely to recommend that these adjustments continue in the future. PMID: 33027755 [PubMed - as supplied by publisher] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - October 9, 2020 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

A Cryptic BCR-PDGFRB Fusion Resulting in a Chronic Myeloid Neoplasm With Monocytosis and Eosinophilia: A Novel Finding With Treatment Implications.
Authors: Gupta SK, Jain N, Tang G, Futreal A, Wang SA, Khoury JD, Yang RK, Fang H, Patel KP, Luthra R, Routbort M, Barkoh BA, Chen W, Mao X, Zhang J, Medeiros LJ, Bueso-Ramos CE, Loghavi S Abstract RNA-seq was used to identify the partner gene and confirm the presence of a BCR-PDGFRB fusion. Identification of this fusion product resulted in successful treatment and long-term remission of this myeloid neoplasm. Based on our results, we suggest that despite current WHO recommendations, screening for PDGFRB rearrangement in cases of leukocytosis with eosinophilia and no other etiologic explanation is necessary, even i...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - October 8, 2020 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

NCCN Guidelines Insights: Colorectal Cancer Screening, Version 2.2020.
Authors: Provenzale D, Ness RM, Llor X, Weiss JM, Abbadessa B, Cooper G, Early DS, Friedman M, Giardiello FM, Glaser K, Gurudu S, Halverson AL, Issaka R, Jain R, Kanth P, Kidambi T, Lazenby AJ, Maguire L, Markowitz AJ, May FP, Mayer RJ, Mehta S, Patel S, Peter S, P Stanich P, Terdiman J, Keller J, Dwyer MA, Ogba N Abstract The NCCN Guidelines for Colorectal Cancer (CRC) Screening describe various colorectal screening modalities as well as recommended screening schedules for patients at average or increased risk of developing sporadic CRC. They are intended to aid physicians with clinical decision-making regarding C...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - October 8, 2020 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Performance Status Restriction in Phase III Cancer Clinical Trials.
Authors: Abi Jaoude J, Kouzy R, Mainwaring W, Lin TA, Miller AB, Jethanandani A, Espinoza AF, Pasalic D, Verma V, VanderWalde NA, Smith BD, Smith GL, Fuller CD, Das P, Minsky BD, Rödel C, Fokas E, Jagsi R, Thomas CR, Subbiah IM, Taniguchi CM, Ludmir EB Abstract BACKGROUND: Patients with good performance status (PS) tend to be favored in randomized clinical trials (RCTs), possibly limiting the generalizability of trial findings. We aimed to characterize trial-related factors associated with the use of PS eligibility criteria and analyze patient accrual breakdown by PS. METHODS: Adult, therapeutic, multiarm ...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - October 8, 2020 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Small Renal Masses With Tumor Size 0 to 2 cm: A SEER-Based Study and Validation of NCCN Guidelines.
CONCLUSIONS: Most T1a 0- to 2-cm renal cell carcinoma represents the low-grade clear-cell or low-grade papillary histologic subtype, with an FG3-4 minority. Even in patients with the FG3-4 histologic subtype, rates of synchronous metastases are virtually zero. PMID: 33022641 [PubMed - in process] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - October 8, 2020 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Analysis of Sentinel Node Biopsy and Clinicopathologic Features as Prognostic Factors in Patients With Atypical Melanocytic Tumors.
CONCLUSIONS: Age>20 years, mitotic rate>4/mm2, mitoses at the base of the lesion, lymphovascular invasion, and 9p21 loss proved to be worse prognostic factors in patients with ATMs. Sentinel node status was not a clear prognostic predictor. PMID: 33022642 [PubMed - in process] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - October 8, 2020 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Relationship Between Quality of Life and Survival in Patients With Pancreatic and Periampullary Cancer: A Multicenter Cohort Analysis.
This study analyzed QoL data from a prospective multicenter patient-reported outcome registry in patients with pancreatic or periampullary carcinoma registered in the nationwide Netherlands Cancer Registry (2015-2018). Baseline and delta QoL, between baseline and 3-month follow-up, were assessed with the Happiness, EORTC Quality of Life Questionnaire-Core 30 (QLQ-C30), and QLQ-PAN26 questionnaires. The relationship between QoL and survival was assessed using Cox regression models, and additional prognostic value of separate items was assessed using Nagelkerke R2 (explained variance). RESULTS: For the baseline and delta...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - October 8, 2020 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Chronic Myeloid Leukemia, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology.
Authors: Deininger MW, Shah NP, Altman JK, Berman E, Bhatia R, Bhatnagar B, DeAngelo DJ, Gotlib J, Hobbs G, Maness L, Mead M, Metheny L, Mohan S, Moore JO, Naqvi K, Oehler V, Pallera AM, Patnaik M, Pratz K, Pusic I, Rose MG, Smith BD, Snyder DS, Sweet KL, Talpaz M, Thompson J, Yang DT, Gregory KM, Sundar H Abstract Chronic myeloid leukemia (CML) is defined by the presence of Philadelphia chromosome (Ph) which results from a reciprocal translocation between chromosomes 9 and 22 [t(9;22] that gives rise to a BCR-ABL1 fusion gene. CML occurs in 3 different phases (chronic, accelerated, and blast phase) and is usually ...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - October 8, 2020 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Flirting With Disaster: COVID-19 and Cancer.
Authors: Tempero M PMID: 33022645 [PubMed - in process] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - October 8, 2020 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

