Journal Current Genomics: News and Editorial Prospects.
Authors: PMID: 32655284 [PubMed] (Source: Current Genomics)
Source: Current Genomics - July 14, 2020 Category: Genetics & Stem Cells Tags: Curr Genomics Source Type: research

Systems Genomics in the Age of Next Generation Sequencing (Part I).
Authors: Suravajhala P PMID: 32655285 [PubMed] (Source: Current Genomics)
Source: Current Genomics - July 14, 2020 Category: Genetics & Stem Cells Tags: Curr Genomics Source Type: research

Identification of Differentially Expressed Hematopoiesis-associated Genes in Term Low Birth Weight Newborns by Systems Genomics Approach.
Authors: Singh S, Singh VK, Rai G Abstract Background: Low Birth Weight (LBW) (birth weight
Source: Current Genomics - July 14, 2020 Category: Genetics & Stem Cells Tags: Curr Genomics Source Type: research

Understanding the Mechanism of Cell Death in Gemcitabine Resistant Pancreatic Ductal Adenocarcinoma: A Systems Biology Approach.
Conclusion: It was observed that EGF/VEGF signalling pathway played a major role in inducing drug resistance through cell growth, proliferation, and avoiding cell death. Targeting the major upstream components of this pathway could potentially lead to successful treatment. PMID: 32655287 [PubMed] (Source: Current Genomics)
Source: Current Genomics - July 14, 2020 Category: Genetics & Stem Cells Tags: Curr Genomics Source Type: research

Molecular and Genomic Characterization of PFAB2: A Non-virulent Bacillus anthracis Strain Isolated from an Indian Hot Spring.
Conclusion: The high replication rate in a wide range of temperatures and culture media, the non-pathogenicity, the good spore forming capability and its genomic similarity to the Ames strain together make PFAB2 an interesting model strain for the study of the pathogenic evolution of B. anthracis. PMID: 32655288 [PubMed] (Source: Current Genomics)
Source: Current Genomics - July 14, 2020 Category: Genetics & Stem Cells Tags: Curr Genomics Source Type: research

Computational Identification of piRNAs Using Features Based on RNA Sequence, Structure, Thermodynamic and Physicochemical Properties.
Conclusion: We obtained the highest performance in accurately predicting piRNAs as compared to the current state-of-the-art piRNA predictors. In conclusion, piRNAPred would be helpful to expand the piRNA repertoire, and provide new insights on piRNA functions. PMID: 32655289 [PubMed] (Source: Current Genomics)
Source: Current Genomics - July 14, 2020 Category: Genetics & Stem Cells Tags: Curr Genomics Source Type: research

Repurposing Pathogenic Variants of DMD Gene and its Isoforms for DMD Exon Skipping Intervention.
Conclusion: A major proportion of DMD subjects (80%) could be diagnosed by the MLPA technique. The data generated from our study may be beneficial for strengthening of mutation database in the North Indian population. PMID: 32655290 [PubMed] (Source: Current Genomics)
Source: Current Genomics - July 14, 2020 Category: Genetics & Stem Cells Tags: Curr Genomics Source Type: research

Identification of Two Novel Mutations in the ATM Gene from Patients with Ataxia-Telangiectasia by Whole Exome Sequencing.
Conclusion: Next-generation sequencing successfully identified the causative mutation in families with ataxia-telangiectasia. These novel mutations in the ATM gene reported in the present study could assist genetic counseling, Preimplantation Genetic Diagnosis (PGD) and prenatal diagnosis (PND) of AT. PMID: 32655291 [PubMed] (Source: Current Genomics)
Source: Current Genomics - July 14, 2020 Category: Genetics & Stem Cells Tags: Curr Genomics Source Type: research

Computational RNA Epigenetics.
Authors: Chen W PMID: 32655292 [PubMed] (Source: Current Genomics)
Source: Current Genomics - July 14, 2020 Category: Genetics & Stem Cells Tags: Curr Genomics Source Type: research

