Spectroscopy and absolute quantum efficiency of near-infrared electrochemiluminescence for a macrocyclic palladium complex
J Inorg Biochem. 2024 Feb 24;254:112514. doi: 10.1016/j.jinorgbio.2024.112514. Online ahead of print.ABSTRACTElectrochemiluminescence (ECL) is widely applied as a reliable tool in clinical diagnosis, including immunoassays, cancer biomarker detection, etc. Metal complexes with emission in the near-infrared (NIR) range possess distinct features such as high transmission and minimal tissue auto-absorption, making them versatile for applications in biosensing and other fields. Through ECL spectral studies of an O-linked nonaromatic benzitripyrrin (C^N^N^N) macrocyclic palladium complex (Pd1) with multiple pyrrole structures, ...
Source: Journal of Inorganic Biochemistry - February 29, 2024 Category: Biochemistry Authors: Congyang Zhang Ruizhong Zhang Ruijing Zhang Qiao Zhang Jun-Long Zhang Zhangjunlong Pku Edu Cn Zhifeng Ding Source Type: research

Spectroscopy and absolute quantum efficiency of near-infrared electrochemiluminescence for a macrocyclic palladium complex
J Inorg Biochem. 2024 Feb 24;254:112514. doi: 10.1016/j.jinorgbio.2024.112514. Online ahead of print.ABSTRACTElectrochemiluminescence (ECL) is widely applied as a reliable tool in clinical diagnosis, including immunoassays, cancer biomarker detection, etc. Metal complexes with emission in the near-infrared (NIR) range possess distinct features such as high transmission and minimal tissue auto-absorption, making them versatile for applications in biosensing and other fields. Through ECL spectral studies of an O-linked nonaromatic benzitripyrrin (C^N^N^N) macrocyclic palladium complex (Pd1) with multiple pyrrole structures, ...
Source: Journal of Inorganic Biochemistry - February 29, 2024 Category: Biochemistry Authors: Congyang Zhang Ruizhong Zhang Ruijing Zhang Qiao Zhang Jun-Long Zhang Zhangjunlong Pku Edu Cn Zhifeng Ding Source Type: research

Exploring the potential of the vitamin B < sub > 12 < /sub > derivative azidocobalamin to undergo Huisgen 1,3-dipolar azide-alkyne cycloaddition reactions
J Inorg Biochem. 2024 Feb 10;254:112504. doi: 10.1016/j.jinorgbio.2024.112504. Online ahead of print.ABSTRACTThere is considerable interest in using the metalloprotein cofactor vitamin B12 as a vehicle to deliver drugs and diagnostic agents into mammalian or bacterial cells by exploiting the B12-specific active uptake pathways. Conjugation of the cargo via the β-axial site or the 5'-OH of the ribose of the nucleotide are the most desirable sites, to maximise intracellular uptake. Herein we show the potential of conjugation at the beta-azido ligand of the vitamin B12 derivative azidocobalamin via a click-type azide-alkyne ...
Source: Journal of Inorganic Biochemistry - February 27, 2024 Category: Biochemistry Authors: Ben J Stackpole Jessica M Fredericksen Nicola E Brasch Source Type: research

Exploring the potential of the vitamin B < sub > 12 < /sub > derivative azidocobalamin to undergo Huisgen 1,3-dipolar azide-alkyne cycloaddition reactions
J Inorg Biochem. 2024 Feb 10;254:112504. doi: 10.1016/j.jinorgbio.2024.112504. Online ahead of print.ABSTRACTThere is considerable interest in using the metalloprotein cofactor vitamin B12 as a vehicle to deliver drugs and diagnostic agents into mammalian or bacterial cells by exploiting the B12-specific active uptake pathways. Conjugation of the cargo via the β-axial site or the 5'-OH of the ribose of the nucleotide are the most desirable sites, to maximise intracellular uptake. Herein we show the potential of conjugation at the beta-azido ligand of the vitamin B12 derivative azidocobalamin via a click-type azide-alkyne ...
Source: Journal of Inorganic Biochemistry - February 27, 2024 Category: Biochemistry Authors: Ben J Stackpole Jessica M Fredericksen Nicola E Brasch Source Type: research

Thermoresponsive carboplatin-releasing prodrugs
J Inorg Biochem. 2024 Feb 15;254:112505. doi: 10.1016/j.jinorgbio.2024.112505. Online ahead of print.ABSTRACTPlatinum-based anticancer drugs, while potent, are associated with numerous and severe side effects. Hyperthermia therapy is an effective adjuvant in anticancer treatment, however, clinically used platinum drugs have not been optimised for combination with hyperthermia. The derivatisation of existing anticancer drugs with appropriately chosen thermoresponsive moieties results in drugs being activated only at the heated site. Perfluorinated chains of varying lengths were installed on carboplatin, a clinically approve...
Source: Journal of Inorganic Biochemistry - February 20, 2024 Category: Biochemistry Authors: Aemilia D McAdam Lucinda K Batchelor Jan Romano-deGea Dmitry Vasilyev Paul J Dyson Source Type: research

