Antibacterial activities and antiproliferative assays over a tumor cells panel of a silver complex with 4-aminobenzoic acid: Studies in vitro of sustained release using bacterial cellulose membranes as support.
Lustri WR Abstract The aims of this work were to evaluate the antibacterial and antiproliferative potential in vitro of the metal complex with 4-aminobenzoic acid (Ag-pABA) and a drug delivery system based on bacterial cellulose (BC-Ag-pABA). The Ag-pABA complex was characterized by elemental analysis, high resolution mass spectrometry and single-crystal X-ray diffraction techniques, which indicated a 1:2 metal/pABA composition plus a nitrate ion coordinated to silver by the oxygen atom, with the coordination formula [Ag (C7H7NO2)2(NO3)]. The coordination of pABA to the silver ion occurred by the nitrogen atom. Th...
Source: Journal of Inorganic Biochemistry - September 6, 2020 Category: Biochemistry Authors: Aquaroni NAS, Nakahata DH, Lazarini SC, Resende FA, Cândido ALP, da Silva Barud H, Claro AM, de Carvalho JE, Ribeiro CM, Pavan FR, Lustri BC, Ribeiro TRM, Moreira CG, Cândido TZ, Lima CSP, Ruiz ALTG, Corbi PP, Lustri WR Tags: J Inorg Biochem Source Type: research

Cu(II) complexes with peptides from FomA protein containing -His-Xaa-Yaa-Zaa-His and -His-His-motifs. ROS generation and DNA degradation.
ska N Abstract Mono- and dinuclear Cu(II) complexes with Ac-PTVHNEYH-NH2 (L1) and Ac-NHHTLND-NH2 (L2) peptides from FomA protein of Fusobacterium nucleatum were studied by potentiometry, spectroscopic methods (UV-Vis, CD, EPR) and MS technique. The dominant mononuclear complexes for L1 ligand are: CuHL (pH range 5.0-6.0) with 2N {2Nim}, CuH-2L (pH range 8.0-8.5) and CuH-3L species (above pH 9.0) with 4N {Nim, 3N-} coordination modes. The complexes: CuH-1L with 3N {2Nim, N-}, CuH-2L with 3N {Nim, 2N-} and CuH-3L with 4N {Nim, 3N-} binding sites are proposed for the L2 ligand. Probably in the CuH-2L complex for Cu...
Source: Journal of Inorganic Biochemistry - September 6, 2020 Category: Biochemistry Authors: Lesiów MK, Bieńko A, Sobańska K, Kowalik-Jankowska T, Rolka K, Łęgowska A, Ptaszyńska N Tags: J Inorg Biochem Source Type: research

Harnessing Peptides against lead pollution and poisoning: Achievements and prospects.
Abstract Among the broad applicability of peptides in numerous aspects of life and technologies, their interactions with lead (Pb), one of the most harmful substances to the environment and health, are constantly explored. So far, peptides were developed for environmental remediation of Pb-contaminations by various strategies such as hydrogelation and surface display. They were also designed for Pb detection and sensing by electrochemical and fluorescent methods and for modeling natural proteins that involve in mechanisms by which Pb is toxic. This review aims at summarizing selected examples of these applications...
Source: Journal of Inorganic Biochemistry - September 4, 2020 Category: Biochemistry Authors: Sauser L, Shoshan MS Tags: J Inorg Biochem Source Type: research

Anti-diabetic and anti-parasitic properties of a family of luminescent zinc coordination compounds based on the 7-amino-5-methyl-1,2,4-triazolo[1,5-a]pyrimidine ligand.
We report on the formation of a triazolopyrimidine derivative ligand, 7-amino-5-methyl-1,2,4-triazolo[1,5-a]pyrimidine (7-amtp), and a new family of coordination compounds based on this ligand and zinc as metal ion, synthesized by conventional routes. These materials possess different mononuclear structures, namely [ZnCl2(7-amtp)2] (1), [Zn(7-amtp)2(H2O)4](NO3)2·2(7-amtp)·6H2O (2) and [Zn(7-amtp)2(H2O)4](SO4)·1.5H2O (3) derived from the use of different zinc (II) salts, in such a way that the counterions govern the crystallization to a large extent. These compounds present and show variable luminescent...
Source: Journal of Inorganic Biochemistry - August 23, 2020 Category: Biochemistry Authors: Esteban-Parra GM, Sebastián ES, Cepeda J, Sánchez-González C, Rivas-García L, Llopis J, Aranda P, Sánchez-Moreno M, Quirós M, Rodríguez-Diéguez A Tags: J Inorg Biochem Source Type: research

Structure and anticancer activity of Cu(II) complexes with (bromophenyl)thiourea moiety attached to the polycyclic imide.
Abstract A series of nine copper complexes were synthesized by reacting 1,3-disubstituted thioureas with copper(II) chloride. The new compounds were characterized by elemental analysis, infrared, ultraviolet-visible and X-ray absorption spectroscopies as well as molecular modelling. The molecular structure of complexes in the solid state consists of two thiourea ligands chelated to the Cu(II) ion through the S and deprotonated N atoms (CuN2S2). The coordination polyhedron of metal cation in powdered samples exhibits two different geometries. Pseudo-tetrahedral structure is observed for noncentrosymmetric complexes...
Source: Journal of Inorganic Biochemistry - August 21, 2020 Category: Biochemistry Authors: Drzewiecka-Antonik A, Rejmak P, Klepka M, Wolska A, Chrzanowska A, Struga M Tags: J Inorg Biochem Source Type: research

Application and prospect of antimonene: A new two-dimensional nanomaterial in cancer theranostics.
Abstract With the rise of two-dimensional nanomaterials in medicine, finding suitable materials has become our top priority. Since the first report of antimonene in 2015, due to its excellent physical and chemical properties, it has gradually attracted widespread attention, including its application prospects in cancer treatment. In this paper, the preparation, stability and infrared degradability of antimonene, as well as its experimental examples in tumor treatment in recent years are reviewed, the latest research results are listed and summarized, the advantages and existing problems are analyzed, and the futur...
Source: Journal of Inorganic Biochemistry - August 21, 2020 Category: Biochemistry Authors: Yang X, Wu R, Xu N, Li X, Dong N, Ling G, Liu Y, Zhang P Tags: J Inorg Biochem Source Type: research

