Synthesis, characterization, and cytotoxic effects of new copper complexes using Schiff-base derivatives from natural sources
J Inorg Biochem. 2023 Oct 14;250:112401. doi: 10.1016/j.jinorgbio.2023.112401. Online ahead of print.ABSTRACTCopper(II) complexes are interesting for cancer treatment due to their unique properties, including their redox potential, possible coordination structures with different ligands, the most diverse geometries, and different biomolecule reactivity. The present work synthesized new copper(II) complexes with Schiff-base (imine) type ligands using natural aldehydes such as cinnamaldehyde, vanillin, or ethyl vanillin. The ligands were obtained through the reaction of these aldehydes with the amines 1,3-diaminopropane, 2,2...
Source: Journal of Inorganic Biochemistry - October 21, 2023 Category: Biochemistry Authors: Rafael N Gomes Matheus L Silva Kaio S Gomes Jo ão H G Lago Giselle Cerchiaro Source Type: research
"Antibacterial properties of nine indium(III) complexes of substituted pyrazoles/pyrazolate and the structural and solution characterization of the mer- and trans ‑indium(III) complexes of 4-Me-pzH"
J Inorg Biochem. 2023 Oct 14;250:112402. doi: 10.1016/j.jinorgbio.2023.112402. Online ahead of print.ABSTRACTTwo indium(III) complexes of formula mer-[InIIICl3(4-Me-pzH)3] and trans-[InIIICl2(4-Me-pzH)4]Cl·(4-Me-pzH)2·(H2O) were isolated from the same reaction mixture and crystallographically characterized. The two complexes exist in dynamic equilibrium and their dynamic behavior was probed by variable temperature 1H NMR spectroscopy in the 202 to 296 K range. Powder X-ray diffraction of the batch confirmed existence of both complexes in a 1:2 ratio. Antibacterial properties of both new complexes, in addition to seven ot...
Source: Journal of Inorganic Biochemistry - October 19, 2023 Category: Biochemistry Authors: Susana Herrera Masafumi Yoshinaga Raphael G Raptis Source Type: research
"Antibacterial properties of nine indium(III) complexes of substituted pyrazoles/pyrazolate and the structural and solution characterization of the mer- and trans ‑indium(III) complexes of 4-Me-pzH"
J Inorg Biochem. 2023 Oct 14;250:112402. doi: 10.1016/j.jinorgbio.2023.112402. Online ahead of print.ABSTRACTTwo indium(III) complexes of formula mer-[InIIICl3(4-Me-pzH)3] and trans-[InIIICl2(4-Me-pzH)4]Cl·(4-Me-pzH)2·(H2O) were isolated from the same reaction mixture and crystallographically characterized. The two complexes exist in dynamic equilibrium and their dynamic behavior was probed by variable temperature 1H NMR spectroscopy in the 202 to 296 K range. Powder X-ray diffraction of the batch confirmed existence of both complexes in a 1:2 ratio. Antibacterial properties of both new complexes, in addition to seven ot...
Source: Journal of Inorganic Biochemistry - October 19, 2023 Category: Biochemistry Authors: Susana Herrera Masafumi Yoshinaga Raphael G Raptis Source Type: research
Removal and degradation of sodium diclofenac via radical-based mechanisms using S. sclerotiorum laccase
J Inorg Biochem. 2023 Oct 11;249:112400. doi: 10.1016/j.jinorgbio.2023.112400. Online ahead of print.ABSTRACTThe recently isolated Sclerotinia sclerotiorum laccase was used for the degradation of sodium diclofenac, a nonsteroidal anti-inflammatory drug widely found in the aquatic environment. The Michaelis-Menten parameters, half-life of diclofenac at different pH values in presence of this enzyme and potential inhibitors were evaluated. Diclofenac-based radicals formed in presence of laccase were spin-trapped and detected using EPR spectroscopy. Almost complete diclofenac degradation (> 96%) occurred after a 30-h treat...
