One-pot synthesis, structural investigation, antitumor activity and molecular docking approach of two decavanadate compounds
In this study, the cytotoxic and the anti-proliferative activities of compounds (1) and (2) on human cancer cells (U87 and MDA-MB-231) were investigated. Both compounds demonstrated dose-dependent anti-proliferative activity on U87 and MDA-MB-231 with respective IC50 values of 0.82 and 0.31 μM and 1.4 and 1.75 μM. These data provide evidence on the potential anticancer activity of [(C6H13N4)2][Mg(H2O)6]2[O28V10].6H2O and [(C7H11N2)4][Mg(H2O)2][O28V10].4H2O. Molecular docking of the compounds was also examined. Molecular docking studies were performed for both compounds against four target receptors and revealed better bi...
Source: Journal of Inorganic Biochemistry - March 28, 2024 Category: Biochemistry Authors: Rihab Dridi Zaineb Abdelkafi-Koubaa Najet Srairi-Abid Bhavesh Socha Mohamed Faouzi Zid Source Type: research
Copper perchlorate catalyzed oxidative cyclisation of a novel bishydrazone ligand, formation of an unusual copper complex and in vitro biological implications
J Inorg Biochem. 2024 Mar 22;255:112538. doi: 10.1016/j.jinorgbio.2024.112538. Online ahead of print.ABSTRACTA novel hexadentate bishydrazone ligand, 1,10-bis(di(2-pyridyl)ketone) adipic acid dihydrazone (H2L1) is synthesized and characterized. With copper perchlorate as a catalytic oxidant, the ligand undergoes oxidative cyclisation and resulted in the formation of an unusual copper complex [Cu(L1a)2Cl]ClO4 (1), where L1a is 3-(2-pyridyl)triazolo[1,5-a]-pyridine. The Cu(II) complex was characterized physicochemically, while the molecular structure was confirmed by single crystal X- ray diffraction. In the complex cation, ...
Source: Journal of Inorganic Biochemistry - March 28, 2024 Category: Biochemistry Authors: Lakshmi V Menon E Manoj Source Type: research
Regulations of mitoNEET by the key redox homeostasis molecule glutathione
J Inorg Biochem. 2024 Mar 20;255:112535. doi: 10.1016/j.jinorgbio.2024.112535. Online ahead of print.ABSTRACTHuman mitoNEET (mNT) and CISD2 are two NEET proteins characterized by an atypical [2Fe-2S] cluster coordination involving three cysteines and one histidine. They act as redox switches with an active state linked to the oxidation of their cluster. In the present study, we show that reduced glutathione but also free thiol-containing molecules such as β-mercaptoethanol can induce a loss of the mNT cluster under aerobic conditions, while CISD2 cluster appears more resistant. This disassembly occurs through a radical-ba...
Source: Journal of Inorganic Biochemistry - March 25, 2024 Category: Biochemistry Authors: C écile Mons Myriam Salameh Thomas Botzanowski Martin Cl émancey Pierre Dorlet Cindy Valli ères St éphane Erb Laurence Vernis Olivier Guittet Michel Lepoivre Meng-Er Huang Sarah Cianferani Jean-Marc Latour Genevi ève Blondin Marie-Pierre Golinelli-Co Source Type: research
Regulations of mitoNEET by the key redox homeostasis molecule glutathione
J Inorg Biochem. 2024 Mar 20;255:112535. doi: 10.1016/j.jinorgbio.2024.112535. Online ahead of print.ABSTRACTHuman mitoNEET (mNT) and CISD2 are two NEET proteins characterized by an atypical [2Fe-2S] cluster coordination involving three cysteines and one histidine. They act as redox switches with an active state linked to the oxidation of their cluster. In the present study, we show that reduced glutathione but also free thiol-containing molecules such as β-mercaptoethanol can induce a loss of the mNT cluster under aerobic conditions, while CISD2 cluster appears more resistant. This disassembly occurs through a radical-ba...