Boosting type I process of Ru(II) compounds by changing tetrazole ligand for enhanced photodynamic therapy against lung cancer.
Abstract Boosting the photosensitization type I process will enhance the phototherapy efficacy because the superoxide radicals (O2-) generated during type I process are more toxic than the singlet oxygen (1O2) in type II process. Herein, [Ru(Hdtza)(phen)2][PF6] (1) and [Ru(pytz)(phen)2][PF6] (2) (phen = 1,10-phenanthroline) based on two nitrogen-rich tetrazole ligands, di(2H-tetrazol-5-yl) amine (H2dtza) and 5-(2-pyridyl)tetrazole (Hpytz) have been developed for photodynamic therapy (PDT) against lung cancer, respectively. Nanoprecipitation was used to prepare the nanoparticles (NPs) of both compounds. [...
Source: Journal of Inorganic Biochemistry - August 21, 2020 Category: Biochemistry Authors: Zhang X, Huang X, Xie A, Zhang X, Deng J, Zou D, Zou J Tags: J Inorg Biochem Source Type: research

mTORC1 activation contributes to autophagy inhibition via its recruitment to lysosomes and consequent lysosomal dysfunction in cadmium-exposed rat proximal tubular cells.
Abstract Autophagy dysregulation is implicated in cadmium (Cd)-induced nephrotoxicity. The mammalian target of rapamycin complex 1 (mTORC1) is a negative regulator of autophagy, but its role in Cd-induced autophagy inhibition and possible regulatory mechanisms remains poorly understood. In the present study, Cd exposure activated mTORC1 in primary rat proximal tubular (rPT) cells, and two mTORC1 inhibitors (rapamycin and torin 1) were separately utilized to inhibit Cd-induced mTORC1 activation. Data showed that Cd-inhibited autophagic flux was markedly restored by two mTORC1 inhibitors, respectively, as evidenced ...
Source: Journal of Inorganic Biochemistry - August 21, 2020 Category: Biochemistry Authors: Lian CY, Yang H, Zhai ZZ, Li ZF, Han DG, Wang L Tags: J Inorg Biochem Source Type: research

Fabrication of PNIPAM-chitosan/decatungstoeuropate/silica nanocomposite for thermo/pH dual-stimuli-responsive and luminescent drug delivery system.
Abstract A luminescent and dual-stimuli-responsive nanocomposite based on mesoporous silica, poly (N-isopropylacrylamide)-chitosan and decatungstoeuropate was prepared. To fabricate the nanocomposite, the mesoporous silica nanoparticles were coated with thermo/pH dual-responsive poly (N-isopropylacrylamide)-chitosan and the luminescent decatungstoeuropate particles were grafted onto copolymers. The designed nanocarrier could show exhibit good red luminescence as well as obvious thermo/pH stimuli-responsive properties, which could be employed as a drug storage reservoir for the loading and release of anticancer dru...
Source: Journal of Inorganic Biochemistry - August 10, 2020 Category: Biochemistry Authors: Huang N, Wang J, Cheng X, Xu Y, Li W Tags: J Inorg Biochem Source Type: research

Unfolding cytochromes c-b562 and Rd apo b562.
ez RA Abstract We have analyzed the early stages of unfolding of cytochromes c-b562 (PDB ID: 2BC5) and Rd apo b562 (PDB ID: 1YYJ). Our geometrical approach proceeds from an analysis of the crystal structure reported for each protein. We quantify, residue-by-residue and region-by-region, the spatial and angular changes in the structure as the protein denatures, and quantify differences that result from the seven residues that differ in the two proteins. Using two independent analyses, one based on spatial metrics and the second on angular metrics, we establish the order of unfolding of the five helices in cyt c-b56...
Source: Journal of Inorganic Biochemistry - August 10, 2020 Category: Biochemistry Authors: Kozak JJ, Gray HB, Garza-López RA Tags: J Inorg Biochem Source Type: research

Evaluation of cobalt(III) complexes as potential hypoxia-responsive carriers of esculetin.
Abstract Differentiation between hypoxic and normoxic tissues have been exploited for the development of selective chemotherapeutic agents. In this context, cobalt(III)-based coordination compounds have been designed and investigated as prospective hypoxia-responsive drug delivery systems. Three cobalt(III) complexes, namely [CoIII(esc)(py2en)]ClO4·(CH3OH)2 (1) [CoIII(esc)(TPA)]ClO4·3H2O (2) and [CoIII(bipy)2(esc)]ClO4·2.5H2O (3) (py2en = N,N'-bis(pyridin-2-ylmethyl)ethylenediamine, TPA = tris(2-pyridylmethyl)amine, bipy = 2,2'-bipyridine and esc = 6,7-d...
Source: Journal of Inorganic Biochemistry - August 8, 2020 Category: Biochemistry Authors: Palmeira-Mello MV, Caballero AB, Ribeiro JM, de Souza-Fagundes EM, Gamez P, Lanznaster M Tags: J Inorg Biochem Source Type: research

Synthesis of biocompatible silver nanoparticles by a modified polyol method for theranostic applications: Studies on red blood cells, internalization ability and antibacterial activity.
Abstract Recently, there has been ongoing research in the field of nanotechnology and nanomedicine aiming at developing multifunctional biomaterials using noble metals. The unique properties of silver (Ag) are known from ancient times and thus are being explored for their behavior on the nano scale. Silver shows high antimicrobial activity against different microorganisms, while modification of the surface of its nanostructures can be useful in active targeting regarding cancer treatment. During the synthetic procedure, in order to obtain a more uniform sample of silver nanoparticles (Ag NPs) with spherical morpho...
Source: Journal of Inorganic Biochemistry - August 1, 2020 Category: Biochemistry Authors: Sofia NG, Nikos B, Elias S, Eleni EK Tags: J Inorg Biochem Source Type: research

Arsenic (III) and/or copper (II) induces oxidative stress in chicken brain and subsequent effects on mitochondrial homeostasis and autophagy.
This study is designed to analyze the nervous system damage induced by As and/or Cu exposure from both structural and molecular levels. Under the As and/or Cu stress, local hemorrhage, inflammatory infiltration and mitochondrial damage were observed. Enzymes and non-enzyme antioxidants clearly show that the redox balance is deviated gradually. The results of real-time quantitative PCR and Western blotting revealed that there may be a cascading effect between oxidative stress and disruption of mitochondrial dynamics, the key protein of mitochondrial fusion has decreased and the fission protein has increased. The superpositi...
Source: Journal of Inorganic Biochemistry - August 1, 2020 Category: Biochemistry Authors: Liu Y, Zhao H, Wang Y, Guo M, Mu M, Xing M Tags: J Inorg Biochem Source Type: research