A Mini-review of the Computational Methods Used in Identifying RNA 5-Methylcytosine Sites.
Authors: Li J, Huang Y, Zhou Y Abstract RNA 5-methylcytosine (m5C) is one of the pillars of post-transcriptional modification (PTCM). A growing body of evidence suggests that m5C plays a vital role in RNA metabolism. Accurate localization of RNA m5C sites in tissue cells is the premise and basis for the in-depth understanding of the functions of m5C. However, the main experimental methods of detecting m5C sites are limited to varying degrees. Establishing a computational model to predict modification sites is an excellent complement to wet experiments for identifying m5C sites. In this review, we summarized some av...
Source: Current Genomics - July 14, 2020 Category: Genetics & Stem Cells Tags: Curr Genomics Source Type: research

A Brief Survey for MicroRNA Precursor Identification Using Machine Learning Methods.
Authors: Guan ZX, Li SH, Zhang ZM, Zhang D, Yang H, Ding H Abstract MicroRNAs, a group of short non-coding RNA molecules, could regulate gene expression. Many diseases are associated with abnormal expression of miRNAs. Therefore, accurate identification of miRNA precursors is necessary. In the past 10 years, experimental methods, comparative genomics methods, and artificial intelligence methods have been used to identify pre-miRNAs. However, experimental methods and comparative genomics methods have their disadvantages, such as time-consuming. In contrast, machine learning-based method is a better choice. Therefore...
Source: Current Genomics - July 14, 2020 Category: Genetics & Stem Cells Tags: Curr Genomics Source Type: research

Extremely-randomized-tree-based Prediction of N6-Methyladenosine Sites in Saccharomyces cerevisiae.
Conclusion: In summary, ERT-m6Apred predicts Saccharomyces cerevisiae m6A sites with higher accuracy, thus facilitating biological hypothesis generation and experimental validations. PMID: 32655295 [PubMed] (Source: Current Genomics)
Source: Current Genomics - July 14, 2020 Category: Genetics & Stem Cells Tags: Curr Genomics Source Type: research

DNA Methylation and Bladder Cancer: Where Genotype does not Predict Phenotype.
Authors: Sharma A, Reutter H, Ellinger J Abstract Nearly three decades ago, the association between Bladder cancer (BC) and DNA methylation has initially been reported. Indeed, in the recent years, the mechanism connecting these two has gained deeper insights. Still, the mediocre performance of DNA methylation markers in the clinics raises the major concern. Strikingly, whether it is the inter-individual methylation variations or the paucity of knowledge about methylation fingerprints lying within histologically distinct subtypes of BC requires critical discussion. In the future, besides identifying the initial cau...
Source: Current Genomics - July 14, 2020 Category: Genetics & Stem Cells Tags: Curr Genomics Source Type: research

Novel Approaches to Profile Functional Long Noncoding RNAs Associated with Stem Cell Pluripotency.
Authors: Zhu Y, Yan Z, Tang Z, Li W Abstract The pluripotent state of stem cells depends on the complicated network orchestrated by thousands of factors and genes. Long noncoding RNAs (lncRNAs) are a class of RNA longer than 200 nt without a protein-coding function. Single-cell sequencing studies have identified hundreds of lncRNAs with dynamic changes in somatic cell reprogramming. Accumulating evidence suggests that they participate in the initiation of reprogramming, maintenance of pluripotency, and developmental processes by cis and/or trans mechanisms. In particular, they may interact with proteins, RNAs, and ...
Source: Current Genomics - July 14, 2020 Category: Genetics & Stem Cells Tags: Curr Genomics Source Type: research

Exosomal miR-1298 and lncRNA-RP11-583F2.2 Expression in Hepato-cellular Carcinoma.
Conclusion: The exosomal hsa-miRNA-1298, lncRNA-RP11-583F2.2 can be potential biomarkers for HCC diagnosis. PMID: 32655298 [PubMed] (Source: Current Genomics)
Source: Current Genomics - July 14, 2020 Category: Genetics & Stem Cells Tags: Curr Genomics Source Type: research

