Cytotoxic auranofin analogues bearing phosphine, arsine and stibine ligands: A study on the possible role of the ligand on the biological activity
J Inorg Biochem. 2023 Dec 3;251:112452. doi: 10.1016/j.jinorgbio.2023.112452. Online ahead of print.ABSTRACTThree gold(I) linear compounds, sharing the general formula [AuI(LPh3)], have been synthesized and characterized. The nature of the ligand has been modified by moving down among some of the elements of group 15, i.e. phosphorus, arsenic and antimony. The structures of derived compounds have been solved through XRD and the reactivity behaviour towards selected biomolecules has been investigated through a multi-technique approach involving NMR, high-resolution mass spectrometry and IR. Moreover, the biological activity...
Source: Journal of Inorganic Biochemistry - December 9, 2023 Category: Biochemistry Authors: Ester Giorgi Michele Mannelli Tania Gamberi Maria Durante Chiara Gabbiani Damiano Cirri Alessandro Pratesi Source Type: research
Cytotoxic auranofin analogues bearing phosphine, arsine and stibine ligands: A study on the possible role of the ligand on the biological activity
J Inorg Biochem. 2023 Dec 3;251:112452. doi: 10.1016/j.jinorgbio.2023.112452. Online ahead of print.ABSTRACTThree gold(I) linear compounds, sharing the general formula [AuI(LPh3)], have been synthesized and characterized. The nature of the ligand has been modified by moving down among some of the elements of group 15, i.e. phosphorus, arsenic and antimony. The structures of derived compounds have been solved through XRD and the reactivity behaviour towards selected biomolecules has been investigated through a multi-technique approach involving NMR, high-resolution mass spectrometry and IR. Moreover, the biological activity...
Source: Journal of Inorganic Biochemistry - December 9, 2023 Category: Biochemistry Authors: Ester Giorgi Michele Mannelli Tania Gamberi Maria Durante Chiara Gabbiani Damiano Cirri Alessandro Pratesi Source Type: research
Cytotoxic auranofin analogues bearing phosphine, arsine and stibine ligands: A study on the possible role of the ligand on the biological activity
J Inorg Biochem. 2023 Dec 3;251:112452. doi: 10.1016/j.jinorgbio.2023.112452. Online ahead of print.ABSTRACTThree gold(I) linear compounds, sharing the general formula [AuI(LPh3)], have been synthesized and characterized. The nature of the ligand has been modified by moving down among some of the elements of group 15, i.e. phosphorus, arsenic and antimony. The structures of derived compounds have been solved through XRD and the reactivity behaviour towards selected biomolecules has been investigated through a multi-technique approach involving NMR, high-resolution mass spectrometry and IR. Moreover, the biological activity...
Source: Journal of Inorganic Biochemistry - December 9, 2023 Category: Biochemistry Authors: Ester Giorgi Michele Mannelli Tania Gamberi Maria Durante Chiara Gabbiani Damiano Cirri Alessandro Pratesi Source Type: research
Phenanthroline and Schiff Base associated Cu(II)-coordinated compounds containing N, O as donor atoms for potent anticancer activity
J Inorg Biochem. 2023 Dec 1;251:112440. doi: 10.1016/j.jinorgbio.2023.112440. Online ahead of print.ABSTRACTAs an inherent metal ion, copper has been the subject of investigation for developing a novel antitumoral compound that exhibits fewer adverse effects. Copper serves as a cofactor in multiple enzymes, generates reactive oxygen species (ROS), facilitates tumour evolution, metastasis and angiogenesis and has been detected at elevated concentrations in the serum and tissues of various human cancer types. In the given setting, utilising two methodologies in developing novel Copper-based pharmaceuticals for anti-cancer ap...
Source: Journal of Inorganic Biochemistry - December 8, 2023 Category: Biochemistry Authors: None Richa Vinod Kumar Ramesh Kataria Source Type: research
Phenanthroline and Schiff Base associated Cu(II)-coordinated compounds containing N, O as donor atoms for potent anticancer activity
J Inorg Biochem. 2023 Dec 1;251:112440. doi: 10.1016/j.jinorgbio.2023.112440. Online ahead of print.ABSTRACTAs an inherent metal ion, copper has been the subject of investigation for developing a novel antitumoral compound that exhibits fewer adverse effects. Copper serves as a cofactor in multiple enzymes, generates reactive oxygen species (ROS), facilitates tumour evolution, metastasis and angiogenesis and has been detected at elevated concentrations in the serum and tissues of various human cancer types. In the given setting, utilising two methodologies in developing novel Copper-based pharmaceuticals for anti-cancer ap...