Synthesis, structure, and biological activity of bis(benzimidazole)amino thio- and selenoether nickel complexes.
Martínez-Otero D, Castillo I Abstract Four new nickel (II) complexes with bis(benzimidazole)thio- and selenoether-based ligands have been synthesized and characterized in the solid state by elemental analysis, IR, magnetic susceptibility and X-ray crystallography, and in solution by FAB+ mass spectrometry, UV-vis spectroscopy and cyclic voltammetry. Single-crystal X-ray diffraction analysis of the compounds revealed octahedral geometries for all nickel centers. Three of the four complexes are dimers with chloride bridges between the two Ni(II) ions. However, in solution all complexes have a monomeric formul...
Source: Journal of Inorganic Biochemistry - July 28, 2020 Category: Biochemistry Authors: Muñoz-Patiño N, Sánchez-Eguía BN, Araiza-Olivera D, Flores-Alamo M, Hernández-Ortega S, Martínez-Otero D, Castillo I Tags: J Inorg Biochem Source Type: research

Reaction mechanism of lysyl oxidase-like 2 (LOXL2) studied by computational methods.
This study is divided into two parts, i.e. the biosynthesis of lysine tyrosylquinone (LTQ) cofactor and oxidative deamination of ε-amino group of lysine by LTQ. For the former part, the reaction is driven by a large exothermicity of about 284 kJ/mol. Dopaquinone radical (DPQr) is suggested to be an intermediate state in this reaction. In addition, His652 residue is predicted to serve as proton acceptor. The rate-determining step for the biosynthesis of LTQ is found to be hydrogen-atom abstraction from the benzene ring on substrate by Cu2+-hydroxide, which is a proton-coupled electron transfer (PCET) process wi...
Source: Journal of Inorganic Biochemistry - July 27, 2020 Category: Biochemistry Authors: Dong G, Lin LR, Xu LY, Li EM Tags: J Inorg Biochem Source Type: research

Synthesis, characterization and in vitro biological evaluation of novel organotin(IV) compounds with derivatives of 2-(5-arylidene-2,4-dioxothiazolidin-3-yl)propanoic acid.
Abstract Two novel triphenyltin(IV) compounds, [Ph3SnL1] (L1 = 2-(5-(4-fluorobenzylidene)-2,4-dioxotetrahydrothiazole-3-yl)propanoate (1)) and [Ph3SnL2] (L2 = 2-(5-(5-methyl-2-furfurylidene)-2,4-dioxotetrahydrothiazole-3-yl)propanoate (2)) were synthesized and characterized by FT-IR, (1H and 13C) NMR spectroscopy, mass spectrometry, and elemental microanalysis. The in vitro anticancer activity of the synthesized organotin(IV) compounds was determined against four tumor cell lines: PC-3 (prostate), HT-29 (colon), MCF-7 (breast), and HepG2 (hepatic) using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-12 diphenyltetr...
Source: Journal of Inorganic Biochemistry - July 26, 2020 Category: Biochemistry Authors: Pantelić NĐ, Zmejkovski BB, Božić B, Dojčinović B, Banjac NR, Wessjohann LA, Kaluđerović GN Tags: J Inorg Biochem Source Type: research

Structure and reactivity of chlorite dismutase nitrosyls.
Abstract Ferric nitrosyl ({FeNO}6) and ferrous nitrosyl ({FeNO}7) complexes of the chlorite dismutases (Cld) from Klebsiella pneumoniae and Dechloromonas aromatica have been characterized using UV-visible absorbance and Soret-excited resonance Raman spectroscopy. Both of these Clds form kinetically stable {FeNO}6 complexes and they occupy a unique region of ν(Fe-NO)/ν(N-O) correlation space for proximal histidine liganded heme proteins, characteristic of weak Fe-NO and N-O bonds. This location is attributed to admixed FeIII-NO character of the {FeNO}6 ground state. Cld {FeNO}6 complexes undergo slow reductiv...
Source: Journal of Inorganic Biochemistry - July 26, 2020 Category: Biochemistry Authors: Geeraerts Z, Heskin AK, DuBois J, Rodgers KR, Lukat-Rodgers GS Tags: J Inorg Biochem Source Type: research

Binuclear Ni(II) complexes containing ONS donor Schiff base ligands: Preparation, spectral characterization, X-ray crystallography and biological exploration.
Abstract Four binuclear Ni(II) complexes [[Ni2(H-DEAsal-tsc)2(μ-dppm)]·2Cl (1), [Ni2(DEAsal-mtsc)2(μ-dppm)] (2), [Ni2(DEAsal-etsc)2(μ-dppm)] (3) and [Ni2(DEAsal-ptsc)2(μ-dppm)] (4)] were synthesized from the ligands namely 4(N,N)-diethylaminosalicylaldehyde-4(N)-thiosemicarbazone [H2-DEAsal-tsc] H2L1/4(N,N)-diethylaminosalicylaldehyde-4(N)-methyl thiosemicarbazone [H2-DEAsal-mtsc] H2L2/4(N,N)-diethylaminosalicylaldehyde-4(N)-ethyl thiosemicarbazone [H2-DEAsal-etsc] H2L3/4(N,N)diethylaminosalicylaldehyde-4(N)-phenyl thiosemicarbazone [H2-DEAsal-ptsc] H2L4 and 1,1'-bis(diphenylphosphino)methane (d...
Source: Journal of Inorganic Biochemistry - July 18, 2020 Category: Biochemistry Authors: Kalaiarasi G, Dharani S, Rajkumar SRJ, Lynch VM, Prabhakaran R Tags: J Inorg Biochem Source Type: research