Thermoresponsive carboplatin-releasing prodrugs
J Inorg Biochem. 2024 Feb 15;254:112505. doi: 10.1016/j.jinorgbio.2024.112505. Online ahead of print.ABSTRACTPlatinum-based anticancer drugs, while potent, are associated with numerous and severe side effects. Hyperthermia therapy is an effective adjuvant in anticancer treatment, however, clinically used platinum drugs have not been optimised for combination with hyperthermia. The derivatisation of existing anticancer drugs with appropriately chosen thermoresponsive moieties results in drugs being activated only at the heated site. Perfluorinated chains of varying lengths were installed on carboplatin, a clinically approve...
Source: Journal of Inorganic Biochemistry - February 20, 2024 Category: Biochemistry Authors: Aemilia D McAdam Lucinda K Batchelor Jan Romano-deGea Dmitry Vasilyev Paul J Dyson Source Type: research

Thermoresponsive carboplatin-releasing prodrugs
J Inorg Biochem. 2024 Feb 15;254:112505. doi: 10.1016/j.jinorgbio.2024.112505. Online ahead of print.ABSTRACTPlatinum-based anticancer drugs, while potent, are associated with numerous and severe side effects. Hyperthermia therapy is an effective adjuvant in anticancer treatment, however, clinically used platinum drugs have not been optimised for combination with hyperthermia. The derivatisation of existing anticancer drugs with appropriately chosen thermoresponsive moieties results in drugs being activated only at the heated site. Perfluorinated chains of varying lengths were installed on carboplatin, a clinically approve...
Source: Journal of Inorganic Biochemistry - February 20, 2024 Category: Biochemistry Authors: Aemilia D McAdam Lucinda K Batchelor Jan Romano-deGea Dmitry Vasilyev Paul J Dyson Source Type: research

Thermoresponsive carboplatin-releasing prodrugs
J Inorg Biochem. 2024 Feb 15;254:112505. doi: 10.1016/j.jinorgbio.2024.112505. Online ahead of print.ABSTRACTPlatinum-based anticancer drugs, while potent, are associated with numerous and severe side effects. Hyperthermia therapy is an effective adjuvant in anticancer treatment, however, clinically used platinum drugs have not been optimised for combination with hyperthermia. The derivatisation of existing anticancer drugs with appropriately chosen thermoresponsive moieties results in drugs being activated only at the heated site. Perfluorinated chains of varying lengths were installed on carboplatin, a clinically approve...
Source: Journal of Inorganic Biochemistry - February 20, 2024 Category: Biochemistry Authors: Aemilia D McAdam Lucinda K Batchelor Jan Romano-deGea Dmitry Vasilyev Paul J Dyson Source Type: research

Thermoresponsive carboplatin-releasing prodrugs
J Inorg Biochem. 2024 Feb 15;254:112505. doi: 10.1016/j.jinorgbio.2024.112505. Online ahead of print.ABSTRACTPlatinum-based anticancer drugs, while potent, are associated with numerous and severe side effects. Hyperthermia therapy is an effective adjuvant in anticancer treatment, however, clinically used platinum drugs have not been optimised for combination with hyperthermia. The derivatisation of existing anticancer drugs with appropriately chosen thermoresponsive moieties results in drugs being activated only at the heated site. Perfluorinated chains of varying lengths were installed on carboplatin, a clinically approve...
Source: Journal of Inorganic Biochemistry - February 20, 2024 Category: Biochemistry Authors: Aemilia D McAdam Lucinda K Batchelor Jan Romano-deGea Dmitry Vasilyev Paul J Dyson Source Type: research

Thermoresponsive carboplatin-releasing prodrugs
J Inorg Biochem. 2024 Feb 15;254:112505. doi: 10.1016/j.jinorgbio.2024.112505. Online ahead of print.ABSTRACTPlatinum-based anticancer drugs, while potent, are associated with numerous and severe side effects. Hyperthermia therapy is an effective adjuvant in anticancer treatment, however, clinically used platinum drugs have not been optimised for combination with hyperthermia. The derivatisation of existing anticancer drugs with appropriately chosen thermoresponsive moieties results in drugs being activated only at the heated site. Perfluorinated chains of varying lengths were installed on carboplatin, a clinically approve...
Source: Journal of Inorganic Biochemistry - February 20, 2024 Category: Biochemistry Authors: Aemilia D McAdam Lucinda K Batchelor Jan Romano-deGea Dmitry Vasilyev Paul J Dyson Source Type: research