Source: Journal of Inorganic Biochemistry - March 25, 2024 Category: Biochemistry Authors: C écile Mons Myriam Salameh Thomas Botzanowski Martin Cl émancey Pierre Dorlet Cindy Valli ères St éphane Erb Laurence Vernis Olivier Guittet Michel Lepoivre Meng-Er Huang Sarah Cianferani Jean-Marc Latour Genevi ève Blondin Marie-Pierre Golinelli-Co Source Type: research
Regulations of mitoNEET by the key redox homeostasis molecule glutathione
J Inorg Biochem. 2024 Mar 20;255:112535. doi: 10.1016/j.jinorgbio.2024.112535. Online ahead of print.ABSTRACTHuman mitoNEET (mNT) and CISD2 are two NEET proteins characterized by an atypical [2Fe-2S] cluster coordination involving three cysteines and one histidine. They act as redox switches with an active state linked to the oxidation of their cluster. In the present study, we show that reduced glutathione but also free thiol-containing molecules such as β-mercaptoethanol can induce a loss of the mNT cluster under aerobic conditions, while CISD2 cluster appears more resistant. This disassembly occurs through a radical-ba...
Source: Journal of Inorganic Biochemistry - March 25, 2024 Category: Biochemistry Authors: C écile Mons Myriam Salameh Thomas Botzanowski Martin Cl émancey Pierre Dorlet Cindy Valli ères St éphane Erb Laurence Vernis Olivier Guittet Michel Lepoivre Meng-Er Huang Sarah Cianferani Jean-Marc Latour Genevi ève Blondin Marie-Pierre Golinelli-Co Source Type: research
Antifungal activity of ruthenium (II) complex combined with fluconazole against drug-resistant Candida albicans in vitro and its anti-invasive infection in vivo
J Inorg Biochem. 2024 Mar 12;255:112522. doi: 10.1016/j.jinorgbio.2024.112522. Online ahead of print.ABSTRACTWith the abuse of antibiotics and azoles, drug-resistant Candida albicans infections have increased sharply and are spreading rapidly, thereby significantly reducing the antifungal efficacy of existing therapeutics. Several patients die of fungal infections every year. Therefore, there is an urgent requirement to develop new drugs. Accordingly, we synthesized a series of polypyridyl ruthenium (II) complexes having the formula [Ru (NN)2 (bpm)] (PF6)2 (N-N = 2,2'-bipyridine) (bpy, in Ru1), 1,10-phenanthroline (phen, i...
Source: Journal of Inorganic Biochemistry - March 24, 2024 Category: Biochemistry Authors: Zhi-Chang Xu Xiu-Rong Ma Li-Juan Zhang Hui-Ting Chen Ding-Mei Qing Rong-Tao Li Rui-Rong Ye Rui-Rui Wang Source Type: research
Erbium(III) complexes with fluoroquinolones: Structure and biological properties
J Inorg Biochem. 2024 Mar 15;255:112525. doi: 10.1016/j.jinorgbio.2024.112525. Online ahead of print.ABSTRACTFour erbium(III) complexes with the fluoroquinolones enrofloxacin, levofloxacin, flumequine and sparfloxacin as ligands were synthesized and characterized by a wide range of physicochemical and spectroscopic techniques as well as single-crystal X-ray crystallography. The compounds were evaluated for their activity against the bacterial strains Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Xanthomonas campestris, which was higher than that of the corresponding free quinolones. The interaction mode of...
Source: Journal of Inorganic Biochemistry - March 24, 2024 Category: Biochemistry Authors: Eleni Arnaouti Christina Georgiadou Antonios G Hatizdimitriou Stavros Kalogiannis George Psomas Source Type: research
Antifungal activity of ruthenium (II) complex combined with fluconazole against drug-resistant Candida albicans in vitro and its anti-invasive infection in vivo
J Inorg Biochem. 2024 Mar 12;255:112522. doi: 10.1016/j.jinorgbio.2024.112522. Online ahead of print.ABSTRACTWith the abuse of antibiotics and azoles, drug-resistant Candida albicans infections have increased sharply and are spreading rapidly, thereby significantly reducing the antifungal efficacy of existing therapeutics. Several patients die of fungal infections every year. Therefore, there is an urgent requirement to develop new drugs. Accordingly, we synthesized a series of polypyridyl ruthenium (II) complexes having the formula [Ru (NN)2 (bpm)] (PF6)2 (N-N = 2,2'-bipyridine) (bpy, in Ru1), 1,10-phenanthroline (phen, i...
