Metal-ruthenium complex based on dipyridylamine group as membrane-active antibacterial agent effectively decrease the development of drug-resistance on Staphylococcus aureus
J Inorg Biochem. 2023 Sep 22;249:112385. doi: 10.1016/j.jinorgbio.2023.112385. Online ahead of print.ABSTRACTStaphylococcus aureus (S. aureus), one of the Gram-positive bacteria, is easily to develop drug-resistance. Drug-resistant S. aureus infection leads to high morbidity and mortality. The complexes, namely [Ru(dpa)2(PSPIP)](PF6)2 (Ru1), [Ru(dpa)2(TSPIP)](PF6)2 (Ru2), and [Ru(dpa)2(TBPIP)](PF6)2 (Ru3), were synthesized using 2, 2'-dipyridylamine as an auxiliary ligand and three main ligands PSPIP, TSPIP, TBPIP. In vitro studies demonstrated that the Ru1-3 exhibited excellent antibacterial activity against S. aureus whi...
Source: Journal of Inorganic Biochemistry - September 29, 2023 Category: Biochemistry Authors: ChunYan Zhang LiQiang Wang Wei Deng HaiYan Huang JinTao Wang XiangWen Liao XueMin Duan RuJian Yu YanShi Xiong Source Type: research
Heme-copper and Heme O < sub > 2 < /sub > -derived synthetic (bioinorganic) chemistry toward an understanding of cytochrome c oxidase dioxygen chemistry
J Inorg Biochem. 2023 Sep 9;249:112367. doi: 10.1016/j.jinorgbio.2023.112367. Online ahead of print.ABSTRACTCytochrome c oxidase (CcO), also widely known as mitochondrial electron-transport-chain complex IV, is a multi-subunit transmembrane protein responsible for catalyzing the last step of the electron transport chain, dioxygen reduction to water, which is essential to the establishment and maintenance of the membrane proton gradient that drives ATP synthesis. Although many intermediates in the CcO catalytic cycle have been spectroscopically and/or computationally authenticated, the specifics regarding the IP intermediat...
Source: Journal of Inorganic Biochemistry - September 24, 2023 Category: Biochemistry Authors: Sanjib Panda Hai Phan Kenneth D Karlin Source Type: research
Heme-copper and Heme O < sub > 2 < /sub > -derived synthetic (bioinorganic) chemistry toward an understanding of cytochrome c oxidase dioxygen chemistry
J Inorg Biochem. 2023 Sep 9;249:112367. doi: 10.1016/j.jinorgbio.2023.112367. Online ahead of print.ABSTRACTCytochrome c oxidase (CcO), also widely known as mitochondrial electron-transport-chain complex IV, is a multi-subunit transmembrane protein responsible for catalyzing the last step of the electron transport chain, dioxygen reduction to water, which is essential to the establishment and maintenance of the membrane proton gradient that drives ATP synthesis. Although many intermediates in the CcO catalytic cycle have been spectroscopically and/or computationally authenticated, the specifics regarding the IP intermediat...
Source: Journal of Inorganic Biochemistry - September 24, 2023 Category: Biochemistry Authors: Sanjib Panda Hai Phan Kenneth D Karlin Source Type: research
Heme-copper and Heme O < sub > 2 < /sub > -derived synthetic (bioinorganic) chemistry toward an understanding of cytochrome c oxidase dioxygen chemistry
J Inorg Biochem. 2023 Sep 9;249:112367. doi: 10.1016/j.jinorgbio.2023.112367. Online ahead of print.ABSTRACTCytochrome c oxidase (CcO), also widely known as mitochondrial electron-transport-chain complex IV, is a multi-subunit transmembrane protein responsible for catalyzing the last step of the electron transport chain, dioxygen reduction to water, which is essential to the establishment and maintenance of the membrane proton gradient that drives ATP synthesis. Although many intermediates in the CcO catalytic cycle have been spectroscopically and/or computationally authenticated, the specifics regarding the IP intermediat...
Source: Journal of Inorganic Biochemistry - September 24, 2023 Category: Biochemistry Authors: Sanjib Panda Hai Phan Kenneth D Karlin Source Type: research
Heme-copper and Heme O < sub > 2 < /sub > -derived synthetic (bioinorganic) chemistry toward an understanding of cytochrome c oxidase dioxygen chemistry
J Inorg Biochem. 2023 Sep 9;249:112367. doi: 10.1016/j.jinorgbio.2023.112367. Online ahead of print.ABSTRACTCytochrome c oxidase (CcO), also widely known as mitochondrial electron-transport-chain complex IV, is a multi-subunit transmembrane protein responsible for catalyzing the last step of the electron transport chain, dioxygen reduction to water, which is essential to the establishment and maintenance of the membrane proton gradient that drives ATP synthesis. Although many intermediates in the CcO catalytic cycle have been spectroscopically and/or computationally authenticated, the specifics regarding the IP intermediat...
Source: Journal of Inorganic Biochemistry - September 24, 2023 Category: Biochemistry Authors: Sanjib Panda Hai Phan Kenneth D Karlin Source Type: research