Zn(II) complexes of (E)-4-(2-(pyridin-2-ylmethylene)hydrazinyl)quinazoline in combination with non-steroidal anti-inflammatory drug sodium diclofenac: Structure, DNA binding and photo-cleavage studies, antioxidant activity and interaction with albumin.
Abstract The interaction of the novel quinazoline (E)-4-(2-(pyridin-2-ylmethylene)hydrazinyl)quinazoline (L) with Zn2+ was performed in the absence or presence of the non-steroidal anti-inflammatory drug sodium diclofenac (Nadicl) and resulted in the formation of complexes [Zn(L)2](NO3)2·MeOH (1·MeOH) and [Zn(L)(dicl-O)2]·MeOH (2·MeOH), respectively. The two complexes were characterized by IR and 1H NMR spectroscopy and by single-crystal X-ray crystallography. In these complexes, L was tridentately coordinated to Zn(II) via the quinazoline, hydrazone and pyridine nitrogen atoms. Further...
Source: Journal of Inorganic Biochemistry - July 18, 2020 Category: Biochemistry Authors: Kakoulidou C, Gritzapis PS, Hatzidimitriou AG, Fylaktakidou KC, Psomas G Tags: J Inorg Biochem Source Type: research

Modulation of relaxation activity of human topoisomerases by Pt(II)-based complexes.
Abstract The clinical efficiency of Pt(II)-based drugs is founded on articulate mechanisms of action. Indeed it depends on a balanced combination of metal ion reactivity towards proteins and nucleic acids. Here we analysed the effect of two trans-platinum planar amines in comparison to cisplatin and transplatin on the DNA processivity by human topoisomerases I and IIα. Each tested metal complex produces DNA adducts with unique geometrical features and, consistently, they exert different effects on the activity of tested enzymes. Moreover, our results highlighted more subtle consequences on the enzymatic acti...
Source: Journal of Inorganic Biochemistry - July 17, 2020 Category: Biochemistry Authors: Pinato O, Benettazzo A, Dalla Via L, Farrell NP, Sissi C Tags: J Inorg Biochem Source Type: research

Theoretical characterization of Al(III) binding to KSPVPKSPVEEKG: Insights into the propensity of aluminum to interact with key sequences for neurofilament formation.
Abstract Classical molecular dynamic simulations and density functional theory are used to unveil the interaction of aluminum with various phosphorylated derivatives of the fragment KSPVPKSPVEEKG (NF13), a major multiphosphorylation domain of human neurofilament medium (NFM). Our calculations reveal the rich coordination chemistry of the resultant structures with a clear tendency of aluminum to form multidentate structures, acting as a bridging agent between different sidechains and altering the local secondary structure around the binding site. Our evaluation of binding energies allows us to determine that phosph...
Source: Journal of Inorganic Biochemistry - July 9, 2020 Category: Biochemistry Authors: Grande-Aztatzi R, Formoso E, Mujika JI, de Sancho D, Lopez X Tags: J Inorg Biochem Source Type: research

In anemia zinc is recruited from bone and plasma to produce new red blood cells.
Abstract Anemia is highly prevalent in people with chronic kidney disease (CKD), and CKD patients always have lower plasma but higher erythrocyte Zn levels than healthy people. To date, no satisfactory mechanism has explained these Zn metabolism abnormalities. We collected blood samples from patients on hemodialysis, 5/6 nephrectomized rats and phenylhydrazine (PHZ)-induced anemic mice and rats and compared them with their normal counterparts. We found that all the anemic animals had significantly decreased plasma Zn levels but elevated erythrocyte Zn levels. We also found that in anemic mice, new red blood cells ...
Source: Journal of Inorganic Biochemistry - July 4, 2020 Category: Biochemistry Authors: Chen YH, Jeng SS, Hsu YC, Liao YM, Wang YX, Cao X, Huang LJ Tags: J Inorg Biochem Source Type: research

Silver complexes with heterocyclic thioamide and tertiary arylphosphane ligands: Synthesis, crystal structures, in vitro and in silico antibacterial and cytotoxic activity, and interaction with DNA.
Abstract Herein we report on the synthesis and molecular structures of six silver(I) mixed-ligand complexes containing a heterocyclic thioamide [4-phenyl-imidazole-2-thione (phimtH) or 2,2,5,5-tetramethyl-imidazolidine-4-thione (tmimdtH)] and a tertiary arylphosphane [triphenylphosphine (PPh3), tri-o-tolylphosphane (totp)] or diphosphane [(1,2-bis(diphenylphosphano)ethane (dppe), bis(2-diphenylphosphano-phenyl)ether (DPEphos) or 4,5-bis(diphenylphosphano)-9,9-dimethylxanthene) (xantphos)]. The interaction of the compounds with calf-thymus DNA (CT DNA), as monitored directly via UV-vis spectroscopy and DNA-viscosit...
Source: Journal of Inorganic Biochemistry - July 4, 2020 Category: Biochemistry Authors: Anastasiadou D, Geromichalou E, Tsavea E, Psomas G, Hatzidimitriou AG, Kalogiannis S, Geromichalos G, Trafalis D, Dalezis P, Aslanidis P Tags: J Inorg Biochem Source Type: research

Development, evaluation and effect of anionic co-ligand on the biological activity of benzothiazole derived copper(II) complexes.
Abstract Research on development of novel metal based anti-cancer agents continues with its popularity among bioinorganic community. Benzothiazole, an important heterocyclic pharmacophore, was chosen as a valuable and useful scaffold for the synthesis of novel copper(II) complexes. Three new copper(II) complexes obtained from the synthesis of newly synthesized benzothiazole based N-(benzo[d]thiazol-2-ylmethyl)-N-methyl-2-(pyridin-2-yl)ethan-1-amine (btzpy) ligand with CuCl2 [Cu(btzpy)Cl2] (1), Cu(NCS)2 [Cu(btzpy)(NCS)2] (2), and Cu(NO3)2 [Cu(btzpy)(NO3)(H2O)]NO3 (3) were isolated and characterized by physical and ...
Source: Journal of Inorganic Biochemistry - July 3, 2020 Category: Biochemistry Authors: Jain S, Bhar K, Bandyopadhayaya S, Singh VK, Mandal CC, Tapryal S, Sharma AK Tags: J Inorg Biochem Source Type: research

In vitro biological evaluation and consideration about structure-activity relationship of silver(I) aminoacidate complexes.
acute;ková P, Hudecová D, Kello M, Vargová Z Abstract Two silver(I) aminoacidate complexes {[Ag4(L-HAla)4(NO3)3]NO3}n (AgAla, complex 1, Ala = alanine) and {[Ag(L-Phe)]}n (AgPhe, complex 2, Phe = phenylalanine) were prepared and characterized by elemental, spectral analysis (FT-IR, NMR techniques) and single crystal X-ray analysis in solid state and their solution stability was measured in biological testing time-scale by 1H NMR. The bridging coordination modes of the zwitterionic Ala and deprotonated Phe ligands led to the formation of 1D polymeric chains of the complexes. The signifi...
Source: Journal of Inorganic Biochemistry - July 3, 2020 Category: Biochemistry Authors: Kuzderová G, Rendošová M, Gyepes R, Almáši M, Sabolová D, Vilková M, Olejníková P, Hudecová D, Kello M, Vargová Z Tags: J Inorg Biochem Source Type: research

