Synthesis, characterization and discovery of multiple anticancer mechanisms of dibutyltin complexes based on salen-like ligands
This study reveals new mechanisms of organotin complexes and provides new insights into the development of organotin metal complexes as anticancer drugs in the future, and compounds with multiple anticancer mechanisms may be a new strategy for delaying or overcoming drug resistance to chemotherapy and target therapy.PMID:38029537 | DOI:10.1016/j.jinorgbio.2023.112434 (Source: Journal of Inorganic Biochemistry)
Source: Journal of Inorganic Biochemistry - November 29, 2023 Category: Biochemistry Authors: Wei Tian Wen Zhong Zengyan Yang Ling Chen Shijie Lin Yanping Li Yuxing Wang Peilin Yang Xing Long Source Type: research
Gold(III) complexes with thiosemicarbazone ligands: insights into their cytotoxic effects on lung cancer cells
In this study, three gold(III) complexes derived from thiosemicarbazone ligands have been synthesized, fully characterized, including their X-ray crystal structures. We conducted initial mode-of-action studies on DNA and BSA, followed by a comprehensive investigation into the cytotoxic effects of these novel gold(III) complexes on lung cancer cells (A549, H2052, and H28). The results demonstrated a concentration-dependent cytotoxic response, with H28 cells exhibiting the highest sensitivity to the treatment. Furthermore, the analysis of the cell cycle revealed that these compounds induce cell cycle arrest and promote apopt...
Source: Journal of Inorganic Biochemistry - November 29, 2023 Category: Biochemistry Authors: Mirco Scaccaglia Silvana Pinelli Luca Manini Benedetta Ghezzi Maria Nicastro Julian Heinrich Nora Kulak Paola Mozzoni Giorgio Pelosi Franco Bisceglie Source Type: research
Synthesis, characterization and discovery of multiple anticancer mechanisms of dibutyltin complexes based on salen-like ligands
This study reveals new mechanisms of organotin complexes and provides new insights into the development of organotin metal complexes as anticancer drugs in the future, and compounds with multiple anticancer mechanisms may be a new strategy for delaying or overcoming drug resistance to chemotherapy and target therapy.PMID:38029537 | DOI:10.1016/j.jinorgbio.2023.112434 (Source: Journal of Inorganic Biochemistry)
Source: Journal of Inorganic Biochemistry - November 29, 2023 Category: Biochemistry Authors: Wei Tian Wen Zhong Zengyan Yang Ling Chen Shijie Lin Yanping Li Yuxing Wang Peilin Yang Xing Long Source Type: research
Chemistry meets biology in the coordination dynamics of metalloproteins
This article addresses the plasticity and complexity of metal coordination in proteins when these parameters are considered. It uses three examples of zinc sites with sulfur donor atoms from cysteines in mammalian proteins: alcohol dehydrogenases, metallothioneins, and zinc transporters of the ZnT (SLC30A) family. Coordination dynamics of the metal sites in these proteins has different purposes; in alcohol dehydrogenases for the metal ion to perform its different roles in the catalytic cycle, in metallothioneins for serving as a metal buffer, and in ZnT zinc transporters for sensing metal ions and moving them through the p...
Source: Journal of Inorganic Biochemistry - November 28, 2023 Category: Biochemistry Authors: Wolfgang Maret Source Type: research
Molecular analysis of the human cytoglobin mRNA isoforms
J Inorg Biochem. 2023 Nov 15;251:112422. doi: 10.1016/j.jinorgbio.2023.112422. Online ahead of print.ABSTRACTMultiple functions have been proposed for the ubiquitously expressed vertebrate globin cytoglobin (Cygb), including nitric oxide (NO) metabolism, lipid peroxidation/signalling, superoxide dismutase activity, reactive oxygen/nitrogen species (RONS) scavenging, regulation of blood pressure, antifibrosis, and both tumour suppressor and oncogenic effects. Since alternative splicing can expand the biological roles of a gene, we investigated whether this mechanism contributes to the functional diversity of Cygb. By mining...
Source: Journal of Inorganic Biochemistry - November 28, 2023 Category: Biochemistry Authors: Elena Porto Paraskevi Loula Susanne Strand Thomas Hankeln Source Type: research
Synthesis and photothermal conversion properties of sandwich N-fused porphyrin rhodium- μ-dichloride dimer complexes: π-extended analog of pentamethylcyclopentadienyl dirhodium(III)-μ-dichloride dimer
J Inorg Biochem. 2023 Nov 22;251:112435. doi: 10.1016/j.jinorgbio.2023.112435. Online ahead of print.ABSTRACTAnionic cyclopentadienyl (Cp) and its pentamethyl-substituted derivative (Cp*) serve as crucial ligands for creating stable π-coordinated materials, including catalysts. From a structural perspective, the π-extended analog of Cp, known as an N-fused porphyrin (NFP), is recognized as an intriguing 18π aromatic chromophore, offering near-infrared (NIR) optical properties that can be fine-tuned through metal complexation. When coordinated with rhodium at the central NFP core, it forms a sandwich binuclear rhodium(II...