The green cupredoxin CopI is a multicopper protein able to oxidize Cu(I)
J Inorg Biochem. 2024 Feb 8;254:112503. doi: 10.1016/j.jinorgbio.2024.112503. Online ahead of print.ABSTRACTAnthropogenic activities in agriculture and health use the antimicrobial properties of copper. This has led to copper accumulation in the environment and contributed to the emergence of copper resistant microorganisms. Understanding bacterial copper homeostasis diversity is therefore highly relevant since it could provide valuable targets for novel antimicrobial treatments. The periplasmic CopI protein is a monodomain cupredoxin comprising several copper binding sites and is directly involved in copper resistance in ...
Source: Journal of Inorganic Biochemistry - February 16, 2024 Category: Biochemistry Authors: Melanie Rossotti Diletta Arceri Pascal Mansuelle Olivier Bornet Anne Durand Soufian Ouchane H élène Launay Pierre Dorlet Source Type: research

The green cupredoxin CopI is a multicopper protein able to oxidize Cu(I)
J Inorg Biochem. 2024 Feb 8;254:112503. doi: 10.1016/j.jinorgbio.2024.112503. Online ahead of print.ABSTRACTAnthropogenic activities in agriculture and health use the antimicrobial properties of copper. This has led to copper accumulation in the environment and contributed to the emergence of copper resistant microorganisms. Understanding bacterial copper homeostasis diversity is therefore highly relevant since it could provide valuable targets for novel antimicrobial treatments. The periplasmic CopI protein is a monodomain cupredoxin comprising several copper binding sites and is directly involved in copper resistance in ...
Source: Journal of Inorganic Biochemistry - February 16, 2024 Category: Biochemistry Authors: Melanie Rossotti Diletta Arceri Pascal Mansuelle Olivier Bornet Anne Durand Soufian Ouchane H élène Launay Pierre Dorlet Source Type: research

The green cupredoxin CopI is a multicopper protein able to oxidize Cu(I)
J Inorg Biochem. 2024 Feb 8;254:112503. doi: 10.1016/j.jinorgbio.2024.112503. Online ahead of print.ABSTRACTAnthropogenic activities in agriculture and health use the antimicrobial properties of copper. This has led to copper accumulation in the environment and contributed to the emergence of copper resistant microorganisms. Understanding bacterial copper homeostasis diversity is therefore highly relevant since it could provide valuable targets for novel antimicrobial treatments. The periplasmic CopI protein is a monodomain cupredoxin comprising several copper binding sites and is directly involved in copper resistance in ...
Source: Journal of Inorganic Biochemistry - February 16, 2024 Category: Biochemistry Authors: Melanie Rossotti Diletta Arceri Pascal Mansuelle Olivier Bornet Anne Durand Soufian Ouchane H élène Launay Pierre Dorlet Source Type: research

The green cupredoxin CopI is a multicopper protein able to oxidize Cu(I)
J Inorg Biochem. 2024 Feb 8;254:112503. doi: 10.1016/j.jinorgbio.2024.112503. Online ahead of print.ABSTRACTAnthropogenic activities in agriculture and health use the antimicrobial properties of copper. This has led to copper accumulation in the environment and contributed to the emergence of copper resistant microorganisms. Understanding bacterial copper homeostasis diversity is therefore highly relevant since it could provide valuable targets for novel antimicrobial treatments. The periplasmic CopI protein is a monodomain cupredoxin comprising several copper binding sites and is directly involved in copper resistance in ...
Source: Journal of Inorganic Biochemistry - February 16, 2024 Category: Biochemistry Authors: Melanie Rossotti Diletta Arceri Pascal Mansuelle Olivier Bornet Anne Durand Soufian Ouchane H élène Launay Pierre Dorlet Source Type: research

Stabilization of a Cu-binding site by a highly conserved tryptophan residue
J Inorg Biochem. 2024 Feb 7;253:112501. doi: 10.1016/j.jinorgbio.2024.112501. Online ahead of print.ABSTRACTCopper serves as an essential cofactor for nearly all living organisms. There are still many gaps remaining in our knowledge of how Gram-positive bacteria import copper and maintain homeostasis. To obtain a better understanding of how these processes work, here we focus on the ycnKJI operon responsible for regulating copper levels in the Gram-positive bacterium Bacillus subtilis. This operon encodes three Cu-related proteins: a copper-dependent transcriptional repressor (YcnK), a putative copper importer (YcnJ), and ...
Source: Journal of Inorganic Biochemistry - February 11, 2024 Category: Biochemistry Authors: Yuri Rafael de Oliveira Silva Dia Zheng Stephen C Peters Oriana S Fisher Source Type: research