The Experimentally Obtained Functional Impact Assessments of 5' Splice Site GT'GC Variants Differ Markedly from Those Predicted.
Conclusion: Our findings highlight the challenges that we still face in attempting to accurately identify splice-altering variants. PMID: 32655299 [PubMed] (Source: Current Genomics)
Source: Current Genomics - July 14, 2020 Category: Genetics & Stem Cells Tags: Curr Genomics Source Type: research

WITMSG: Large-scale Prediction of Human Intronic m6A RNA Methylation Sites from Sequence and Genomic Features.
Conclusion: It has been observed that WITMSG outperformed competing approaches (trained with all the m6A sites or intronic m6A sites only) in 10-fold cross-validation (AUC: 0.940) and when tested on independent datasets (AUC: 0.946). WITMSG was also applied intronome-wide in humans to predict all possible intronic m6A sites, and the prediction results are freely accessible at http://rnamd.com/intron/. PMID: 32655300 [PubMed] (Source: Current Genomics)
Source: Current Genomics - July 14, 2020 Category: Genetics & Stem Cells Tags: Curr Genomics Source Type: research

Meet Our Executive Guest Editor.
Authors: Yang C PMID: 32655301 [PubMed] (Source: Current Genomics)
Source: Current Genomics - July 14, 2020 Category: Genetics & Stem Cells Tags: Curr Genomics Source Type: research

Genomics of Extremophiles for Sustainable Agriculture and Biotechnological Applications (Part I).
Authors: Vaishnav A, Sahu J, Singh HB PMID: 32655302 [PubMed] (Source: Current Genomics)
Source: Current Genomics - July 14, 2020 Category: Genetics & Stem Cells Tags: Curr Genomics Source Type: research

Engineered Microbes for Pigment Production Using Waste Biomass.
Authors: Usmani Z, Sharma M, Sudheer S, Gupta VK, Bhat R Abstract Agri-food waste biomass is the most abundant organic waste and has high valorisation potential for sustainable bioproducts development. These wastes are not only recyclable in nature but are also rich sources of bioactive carbohydrates, peptides, pigments, polyphenols, vitamins, natural antioxidants, etc. Bioconversion of agri-food waste to value-added products is very important towards zero waste and circular economy concepts. To reduce the environmental burden, food researchers are seeking strategies to utilize this waste for microbial pigments pro...
Source: Current Genomics - July 14, 2020 Category: Genetics & Stem Cells Tags: Curr Genomics Source Type: research

Extremophile - An Adaptive Strategy for Extreme Conditions and Applications.
Authors: Kohli I, Joshi NC, Mohapatra S, Varma A Abstract The concurrence of microorganisms in niches that are hostile like extremes of temperature, pH, salt concentration and high pressure depends upon novel molecular mechanisms to enhance the stability of their proteins, nucleic acids, lipids and cell membranes. The structural, physiological and genomic features of extremophiles that make them capable of withstanding extremely selective environmental conditions are particularly fascinating. Highly stable enzymes exhibiting several industrial and biotechnological properties are being isolated and purified from the...
Source: Current Genomics - July 14, 2020 Category: Genetics & Stem Cells Tags: Curr Genomics Source Type: research

Quantification of Naphthalene Dioxygenase (NahAC) and Catechol Dioxygenase (C23O) Catabolic Genes Produced by Phenanthrene-Degrading Pseudomonas fluorescens AH-40.
Conclusion: nahAc and C23O genes are the main marker genes for phenanthrene degradation by strain AH-40. P. fluorescence AH-40 could be recommended for bioremediation of phenanthrene contaminated site. PMID: 32655305 [PubMed] (Source: Current Genomics)
Source: Current Genomics - July 14, 2020 Category: Genetics & Stem Cells Tags: Curr Genomics Source Type: research

In Silico Transcriptomic Analysis of the Chloride Intracellular Channels (CLIC) Interactome Identifies a Molecular Panel of Seven Prognostic Markers in Patients with Pancreatic Ductal Adenocarcinoma.
Conclusion: These outcomes demonstrate a seven-gene molecular panel that predicts the patients' prospective survival following pancreatic resection for PDAC. PMID: 32655306 [PubMed] (Source: Current Genomics)
Source: Current Genomics - July 14, 2020 Category: Genetics & Stem Cells Tags: Curr Genomics Source Type: research