Source: Journal of Inorganic Biochemistry - November 28, 2023 Category: Biochemistry Authors: Jibin Alex Abraham Hidetoshi Tsuruda Shigeki Mori Masatoshi Ishida Hiroyuki Furuta Source Type: research
Lead to hit ruthenium-cyclopentadienyl anticancer compounds: Cytotoxicity against breast cancer cells, metabolic stability and metabolite profiling
J Inorg Biochem. 2023 Nov 23;251:112436. doi: 10.1016/j.jinorgbio.2023.112436. Online ahead of print.ABSTRACTThe successful choice of hit compounds during drug development programs involves the integration of structure-activity relationship (SAR) studies with pharmacokinetic determinations, including metabolic stability assays and metabolite profiling. A panel of nine ruthenium-cyclopentadienyl (RuCp) compounds with the general formula [Ru(η5-C5H4R)(PPh3)(bipyR')]+ (with R = H, CHO, CH2OH; R' = H, CH3, CH2OH, CH2Biotin) has been tested against hormone-dependent MCF-7 and triple negative MDA-MB-231 breast cancer cells. In ...
Source: Journal of Inorganic Biochemistry - November 28, 2023 Category: Biochemistry Authors: In ês Maximiano Catarina Henriques Ricardo G Teixeira Fernanda Marques Andreia Valente Alexandra M M Antunes Source Type: research
Copper(II) complexes with plumbagin and bipyridines target mitochondria for enhanced chemodynamic cancer therapy
J Inorg Biochem. 2023 Nov 21;251:112432. doi: 10.1016/j.jinorgbio.2023.112432. Online ahead of print.ABSTRACTThe combination of mitochondrial targeting and chemodynamic therapy is a promising anti-cancer strategy. Three mitochondria targeting copper(II) complexes (Cu1-Cu3) with plumbagin and bipyridine ligands for enhanced chemodynamic therapy were synthesized and characterized. Their anti-proliferative activity to HeLa cells was higher than that of cisplatin, and their toxicity to normal cells was low. Cellular uptake and distribution studies indicated that Cu1 and Cu3 were mainly accumulated in mitochondria. The mechanis...
Source: Journal of Inorganic Biochemistry - November 28, 2023 Category: Biochemistry Authors: Hai-Qun Zhang Xing Lu Hong Liang Zhen-Feng Chen Source Type: research
A novel benzothiazole-based mononuclear platinum(II) complex displaying potent antiproliferative activity in HepG-2 cells via mitochondrial-mediated apoptosis
J Inorg Biochem. 2023 Nov 22;251:112437. doi: 10.1016/j.jinorgbio.2023.112437. Online ahead of print.ABSTRACTA novel mononuclear platinum(II) complex, [Pt(L-H)Cl] (1, where L= N-(4-(benzo[d]thiazol-2-yl)phenyl)-2-((2-pyridylmethyl)(2-hydroxyethyl)-amino)acetamide), was obtained by covalently tethering a benzothiazole derivative 2-(4-aminophenyl)benzothiazole to the 2-pyridylmethyl-2-hydroxyethylamine chelating PtII center. In vitro tests indicated that complex 1 displayed excellent antiproliferative activity against the tested cancer cell lines, especially liver cancer HepG-2 and SMMC-7221 cells. Importantly, the complex p...
Source: Journal of Inorganic Biochemistry - November 28, 2023 Category: Biochemistry Authors: Dandan Zhao Hongyan Zhen Jian Xue Zhipeng Tang Xiaofang Han Zhanfen Chen Source Type: research
Chemistry meets biology in the coordination dynamics of metalloproteins
This article addresses the plasticity and complexity of metal coordination in proteins when these parameters are considered. It uses three examples of zinc sites with sulfur donor atoms from cysteines in mammalian proteins: alcohol dehydrogenases, metallothioneins, and zinc transporters of the ZnT (SLC30A) family. Coordination dynamics of the metal sites in these proteins has different purposes; in alcohol dehydrogenases for the metal ion to perform its different roles in the catalytic cycle, in metallothioneins for serving as a metal buffer, and in ZnT zinc transporters for sensing metal ions and moving them through the p...
Source: Journal of Inorganic Biochemistry - November 28, 2023 Category: Biochemistry Authors: Wolfgang Maret Source Type: research
Molecular analysis of the human cytoglobin mRNA isoforms
J Inorg Biochem. 2023 Nov 15;251:112422. doi: 10.1016/j.jinorgbio.2023.112422. Online ahead of print.ABSTRACTMultiple functions have been proposed for the ubiquitously expressed vertebrate globin cytoglobin (Cygb), including nitric oxide (NO) metabolism, lipid peroxidation/signalling, superoxide dismutase activity, reactive oxygen/nitrogen species (RONS) scavenging, regulation of blood pressure, antifibrosis, and both tumour suppressor and oncogenic effects. Since alternative splicing can expand the biological roles of a gene, we investigated whether this mechanism contributes to the functional diversity of Cygb. By mining...
