Nitrobindin versus myoglobin: A comparative structural and functional study
J Inorg Biochem. 2023 Oct 1:112387. doi: 10.1016/j.jinorgbio.2023.112387. Online ahead of print.ABSTRACTMost hemoproteins display an all-α-helical fold, showing the classical three on three (3/3) globin structural arrangement characterized by seven or eight α-helical segments that form a sandwich around the heme. Over the last decade, a completely distinct class of heme-proteins called nitrobindins (Nbs), which display an all-β-barrel fold, has been identified and characterized from both structural and functional perspectives. Nbs are ten-stranded anti-parallel all-β-barrel heme-proteins found across the evolutionary l...
Source: Journal of Inorganic Biochemistry - November 1, 2023 Category: Biochemistry Authors: Giovanna De Simone Alessandra di Masi Andrea Pasquadibisceglie Andrea Coletta Federico Sebastiani Giulietta Smulevich Massimo Coletta Paolo Ascenzi Source Type: research
Novel diphenyltin(IV) complexes with carboxylato N-functionalized 2-quinolone ligands: Synthesis, characterization and in vitro anticancer studies
J Inorg Biochem. 2023 Oct 16;250:112399. doi: 10.1016/j.jinorgbio.2023.112399. Online ahead of print.ABSTRACTThree new diphenyltin(IV) complexes, bis(3-(4-methyl-2-oxoquinolinyl-1(2H)-yl)propanoato)diphenyltin(IV) (1), bis(2-(4-methyl-2-oxoquinolin-1(2H)-yl)ethanoato)diphenyltin(IV) (2), and bis(2-(4-hydroxy-2-oxoquinolin-1(2H)-yl)ethanoato)diphenyltin(IV) (3), were synthesized and characterized by elemental microanalysis, FT-IR spectroscopy, and multinuclear (1H, 13C and 119Sn) NMR spectroscopy. Crystal structure of ligand precursor, 2-(4-methyl-2-oxoquinolinyl-1-(2H)-yl)acetic acid (HL2), has been determined by X-ray dif...
Source: Journal of Inorganic Biochemistry - October 27, 2023 Category: Biochemistry Authors: Marijana P Kasalovi ć Sanja Jela ča Danijela Maksimovi ć-Ivanić Jelena La đarević Lidija Radovanovi ć Bojan Bo žić Sanja Mijatovi ć Neboj ša Đ Pantelić Goran N Kalu đerović Source Type: research
Novel diphenyltin(IV) complexes with carboxylato N-functionalized 2-quinolone ligands: Synthesis, characterization and in vitro anticancer studies
J Inorg Biochem. 2023 Oct 16;250:112399. doi: 10.1016/j.jinorgbio.2023.112399. Online ahead of print.ABSTRACTThree new diphenyltin(IV) complexes, bis(3-(4-methyl-2-oxoquinolinyl-1(2H)-yl)propanoato)diphenyltin(IV) (1), bis(2-(4-methyl-2-oxoquinolin-1(2H)-yl)ethanoato)diphenyltin(IV) (2), and bis(2-(4-hydroxy-2-oxoquinolin-1(2H)-yl)ethanoato)diphenyltin(IV) (3), were synthesized and characterized by elemental microanalysis, FT-IR spectroscopy, and multinuclear (1H, 13C and 119Sn) NMR spectroscopy. Crystal structure of ligand precursor, 2-(4-methyl-2-oxoquinolinyl-1-(2H)-yl)acetic acid (HL2), has been determined by X-ray dif...