Source: Journal of Inorganic Biochemistry - October 16, 2023 Category: Biochemistry Authors: Cristina Coman Niculina H ădade Szil árd Pesek Radu Silaghi-Dumitrescu Augustin C Mo ț Source Type: research
Mitochondria-targeted cyclometalated iridium (III) complexes: Dual induction of A549 cells apoptosis and autophagy
In this study, we synthesized 4 cyclometalated iridium complexes using N-(1,10-phenanthrolin-5-yl)picolinamide (PPA) as the main ligand, denoted as [Ir(ppy)2PPA]PF6 (ppy = 2-phenylpyridine, Ir1), [Ir(bzq)2PPA]PF6 (bzq = benzo[h]quinoline, Ir2), [Ir(dfppy)2PPA]PF6 (dfppy = 2-(3,5-difluorophenyl)pyridine, Ir3), and [Ir(thpy)2PPA]PF6 (thpy = 2-(thiophene-2-yl)pyridine, Ir4). Compared to cisplatin and oxaliplatin, all four complexes exhibited significant anti-tumor activity. Among them, Ir2 demonstrated higher cytotoxicity against A549 cells, with an IC50 value of 1.6 ± 0.2 μM. The experimental results indicated that Ir2 pri...
Source: Journal of Inorganic Biochemistry - October 16, 2023 Category: Biochemistry Authors: Lanmei Chen Hong Tang Weigang Chen Jie Wang Shenting Zhang Jie Gao Yu Chen Xufeng Zhu Zunnan Huang Jincan Chen Source Type: research
Removal and degradation of sodium diclofenac via radical-based mechanisms using S. sclerotiorum laccase
J Inorg Biochem. 2023 Oct 11;249:112400. doi: 10.1016/j.jinorgbio.2023.112400. Online ahead of print.ABSTRACTThe recently isolated Sclerotinia sclerotiorum laccase was used for the degradation of sodium diclofenac, a nonsteroidal anti-inflammatory drug widely found in the aquatic environment. The Michaelis-Menten parameters, half-life of diclofenac at different pH values in presence of this enzyme and potential inhibitors were evaluated. Diclofenac-based radicals formed in presence of laccase were spin-trapped and detected using EPR spectroscopy. Almost complete diclofenac degradation (> 96%) occurred after a 30-h treat...
Source: Journal of Inorganic Biochemistry - October 16, 2023 Category: Biochemistry Authors: Cristina Coman Niculina H ădade Szil árd Pesek Radu Silaghi-Dumitrescu Augustin C Mo ț Source Type: research
Mitochondria-targeted cyclometalated iridium (III) complexes: Dual induction of A549 cells apoptosis and autophagy
In this study, we synthesized 4 cyclometalated iridium complexes using N-(1,10-phenanthrolin-5-yl)picolinamide (PPA) as the main ligand, denoted as [Ir(ppy)2PPA]PF6 (ppy = 2-phenylpyridine, Ir1), [Ir(bzq)2PPA]PF6 (bzq = benzo[h]quinoline, Ir2), [Ir(dfppy)2PPA]PF6 (dfppy = 2-(3,5-difluorophenyl)pyridine, Ir3), and [Ir(thpy)2PPA]PF6 (thpy = 2-(thiophene-2-yl)pyridine, Ir4). Compared to cisplatin and oxaliplatin, all four complexes exhibited significant anti-tumor activity. Among them, Ir2 demonstrated higher cytotoxicity against A549 cells, with an IC50 value of 1.6 ± 0.2 μM. The experimental results indicated that Ir2 pri...