Source: Journal of Inorganic Biochemistry - November 28, 2023 Category: Biochemistry Authors: Elena Porto Paraskevi Loula Susanne Strand Thomas Hankeln Source Type: research
Synthesis and photothermal conversion properties of sandwich N-fused porphyrin rhodium- μ-dichloride dimer complexes: π-extended analog of pentamethylcyclopentadienyl dirhodium(III)-μ-dichloride dimer
J Inorg Biochem. 2023 Nov 22;251:112435. doi: 10.1016/j.jinorgbio.2023.112435. Online ahead of print.ABSTRACTAnionic cyclopentadienyl (Cp) and its pentamethyl-substituted derivative (Cp*) serve as crucial ligands for creating stable π-coordinated materials, including catalysts. From a structural perspective, the π-extended analog of Cp, known as an N-fused porphyrin (NFP), is recognized as an intriguing 18π aromatic chromophore, offering near-infrared (NIR) optical properties that can be fine-tuned through metal complexation. When coordinated with rhodium at the central NFP core, it forms a sandwich binuclear rhodium(II...
Source: Journal of Inorganic Biochemistry - November 28, 2023 Category: Biochemistry Authors: Jibin Alex Abraham Hidetoshi Tsuruda Shigeki Mori Masatoshi Ishida Hiroyuki Furuta Source Type: research
Lead to hit ruthenium-cyclopentadienyl anticancer compounds: Cytotoxicity against breast cancer cells, metabolic stability and metabolite profiling
J Inorg Biochem. 2023 Nov 23;251:112436. doi: 10.1016/j.jinorgbio.2023.112436. Online ahead of print.ABSTRACTThe successful choice of hit compounds during drug development programs involves the integration of structure-activity relationship (SAR) studies with pharmacokinetic determinations, including metabolic stability assays and metabolite profiling. A panel of nine ruthenium-cyclopentadienyl (RuCp) compounds with the general formula [Ru(η5-C5H4R)(PPh3)(bipyR')]+ (with R = H, CHO, CH2OH; R' = H, CH3, CH2OH, CH2Biotin) has been tested against hormone-dependent MCF-7 and triple negative MDA-MB-231 breast cancer cells. In ...
Source: Journal of Inorganic Biochemistry - November 28, 2023 Category: Biochemistry Authors: In ês Maximiano Catarina Henriques Ricardo G Teixeira Fernanda Marques Andreia Valente Alexandra M M Antunes Source Type: research
Copper(II) complexes with plumbagin and bipyridines target mitochondria for enhanced chemodynamic cancer therapy
J Inorg Biochem. 2023 Nov 21;251:112432. doi: 10.1016/j.jinorgbio.2023.112432. Online ahead of print.ABSTRACTThe combination of mitochondrial targeting and chemodynamic therapy is a promising anti-cancer strategy. Three mitochondria targeting copper(II) complexes (Cu1-Cu3) with plumbagin and bipyridine ligands for enhanced chemodynamic therapy were synthesized and characterized. Their anti-proliferative activity to HeLa cells was higher than that of cisplatin, and their toxicity to normal cells was low. Cellular uptake and distribution studies indicated that Cu1 and Cu3 were mainly accumulated in mitochondria. The mechanis...
Source: Journal of Inorganic Biochemistry - November 28, 2023 Category: Biochemistry Authors: Hai-Qun Zhang Xing Lu Hong Liang Zhen-Feng Chen Source Type: research
A novel benzothiazole-based mononuclear platinum(II) complex displaying potent antiproliferative activity in HepG-2 cells via mitochondrial-mediated apoptosis
J Inorg Biochem. 2023 Nov 22;251:112437. doi: 10.1016/j.jinorgbio.2023.112437. Online ahead of print.ABSTRACTA novel mononuclear platinum(II) complex, [Pt(L-H)Cl] (1, where L= N-(4-(benzo[d]thiazol-2-yl)phenyl)-2-((2-pyridylmethyl)(2-hydroxyethyl)-amino)acetamide), was obtained by covalently tethering a benzothiazole derivative 2-(4-aminophenyl)benzothiazole to the 2-pyridylmethyl-2-hydroxyethylamine chelating PtII center. In vitro tests indicated that complex 1 displayed excellent antiproliferative activity against the tested cancer cell lines, especially liver cancer HepG-2 and SMMC-7221 cells. Importantly, the complex p...
Source: Journal of Inorganic Biochemistry - November 28, 2023 Category: Biochemistry Authors: Dandan Zhao Hongyan Zhen Jian Xue Zhipeng Tang Xiaofang Han Zhanfen Chen Source Type: research