Stabilization of an intermolecular RNA triplex by two novel binders Lys- and Arg-rich Ru(II) polypyridyl metallopeptides.
Abstract In this work, using [Ru(bpy)2(pip)]2+ (bpy = 2,2'-bipyridine, pip = 2-phenyl-1H-imidazo[4,5-f]-[1,10]-phenanthroline) as chromophores and neutral amino acid glycine as spacers, two novel Arg- and Lys-rich Ru(II) polypyridyl metallopeptides as an intermolecular triplex RNA stabilizers, namely [Ru(bpy)2(pic-Lys2-Gly-Lys2-Gly-Lys2)]8+ (Ru1; pic = 2-(4-carboxy-phenyl)imidazo-[4,5-f] [1,10] phenanthroline, Gly = glycine, Lys = lysine) and [Ru(bpy)2(pic-Arg2-Gly-Arg2-Gly-Arg2)]8+ (Ru2; Arg = arginine), have been synthesized and characterized. The bindi...
Source: Journal of Inorganic Biochemistry - July 3, 2020 Category: Biochemistry Authors: Zhu J, Wang F, Liu X, Tan L Tags: J Inorg Biochem Source Type: research

Synthesis and enhanced antioxidant and membrane-protective activity of curcumin@AlOOH nanoparticles.
Abstract The ever increasing demand for nanoantioxidants with minimized toxicity dictates the necessity to develop new biocompatible materials. One promising approach is the immobilization of polyphenols on metal (oxy)hydroxide nanoparticles (NPs) that possess the desired chemical and colloidal stability while also allowing to dispose of the antioxidants more safely and effectively. In this paper we modify sol-gel synthesized γ-AlOOH NPs with curcumin molecules. The prepared colloidal systems are hydrosols, stable in acidic, neutral and slightly basic pH values. UV-vis and FTIR spectroscopies suggest that th...
Source: Journal of Inorganic Biochemistry - July 2, 2020 Category: Biochemistry Authors: Martakov IS, Shevchenko OG Tags: J Inorg Biochem Source Type: research

Synthesis, characterization, antimicrobial and cytotoxic activity of novel half-sandwich Ru(II) arene complexes with benzoylthiourea derivatives.
pka S Abstract Three new ruthenium(II)-arene complexes, [Ru(η6-p-cymene)(L1)Cl2] (C1) where L1 is N-((4 methoxyphenyl)carbamothioyl)benzamide; [Ru(η6-p-cymene)(L2)Cl2] (C2) where L2 is 4-(3-benzoylthioureido)benzoic acid and [Ru(η6-p-cymene)(L3)Cl2] (C3) where L3 is methyl 4-(3- benzoylthioureido)benzoate have been synthetized, characterized and evaluated for their antimicrobial and anticancer activity. Characterization was performed using 1H and 13C NMR, IR spectroscopy, mass spectrometry, electrical conductivity measurements and X-Ray diffraction analysis. X-Ray diffraction analysis of C1 showed typi...
Source: Journal of Inorganic Biochemistry - June 26, 2020 Category: Biochemistry Authors: Obradović D, Nikolić S, Milenković I, Milenković M, Jovanović P, Savić V, Roller A, Đorđić Crnogorac M, Stanojković T, Grgurić-Šipka S Tags: J Inorg Biochem Source Type: research

Silver nanoparticle-base lateral flow immunoassay for rapid detection of Staphylococcal enterotoxin B in milk and honey.
Abstract A silver nanoparticle (AgNP)-based sandwich-type lateral flow immunoassay (LFIA) was evaluated for rapid detection of Staphylococcal enterotoxin B (SEB) in milk and honey. The role of trisodium citrate dihydrate (TSC) in the formation of Ag/TSC nanoparticles was established using UV-Vis spectroscopy. The association of silver with TSC in Ag/TSC nanoparticles was studied by the decrease in the intensity of anodic peak potential at 0.47 V and shift to 0.30 V in cyclic voltammetry (CV). The morphological, compositional and interaction studies of the AgNPs conjugated with the anti-SEB polyclonal ant...
Source: Journal of Inorganic Biochemistry - June 24, 2020 Category: Biochemistry Authors: Wu KH, Huang WC, Shyu RH, Chang SC Tags: J Inorg Biochem Source Type: research

Metallation pathway of a plant metallothionein: Cicer arietinum MT2.
In this study the metallation pathway of cicMT2 is investigated using mass spectrometry. To evaluate the influence of the linker region as well as the interplay of the two Cys-rich stretches, the full-length cicMT2 protein as well as the individual Cys-rich domains with and without the linker region were analysed. Up to three CdII ions can be coordinated by the eight Cys residues of the N-terminal part and up to two CdII ions by the six Cys residues of the C-terminal sequence. However, no preferential binding to either of the two sequences is observed, which is in-line with the closely similar apparent binding constants of...
Source: Journal of Inorganic Biochemistry - June 24, 2020 Category: Biochemistry Authors: Salim A, Chesnov S, Freisinger E Tags: J Inorg Biochem Source Type: research

Protein dynamics of [Cu-Zn] superoxide dismutase (SOD1): How protein motions at the global and local levels impact the reactivity of SOD1.
Abstract This work explores the pivotal role that protein mobility plays in facilitating the catalytic activity of Copper-Zinc superoxide dismutase (SOD1). Through both localized active site distortions and correlated domain movement, these motions enable the enzyme to adopt the conformations necessary to achieve both substrate delivery and efficient catalytic transformation. Structural and computational studies of a biomimetic model complex are used to probe the localized interactions between substrate and secondary sphere residues that play a role in guiding substrate to the active site, as well as facilitating ...
Source: Journal of Inorganic Biochemistry - June 24, 2020 Category: Biochemistry Authors: Healy EF, Flores R, Lynch VM, Toledo S Tags: J Inorg Biochem Source Type: research