Source: Journal of Inorganic Biochemistry - December 8, 2023 Category: Biochemistry Authors: None Richa Vinod Kumar Ramesh Kataria Source Type: research
Altering relative metal-binding affinities in multifunctional Metallochaperones for mutant p53 reactivation
J Inorg Biochem. 2023 Nov 22;251:112433. doi: 10.1016/j.jinorgbio.2023.112433. Online ahead of print.ABSTRACTThe p53 protein plays a major role in cancer prevention, and over 50% of cancer diagnoses can be attributed to p53 malfunction. p53 incorporates a structural Zn site that is required for proper protein folding and function, and in many cases point mutations can result in loss of the Zn2+ ion, destabilization of the tertiary structure, and eventual amyloid aggregation. Herein, we report a series of compounds designed to act as small molecule stabilizers of mutant p53, and feature Zn-binding fragments to chaperone Zn2...
Source: Journal of Inorganic Biochemistry - December 3, 2023 Category: Biochemistry Authors: Kalvin Kwan Omar Castro-Sandoval Benjamin Ma Diego Martelino Ashkan Saffari Xi Lan Liu Christophe Orvain Georg Mellitzer Christian Gaiddon Tim Storr Source Type: research
Altering relative metal-binding affinities in multifunctional Metallochaperones for mutant p53 reactivation
J Inorg Biochem. 2023 Nov 22;251:112433. doi: 10.1016/j.jinorgbio.2023.112433. Online ahead of print.ABSTRACTThe p53 protein plays a major role in cancer prevention, and over 50% of cancer diagnoses can be attributed to p53 malfunction. p53 incorporates a structural Zn site that is required for proper protein folding and function, and in many cases point mutations can result in loss of the Zn2+ ion, destabilization of the tertiary structure, and eventual amyloid aggregation. Herein, we report a series of compounds designed to act as small molecule stabilizers of mutant p53, and feature Zn-binding fragments to chaperone Zn2...
Source: Journal of Inorganic Biochemistry - December 3, 2023 Category: Biochemistry Authors: Kalvin Kwan Omar Castro-Sandoval Benjamin Ma Diego Martelino Ashkan Saffari Xi Lan Liu Christophe Orvain Georg Mellitzer Christian Gaiddon Tim Storr Source Type: research
Altering relative metal-binding affinities in multifunctional Metallochaperones for mutant p53 reactivation
J Inorg Biochem. 2023 Nov 22;251:112433. doi: 10.1016/j.jinorgbio.2023.112433. Online ahead of print.ABSTRACTThe p53 protein plays a major role in cancer prevention, and over 50% of cancer diagnoses can be attributed to p53 malfunction. p53 incorporates a structural Zn site that is required for proper protein folding and function, and in many cases point mutations can result in loss of the Zn2+ ion, destabilization of the tertiary structure, and eventual amyloid aggregation. Herein, we report a series of compounds designed to act as small molecule stabilizers of mutant p53, and feature Zn-binding fragments to chaperone Zn2...
Source: Journal of Inorganic Biochemistry - December 3, 2023 Category: Biochemistry Authors: Kalvin Kwan Omar Castro-Sandoval Benjamin Ma Diego Martelino Ashkan Saffari Xi Lan Liu Christophe Orvain Georg Mellitzer Christian Gaiddon Tim Storr Source Type: research
Altering relative metal-binding affinities in multifunctional Metallochaperones for mutant p53 reactivation
J Inorg Biochem. 2023 Nov 22;251:112433. doi: 10.1016/j.jinorgbio.2023.112433. Online ahead of print.ABSTRACTThe p53 protein plays a major role in cancer prevention, and over 50% of cancer diagnoses can be attributed to p53 malfunction. p53 incorporates a structural Zn site that is required for proper protein folding and function, and in many cases point mutations can result in loss of the Zn2+ ion, destabilization of the tertiary structure, and eventual amyloid aggregation. Herein, we report a series of compounds designed to act as small molecule stabilizers of mutant p53, and feature Zn-binding fragments to chaperone Zn2...
Source: Journal of Inorganic Biochemistry - December 3, 2023 Category: Biochemistry Authors: Kalvin Kwan Omar Castro-Sandoval Benjamin Ma Diego Martelino Ashkan Saffari Xi Lan Liu Christophe Orvain Georg Mellitzer Christian Gaiddon Tim Storr Source Type: research
Altering relative metal-binding affinities in multifunctional Metallochaperones for mutant p53 reactivation
J Inorg Biochem. 2023 Nov 22;251:112433. doi: 10.1016/j.jinorgbio.2023.112433. Online ahead of print.ABSTRACTThe p53 protein plays a major role in cancer prevention, and over 50% of cancer diagnoses can be attributed to p53 malfunction. p53 incorporates a structural Zn site that is required for proper protein folding and function, and in many cases point mutations can result in loss of the Zn2+ ion, destabilization of the tertiary structure, and eventual amyloid aggregation. Herein, we report a series of compounds designed to act as small molecule stabilizers of mutant p53, and feature Zn-binding fragments to chaperone Zn2...