Source: Journal of Inorganic Biochemistry - March 24, 2024 Category: Biochemistry Authors: Zhi-Chang Xu Xiu-Rong Ma Li-Juan Zhang Hui-Ting Chen Ding-Mei Qing Rong-Tao Li Rui-Rong Ye Rui-Rui Wang Source Type: research
Erbium(III) complexes with fluoroquinolones: Structure and biological properties
J Inorg Biochem. 2024 Mar 15;255:112525. doi: 10.1016/j.jinorgbio.2024.112525. Online ahead of print.ABSTRACTFour erbium(III) complexes with the fluoroquinolones enrofloxacin, levofloxacin, flumequine and sparfloxacin as ligands were synthesized and characterized by a wide range of physicochemical and spectroscopic techniques as well as single-crystal X-ray crystallography. The compounds were evaluated for their activity against the bacterial strains Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Xanthomonas campestris, which was higher than that of the corresponding free quinolones. The interaction mode of...
Source: Journal of Inorganic Biochemistry - March 24, 2024 Category: Biochemistry Authors: Eleni Arnaouti Christina Georgiadou Antonios G Hatizdimitriou Stavros Kalogiannis George Psomas Source Type: research
A new copper(II) complex containing long-chain aliphatic hydrazide and 1,10-phenanthroline upregulates ADP hydrolysis in triple-negative breast cancer cells
J Inorg Biochem. 2024 Mar 16;255:112524. doi: 10.1016/j.jinorgbio.2024.112524. Online ahead of print.ABSTRACTCopper can be opportunely complexed to modulate oncogenic pathways, being a promising strategy for cancer treatment. Herein, three new copper(II) complexes containing long-chain aliphatic hydrazides and 1,10-phenanthroline (1,10-phen), namely, [Cu(octh)(1,10-phen)(H2O)](NO3)21, [Cu(dech)(1,10-phen)(H2O)](NO3)22 and [Cu(dodh)(1,10-phen)(H2O)](NO3)2.H2O 3 (where octh = octanoic hydrazide, dech = decanoic hydrazide, dodh = dodecanoic hydrazide) were successfully prepared and characterized by several physical-chemical m...
Source: Journal of Inorganic Biochemistry - March 20, 2024 Category: Biochemistry Authors: Helen Soares Valen ça Ferreira Luana Munique Sousa Ramos Fernanda Cardoso Silva Daniel Lima Alves Gabriele de Menezes Pereira Pedro Henrique de Oliveira Santiago Angelina Maria de Almeida Javier Ellena Pedro Paulo Corbi Carolina Gon çalves Oliveira Maur Source Type: research
Tyrosine nitration of glucagon impairs its function: Extending the role of heme in T2D pathogenesis
J Inorg Biochem. 2024 Mar 12;255:112519. doi: 10.1016/j.jinorgbio.2024.112519. Online ahead of print.ABSTRACTNew studies raise the possibility that the higher glucagon (GCG) level present in type 2 diabetes (T2D) is a compensatory mechanism to enhance β-cell function, rather than induce dysregulated glucose homeostasis, due to an important role for GCG that acts directly within the pancreas on insulin secretion by intra-islet GCG signaling. However, in states of poorly controlled T2D, pancreatic α cell mass increases (overproduced GCG) in response to insufficient insulin secretion, indicating decreased local GCG activity...
Source: Journal of Inorganic Biochemistry - March 20, 2024 Category: Biochemistry Authors: Xiaoying Yin Guoqi Ni Xuan Zhang Shitao Fu Hailing Li Zhonghong Gao Source Type: research
A new copper(II) complex containing long-chain aliphatic hydrazide and 1,10-phenanthroline upregulates ADP hydrolysis in triple-negative breast cancer cells
J Inorg Biochem. 2024 Mar 16;255:112524. doi: 10.1016/j.jinorgbio.2024.112524. Online ahead of print.ABSTRACTCopper can be opportunely complexed to modulate oncogenic pathways, being a promising strategy for cancer treatment. Herein, three new copper(II) complexes containing long-chain aliphatic hydrazides and 1,10-phenanthroline (1,10-phen), namely, [Cu(octh)(1,10-phen)(H2O)](NO3)21, [Cu(dech)(1,10-phen)(H2O)](NO3)22 and [Cu(dodh)(1,10-phen)(H2O)](NO3)2.H2O 3 (where octh = octanoic hydrazide, dech = decanoic hydrazide, dodh = dodecanoic hydrazide) were successfully prepared and characterized by several physical-chemical m...