A divergent mode of activation of a nitrosyl iron complex with unusual antiangiogenic activity.
, Lopes LGF Abstract Nitric oxide (NO) and nitroxyl (HNO) have gained broad attention due to their roles in several physiological and pathophysiological processes. Remarkably, these sibling species can exhibit opposing effects including the promotion of angiogenic activity by NO compared to HNO, which blocks neovascularization. While many NO donors have been developed over the years, interest in HNO has led to the recent emergence of new donors. However, in both cases there is an expressive lack of iron-based compounds. Herein, we explored the novel chemical reactivity and stability of the trans-[Fe(cyclam)(NO)Cl]...
Source: Journal of Inorganic Biochemistry - June 20, 2020 Category: Biochemistry Authors: Carvalho EM, Ridnour LA, Júnior FSG, Cabral PHB, do Nascimento NRF, Wink DA, Franco DW, de Medeiros MJC, de Lima Pontes D, Longhinotti E, de Freitas Paulo T, Bernardes-Génisson V, Chauvin R, Sousa EHS, Lopes LGF Tags: J Inorg Biochem Source Type: research

Corrigendum to "Evaluation of the cell cytotoxicity and DNA/BSA binding and cleavage activity of some dioxidovanadium(V) complexes containing aroylhydrazones" [J. Inorg. Biochem. 144 (2015) 1-12].
Corrigendum to "Evaluation of the cell cytotoxicity and DNA/BSA binding and cleavage activity of some dioxidovanadium(V) complexes containing aroylhydrazones" [J. Inorg. Biochem. 144 (2015) 1-12]. J Inorg Biochem. 2020 Jun 19;210:111135 Authors: Dash SP, Panda AK, Pasayat S, Majumder S, Biswas A, Kaminsky W, Mukhopadhyay S, Bhutia SK, Dinda R PMID: 32569883 [PubMed - as supplied by publisher] (Source: Journal of Inorganic Biochemistry)
Source: Journal of Inorganic Biochemistry - June 19, 2020 Category: Biochemistry Authors: Dash SP, Panda AK, Pasayat S, Majumder S, Biswas A, Kaminsky W, Mukhopadhyay S, Bhutia SK, Dinda R Tags: J Inorg Biochem Source Type: research

Synthesis, molecular structure and antioxidant activity of bis [L( μ2-chloro)copper(II)] supported by phenoxy/naphthoxy-imine ligands.
Synthesis, molecular structure and antioxidant activity of bis [L(μ2-chloro)copper(II)] supported by phenoxy/naphthoxy-imine ligands. J Inorg Biochem. 2020 Jun 11;210:111130 Authors: Dos Santos TM, Martins CC, Bueno DT, Nunes IJ, Busatto FF, Cargnelutti R, Luchese C, de Lazaro Casagrande O, Saffi J, Wilhelm EA, Pinheiro AC Abstract A new series of Cu(II) complexes [bis[{(μ2-chloro)-2-MeO-Ph-CH2-(N=CH)-2,4-tert-butyl-2-OC6H2)}Cu(II)] (Cu1); bis[{(μ2-chloro)-2-MeS-Ph-CH2-(N=CH)-2,4-tert-butyl-2-(OC6H2)}Cu(II)] (Cu2); bis[{(μ2-chloro)-2-MeO-Ph-CH2-(N=CH)-2-(OC10H6)} Cu(II)] (Cu3); bis[{(μ2...
Source: Journal of Inorganic Biochemistry - June 11, 2020 Category: Biochemistry Authors: Dos Santos TM, Martins CC, Bueno DT, Nunes IJ, Busatto FF, Cargnelutti R, Luchese C, de Lazaro Casagrande O, Saffi J, Wilhelm EA, Pinheiro AC Tags: J Inorg Biochem Source Type: research

Synthesis, characterization and in vitro antibacterial mechanism study of two Keggin-type polyoxometalates.
Abstract In this article, two Keggin-type polyoxometalates [Co(L)2]3[PMo12O40] (1) and [Co(L)2]3[PW12O40] (2) (HL = 2-acetylpyrazine thiosemicarbazone) were prepared and fully characterized. The compounds are stable in aqueous solution with different pH values and show superior antibacterial activity against Escherichia coli (E. coli: minimal inhibitory concentration (MIC) = 0.00375, 0.12 μg/mL), Agrobacterium tumefaciens (A. tumefaciens: MIC = 0.06, 0.12 μg/mL), Bacillus subtilis (B. subtilis: MIC = 0.015, 0.06 μg/mL) and especially for Staphylococcu...
Source: Journal of Inorganic Biochemistry - June 10, 2020 Category: Biochemistry Authors: Zhao M, Fang Y, Ma L, Zhu X, Jiang L, Li M, Han Q Tags: J Inorg Biochem Source Type: research

Antibacterial activity and action mode of Cu(I) and Cu(II) complexes with phosphines derived from fluoroquinolone against clinical and multidrug-resistant bacterial strains.
In conclusion, differences in PSf activity within closely related P. aeruginosa strains may indicate its diagnostic and therapeutic potential. PMID: 32534287 [PubMed - as supplied by publisher] (Source: Journal of Inorganic Biochemistry)
Source: Journal of Inorganic Biochemistry - June 2, 2020 Category: Biochemistry Authors: Guz-Regner K, Komarnicka UK, Futoma-Kołoch B, Wernecki M, Cal M, Kozieł S, Ziółkowska A, Bugla-Płoskońska G Tags: J Inorg Biochem Source Type: research

Diiron and trinuclear NiFe2 dithiolate complexes chelating by PCNCP ligands: Synthetic models of [FeFe]- and [NiFe]-hydrogenases.
Abstract To further develop the biomimetic chemistry of [FeFe]- and [NiFe]-hydrogenases for catalytic proton reduction to hydrogen (H2), two serials of dinuclear diiron and trinuclear NiFe2 dithiolate complexes with chelating PCNCP ligands, namely, Fe2(μ-edt)(CO)4{κ2-(Ph2PCH2)2NR} (1a-1c) and Fe2(CO)6(μ3-S)2Ni{(Ph2PCH2)2NR} (2a-2c) where edt = SCH2CH2S and PCNCP = (Ph2PCH2)2NR [R = Bui (CH2CHMe2), But (CMe3), and Bun (CH2CH2CH2Me)], have been synthesized in moderate yields. All the new complexes 1a-1c and 2a-2c have been fully characterized by elemental analysis, FT-IR, NM...
Source: Journal of Inorganic Biochemistry - June 2, 2020 Category: Biochemistry Authors: Zhao PH, Li JR, Gu XL, Jing XB, Liu XF Tags: J Inorg Biochem Source Type: research