Genome Sequence of a Highly Virulent pvl-positive Vancomycin-intermediate-resistant Staphylococcus aureus Sequence Type 30.
Conclusion: We described for the first time the genome sequence of a VISA isolate harboring two pvl-associated genes and other virulence factors that may improve the USA1100/ST30 lineage fitness and impact its pathogenicity and spreading at Brazilian hospitals. PMID: 32655307 [PubMed] (Source: Current Genomics)
Source: Current Genomics - July 14, 2020 Category: Genetics & Stem Cells Tags: Curr Genomics Source Type: research

Phylogenomic Analysis of R2R3 MYB Transcription Factors in Sorghum and their Role in Conditioning Biofuel Syndrome.
Conclusion: The results presented here are pivotal to prioritize MYB genes for functional validation and optimize agronomic traits in sorghum. PMID: 32655308 [PubMed] (Source: Current Genomics)
Source: Current Genomics - July 14, 2020 Category: Genetics & Stem Cells Tags: Curr Genomics Source Type: research

Systems Genomics in the Age of Next Generation Sequencing (Part II).
Authors: Suravajhala P PMID: 32581641 [PubMed] (Source: Current Genomics)
Source: Current Genomics - June 27, 2020 Category: Genetics & Stem Cells Tags: Curr Genomics Source Type: research

Applications of Machine Learning in miRNA Discovery and Target Prediction.
Authors: Parveen A, Mustafa SH, Yadav P, Kumar A Abstract MicroRNA (miRNA) is a small non-coding molecule that is involved in gene regulation and RNA silencing by complementary on their targets. Experimental methods for target prediction can be time-consuming and expensive. Thus, the application of the computational approach is implicated to enlighten these complications with experimental studies. However, there is still a need for an optimized approach in miRNA biology. Therefore, machine learning (ML) would initiate a new era of research in miRNA biology towards potential diseases biomarker. In this article, we d...
Source: Current Genomics - June 27, 2020 Category: Genetics & Stem Cells Tags: Curr Genomics Source Type: research

Deciphering the Novel Target Genes Involved in the Epigenetics of Hepatocellular Carcinoma Using Graph Theory Approach.
Conclusion: The top ten novel epigenetic target genes involved in HCC reported in this study are cdk6, cdk4, cdkn2a, smad7, smad3, ccnd1, e2f1, sf3b1, ctnnb1, and tgfb1. PMID: 32581643 [PubMed] (Source: Current Genomics)
Source: Current Genomics - June 27, 2020 Category: Genetics & Stem Cells Tags: Curr Genomics Source Type: research

Helicobacter pylori Reactivates Human Immunodeficiency Virus-1 in Latently Infected Monocytes with Increased Expression of IL-1 β and CXCL8.
Helicobacter pylori Reactivates Human Immunodeficiency Virus-1 in Latently Infected Monocytes with Increased Expression of IL-1β and CXCL8. Curr Genomics. 2019 Dec;20(8):556-568 Authors: Natarajan V, Moar P, Kaur US, Venkatesh V, Kumar A, Chaturvedi R, Himanshu D, Tandon R Abstract Background: Helicobacter pylori are gram-negative bacteria, which colonize the human stomach. More than 50% of the world's population is infected by H. pylori. Based on the high prevalence of H. pylori, it is very likely that HIV and H. pylori infection may coexist. However, the molecular events that occur during HIV-H....
Source: Current Genomics - June 27, 2020 Category: Genetics & Stem Cells Tags: Curr Genomics Source Type: research

Cell-free microRNAs as Non-invasive Diagnostic and Prognostic Bio- markers in Pancreatic Cancer.
Authors: Gablo NA, Prochazka V, Kala Z, Slaby O, Kiss I Abstract Pancreatic cancer (PaC) is one of the most lethal cancers, with an increasing global incidence rate. Unfavorable prognosis largely results from associated difficulties in early diagnosis and the absence of prognostic and predictive biomarkers that would enable an individualized therapeutic approach. In fact, PaC prognosis has not improved for years, even though much efforts and resources have been devoted to PaC research, and the multimodal management of PaC patients has been used in clinical practice. It is thus imperative to develop optimal biomarke...
Source: Current Genomics - June 27, 2020 Category: Genetics & Stem Cells Tags: Curr Genomics Source Type: research