Source: Journal of Inorganic Biochemistry - March 20, 2024 Category: Biochemistry Authors: Helen Soares Valen ça Ferreira Luana Munique Sousa Ramos Fernanda Cardoso Silva Daniel Lima Alves Gabriele de Menezes Pereira Pedro Henrique de Oliveira Santiago Angelina Maria de Almeida Javier Ellena Pedro Paulo Corbi Carolina Gon çalves Oliveira Maur Source Type: research
Tyrosine nitration of glucagon impairs its function: Extending the role of heme in T2D pathogenesis
J Inorg Biochem. 2024 Mar 12;255:112519. doi: 10.1016/j.jinorgbio.2024.112519. Online ahead of print.ABSTRACTNew studies raise the possibility that the higher glucagon (GCG) level present in type 2 diabetes (T2D) is a compensatory mechanism to enhance β-cell function, rather than induce dysregulated glucose homeostasis, due to an important role for GCG that acts directly within the pancreas on insulin secretion by intra-islet GCG signaling. However, in states of poorly controlled T2D, pancreatic α cell mass increases (overproduced GCG) in response to insufficient insulin secretion, indicating decreased local GCG activity...
Source: Journal of Inorganic Biochemistry - March 20, 2024 Category: Biochemistry Authors: Xiaoying Yin Guoqi Ni Xuan Zhang Shitao Fu Hailing Li Zhonghong Gao Source Type: research
A new copper(II) complex containing long-chain aliphatic hydrazide and 1,10-phenanthroline upregulates ADP hydrolysis in triple-negative breast cancer cells
J Inorg Biochem. 2024 Mar 16;255:112524. doi: 10.1016/j.jinorgbio.2024.112524. Online ahead of print.ABSTRACTCopper can be opportunely complexed to modulate oncogenic pathways, being a promising strategy for cancer treatment. Herein, three new copper(II) complexes containing long-chain aliphatic hydrazides and 1,10-phenanthroline (1,10-phen), namely, [Cu(octh)(1,10-phen)(H2O)](NO3)21, [Cu(dech)(1,10-phen)(H2O)](NO3)22 and [Cu(dodh)(1,10-phen)(H2O)](NO3)2.H2O 3 (where octh = octanoic hydrazide, dech = decanoic hydrazide, dodh = dodecanoic hydrazide) were successfully prepared and characterized by several physical-chemical m...
Source: Journal of Inorganic Biochemistry - March 20, 2024 Category: Biochemistry Authors: Helen Soares Valen ça Ferreira Luana Munique Sousa Ramos Fernanda Cardoso Silva Daniel Lima Alves Gabriele de Menezes Pereira Pedro Henrique de Oliveira Santiago Angelina Maria de Almeida Javier Ellena Pedro Paulo Corbi Carolina Gon çalves Oliveira Maur Source Type: research
Tyrosine nitration of glucagon impairs its function: Extending the role of heme in T2D pathogenesis
J Inorg Biochem. 2024 Mar 12;255:112519. doi: 10.1016/j.jinorgbio.2024.112519. Online ahead of print.ABSTRACTNew studies raise the possibility that the higher glucagon (GCG) level present in type 2 diabetes (T2D) is a compensatory mechanism to enhance β-cell function, rather than induce dysregulated glucose homeostasis, due to an important role for GCG that acts directly within the pancreas on insulin secretion by intra-islet GCG signaling. However, in states of poorly controlled T2D, pancreatic α cell mass increases (overproduced GCG) in response to insufficient insulin secretion, indicating decreased local GCG activity...
Source: Journal of Inorganic Biochemistry - March 20, 2024 Category: Biochemistry Authors: Xiaoying Yin Guoqi Ni Xuan Zhang Shitao Fu Hailing Li Zhonghong Gao Source Type: research