The 23rd International Symposium on the Photochemistry and Photophysics of Coordination Compounds (ISPPCC 2019).
PMID: 32512347 [PubMed - as supplied by publisher] (Source: Journal of Inorganic Biochemistry)
Source: Journal of Inorganic Biochemistry - June 2, 2020 Category: Biochemistry Authors: Lo KK Tags: J Inorg Biochem Source Type: research

A simple POM clusters for in vivo NIR-II photoacoustic imaging-guided NIR-II photothermal therapy.
Abstract Photoacoustic (PA) imaging in the second near-infrared (NIR-II) window exhibits enhanced deep-tissue imaging capability. Likely, cancer therapy in the NIR-II window could provide deeper penetration depth and higher exposure to laser over NIR-I. However, the traditional application of excitation light is still in the NIR-I window. In view of the excellent imaging and therapeutic capabilities of NIR-II window, we have demonstrated a simple polyoxometalate (POM) clusters (molecular formula: (Na)n(PMo12O40) or (NH4+)n(PMo12O40)), which integrates NIR-II photoacoustic imaging and NIR-II photothermal therapy in...
Source: Journal of Inorganic Biochemistry - May 26, 2020 Category: Biochemistry Authors: Han Y, Qu B, Li J, Zhang X, Peng X, Li W, Zhang R Tags: J Inorg Biochem Source Type: research

Cytotoxicity of Mn-based photoCORMs of ethynyl- α-diimine ligands against different cancer cell lines: The key role of CO-depleted metal fragments.
Cytotoxicity of Mn-based photoCORMs of ethynyl-α-diimine ligands against different cancer cell lines: The key role of CO-depleted metal fragments. J Inorg Biochem. 2020 May 26;209:111122 Authors: Rossier J, Delasoie J, Haeni L, Hauser D, Rothen-Rutishauser B, Zobi F Abstract A series of tricarbonyl manganese complexes bearing 4-ethynyl-2,2'-bipyridine and 5-ethynyl-1,10-phenanthroline α-diimine ligands were synthetized, characterized and conjugated to vitamin B12, previously used as a vector for drug delivery, to take advantage of its water solubility and specificity toward cancer cells. T...
Source: Journal of Inorganic Biochemistry - May 26, 2020 Category: Biochemistry Authors: Rossier J, Delasoie J, Haeni L, Hauser D, Rothen-Rutishauser B, Zobi F Tags: J Inorg Biochem Source Type: research

A luminescent europium hairpin for DNA photosensing in the visible, based on trimetallic bis-intercalators.
We report herein a luminescent hetero-trimetallic complex with europium as a luminescent reporter and two attached platinum acetylide terpyridyl units as the DNA recognition units. The ligand, based on a bisamide derivative of diethylenetriaminepentaacetic acid functionalized with two ethynyl groups, provides a backbone to anchor two platinum terpyridyl units, Pt-tpy, leading to the hairpin-shaped heterometallic complex 1. We also prepared a related mono-nuclear platinum complex 2 to compare its intercalation properties with 1. Linear dichroism, UV-visible and melting experiments show the ability of both complexes to inter...
Source: Journal of Inorganic Biochemistry - May 23, 2020 Category: Biochemistry Authors: Scarpantonio L, Cotton SA, Del Giorgio E, McCallum M, Hannon MJ, Pikramenou Z Tags: J Inorg Biochem Source Type: research

Cyclometalated iridium(III) complexes containing an anthracene unit for sensing and imaging singlet oxygen in cellular mitochondria.
Abstract Singlet oxygen (1O2), as a highly reactive oxygen species, plays an important role in the physical, chemical and biomedical fields, especially during photodynamic therapy (PDT) process. In this work, two iridium(III) complexes containing an anthracene unit in their diimine ligand were designed and synthesized to monitor 1O2 in living cells. The complexes were weakly emissive owing to the photoinduced electron transfer process, but exhibited intense luminescence upon capturing 1O2, resulting from the formation of the corresponding endoperoxide analogues. The remarkable turn-on luminescence response was spe...
Source: Journal of Inorganic Biochemistry - May 22, 2020 Category: Biochemistry Authors: Liu X, Dai P, Gu T, Wu Q, Wei H, Liu S, Zhang KY, Zhao Q Tags: J Inorg Biochem Source Type: research

Conformational selection is present in ligand binding to cytochrome P450 19A1 lipoprotein nanodiscs.
Hackett JC Abstract Cytochromes P450 (CYPs) display remarkable plasticity in their ability to bind substrates and catalyze a broad array of chemical reactions. Herein we evaluate binding of androstenedione, testosterone, and 7-hydroxyflavone to CYP19A1, also known as aromatase, in phospholipid nanodiscs by stopped-flow UV-vis spectroscopy. Exponential fitting of the kinetic traces supports the possibility of a multi-step binding mechanism. Subsequent global fitting of the data to the solutions of the coupled differential equations describing the fundamental mechanisms of induced fit and conformational selection, ...
Source: Journal of Inorganic Biochemistry - May 21, 2020 Category: Biochemistry Authors: Zárate-Pérez F, Hackett JC Tags: J Inorg Biochem Source Type: research

Antiparasitic, anti-inflammatory and cytotoxic activities of 2D coordination polymers based on 1H-indazole-5-carboxylic acid.
We report on the formation of two novel multifunctional isomorphous (4,4) square-grid 2D coordination polymers based on 1H-indazole-5-carboxylic acid. To the best of our knowledge, these complexes are the first examples of 2D-coordination polymers constructed with this novel ligand. We have analysed in detail the structural, magnetic and anti-parasitic properties of the resulting materials. In addition, the capability of inhibiting nitric oxide production from macrophage cells has been measured and was used as an indirect measure of the anti-inflammatory response. Finally, the photocatalytic activity was measured with a mo...
Source: Journal of Inorganic Biochemistry - May 18, 2020 Category: Biochemistry Authors: García-Valdivia AA, García-García A, Jannus F, Zabala-Lekuona A, Méndez-Arriaga JM, Fernández B, Medina-O'donnell M, Ramírez-Rodríguez GB, Delgado-López JM, Pastrana-Martínez LM, Cepeda J, Lupiáñez JA, Reyes-Zurita FJ, Rodríguez-Diéguez A Tags: J Inorg Biochem Source Type: research