IMPMD: An Integrated Method for Predicting Potential Associations Between miRNAs and Diseases.
Conclusion: We built a software named IMPMD which can be freely downloaded from https://github.com/Sunmile/IMPMD. PMID: 32581646 [PubMed] (Source: Current Genomics)
Source: Current Genomics - June 27, 2020 Category: Genetics & Stem Cells Tags: Curr Genomics Source Type: research

Identify Lysine Neddylation Sites Using Bi-profile Bayes Feature Extraction via the Chou's 5-steps Rule and General Pseudo Components.
Conclusion: Therefore, NeddPred can be a complement to the existing tools for the prediction of neddylation sites. A user-friendly webserver for NeddPred is accessible at 123.206.31.171/NeddPred/. PMID: 32581647 [PubMed] (Source: Current Genomics)
Source: Current Genomics - June 27, 2020 Category: Genetics & Stem Cells Tags: Curr Genomics Source Type: research

Meet Our Section Editor.
Authors: Stella F PMID: 32476987 [PubMed] (Source: Current Genomics)
Source: Current Genomics - June 3, 2020 Category: Genetics & Stem Cells Tags: Curr Genomics Source Type: research

Understanding Non-Mendelian Genetic Risk.
Authors: Coetzee GA Abstract This opinion paper highlights strategies for a better understanding of non-Mendelian genetic risk that was revealed by genome-wide association studies (GWAS) of complex diseases. The genetic risk resides predominantly in non-coding regulatory DNA, such as in enhancers. The identification of mechanisms, the causal variants (mainly SNPs), and their target genes are, however, not always apparent but are likely involved in a network of risk determinants; the identification presents a bottle-neck in the full understanding of the genetics of complex phenotypes. Here, we propose strategies to ...
Source: Current Genomics - June 3, 2020 Category: Genetics & Stem Cells Tags: Curr Genomics Source Type: research

Available Software for Meta-analyses of Genome-wide Expression Studies.
Authors: Forero DA Abstract Advances in transcriptomic methods have led to a large number of published Genome-Wide Expression Studies (GWES), in humans and model organisms. For several years, GWES involved the use of microarray platforms to compare genome-expression data for two or more groups of samples of interest. Meta-analysis of GWES is a powerful approach for the identification of differentially expressed genes in biological topics or diseases of interest, combining information from multiple primary studies. In this article, the main features of available software for carrying out meta-analysis of GWES have b...
Source: Current Genomics - June 3, 2020 Category: Genetics & Stem Cells Tags: Curr Genomics Source Type: research

Post-translational Modifications are Required for Circadian Clock Regulation in Vertebrates.
Authors: Okamoto-Uchida Y, Izawa J, Nishimura A, Hattori A, Suzuki N, Hirayama J Abstract Circadian clocks are intrinsic, time-tracking systems that bestow upon organisms a survival advantage. Under natural conditions, organisms are trained to follow a 24-h cycle under environmental time cues such as light to maximize their physiological efficiency. The exact timing of this rhythm is established via cell-autonomous oscillators called cellular clocks, which are controlled by transcription/translation-based negative feedback loops. Studies using cell-based systems and genetic techniques have identified the molecular ...
Source: Current Genomics - June 3, 2020 Category: Genetics & Stem Cells Tags: Curr Genomics Source Type: research

Identification of Novel Molecular Network Expression in Acute Myocardial Infarction.
Conclusion: Of note, the investigated serum RNAs decrease the false discovery rate of AMI to 3.2%. PMID: 32476991 [PubMed] (Source: Current Genomics)
Source: Current Genomics - June 3, 2020 Category: Genetics & Stem Cells Tags: Curr Genomics Source Type: research