Source: Journal of Inorganic Biochemistry - October 27, 2023 Category: Biochemistry Authors: Marijana P Kasalovi ć Sanja Jela ča Danijela Maksimovi ć-Ivanić Jelena La đarević Lidija Radovanovi ć Bojan Bo žić Sanja Mijatovi ć Neboj ša Đ Pantelić Goran N Kalu đerović Source Type: research
Novel diphenyltin(IV) complexes with carboxylato N-functionalized 2-quinolone ligands: Synthesis, characterization and in vitro anticancer studies
J Inorg Biochem. 2023 Oct 16;250:112399. doi: 10.1016/j.jinorgbio.2023.112399. Online ahead of print.ABSTRACTThree new diphenyltin(IV) complexes, bis(3-(4-methyl-2-oxoquinolinyl-1(2H)-yl)propanoato)diphenyltin(IV) (1), bis(2-(4-methyl-2-oxoquinolin-1(2H)-yl)ethanoato)diphenyltin(IV) (2), and bis(2-(4-hydroxy-2-oxoquinolin-1(2H)-yl)ethanoato)diphenyltin(IV) (3), were synthesized and characterized by elemental microanalysis, FT-IR spectroscopy, and multinuclear (1H, 13C and 119Sn) NMR spectroscopy. Crystal structure of ligand precursor, 2-(4-methyl-2-oxoquinolinyl-1-(2H)-yl)acetic acid (HL2), has been determined by X-ray dif...
Source: Journal of Inorganic Biochemistry - October 27, 2023 Category: Biochemistry Authors: Marijana P Kasalovi ć Sanja Jela ča Danijela Maksimovi ć-Ivanić Jelena La đarević Lidija Radovanovi ć Bojan Bo žić Sanja Mijatovi ć Neboj ša Đ Pantelić Goran N Kalu đerović Source Type: research
Novel diphenyltin(IV) complexes with carboxylato N-functionalized 2-quinolone ligands: Synthesis, characterization and in vitro anticancer studies
J Inorg Biochem. 2023 Oct 16;250:112399. doi: 10.1016/j.jinorgbio.2023.112399. Online ahead of print.ABSTRACTThree new diphenyltin(IV) complexes, bis(3-(4-methyl-2-oxoquinolinyl-1(2H)-yl)propanoato)diphenyltin(IV) (1), bis(2-(4-methyl-2-oxoquinolin-1(2H)-yl)ethanoato)diphenyltin(IV) (2), and bis(2-(4-hydroxy-2-oxoquinolin-1(2H)-yl)ethanoato)diphenyltin(IV) (3), were synthesized and characterized by elemental microanalysis, FT-IR spectroscopy, and multinuclear (1H, 13C and 119Sn) NMR spectroscopy. Crystal structure of ligand precursor, 2-(4-methyl-2-oxoquinolinyl-1-(2H)-yl)acetic acid (HL2), has been determined by X-ray dif...
Source: Journal of Inorganic Biochemistry - October 27, 2023 Category: Biochemistry Authors: Marijana P Kasalovi ć Sanja Jela ča Danijela Maksimovi ć-Ivanić Jelena La đarević Lidija Radovanovi ć Bojan Bo žić Sanja Mijatovi ć Neboj ša Đ Pantelić Goran N Kalu đerović Source Type: research
Kinetic and structural details of urease inactivation by thiuram disulphides
J Inorg Biochem. 2023 Oct 10;250:112398. doi: 10.1016/j.jinorgbio.2023.112398. Online ahead of print.ABSTRACTThis paper reports on the molecular details of the reactivity of urease, a nickel-dependent enzyme that catalyses the last step of organic nitrogen mineralization, with thiuram disulphides, a class of molecules known to inactivate the enzyme with high efficacy but for which the mechanism of action had not been yet established. IC50 values of tetramethylthiuram disulphide (TMTD or Thiram) and tetraethylthiuram disulphide (TETD or Disulfiram) in the low micromolar range were determined for plant and bacterial ureases....
Source: Journal of Inorganic Biochemistry - October 25, 2023 Category: Biochemistry Authors: Luca Mazzei Arundhati Paul Michele Cianci Marta Devodier Davide Mandelli Paolo Carloni Stefano Ciurli Source Type: research
Kinetic and structural details of urease inactivation by thiuram disulphides
J Inorg Biochem. 2023 Oct 10;250:112398. doi: 10.1016/j.jinorgbio.2023.112398. Online ahead of print.ABSTRACTThis paper reports on the molecular details of the reactivity of urease, a nickel-dependent enzyme that catalyses the last step of organic nitrogen mineralization, with thiuram disulphides, a class of molecules known to inactivate the enzyme with high efficacy but for which the mechanism of action had not been yet established. IC50 values of tetramethylthiuram disulphide (TMTD or Thiram) and tetraethylthiuram disulphide (TETD or Disulfiram) in the low micromolar range were determined for plant and bacterial ureases....