Photo-activated CO-release in the amino tungsten Fischer carbene complex, [(CO)5WC(NC4H8)Me], picosecond time resolved infrared spectroscopy, time-dependent density functional theory, and an antimicrobial study.
Abstract Picosecond time-resolved infrared spectroscopy was used to probe the photo-induced early state dynamics preceding CO loss in the Fischer carbene complex, [(CO)5WC(NC4H8)CH3]. Time-dependent density functional theory calculations were employed to help in understanding the photochemical and photophysical processes leading to CO-loss. Electrochemical initiated CO release was quantified using gas chromatography. The potential of [(CO)5WC(NC4H8)CH3], as an antimicrobial agent under irradiation conditions was studied using a Staphylococcus aureus strain. PMID: 32434119 [PubMed - as supplied by publisher] (...
Source: Journal of Inorganic Biochemistry - May 7, 2020 Category: Biochemistry Authors: McMahon S, Rajagopal A, Amirjalayer S, Halpin Y, Fitzgerald-Hughes D, Buma WJ, Woutersen S, Long C, Pryce MT Tags: J Inorg Biochem Source Type: research

New in vitro highly cytotoxic platinum and palladium cyanoximates with minimal side effects in vivo.
Abstract Several biologically active bivalent Pd and Pt complexes with two structurally similar cyanoxime ligands abbreviated as H(DECO): 2-oximino-2-cyano-N,N'-diethylacetamide, and H(PyrCO): 2-oximino-2-cyan-N-pyrrolidine acetamide were synthesized and characterized using spectroscopic methods, thermal analysis and X-ray crystallography. Structures revealed planar cis-geometry of studied complexes. Freshly obtained Pt(DECO)2, Pd(DECO)2, Pt(PyrCO)2 and Pd(PyrCO)2 complexes were used in for in vitro cytotoxicity assays using two different etiology human cancer cell lines HeLa and WiDr cells. Investigated compounds...
Source: Journal of Inorganic Biochemistry - May 6, 2020 Category: Biochemistry Authors: Dannen SD, Cornelison L, Durham P, Morley JE, Shahverdi K, Du J, Zhou H, Sudlow LC, Hunter D, Wood MD, Berezin MY, Gerasimchuk N Tags: J Inorg Biochem Source Type: research

Anti-adhesive action of novel ruthenium(II) chlorophenyl terpyridine complexes with a high affinity for double-stranded DNA: in vitro and in silico.
Abstract Interactions of three Ru(II) chlorophenyl terpyridine complexes: [Ru(Cl-Ph-tpy)(en)Cl]Cl (1), [Ru(Cl-Ph-tpy)(dach)Cl]Cl (2) and [Ru(Cl-Ph-tpy)(bpy)Cl]Cl (3) (Cl-Ph-tpy = 4'-(4-chlorophenyl)-2,2':6',2''-terpyridine, en = 1,2-diaminoethane, dach = 1,2-diaminocyclohexane, bpy = 2,2'-bipyridine) with human serum albumin (HSA), calf thymus DNA and a double-helical oligonucleotide d(CGCGAATTCGCG)2 (1BNA) were examined. Fluorescence emission studies were used to assess the interactions of complexes with HSA, which were of moderate strength for 1 and 2. Molecular docking al...
Source: Journal of Inorganic Biochemistry - April 28, 2020 Category: Biochemistry Authors: Masnikosa R, Milutinović MM, Crnolatac I, Tot A, Veličković S, Bojić-Trbojević Ž, Rilak-Simović A Tags: J Inorg Biochem Source Type: research

Novel bidentate oxovanadium(IV) glycolate, α-hydroxybutyrate and citrate with terpyridine and their conversions to nitrosyl products.
Novel bidentate oxovanadium(IV) glycolate, α-hydroxybutyrate and citrate with terpyridine and their conversions to nitrosyl products. J Inorg Biochem. 2020 Apr 23;208:111086 Authors: Jin WT, Zhou ZH Abstract A series of monomeric α-hydroxycarboxylato oxovanadium(IV) complexes [VO(H2cit)(tpy)]·H2O (1) (H4cit = citric acid, tpy = 2,2':6',2-terpyridine), [VO(glyc)(tpy)]·5.5H2O (2) (H2glyc = glycolic acid) and [VO(α-hbut)(tpy)]·3H2O (3) (α-H2hbut = α-hydroxybutyratic acid) have been obtained from the reactions of va...
Source: Journal of Inorganic Biochemistry - April 23, 2020 Category: Biochemistry Authors: Jin WT, Zhou ZH Tags: J Inorg Biochem Source Type: research

Light activation of cyclometalated ruthenium complexes drives towards caspase 3 dependent apoptosis in gastric cancer cells.
e Lagadec R Abstract Polypyridyl ruthenium complexes have been intensively investigated for their remarkable antiproliferative properties and some are currently being tested in clinical trials. Here, we investigated the impact of illumination on the biological properties of a series of new cyclometalated ruthenium compounds with increased π-conjugation. We determined that various of these complexes display a bivalent biological activity as they are highly cytotoxic by themselves in absence of light while their cytotoxicity can significantly be elevated towards an IC50 in the nanomolar range upon illumination. I...
Source: Journal of Inorganic Biochemistry - March 28, 2020 Category: Biochemistry Authors: Solís-Ruiz JA, Barthe A, Riegel G, Saavedra-Díaz RO, Gaiddon C, Le Lagadec R Tags: J Inorg Biochem Source Type: research

Construction of hybrid DNAs@CP for the rapid synchronous sensing of multiplex microRNAs based on experimental studies and molecular simulation.
Abstract A water stable one-dimensional (1D) ladder-shaped coordination polymer (CP) has been synthesized and exhibits a strong affinity to two fluorescein-tagged single-stranded probe DNAs (P-DNAs), giving a sensing platform of P-DNAs@1. Such a hybrid sensing platform is capable of simultaneous detection of breast cancer related microRNA-221 (miRNA-221) and miRNA-222 in a specific and synchronous manner, without observable cross-reactions, as supported by experimental evidences. The interaction mode and the electronic energy between CP 1 with nucleic acid were confirmed by molecular simulation and the universal f...
Source: Journal of Inorganic Biochemistry - March 23, 2020 Category: Biochemistry Authors: Yang ZC, Wang TR, Li RT, Chen TW, Fan Y, Jiang WH, Li MM, Chen JX Tags: J Inorg Biochem Source Type: research