A Pilot Study of a Comprehensive Financial Navigation Program in Patients With Cancer and Caregivers.
CONCLUSIONS: Patient-caregiver dyads were willing to participate in a financial navigation program that addresses various financial issues, particularly cost of living expenses in lower income participants. Future work should address financial concerns at diagnosis and determine whether doing so improves patient and caregiver outcomes. PMID: 33022646 [PubMed - in process] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - October 8, 2020 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

The Home is the New Cancer Center.
Authors: Handley NR, Bekelman JE, Binder AF PMID: 33022647 [PubMed - in process] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - October 8, 2020 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Association Between Clinical Value and Financial Cost of Cancer Treatments: A Cross-Sectional Analysis.
CONCLUSIONS: An association between NCCN EB measures and treatment cost was inconsistent, and the magnitude of the association was small compared with the degree of cost variation among treatments with the same EB scores. The clinical value of cancer treatments does not seem to be a primary determinant of treatment cost. PMID: 33022648 [PubMed - in process] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - October 8, 2020 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Contemporary Population-Based Analysis of Bone Mineral Density Testing in Men Initiating Androgen Deprivation Therapy for Prostate Cancer.
The objective of this study was to examine the proportion of BMD testing in men initiating ADT in Quebec and to identify factors associated with receipt of this testing. METHODS: The study cohort consisted of men extracted from Quebec public healthcare insurance administrative databases who initiated continuous ADT from 2000 to 2015 for>12 months. The primary study outcome was receipt of BMD testing in the period from 6 months before through 12 months after ADT initiation. Multivariable generalized linear mixed regression modeling with a logit link was performed to identify variables associated with BMD testing. ...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - October 8, 2020 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Treatment Outcomes in Chronic Myeloid Leukemia: Does One Size Fit All?
Authors: Garcia-Horton A, Lipton JH Abstract With the success of tyrosine kinase inhibitors (TKIs) in achieving next-to-normal overall survival in chronic myeloid leukemia (CML), treatment-free remission (TFR) has become a significant goal in the management of this disease. Discontinuation of therapy is attractive to both patients and physicians because maintaining a stable BCR-ABL transcript level without therapy would imply true operational CML cure. With TFR, patients are not exposed to unknown long-term adverse effects of TKIs and common adverse effects that may affect quality of life. Several factors need to b...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - October 8, 2020 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Time for More Inclusive Cancer Trials.
Authors: Dirix P, Wyld L, Paluch-Shimon S, Poortmans P PMID: 33022651 [PubMed - in process] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - October 8, 2020 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Telemedicine in Oncology and Reimbursement Policy During COVID-19 and Beyond.
Authors: Kircher SM, Mulcahy M, Kalyan A, Weldon CB, Trosman JR, Benson AB Abstract The first confirmed case of coronavirus disease 2019 (COVID-19) in the United States was reported on January 20, 2020. As of September 17, 2020, there were more than 6.6 million confirmed cases and 196,277 deaths. Limited data are available on outcomes of immunocompromised patients, but early published reports from China indicate that those with cancer have a 3.5 times higher risk of ICU admission, mechanical ventilation, or death than those without cancer. Because of the uncertain behavior of COVID-19, it has become imperative for ...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - October 2, 2020 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Elderly Black Non-Hispanic Patients With Head and Neck Squamous Cell Cancer Have the Worst Survival Outcomes.
CONCLUSIONS: Black non-Hispanic patients have a worse HNC prognosis than patients in all other racial/ethnic groups, including Hispanic patients. Modifiable risk factors include access to nonemergent care and prevention measures, such as tobacco cessation; presence of social support; communication barriers; and access to tertiary centers for appropriate treatment of their cancers. PMID: 32987364 [PubMed - as supplied by publisher] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - September 29, 2020 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Adjuvant Treatment of Early Ovarian Clear Cell Carcinoma: A Population-Based Study of Whole Abdominal Versus Pelvic Nodal Radiotherapy.
CONCLUSIONS: Adjuvant chemoRT was associated with a lower risk of failure compared with chemotherapy alone. However, there was no difference in OS between the adjuvant chemotherapy and chemoRT regimens. Additionally, no significant difference in terms of FFS or OS was found between the chemo-WART and chemo-PRT groups. PMID: 32971514 [PubMed - as supplied by publisher] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - September 26, 2020 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