Source: Journal of Inorganic Biochemistry - December 3, 2023 Category: Biochemistry Authors: Kalvin Kwan Omar Castro-Sandoval Benjamin Ma Diego Martelino Ashkan Saffari Xi Lan Liu Christophe Orvain Georg Mellitzer Christian Gaiddon Tim Storr Source Type: research
Forming a chromium-based interstrand DNA crosslink: Implications for carcinogenicity
J Inorg Biochem. 2023 Nov 25;251:112439. doi: 10.1016/j.jinorgbio.2023.112439. Online ahead of print.ABSTRACTThe reduction of the carcinogen chromate has been proposed to lead to three Cr(III)-containing DNA lesions: binary adducts (Cr(III) and DNA), interstrand crosslinks, and ternary adducts (Cr(III) linking DNA to a small molecule or protein). Although the structures of binary adducts have recently been elucidated, the structures of interstrand crosslinks and ternary adducts are not known. Analysis of Cr(III) binding to an oligonucleotide duplex containing a 5'-CG site allows elucidation of the structure of an oxide- or...
Source: Journal of Inorganic Biochemistry - December 1, 2023 Category: Biochemistry Authors: Silas Brown Sydney Marchi C Sumner Thomas Ashlyn R Hale Molly Lockart Michael K Bowman George Christou Stephen A Woski John B Vincent Source Type: research
Forming a chromium-based interstrand DNA crosslink: Implications for carcinogenicity
J Inorg Biochem. 2023 Nov 25;251:112439. doi: 10.1016/j.jinorgbio.2023.112439. Online ahead of print.ABSTRACTThe reduction of the carcinogen chromate has been proposed to lead to three Cr(III)-containing DNA lesions: binary adducts (Cr(III) and DNA), interstrand crosslinks, and ternary adducts (Cr(III) linking DNA to a small molecule or protein). Although the structures of binary adducts have recently been elucidated, the structures of interstrand crosslinks and ternary adducts are not known. Analysis of Cr(III) binding to an oligonucleotide duplex containing a 5'-CG site allows elucidation of the structure of an oxide- or...
Source: Journal of Inorganic Biochemistry - December 1, 2023 Category: Biochemistry Authors: Silas Brown Sydney Marchi C Sumner Thomas Ashlyn R Hale Molly Lockart Michael K Bowman George Christou Stephen A Woski John B Vincent Source Type: research
Gold(III) complexes with thiosemicarbazone ligands: insights into their cytotoxic effects on lung cancer cells
In this study, three gold(III) complexes derived from thiosemicarbazone ligands have been synthesized, fully characterized, including their X-ray crystal structures. We conducted initial mode-of-action studies on DNA and BSA, followed by a comprehensive investigation into the cytotoxic effects of these novel gold(III) complexes on lung cancer cells (A549, H2052, and H28). The results demonstrated a concentration-dependent cytotoxic response, with H28 cells exhibiting the highest sensitivity to the treatment. Furthermore, the analysis of the cell cycle revealed that these compounds induce cell cycle arrest and promote apopt...
Source: Journal of Inorganic Biochemistry - November 29, 2023 Category: Biochemistry Authors: Mirco Scaccaglia Silvana Pinelli Luca Manini Benedetta Ghezzi Maria Nicastro Julian Heinrich Nora Kulak Paola Mozzoni Giorgio Pelosi Franco Bisceglie Source Type: research
Synthesis, characterization and discovery of multiple anticancer mechanisms of dibutyltin complexes based on salen-like ligands
This study reveals new mechanisms of organotin complexes and provides new insights into the development of organotin metal complexes as anticancer drugs in the future, and compounds with multiple anticancer mechanisms may be a new strategy for delaying or overcoming drug resistance to chemotherapy and target therapy.PMID:38029537 | DOI:10.1016/j.jinorgbio.2023.112434 (Source: Journal of Inorganic Biochemistry)
Source: Journal of Inorganic Biochemistry - November 29, 2023 Category: Biochemistry Authors: Wei Tian Wen Zhong Zengyan Yang Ling Chen Shijie Lin Yanping Li Yuxing Wang Peilin Yang Xing Long Source Type: research
Gold(III) complexes with thiosemicarbazone ligands: insights into their cytotoxic effects on lung cancer cells
In this study, three gold(III) complexes derived from thiosemicarbazone ligands have been synthesized, fully characterized, including their X-ray crystal structures. We conducted initial mode-of-action studies on DNA and BSA, followed by a comprehensive investigation into the cytotoxic effects of these novel gold(III) complexes on lung cancer cells (A549, H2052, and H28). The results demonstrated a concentration-dependent cytotoxic response, with H28 cells exhibiting the highest sensitivity to the treatment. Furthermore, the analysis of the cell cycle revealed that these compounds induce cell cycle arrest and promote apopt...
Source: Journal of Inorganic Biochemistry - November 29, 2023 Category: Biochemistry Authors: Mirco Scaccaglia Silvana Pinelli Luca Manini Benedetta Ghezzi Maria Nicastro Julian Heinrich Nora Kulak Paola Mozzoni Giorgio Pelosi Franco Bisceglie Source Type: research