Source: Journal of Inorganic Biochemistry - October 25, 2023 Category: Biochemistry Authors: Luca Mazzei Arundhati Paul Michele Cianci Marta Devodier Davide Mandelli Paolo Carloni Stefano Ciurli Source Type: research
Kinetic and structural details of urease inactivation by thiuram disulphides
J Inorg Biochem. 2023 Oct 10;250:112398. doi: 10.1016/j.jinorgbio.2023.112398. Online ahead of print.ABSTRACTThis paper reports on the molecular details of the reactivity of urease, a nickel-dependent enzyme that catalyses the last step of organic nitrogen mineralization, with thiuram disulphides, a class of molecules known to inactivate the enzyme with high efficacy but for which the mechanism of action had not been yet established. IC50 values of tetramethylthiuram disulphide (TMTD or Thiram) and tetraethylthiuram disulphide (TETD or Disulfiram) in the low micromolar range were determined for plant and bacterial ureases....
Source: Journal of Inorganic Biochemistry - October 25, 2023 Category: Biochemistry Authors: Luca Mazzei Arundhati Paul Michele Cianci Marta Devodier Davide Mandelli Paolo Carloni Stefano Ciurli Source Type: research
Novel mono-, bi-, tri- and tetra-nuclear copper complexes that inhibit tumor growth through apoptosis and anti-angiogenesis
J Inorg Biochem. 2023 Oct 17;250:112403. doi: 10.1016/j.jinorgbio.2023.112403. Online ahead of print.ABSTRACTTo develop the next-generation metal agents for efficiently inhibiting tumor growth, a series of novel mononuclear, binuclear and trinuclear copper (Cu) thiophene-2-formaldehyde thiosemicarbazone complexes and a tetranuclear Cu 1,2,4-triazole-derived complex have been synthesized and their structure-activity relationships have been studied. The trinucleated Cu complex showed the strongest inhibitory activity against T24 cells among all the Cu complexes. Its antitumor effect in vivo was superior to that of cisplatin,...
Source: Journal of Inorganic Biochemistry - October 22, 2023 Category: Biochemistry Authors: Xiaojun Wang Minghui Zhu Shanhe Li Gang Xu Zhenlei Zhang Feng Yang Source Type: research
Novel mono-, bi-, tri- and tetra-nuclear copper complexes that inhibit tumor growth through apoptosis and anti-angiogenesis
J Inorg Biochem. 2023 Oct 17;250:112403. doi: 10.1016/j.jinorgbio.2023.112403. Online ahead of print.ABSTRACTTo develop the next-generation metal agents for efficiently inhibiting tumor growth, a series of novel mononuclear, binuclear and trinuclear copper (Cu) thiophene-2-formaldehyde thiosemicarbazone complexes and a tetranuclear Cu 1,2,4-triazole-derived complex have been synthesized and their structure-activity relationships have been studied. The trinucleated Cu complex showed the strongest inhibitory activity against T24 cells among all the Cu complexes. Its antitumor effect in vivo was superior to that of cisplatin,...
Source: Journal of Inorganic Biochemistry - October 22, 2023 Category: Biochemistry Authors: Xiaojun Wang Minghui Zhu Shanhe Li Gang Xu Zhenlei Zhang Feng Yang Source Type: research
Novel mono-, bi-, tri- and tetra-nuclear copper complexes that inhibit tumor growth through apoptosis and anti-angiogenesis
J Inorg Biochem. 2023 Oct 17;250:112403. doi: 10.1016/j.jinorgbio.2023.112403. Online ahead of print.ABSTRACTTo develop the next-generation metal agents for efficiently inhibiting tumor growth, a series of novel mononuclear, binuclear and trinuclear copper (Cu) thiophene-2-formaldehyde thiosemicarbazone complexes and a tetranuclear Cu 1,2,4-triazole-derived complex have been synthesized and their structure-activity relationships have been studied. The trinucleated Cu complex showed the strongest inhibitory activity against T24 cells among all the Cu complexes. Its antitumor effect in vivo was superior to that of cisplatin,...