Bioinformatics Analysis based on Multiple Databases Identifies Hub Genes Associated with Hepatocellular Carcinoma.
Conclusion: TOP2A, NDC80, CDK1, CCNB1, KIF11, BUB1, CCNB2, CCNA2 and TTK were hub genes in HCC, which may be potential biomarkers of HCC and targets of HCC therapy. PMID: 32476992 [PubMed] (Source: Current Genomics)
Source: Current Genomics - June 3, 2020 Category: Genetics & Stem Cells Tags: Curr Genomics Source Type: research

LipoSVM: Prediction of Lysine Lipoylation in Proteins based on the Support Vector Machine.
Conclusion: A good predictor for lysine lipoylation is built based on position-specific scoring matrix and support vector machine. Meanwhile, an online webserver LipoSVM can be freely downloaded from https://github.com/stars20180811/LipoSVM. PMID: 32476993 [PubMed] (Source: Current Genomics)
Source: Current Genomics - June 3, 2020 Category: Genetics & Stem Cells Tags: Curr Genomics Source Type: research

The TIFY Gene Family in Wheat and its Progenitors: Genome-wide Identification, Evolution and Expression Analysis.
Conclusion: This study systematically reported the characteristics of the wheat TIFY family, which ultimately provided important targets for further functional analysis and also facilitated the elucidation of the evolution mechanism of TIFY genes in wheat and more. PMID: 32476994 [PubMed] (Source: Current Genomics)
Source: Current Genomics - June 3, 2020 Category: Genetics & Stem Cells Tags: Curr Genomics Source Type: research

Computational Prediction of Ubiquitination Proteins Using Evolutionary Profiles and Functional Domain Annotation.
Conclusion: Our study may guide experimental design and provide useful insights for studying the mechanisms and modulation of ubiquitination pathways. The code is available at: https://github.com/Chunhuixu/UBIPredic_QWRCHX. PMID: 32476995 [PubMed] (Source: Current Genomics)
Source: Current Genomics - June 3, 2020 Category: Genetics & Stem Cells Tags: Curr Genomics Source Type: research

The Critical Role of Epigenetic Regulation in Developmental Programming of Higher Organisms.
Authors: Vaschetto LM, Editor G PMID: 32476996 [PubMed] (Source: Current Genomics)
Source: Current Genomics - June 3, 2020 Category: Genetics & Stem Cells Tags: Curr Genomics Source Type: research

The Role of Sequence Duplication in Transcriptional Regulation and Genome Evolution.
Authors: Vaschetto LM, Ortiz N Abstract Sequence duplication is nowadays recognized as an important mechanism that underlies the evolution of eukaryote genomes, being indeed one of the most powerful strategies for the generation of adaptive diversity by modulating transcriptional activity. The evolutionary novelties simultaneously associated with sequence duplication and differential gene expression can be collectively referred to as duplication-mediated transcriptional regulation. In the last years, evidence has emerged supporting the idea that sequence duplication and functionalization represent important evoluti...
Source: Current Genomics - June 3, 2020 Category: Genetics & Stem Cells Tags: Curr Genomics Source Type: research

Hormonal Imprinting: The First Cellular-level Evidence of Epigenetic Inheritance and its Present State.
Authors: Csaba G Abstract Hormonal imprinting takes place perinatally at the first encounter between the developing hormone receptor and its target hormone. This process is needed for the normal function of the receptor-hormone pair and its effect is life-long. However, in this critical period, when the developmental window is open, related molecules (members of the same hormone family, synthetic hormones and hormone-like molecules, endocrine disruptors) also can be bound by the receptor, causing life-long faulty imprinting. In this case, the receptors' binding capacity changes and alterations are caused at adult a...
Source: Current Genomics - June 3, 2020 Category: Genetics & Stem Cells Tags: Curr Genomics Source Type: research