NCCN Guidelines Insights: Kidney Cancer, Version 1.2021.
Authors: Motzer RJ, Jonasch E, Boyle S, Carlo MI, Manley B, Agarwal N, Alva A, Beckermann K, Choueiri TK, Costello BA, Derweesh IH, Desai A, George S, Gore JL, Haas N, Hancock SL, Kyriakopoulos C, Lam ET, Lau C, Lewis B, Madoff DC, McCreery B, Michaelson MD, Mortazavi A, Nandagopal L, Pierorazio PM, Plimack ER, Ponsky L, Ramalingam S, Shuch B, Smith ZL, Somer B, Sosman J, Dwyer MA, Motter AD Abstract The NCCN Guidelines for Kidney Cancer provide multidisciplinary recommendations for diagnostic workup, staging, and treatment of patients with renal cell carcinoma (RCC). These NCCN Guidelines Insights focus on recent ...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - September 6, 2020 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

A Practical Guide for Using Myelofibrosis Prognostic Models in the Clinic.
This article reviews the most widely adopted prognostic models used for PMF, including the International Prognostic Scoring System (IPSS), dynamic IPSS (DIPSS)/DIPSS+, mutation-enhanced IPSS for transplant-age patients (MIPSS70)/MIPSS70+/MIPSS70+ version 2.0, genetically inspired prognostic scoring system, and Myelofibrosis Secondary to PV and ET-Prognostic Model in patients with post-ET/PV myelofibrosis. We also discuss newly emerging prognostic models and provide a practical approach to risk stratification in patients with PMF and post-ET/PV myelofibrosis. PMID: 32886896 [PubMed - as supplied by publisher] (Source: J...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - September 6, 2020 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Clinical Utility of 18F-FDG PET/CT in Staging Localized Breast Cancer Before Initiating Preoperative Systemic Therapy.
CONCLUSIONS: Approximately 37% of patients with clinical stage IIA-IIIC breast cancer who underwent PET/CT before PST showed more extensive disease, including 23% with more extensive nodal metastasis and 14% with distant metastasis. Given its high detection rate, comparable cost, lower radiation dose, and greater convenience, PET/CT should be considered as an alternative to CTBS rather than "optional" after CTBS, especially in patients who require an efficient and expeditious workup before initiating PST. PMID: 32886897 [PubMed - as supplied by publisher] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - September 6, 2020 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Factors Associated With Detection and Survival of T1 Hepatocellular Carcinoma in the United States: National Cancer Database Analysis.
Authors: Yang JD, Luu M, Singal AG, Noureddin M, Kuo A, Ayoub WS, Sundaram V, Kotler H, Kim IK, Todo T, Voidonikolas G, Brennan TV, Kosari K, Klein AS, Hendifar A, Lu SC, Nissen NN, Gong J Abstract BACKGROUND: It remains unknown to what extent hepatocellular carcinomas (HCCs) are detected very early (T1 stage; ie, unifocal
Source: Journal of the National Comprehensive Cancer Network : JNCCN - September 6, 2020 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Multiorgan Immune-Related Adverse Events During Treatment With Atezolizumab.
Authors: Kichenadasse G, Miners JO, Mangoni AA, Rowland A, Hopkins AM, Sorich MJ Abstract BACKGROUND: Immune-related adverse events (irAEs) are known to occur in patients with cancer who are treated with immune checkpoint inhibitors. However, limited literature exists on the incidence, time of onset, and risk factors for irAEs, particularly those affecting multiple organs, associated with anti-PD-L1 inhibitors. METHODS: A post hoc pooled analysis was conducted using individual patient data from atezolizumab monotherapy arms of 4 non-small cell lung cancer clinical trials. Incidence, clinical patterns, outcomes,...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - September 6, 2020 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Conditional Survival and Cure of Patients With Colon or Rectal Cancer: A Population-Based Study.
CONCLUSIONS: The number of patients with CRC reaching cure has increased substantially over the years. This study's results provide valuable insights into trends of CRC patient survival and are important for patients, clinicians, and policymakers. PMID: 32886900 [PubMed - as supplied by publisher] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - September 6, 2020 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Cost-Effectiveness of Initial Versus Delayed Lanreotide for Treatment of Metastatic Enteropancreatic Neuroendocrine Tumors.