Source: Journal of Inorganic Biochemistry - October 16, 2023 Category: Biochemistry Authors: Lanmei Chen Hong Tang Weigang Chen Jie Wang Shenting Zhang Jie Gao Yu Chen Xufeng Zhu Zunnan Huang Jincan Chen Source Type: research
Removal and degradation of sodium diclofenac via radical-based mechanisms using S. sclerotiorum laccase
J Inorg Biochem. 2023 Oct 11;249:112400. doi: 10.1016/j.jinorgbio.2023.112400. Online ahead of print.ABSTRACTThe recently isolated Sclerotinia sclerotiorum laccase was used for the degradation of sodium diclofenac, a nonsteroidal anti-inflammatory drug widely found in the aquatic environment. The Michaelis-Menten parameters, half-life of diclofenac at different pH values in presence of this enzyme and potential inhibitors were evaluated. Diclofenac-based radicals formed in presence of laccase were spin-trapped and detected using EPR spectroscopy. Almost complete diclofenac degradation (> 96%) occurred after a 30-h treat...
Source: Journal of Inorganic Biochemistry - October 16, 2023 Category: Biochemistry Authors: Cristina Coman Niculina H ădade Szil árd Pesek Radu Silaghi-Dumitrescu Augustin C Mo ț Source Type: research
Mitochondria-targeted cyclometalated iridium (III) complexes: Dual induction of A549 cells apoptosis and autophagy
In this study, we synthesized 4 cyclometalated iridium complexes using N-(1,10-phenanthrolin-5-yl)picolinamide (PPA) as the main ligand, denoted as [Ir(ppy)2PPA]PF6 (ppy = 2-phenylpyridine, Ir1), [Ir(bzq)2PPA]PF6 (bzq = benzo[h]quinoline, Ir2), [Ir(dfppy)2PPA]PF6 (dfppy = 2-(3,5-difluorophenyl)pyridine, Ir3), and [Ir(thpy)2PPA]PF6 (thpy = 2-(thiophene-2-yl)pyridine, Ir4). Compared to cisplatin and oxaliplatin, all four complexes exhibited significant anti-tumor activity. Among them, Ir2 demonstrated higher cytotoxicity against A549 cells, with an IC50 value of 1.6 ± 0.2 μM. The experimental results indicated that Ir2 pri...
Source: Journal of Inorganic Biochemistry - October 16, 2023 Category: Biochemistry Authors: Lanmei Chen Hong Tang Weigang Chen Jie Wang Shenting Zhang Jie Gao Yu Chen Xufeng Zhu Zunnan Huang Jincan Chen Source Type: research
Interactions of ruthenium(II) polypyridyl complexes with human telomeric DNA
J Inorg Biochem. 2023 Sep 26;249:112388. doi: 10.1016/j.jinorgbio.2023.112388. Online ahead of print.ABSTRACTEight [Ru(bpy)2L]2+ and three [Ru(phen)2L]2+complexes (where bpy = 2,2'-bipyridine and phen = 1,10-phenanthroline are ancillary ligands, and L = a polypyridyl experimental ligand) were investigated for their G-quadruplex binding abilities. Fluorescence resonance energy transfer melting assays were used to screen these complexes for their ability to selectively stabilize human telomeric DNA variant, Tel22. The best G-quadruplex stabilizers were further characterized for their binding properties (binding constant and ...
Source: Journal of Inorganic Biochemistry - October 14, 2023 Category: Biochemistry Authors: Vienna T Tran Joshua Turek-Herman Michelle Ferreira Kailey N Martin Dana Beseiso Benjamin R Williams Frederic Rosu Val érie Gabelica Sharon J Nieter Burgmayer Liliya A Yatsunyk Source Type: research
Characterisation of the heme aqua-ligand coordination environment in an engineered peroxygenase cytochrome P450 variant
J Inorg Biochem. 2023 Oct 4;249:112391. doi: 10.1016/j.jinorgbio.2023.112391. Online ahead of print.ABSTRACTThe cytochrome P450 enzymes (CYPs) are heme-thiolate monooxygenases that catalyse the insertion of an oxygen atom into the C-H bonds of organic molecules. In most CYPs, the activation of dioxygen by the heme is aided by an acid-alcohol pair of residues located in the I-helix of the enzyme. Mutation of the threonine residue of this acid-alcohol pair of CYP199A4, from the bacterium Rhodospeudomonas palustris HaA2, to a glutamate residue induces peroxygenase activity. In the X-ray crystal structures of this variant an i...