Maternal Obesity, Maternal Overnutrition and Fetal Programming: Effects of Epigenetic Mechanisms on the Development of Metabolic Disorders.
Conclusion: Weight management before and during pregnancy, together with healthy nutritional intakes may improve the maternal metabolic environment, which can reduce the risks of fetal programming of metabolic diseases. Further evidence from long-term follow-up studies are needed in order to determine the role of maternal obesity on epigenetic mechanisms. PMID: 32476999 [PubMed] (Source: Current Genomics)
Source: Current Genomics - June 3, 2020 Category: Genetics & Stem Cells Tags: Curr Genomics Source Type: research

Epigenetic Programming of Adipose Tissue in the Progeny of Obese Dams.
Authors: Lecoutre S, Kwok KHM, Petrus P, Lambert M, Breton C Abstract According to the Developmental Origin of Health and Disease (DOHaD) concept, maternal obesity and the resulting accelerated growth in neonates predispose offspring to obesity and associated metabolic diseases that may persist across generations. In this context, the adipose tissue has emerged as an important player due to its involvement in metabolic health, and its high potential for plasticity and adaptation to environmental cues. Recent years have seen a growing interest in how maternal obesity induces long-lasting adipose tissue remodeling in...
Source: Current Genomics - June 3, 2020 Category: Genetics & Stem Cells Tags: Curr Genomics Source Type: research

Early-life Programming of Type 2 Diabetes Mellitus: Understanding the Association between Epigenetics/Genetics and Environmental Factors.
Authors: Kadayifci FZ, Haggard S, Jeon S, Ranard K, Tao D, Pan YX Abstract Type 2 Diabetes Mellitus is an increasing public health problem that poses a severe social and economic burden affecting both developed and developing countries. Defects in insulin signaling itself are among the earliest indications that an individual is predisposed to the development of insulin resistance and subsequently Type 2 Diabetes Mellitus. To date, however, the underlying molecular mechanisms which result in resistance to the actions of insulin are poorly understood. Furthermore, it has been shown that maternal obesity is associated...
Source: Current Genomics - June 3, 2020 Category: Genetics & Stem Cells Tags: Curr Genomics Source Type: research

Hematopoietic Differentiation of Human Pluripotent Stem Cells: HOX and GATA Transcription Factors as Master Regulators.
Authors: Alsayegh K, Cortés-Medina LV, Ramos-Mandujano G, Badraiq H, Li M Abstract Numerous human disorders of the blood system would directly or indirectly benefit from therapeutic approaches that reconstitute the hematopoietic system. Hematopoietic stem cells (HSCs), either from matched donors or ex vivo manipulated autologous tissues, are the most used cellular source of cell therapy for a wide range of disorders. Due to the scarcity of matched donors and the difficulty of ex vivo expansion of HSCs, there is a growing interest in harnessing the potential of pluripotent stem cells (PSCs) as a de novo sourc...
Source: Current Genomics - March 22, 2020 Category: Genetics & Stem Cells Tags: Curr Genomics Source Type: research

Comprehensive Analysis of the mRNA-lncRNA Co-expression Profile and ceRNA Networks Patterns in Chronic Hepatitis B.
Conclusion: Our study provides insights into the roles of mRNA and lncRNA networks in CHB, high-lighting potential applications of lncRNA-T039096 and mRNA-ZFP57 for diagnosis and treatment. PMID: 32030083 [PubMed] (Source: Current Genomics)
Source: Current Genomics - February 8, 2020 Category: Genetics & Stem Cells Tags: Curr Genomics Source Type: research

A Genetic Predictive Model Estimating the Risk of Developing Adolescent Idiopathic Scoliosis.
Authors: Xu L, Wu Z, Xia C, Tang N, Cheng JCY, Qiu Y, Zhu Z Abstract Background: Previous GWASs have revealed several susceptible variants associated with adolescent idiopathic scoliosis (AIS). Risk prediction based on these variants can potentially improve disease prognosis. We aimed to evaluate the combined effects of genetic factors on the development of AIS and to further develop a genetic predictive model. Methods: A total of 914 AIS patients and 1441 normal controls were included in the discovery stage, which was followed by the replication stage composed of 871 patients and 1239 controls. Genotyping assa...
Source: Current Genomics - February 8, 2020 Category: Genetics & Stem Cells Tags: Curr Genomics Source Type: research