Source: Journal of Inorganic Biochemistry - October 22, 2023 Category: Biochemistry Authors: Xiaojun Wang Minghui Zhu Shanhe Li Gang Xu Zhenlei Zhang Feng Yang Source Type: research
Immobilization of horseradish peroxidase on metal-organic framework to imporve enzyme activity for enhanced chemodynamic therapy
J Inorg Biochem. 2023 Oct 5;250:112394. doi: 10.1016/j.jinorgbio.2023.112394. Online ahead of print.ABSTRACTBio-enzymes have the advantages of strong substrate specificity, high catalytic efficiency, and minimal toxic side effects, making them promising drugs in cancer therapy. However, the poor stability and cellular penetrability of uncoated protein in the physiological environment severely restricts the direct application of Bio-enzyme. To address it, we report a metal-organic framework (MOF), Hf-DBA (H2DBA, biphenyl carboxylic acid ligands). The morphology of the Hf-DBA was revealed by TEM and the diameter was in the r...
Source: Journal of Inorganic Biochemistry - October 21, 2023 Category: Biochemistry Authors: Pengfei Shi Ziyong Wu Yingyan Liu Guoda Zhang Chuangli Zhang Source Type: research
Synthesis, characterization, and cytotoxic effects of new copper complexes using Schiff-base derivatives from natural sources
J Inorg Biochem. 2023 Oct 14;250:112401. doi: 10.1016/j.jinorgbio.2023.112401. Online ahead of print.ABSTRACTCopper(II) complexes are interesting for cancer treatment due to their unique properties, including their redox potential, possible coordination structures with different ligands, the most diverse geometries, and different biomolecule reactivity. The present work synthesized new copper(II) complexes with Schiff-base (imine) type ligands using natural aldehydes such as cinnamaldehyde, vanillin, or ethyl vanillin. The ligands were obtained through the reaction of these aldehydes with the amines 1,3-diaminopropane, 2,2...
Source: Journal of Inorganic Biochemistry - October 21, 2023 Category: Biochemistry Authors: Rafael N Gomes Matheus L Silva Kaio S Gomes Jo ão H G Lago Giselle Cerchiaro Source Type: research
Immobilization of horseradish peroxidase on metal-organic framework to imporve enzyme activity for enhanced chemodynamic therapy
J Inorg Biochem. 2023 Oct 5;250:112394. doi: 10.1016/j.jinorgbio.2023.112394. Online ahead of print.ABSTRACTBio-enzymes have the advantages of strong substrate specificity, high catalytic efficiency, and minimal toxic side effects, making them promising drugs in cancer therapy. However, the poor stability and cellular penetrability of uncoated protein in the physiological environment severely restricts the direct application of Bio-enzyme. To address it, we report a metal-organic framework (MOF), Hf-DBA (H2DBA, biphenyl carboxylic acid ligands). The morphology of the Hf-DBA was revealed by TEM and the diameter was in the r...
Source: Journal of Inorganic Biochemistry - October 21, 2023 Category: Biochemistry Authors: Pengfei Shi Ziyong Wu Yingyan Liu Guoda Zhang Chuangli Zhang Source Type: research
Synthesis, characterization, and cytotoxic effects of new copper complexes using Schiff-base derivatives from natural sources
J Inorg Biochem. 2023 Oct 14;250:112401. doi: 10.1016/j.jinorgbio.2023.112401. Online ahead of print.ABSTRACTCopper(II) complexes are interesting for cancer treatment due to their unique properties, including their redox potential, possible coordination structures with different ligands, the most diverse geometries, and different biomolecule reactivity. The present work synthesized new copper(II) complexes with Schiff-base (imine) type ligands using natural aldehydes such as cinnamaldehyde, vanillin, or ethyl vanillin. The ligands were obtained through the reaction of these aldehydes with the amines 1,3-diaminopropane, 2,2...
Source: Journal of Inorganic Biochemistry - October 21, 2023 Category: Biochemistry Authors: Rafael N Gomes Matheus L Silva Kaio S Gomes Jo ão H G Lago Giselle Cerchiaro Source Type: research