Source: Journal of Inorganic Biochemistry - October 14, 2023 Category: Biochemistry Authors: Matthew N Podgorski Joel H Z Lee Joshua S Harbort Giang T H Nguyen Daniel Z Doherty William A Donald Jeffrey R Harmer John B Bruning Stephen G Bell Source Type: research
Jonathan B. Wittenberg (1923-2023)
J Inorg Biochem. 2023 Oct 12:112396. doi: 10.1016/j.jinorgbio.2023.112396. Online ahead of print.NO ABSTRACTPMID:37838607 | DOI:10.1016/j.jinorgbio.2023.112396 (Source: Journal of Inorganic Biochemistry)
Source: Journal of Inorganic Biochemistry - October 14, 2023 Category: Biochemistry Authors: Paolo Ascenzi Martino Bolognesi Michel Guertin Luc Moens Source Type: research
Interactions of ruthenium(II) polypyridyl complexes with human telomeric DNA
J Inorg Biochem. 2023 Sep 26;249:112388. doi: 10.1016/j.jinorgbio.2023.112388. Online ahead of print.ABSTRACTEight [Ru(bpy)2L]2+ and three [Ru(phen)2L]2+complexes (where bpy = 2,2'-bipyridine and phen = 1,10-phenanthroline are ancillary ligands, and L = a polypyridyl experimental ligand) were investigated for their G-quadruplex binding abilities. Fluorescence resonance energy transfer melting assays were used to screen these complexes for their ability to selectively stabilize human telomeric DNA variant, Tel22. The best G-quadruplex stabilizers were further characterized for their binding properties (binding constant and ...
Source: Journal of Inorganic Biochemistry - October 14, 2023 Category: Biochemistry Authors: Vienna T Tran Joshua Turek-Herman Michelle Ferreira Kailey N Martin Dana Beseiso Benjamin R Williams Frederic Rosu Val érie Gabelica Sharon J Nieter Burgmayer Liliya A Yatsunyk Source Type: research
Characterisation of the heme aqua-ligand coordination environment in an engineered peroxygenase cytochrome P450 variant
J Inorg Biochem. 2023 Oct 4;249:112391. doi: 10.1016/j.jinorgbio.2023.112391. Online ahead of print.ABSTRACTThe cytochrome P450 enzymes (CYPs) are heme-thiolate monooxygenases that catalyse the insertion of an oxygen atom into the C-H bonds of organic molecules. In most CYPs, the activation of dioxygen by the heme is aided by an acid-alcohol pair of residues located in the I-helix of the enzyme. Mutation of the threonine residue of this acid-alcohol pair of CYP199A4, from the bacterium Rhodospeudomonas palustris HaA2, to a glutamate residue induces peroxygenase activity. In the X-ray crystal structures of this variant an i...
Source: Journal of Inorganic Biochemistry - October 14, 2023 Category: Biochemistry Authors: Matthew N Podgorski Joel H Z Lee Joshua S Harbort Giang T H Nguyen Daniel Z Doherty William A Donald Jeffrey R Harmer John B Bruning Stephen G Bell Source Type: research
Jonathan B. Wittenberg (1923-2023)
J Inorg Biochem. 2023 Oct 12:112396. doi: 10.1016/j.jinorgbio.2023.112396. Online ahead of print.NO ABSTRACTPMID:37838607 | DOI:10.1016/j.jinorgbio.2023.112396 (Source: Journal of Inorganic Biochemistry)
Source: Journal of Inorganic Biochemistry - October 14, 2023 Category: Biochemistry Authors: Paolo Ascenzi Martino Bolognesi Michel Guertin Luc Moens Source Type: research