CONCLUSIONS: At its current price, lanreotide is not cost-effective as initial therapy for patients with metastatic enteropancreatic NETs and should be reserved for postprogression treatment. To be cost-effective as initial therapy, the price of lanreotide would need to be lowered by 48% to 95% or 27% to 86% to reach ICERs of $100,000/QALY or $150,00/QALY, respectively. PMID: 32886901 [PubMed - as supplied by publisher] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - September 6, 2020 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Myeloid/Lymphoid Neoplasms with Eosinophilia and TK Fusion Genes, Version 3.2021, NCCN Clinical Practice Guidelines in Oncology.
Authors: Gerds AT, Gotlib J, Bose P, Deininger MW, Dunbar A, Elshoury A, George TI, Gojo I, Gundabolu K, Hexner E, Hobbs G, Jain T, Jamieson C, Kuykendall AT, McMahon B, Mohan SR, Oehler V, Oh S, Pardanani A, Podoltsev N, Ranheim E, Rein L, Salit R, Snyder DS, Stein BL, Talpaz M, Thota S, Vachhani P, Wadleigh M, Walsh K, Ward DC, Bergman MA, Sundar H Abstract Eosinophilic disorders and related syndromes represent a heterogeneous group of neoplastic and nonneoplastic conditions, characterized by more eosinophils in the peripheral blood, and may involve eosinophil-induced organ damage. In the WHO classification of my...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - September 6, 2020 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Complexities of Next-Generation Sequencing in Solid Tumors: Case Studies.
This report presents 5 case studies illustrating challenges and opportunities in clinical next-generation sequencing interpretation and clinical application in solid tumor oncologic care. First is a case that dissects the origin of an ATM mutation as originating from a hematopoietic clone rather than the tumor. Second is a case illustrating the potential for tumor sequencing to suggest germline variants associated with a hereditary cancer syndrome. Third are 2 cases showing the potential for variant reclassification of a germline variant of uncertain significance when considered alongside family history and tumor sequencin...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - September 6, 2020 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

COVID-19 and Cancer: Unintended Consequences.
Authors: Tempero M PMID: 32886904 [PubMed - as supplied by publisher] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - September 6, 2020 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

What's in a Number? Examining the Prognostic and Predictive Importance of Platelet Count in Patients With Essential Thrombocythemia.
This article reviews the data that shed light on the importance of platelet count in patients with ET. PMID: 32886905 [PubMed - as supplied by publisher] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - September 6, 2020 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Immune-Related Adverse Events (irAEs): Implications for Immune Checkpoint Inhibitor Therapy.
Authors: Zhou N, Velez MA, Owen D, Lisberg AE PMID: 32886906 [PubMed - as supplied by publisher] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - September 6, 2020 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Depressive Symptoms in Danish Patients With Glioma and a Cancer-Free Comparison Group.
In this study, 363 of 554 patients with glioma and 481 of 1,304 cancer-free persons participated. Mean age of all patients was 55 years and 60% of the population was male. Mean scores for depressive symptoms were statistically significantly higher among patients with glioma, with a mean CES-D score of 10.9 (95% CI, 10.1-11.8) compared with 5.3 (95% CI, 4.7-5.8) among cancer-free persons (P
Source: Journal of the National Comprehensive Cancer Network : JNCCN - September 6, 2020 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

NCCN Patient Advocacy Summit: Delivering Value for Patients Across the Oncology Ecosystem.
This article encapsulates and expounds upon the discussions and presentations from the summit. PMID: 32886908 [PubMed - as supplied by publisher] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - September 6, 2020 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research